{
 "generated": "2026-09-12",
 "version": "1",
 "site": "https://usebiotransfer.org",
 "licence": "Figures are reproduced from the sources named in each row (SEER, CBTRUS, NIH RePORTER, openFDA, Open Targets, ClinicalTrials.gov, NCBI GEO, Europe PMC, iCite); review each source's terms before redistribution. The joins and derived figures are CC BY 4.0, cite usebiotransfer.org.",
 "diseases": [
  {
   "slug": "acute-myeloid-leukemia",
   "label": "Acute myeloid leukemia",
   "page": "https://usebiotransfer.org/disease/acute-myeloid-leukemia/",
   "facts": "https://usebiotransfer.org/disease/acute-myeloid-leukemia.json"
  },
  {
   "slug": "anal-cancer",
   "label": "Anal cancer",
   "page": "https://usebiotransfer.org/disease/anal-cancer/",
   "facts": "https://usebiotransfer.org/disease/anal-cancer.json"
  },
  {
   "slug": "bladder-cancer",
   "label": "Bladder cancer",
   "page": "https://usebiotransfer.org/disease/bladder-cancer/",
   "facts": "https://usebiotransfer.org/disease/bladder-cancer.json"
  },
  {
   "slug": "breast-cancer",
   "label": "Breast cancer",
   "page": "https://usebiotransfer.org/disease/breast-cancer/",
   "facts": "https://usebiotransfer.org/disease/breast-cancer.json"
  },
  {
   "slug": "cervical-cancer",
   "label": "Cervical cancer",
   "page": "https://usebiotransfer.org/disease/cervical-cancer/",
   "facts": "https://usebiotransfer.org/disease/cervical-cancer.json"
  },
  {
   "slug": "chronic-lymphocytic-leukemia",
   "label": "Chronic lymphocytic leukemia",
   "page": "https://usebiotransfer.org/disease/chronic-lymphocytic-leukemia/",
   "facts": "https://usebiotransfer.org/disease/chronic-lymphocytic-leukemia.json"
  },
  {
   "slug": "chronic-myeloid-leukemia",
   "label": "Chronic myeloid leukemia",
   "page": "https://usebiotransfer.org/disease/chronic-myeloid-leukemia/",
   "facts": "https://usebiotransfer.org/disease/chronic-myeloid-leukemia.json"
  },
  {
   "slug": "colorectal-cancer",
   "label": "Colorectal cancer",
   "page": "https://usebiotransfer.org/disease/colorectal-cancer/",
   "facts": "https://usebiotransfer.org/disease/colorectal-cancer.json"
  },
  {
   "slug": "diffuse-large-b-cell-lymphoma",
   "label": "Diffuse large B-cell lymphoma",
   "page": "https://usebiotransfer.org/disease/diffuse-large-b-cell-lymphoma/",
   "facts": "https://usebiotransfer.org/disease/diffuse-large-b-cell-lymphoma.json"
  },
  {
   "slug": "endometrial-cancer",
   "label": "Endometrial cancer",
   "page": "https://usebiotransfer.org/disease/endometrial-cancer/",
   "facts": "https://usebiotransfer.org/disease/endometrial-cancer.json"
  },
  {
   "slug": "esophageal-cancer",
   "label": "Esophageal cancer",
   "page": "https://usebiotransfer.org/disease/esophageal-cancer/",
   "facts": "https://usebiotransfer.org/disease/esophageal-cancer.json"
  },
  {
   "slug": "ewing-sarcoma",
   "label": "Ewing sarcoma",
   "page": "https://usebiotransfer.org/disease/ewing-sarcoma/",
   "facts": "https://usebiotransfer.org/disease/ewing-sarcoma.json"
  },
  {
   "slug": "follicular-lymphoma",
   "label": "Follicular lymphoma",
   "page": "https://usebiotransfer.org/disease/follicular-lymphoma/",
   "facts": "https://usebiotransfer.org/disease/follicular-lymphoma.json"
  },
  {
   "slug": "gastric-cancer",
   "label": "Gastric cancer",
   "page": "https://usebiotransfer.org/disease/gastric-cancer/",
   "facts": "https://usebiotransfer.org/disease/gastric-cancer.json"
  },
  {
   "slug": "glioblastoma",
   "label": "Glioblastoma",
   "page": "https://usebiotransfer.org/disease/glioblastoma/",
   "facts": "https://usebiotransfer.org/disease/glioblastoma.json"
  },
  {
   "slug": "head-and-neck-cancer",
   "label": "Head and neck cancer",
   "page": "https://usebiotransfer.org/disease/head-and-neck-cancer/",
   "facts": "https://usebiotransfer.org/disease/head-and-neck-cancer.json"
  },
  {
   "slug": "hepatocellular-carcinoma",
   "label": "Hepatocellular carcinoma",
   "page": "https://usebiotransfer.org/disease/hepatocellular-carcinoma/",
   "facts": "https://usebiotransfer.org/disease/hepatocellular-carcinoma.json"
  },
  {
   "slug": "hodgkin-lymphoma",
   "label": "Hodgkin lymphoma",
   "page": "https://usebiotransfer.org/disease/hodgkin-lymphoma/",
   "facts": "https://usebiotransfer.org/disease/hodgkin-lymphoma.json"
  },
  {
   "slug": "kidney-cancer",
   "label": "Kidney cancer",
   "page": "https://usebiotransfer.org/disease/kidney-cancer/",
   "facts": "https://usebiotransfer.org/disease/kidney-cancer.json"
  },
  {
   "slug": "lung-cancer",
   "label": "Lung cancer",
   "page": "https://usebiotransfer.org/disease/lung-cancer/",
   "facts": "https://usebiotransfer.org/disease/lung-cancer.json"
  },
  {
   "slug": "medulloblastoma",
   "label": "Medulloblastoma",
   "page": "https://usebiotransfer.org/disease/medulloblastoma/",
   "facts": "https://usebiotransfer.org/disease/medulloblastoma.json"
  },
  {
   "slug": "melanoma",
   "label": "Melanoma",
   "page": "https://usebiotransfer.org/disease/melanoma/",
   "facts": "https://usebiotransfer.org/disease/melanoma.json"
  },
  {
   "slug": "multiple-myeloma",
   "label": "Multiple myeloma",
   "page": "https://usebiotransfer.org/disease/multiple-myeloma/",
   "facts": "https://usebiotransfer.org/disease/multiple-myeloma.json"
  },
  {
   "slug": "neuroblastoma",
   "label": "Neuroblastoma",
   "page": "https://usebiotransfer.org/disease/neuroblastoma/",
   "facts": "https://usebiotransfer.org/disease/neuroblastoma.json"
  },
  {
   "slug": "ovarian-cancer",
   "label": "Ovarian cancer",
   "page": "https://usebiotransfer.org/disease/ovarian-cancer/",
   "facts": "https://usebiotransfer.org/disease/ovarian-cancer.json"
  },
  {
   "slug": "pancreatic-cancer",
   "label": "Pancreatic cancer",
   "page": "https://usebiotransfer.org/disease/pancreatic-cancer/",
   "facts": "https://usebiotransfer.org/disease/pancreatic-cancer.json"
  },
  {
   "slug": "prostate-cancer",
   "label": "Prostate cancer",
   "page": "https://usebiotransfer.org/disease/prostate-cancer/",
   "facts": "https://usebiotransfer.org/disease/prostate-cancer.json"
  },
  {
   "slug": "soft-tissue-sarcoma",
   "label": "Soft tissue sarcoma",
   "page": "https://usebiotransfer.org/disease/soft-tissue-sarcoma/",
   "facts": "https://usebiotransfer.org/disease/soft-tissue-sarcoma.json"
  },
  {
   "slug": "testicular-cancer",
   "label": "Testicular cancer",
   "page": "https://usebiotransfer.org/disease/testicular-cancer/",
   "facts": "https://usebiotransfer.org/disease/testicular-cancer.json"
  },
  {
   "slug": "thyroid-cancer",
   "label": "Thyroid cancer",
   "page": "https://usebiotransfer.org/disease/thyroid-cancer/",
   "facts": "https://usebiotransfer.org/disease/thyroid-cancer.json"
  }
 ],
 "endpoints": {
  "disease_facts": {
   "url": "https://usebiotransfer.org/disease/<slug>.json",
   "what": "Every number on one briefing with its source, query and retrieval date; the facts_hash changes when any of them does.",
   "keys": [
    "built",
    "disease",
    "facts_hash",
    "label",
    "query",
    "retrieved",
    "sources",
    "targets",
    "trials",
    "url"
   ]
  },
  "burden": {
   "url": "https://usebiotransfer.org/disease/burden.json",
   "what": "One row per disease: cases, deaths, survival, median age, years of life lost, NIH funding and funding per life-year, each with its mapping quality (direct, proxy, derived_proxy) or unavailable.",
   "row_fields": [
    "any_proxy",
    "burden_retrieved",
    "burden_source",
    "cases",
    "cases_mapping",
    "cases_year",
    "deaths",
    "deaths_mapping",
    "funding_awards",
    "funding_total",
    "funding_year",
    "label",
    "median_age",
    "n_labelled_drugs",
    "n_ranked_series",
    "n_targets",
    "n_targets_approved_here",
    "nci_share",
    "per_case",
    "per_life_year",
    "slug",
    "survival",
    "survival_mapping",
    "yll_per_case",
    "yll_total"
   ]
  },
  "genes": {
   "url": "https://usebiotransfer.org/disease/index/genes.json",
   "what": "Genes on the target list of 2 or more briefings; per disease, drug count, approval status, top trial stage, antigen mapping, cell-therapy trials.",
   "row_fields": [
    "antigen",
    "approved_any",
    "approved_here",
    "approved_here_n",
    "cell_therapy_active",
    "cell_therapy_trials",
    "disease",
    "label",
    "n_drugs",
    "top_stage",
    "tractability_sm"
   ]
  },
  "drugs": {
   "url": "https://usebiotransfer.org/disease/index/drugs.json",
   "what": "Drugs with an FDA label naming, or a registered trial in, 2 or more briefed diseases; per disease, label role and trial counts.",
   "row_fields": [
    "brands",
    "disease",
    "label",
    "label_role",
    "names",
    "ot_genes",
    "ot_stage",
    "trials",
    "trials_active"
   ]
  },
  "antigens": {
   "url": "https://usebiotransfer.org/disease/index/antigens.json",
   "what": "Cell-therapy antigens named in trials of 2 or more diseases.",
   "row_fields": [
    "active",
    "cell_therapy",
    "cell_therapy_active",
    "cell_therapy_withdrawn",
    "disease",
    "label",
    "name",
    "trials"
   ]
  },
  "pages": {
   "url": "https://usebiotransfer.org/disease/index/pages.json",
   "what": "Every cross-disease page the site serves, for crawling."
  },
  "accessions": {
   "url": "https://usebiotransfer.org/disease/<slug>.accessions.json",
   "what": "The ranked GEO series of one briefing with score, reuse count, RCR, cohort and clinical annotation."
  }
 },
 "method": {
  "yll": "(1 - five_year_relative_survival) * (78.4 - median_age_at_diagnosis) * annual_incident_cases; not computed where any input is unavailable",
  "per_life_year": "NIH obligations in the latest fiscal year / annual years of life lost; not computed where cases are a lower bound",
  "literature_filters": "Each disease profile declares MeSH exclusions, soft and hard free-text exclusions and a mention floor; the profile and every dropped record are published with the briefing.",
  "profiles": "https://usebiotransfer.org/disease/ (the 'How this page is built' section of each briefing)"
 }
}