{"disease": {"name": "Cutaneous squamous cell carcinoma", "mondo_id": null, "ncit_id": null, "umls_id": null, "oncotree_code": "cscc"}, "updated_at": "2026-09-18", "genome_builds": ["hg19"], "cohort_count": 2, "cohort_count_status": "observed", "cohort_count_unit": "cohorts", "evaluable_patients": null, "evaluable_patients_status": "unknown", "evaluable_patients_unit": "patients", "alteration_types": ["SNV", "small indel", "amplification", "deep deletion"], "genes": [{"gene": "TP53", "alteration_types": ["SNV / small indel"], "altered": 55, "tested": 83, "frequency": 66.27, "cohort_count": 2, "frequency_range": {"min": 66.27, "max": 94.87}, "major_variants": ["R248Q (n=4)", "H179Y (n=3)", "E286K (n=3)", "G279E (n=2)", "R196* (n=2)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; 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the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Cutaneous Squamous Cell Carcinoma (UCSF, NPJ Genom Med 2021), 22/83 patients (26.51%).", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "cscc_ucsf_2021", "cohort_name": "Cutaneous Squamous Cell Carcinoma (UCSF, NPJ Genom Med 2021)", "altered": 22, "tested": 83, "frequency": 26.51, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "83/83", "coverage_note": null, "source_id": "cscc_ucsf_2021", "is_reference": true}, {"cohort": "cscc_hgsc_bcm_2014", "cohort_name": "Cutaneous Squamous Cell Carcinoma (MD Anderson, Clin Cancer Res 2014)", "altered": 19, "tested": 39, "frequency": 48.72, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "39/39", "coverage_note": null, "source_id": "cscc_hgsc_bcm_2014", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 88.37, "width": 11.63, "reference": 88.37, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 22, "tested": 83, "frequency": 26.51, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}], "variants": [], "genomic_events": [], "modality_summary": [{"modality": "SNV / small indel", "available_cohorts": 2, "total_cohorts": 2}, {"modality": "Copy number (discrete)", "available_cohorts": 0, "total_cohorts": 2}, {"modality": "Structural variant (present, not read)", "available_cohorts": 0, "total_cohorts": 2}], "chromosome_summary": [], "cohorts": [{"name": "Cutaneous Squamous Cell Carcinoma (UCSF, NPJ Genom Med 2021)", "source": "cBioPortal", "accession": "cscc_ucsf_2021", "patients": {"value": 83, "status": "observed", "unit": "patients"}, "samples": {"value": 83, "status": "observed", "unit": "samples"}, "disease_subtype": "Cutaneous Squamous Cell Carcinoma (UCSF, NPJ Genom Med 2021)", "assay_type": "exome or genome", "sequencing_method": "WES (83)", "genome_build": "hg19", "alteration_types_available": ["SNV", "small indel"], "genes_assayed": "all coding genes", "primary_or_metastatic": null, "age_group": null, "retrieved_at": "2026-09-18", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "source_record_id": "cscc_ucsf_2021", "is_demo": false, "assay_coverage": {"patients_with_calls": 83, "patients_in_roster": 83, "frequencies_computed": true, "samples_sequenced": 83, "samples_in_study": 83, "hypermutated_patients": 0, "median_mutations_per_sample": 620, "reason": null}}, {"name": "Cutaneous Squamous Cell Carcinoma (MD Anderson, Clin Cancer Res 2014)", "source": "cBioPortal", "accession": "cscc_hgsc_bcm_2014", "patients": {"value": 39, "status": "observed", "unit": "patients"}, "samples": {"value": 39, "status": "observed", "unit": "samples"}, "disease_subtype": "Cutaneous Squamous Cell Carcinoma (MD Anderson, Clin Cancer Res 2014)", "assay_type": "exome or genome", "sequencing_method": "WES (39)", "genome_build": "hg19", "alteration_types_available": ["SNV", "small indel"], "genes_assayed": "all coding genes", "primary_or_metastatic": null, "age_group": null, "retrieved_at": "2026-09-18", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "source_record_id": "cscc_hgsc_bcm_2014", "is_demo": false, "assay_coverage": {"patients_with_calls": 39, "patients_in_roster": 39, "frequencies_computed": true, "samples_sequenced": 39, "samples_in_study": 39, "hypermutated_patients": 0, "median_mutations_per_sample": 1349, "reason": null}}], "sources": [{"source_name": "cBioPortal · Cutaneous Squamous Cell Carcinoma (UCSF, NPJ Genom Med 2021)", "source_url": "https://www.cbioportal.org/study/summary?id=cscc_ucsf_2021", "source_record_id": "cscc_ucsf_2021", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Cutaneous Squamous Cell Carcinoma (MD Anderson, Clin Cancer Res 2014)", "source_url": "https://www.cbioportal.org/study/summary?id=cscc_hgsc_bcm_2014", "source_record_id": "cscc_hgsc_bcm_2014", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "limitations": ["A cBioPortal public-API snapshot retrieved 2026-09-18; the page does not refresh source data at request time.", "Counts are patients with at least one non-silent call in the study's sequenced sample list; silent, intronic and UTR calls are excluded.", "For targeted-panel cohorts each gene divides by the patients whose panel carried it; a gene absent from the panel is shown as not assayed, not as zero.", "Copy-number rows use discrete calls (2 = high-level amplification, −2 = deep deletion) against the cohort's copy-number sample list, which is a different roster from the sequenced one.", "Cohorts are not pooled. Cross-study patient overlap has not been checked and no disease-wide frequency is reported.", "Structural variants and fusions are not read in this snapshot even where the study carries a profile; germline variants, mutational signatures, TMB and MSI are not reported.", "The gene set is the briefing's curated targets plus the reference cohort's most frequently mutated genes; it is not genome-wide."], "answer_block": ["In Cutaneous Squamous Cell Carcinoma (UCSF, NPJ Genom Med 2021) (83 sequenced patients, exome or genome), the most frequently altered of the 48 genes shown are TP53 66.27%, NOTCH1 55.42%, RELN 46.99%, PKHD1 39.76%, PCDH15 38.55%. Each figure divides by the patients on whom that gene could be called.", "Of the briefing's 12 curated targets, 2 are altered in under 2% of this cohort (PDCD1, CD274): targets by expression, dependency or drug label, not by mutation. Frequency is not targetability, in either direction.", "2 cohorts are shown and none are pooled; overlap between them has not been checked and there is no disease-wide percentage."], "key_findings": [{"finding": "TP53 is mutated in 55 of 83 patients in Cutaneous Squamous Cell Carcinoma (UCSF, NPJ Genom Med 2021).", "numerator": 55, "denominator": 83, "frequency": 66.27, "cohorts": 2, "evidence_confidence": "moderate", "source": "cscc_ucsf_2021", "retrieved_at": "2026-09-18"}, {"finding": "NOTCH1 is mutated in 46 of 83 patients in Cutaneous Squamous Cell Carcinoma (UCSF, NPJ Genom Med 2021).", "numerator": 46, "denominator": 83, "frequency": 55.42, "cohorts": 2, "evidence_confidence": "moderate", "source": "cscc_ucsf_2021", "retrieved_at": "2026-09-18"}, {"finding": "RELN is mutated in 39 of 83 patients in Cutaneous Squamous Cell Carcinoma (UCSF, NPJ Genom Med 2021).", "numerator": 39, "denominator": 83, "frequency": 46.99, "cohorts": 2, "evidence_confidence": "moderate", "source": "cscc_ucsf_2021", "retrieved_at": "2026-09-18"}], "research_gaps": [{"kind": "Structural variants", "text": "Read the structural-variant profiles the studies carry; fusions are the defining event in several of these diseases."}, {"kind": "Context", "text": "Stage, subtype, age and treatment line are not attached to any count; the cohorts differ on all four."}, {"kind": "Interpretation", "text": "Activating versus inactivating, actionable versus not, and evidence level are not inferred here; the briefing's target table carries the drug and trial facts."}], "observations": [], "data_status": "PUBLIC SOURCE SNAPSHOT", "is_demo": false, "reference_cohort": "cscc_ucsf_2021", "region_events": [], "matrix": [{"label": "TP53", "kind": "SNV / small indel", "gene": "TP53", "cells": [{"cohort": "cscc_ucsf_2021", "status": "observed", "frequency": 66.27, "altered": 55, "tested": 83, "note": null}, {"cohort": "cscc_hgsc_bcm_2014", "status": "observed", "frequency": 94.87, "altered": 37, "tested": 39, "note": null}]}, {"label": "CDKN2A", "kind": "SNV / small indel", "gene": "CDKN2A", "cells": [{"cohort": "cscc_ucsf_2021", "status": "observed", "frequency": 26.51, "altered": 22, "tested": 83, "note": null}, {"cohort": "cscc_hgsc_bcm_2014", "status": "observed", "frequency": 43.59, "altered": 17, "tested": 39, "note": null}]}, {"label": "NOTCH1", "kind": "SNV / small indel", "gene": "NOTCH1", "cells": [{"cohort": "cscc_ucsf_2021", "status": "observed", "frequency": 55.42, "altered": 46, "tested": 83, "note": null}, {"cohort": "cscc_hgsc_bcm_2014", "status": "observed", "frequency": 58.97, "altered": 23, "tested": 39, "note": null}]}, {"label": "NOTCH2", "kind": "SNV / small indel", "gene": "NOTCH2", "cells": [{"cohort": "cscc_ucsf_2021", "status": "observed", "frequency": 36.14, "altered": 30, "tested": 83, "note": null}, {"cohort": "cscc_hgsc_bcm_2014", "status": "observed", "frequency": 51.28, "altered": 20, "tested": 39, "note": null}]}, {"label": "EGFR", "kind": "SNV / small indel", "gene": "EGFR", "cells": [{"cohort": "cscc_ucsf_2021", "status": "observed", "frequency": 7.23, "altered": 6, "tested": 83, "note": null}, {"cohort": "cscc_hgsc_bcm_2014", "status": "observed", "frequency": 7.69, "altered": 3, "tested": 39, "note": null}]}, {"label": "HRAS", "kind": "SNV / small indel", "gene": "HRAS", "cells": [{"cohort": "cscc_ucsf_2021", "status": "observed", "frequency": 12.05, "altered": 10, "tested": 83, "note": null}, {"cohort": "cscc_hgsc_bcm_2014", "status": "observed", "frequency": 20.51, "altered": 8, "tested": 39, "note": null}]}, {"label": "KMT2D", "kind": "SNV / small indel", "gene": "KMT2D", "cells": [{"cohort": "cscc_ucsf_2021", "status": "observed", "frequency": 24.1, "altered": 20, "tested": 83, "note": null}, {"cohort": "cscc_hgsc_bcm_2014", "status": "observed", "frequency": 71.79, "altered": 28, "tested": 39, "note": null}]}, {"label": "FAT1", "kind": "SNV / small indel", "gene": "FAT1", "cells": [{"cohort": "cscc_ucsf_2021", "status": "observed", "frequency": 30.12, "altered": 25, "tested": 83, "note": null}, {"cohort": "cscc_hgsc_bcm_2014", "status": "observed", "frequency": 46.15, "altered": 18, "tested": 39, "note": null}]}, {"label": "PDCD1", "kind": "SNV / small indel", "gene": "PDCD1", "cells": [{"cohort": "cscc_ucsf_2021", "status": "observed", "frequency": 1.2, "altered": 1, "tested": 83, "note": null}, {"cohort": "cscc_hgsc_bcm_2014", "status": "observed", "frequency": 20.51, "altered": 8, "tested": 39, "note": null}]}, {"label": "CD274", "kind": "SNV / small indel", "gene": "CD274", "cells": [{"cohort": "cscc_ucsf_2021", "status": "observed", "frequency": 1.2, "altered": 1, "tested": 83, "note": null}, {"cohort": "cscc_hgsc_bcm_2014", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 39, "note": null}]}, {"label": "TGFBR1", "kind": "SNV / small indel", "gene": "TGFBR1", "cells": [{"cohort": "cscc_ucsf_2021", "status": "observed", "frequency": 4.82, "altered": 4, "tested": 83, "note": null}, {"cohort": "cscc_hgsc_bcm_2014", "status": "observed", "frequency": 7.69, "altered": 3, "tested": 39, "note": null}]}, {"label": "CASP8", "kind": "SNV / small indel", "gene": "CASP8", "cells": [{"cohort": "cscc_ucsf_2021", "status": "observed", "frequency": 22.89, "altered": 19, "tested": 83, "note": null}, {"cohort": "cscc_hgsc_bcm_2014", "status": "observed", "frequency": 23.08, "altered": 9, "tested": 39, "note": null}]}, {"label": "RELN", "kind": "SNV / small indel", "gene": "RELN", "cells": [{"cohort": "cscc_ucsf_2021", "status": "observed", "frequency": 46.99, "altered": 39, "tested": 83, "note": null}, {"cohort": "cscc_hgsc_bcm_2014", "status": "observed", "frequency": 58.97, "altered": 23, "tested": 39, "note": null}]}, {"label": "PKHD1", "kind": "SNV / small indel", "gene": "PKHD1", "cells": [{"cohort": "cscc_ucsf_2021", "status": "observed", "frequency": 39.76, "altered": 33, "tested": 83, "note": null}, {"cohort": "cscc_hgsc_bcm_2014", "status": "observed", "frequency": 61.54, "altered": 24, "tested": 39, "note": null}]}, {"label": "PCDH15", "kind": "SNV / small indel", "gene": "PCDH15", "cells": [{"cohort": "cscc_ucsf_2021", "status": "observed", "frequency": 38.55, "altered": 32, "tested": 83, "note": null}, {"cohort": "cscc_hgsc_bcm_2014", "status": "observed", "frequency": 74.36, "altered": 29, "tested": 39, "note": null}]}, {"label": "COL6A3", "kind": "SNV / small indel", "gene": "COL6A3", "cells": [{"cohort": "cscc_ucsf_2021", "status": "observed", "frequency": 37.35, "altered": 31, "tested": 83, "note": null}, {"cohort": "cscc_hgsc_bcm_2014", "status": "observed", "frequency": 53.85, "altered": 21, "tested": 39, "note": null}]}, {"label": "KALRN", "kind": "SNV / small indel", "gene": "KALRN", "cells": [{"cohort": "cscc_ucsf_2021", "status": "observed", "frequency": 34.94, "altered": 29, "tested": 83, "note": null}, {"cohort": "cscc_hgsc_bcm_2014", "status": "observed", "frequency": 38.46, "altered": 15, "tested": 39, "note": null}]}, {"label": "DCHS2", "kind": "SNV / small indel", "gene": "DCHS2", "cells": [{"cohort": "cscc_ucsf_2021", "status": "observed", "frequency": 34.94, "altered": 29, "tested": 83, "note": null}, {"cohort": "cscc_hgsc_bcm_2014", "status": "observed", "frequency": 51.28, "altered": 20, "tested": 39, "note": null}]}, {"label": "COL24A1", "kind": "SNV / small indel", "gene": "COL24A1", "cells": [{"cohort": "cscc_ucsf_2021", "status": "observed", "frequency": 34.94, "altered": 29, "tested": 83, "note": null}, {"cohort": "cscc_hgsc_bcm_2014", "status": "observed", "frequency": 46.15, "altered": 18, "tested": 39, "note": null}]}, {"label": "LAMA2", "kind": "SNV / small indel", "gene": "LAMA2", "cells": [{"cohort": "cscc_ucsf_2021", "status": "observed", "frequency": 33.73, "altered": 28, "tested": 83, "note": null}, {"cohort": "cscc_hgsc_bcm_2014", "status": "observed", "frequency": 46.15, "altered": 18, "tested": 39, "note": null}]}, {"label": "FSIP2", "kind": "SNV / small indel", "gene": "FSIP2", "cells": [{"cohort": "cscc_ucsf_2021", "status": "observed", "frequency": 33.73, "altered": 28, "tested": 83, "note": null}, {"cohort": "cscc_hgsc_bcm_2014", "status": "observed", "frequency": 28.21, "altered": 11, "tested": 39, "note": null}]}, {"label": "BLTP1", "kind": "SNV / small indel", "gene": "BLTP1", "cells": [{"cohort": "cscc_ucsf_2021", "status": "observed", "frequency": 33.73, "altered": 28, "tested": 83, "note": null}, {"cohort": "cscc_hgsc_bcm_2014", "status": "observed", "frequency": 43.59, "altered": 17, "tested": 39, "note": null}]}, {"label": "MDN1", "kind": "SNV / small indel", "gene": "MDN1", "cells": [{"cohort": "cscc_ucsf_2021", "status": "observed", "frequency": 32.53, "altered": 27, "tested": 83, "note": null}, {"cohort": "cscc_hgsc_bcm_2014", "status": "observed", "frequency": 35.9, "altered": 14, "tested": 39, "note": null}]}, {"label": "KMT2C", "kind": "SNV / small indel", "gene": "KMT2C", "cells": [{"cohort": "cscc_ucsf_2021", "status": "observed", "frequency": 32.53, "altered": 27, "tested": 83, "note": null}, {"cohort": "cscc_hgsc_bcm_2014", "status": "observed", "frequency": 38.46, "altered": 15, "tested": 39, "note": null}]}, {"label": "ADGRB3", "kind": "SNV / small indel", "gene": "ADGRB3", "cells": [{"cohort": "cscc_ucsf_2021", "status": "observed", "frequency": 32.53, "altered": 27, "tested": 83, "note": null}, {"cohort": "cscc_hgsc_bcm_2014", "status": "observed", "frequency": 53.85, "altered": 21, "tested": 39, "note": null}]}, {"label": "VWF", "kind": "SNV / small indel", "gene": "VWF", "cells": [{"cohort": "cscc_ucsf_2021", "status": "observed", "frequency": 31.33, "altered": 26, "tested": 83, "note": null}, {"cohort": "cscc_hgsc_bcm_2014", "status": "observed", "frequency": 41.03, "altered": 16, "tested": 39, "note": null}]}, {"label": "ERICH3", "kind": "SNV / small indel", "gene": "ERICH3", "cells": [{"cohort": "cscc_ucsf_2021", "status": "observed", "frequency": 31.33, "altered": 26, "tested": 83, "note": null}, {"cohort": "cscc_hgsc_bcm_2014", "status": "observed", "frequency": 56.41, "altered": 22, "tested": 39, "note": null}]}, {"label": "ALMS1", "kind": "SNV / small indel", "gene": "ALMS1", "cells": [{"cohort": "cscc_ucsf_2021", "status": "observed", "frequency": 31.33, "altered": 26, "tested": 83, "note": null}, {"cohort": "cscc_hgsc_bcm_2014", "status": "observed", "frequency": 33.33, "altered": 13, "tested": 39, "note": null}]}, {"label": "SALL1", "kind": "SNV / small indel", "gene": "SALL1", "cells": [{"cohort": "cscc_ucsf_2021", "status": "observed", "frequency": 30.12, "altered": 25, "tested": 83, "note": null}, {"cohort": "cscc_hgsc_bcm_2014", "status": "observed", "frequency": 38.46, "altered": 15, "tested": 39, "note": null}]}, {"label": "ROS1", "kind": "SNV / small indel", "gene": "ROS1", "cells": [{"cohort": "cscc_ucsf_2021", "status": "observed", "frequency": 30.12, "altered": 25, "tested": 83, "note": null}, {"cohort": "cscc_hgsc_bcm_2014", "status": "observed", "frequency": 48.72, "altered": 19, "tested": 39, "note": null}]}, {"label": "FMN2", "kind": "SNV / small indel", "gene": "FMN2", "cells": [{"cohort": "cscc_ucsf_2021", "status": "observed", "frequency": 30.12, "altered": 25, "tested": 83, "note": null}, {"cohort": "cscc_hgsc_bcm_2014", "status": "observed", "frequency": 69.23, "altered": 27, "tested": 39, "note": null}]}, {"label": "FBN1", "kind": "SNV / small indel", "gene": "FBN1", "cells": [{"cohort": "cscc_ucsf_2021", "status": "observed", "frequency": 30.12, "altered": 25, "tested": 83, "note": null}, {"cohort": "cscc_hgsc_bcm_2014", "status": "observed", "frequency": 48.72, "altered": 19, "tested": 39, "note": null}]}, {"label": "PLCE1", "kind": "SNV / small indel", "gene": "PLCE1", "cells": [{"cohort": "cscc_ucsf_2021", "status": "observed", "frequency": 28.92, "altered": 24, "tested": 83, "note": null}, {"cohort": "cscc_hgsc_bcm_2014", "status": "observed", "frequency": 43.59, "altered": 17, "tested": 39, "note": null}]}, {"label": "DYNC1H1", "kind": "SNV / small indel", "gene": "DYNC1H1", "cells": [{"cohort": "cscc_ucsf_2021", "status": "observed", "frequency": 28.92, "altered": 24, "tested": 83, "note": null}, {"cohort": "cscc_hgsc_bcm_2014", "status": "observed", "frequency": 38.46, "altered": 15, "tested": 39, "note": null}]}, {"label": "UNC79", "kind": "SNV / small indel", "gene": "UNC79", "cells": [{"cohort": "cscc_ucsf_2021", "status": "observed", "frequency": 27.71, "altered": 23, "tested": 83, "note": null}, {"cohort": "cscc_hgsc_bcm_2014", "status": "observed", "frequency": 48.72, "altered": 19, "tested": 39, "note": null}]}, {"label": "SCN1A", "kind": "SNV / small indel", "gene": "SCN1A", "cells": [{"cohort": "cscc_ucsf_2021", "status": "observed", "frequency": 27.71, "altered": 23, "tested": 83, "note": null}, {"cohort": "cscc_hgsc_bcm_2014", "status": "observed", "frequency": 43.59, "altered": 17, "tested": 39, "note": null}]}, {"label": "PEG3", "kind": "SNV / small indel", "gene": "PEG3", "cells": [{"cohort": "cscc_ucsf_2021", "status": "observed", "frequency": 27.71, "altered": 23, "tested": 83, "note": null}, {"cohort": "cscc_hgsc_bcm_2014", "status": "observed", "frequency": 46.15, "altered": 18, "tested": 39, "note": null}]}, {"label": "NF1", "kind": "SNV / small indel", "gene": "NF1", "cells": [{"cohort": "cscc_ucsf_2021", "status": "observed", "frequency": 27.71, "altered": 23, "tested": 83, "note": null}, {"cohort": "cscc_hgsc_bcm_2014", "status": "observed", "frequency": 12.82, "altered": 5, "tested": 39, "note": null}]}, {"label": "MYO16", "kind": "SNV / small indel", "gene": "MYO16", "cells": [{"cohort": "cscc_ucsf_2021", "status": "observed", "frequency": 27.71, "altered": 23, "tested": 83, "note": null}, {"cohort": "cscc_hgsc_bcm_2014", "status": "observed", "frequency": 51.28, "altered": 20, "tested": 39, "note": null}]}, {"label": "MYO15A", "kind": "SNV / small indel", "gene": "MYO15A", "cells": [{"cohort": "cscc_ucsf_2021", "status": "observed", 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null}, {"cohort": "cscc_hgsc_bcm_2014", "status": "observed", "frequency": 17.95, "altered": 7, "tested": 39, "note": null}]}, {"label": "SLX4", "kind": "SNV / small indel", "gene": "SLX4", "cells": [{"cohort": "cscc_ucsf_2021", "status": "observed", "frequency": 26.51, "altered": 22, "tested": 83, "note": null}, {"cohort": "cscc_hgsc_bcm_2014", "status": "observed", "frequency": 20.51, "altered": 8, "tested": 39, "note": null}]}, {"label": "PLCB4", "kind": "SNV / small indel", "gene": "PLCB4", "cells": [{"cohort": "cscc_ucsf_2021", "status": "observed", "frequency": 26.51, "altered": 22, "tested": 83, "note": null}, {"cohort": "cscc_hgsc_bcm_2014", "status": "observed", "frequency": 23.08, "altered": 9, "tested": 39, "note": null}]}, {"label": "LAMA1", "kind": "SNV / small indel", "gene": "LAMA1", "cells": [{"cohort": "cscc_ucsf_2021", "status": "observed", "frequency": 26.51, "altered": 22, "tested": 83, "note": null}, {"cohort": "cscc_hgsc_bcm_2014", "status": "observed", 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