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Efficacy and Safety of GDC-0449 in Patients With Basal Cell Nevus Syndrome (BCNS)", "status": "COMPLETED", "last_update": "2021-01-11", "phase": "PHASE2", "study_type": "INTERVENTIONAL" }, { "nct": "NCT00959647", "title": "A Study of Vismodegib (GDC-0449) in Patients Treated With Vismodegib in a Previous Genentech-sponsored Phase I or II Cancer Study", "status": "COMPLETED", "last_update": "2026-05-08", "phase": "PHASE2", "study_type": "INTERVENTIONAL" }, { "nct": "NCT00968981", "title": "A Study of Hedgehog Pathway Inhibitor GDC-0449 in Patients With Locally Advanced or Metastatic Solid Tumors That Are Refractory to Standard Therapy or for Whom No Standard Therapy Exists", "status": "COMPLETED", "last_update": "2017-07-11", "phase": "PHASE1", "study_type": "INTERVENTIONAL" }, { "nct": "NCT01106508", "title": "A Dose Finding and Safety Study of Oral LEQ506 in Patients With Advanced Solid Tumors", "status": "COMPLETED", "last_update": "2020-12-17", "phase": "PHASE1", "study_type": "INTERVENTIONAL" }, { "nct": "NCT01204073", "title": "A Study of TAK-441 in Adult Patients With Advanced Nonhematologic Malignancies", "status": "COMPLETED", "last_update": "2013-07-02", "phase": "PHASE1", "study_type": "INTERVENTIONAL" }, { "nct": "NCT01208831", "title": "An East Asian Study of LDE225", "status": "COMPLETED", "last_update": "2020-12-19", "phase": "PHASE1", "study_type": "INTERVENTIONAL" }, { "nct": "NCT01350115", "title": "Efficacy, Safety and Pharmacokinetics of Oral LDE225 in Treatment of Patients With Nevoid Basal Cell Carcinoma Syndrome (NBCCS)", "status": "COMPLETED", "last_update": "2015-10-19", "phase": "PHASE2", "study_type": "INTERVENTIONAL" }, { "nct": "NCT01529450", "title": "Pilot LDE225 in Locally Advanced or Metastatic BCC + Previously Tx Non-LDE225 Smoothened Inhibitors", "status": "COMPLETED", "last_update": "2017-01-16", "phase": "NA", "study_type": "INTERVENTIONAL" }, { "nct": "NCT01631331", "title": "Vismodegib in Treating Patients With Basal Cell Carcinoma (BCC)", "status": "COMPLETED", "last_update": "2017-12-08", "phase": "EARLY_PHASE1", "study_type": "INTERVENTIONAL" }, { "nct": "NCT01791894", "title": "Arsenic Trioxide in Treating Patients With Basal Cell Carcinoma", "status": "COMPLETED", "last_update": "2018-06-08", "phase": "PHASE1/PHASE2", "study_type": "INTERVENTIONAL" }, { "nct": "NCT02690948", "title": "Pembrolizumab With or Without Vismodegib in Treating Metastatic or Unresectable Basal Cell Skin Cancer", "status": "COMPLETED", "last_update": "2019-03-08", "phase": "PHASE1/PHASE2", "study_type": "INTERVENTIONAL" }, { "nct": "NCT02699723", "title": "Arsenic Trioxide and Itraconazole in Treating Patients With Advanced Basal Cell Cancer", "status": "WITHDRAWN", "last_update": "2020-10-22", "phase": "EARLY_PHASE1", "study_type": "INTERVENTIONAL" }, { "nct": "NCT02735356", "title": "Topical Itraconazole in Treating Patients With Basal Cell Cancer", "status": "COMPLETED", "last_update": "2019-04-11", "phase": "EARLY_PHASE1", "study_type": "INTERVENTIONAL" }, { "nct": "NCT02762084", "title": "Trial of Patidegib Gel 2%, 4%, and Vehicle to Decrease the Number of Surgically Eligible Basal Cell Carcinomas in Gorlin Syndrome Patients", "status": "COMPLETED", "last_update": "2020-07-23", "phase": "PHASE2", "study_type": "INTERVENTIONAL" }, { "nct": "NCT02828111", "title": "Clinical Trial of Patidegib Gel 2%, 4%, and Vehicle Applied Once or Twice Daily to Decrease the GLI1 Biomarker in Sporadic Nodular Basal Cell Carcinomas", "status": "COMPLETED", "last_update": "2019-01-08", "phase": "PHASE2", "study_type": "INTERVENTIONAL" }, { "nct": "NCT03070691", "title": "Efficacy, Safety and Tolerability of Topically Applied LDE225 Cream (Hedgehog Pathway Inhibitor) in Adult Patients With Nevoid Basal Cell Carcinoma Syndrome (NBCCS)", "status": "WITHDRAWN", "last_update": "2017-05-05", "phase": "PHASE2/PHASE3", "study_type": "INTERVENTIONAL" }, { "nct": "NCT03132636", "title": "PD-1 in Patients With Advanced Basal Cell Carcinoma Who Experienced Progression of Disease on Hedgehog Pathway Inhibitor Therapy, or Were Intolerant of Prior Hedgehog Pathway Inhibitor Therapy", "status": "COMPLETED", "last_update": "2025-04-08", "phase": "PHASE2", "study_type": "INTERVENTIONAL" }, { "nct": "NCT03703310", "title": "Study of Patidegib Topical Gel, 2%, for the Reduction of Disease Burden of Persistently Developing Basal Cell Carcinomas (BCCs) in Subjects With Basal Cell Nevus Syndrome (Gorlin Syndrome)", "status": "COMPLETED", "last_update": "2024-07-03", "phase": "PHASE3", "study_type": "INTERVENTIONAL" }, { "nct": "NCT03734913", "title": "A Phase 1 Study of ZSP1602 in Participants With Advanced Solid Tumors", "status": "UNKNOWN", "last_update": "2020-07-22", "phase": "PHASE1", "study_type": "INTERVENTIONAL" }, { "nct": "NCT04155190", "title": "A Study of Patidegib Topical Gel, 2%, for the Reduction of Disease Burden of Persistently Developing Basal Cell Carcinomas in Patients With Non-Gorlin High Frequency BCC", "status": "TERMINATED", "last_update": "2026-07-21", "phase": "PHASE2", "study_type": "INTERVENTIONAL" }, { "nct": "NCT04308395", "title": "Extension Study of Patidegib Topical Gel, 2% in Subjects With Gorlin Syndrome (Basal Cell Nevus Syndrome)", "status": "TERMINATED", "last_update": "2024-09-24", "phase": "PHASE3", "study_type": "INTERVENTIONAL" }, { "nct": "NCT04416516", "title": "Safety and Efficacy of ASN-002 Combined With a Hedgehog Pathway Inhibitor", "status": "COMPLETED", "last_update": "2024-04-10", "phase": "PHASE2", "study_type": "INTERVENTIONAL" }, { "nct": "NCT04679480", "title": "Anti-PD1-antibody and Pulsed HHI for Advanced BCC", "status": "UNKNOWN", "last_update": "2024-07-30", "phase": "PHASE2", "study_type": "INTERVENTIONAL" }, { "nct": "NCT04916002", "title": "A Trial To Find Out If Vidutolimod Together With Cemiplimab Is Safe And If It Works In Adult Participants With Advanced Cancer Or Metastatic Cancer", "status": "TERMINATED", "last_update": "2026-06-09", "phase": "PHASE2", "study_type": "INTERVENTIONAL" }, { "nct": "NCT06357988", "title": "Testing GDC-0449 (Vismodegib) as Potentially Targeted Treatment in Cancers With Smoothened or Patched 1 Mutant Tumors (MATCH - Subprotocol T)", "status": "ACTIVE_NOT_RECRUITING", "last_update": "2026-05-28", "phase": "PHASE2", "study_type": "INTERVENTIONAL" } ], "cell_therapy": { "n": 0, "n_observational": 0, "n_active": 0, "n_withdrawn": 0, "trials": [] }, "synonyms_searched": [ "Hedgehog", "GLI", "arsenic trioxide" ] }, "CTLA-4": { "n": 5, "n_observational": 0, "n_active": 4, "n_withdrawn": 1, "trials": [ { "nct": "NCT03521830", "title": "Nivolumab Alone or Plus Relatlimab or Ipilimumab for Patients With Locally-Advanced Unresectable or Metastatic Basal Cell Carcinoma", "status": "RECRUITING", "last_update": "2026-04-29", "phase": "PHASE2", "study_type": "INTERVENTIONAL" }, { "nct": "NCT05896839", "title": "Immunotherapy in Combination With Prednisone and Sirolimus for Kidney Transplant Recipients With Unresectable or Metastatic Skin Cancer", "status": "RECRUITING", "last_update": "2026-08-31", "phase": "PHASE1/PHASE2", "study_type": "INTERVENTIONAL" }, { "nct": "NCT02834013", "title": "Nivolumab and Ipilimumab in Treating Patients With Rare Tumors", "status": "ACTIVE_NOT_RECRUITING", "last_update": "2026-06-17", "phase": "PHASE2", "study_type": "INTERVENTIONAL" }, { "nct": "NCT03767439", "title": "Nivolumab With Vismodegib in Patients With Basal Cell Nevus Syndrome", "status": "WITHDRAWN", "last_update": "2019-12-18", "phase": "PHASE2", "study_type": "INTERVENTIONAL" }, { "nct": "NCT03816332", "title": "Tacrolimus, Nivolumab, and Ipilimumab in Treating Kidney Transplant Recipients With Selected Unresectable or Metastatic Cancers", "status": "ACTIVE_NOT_RECRUITING", "last_update": "2026-07-31", "phase": "PHASE1", "study_type": "INTERVENTIONAL" } ], "cell_therapy": { "n": 0, "n_observational": 0, "n_active": 0, "n_withdrawn": 0, "trials": [] }, "synonyms_searched": [ "CTLA-4", "ipilimumab" ] }, "oncolytic": { "n": 3, "n_observational": 0, "n_active": 2, "n_withdrawn": 0, "trials": [ { "nct": "NCT02978625", "title": "Talimogene Laherparepvec and Nivolumab in Treating Patients With Refractory Lymphomas or Advanced or Refractory Non-melanoma Skin Cancers", "status": "ACTIVE_NOT_RECRUITING", "last_update": "2026-08-13", "phase": "PHASE2", "study_type": "INTERVENTIONAL" }, { "nct": "NCT03458117", "title": "T-VEC in Non-melanoma Skin Cancer", "status": "COMPLETED", "last_update": "2022-03-18", "phase": "PHASE1", "study_type": "INTERVENTIONAL" }, { "nct": "NCT04349436", "title": "Study to Investigate the Efficacy and Safety of RP1 in Adult Patients With Organ Transplants and Advanced Skin Malignancies", "status": "ACTIVE_NOT_RECRUITING", "last_update": "2026-04-22", "phase": "PHASE1/PHASE2", "study_type": "INTERVENTIONAL" } ], "cell_therapy": { "n": 0, "n_observational": 0, "n_active": 0, "n_withdrawn": 0, "trials": [] }, "synonyms_searched": [ "RP1", "vusolimogene", "talimogene", "T-VEC" ] }, "imiquimod": { "n": 54, "n_observational": 6, "n_active": 7, "n_withdrawn": 0, "trials": [ { "nct": "NCT06623201", "title": "Blue-Light Photodynamic Therapy and Sonidegib for Multiple Basal Cell Carcinomas", "status": "RECRUITING", "last_update": "2026-01-29", "phase": "PHASE1", "study_type": "INTERVENTIONAL" }, { "nct": "NCT07241585", "title": "Vitamin D Effects on Immune Microenvironment of Nonmelanoma Skin Cancer After Photodynamic Therapy (PDT)", "status": "RECRUITING", "last_update": "2026-08-18", "phase": "NA", "study_type": "INTERVENTIONAL" }, { "nct": "NCT07251413", "title": "Cemiplimab Plus Imiquimod and Laser Therapy As Neoadjuvant Treatment In Cutaneous Basal Cell Carcinoma", "status": "RECRUITING", "last_update": "2025-12-01", "phase": "PHASE1/PHASE2", "study_type": "INTERVENTIONAL" }, { "nct": "NCT07381972", "title": "Photodynamic Therapy Associated With Sonodynamic Therapy for the Treatment of 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"NCT00049959", "title": "Two Studies to Determine if Verteporfin PDT is Effective & Safe in Treating Multiple Basal Cell Carcinoma of the Skin.", "status": "TERMINATED", "last_update": "2011-03-16", "phase": "PHASE3", "study_type": "INTERVENTIONAL" }, { "nct": "NCT00066872", "title": "Topical Imiquimod Compared With Surgery in Treating Patients With Basal Cell Skin Cancer", "status": "COMPLETED", "last_update": "2013-09-17", "phase": "PHASE3", "study_type": "INTERVENTIONAL" }, { "nct": "NCT00079300", "title": "Imiquimod Cream in Treating Patients With Basal Cell Skin Cancer", "status": "COMPLETED", "last_update": "2013-04-26", "phase": "PHASE1", "study_type": "INTERVENTIONAL" }, { "nct": "NCT00103246", "title": "Photodynamic Therapy Using Silicon Phthalocyanine 4 in Treating Patients With Actinic Keratosis, Bowen's Disease, Skin Cancer, or Stage I or Stage II Mycosis Fungoides", "status": "COMPLETED", "last_update": "2019-01-22", "phase": "PHASE1", "study_type": "INTERVENTIONAL" }, { 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With Nevoid Basal Cell Carcinoma Syndrome (NBCCS)", "status": "COMPLETED", "last_update": "2015-10-19", "phase": "PHASE2", "study_type": "INTERVENTIONAL" }, { "nct": "NCT01529450", "title": "Pilot LDE225 in Locally Advanced or Metastatic BCC + Previously Tx Non-LDE225 Smoothened Inhibitors", "status": "COMPLETED", "last_update": "2017-01-16", "phase": "NA", "study_type": "INTERVENTIONAL" }, { "nct": "NCT02002689", "title": "LDE225 for Patients With PTCH1 or SMO Mutated Tumors", "status": "TERMINATED", "last_update": "2016-05-02", "phase": "PHASE2", "study_type": "INTERVENTIONAL" }, { "nct": "NCT02303041", "title": "Pilot Study of Sonidegib and Buparlisib in Treating Patients With Advanced or Metastatic Basal Cell Carcinoma", "status": "TERMINATED", "last_update": "2019-01-29", "phase": "PHASE2", "study_type": "INTERVENTIONAL" }, { "nct": "NCT03070691", "title": "Efficacy, Safety and Tolerability of Topically Applied LDE225 Cream (Hedgehog Pathway Inhibitor) in Adult Patients With Nevoid Basal Cell Carcinoma Syndrome (NBCCS)", "status": "WITHDRAWN", "last_update": "2017-05-05", "phase": "PHASE2/PHASE3", "study_type": "INTERVENTIONAL" }, { "nct": "NCT03534947", "title": "A Study to Evaluate Neoadjuvant Sonidegib Followed by Surgery or Imiquimod in the Management of Basal Cell Carcinoma", "status": "COMPLETED", "last_update": "2025-12-16", "phase": "PHASE2", "study_type": "INTERVENTIONAL" }, { "nct": "NCT04679480", "title": "Anti-PD1-antibody and Pulsed HHI for Advanced BCC", "status": "UNKNOWN", "last_update": "2024-07-30", "phase": "PHASE2", "study_type": "INTERVENTIONAL" }, { "nct": "NCT04806646", "title": "Tailored Sonidegib Schedule After Complete Response in BCC", "status": "ACTIVE_NOT_RECRUITING", "last_update": "2026-06-01", "phase": "PHASE2", "study_type": "INTERVENTIONAL" }, { "nct": "NCT06880848", "title": "Sonidegib in Adult Patients With Locally Advanced Basal Cell Carcinoma (laBCC) in China", "status": "COMPLETED", "last_update": "2025-09-24", "phase": "PHASE4", "study_type": "INTERVENTIONAL" } ] }, "SPARTALIZUMAB": { "n": 1, "n_observational": 0, "n_active": 0, "n_withdrawn": 0, "trials": [ { "nct": "NCT02900664", "title": "A Study of PDR001 in Combination With CJM112, EGF816, Ilaris\u00ae (Canakinumab) or Mekinist\u00ae (Trametinib)", "status": "COMPLETED", "last_update": "2022-03-29", "phase": "PHASE1", "study_type": "INTERVENTIONAL" } ] }, "TAK-441": { "n": 1, "n_observational": 0, "n_active": 0, "n_withdrawn": 0, "trials": [ { "nct": "NCT01204073", "title": "A Study of TAK-441 in Adult Patients With Advanced Nonhematologic Malignancies", "status": "COMPLETED", "last_update": "2013-07-02", "phase": "PHASE1", "study_type": "INTERVENTIONAL" } ] }, "VISMODEGIB": { "n": 29, "n_observational": 6, "n_active": 4, "n_withdrawn": 1, "trials": [ { "nct": "NCT05561634", "title": "Radiotherapy by Sonic Hedgehog Pathway Inhibitors in Basal Cell Carcinoma", "status": "RECRUITING", "last_update": "2025-09-30", "phase": "PHASE2", 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"study_type": "INTERVENTIONAL" }, { "nct": "NCT00959647", "title": "A Study of Vismodegib (GDC-0449) in Patients Treated With Vismodegib in a Previous Genentech-sponsored Phase I or II Cancer Study", "status": "COMPLETED", "last_update": "2026-05-08", "phase": "PHASE2", "study_type": "INTERVENTIONAL" }, { "nct": "NCT00968981", "title": "A Study of Hedgehog Pathway Inhibitor GDC-0449 in Patients With Locally Advanced or Metastatic Solid Tumors That Are Refractory to Standard Therapy or for Whom No Standard Therapy Exists", "status": "COMPLETED", "last_update": "2017-07-11", "phase": "PHASE1", "study_type": "INTERVENTIONAL" }, { "nct": "NCT01108094", "title": "Pilot Biomarker Trial to Evaluate the Efficacy of Itraconazole in Patients w/ Basal Cell Carcinomas", "status": "COMPLETED", "last_update": "2018-11-13", "phase": "PHASE2", "study_type": "INTERVENTIONAL" }, { "nct": "NCT01201915", "title": "A Study Evaluating the Efficacy and Safety of Vismodegib (GDC-0449) in Operable Basal Cell Carcinoma", "status": "COMPLETED", "last_update": "2014-06-24", "phase": "PHASE2", "study_type": "INTERVENTIONAL" }, { "nct": "NCT01367665", "title": "STEVIE: A Study of Vismodegib in Patients With Locally Advanced or Metastatic Basal Cell Carcinoma", "status": "COMPLETED", "last_update": "2019-06-06", "phase": "PHASE2", "study_type": "INTERVENTIONAL" }, { "nct": "NCT01543581", "title": "Vismodegib for Treatment of Basal Cell Carcinoma", "status": "COMPLETED", "last_update": "2014-09-26", "phase": "PHASE2", "study_type": "INTERVENTIONAL" }, { "nct": "NCT01556009", "title": "Trial Comparing the Effects of Intermittent Vismodegib vs. PDT in Patients With Multiple Basal Cell Carcinomas", "status": "COMPLETED", "last_update": "2020-11-02", "phase": "PHASE2", "study_type": "INTERVENTIONAL" }, { "nct": "NCT01631331", "title": "Vismodegib in Treating Patients With Basal Cell Carcinoma (BCC)", "status": "COMPLETED", "last_update": "2017-12-08", "phase": "EARLY_PHASE1", "study_type": "INTERVENTIONAL" }, { "nct": "NCT01700049", "title": "Study Evaluating the Efficacy of Oral Vismodegib in Various Histologic Subtypes", "status": "COMPLETED", "last_update": "2019-05-23", "phase": "PHASE2", "study_type": "INTERVENTIONAL" }, { "nct": "NCT01815840", "title": "A Study of Two Vismodegib Regimens in Participants With Multiple Basal Cell Carcinomas", "status": "COMPLETED", "last_update": "2017-09-28", "phase": "PHASE2", "study_type": "INTERVENTIONAL" }, { "nct": "NCT01835626", "title": "Phase II Study of Radiation Therapy and Vismodegib for Advanced Head/Neck Basal Cell Carcinoma", "status": "COMPLETED", "last_update": "2021-05-03", "phase": "PHASE2", "study_type": "INTERVENTIONAL" }, { "nct": "NCT01893892", "title": "Levocarnitine in Treating Patients With Vismodegib-Associated Muscle Spasms", "status": "COMPLETED", "last_update": "2017-08-04", "phase": "NA", "study_type": "INTERVENTIONAL" }, { "nct": "NCT01898598", "title": "A Study of Vismodegib With Surgery in Participants With Previously Untreated Basal Cell Carcinoma", "status": "TERMINATED", "last_update": "2017-05-08", "phase": "PHASE2", "study_type": "INTERVENTIONAL" }, { "nct": "NCT02067104", "title": "Vismodegib in Basal Cell Carcinomas (BCC) Chemoprevention", "status": "TERMINATED", "last_update": "2019-08-14", "phase": "PHASE2", "study_type": "INTERVENTIONAL" }, { "nct": "NCT02436408", "title": "VISmodegib for ORbital and Periocular Basal Cell Carcinoma", "status": "COMPLETED", "last_update": "2021-10-28", "phase": "PHASE4", "study_type": "INTERVENTIONAL" }, { "nct": "NCT02639117", "title": "Photodynamic Therapy and Vismodegib for Multiple Basal Cell Carcinomas", "status": "COMPLETED", "last_update": "2018-07-18", "phase": "PHASE1", "study_type": "INTERVENTIONAL" }, { "nct": "NCT02667574", "title": "Study Evaluating the Interest of Vismodegib as Neo-adjuvant Treatment of Basal Cell Carcinoma (BCC)", "status": "COMPLETED", "last_update": "2026-04-22", "phase": "PHASE2", "study_type": "INTERVENTIONAL" }, { "nct": "NCT02690948", "title": "Pembrolizumab With or Without Vismodegib in Treating Metastatic or Unresectable Basal Cell Skin Cancer", "status": "COMPLETED", "last_update": "2019-03-08", "phase": "PHASE1/PHASE2", "study_type": "INTERVENTIONAL" }, { "nct": "NCT02956889", "title": "To Assess The Efficacy And Safety Of Vismodegib And Radiotherapy In Advanced Basal Cell Carcinoma", "status": "TERMINATED", "last_update": "2020-01-29", "phase": "PHASE2", "study_type": "INTERVENTIONAL" }, { "nct": "NCT03035188", "title": "Neoadjuvant Vismodegib in Patients With Large and/or Recurrent Resectable Basal Cell Carcinoma", "status": "COMPLETED", "last_update": "2022-02-11", "phase": "PHASE2", "study_type": "INTERVENTIONAL" }, { "nct": "NCT03610022", "title": "Relationship Between Pharmacokinetics and Safety of Vismodegib - OPTIVISMO-1", "status": "COMPLETED", "last_update": "2026-05-19", "phase": "PHASE4", "study_type": "INTERVENTIONAL" }, { "nct": "NCT03767439", "title": "Nivolumab With Vismodegib in Patients With Basal Cell Nevus Syndrome", "status": "WITHDRAWN", "last_update": "2019-12-18", "phase": "PHASE2", "study_type": "INTERVENTIONAL" }, { "nct": "NCT04416516", "title": "Safety and Efficacy of ASN-002 Combined With a Hedgehog Pathway Inhibitor", "status": "COMPLETED", "last_update": "2024-04-10", "phase": "PHASE2", "study_type": "INTERVENTIONAL" }, { "nct": "NCT06357988", "title": "Testing GDC-0449 (Vismodegib) as Potentially Targeted Treatment in Cancers With Smoothened or Patched 1 Mutant Tumors (MATCH - Subprotocol T)", "status": "ACTIVE_NOT_RECRUITING", "last_update": "2026-05-28", "phase": "PHASE2", "study_type": "INTERVENTIONAL" } ] } } } }