{
 "disease": "endometrial-cancer",
 "label": "Endometrial cancer",
 "url": "https://usebiotransfer.org/disease/endometrial-cancer/",
 "built": "2026-09-12",
 "facts_hash": {
  "answers": "1d7f3511590a",
  "targets": "9a911158cbed"
 },
 "sources": {
  "targets": "Open Targets Platform GraphQL API v4",
  "trials": "ClinicalTrials.gov API v2"
 },
 "retrieved": {
  "targets": "2026-09-12",
  "trials": "2026-09-12"
 },
 "query": {
  "endpoint": "https://clinicaltrials.gov/api/v2/studies",
  "shape": "query.cond=<disease>&query.intr=<term>&pageSize=200",
  "active_statuses": [
   "ACTIVE_NOT_RECRUITING",
   "ENROLLING_BY_INVITATION",
   "NOT_YET_RECRUITING",
   "RECRUITING"
  ],
  "dedup": "by NCT id across synonyms",
  "study_types": "interventional counted in headline; observational reported separately",
  "known_floor": "trials naming an antigen only by product code are not retrieved by an intervention-name search"
 },
 "targets": [
  {
   "symbol": "PTEN",
   "ensembl": "ENSG00000171862",
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   "n_distinct_drugs": 0,
   "drugs": {},
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    },
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    {
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     "bucket": "UniProt Ubiquitination"
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     "bucket": "Database Ubiquitination"
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     "bucket": "Half-life Data"
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    {
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     "bucket": "Small Molecule Binder"
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   ]
  },
  {
   "symbol": "PIK3CA",
   "ensembl": "ENSG00000121879",
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    "AZD-6482": "UNKNOWN",
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    "BGT-226": "PHASE_1_2",
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    "COPANLISIB": "APPROVAL",
    "DACTOLISIB": "PHASE_3",
    "DS-7423": "PHASE_1",
    "FIMEPINOSTAT": "PHASE_2",
    "GEDATOLISIB": "PHASE_3",
    "GSK-1059615": "PHASE_1",
    "INAVOLISIB": "APPROVAL",
    "IZORLISIB": "PHASE_1_2",
    "OMIPALISIB": "PHASE_1",
    "PANULISIB": "PHASE_1",
    "PAXALISIB": "PHASE_2_3",
    "PF-04691502": "PHASE_2",
    "PICTILISIB": "PHASE_2",
    "PILARALISIB": "PHASE_2",
    "PKI-179": "PHASE_1",
    "RECILISIB": "PHASE_1",
    "SAMOTOLISIB": "PHASE_2",
    "SERABELISIB": "PHASE_2",
    "SF-1126": "PHASE_2",
    "SONOLISIB": "PHASE_2",
    "TASELISIB": "PHASE_3",
    "VOXTALISIB": "PHASE_2",
    "VS-5584": "PHASE_1",
    "WX-037": "PHASE_1",
    "ZSTK-474": "PHASE_1"
   },
   "approved": [
    "ALPELISIB",
    "COPANLISIB",
    "INAVOLISIB"
   ],
   "n_approved": 3,
   "approved_for": {
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     "breast cancer",
     "breast neoplasm",
     "breast carcinoma"
    ],
    "COPANLISIB": [
     "follicular lymphoma",
     "non-Hodgkin lymphoma",
     "neoplasm of mature B-cells"
    ],
    "INAVOLISIB": [
     "breast neoplasm"
    ]
   },
   "tractability": [
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     "modality": "SM",
     "bucket": "Approved Drug"
    },
    {
     "modality": "SM",
     "bucket": "Structure with Ligand"
    },
    {
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     "bucket": "High-Quality Ligand"
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    {
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     "bucket": "High-Quality Pocket"
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    {
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     "bucket": "Druggable Family"
    },
    {
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     "bucket": "GO CC med conf"
    },
    {
     "modality": "PR",
     "bucket": "Literature"
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    {
     "modality": "PR",
     "bucket": "Database Ubiquitination"
    },
    {
     "modality": "PR",
     "bucket": "Half-life Data"
    },
    {
     "modality": "PR",
     "bucket": "Small Molecule Binder"
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   ]
  },
  {
   "symbol": "TP53",
   "ensembl": "ENSG00000141510",
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   "n_distinct_drugs": 8,
   "drugs": {
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    "CENERSEN": "PHASE_2",
    "CONTUSUGENE LADENOVEC": "PHASE_3",
    "EPRENETAPOPT": "PHASE_3",
    "IDASANUTLIN": "PHASE_3",
    "NAVTEMADLIN": "PHASE_3",
    "SIREMADLIN": "PHASE_2",
    "TEPRASIRAN": "PHASE_3"
   },
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   "n_approved": 0,
   "approved_for": {},
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     "bucket": "Advanced Clinical"
    },
    {
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     "bucket": "Structure with Ligand"
    },
    {
     "modality": "SM",
     "bucket": "High-Quality Ligand"
    },
    {
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     "bucket": "Med-Quality Pocket"
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    {
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     "bucket": "Druggable Family"
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     "bucket": "UniProt Ubiquitination"
    },
    {
     "modality": "PR",
     "bucket": "Database Ubiquitination"
    },
    {
     "modality": "PR",
     "bucket": "Small Molecule Binder"
    },
    {
     "modality": "OC",
     "bucket": "Advanced Clinical"
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   ]
  },
  {
   "symbol": "POLE",
   "ensembl": "ENSG00000177084",
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   "n_distinct_drugs": 6,
   "drugs": {
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    "CLOFARABINE": "APPROVAL",
    "CYTARABINE": "APPROVAL",
    "FLUDARABINE": "APPROVAL",
    "GEMCITABINE": "APPROVAL",
    "TROXACITABINE": "PHASE_2"
   },
   "approved": [
    "CLOFARABINE",
    "CYTARABINE",
    "FLUDARABINE",
    "GEMCITABINE"
   ],
   "n_approved": 4,
   "approved_for": {
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     "acute lymphoblastic leukemia",
     "myelodysplastic syndrome"
    ],
    "CYTARABINE": [
     "acute lymphoblastic leukemia",
     "acute myeloid leukemia",
     "leptomeningeal metastasis",
     "lymphoid leukemia",
     "tumor of meninges"
    ],
    "FLUDARABINE": [
     "B-cell chronic lymphocytic leukemia"
    ],
    "GEMCITABINE": [
     "non-small cell lung carcinoma",
     "exocrine pancreatic carcinoma",
     "ovarian carcinoma",
     "breast carcinoma",
     "breast cancer",
     "ovarian cancer"
    ]
   },
   "tractability": [
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     "modality": "SM",
     "bucket": "Approved Drug"
    },
    {
     "modality": "SM",
     "bucket": "Structure with Ligand"
    },
    {
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     "bucket": "Druggable Family"
    },
    {
     "modality": "AB",
     "bucket": "GO CC high conf"
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    {
     "modality": "AB",
     "bucket": "Human Protein Atlas loc"
    },
    {
     "modality": "PR",
     "bucket": "Database Ubiquitination"
    }
   ]
  },
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   "symbol": "MLH1",
   "ensembl": "ENSG00000076242",
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     "bucket": "Structure with Ligand"
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    {
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     "bucket": "Med-Quality Pocket"
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     "bucket": "UniProt Ubiquitination"
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    {
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     "bucket": "Database Ubiquitination"
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    {
     "modality": "PR",
     "bucket": "Half-life Data"
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   ]
  },
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   "symbol": "MSH2",
   "ensembl": "ENSG00000095002",
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     "bucket": "Structure with Ligand"
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    {
     "modality": "SM",
     "bucket": "High-Quality Pocket"
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    {
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     "bucket": "UniProt Ubiquitination"
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    {
     "modality": "PR",
     "bucket": "Database Ubiquitination"
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    {
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     "bucket": "Half-life Data"
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   ]
  },
  {
   "symbol": "MSH6",
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   "drugs": {},
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     "bucket": "Structure with Ligand"
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     "bucket": "High-Quality Pocket"
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    {
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     "bucket": "Half-life Data"
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   ]
  },
  {
   "symbol": "ARID1A",
   "ensembl": "ENSG00000117713",
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   "drugs": {},
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   "n_approved": 0,
   "approved_for": {},
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     "bucket": "Database Ubiquitination"
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    {
     "modality": "PR",
     "bucket": "Half-life Data"
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   ]
  },
  {
   "symbol": "CTNNB1",
   "ensembl": "ENSG00000168036",
   "n_drug_entries": 1,
   "n_distinct_drugs": 1,
   "drugs": {
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   "n_approved": 0,
   "approved_for": {},
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     "bucket": "Structure with Ligand"
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    {
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     "bucket": "High-Quality Ligand"
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    {
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     "bucket": "Druggable Family"
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    {
     "modality": "AB",
     "bucket": "UniProt loc high conf"
    },
    {
     "modality": "AB",
     "bucket": "GO CC high conf"
    },
    {
     "modality": "AB",
     "bucket": "Human Protein Atlas loc"
    },
    {
     "modality": "PR",
     "bucket": "UniProt Ubiquitination"
    },
    {
     "modality": "PR",
     "bucket": "Database Ubiquitination"
    },
    {
     "modality": "PR",
     "bucket": "Half-life Data"
    },
    {
     "modality": "PR",
     "bucket": "Small Molecule Binder"
    },
    {
     "modality": "OC",
     "bucket": "Advanced Clinical"
    }
   ]
  },
  {
   "symbol": "ESR1",
   "ensembl": "ENSG00000091831",
   "n_drug_entries": 51,
   "n_distinct_drugs": 43,
   "drugs": {
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    "AFIMOXIFENE": "PHASE_2",
    "AMCENESTRANT": "PHASE_3",
    "ARZOXIFENE": "APPROVAL",
    "BAZEDOXIFENE": "APPROVAL",
    "BRILANESTRANT": "PHASE_2",
    "CAMIZESTRANT": "PREAPPROVAL",
    "CHF4227": "PHASE_1",
    "CLOMIPHENE": "APPROVAL",
    "CYCLOFENIL": "APPROVAL",
    "DIENESTROL": "APPROVAL",
    "DIETHYLSTILBESTROL": "APPROVAL",
    "DIETHYLSTILBESTROL DIPHOSPHATE": "APPROVAL",
    "DROLOXIFENE": "PHASE_2",
    "ELACESTRANT": "APPROVAL",
    "ENCLOMIPHENE": "PHASE_2",
    "ESTETROL": "APPROVAL",
    "ESTRADIOL": "APPROVAL",
    "ESTRADIOL CYPIONATE": "APPROVAL",
    "ESTRADIOL VALERATE": "APPROVAL",
    "ESTRIOL": "APPROVAL",
    "ESTROGENS, CONJUGATED": "APPROVAL",
    "ESTROGENS, CONJUGATED SYNTHETIC A": "APPROVAL",
    "ESTROGENS, ESTERIFIED": "APPROVAL",
    "ESTRONE": "APPROVAL",
    "ESTROPIPATE": "APPROVAL",
    "ETHINYL ESTRADIOL": "APPROVAL",
    "FISPEMIFENE": "PHASE_2",
    "FULVESTRANT": "APPROVAL",
    "GIREDESTRANT": "PHASE_3",
    "GTX-758": "PHASE_2",
    "IDOXIFENE": "PHASE_3",
    "LASOFOXIFENE": "APPROVAL",
    "MESTRANOL": "APPROVAL",
    "MK-6913": "PHASE_2",
    "OSPEMIFENE": "APPROVAL",
    "POLYESTRADIOL": "APPROVAL",
    "QUINESTROL": "APPROVAL",
    "RALOXIFENE": "APPROVAL",
    "SYNTHETIC CONJUGATED ESTROGENS, B": "APPROVAL",
    "TAMOXIFEN": "APPROVAL",
    "TAS-108": "PHASE_2",
    "TOREMIFENE": "APPROVAL"
   },
   "approved": [
    "ARZOXIFENE",
    "BAZEDOXIFENE",
    "CLOMIPHENE",
    "CYCLOFENIL",
    "DIENESTROL",
    "DIETHYLSTILBESTROL",
    "DIETHYLSTILBESTROL DIPHOSPHATE",
    "ELACESTRANT",
    "ESTETROL",
    "ESTRADIOL",
    "ESTRADIOL CYPIONATE",
    "ESTRADIOL VALERATE",
    "ESTRIOL",
    "ESTROGENS, CONJUGATED",
    "ESTROGENS, CONJUGATED SYNTHETIC A",
    "ESTROGENS, ESTERIFIED",
    "ESTRONE",
    "ESTROPIPATE",
    "ETHINYL ESTRADIOL",
    "FULVESTRANT",
    "LASOFOXIFENE",
    "MESTRANOL",
    "OSPEMIFENE",
    "POLYESTRADIOL",
    "QUINESTROL",
    "RALOXIFENE",
    "SYNTHETIC CONJUGATED ESTROGENS, B",
    "TAMOXIFEN",
    "TOREMIFENE"
   ],
   "n_approved": 29,
   "approved_for": {
    "ARZOXIFENE": [
     "breast cancer"
    ],
    "BAZEDOXIFENE": [
     "osteopetrosis",
     "postmenopausal osteoporosis",
     "osteoporosis"
    ],
    "CLOMIPHENE": [
     "female infertility",
     "infertility disorder",
     "hemorrhage",
     "polycystic ovary syndrome"
    ],
    "CYCLOFENIL": [
     "Infertility"
    ],
    "DIENESTROL": [
     "Atrophic Vaginitis"
    ],
    "DIETHYLSTILBESTROL": [],
    "DIETHYLSTILBESTROL DIPHOSPHATE": [],
    "ELACESTRANT": [
     "breast cancer",
     "breast neoplasm",
     "male breast carcinoma"
    ],
    "ESTETROL": [
     "menopause",
     "pregnancy"
    ],
    "ESTRADIOL": [
     "menopause",
     "Atrophy",
     "hypogonadism",
     "Premature ovarian insufficiency",
     "osteoporosis",
     "Dyspareunia",
     "breast cancer",
     "primary ovarian failure",
     "postmenopausal atrophic vaginitis",
     "postmenopausal osteoporosis",
     "contraception",
     "leiomyoma"
    ],
    "ESTRADIOL CYPIONATE": [],
    "ESTRADIOL VALERATE": [
     "Menorrhagia",
     "hypogonadism",
     "Premature ovarian insufficiency",
     "menopause",
     "Atrophy",
     "primary ovarian failure"
    ],
    "ESTRIOL": [],
    "ESTROGENS, CONJUGATED": [
     "menopause",
     "Atrophy",
     "hypogonadism",
     "breast cancer",
     "primary ovarian failure",
     "osteoporosis",
     "Dyspareunia",
     "postmenopausal atrophic vaginitis",
     "postmenopausal osteoporosis"
    ],
    "ESTROGENS, CONJUGATED SYNTHETIC A": [
     "menopause",
     "Atrophy",
     "osteoporosis"
    ],
    "ESTROGENS, ESTERIFIED": [
     "breast cancer",
     "menopause",
     "Atrophy",
     "hypogonadism",
     "primary ovarian failure"
    ],
    "ESTRONE": [],
    "ESTROPIPATE": [
     "Atrophy",
     "hypogonadism",
     "menopause",
     "primary ovarian failure",
     "osteoporosis"
    ],
    "ETHINYL ESTRADIOL": [
     "acne",
     "endometriosis",
     "Dysmenorrhea",
     "contraception"
    ],
    "FULVESTRANT": [
     "breast cancer",
     "breast carcinoma",
     "breast neoplasm"
    ],
    "LASOFOXIFENE": [
     "postmenopausal osteoporosis",
     "osteoporosis"
    ],
    "MESTRANOL": [
     "contraception"
    ],
    "OSPEMIFENE": [
     "menopause",
     "Dyspareunia",
     "Atrophy",
     "postmenopausal atrophic vaginitis",
     "Atrophic Vaginitis"
    ],
    "POLYESTRADIOL": [
     "prostate cancer"
    ],
    "QUINESTROL": [
     "breast cancer"
    ],
    "RALOXIFENE": [
     "osteoporosis",
     "postmenopausal osteoporosis"
    ],
    "SYNTHETIC CONJUGATED ESTROGENS, B": [
     "Atrophy",
     "menopause"
    ],
    "TAMOXIFEN": [
     "breast cancer"
    ],
    "TOREMIFENE": [
     "breast cancer",
     "breast carcinoma",
     "breast neoplasm"
    ]
   },
   "tractability": [
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     "modality": "SM",
     "bucket": "Approved Drug"
    },
    {
     "modality": "SM",
     "bucket": "Structure with Ligand"
    },
    {
     "modality": "SM",
     "bucket": "High-Quality Ligand"
    },
    {
     "modality": "SM",
     "bucket": "High-Quality Pocket"
    },
    {
     "modality": "SM",
     "bucket": "Druggable Family"
    },
    {
     "modality": "AB",
     "bucket": "UniProt loc high conf"
    },
    {
     "modality": "AB",
     "bucket": "GO CC high conf"
    },
    {
     "modality": "AB",
     "bucket": "UniProt loc med conf"
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    {
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     "bucket": "Advanced Clinical"
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    {
     "modality": "PR",
     "bucket": "Literature"
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    {
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     "bucket": "Database Ubiquitination"
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    {
     "modality": "PR",
     "bucket": "Small Molecule Binder"
    },
    {
     "modality": "OC",
     "bucket": "Approved Drug"
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   ]
  },
  {
   "symbol": "PGR",
   "ensembl": "ENSG00000082175",
   "n_drug_entries": 31,
   "n_distinct_drugs": 28,
   "drugs": {
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    "CHLORMADINONE": "UNKNOWN",
    "CYPROTERONE": "PHASE_3",
    "DANAZOL": "APPROVAL",
    "DESOGESTREL": "APPROVAL",
    "DROSPIRENONE": "APPROVAL",
    "DYDROGESTERONE": "APPROVAL",
    "ETHYNODIOL DIACETATE": "APPROVAL",
    "ETONOGESTREL": "APPROVAL",
    "GESTODENE": "PHASE_3",
    "HYDROXYPROGESTERONE CAPROATE": "APPROVAL",
    "LEVONORGESTREL": "APPROVAL",
    "LONAPRISAN": "PHASE_2",
    "MEDROXYPROGESTERONE": "APPROVAL",
    "MEGESTROL": "APPROVAL",
    "MIFEPRISTONE": "APPROVAL",
    "NOMEGESTROL": "APPROVAL",
    "NORELGESTROMIN": "APPROVAL",
    "NORETHINDRONE": "APPROVAL",
    "NORGESTIMATE": "APPROVAL",
    "NORGESTREL": "APPROVAL",
    "ONAPRISTONE": "PHASE_2",
    "PROGESTERONE": "APPROVAL",
    "SEGESTERONE": "APPROVAL",
    "TELAPRISTONE": "PHASE_3",
    "TRIMEGESTONE": "APPROVAL",
    "ULIPRISTAL": "APPROVAL",
    "VILAPRISAN": "PHASE_3"
   },
   "approved": [
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    "DESOGESTREL",
    "DROSPIRENONE",
    "DYDROGESTERONE",
    "ETHYNODIOL DIACETATE",
    "ETONOGESTREL",
    "HYDROXYPROGESTERONE CAPROATE",
    "LEVONORGESTREL",
    "MEDROXYPROGESTERONE",
    "MEGESTROL",
    "MIFEPRISTONE",
    "NOMEGESTROL",
    "NORELGESTROMIN",
    "NORETHINDRONE",
    "NORGESTIMATE",
    "NORGESTREL",
    "PROGESTERONE",
    "SEGESTERONE",
    "TRIMEGESTONE",
    "ULIPRISTAL"
   ],
   "n_approved": 20,
   "approved_for": {
    "DANAZOL": [
     "breast fibrocystic disease",
     "endometriosis",
     "Menorrhagia"
    ],
    "DESOGESTREL": [
     "contraception"
    ],
    "DROSPIRENONE": [
     "acne",
     "Pain",
     "Dysmenorrhea",
     "endometriosis",
     "contraception"
    ],
    "DYDROGESTERONE": [
     "Menstrual disorder"
    ],
    "ETHYNODIOL DIACETATE": [
     "contraception"
    ],
    "ETONOGESTREL": [
     "contraception"
    ],
    "HYDROXYPROGESTERONE CAPROATE": [
     "premature birth"
    ],
    "LEVONORGESTREL": [
     "Menorrhagia",
     "osteoporosis",
     "contraception",
     "Dysmenorrhea",
     "hemorrhage"
    ],
    "MEDROXYPROGESTERONE": [
     "renal carcinoma",
     "endometriosis",
     "hemorrhage",
     "hyperplasia"
    ],
    "MEGESTROL": [
     "inborn error of immunity",
     "Anorexia",
     "Cachexia",
     "AIDS",
     "breast cancer"
    ],
    "MIFEPRISTONE": [
     "Cushing syndrome"
    ],
    "NOMEGESTROL": [
     "breast cancer",
     "contraception"
    ],
    "NORELGESTROMIN": [
     "contraception"
    ],
    "NORETHINDRONE": [
     "endometriosis",
     "Dysmenorrhea",
     "acne",
     "hypogonadism",
     "leiomyoma"
    ],
    "NORGESTIMATE": [
     "acne",
     "contraception"
    ],
    "NORGESTREL": [
     "Menorrhagia",
     "hemorrhage"
    ],
    "PROGESTERONE": [
     "amenorrhea",
     "atypical endometrial hyperplasia",
     "hemorrhage",
     "Infertility"
    ],
    "SEGESTERONE": [
     "contraception"
    ],
    "TRIMEGESTONE": [],
    "ULIPRISTAL": [
     "contraception",
     "Uterine leiomyoma"
    ]
   },
   "tractability": [
    {
     "modality": "SM",
     "bucket": "Approved Drug"
    },
    {
     "modality": "SM",
     "bucket": "Structure with Ligand"
    },
    {
     "modality": "SM",
     "bucket": "High-Quality Ligand"
    },
    {
     "modality": "SM",
     "bucket": "High-Quality Pocket"
    },
    {
     "modality": "SM",
     "bucket": "Druggable Family"
    },
    {
     "modality": "AB",
     "bucket": "GO CC high conf"
    },
    {
     "modality": "PR",
     "bucket": "UniProt Ubiquitination"
    },
    {
     "modality": "PR",
     "bucket": "Database Ubiquitination"
    },
    {
     "modality": "PR",
     "bucket": "Small Molecule Binder"
    }
   ]
  },
  {
   "symbol": "ERBB2",
   "ensembl": "ENSG00000141736",
   "n_drug_entries": 48,
   "n_distinct_drugs": 45,
   "drugs": {
    "AC-480": "PHASE_2",
    "AEE-788": "PHASE_1_2",
    "AFATINIB": "APPROVAL",
    "AFATINIB DIMALEATE": "APPROVAL",
    "ALLITINIB": "PHASE_1",
    "ANVATABART OPADOTIN": "PHASE_2_3",
    "AV-412": "PHASE_1",
    "BMS-690514": "PHASE_2",
    "CANERTINIB": "PHASE_2",
    "CP-724714": "PHASE_2",
    "CUDC-101": "PHASE_1",
    "DACOMITINIB": "APPROVAL",
    "DISITAMAB VEDOTIN": "PHASE_3",
    "ERTUMAXOMAB": "PHASE_2",
    "GANCOTAMAB": "PHASE_2_3",
    "HEMAY-022": "PHASE_3",
    "JNJ-26483327": "PHASE_1",
    "KBP5209": "PHASE_1",
    "KN-026": "PHASE_3",
    "LAPATINIB": "APPROVAL",
    "LAPATINIB DITOSYLATE": "APPROVAL",
    "MARGETUXIMAB": "APPROVAL",
    "MASOPROCOL": "APPROVAL",
    "MM-111": "PHASE_2",
    "MUBRITINIB": "PHASE_1",
    "NERATINIB": "APPROVAL",
    "PERTUZUMAB": "APPROVAL",
    "POZIOTINIB": "PHASE_3",
    "PYROTINIB": "PHASE_3",
    "S-222611": "PHASE_1",
    "SAPITINIB": "PHASE_2",
    "TAK-285": "PHASE_1",
    "TARLOXOTINIB": "PHASE_2",
    "TESEVATINIB": "PHASE_3",
    "TRASTUZUMAB": "APPROVAL",
    "TRASTUZUMAB BOTIDOTIN": "PHASE_3",
    "TRASTUZUMAB DERUXTECAN": "APPROVAL",
    "TRASTUZUMAB DUOCARMAZINE": "APPROVAL",
    "TRASTUZUMAB EMTANSINE": "APPROVAL",
    "TUCATINIB": "APPROVAL",
    "TUXOBERTINIB": "PHASE_1_2",
    "VANDETANIB": "APPROVAL",
    "VARLITINIB": "PHASE_2_3",
    "ZANIDATAMAB": "APPROVAL",
    "ZENOCUTUZUMAB": "APPROVAL"
   },
   "approved": [
    "AFATINIB",
    "AFATINIB DIMALEATE",
    "DACOMITINIB",
    "LAPATINIB",
    "LAPATINIB DITOSYLATE",
    "MARGETUXIMAB",
    "MASOPROCOL",
    "NERATINIB",
    "PERTUZUMAB",
    "TRASTUZUMAB",
    "TRASTUZUMAB DERUXTECAN",
    "TRASTUZUMAB DUOCARMAZINE",
    "TRASTUZUMAB EMTANSINE",
    "TUCATINIB",
    "VANDETANIB",
    "ZANIDATAMAB",
    "ZENOCUTUZUMAB"
   ],
   "n_approved": 17,
   "approved_for": {
    "AFATINIB": [
     "non-small cell lung carcinoma"
    ],
    "AFATINIB DIMALEATE": [
     "non-small cell lung carcinoma"
    ],
    "DACOMITINIB": [
     "non-small cell lung carcinoma"
    ],
    "LAPATINIB": [
     "breast cancer"
    ],
    "LAPATINIB DITOSYLATE": [
     "breast cancer",
     "breast neoplasm",
     "breast carcinoma"
    ],
    "MARGETUXIMAB": [
     "HER2 positive breast carcinoma",
     "breast cancer"
    ],
    "MASOPROCOL": [
     "prostate cancer"
    ],
    "NERATINIB": [
     "breast cancer",
     "breast neoplasm",
     "breast carcinoma"
    ],
    "PERTUZUMAB": [
     "breast cancer",
     "breast carcinoma",
     "breast neoplasm"
    ],
    "TRASTUZUMAB": [
     "breast cancer",
     "breast carcinoma",
     "gastric cancer",
     "gastric neoplasm",
     "breast neoplasm"
    ],
    "TRASTUZUMAB DERUXTECAN": [
     "breast cancer",
     "HER2 positive breast carcinoma",
     "breast neoplasm"
    ],
    "TRASTUZUMAB DUOCARMAZINE": [],
    "TRASTUZUMAB EMTANSINE": [
     "breast cancer",
     "breast carcinoma",
     "breast neoplasm"
    ],
    "TUCATINIB": [
     "HER2 positive breast carcinoma",
     "metastasis",
     "breast neoplasm",
     "breast cancer",
     "colorectal carcinoma",
     "breast carcinoma"
    ],
    "VANDETANIB": [
     "thyroid gland carcinoma",
     "medullary thyroid gland carcinoma",
     "thyroid tumor"
    ],
    "ZANIDATAMAB": [
     "biliary tract neoplasm"
    ],
    "ZENOCUTUZUMAB": [
     "non-small cell lung carcinoma",
     "pancreatic neoplasm"
    ]
   },
   "tractability": [
    {
     "modality": "SM",
     "bucket": "Approved Drug"
    },
    {
     "modality": "SM",
     "bucket": "Structure with Ligand"
    },
    {
     "modality": "SM",
     "bucket": "High-Quality Ligand"
    },
    {
     "modality": "SM",
     "bucket": "High-Quality Pocket"
    },
    {
     "modality": "SM",
     "bucket": "Druggable Family"
    },
    {
     "modality": "AB",
     "bucket": "Approved Drug"
    },
    {
     "modality": "AB",
     "bucket": "UniProt loc high conf"
    },
    {
     "modality": "AB",
     "bucket": "GO CC high conf"
    },
    {
     "modality": "AB",
     "bucket": "UniProt SigP or TMHMM"
    },
    {
     "modality": "AB",
     "bucket": "Human Protein Atlas loc"
    },
    {
     "modality": "PR",
     "bucket": "Literature"
    },
    {
     "modality": "PR",
     "bucket": "Database Ubiquitination"
    },
    {
     "modality": "PR",
     "bucket": "Half-life Data"
    },
    {
     "modality": "PR",
     "bucket": "Small Molecule Binder"
    },
    {
     "modality": "OC",
     "bucket": "Approved Drug"
    }
   ]
  }
 ],
 "trials": {
  "by_antigen": {
   "PD-1": {
    "n": 156,
    "n_observational": 4,
    "n_active": 93,
    "n_withdrawn": 6,
    "trials": [
     {
      "nct": "NCT01174121",
      "title": "Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic Cancer",
      "status": "RECRUITING",
      "last_update": "2026-09-01",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03651206",
      "title": "Recurrent Ovarian CarcinoSarcoma Anti-pd-1 Niraparib",
      "status": "RECRUITING",
      "last_update": "2026-09-09",
      "phase": "PHASE2/PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04014530",
      "title": "Pembrolizumab With Ataluren in Patients With Metastatic pMMR and dMMR Colorectal Carcinoma or Metastatic dMMR Endometrial Carcinoma: the ATAPEMBRO Study",
      "status": "RECRUITING",
      "last_update": "2023-02-01",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04585750",
      "title": "The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)",
      "status": "RECRUITING",
      "last_update": "2026-08-10",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04774419",
      "title": "Radiation and TSR-042 (Dostarlimab) in People With Endometrial Cancer After They Receive Surgery",
      "status": "RECRUITING",
      "last_update": "2026-07-09",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05086692",
      "title": "A Beta-only IL-2 ImmunoTherapY Study",
      "status": "RECRUITING",
      "last_update": "2025-07-09",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05092373",
      "title": "Phase I Study of Tumor Treating Fields (TTF) in Combination With Cabozantinib or With Pembrolizumab and Nab-Paclitaxel in Patients With Advanced Solid Tumors Involving the Abdomen or Thorax",
      "status": "RECRUITING",
      "last_update": "2026-07-16",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05123482",
      "title": "A Phase I/IIa Study of AZD8205 Given Alone or Combined, in Participants With Advanced/Metastatic Solid Malignancies",
      "status": "RECRUITING",
      "last_update": "2026-09-11",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05208762",
      "title": "A Study of PF-08046054/SGN-PDL1V in Advanced Solid Tumors",
      "status": "RECRUITING",
      "last_update": "2026-07-22",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05231122",
      "title": "Pembrolizumab Combined With Bevacizumab With or Without Agonist Anti-CD40 CDX-1140 for the Treatment of Patients With Recurrent Ovarian Cancer",
      "status": "RECRUITING",
      "last_update": "2026-08-14",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05269381",
      "title": "Personalized Neoantigen Peptide-Based Vaccine in Combination With Pembrolizumab for Treatment of Advanced Solid Tumors",
      "status": "RECRUITING",
      "last_update": "2026-08-20",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05410717",
      "title": "CLDN6/GPC3/Mesothelin/AXL-CAR-NK Cell Therapy for Advanced Solid Tumors",
      "status": "RECRUITING",
      "last_update": "2024-06-25",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05559879",
      "title": "Cabozantinib and Dostarlimab in Recurrent Gynecologic Carcinosarcoma",
      "status": "RECRUITING",
      "last_update": "2026-04-15",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05579366",
      "title": "Rinatabart Sesutecan (Rina-S, PRO1184, GEN1184) for Advanced Solid Tumors (GCT1184-01/ PRO1184-001)",
      "status": "RECRUITING",
      "last_update": "2026-08-04",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05603910",
      "title": "Phase 1 Clinical Trial of Lenvatinib, Pembrolizumab and Hypofractionated Pelvic Radiation Therapy for pMMR Recurrent/Unresectable Endometrial Carcinoma",
      "status": "RECRUITING",
      "last_update": "2026-08-03",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05669430",
      "title": "A Study of GV20-0251 Monotherapy and GV20-0251 in Combination With Pembrolizumab in Participants With Solid Tumor Malignancies",
      "status": "RECRUITING",
      "last_update": "2025-02-13",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05795244",
      "title": "Study of Induction PD-1 Blockade (Nivolumab) in Patients With Surgically Complete Resectable Mismatch Repair Deficient Endometrial Cancer (NIVEC)",
      "status": "RECRUITING",
      "last_update": "2025-05-13",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05797168",
      "title": "Phase I/IIa Study of AZD5335 as Monotherapy and Combination Therapy in Participants With Solid Tumors",
      "status": "RECRUITING",
      "last_update": "2026-08-21",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05819892",
      "title": "Phase I Trial Testing the Safety and Tolerability of Chemoradiation Followed by Chemotherapy + Dostarlimab for Stage IIIC, Node Positive, Endometrial Cancer",
      "status": "RECRUITING",
      "last_update": "2026-06-08",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05856981",
      "title": "Phase 1 Study Evaluating the Safety and PK of ADU-1805 in Advanced Solid Tumors",
      "status": "RECRUITING",
      "last_update": "2025-12-17",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05941507",
      "title": "A Study to Evaluate TROP2 ADC LCB84 Single Agent and in Combination With an Anti-PD-1 Ab in Advanced Solid Tumors",
      "status": "RECRUITING",
      "last_update": "2025-09-24",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06023862",
      "title": "A Three-arm Randomized Phase II Study of Dostarlimab Alone or With Bevacizumab Versus Nonplatinum Chemotherapy in Recurrent Gynecological Clear Cell Carcinoma: DOVE (APGOT-OV7/ ENGOT-ov80 Study)",
      "status": "RECRUITING",
      "last_update": "2026-05-06",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06253494",
      "title": "Pembrolizumab, Lenvatinib and IL-15 Superagonist N-803 in Combination With HER2 Targeting Autologous Dendritic Cell (AdHER2DC) Vaccine in Participants With Advanced or Metastatic Endometrial Cancer",
      "status": "RECRUITING",
      "last_update": "2026-04-09",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06270706",
      "title": "A Phase 1 Study of PLN-101095 in Adults With Advanced or Metastatic Solid Tumors",
      "status": "RECRUITING",
      "last_update": "2026-08-03",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06278857",
      "title": "SATELLITE Study (feaSibility sAfeTy Efficacy dostarLimab earLy-stage defIcient endomeTrial cancEr)",
      "status": "RECRUITING",
      "last_update": "2024-12-03",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06333314",
      "title": "Dostarlimab for Locally Advanced or Metastatic Cancer (Non-colorectal/Non-endometrial) With Tumor dMMR/MSI",
      "status": "RECRUITING",
      "last_update": "2025-12-02",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06366347",
      "title": "ALPINE: Maintenance Letrozole/Abemaciclib",
      "status": "RECRUITING",
      "last_update": "2026-02-11",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06400472",
      "title": "A Study of Sofe-M in Participants With Selected Advanced Solid Tumors",
      "status": "RECRUITING",
      "last_update": "2026-09-04",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06502743",
      "title": "First-line Carboplatin and Paclitaxel in Combination With Pembrolizumab, Followed by Maintenance Pembrolizumab With or Without Nesuparib, in Patients With Newly Diagnosed Advanced or Recurrent MMR-proficient (pMMR) Endometrial Cancer",
      "status": "RECRUITING",
      "last_update": "2025-04-03",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06522828",
      "title": "A Study to Evaluate SSGJ-707 in Advanced Gynecologic Cancer Patients",
      "status": "RECRUITING",
      "last_update": "2024-10-21",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06549855",
      "title": "PD-1 Inhibitor Combined With Progesterone Treatment in FST for Patients With MMRd Endometrial Cancer",
      "status": "RECRUITING",
      "last_update": "2026-08-10",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06561308",
      "title": "Clinical Efficacy Study of PD-1 Inhibitor Combined With Neoadjuvant Chemotherapy in Advanced Endometrial Cancer",
      "status": "RECRUITING",
      "last_update": "2026-07-29",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06638931",
      "title": "Agnostic Therapy in Rare Solid Tumors",
      "status": "RECRUITING",
      "last_update": "2026-04-15",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06730347",
      "title": "A Study of Lorigerlimab in Participants With Advanced Solid Tumors",
      "status": "RECRUITING",
      "last_update": "2026-06-02",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06917092",
      "title": "QL1706-Based Therapy Post-PD-1/L1 Failure in Advanced Endometrial Cancer",
      "status": "RECRUITING",
      "last_update": "2025-04-08",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06925724",
      "title": "A Study of Ivonescimab in People With Endometrial and Cervical Cancers",
      "status": "RECRUITING",
      "last_update": "2026-08-26",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06952504",
      "title": "A Study to Compare Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) Versus Pembrolizumab Alone as Treatment in Participants With Mismatch Repair Proficient Endometrial Cancer (MK-2870-033/TroFuse-033/GOG-3119/ENGOT-en29)",
      "status": "RECRUITING",
      "last_update": "2026-09-11",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06989112",
      "title": "DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer",
      "status": "RECRUITING",
      "last_update": "2026-09-03",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07044336",
      "title": "Puxitatug Samrotecan (AZD8205) Monotherapy vs Chemotherapy in B7-H4-selected Endometrial Cancer (Bluestar-Endometrial01)",
      "status": "RECRUITING",
      "last_update": "2026-07-29",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07046923",
      "title": "A Study of LY4175408 in Participants With Advanced Cancer",
      "status": "RECRUITING",
      "last_update": "2026-06-23",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07054567",
      "title": "A Study of BL-B01D1 + Pembrolizumab \u00b1 Bevacizumab in Patients With Recurrent or Metastatic Cervical Cancer and Endometrial Cancer",
      "status": "RECRUITING",
      "last_update": "2026-01-21",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07108270",
      "title": "A Study of Dostarlimab in Combination With Carboplatin-paclitaxel in Chinese Participants With Primary Advanced or Recurrent Endometrial Cancer (EC)",
      "status": "RECRUITING",
      "last_update": "2025-12-22",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07198074",
      "title": "Testing the Addition of an Antiangiogenic Drug (Bevacizumab) to Chemotherapy (Carboplatin and Paclitaxel) Combined With Immunotherapy (Pembrolizumab) for pMMR, TP53 Mutated Endometrial Cancer",
      "status": "RECRUITING",
      "last_update": "2026-09-04",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07227168",
      "title": "A Study of STRO-004 in Adults With Refractory/Recurrent Metastatic Cancer",
      "status": "RECRUITING",
      "last_update": "2026-08-27",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07262619",
      "title": "EIK1005-002: A Clinical Research Study Evaluating EIK1005, a Werner Helicase Inhibitor, as Monotherapy and in Combination With Pembrolizumab in Participants With Advanced Solid Tumors Including Microsatellite Instability High (MSI-H) Tumors",
      "status": "RECRUITING",
      "last_update": "2026-04-08",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07319429",
      "title": "Refining Fertility-sparing Treatment in Endometrial Carcinoma Based on Molecular Classification",
      "status": "RECRUITING",
      "last_update": "2026-03-13",
      "phase": "PHASE2/PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07594015",
      "title": "Pembrolizumab and Lenvatinib in Mismatch Repair Proficient Recurrent Endometrial Cancer After Failure of First-Line Therapy With Platinum-based Doublet and Immunotherapy",
      "status": "RECRUITING",
      "last_update": "2026-08-26",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07623369",
      "title": "A First-in-Human Study of HH160 in Participants With Advanced or Metastatic Solid Tumors",
      "status": "RECRUITING",
      "last_update": "2026-08-21",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02178722",
      "title": "Study to Explore the Safety, Tolerability and Efficacy of MK-3475 in Combination With INCB024360 in Participants With Selected Cancers",
      "status": "COMPLETED",
      "last_update": "2022-02-14",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02393248",
      "title": "Open-Label, Dose-Escalation Study of Pemigatinib in Subjects With Advanced Malignancies - (FIGHT-101)",
      "status": "TERMINATED",
      "last_update": "2023-01-06",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02521844",
      "title": "A Study to Evaluate the Safety and Tolerability of ETC-1922159 as a Single Agent and in Combination With Pembrolizumab in Advanced Solid Tumours",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2024-10-08",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02549209",
      "title": "Pembro/Carbo/Taxol in Endometrial Cancer",
      "status": "COMPLETED",
      "last_update": "2022-03-02",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02628067",
      "title": "Study of Pembrolizumab (MK-3475) in Participants With Advanced Solid Tumors (MK-3475-158/KEYNOTE-158)",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-09-22",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02630823",
      "title": "MK-3475 Immunotherapy in Endometrial Carcinoma",
      "status": "COMPLETED",
      "last_update": "2025-01-03",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02635672",
      "title": "Phase I Dose Escalation Study for VIP152 in Patients With Advanced Cancer",
      "status": "COMPLETED",
      "last_update": "2024-11-15",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02646748",
      "title": "Pembrolizumab Combined With Itacitinib (INCB039110) and/or Pembrolizumab Combined With INCB050465 in Advanced Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2022-03-31",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02715284",
      "title": "Study of TSR-042, an Anti-programmed Cell Death-1 Receptor (PD-1) Monoclonal Antibody, in Participants With Advanced Solid Tumors",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-08-25",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02728830",
      "title": "A Study of Pembrolizumab on the Tumoral Immunoprofile of Gynecologic Cancers",
      "status": "COMPLETED",
      "last_update": "2024-02-21",
      "phase": "EARLY_PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02834013",
      "title": "Nivolumab and Ipilimumab in Treating Patients With Rare Tumors",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-06-17",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02899793",
      "title": "Pembrolizumab in Ultramutated and Hypermutated Endometrial Cancer",
      "status": "COMPLETED",
      "last_update": "2025-06-11",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02922764",
      "title": "A Study of RGX-104 in Patients With Advanced Lung & Endometrial Cancer",
      "status": "COMPLETED",
      "last_update": "2025-03-26",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02982486",
      "title": "A Phase II of Nivolumab Plus Ipilimumab in Non-resectable Sarcoma and Endometrial Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2017-11-01",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03006887",
      "title": "Phase 1b Trial of Lenvatinib Plus Pembrolizumab in Participants With Selected Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2021-05-20",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03016338",
      "title": "Study of Niraparib and TSR-042 in Recurrent Endometrial Cancer",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-06-23",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03126110",
      "title": "Phase 1/2 Study Exploring the Safety, Tolerability, and Efficacy of INCAGN01876 Combined With Immune Therapies in Advanced or Metastatic Malignancies",
      "status": "COMPLETED",
      "last_update": "2025-08-14",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03170960",
      "title": "Study of Cabozantinib Alone or in Combination With Atezolizumab to Subjects With Locally Advanced or Metastatic Solid Tumors",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-08-17",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03192059",
      "title": "Study of Pembrolizumab, Radiation and Immune Modulatory Cocktail in Cervical/Uterine Cancer",
      "status": "COMPLETED",
      "last_update": "2021-09-08",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03212404",
      "title": "Phase 1 Study of CK-301 (Cosibelimab) as a Single Agent in Subjects With Advanced Cancers",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-02-03",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03241173",
      "title": "A Study Exploring the Safety and Efficacy of INCAGN01949 in Combination With Immune Therapies in Advanced or Metastatic Malignancies",
      "status": "COMPLETED",
      "last_update": "2022-09-27",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03276013",
      "title": "Pembrolizumab in Combination With Doxorubicin in Advanced, Recurrent or Metastatic Endometrial Cancer",
      "status": "COMPLETED",
      "last_update": "2021-10-05",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03277352",
      "title": "INCAGN01876 in Combination With Immune Therapies in Subjects With Advanced or Metastatic Malignancies",
      "status": "TERMINATED",
      "last_update": "2021-07-22",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03310567",
      "title": "A Study of Pembrolizumab in Combination With Epacadostat in Women With Recurrent/Metastatic Endometrial Carcinoma",
      "status": "WITHDRAWN",
      "last_update": "2018-10-09",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03454451",
      "title": "CPI-006 Alone and in Combination With Ciforadenant and With Pembrolizumab for Patients With Advanced Cancers",
      "status": "COMPLETED",
      "last_update": "2023-12-21",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03514121",
      "title": "FPA150 in Patients With Advanced Solid Tumors",
      "status": "TERMINATED",
      "last_update": "2024-11-22",
      "phase": "EARLY_PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03517449",
      "title": "Lenvatinib in Combination With Pembrolizumab Versus Treatment of Physician's Choice in Participants With Advanced Endometrial Cancer (MK-3475-775/E7080-G000-309 Per Merck Standard Convention [KEYNOTE-775])",
      "status": "COMPLETED",
      "last_update": "2026-03-19",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03629756",
      "title": "A Study to Evaluate the Safety and Tolerability of Immunotherapy Combinations in Participants With Advanced Malignancies",
      "status": "COMPLETED",
      "last_update": "2024-05-24",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03667716",
      "title": "COM701 (an Inhibitor of PVRIG) in Subjects With Advanced Solid Tumors.",
      "status": "COMPLETED",
      "last_update": "2025-01-17",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03694834",
      "title": "Window of Opportunity Pilot Study of Pembrolizumab in Obesity-driven Endometrial Cancer",
      "status": "TERMINATED",
      "last_update": "2023-11-28",
      "phase": "EARLY_PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03824704",
      "title": "A Study to Evaluate Rucaparib in Combination With Nivolumab in Patients With Selected Solid Tumors (ARIES)",
      "status": "TERMINATED",
      "last_update": "2023-06-12",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03827837",
      "title": "Famitinib Plus Anti-PD1 Therapy for Advanced Urinary System Tumor, Advanced Gynecological Tumors",
      "status": "UNKNOWN",
      "last_update": "2022-07-01",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03835819",
      "title": "A Phase 2 Study of Mirvetuximab Soravtansine (IMGN853) and Pembrolizumab in Endometrial Cancer (EC)",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-06-01",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03849469",
      "title": "A Study of XmAb\u00ae22841 Monotherapy & in Combination w/ Pembrolizumab in Subjects w/ Selected Advanced Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2023-03-30",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03860272",
      "title": "Fc-Engineered Anti-CTLA-4 Monoclonal Antibody in Advanced Cancer",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-03-30",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03884101",
      "title": "Pembrolizumab (MK-3475) Plus Lenvatinib (E7080/MK-7902) Versus Chemotherapy for Endometrial Carcinoma (ENGOT-en9 / MK-7902-001)",
      "status": "COMPLETED",
      "last_update": "2026-02-02",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03914612",
      "title": "Testing the Addition of the Immunotherapy Drug Pembrolizumab to the Usual Chemotherapy Treatment (Paclitaxel and Carboplatin) in Stage III-IV or Recurrent Endometrial Cancer",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-07-31",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03932409",
      "title": "Frontline Immunotherapy Combined With Radiation and Chemotherapy in High Risk Endometrial Cancer",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-05-08",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03955978",
      "title": "TSR-042 in Addition to Standard of Care Definitive Radiation for Inoperable Endometrial Cancer",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-01-06",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03981796",
      "title": "A Study to Evaluate Dostarlimab Plus Carboplatin-paclitaxel Versus Placebo Plus Carboplatin-paclitaxel in Participants With Recurrent or Primary Advanced Endometrial Cancer",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-09-03",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04042116",
      "title": "A Study to Evaluate Lucitanib in Combination With Nivolumab in Patients With a Solid Tumor",
      "status": "SUSPENDED",
      "last_update": "2022-12-20",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04044859",
      "title": "ADP-A2M4CD8 as Monotherapy or in Combination With Either Nivolumab or Pembrolizumab in HLA-A2+ Subjects With MAGE-A4 Positive Tumors (SURPASS)",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-08-12",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04046185",
      "title": "Programmed Death-1(PD-1) Inhibitor Combined With Progesterone Treatment in Endometrial Cancer",
      "status": "UNKNOWN",
      "last_update": "2019-08-06",
      "phase": "EARLY_PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04106414",
      "title": "Study of BMS-986205 and Nivolumab in Endometrial Cancer or Endometrial Carcinosarcoma That Has Not Responded to Treatment",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-10-14",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04152018",
      "title": "Study of PF-06940434 in Patients With Advanced or Metastatic Solid Tumors.",
      "status": "TERMINATED",
      "last_update": "2025-05-28",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04157491",
      "title": "Anti-PD-1 Antibody Combined With Anlotinib in the Treatment of Endometrial Cancer",
      "status": "UNKNOWN",
      "last_update": "2019-11-08",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04197219",
      "title": "Pembrolizumab With Axitinib in Recurrent Endometrial Cancer",
      "status": "WITHDRAWN",
      "last_update": "2020-11-05",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04214067",
      "title": "Testing the Addition of the Immunotherapy Drug, Pembrolizumab, to the Usual Radiation Treatment for Newly Diagnosed Early Stage High Intermediate Risk Endometrial Cancer",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-07-02",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04272034",
      "title": "Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of INCB099318 in Participants With Advanced Solid Tumors",
      "status": "TERMINATED",
      "last_update": "2025-10-16",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04278144",
      "title": "A First-in-human Study Using BDC-1001 as a Single Agent and in Combination With Nivolumab in Advanced HER2-Expressing Solid Tumors",
      "status": "TERMINATED",
      "last_update": "2025-09-15",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04344795",
      "title": "Phase 1a/1b Study of TPST-1495 as a Single Agent and in Combination With Pembrolizumab in Subjects With Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2025-09-12",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04458259",
      "title": "Study of PF-07265807 in Participants With Metastatic Solid Tumors.",
      "status": "TERMINATED",
      "last_update": "2026-06-04",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04460456",
      "title": "A Study of SBT6050 Alone and in Combination With PD-1 Inhibitors in Subjects With Advanced HER2 Expressing Solid Tumors",
      "status": "UNKNOWN",
      "last_update": "2022-06-30",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04463771",
      "title": "Safety and Efficacy of Retifanlimab (INCMGA00012) Alone or in Combination With Other Therapies in Participants With Advanced or Metastatic Endometrial Cancer Who Have Progressed on or After Platinum-based Chemotherapy.",
      "status": "COMPLETED",
      "last_update": "2026-06-11",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04485013",
      "title": "TTX-080 HLA-G Antagonist in Subjects With Advanced Cancers",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-09-11",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04574284",
      "title": "A Study of TQB2450 Injection Combined With Anlotinib Hydrochloride Capsule in Subjects With Advanced Endometrial Cancer",
      "status": "COMPLETED",
      "last_update": "2025-05-28",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04577963",
      "title": "A Study of Fruquintinib in Combination With Tislelizumab in Advanced Solid Tumors",
      "status": "TERMINATED",
      "last_update": "2025-07-14",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04611139",
      "title": "Pilot Trial of SP-2577 Plus Pembrolizumab in Select Gynecologic Cancers",
      "status": "WITHDRAWN",
      "last_update": "2022-03-02",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04631731",
      "title": "Risk Factors of Immune-ChEckpoint Inhibitors MEdiated Liver, Gastrointestinal, Endocrine and Skin Toxicity",
      "status": "UNKNOWN",
      "last_update": "2023-06-01",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04634877",
      "title": "Study of Pembrolizumab (MK-3475) in Combination With Adjuvant Chemotherapy With or Without Radiotherapy in Participants With Newly Diagnosed Endometrial Cancer After Surgery With Curative Intent (MK-3475-B21 / KEYNOTE-B21 / ENGOT-en11 / GOG-3053)",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-07-24",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04652076",
      "title": "GYNecological Cancers Treated with NETrin MAbs in Combination with Chemotherapy and /or Pembrolizumab",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2024-10-08",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04660929",
      "title": "CAR-macrophages for the Treatment of HER2 Overexpressing Solid Tumors",
      "status": "UNKNOWN",
      "last_update": "2024-12-18",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04781088",
      "title": "Lenvatinib, Pembrolizumab, and Paclitaxel for Treatment of Recurrent Endometrial, Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-02-11",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04865289",
      "title": "Pembrolizumab (MK-3475) Plus Lenvatinib (E7080/MK-7902) Versus Chemotherapy for Endometrial Carcinoma (ENGOT-en9 / MK-7902-001) - China Extension Study",
      "status": "COMPLETED",
      "last_update": "2025-12-02",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04870177",
      "title": "Study of AK112 in the Treatment of Advanced Gynecological Tumors",
      "status": "COMPLETED",
      "last_update": "2025-02-28",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04885413",
      "title": "An Open-label, Single Arm, Phase II Trial of Niraparib in Combination With Anti-PD1\uff08Programmed Cell Death Protein 1\uff09 Antibody in Recurrent/ Advanced Stage Endometrial Cancer Patients",
      "status": "UNKNOWN",
      "last_update": "2021-08-23",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04956640",
      "title": "Study of LY3537982 in Cancer Patients With a Specific Genetic Mutation (KRAS G12C)",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-05-29",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05007106",
      "title": "MK-7684A With or Without Other Anticancer Therapies in Participants With Selected Solid Tumors (MK-7684A-005) (KEYVIBE-005)",
      "status": "COMPLETED",
      "last_update": "2025-08-14",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05036681",
      "title": "A Phase II Study of Futibatinib and Pembrolizumab in Metastatic Microsatellite Stable Endometrial Carcinoma",
      "status": "TERMINATED",
      "last_update": "2026-03-27",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05069935",
      "title": "FT538 in Combination With Monoclonal Antibodies in Advanced Solid Tumors",
      "status": "TERMINATED",
      "last_update": "2023-09-21",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05077215",
      "title": "Efficacy and Safety of a Repurposed Drug Added to the Combination of Len Plus Pem in Advanced Endometrial Cancer",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2025-12-08",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05106127",
      "title": "Safety Lead-In Study of a Repurposed Drug Added to the Combination of Len Plus Pem",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2025-12-08",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05121363",
      "title": "A Clinical Trial to Evaluate TQB2858 Injection Combined With Anlotinib Hydrochloride Capsule in the Treatment of Recurrent or Metastatic Advanced Endometrial Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2021-11-30",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05156268",
      "title": "A Study of Pembrolizumab and Olaparib in People With Endometrial Cancer or Endometrial Carcinosarcoma",
      "status": "COMPLETED",
      "last_update": "2026-04-27",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05173987",
      "title": "Study of Pembrolizumab (MK-3475) Versus Chemotherapy in Mismatch Repair Deficient (dMMR) Advanced or Recurrent Endometrial Carcinoma (MK-3475-C93/KEYNOTE-C93/GOG-3064/ENGOT-en15)",
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      "last_update": "2026-05-05",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05194072",
      "title": "A Study of Felmetatug Vedotin/SGN-B7H4V in Advanced Solid Tumors",
      "status": "TERMINATED",
      "last_update": "2026-01-09",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05201547",
      "title": "Endometrial Cancer Patientes MMR Deficient Comparing Chemotherapy vs Dostarlimab in First Line",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-12-04",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05263492",
      "title": "Study of Lenvatinib w/ Pembro in Black Participants w/Mismatch Repair-Prof Recurrent Endometrial Cancer",
      "status": "TERMINATED",
      "last_update": "2025-10-02",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05277051",
      "title": "First-Time-in-Human Study of GSK4381562 in Participants With Advanced Solid Tumors",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-06-25",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05383482",
      "title": "Afuresertib +Sintilimab+Chemotherapy in Patients With Selected Solid Tumors That Resistance to Prior Anti-PD-1/PD-L1",
      "status": "COMPLETED",
      "last_update": "2025-11-17",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05419817",
      "title": "Pembrolizumab With Sitravatinib in Recurrent Endometrial Cancer and Other Solid Tumors With Deficient Mismatch Repair System",
      "status": "WITHDRAWN",
      "last_update": "2023-02-27",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05481645",
      "title": "Efficacy and Safety of TQB2450 Injection Combined With Chemotherapy \u00b1 Anlotinib Hydrochloride Capsules for Advanced Endometrial Cancer or Sarcoma of Uterus.",
      "status": "TERMINATED",
      "last_update": "2026-01-09",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05572684",
      "title": "A Safety, Tolerability and Efficacy Study of NC410 Plus Pembrolizumab in Participants With Advanced Unresectable or Metastatic Solid Tumors",
      "status": "TERMINATED",
      "last_update": "2026-08-13",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05714553",
      "title": "NUC-3373 in Combination With Other Agents in Patients With Advanced Solid Tumours",
      "status": "TERMINATED",
      "last_update": "2026-07-23",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05761951",
      "title": "Phase 2 Study Evaluating the Efficacy of the Combination of DKN-01 (DKK1 Inhibitor, Leap Therapeutics) and Pembrolizumab in the Treatment of Advanced or Recurrent Endometrial Cancer",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-05-19",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05787587",
      "title": "A Study of PARG Inhibitor IDE161 in Participants With Advanced Solid Tumors",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-07-13",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05812677",
      "title": "A Clinical Study on Oncolytic Virus Injection (R130) for the Treatment of Relapsed/Refractory Cervical and Endometrial Cancer",
      "status": "UNKNOWN",
      "last_update": "2023-04-14",
      "phase": "EARLY_PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05824481",
      "title": "Study of Cadonilimab (AK104) Plus Lenvatinib in Patients With Advanced Endometrial Cancer",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-03-10",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05858736",
      "title": "Safety, PK and Efficacy of AI-061 in Advanced Solid Tumors",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-04-09",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06036836",
      "title": "Study of Favezelimab Coformulated With Pembrolizumab (MK-4280A) in Participants With Selected Solid Tumors (MK-4280A-010)",
      "status": "COMPLETED",
      "last_update": "2026-03-19",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06046274",
      "title": "GEN1046 in Combination With Anticancer Agents for the Treatment of Advanced Endometrial Cancer",
      "status": "WITHDRAWN",
      "last_update": "2024-04-30",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06066216",
      "title": "Cadonilimab (AK104) Plus Chemotherapy in Patients With Recurrent or Advanced Endometrial Cancer",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2024-01-23",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06180733",
      "title": "Neo-adjuvant Pembrolizumab as an Alternative Treatment for MMRd Uterine Cancer",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-05-01",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06317311",
      "title": "A Study of Dostarlimab in Combination With Carboplatin-paclitaxel in Japanese Participants With Primary Advanced or Recurrent Endometrial Cancer",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-07-25",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06321068",
      "title": "BAT1308 in Combination With Platinum-containing Chemotherapy is Used for the First-line Treatment of Advanced or Recurrent dMMR Endometrial Cancer",
      "status": "TERMINATED",
      "last_update": "2025-08-14",
      "phase": "PHASE2/PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06385548",
      "title": "Efficacy and Safety Study of Lurbinectedin and Dostarlimab in Cancer Patients: Protocol VHIO21001 - LiDer",
      "status": "WITHDRAWN",
      "last_update": "2025-04-01",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06475599",
      "title": "Anlotinib Hydrochloride Capsules Combined With TQB2450 in the Treatment of Endometrial Cancer",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2024-06-27",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06486441",
      "title": "Study of Sacituzumab Govitecan Versus Treatment of Physician's Choice in Participants With Endometrial Cancer After Platinum-Based Chemotherapy and Immunotherapy (ASCENT-GYN-01/GOG-3104/ENGOT-en26)",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-07-29",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06607185",
      "title": "A Study of the Pan-KRAS Inhibitor LY4066434 in Participants With KRAS Mutant Solid Tumors",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-07-20",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06710847",
      "title": "A Study to Investigate the Safety, Pharmacokinetics, and Preliminary Effectiveness of GSK4418959 Alone or in Combination With Other Anti-cancer Agents in Participants With Solid Tumors",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-02-02",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06751277",
      "title": "QL1706 Combined with Chemotherapy in the Treatment of Recurrent or Metastatic Endometrial Cancer",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2024-12-27",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06897527",
      "title": "A Study to Evaluate the Safety of Dostarlimab in Adult Participants in India With Recurrent or Advanced Endometrial Cancer (EC)",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2025-07-08",
      "phase": "PHASE4",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07013851",
      "title": "Clinical Trial to Assess the Efficacy of Dostarlimab as Neoadjuvant Therapy in Patients With MMRd/MSI-H Stage II-III Endometrial Cancer",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2025-06-10",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07115927",
      "title": "pReOperative Dostarlimab and Novel Therapies in EndOmetrial Cancer",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2025-08-19",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07578649",
      "title": "Symbiotic-GYN-18: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Advanced or Recurrent MMR-proficient Endometrial Cancer",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2026-08-17",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07652515",
      "title": "A Study to Evaluate the Safety of Dostarlimab in Adult Participants in India With Primary Advanced or Recurrent Endometrial Cancer",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2026-06-17",
      "phase": "PHASE4",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07684599",
      "title": "A Study to Investigate Mocertatug Rezetecan as Maintenance Treatment for Participants With MMRp Endometrial Cancer (BEHOLD-Endometrial02)",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2026-09-01",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07807345",
      "title": "Phase 1 Study of STRO-006 in Adults With Refractory Solid Tumors That Are Recurrent or Metastatic",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2026-09-08",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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       "nct": "NCT01174121",
       "title": "Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic Cancer",
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       "last_update": "2026-09-01",
       "phase": "PHASE2",
       "study_type": "INTERVENTIONAL"
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      {
       "nct": "NCT05410717",
       "title": "CLDN6/GPC3/Mesothelin/AXL-CAR-NK Cell Therapy for Advanced Solid Tumors",
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       "last_update": "2024-06-25",
       "phase": "PHASE1",
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      "nct": "NCT04486352",
      "title": "A Study of Targeted Agents for Patients With Recurrent or Persistent Endometrial Cancer",
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      "last_update": "2026-04-01",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT05150691",
      "title": "A Phase 1/2a Study of DB-1303/BNT323 in Advanced/Metastatic Solid Tumors",
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      "last_update": "2026-08-27",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT05256225",
      "title": "Testing the Addition of Herceptin Hylecta or Phesgo to the Usual Chemotherapy for HER2 Positive Endometrial Serous Carcinoma or Carcinosarcoma",
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      "last_update": "2026-09-11",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT05579366",
      "title": "Rinatabart Sesutecan (Rina-S, PRO1184, GEN1184) for Advanced Solid Tumors (GCT1184-01/ PRO1184-001)",
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      "last_update": "2026-08-04",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05768139",
      "title": "First-in-Human Study of Tersolisib (STX-478) as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors",
      "status": "RECRUITING",
      "last_update": "2026-07-07",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05867251",
      "title": "Study of AVZO-021 in Patients With Advanced Solid Tumors",
      "status": "RECRUITING",
      "last_update": "2025-11-19",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06253494",
      "title": "Pembrolizumab, Lenvatinib and IL-15 Superagonist N-803 in Combination With HER2 Targeting Autologous Dendritic Cell (AdHER2DC) Vaccine in Participants With Advanced or Metastatic Endometrial Cancer",
      "status": "RECRUITING",
      "last_update": "2026-04-09",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06293898",
      "title": "Open Label Study to Evaluate BL-M07D1 in HER2 Expressing Malignant Solid Tumors",
      "status": "RECRUITING",
      "last_update": "2026-09-10",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06330064",
      "title": "A Study to Evaluate the Efficacy and Safety of Ifinatamab Deruxtecan (I-DXd) in Subjects With Recurrent or Metastatic Solid Tumors (IDeate-PanTumor02)",
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      "last_update": "2026-08-05",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06340568",
      "title": "A Clinical Study of the Anti-cancer Effects of an Investigational Therapy or Chemotherapy in Patients With Recurring Uterine Cancer",
      "status": "RECRUITING",
      "last_update": "2026-09-01",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06695845",
      "title": "A Phase 2 Study of Zanidatamab in Patients With HER2-expressing Tumors",
      "status": "RECRUITING",
      "last_update": "2026-07-10",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06760819",
      "title": "A Study to Learn More About How Well Treatment With Sevabertinib (BAY 2927088) Tablets Works and How Safe it is in Participants Who Have a Solid Tumor With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)",
      "status": "RECRUITING",
      "last_update": "2026-09-03",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06989112",
      "title": "DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer",
      "status": "RECRUITING",
      "last_update": "2026-09-03",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06993844",
      "title": "Phase 1/2 Study of ETX-636 in Participants With Advanced Solid Tumors",
      "status": "RECRUITING",
      "last_update": "2026-06-23",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07022483",
      "title": "Study of Trastuzumab Deruxtecan Versus Standard of Care Chemotherapy for HER2-Expressing (IHC 3+/2+) Endometrial Cancer",
      "status": "RECRUITING",
      "last_update": "2026-07-28",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07109726",
      "title": "A Phase 1/2 Trial of TER-2013 in Patients With Solid Tumors Harboring AKT/PI3K/PTEN Pathway Alterations",
      "status": "RECRUITING",
      "last_update": "2026-08-21",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07192068",
      "title": "Clinical Trial Evaluating the Activity of Zanidatamab for the Treatment of Patients With Solid Tumors With an Alteration of the HER2 Gene.",
      "status": "RECRUITING",
      "last_update": "2025-12-19",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07216105",
      "title": "FT836 With or Without Chemotherapy and/or Monoclonal Antibodies, in Participants With Advanced Solid Tumors",
      "status": "RECRUITING",
      "last_update": "2026-09-02",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07334119",
      "title": "Safety, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy of MT-304 in Adults With Advanced HER2-Expressing Solid Tumors",
      "status": "RECRUITING",
      "last_update": "2026-05-20",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07383506",
      "title": "A Study of Mutant Selective-Inhibitor (CGT6297), in Patients With Advanced Solid Tumors",
      "status": "RECRUITING",
      "last_update": "2026-08-26",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07524322",
      "title": "Study of RGT-490 in Patients With PIK3CA-Mutated Advanced Solid Tumors",
      "status": "RECRUITING",
      "last_update": "2026-07-22",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07612891",
      "title": "A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Antitumor Activity of INV-6452 in Adult Patients With Hormone Receptor Positive, Human Epidermal Growth Factor Receptor 2 Negative (HR+/HER2-) Advanced/Metastatic Breast Cancer or Locally Advanced/Metastatic Solid Tumor",
      "status": "RECRUITING",
      "last_update": "2026-05-29",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00004074",
      "title": "Interleukin-12 and Trastuzumab in Treating Patients With Cancer That Has High Levels of HER2/Neu",
      "status": "COMPLETED",
      "last_update": "2013-02-28",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00005842",
      "title": "Trastuzumab Plus R115777 in Treating Patients With Advanced or Metastatic Cancer",
      "status": "COMPLETED",
      "last_update": "2013-02-11",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00006089",
      "title": "Trastuzumab in Treating Patients With Stage III, Stage IV, or Recurrent Endometrial Cancer",
      "status": "COMPLETED",
      "last_update": "2019-07-31",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00028535",
      "title": "Interleukin-12, Paclitaxel, and Trastuzumab in Treating Patients With Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2013-06-04",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00031681",
      "title": "7-Hydroxystaurosporine and Irinotecan Hydrochloride in Treating Patients With Metastatic or Unresectable Solid Tumors or Triple Negative Breast Cancer (Currently Accruing Only Triple-negative Breast Cancer Patients Since 6/8/2007)",
      "status": "COMPLETED",
      "last_update": "2013-09-30",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01209195",
      "title": "A Study of MM-121 in Combination With Paclitaxel in Patients With Advanced Gynecologic and Breast Cancers",
      "status": "COMPLETED",
      "last_update": "2016-09-08",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01367002",
      "title": "Evaluation of Carboplatin/Paclitaxel With and Without Trastuzumab (Herceptin) in Uterine Serous Cancer",
      "status": "COMPLETED",
      "last_update": "2023-05-17",
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     {
      "nct": "NCT01454479",
      "title": "A Phase I Study of Lapatinib (Tykerb) Plus Ixabepilone (Ixempra) as 2nd-line Treatment for Patients With HER-2 Overexpressed Recurrent or Persistent Endometrial Carcinoma or Carcinosarcoma",
      "status": "UNKNOWN",
      "last_update": "2011-10-19",
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     {
      "nct": "NCT02025985",
      "title": "Study of KPT-330 (Selinexor) in Female Patients With Advanced Gynaecologic Malignancies",
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      "last_update": "2023-01-26",
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     {
      "nct": "NCT02393248",
      "title": "Open-Label, Dose-Escalation Study of Pemigatinib in Subjects With Advanced Malignancies - (FIGHT-101)",
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     {
      "nct": "NCT02465060",
      "title": "Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)",
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      "last_update": "2026-08-28",
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     {
      "nct": "NCT03746431",
      "title": "A Phase 1 Study of [225Ac]-FPI-1434 Injection",
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      "title": "Repeatability of 68-GaNOTA-Anti-HER2 VHH1 PET/CT in Breast Carcinoma Patients",
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     {
      "nct": "NCT04152499",
      "title": "Phase I-II, FIH, TROP2 ADC, Advanced Unresectable/Metastatic Solid Tumors, Refractory to Standard Therapies (KL264-01)",
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     {
      "nct": "NCT04188548",
      "title": "A Study of LY3484356 in Participants With Advanced or Metastatic Breast Cancer or Endometrial Cancer",
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      "phase": "PHASE1",
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     {
      "nct": "NCT04205630",
      "title": "SYD985 in Patients With HER2-expressing Recurrent, Advanced or Metastatic Endometrial Carcinoma",
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     {
      "nct": "NCT04209465",
      "title": "A Study of BDTX-189, an Orally Available Allosteric ErbB Inhibitor, in Patients With Advanced Solid Tumors.",
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     {
      "nct": "NCT04278144",
      "title": "A First-in-human Study Using BDC-1001 as a Single Agent and in Combination With Nivolumab in Advanced HER2-Expressing Solid Tumors",
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      "last_update": "2025-09-15",
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     {
      "nct": "NCT04319757",
      "title": "ACE1702 in Subjects With Advanced or Metastatic HER2-expressing Solid Tumors",
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      "last_update": "2024-12-05",
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      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT04460456",
      "title": "A Study of SBT6050 Alone and in Combination With PD-1 Inhibitors in Subjects With Advanced HER2 Expressing Solid Tumors",
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      "last_update": "2022-06-30",
      "phase": "PHASE1",
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     {
      "nct": "NCT04464967",
      "title": "Safety and Preliminary Efficacy of SNK01 in Combination With Trastuzumab or Cetuximab in Subjects With Advanced HER2 or EGFR Cancers",
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      "last_update": "2021-05-12",
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      "nct": "NCT04482309",
      "title": "A Phase 2 Study of T-DXd in Patients With Selected HER2 Expressing Tumors",
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      "nct": "NCT04485013",
      "title": "TTX-080 HLA-G Antagonist in Subjects With Advanced Cancers",
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      "nct": "NCT04498520",
      "title": "Abexinostat, Palbociclib, and Fulvestrant for the Treatment of Breast or Gynecologic Cancer",
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      "last_update": "2021-05-18",
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     {
      "nct": "NCT04513665",
      "title": "ZW25 in Women With Endometrial Cancers",
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      "last_update": "2025-05-22",
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      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04577963",
      "title": "A Study of Fruquintinib in Combination With Tislelizumab in Advanced Solid Tumors",
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      "last_update": "2025-07-14",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT04602117",
      "title": "ISPY-P1.01:Evaluating the Safety of Weekly Paclitaxel With Trastuzumab Duocarmazine (SYD985) in Patients With Metastatic Cancer",
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      "last_update": "2023-11-18",
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     {
      "nct": "NCT04639219",
      "title": "A Study of T-DXd for the Treatment of Solid Tumors Harboring HER2 Activating Mutations",
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      "last_update": "2026-03-23",
      "phase": "PHASE2",
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     {
      "nct": "NCT04644068",
      "title": "Study of AZD5305 as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Malignancies",
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      "last_update": "2026-08-19",
      "phase": "PHASE1/PHASE2",
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     {
      "nct": "NCT04660929",
      "title": "CAR-macrophages for the Treatment of HER2 Overexpressing Solid Tumors",
      "status": "UNKNOWN",
      "last_update": "2024-12-18",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT04665921",
      "title": "A Study of SGN-STNV in Advanced Solid Tumors",
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      "last_update": "2025-02-07",
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      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT04704661",
      "title": "Testing the Combination of Two Anti-cancer Drugs, DS-8201a and AZD6738, for The Treatment of Advanced Solid Tumors Expressing the HER2 Protein or Gene, The DASH Trial",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-09-04",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT05069935",
      "title": "FT538 in Combination With Monoclonal Antibodies in Advanced Solid Tumors",
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      "last_update": "2023-09-21",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT05143970",
      "title": "A Phase 1 First-In-Human Study of the Anti-CD73 IPH5301 Alone or in Combination With Chemotherapy and Trastuzumab in Patients With Advanced Solid Tumors",
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      "last_update": "2026-06-22",
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     {
      "nct": "NCT05194072",
      "title": "A Study of Felmetatug Vedotin/SGN-B7H4V in Advanced Solid Tumors",
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      "last_update": "2026-01-09",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT05238922",
      "title": "Study of INCB123667 in Subjects With Advanced Solid Tumors",
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      "last_update": "2026-07-21",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT05905341",
      "title": "Study of PF-07224826, as a Single Agent or in Combination With Endocrine Therapy in Participants With Breast Cancer and Other Advanced Solid Tumors.",
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      "last_update": "2023-11-08",
      "phase": "PHASE1",
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     {
      "nct": "NCT06003231",
      "title": "A Study of Disitamab Vedotin in Previously Treated Solid Tumors That Express HER2",
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      "last_update": "2026-07-22",
      "phase": "PHASE2",
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      "nct": "NCT06257264",
      "title": "A Study to Examine the Safety of Different Doses of BG-68501 Given to Participants With Advanced-Stage Tumors",
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      "phase": "PHASE1",
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     {
      "nct": "NCT06548763",
      "title": "Oral Topotecan With Toripalimab for Patients With Endometrial Cancer",
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      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06625515",
      "title": "First-in-Human Study of ATX-559, an Oral Inhibitor of DHX9, in Patients With Advanced or Metastatic Solid Tumors, and Molecularly Defined Cancers",
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      "last_update": "2026-02-24",
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     {
      "nct": "NCT06714617",
      "title": "Evaluate BL-M17D1 in Patients w/HER2-Expressing/Mutant Advanced or Metastatic Solid Tumors",
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      "phase": "PHASE1",
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     {
      "nct": "NCT07631871",
      "title": "An Exploratory Study of Zanidatamab in HER2-positive Advanced Tumor After at Least One Line of Standard Therapy",
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     {
      "nct": "NCT07631884",
      "title": "Exploratory Study on the Efficacy and Safety of Trastuzumab Rezetecan in the Treatment of HER2-Expressiong Advanced Solid Tumor",
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     {
      "nct": "NCT07811232",
      "title": "A Study of AL58805 in Advanced, Metastatic GYN, STS or Breast Cancers",
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      "nct": "NCT05489211",
      "title": "Study of Dato-DXd as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Tumours (TROPION-PanTumor03)",
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      "title": "A Study to Evaluate TROP2 ADC LCB84 Single Agent and in Combination With an Anti-PD-1 Ab in Advanced Solid Tumors",
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      "title": "Sacituzumab Govitecan in Combination With Cisplatin in Platinum Sensitive Recurrent Ovarian and Endometrial Cancer",
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      "title": "A Study to Compare Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) Versus Pembrolizumab Alone as Treatment in Participants With Mismatch Repair Proficient Endometrial Cancer (MK-2870-033/TroFuse-033/GOG-3119/ENGOT-en29)",
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      "nct": "NCT01631552",
      "title": "Study of Sacituzumab Govitecan-hziy (IMMU-132) in Adults With Epithelial Cancer",
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      "nct": "NCT04152499",
      "title": "Phase I-II, FIH, TROP2 ADC, Advanced Unresectable/Metastatic Solid Tumors, Refractory to Standard Therapies (KL264-01)",
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      "nct": "NCT04251416",
      "title": "A Study of Sacituzumab Govitecan (IMMU-132) in Endometrial Carcinoma",
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      "title": "Sacituzumab Tirumotecan (MK-2870) in Post Platinum and Post Immunotherapy Endometrial Cancer (MK-2870-005)",
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      "title": "Sacituzumab Govitecan for Relapsed Ovarian, Endometrial, and Cervical Carcinomas",
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      "nct": "NCT03832361",
      "title": "Evaluation of Mirvetuximab Soravtansine (IMGN853) in Women With Folate Receptor-\u03b1 Positive Endometrial Cancer",
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     {
      "nct": "NCT04300556",
      "title": "A Study to Evaluate the Safety, Tolerability, and Efficacy of MORAb-202 (Herein Referred to as Farletuzumab Ecteribulin), a Folate Receptor Alpha (FR\u03b1)-Targeting Antibody-drug Conjugate (ADC) in Participants With Selected Tumor Types",
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      "nct": "NCT05579366",
      "title": "Rinatabart Sesutecan (Rina-S, PRO1184, GEN1184) for Advanced Solid Tumors (GCT1184-01/ PRO1184-001)",
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      "title": "A Study of MOv18 IgE in Patients With Solid Tumours That Express Folate Receptor Alpha",
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      "nct": "NCT02996825",
      "title": "Mirvetuximab Soravtansine and Gemcitabine Hydrochloride in Treating Patients With FRalpha-Positive Recurrent Ovarian, Primary Peritoneal, Fallopian Tube, Endometrial, or Triple Negative Breast Cancer",
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     {
      "nct": "NCT03552471",
      "title": "Mirvetuximab Soravtansine and Rucaparib Camsylate in Treating Participants With Recurrent Endometrial, Ovarian, Fallopian Tube or Primary Peritoneal Cancer",
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     {
      "nct": "NCT03748186",
      "title": "Study of STRO-002, an Anti-Folate Receptor Alpha (FolR\u03b1) Antibody Drug Conjugate in Ovarian & Endometrial Cancers",
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      "last_update": "2025-08-20",
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     {
      "nct": "NCT03835819",
      "title": "A Phase 2 Study of Mirvetuximab Soravtansine (IMGN853) and Pembrolizumab in Endometrial Cancer (EC)",
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      "last_update": "2026-06-01",
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     {
      "nct": "NCT03836157",
      "title": "Mirvetuximab Soravtansine (IMGN853) and Bevacizumab in Patients With Endometrial Cancer",
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      "last_update": "2019-06-27",
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     {
      "nct": "NCT05001282",
      "title": "A Study to Evaluate ELU001 in Patients With Solid Tumors That Overexpress Folate Receptor Alpha (FR\u03b1)",
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     {
      "nct": "NCT05498597",
      "title": "AMT-151 in Patients With Selected Advanced Solid Tumours",
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      "last_update": "2023-10-19",
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     {
      "nct": "NCT06014190",
      "title": "HS-20089 in Patients With Ovarian Cancer and Endometrial Cancer",
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      "last_update": "2024-08-29",
      "phase": "PHASE2",
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     {
      "nct": "NCT06774963",
      "title": "A Phase 1 Study of LNCB74 in Advanced Solid Tumors",
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      "last_update": "2026-08-21",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT07044336",
      "title": "Puxitatug Samrotecan (AZD8205) Monotherapy vs Chemotherapy in B7-H4-selected Endometrial Cancer (Bluestar-Endometrial01)",
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      "last_update": "2026-07-29",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT03514121",
      "title": "FPA150 in Patients With Advanced Solid Tumors",
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      "last_update": "2024-11-22",
      "phase": "EARLY_PHASE1",
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      "nct": "NCT06003231",
      "title": "A Study of Disitamab Vedotin in Previously Treated Solid Tumors That Express HER2",
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      "title": "First-in-Human Study of Tersolisib (STX-478) as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors",
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      "title": "Phase 1/2 Study of ETX-636 in Participants With Advanced Solid Tumors",
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     {
      "nct": "NCT07109726",
      "title": "A Phase 1/2 Trial of TER-2013 in Patients With Solid Tumors Harboring AKT/PI3K/PTEN Pathway Alterations",
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      "last_update": "2026-08-21",
      "phase": "PHASE1/PHASE2",
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     {
      "nct": "NCT00002976",
      "title": "Estrogen Replacement Therapy in Treating Women With Early-Stage Endometrial Cancer",
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      "last_update": "2013-04-11",
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      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00006903",
      "title": "Fulvestrant in Treating Patients With Recurrent, Persistent, or Metastatic Endometrial Cancer",
      "status": "UNKNOWN",
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      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00033358",
      "title": "Hormone Therapy in Preventing Endometrial Cancer in Patients With a Genetic Risk For Hereditary Nonpolyposis Colon Cancer",
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      "last_update": "2013-05-03",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00334295",
      "title": "Fulvestrant for the Treatment of Recurrent or Metastatic Endometrial Carcinoma.",
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      "last_update": "2012-07-31",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00919919",
      "title": "Efficacy and Tolerability Study of Progesterone Vaginal Tablets (Endometrin\u00ae) in Menopausal Women Treated by Estrogen",
      "status": "UNKNOWN",
      "last_update": "2009-06-12",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT02872818",
      "title": "Apoptotic Signaling Pathways in Rats With Endometrial Hyperplasia",
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      "last_update": "2016-08-23",
      "phase": "PHASE4",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03643510",
      "title": "Evaluating Cancer Response to Treatment With Abemaciclib and Fulvestrant in Women With Recurrent Endometrial Cancer",
      "status": "COMPLETED",
      "last_update": "2026-03-16",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03926936",
      "title": "FUlvestrant in Gynecological Cancers That Are Potentially Hormone Sensitive: the FUCHSia Study",
      "status": "COMPLETED",
      "last_update": "2024-05-28",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04002635",
      "title": "Letrozole for Frozen Embryo Transfer (FET) in Patients With Polycystic Ovary Syndrome (PCOS)",
      "status": "WITHDRAWN",
      "last_update": "2021-01-08",
      "phase": "PHASE4",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04498520",
      "title": "Abexinostat, Palbociclib, and Fulvestrant for the Treatment of Breast or Gynecologic Cancer",
      "status": "WITHDRAWN",
      "last_update": "2021-05-18",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05082025",
      "title": "Phase 2 Study of PI3K Inhibitor Copanlisib in Combination With Fulvestrant in Selected ER+ and/or PR+ Cancers With PI3K (PIK3CA, PIK3R1) and/or PTEN Alterations",
      "status": "TERMINATED",
      "last_update": "2026-01-09",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05154487",
      "title": "A Study of Alpelisib and Fulvestrant to Treat Endometrial Cancer",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-07-30",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05189873",
      "title": "GnRH Agonist Plus Hormone Replacement Therapy vs Hormone Replacement Therapy on IVF Outcomes",
      "status": "COMPLETED",
      "last_update": "2022-01-13",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05238922",
      "title": "Study of INCB123667 in Subjects With Advanced Solid Tumors",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-07-21",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05252416",
      "title": "(VELA) Study of BLU-222 in Advanced Solid Tumors",
      "status": "TERMINATED",
      "last_update": "2025-11-28",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05905341",
      "title": "Study of PF-07224826, as a Single Agent or in Combination With Endocrine Therapy in Participants With Breast Cancer and Other Advanced Solid Tumors.",
      "status": "WITHDRAWN",
      "last_update": "2023-11-08",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06257264",
      "title": "A Study to Examine the Safety of Different Doses of BG-68501 Given to Participants With Advanced-Stage Tumors",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-06-18",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07038369",
      "title": "A Phase 1 Study of ATV-1601 in Patients With Advanced Cancer That Have AKT1 E17K Mutations",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-08-07",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07811232",
      "title": "A Study of AL58805 in Advanced, Metastatic GYN, STS or Breast Cancers",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2026-09-10",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     }
    ]
   },
   "ESTRADIOL CYPIONATE": {
    "n": 25,
    "n_observational": 2,
    "n_active": 11,
    "n_withdrawn": 3,
    "trials": [
     {
      "nct": "NCT05316935",
      "title": "GnRHa + Letrozole in Non-obese Progestin-insensitive Endometrial Cancer and Atypical Hyperplasia Patients",
      "status": "RECRUITING",
      "last_update": "2026-09-10",
      "phase": "PHASE2/PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05564377",
      "title": "Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial",
      "status": "RECRUITING",
      "last_update": "2026-09-11",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05768139",
      "title": "First-in-Human Study of Tersolisib (STX-478) as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors",
      "status": "RECRUITING",
      "last_update": "2026-07-07",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05867251",
      "title": "Study of AVZO-021 in Patients With Advanced Solid Tumors",
      "status": "RECRUITING",
      "last_update": "2025-11-19",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06993844",
      "title": "Phase 1/2 Study of ETX-636 in Participants With Advanced Solid Tumors",
      "status": "RECRUITING",
      "last_update": "2026-06-23",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07109726",
      "title": "A Phase 1/2 Trial of TER-2013 in Patients With Solid Tumors Harboring AKT/PI3K/PTEN Pathway Alterations",
      "status": "RECRUITING",
      "last_update": "2026-08-21",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00002976",
      "title": "Estrogen Replacement Therapy in Treating Women With Early-Stage Endometrial Cancer",
      "status": "TERMINATED",
      "last_update": "2013-04-11",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00006903",
      "title": "Fulvestrant in Treating Patients With Recurrent, Persistent, or Metastatic Endometrial Cancer",
      "status": "UNKNOWN",
      "last_update": "2019-03-20",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00033358",
      "title": "Hormone Therapy in Preventing Endometrial Cancer in Patients With a Genetic Risk For Hereditary Nonpolyposis Colon Cancer",
      "status": "COMPLETED",
      "last_update": "2013-05-03",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00334295",
      "title": "Fulvestrant for the Treatment of Recurrent or Metastatic Endometrial Carcinoma.",
      "status": "COMPLETED",
      "last_update": "2012-07-31",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00919919",
      "title": "Efficacy and Tolerability Study of Progesterone Vaginal Tablets (Endometrin\u00ae) in Menopausal Women Treated by Estrogen",
      "status": "UNKNOWN",
      "last_update": "2009-06-12",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02872818",
      "title": "Apoptotic Signaling Pathways in Rats With Endometrial Hyperplasia",
      "status": "COMPLETED",
      "last_update": "2016-08-23",
      "phase": "PHASE4",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03643510",
      "title": "Evaluating Cancer Response to Treatment With Abemaciclib and Fulvestrant in Women With Recurrent Endometrial Cancer",
      "status": "COMPLETED",
      "last_update": "2026-03-16",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03926936",
      "title": "FUlvestrant in Gynecological Cancers That Are Potentially Hormone Sensitive: the FUCHSia Study",
      "status": "COMPLETED",
      "last_update": "2024-05-28",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04002635",
      "title": "Letrozole for Frozen Embryo Transfer (FET) in Patients With Polycystic Ovary Syndrome (PCOS)",
      "status": "WITHDRAWN",
      "last_update": "2021-01-08",
      "phase": "PHASE4",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04498520",
      "title": "Abexinostat, Palbociclib, and Fulvestrant for the Treatment of Breast or Gynecologic Cancer",
      "status": "WITHDRAWN",
      "last_update": "2021-05-18",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05082025",
      "title": "Phase 2 Study of PI3K Inhibitor Copanlisib in Combination With Fulvestrant in Selected ER+ and/or PR+ Cancers With PI3K (PIK3CA, PIK3R1) and/or PTEN Alterations",
      "status": "TERMINATED",
      "last_update": "2026-01-09",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05154487",
      "title": "A Study of Alpelisib and Fulvestrant to Treat Endometrial Cancer",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-07-30",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05189873",
      "title": "GnRH Agonist Plus Hormone Replacement Therapy vs Hormone Replacement Therapy on IVF Outcomes",
      "status": "COMPLETED",
      "last_update": "2022-01-13",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05238922",
      "title": "Study of INCB123667 in Subjects With Advanced Solid Tumors",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-07-21",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05252416",
      "title": "(VELA) Study of BLU-222 in Advanced Solid Tumors",
      "status": "TERMINATED",
      "last_update": "2025-11-28",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05905341",
      "title": "Study of PF-07224826, as a Single Agent or in Combination With Endocrine Therapy in Participants With Breast Cancer and Other Advanced Solid Tumors.",
      "status": "WITHDRAWN",
      "last_update": "2023-11-08",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06257264",
      "title": "A Study to Examine the Safety of Different Doses of BG-68501 Given to Participants With Advanced-Stage Tumors",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-06-18",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07038369",
      "title": "A Phase 1 Study of ATV-1601 in Patients With Advanced Cancer That Have AKT1 E17K Mutations",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-08-07",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07811232",
      "title": "A Study of AL58805 in Advanced, Metastatic GYN, STS or Breast Cancers",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2026-09-10",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     }
    ]
   },
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     {
      "nct": "NCT05316935",
      "title": "GnRHa + Letrozole in Non-obese Progestin-insensitive Endometrial Cancer and Atypical Hyperplasia Patients",
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      "last_update": "2026-09-10",
      "phase": "PHASE2/PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05564377",
      "title": "Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial",
      "status": "RECRUITING",
      "last_update": "2026-09-11",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05768139",
      "title": "First-in-Human Study of Tersolisib (STX-478) as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors",
      "status": "RECRUITING",
      "last_update": "2026-07-07",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05867251",
      "title": "Study of AVZO-021 in Patients With Advanced Solid Tumors",
      "status": "RECRUITING",
      "last_update": "2025-11-19",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06993844",
      "title": "Phase 1/2 Study of ETX-636 in Participants With Advanced Solid Tumors",
      "status": "RECRUITING",
      "last_update": "2026-06-23",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07109726",
      "title": "A Phase 1/2 Trial of TER-2013 in Patients With Solid Tumors Harboring AKT/PI3K/PTEN Pathway Alterations",
      "status": "RECRUITING",
      "last_update": "2026-08-21",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00002976",
      "title": "Estrogen Replacement Therapy in Treating Women With Early-Stage Endometrial Cancer",
      "status": "TERMINATED",
      "last_update": "2013-04-11",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00006903",
      "title": "Fulvestrant in Treating Patients With Recurrent, Persistent, or Metastatic Endometrial Cancer",
      "status": "UNKNOWN",
      "last_update": "2019-03-20",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00033358",
      "title": "Hormone Therapy in Preventing Endometrial Cancer in Patients With a Genetic Risk For Hereditary Nonpolyposis Colon Cancer",
      "status": "COMPLETED",
      "last_update": "2013-05-03",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00334295",
      "title": "Fulvestrant for the Treatment of Recurrent or Metastatic Endometrial Carcinoma.",
      "status": "COMPLETED",
      "last_update": "2012-07-31",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00919919",
      "title": "Efficacy and Tolerability Study of Progesterone Vaginal Tablets (Endometrin\u00ae) in Menopausal Women Treated by Estrogen",
      "status": "UNKNOWN",
      "last_update": "2009-06-12",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02872818",
      "title": "Apoptotic Signaling Pathways in Rats With Endometrial Hyperplasia",
      "status": "COMPLETED",
      "last_update": "2016-08-23",
      "phase": "PHASE4",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03643510",
      "title": "Evaluating Cancer Response to Treatment With Abemaciclib and Fulvestrant in Women With Recurrent Endometrial Cancer",
      "status": "COMPLETED",
      "last_update": "2026-03-16",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03926936",
      "title": "FUlvestrant in Gynecological Cancers That Are Potentially Hormone Sensitive: the FUCHSia Study",
      "status": "COMPLETED",
      "last_update": "2024-05-28",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04002635",
      "title": "Letrozole for Frozen Embryo Transfer (FET) in Patients With Polycystic Ovary Syndrome (PCOS)",
      "status": "WITHDRAWN",
      "last_update": "2021-01-08",
      "phase": "PHASE4",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04498520",
      "title": "Abexinostat, Palbociclib, and Fulvestrant for the Treatment of Breast or Gynecologic Cancer",
      "status": "WITHDRAWN",
      "last_update": "2021-05-18",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05082025",
      "title": "Phase 2 Study of PI3K Inhibitor Copanlisib in Combination With Fulvestrant in Selected ER+ and/or PR+ Cancers With PI3K (PIK3CA, PIK3R1) and/or PTEN Alterations",
      "status": "TERMINATED",
      "last_update": "2026-01-09",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05154487",
      "title": "A Study of Alpelisib and Fulvestrant to Treat Endometrial Cancer",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-07-30",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05189873",
      "title": "GnRH Agonist Plus Hormone Replacement Therapy vs Hormone Replacement Therapy on IVF Outcomes",
      "status": "COMPLETED",
      "last_update": "2022-01-13",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05238922",
      "title": "Study of INCB123667 in Subjects With Advanced Solid Tumors",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-07-21",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05252416",
      "title": "(VELA) Study of BLU-222 in Advanced Solid Tumors",
      "status": "TERMINATED",
      "last_update": "2025-11-28",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05905341",
      "title": "Study of PF-07224826, as a Single Agent or in Combination With Endocrine Therapy in Participants With Breast Cancer and Other Advanced Solid Tumors.",
      "status": "WITHDRAWN",
      "last_update": "2023-11-08",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06257264",
      "title": "A Study to Examine the Safety of Different Doses of BG-68501 Given to Participants With Advanced-Stage Tumors",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-06-18",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07038369",
      "title": "A Phase 1 Study of ATV-1601 in Patients With Advanced Cancer That Have AKT1 E17K Mutations",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-08-07",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07811232",
      "title": "A Study of AL58805 in Advanced, Metastatic GYN, STS or Breast Cancers",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2026-09-10",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     }
    ]
   },
   "ESTROGENS, CONJUGATED": {
    "n": 1,
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    "trials": [
     {
      "nct": "NCT00002976",
      "title": "Estrogen Replacement Therapy in Treating Women With Early-Stage Endometrial Cancer",
      "status": "TERMINATED",
      "last_update": "2013-04-11",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     }
    ]
   },
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    "trials": [
     {
      "nct": "NCT00033358",
      "title": "Hormone Therapy in Preventing Endometrial Cancer in Patients With a Genetic Risk For Hereditary Nonpolyposis Colon Cancer",
      "status": "COMPLETED",
      "last_update": "2013-05-03",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     }
    ]
   },
   "ESTROPIPATE": {
    "n": 1,
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     {
      "nct": "NCT00033358",
      "title": "Hormone Therapy in Preventing Endometrial Cancer in Patients With a Genetic Risk For Hereditary Nonpolyposis Colon Cancer",
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      "last_update": "2013-05-03",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     }
    ]
   },
   "ETHINYL ESTRADIOL": {
    "n": 2,
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    "n_active": 1,
    "n_withdrawn": 0,
    "trials": [
     {
      "nct": "NCT05316935",
      "title": "GnRHa + Letrozole in Non-obese Progestin-insensitive Endometrial Cancer and Atypical Hyperplasia Patients",
      "status": "RECRUITING",
      "last_update": "2026-09-10",
      "phase": "PHASE2/PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00033358",
      "title": "Hormone Therapy in Preventing Endometrial Cancer in Patients With a Genetic Risk For Hereditary Nonpolyposis Colon Cancer",
      "status": "COMPLETED",
      "last_update": "2013-05-03",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     }
    ]
   },
   "FLUDARABINE": {
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    "n_withdrawn": 0,
    "trials": [
     {
      "nct": "NCT01174121",
      "title": "Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic Cancer",
      "status": "RECRUITING",
      "last_update": "2026-09-01",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06481592",
      "title": "A Study of Lifileucel (Tumor-infiltrating Lymphocytes) in Adults With Advanced Endometrial Cancer.",
      "status": "RECRUITING",
      "last_update": "2025-10-30",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07593820",
      "title": "A Phase I Interventional Open-label, Non-randomized Dose-escalation Trial to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, Immunogenicity, and Preliminary Anti-tumor Activity of Autologous p95HER2.CAR-TECH2Me T Cells in Patients With Selected Advanced Cancers.",
      "status": "RECRUITING",
      "last_update": "2026-05-22",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04319757",
      "title": "ACE1702 in Subjects With Advanced or Metastatic HER2-expressing Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2024-12-05",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05069935",
      "title": "FT538 in Combination With Monoclonal Antibodies in Advanced Solid Tumors",
      "status": "TERMINATED",
      "last_update": "2023-09-21",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     }
    ]
   },
   "FULVESTRANT": {
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    "n_observational": 0,
    "n_active": 11,
    "n_withdrawn": 2,
    "trials": [
     {
      "nct": "NCT05564377",
      "title": "Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial",
      "status": "RECRUITING",
      "last_update": "2026-09-11",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05768139",
      "title": "First-in-Human Study of Tersolisib (STX-478) as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors",
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     {
      "nct": "NCT05867251",
      "title": "Study of AVZO-021 in Patients With Advanced Solid Tumors",
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      "title": "Phase 1/2 Study of ETX-636 in Participants With Advanced Solid Tumors",
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      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT07109726",
      "title": "A Phase 1/2 Trial of TER-2013 in Patients With Solid Tumors Harboring AKT/PI3K/PTEN Pathway Alterations",
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      "last_update": "2026-08-21",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT07114601",
      "title": "A Study of LY4257496 in Participants With Cancer (OMNIRAY)",
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      "last_update": "2026-09-04",
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      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00006903",
      "title": "Fulvestrant in Treating Patients With Recurrent, Persistent, or Metastatic Endometrial Cancer",
      "status": "UNKNOWN",
      "last_update": "2019-03-20",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00334295",
      "title": "Fulvestrant for the Treatment of Recurrent or Metastatic Endometrial Carcinoma.",
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     {
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      "title": "Safety, Tolerability & Potential Anti-cancer Activity of Increasing Doses of AZD5363 in Different Treatment Schedules",
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      "last_update": "2025-06-29",
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     {
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      "title": "Evaluating Cancer Response to Treatment With Abemaciclib and Fulvestrant in Women With Recurrent Endometrial Cancer",
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     {
      "nct": "NCT03926936",
      "title": "FUlvestrant in Gynecological Cancers That Are Potentially Hormone Sensitive: the FUCHSia Study",
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     {
      "nct": "NCT04498520",
      "title": "Abexinostat, Palbociclib, and Fulvestrant for the Treatment of Breast or Gynecologic Cancer",
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     {
      "nct": "NCT05082025",
      "title": "Phase 2 Study of PI3K Inhibitor Copanlisib in Combination With Fulvestrant in Selected ER+ and/or PR+ Cancers With PI3K (PIK3CA, PIK3R1) and/or PTEN Alterations",
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     {
      "nct": "NCT05154487",
      "title": "A Study of Alpelisib and Fulvestrant to Treat Endometrial Cancer",
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      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT05238922",
      "title": "Study of INCB123667 in Subjects With Advanced Solid Tumors",
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      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT05252416",
      "title": "(VELA) Study of BLU-222 in Advanced Solid Tumors",
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      "last_update": "2025-11-28",
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     {
      "nct": "NCT05905341",
      "title": "Study of PF-07224826, as a Single Agent or in Combination With Endocrine Therapy in Participants With Breast Cancer and Other Advanced Solid Tumors.",
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      "last_update": "2023-11-08",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06257264",
      "title": "A Study to Examine the Safety of Different Doses of BG-68501 Given to Participants With Advanced-Stage Tumors",
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      "last_update": "2026-06-18",
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     {
      "nct": "NCT07038369",
      "title": "A Phase 1 Study of ATV-1601 in Patients With Advanced Cancer That Have AKT1 E17K Mutations",
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      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT07811232",
      "title": "A Study of AL58805 in Advanced, Metastatic GYN, STS or Breast Cancers",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2026-09-10",
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      "nct": "NCT03675893",
      "title": "RESOLVE: Abemaciclib + Letrozole +/- Metformin or Gedatolisib in Endometrial Cancer",
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      "last_update": "2026-06-22",
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     {
      "nct": "NCT01420081",
      "title": "A Study Of Two Dual PI3K/mTOR Inhibitors, PF-04691502 And PF-05212384 In Patients With Recurrent Endometrial Cancer",
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     {
      "nct": "NCT02069158",
      "title": "Dose Finding Study Of PF-05212384 With Paclitaxel And Carboplatin In Patients With Advanced Solid Tumor",
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      "last_update": "2019-05-21",
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     {
      "nct": "NCT03065062",
      "title": "Study of the CDK4/6 Inhibitor Palbociclib (PD-0332991) in Combination With the PI3K/mTOR Inhibitor Gedatolisib (PF-05212384) for Patients With Advanced Squamous Cell Lung, Pancreatic, Head & Neck and Other Solid Tumors",
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      "title": "Recurrent Ovarian CarcinoSarcoma Anti-pd-1 Niraparib",
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     {
      "nct": "NCT04657068",
      "title": "A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors",
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     {
      "nct": "NCT05548296",
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     {
      "nct": "NCT06023862",
      "title": "A Three-arm Randomized Phase II Study of Dostarlimab Alone or With Bevacizumab Versus Nonplatinum Chemotherapy in Recurrent Gynecological Clear Cell Carcinoma: DOVE (APGOT-OV7/ ENGOT-ov80 Study)",
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     {
      "nct": "NCT06333314",
      "title": "Dostarlimab for Locally Advanced or Metastatic Cancer (Non-colorectal/Non-endometrial) With Tumor dMMR/MSI",
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      "last_update": "2025-12-02",
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     {
      "nct": "NCT06840886",
      "title": "A Study of PHST001 in Advanced Solid Tumors",
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      "last_update": "2026-08-12",
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      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00004082",
      "title": "Combination Chemotherapy in Treating Patients With Previously Untreated, Newly Diagnosed Epithelial Tumors",
      "status": "COMPLETED",
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     {
      "nct": "NCT00258362",
      "title": "Carboplatin, Docetaxel, and Radiation Therapy in Treating Patients With Stage III/IV, or Recurrent Endometrial Cancer",
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      "last_update": "2017-12-28",
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     {
      "nct": "NCT00388154",
      "title": "Gemcitabine and Cisplatin for Advanced or Recurrent Endometrial Cancer",
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      "last_update": "2014-11-13",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00610740",
      "title": "CerviPrep for Applying Topical Gemcitabine to the Cervix in Treating Patients With Primary Endometrial, Cervical, or Ovarian Epithelial Cancer",
      "status": "COMPLETED",
      "last_update": "2017-12-28",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00820898",
      "title": "Gemcitabine in Treating Patients With Recurrent or Persistent Endometrial Cancer",
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      "last_update": "2017-12-29",
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     {
      "nct": "NCT01652794",
      "title": "Carboplatin, Gemcitabine Hydrochloride, and Stereotactic Body Radiation Therapy in Gynecological Cancer",
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      "last_update": "2015-08-04",
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      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02393248",
      "title": "Open-Label, Dose-Escalation Study of Pemigatinib in Subjects With Advanced Malignancies - (FIGHT-101)",
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     {
      "nct": "NCT02632448",
      "title": "A Study of LY2880070 in Participants With Advanced or Metastatic Cancer",
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     {
      "nct": "NCT02996825",
      "title": "Mirvetuximab Soravtansine and Gemcitabine Hydrochloride in Treating Patients With FRalpha-Positive Recurrent Ovarian, Primary Peritoneal, Fallopian Tube, Endometrial, or Triple Negative Breast Cancer",
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     {
      "nct": "NCT03076372",
      "title": "A Study Evaluating MM-310 in Patients With Solid Tumors",
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     {
      "nct": "NCT03314935",
      "title": "A Phase 1/2 Study of INCB001158 in Combination With Chemotherapy in Subjects With Solid Tumors",
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     {
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      "title": "Testing the Addition of an Anti-cancer Drug, BAY 1895344, to the Usual Chemotherapy Treatment (Cisplatin, or Cisplatin and Gemcitabine) for Advanced Solid Tumors With Emphasis on Urothelial Cancer",
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     {
      "nct": "NCT05007106",
      "title": "MK-7684A With or Without Other Anticancer Therapies in Participants With Selected Solid Tumors (MK-7684A-005) (KEYVIBE-005)",
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      "last_update": "2025-08-14",
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     {
      "nct": "NCT05481645",
      "title": "Efficacy and Safety of TQB2450 Injection Combined With Chemotherapy \u00b1 Anlotinib Hydrochloride Capsules for Advanced Endometrial Cancer or Sarcoma of Uterus.",
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     {
      "nct": "NCT06607185",
      "title": "A Study of the Pan-KRAS Inhibitor LY4066434 in Participants With KRAS Mutant Solid Tumors",
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      "last_update": "2026-07-20",
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     {
      "nct": "NCT05634499",
      "title": "A Study of Giredestrant in Participants With Grade 1 Endometrial Cancer",
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     {
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      "title": "First-in-Human Study of Tersolisib (STX-478) as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors",
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     {
      "nct": "NCT07522697",
      "title": "Inavolisib for PIK3CA Mutated Advanced Endometrial Cancer: MITO END-4",
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      "title": "Lapatinib in Treating Patients With Recurrent or Persistent Endometrial Cancer",
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     {
      "nct": "NCT01454479",
      "title": "A Phase I Study of Lapatinib (Tykerb) Plus Ixabepilone (Ixempra) as 2nd-line Treatment for Patients With HER-2 Overexpressed Recurrent or Persistent Endometrial Carcinoma or Carcinosarcoma",
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      "nct": "NCT00096447",
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      "nct": "NCT01454479",
      "title": "A Phase I Study of Lapatinib (Tykerb) Plus Ixabepilone (Ixempra) as 2nd-line Treatment for Patients With HER-2 Overexpressed Recurrent or Persistent Endometrial Carcinoma or Carcinosarcoma",
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      "nct": "NCT03463252",
      "title": "Value of LNG-IUS as Fertility-preserving Treatment of EAH and EC",
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      "last_update": "2021-09-13",
      "phase": "PHASE2/PHASE3",
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     {
      "nct": "NCT05903131",
      "title": "Uterine Preservation Via Lifestyle Transformation",
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      "last_update": "2026-01-20",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT05945407",
      "title": "Fertility-sparing Therapy for Patients With Stage IA Endometrial Cancer",
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      "last_update": "2023-07-14",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06102863",
      "title": "Progesterone Therapeutic Regimen Plus Statins in Young Women With Early Endometrial Carcinoma and Atypical Endometrial Hyperplasia",
      "status": "RECRUITING",
      "last_update": "2025-04-29",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06468215",
      "title": "Fertility Sparing Therapy for Patients With Stage IA G2 Endometrial Cancer",
      "status": "RECRUITING",
      "last_update": "2026-08-21",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07107334",
      "title": "A Study to Estimate Early Clinical Efficacy Signals of GLP-1 Agonist Administration in Conjunction With Levonorgestrel Intrauterine Device in Obese Patients With Endometrioid Intraepithelial Neoplasia",
      "status": "RECRUITING",
      "last_update": "2026-06-08",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00033358",
      "title": "Hormone Therapy in Preventing Endometrial Cancer in Patients With a Genetic Risk For Hereditary Nonpolyposis Colon Cancer",
      "status": "COMPLETED",
      "last_update": "2013-05-03",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00566644",
      "title": "Intrauterine Levonorgestrel and Observation or Observation Alone in Preventing Atypical Endometrial Hyperplasia and Endometrial Cancer in Women With Hereditary Non-Polyposis Colorectal Cancer or Lynch Syndrome",
      "status": "TERMINATED",
      "last_update": "2013-07-10",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00788671",
      "title": "Levonorgestrel-Releasing Intrauterine System in Treating Patients With Complex Atypical Hyperplasia or Grade I Endometrial Cancer",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-08-15",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01234818",
      "title": "Management of Endometrial Hyperplasia With a LNG-IUS: Multicenter Study: KGOG2006",
      "status": "UNKNOWN",
      "last_update": "2012-11-12",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01594879",
      "title": "Treatment With Medroxyprogesterone Acetate Plus LNG-IUS in Young Women With Early Stage Endometrial Cancer",
      "status": "UNKNOWN",
      "last_update": "2012-05-09",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01686126",
      "title": "Improving the Treatment for Women With Early Stage Cancer of the Uterus",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2024-08-28",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01943058",
      "title": "Megestrol Acetate or Levonorgestrel-Releasing Intrauterine System in Treating Patients With Atypical Endometrial Hyperplasia or Endometrial Cancer",
      "status": "WITHDRAWN",
      "last_update": "2014-09-10",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02035787",
      "title": "Metformin With the Levonorgestrel-Releasing Intrauterine Device for the Treatment of Complex Atypical Hyperplasia (CAH) and Endometrial Cancer (EC) in Non-surgical Patients",
      "status": "COMPLETED",
      "last_update": "2024-12-18",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02397083",
      "title": "Levonorgestrel-Releasing Intrauterine System With or Without Everolimus in Treating Patients With Atypical Hyperplasia or Stage IA Grade 1 Endometrial Cancer",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-09-10",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02990728",
      "title": "Mirena\u00ae \u00b1 Metformin as Fertility-preserving Treatment for Young Asian Women With Early Endometrial Cancer",
      "status": "UNKNOWN",
      "last_update": "2016-12-13",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03241914",
      "title": "Megestrol Acetate Plus LNG-IUS in Young Women With Early Endometrial Cancer",
      "status": "COMPLETED",
      "last_update": "2020-11-20",
      "phase": "PHASE2/PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04792749",
      "title": "Clinical Effects of Metformin on Fertility-sparing Treatment for Early Endometrial Cancer",
      "status": "UNKNOWN",
      "last_update": "2023-04-13",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06073184",
      "title": "Weight-loss Drug for Fertility-Sparing Treatment of Atypical Hyperplasia and Low-grade Cancer of the Endometrium",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2025-06-10",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06942377",
      "title": "Calcium Channel Blocker Amlodipine for Endometrial Cancer Therapy",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2025-07-08",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07462663",
      "title": "SHAPE-ENDO: Pilot Randomized Trial of Multimodal Pre-Surgical Optimization Versus Standard Surgery in Patients With Obesity and Early-Stage Endometrial Cancer",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2026-06-10",
      "phase": "PHASE4",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07781150",
      "title": "Mazdutide Plus LNG-IUS for Fertility-Sparing Treatment of AEH or Early Endometrial Cancer",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2026-08-24",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07812636",
      "title": "Tirzepatide and Levonorgestrel IUD Therapy for EIN and Early-Stage Endometrial Cancer",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2026-09-10",
      "phase": "EARLY_PHASE1",
      "study_type": "INTERVENTIONAL"
     }
    ]
   },
   "MEDROXYPROGESTERONE": {
    "n": 31,
    "n_observational": 0,
    "n_active": 13,
    "n_withdrawn": 1,
    "trials": [
     {
      "nct": "NCT03463252",
      "title": "Value of LNG-IUS as Fertility-preserving Treatment of EAH and EC",
      "status": "RECRUITING",
      "last_update": "2021-09-13",
      "phase": "PHASE2/PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05247268",
      "title": "Gonadotropin-releasing Hormone Agonist (GnRHa) Plus Letrozole In Young Women With Early Endometrial Cancer",
      "status": "RECRUITING",
      "last_update": "2026-06-04",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05255653",
      "title": "Refining Adjuvant Treatment IN Endometrial Cancer Based On Molecular Features",
      "status": "RECRUITING",
      "last_update": "2026-05-15",
      "phase": "PHASE2/PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05945407",
      "title": "Fertility-sparing Therapy for Patients With Stage IA Endometrial Cancer",
      "status": "RECRUITING",
      "last_update": "2023-07-14",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06102863",
      "title": "Progesterone Therapeutic Regimen Plus Statins in Young Women With Early Endometrial Carcinoma and Atypical Endometrial Hyperplasia",
      "status": "RECRUITING",
      "last_update": "2025-04-29",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06468215",
      "title": "Fertility Sparing Therapy for Patients With Stage IA G2 Endometrial Cancer",
      "status": "RECRUITING",
      "last_update": "2026-08-21",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06549855",
      "title": "PD-1 Inhibitor Combined With Progesterone Treatment in FST for Patients With MMRd Endometrial Cancer",
      "status": "RECRUITING",
      "last_update": "2026-08-10",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06914297",
      "title": "TQB2450 Plus Progestin for Fertility-sparing Treatment in MMRd EC",
      "status": "RECRUITING",
      "last_update": "2026-06-04",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07319429",
      "title": "Refining Fertility-sparing Treatment in Endometrial Carcinoma Based on Molecular Classification",
      "status": "RECRUITING",
      "last_update": "2026-03-13",
      "phase": "PHASE2/PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07377734",
      "title": "Intrauterine Injection of Type III Collage in FST of EC/AEH",
      "status": "RECRUITING",
      "last_update": "2026-03-30",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00002920",
      "title": "S9630, Medroxyprogesterone in Treating Women With Breast Cancer",
      "status": "COMPLETED",
      "last_update": "2012-10-31",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00003179",
      "title": "Surgery Plus Medroxyprogesterone in Preventing Endometrial Cancer",
      "status": "TERMINATED",
      "last_update": "2013-06-10",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00033358",
      "title": "Hormone Therapy in Preventing Endometrial Cancer in Patients With a Genetic Risk For Hereditary Nonpolyposis Colon Cancer",
      "status": "COMPLETED",
      "last_update": "2013-05-03",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00064025",
      "title": "Medroxyprogesterone in Treating Patients With Endometrioid Adenocarcinoma of the Uterine Corpus",
      "status": "COMPLETED",
      "last_update": "2016-04-11",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00739830",
      "title": "Clinical Trial of Ridaforolimus Compared to Progestin or Chemotherapy for Advanced Endometrial Carcinoma (MK-8669-007 AM6)",
      "status": "COMPLETED",
      "last_update": "2015-07-01",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01594879",
      "title": "Treatment With Medroxyprogesterone Acetate Plus LNG-IUS in Young Women With Early Stage Endometrial Cancer",
      "status": "UNKNOWN",
      "last_update": "2012-05-09",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01718444",
      "title": "Progestin-induced Endometrial Shedding in PCOS (The PIES in PCOS Study)",
      "status": "TERMINATED",
      "last_update": "2020-09-29",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01966575",
      "title": "Effect of Progestin-Induced Withdrawal Bleed on Ovulation Induction Cycles With Clomiphene Citrate",
      "status": "WITHDRAWN",
      "last_update": "2014-11-06",
      "phase": "PHASE4",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02064725",
      "title": "Virexxa (Sodium Cridanimod) w/Progestin Therapy in Pts w/Progesterone Receptor Neg Recurrent/Persistent Endometrial CA",
      "status": "UNKNOWN",
      "last_update": "2017-01-24",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02228681",
      "title": "Everolimus and Letrozole or Hormonal Therapy to Treat Endometrial Cancer",
      "status": "COMPLETED",
      "last_update": "2024-09-19",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02872818",
      "title": "Apoptotic Signaling Pathways in Rats With Endometrial Hyperplasia",
      "status": "COMPLETED",
      "last_update": "2016-08-23",
      "phase": "PHASE4",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02990728",
      "title": "Mirena\u00ae \u00b1 Metformin as Fertility-preserving Treatment for Young Asian Women With Early Endometrial Cancer",
      "status": "UNKNOWN",
      "last_update": "2016-12-13",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03018249",
      "title": "Medroxyprogesterone Acetate With or Without Entinostat Before Surgery in Treating Patients With Endometrioid Endometrial Cancer",
      "status": "COMPLETED",
      "last_update": "2021-11-16",
      "phase": "EARLY_PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03538704",
      "title": "Effect of Fertility-sparing Therapy of Early Endometrial Cancer",
      "status": "UNKNOWN",
      "last_update": "2018-05-29",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03567655",
      "title": "Fertility-sparing Management Using High-dose Oral Progestin in Young Women With Endometrial Cancer",
      "status": "UNKNOWN",
      "last_update": "2018-06-26",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04792749",
      "title": "Clinical Effects of Metformin on Fertility-sparing Treatment for Early Endometrial Cancer",
      "status": "UNKNOWN",
      "last_update": "2023-04-13",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05651282",
      "title": "Risk Evaluation and Screening to Tailor Prevention and Reduce the Incidence of Endometrial Cancer",
      "status": "COMPLETED",
      "last_update": "2026-04-13",
      "phase": "PHASE4",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05675787",
      "title": "Medroxyprogesterone Acetate Plus Atorvastatin in Young Women With Early Endometrial Carcinoma and Atypical Endometrial Hyperplasia",
      "status": "UNKNOWN",
      "last_update": "2024-07-11",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06942377",
      "title": "Calcium Channel Blocker Amlodipine for Endometrial Cancer Therapy",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2025-07-08",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07462663",
      "title": "SHAPE-ENDO: Pilot Randomized Trial of Multimodal Pre-Surgical Optimization Versus Standard Surgery in Patients With Obesity and Early-Stage Endometrial Cancer",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2026-06-10",
      "phase": "PHASE4",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07714070",
      "title": "Orlistat Plus Progestin for Fertility-Sparing Treatment of Endometrial Cancer or Atypical Hyperplasia",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2026-07-20",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     }
    ]
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   "MEGESTROL": {
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     {
      "nct": "NCT05247268",
      "title": "Gonadotropin-releasing Hormone Agonist (GnRHa) Plus Letrozole In Young Women With Early Endometrial Cancer",
      "status": "RECRUITING",
      "last_update": "2026-06-04",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05255653",
      "title": "Refining Adjuvant Treatment IN Endometrial Cancer Based On Molecular Features",
      "status": "RECRUITING",
      "last_update": "2026-05-15",
      "phase": "PHASE2/PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05945407",
      "title": "Fertility-sparing Therapy for Patients With Stage IA Endometrial Cancer",
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      "last_update": "2023-07-14",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06417736",
      "title": "Prospective Study for Endometrial Carcinoma and Hyperplasia in Childbearing-age Women",
      "status": "RECRUITING",
      "last_update": "2024-05-16",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06549855",
      "title": "PD-1 Inhibitor Combined With Progesterone Treatment in FST for Patients With MMRd Endometrial Cancer",
      "status": "RECRUITING",
      "last_update": "2026-08-10",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06914297",
      "title": "TQB2450 Plus Progestin for Fertility-sparing Treatment in MMRd EC",
      "status": "RECRUITING",
      "last_update": "2026-06-04",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07319429",
      "title": "Refining Fertility-sparing Treatment in Endometrial Carcinoma Based on Molecular Classification",
      "status": "RECRUITING",
      "last_update": "2026-03-13",
      "phase": "PHASE2/PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07377734",
      "title": "Intrauterine Injection of Type III Collage in FST of EC/AEH",
      "status": "RECRUITING",
      "last_update": "2026-03-30",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07436793",
      "title": "Progestins for the Treatment of Endometrial Cancer or Precancers of the Uterus Before Surgery, The Pro-Window Trial",
      "status": "RECRUITING",
      "last_update": "2026-07-02",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00002465",
      "title": "High-Dose Megestrol in Treating Patients With Metastatic Breast Cancer, Endometrial Cancer, or Mesothelioma",
      "status": "UNKNOWN",
      "last_update": "2013-11-06",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00016341",
      "title": "Combination Chemotherapy Compared With Hormone Therapy in Treating Patients With Recurrent, Stage III, or Stage IV Endometrial Cancer",
      "status": "TERMINATED",
      "last_update": "2013-04-11",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00483327",
      "title": "Management of Atypical Endometrial Hyperplasia and Endometrial Carcinoma Using Megestrol Acetate",
      "status": "COMPLETED",
      "last_update": "2018-04-04",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00503581",
      "title": "Megestrol in Treating Patients With Endometrial Neoplasia or Endometrial Hyperplasia",
      "status": "TERMINATED",
      "last_update": "2020-11-03",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00584857",
      "title": "A Phase II Study of Therapy With Paclitaxel, Carboplatin and Megesterol Acetate for the Management of Uterine Cancer",
      "status": "COMPLETED",
      "last_update": "2017-01-27",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00729586",
      "title": "Temsirolimus With or Without Megestrol Acetate and Tamoxifen Citrate in Treating Patients With Advanced, Persistent, or Recurrent Endometrial Cancer",
      "status": "COMPLETED",
      "last_update": "2019-07-23",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00739830",
      "title": "Clinical Trial of Ridaforolimus Compared to Progestin or Chemotherapy for Advanced Endometrial Carcinoma (MK-8669-007 AM6)",
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      "last_update": "2015-07-01",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00910091",
      "title": "The Study of Oral Steroid Sulphatase Inhibitor BN83495 Versus Megestrol Acetate (MA) in Women With Advanced or Recurrent Endometrial Cancer",
      "status": "COMPLETED",
      "last_update": "2019-01-30",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01943058",
      "title": "Megestrol Acetate or Levonorgestrel-Releasing Intrauterine System in Treating Patients With Atypical Endometrial Hyperplasia or Endometrial Cancer",
      "status": "WITHDRAWN",
      "last_update": "2014-09-10",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02064725",
      "title": "Virexxa (Sodium Cridanimod) w/Progestin Therapy in Pts w/Progesterone Receptor Neg Recurrent/Persistent Endometrial CA",
      "status": "UNKNOWN",
      "last_update": "2017-01-24",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02990728",
      "title": "Mirena\u00ae \u00b1 Metformin as Fertility-preserving Treatment for Young Asian Women With Early Endometrial Cancer",
      "status": "UNKNOWN",
      "last_update": "2016-12-13",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03077698",
      "title": "An Endometrial Cancer Study for Women With Recurrent or Persistent Endometrial Cancer",
      "status": "TERMINATED",
      "last_update": "2022-06-07",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03241914",
      "title": "Megestrol Acetate Plus LNG-IUS in Young Women With Early Endometrial Cancer",
      "status": "COMPLETED",
      "last_update": "2020-11-20",
      "phase": "PHASE2/PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03671811",
      "title": "Megestrol Acetate With or Without Pterostilbene in Treating Patients With Endometrial Cancer Undergoing Hysterectomy",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-06-03",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04046185",
      "title": "Programmed Death-1(PD-1) Inhibitor Combined With Progesterone Treatment in Endometrial Cancer",
      "status": "UNKNOWN",
      "last_update": "2019-08-06",
      "phase": "EARLY_PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04491643",
      "title": "Megestrol Acetate Plus Rosuvastatin in Young Women With Early Endometrial Carcinoma",
      "status": "COMPLETED",
      "last_update": "2025-08-11",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04576104",
      "title": "Megestrol Acetate Compared With Megestrol Acetate and Metformin to Prevent Endometrial Cancer",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-01-21",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05316467",
      "title": "Weight Management Plus Megestrol Acetate in Early-stage Endometrioid Carcinoma",
      "status": "TERMINATED",
      "last_update": "2026-06-04",
      "phase": "PHASE2/PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05332483",
      "title": "Study of Megestrol Acetate in Grade 2 Endometrioid Endometrial Cancer",
      "status": "TERMINATED",
      "last_update": "2023-11-03",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05538897",
      "title": "Testing the Addition of the AKT Inhibitor, Ipatasertib, to Treatment With the Hormonal Agent Megestrol Acetate for Recurrent or Metastatic Endometrial Cancers",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-07-27",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07462663",
      "title": "SHAPE-ENDO: Pilot Randomized Trial of Multimodal Pre-Surgical Optimization Versus Standard Surgery in Patients With Obesity and Early-Stage Endometrial Cancer",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2026-06-10",
      "phase": "PHASE4",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07714070",
      "title": "Orlistat Plus Progestin for Fertility-Sparing Treatment of Endometrial Cancer or Atypical Hyperplasia",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2026-07-20",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     }
    ]
   },
   "MIFEPRISTONE": {
    "n": 1,
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    "n_withdrawn": 0,
    "trials": [
     {
      "nct": "NCT00505739",
      "title": "Mifepristone for Patients With Endometrial Cancer and LGESS",
      "status": "COMPLETED",
      "last_update": "2012-07-30",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     }
    ]
   },
   "NAVTEMADLIN": {
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    "trials": [
     {
      "nct": "NCT05797831",
      "title": "Study of Navtemadlin as Maintenance Therapy in TP53WT Advanced or Recurrent Endometrial Cancer",
      "status": "RECRUITING",
      "last_update": "2024-05-02",
      "phase": "PHASE2/PHASE3",
      "study_type": "INTERVENTIONAL"
     }
    ]
   },
   "NERATINIB": {
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    "trials": [
     {
      "nct": "NCT05564377",
      "title": "Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial",
      "status": "RECRUITING",
      "last_update": "2026-09-11",
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     {
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      "title": "A Study Of Two Dual PI3K/mTOR Inhibitors, PF-04691502 And PF-05212384 In Patients With Recurrent Endometrial Cancer",
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     {
      "nct": "NCT01013324",
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     {
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      "title": "First-in-Human Study of Tersolisib (STX-478) as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors",
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     {
      "nct": "NCT07109726",
      "title": "A Phase 1/2 Trial of TER-2013 in Patients With Solid Tumors Harboring AKT/PI3K/PTEN Pathway Alterations",
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      "phase": "PHASE1/PHASE2",
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     {
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     {
      "nct": "NCT00006903",
      "title": "Fulvestrant in Treating Patients With Recurrent, Persistent, or Metastatic Endometrial Cancer",
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     {
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      "title": "Fulvestrant for the Treatment of Recurrent or Metastatic Endometrial Carcinoma.",
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     },
     {
      "nct": "NCT00919919",
      "title": "Efficacy and Tolerability Study of Progesterone Vaginal Tablets (Endometrin\u00ae) in Menopausal Women Treated by Estrogen",
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      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT02872818",
      "title": "Apoptotic Signaling Pathways in Rats With Endometrial Hyperplasia",
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      "last_update": "2016-08-23",
      "phase": "PHASE4",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03643510",
      "title": "Evaluating Cancer Response to Treatment With Abemaciclib and Fulvestrant in Women With Recurrent Endometrial Cancer",
      "status": "COMPLETED",
      "last_update": "2026-03-16",
      "phase": "PHASE2",
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     },
     {
      "nct": "NCT03926936",
      "title": "FUlvestrant in Gynecological Cancers That Are Potentially Hormone Sensitive: the FUCHSia Study",
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      "phase": "PHASE2",
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     },
     {
      "nct": "NCT04002635",
      "title": "Letrozole for Frozen Embryo Transfer (FET) in Patients With Polycystic Ovary Syndrome (PCOS)",
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      "phase": "PHASE4",
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     {
      "nct": "NCT04498520",
      "title": "Abexinostat, Palbociclib, and Fulvestrant for the Treatment of Breast or Gynecologic Cancer",
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      "last_update": "2021-05-18",
      "phase": "PHASE1",
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     },
     {
      "nct": "NCT05082025",
      "title": "Phase 2 Study of PI3K Inhibitor Copanlisib in Combination With Fulvestrant in Selected ER+ and/or PR+ Cancers With PI3K (PIK3CA, PIK3R1) and/or PTEN Alterations",
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      "phase": "PHASE2",
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     {
      "nct": "NCT05154487",
      "title": "A Study of Alpelisib and Fulvestrant to Treat Endometrial Cancer",
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      "last_update": "2026-07-30",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT05189873",
      "title": "GnRH Agonist Plus Hormone Replacement Therapy vs Hormone Replacement Therapy on IVF Outcomes",
      "status": "COMPLETED",
      "last_update": "2022-01-13",
      "phase": "PHASE3",
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     },
     {
      "nct": "NCT05238922",
      "title": "Study of INCB123667 in Subjects With Advanced Solid Tumors",
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      "last_update": "2026-07-21",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT05252416",
      "title": "(VELA) Study of BLU-222 in Advanced Solid Tumors",
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      "phase": "PHASE1",
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     },
     {
      "nct": "NCT05905341",
      "title": "Study of PF-07224826, as a Single Agent or in Combination With Endocrine Therapy in Participants With Breast Cancer and Other Advanced Solid Tumors.",
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      "last_update": "2023-11-08",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06257264",
      "title": "A Study to Examine the Safety of Different Doses of BG-68501 Given to Participants With Advanced-Stage Tumors",
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      "last_update": "2026-06-18",
      "phase": "PHASE1",
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     {
      "nct": "NCT07038369",
      "title": "A Phase 1 Study of ATV-1601 in Patients With Advanced Cancer That Have AKT1 E17K Mutations",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-08-07",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT07811232",
      "title": "A Study of AL58805 in Advanced, Metastatic GYN, STS or Breast Cancers",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2026-09-10",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT03463252",
      "title": "Value of LNG-IUS as Fertility-preserving Treatment of EAH and EC",
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      "last_update": "2021-09-13",
      "phase": "PHASE2/PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04362046",
      "title": "Fertility Sparing Management of EndomeTrial Cancer and Hyperplasia",
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      "last_update": "2021-10-20",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05247268",
      "title": "Gonadotropin-releasing Hormone Agonist (GnRHa) Plus Letrozole In Young Women With Early Endometrial Cancer",
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      "last_update": "2026-06-04",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05255653",
      "title": "Refining Adjuvant Treatment IN Endometrial Cancer Based On Molecular Features",
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      "last_update": "2026-05-15",
      "phase": "PHASE2/PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05945407",
      "title": "Fertility-sparing Therapy for Patients With Stage IA Endometrial Cancer",
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      "last_update": "2023-07-14",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06102863",
      "title": "Progesterone Therapeutic Regimen Plus Statins in Young Women With Early Endometrial Carcinoma and Atypical Endometrial Hyperplasia",
      "status": "RECRUITING",
      "last_update": "2025-04-29",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06468215",
      "title": "Fertility Sparing Therapy for Patients With Stage IA G2 Endometrial Cancer",
      "status": "RECRUITING",
      "last_update": "2026-08-21",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06549855",
      "title": "PD-1 Inhibitor Combined With Progesterone Treatment in FST for Patients With MMRd Endometrial Cancer",
      "status": "RECRUITING",
      "last_update": "2026-08-10",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07319429",
      "title": "Refining Fertility-sparing Treatment in Endometrial Carcinoma Based on Molecular Classification",
      "status": "RECRUITING",
      "last_update": "2026-03-13",
      "phase": "PHASE2/PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07436793",
      "title": "Progestins for the Treatment of Endometrial Cancer or Precancers of the Uterus Before Surgery, The Pro-Window Trial",
      "status": "RECRUITING",
      "last_update": "2026-07-02",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00002920",
      "title": "S9630, Medroxyprogesterone in Treating Women With Breast Cancer",
      "status": "COMPLETED",
      "last_update": "2012-10-31",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00003179",
      "title": "Surgery Plus Medroxyprogesterone in Preventing Endometrial Cancer",
      "status": "TERMINATED",
      "last_update": "2013-06-10",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00033358",
      "title": "Hormone Therapy in Preventing Endometrial Cancer in Patients With a Genetic Risk For Hereditary Nonpolyposis Colon Cancer",
      "status": "COMPLETED",
      "last_update": "2013-05-03",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00064025",
      "title": "Medroxyprogesterone in Treating Patients With Endometrioid Adenocarcinoma of the Uterine Corpus",
      "status": "COMPLETED",
      "last_update": "2016-04-11",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00739830",
      "title": "Clinical Trial of Ridaforolimus Compared to Progestin or Chemotherapy for Advanced Endometrial Carcinoma (MK-8669-007 AM6)",
      "status": "COMPLETED",
      "last_update": "2015-07-01",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00919919",
      "title": "Efficacy and Tolerability Study of Progesterone Vaginal Tablets (Endometrin\u00ae) in Menopausal Women Treated by Estrogen",
      "status": "UNKNOWN",
      "last_update": "2009-06-12",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01718444",
      "title": "Progestin-induced Endometrial Shedding in PCOS (The PIES in PCOS Study)",
      "status": "TERMINATED",
      "last_update": "2020-09-29",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01966575",
      "title": "Effect of Progestin-Induced Withdrawal Bleed on Ovulation Induction Cycles With Clomiphene Citrate",
      "status": "WITHDRAWN",
      "last_update": "2014-11-06",
      "phase": "PHASE4",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02052128",
      "title": "Phase 1-2 Study of Onapristone in Patients With Progesterone Receptor Expressing Cancers",
      "status": "UNKNOWN",
      "last_update": "2015-06-24",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02064725",
      "title": "Virexxa (Sodium Cridanimod) w/Progestin Therapy in Pts w/Progesterone Receptor Neg Recurrent/Persistent Endometrial CA",
      "status": "UNKNOWN",
      "last_update": "2017-01-24",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02228681",
      "title": "Everolimus and Letrozole or Hormonal Therapy to Treat Endometrial Cancer",
      "status": "COMPLETED",
      "last_update": "2024-09-19",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02872818",
      "title": "Apoptotic Signaling Pathways in Rats With Endometrial Hyperplasia",
      "status": "COMPLETED",
      "last_update": "2016-08-23",
      "phase": "PHASE4",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03018249",
      "title": "Medroxyprogesterone Acetate With or Without Entinostat Before Surgery in Treating Patients With Endometrioid Endometrial Cancer",
      "status": "COMPLETED",
      "last_update": "2021-11-16",
      "phase": "EARLY_PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03077698",
      "title": "An Endometrial Cancer Study for Women With Recurrent or Persistent Endometrial Cancer",
      "status": "TERMINATED",
      "last_update": "2022-06-07",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03538704",
      "title": "Effect of Fertility-sparing Therapy of Early Endometrial Cancer",
      "status": "UNKNOWN",
      "last_update": "2018-05-29",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03567655",
      "title": "Fertility-sparing Management Using High-dose Oral Progestin in Young Women With Endometrial Cancer",
      "status": "UNKNOWN",
      "last_update": "2018-06-26",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03909152",
      "title": "A Study of Onapristone ER Alone Or In Combination With Anastrozole in Gynecologic Cancers That Respond to Progesterone",
      "status": "COMPLETED",
      "last_update": "2025-07-28",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04002635",
      "title": "Letrozole for Frozen Embryo Transfer (FET) in Patients With Polycystic Ovary Syndrome (PCOS)",
      "status": "WITHDRAWN",
      "last_update": "2021-01-08",
      "phase": "PHASE4",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04046185",
      "title": "Programmed Death-1(PD-1) Inhibitor Combined With Progesterone Treatment in Endometrial Cancer",
      "status": "UNKNOWN",
      "last_update": "2019-08-06",
      "phase": "EARLY_PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04485013",
      "title": "TTX-080 HLA-G Antagonist in Subjects With Advanced Cancers",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-09-11",
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      "title": "18-fluorofuranylnorprogesterone (FFNP) PET/MRI as a Potential Biomarker of Response to Progesterone Therapy",
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      "nct": "NCT05675787",
      "title": "Medroxyprogesterone Acetate Plus Atorvastatin in Young Women With Early Endometrial Carcinoma and Atypical Endometrial Hyperplasia",
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      "phase": "PHASE2",
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      "title": "Immunohistochemistry Role in Better Prognosis of Endometrial Carcinoma Patients",
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      "title": "Calcium Channel Blocker Amlodipine for Endometrial Cancer Therapy",
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      "title": "SHAPE-ENDO: Pilot Randomized Trial of Multimodal Pre-Surgical Optimization Versus Standard Surgery in Patients With Obesity and Early-Stage Endometrial Cancer",
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     {
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     {
      "nct": "NCT02725268",
      "title": "A Study of Sapanisertib, Combination of Sapanisertib With MLN1117, Paclitaxel and Combination of Sapanisertib With Paclitaxel in Women With Endometrial Cancer",
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      "title": "Combination Chemotherapy Compared With Hormone Therapy in Treating Patients With Recurrent, Stage III, or Stage IV Endometrial Cancer",
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     {
      "nct": "NCT00729586",
      "title": "Temsirolimus With or Without Megestrol Acetate and Tamoxifen Citrate in Treating Patients With Advanced, Persistent, or Recurrent Endometrial Cancer",
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      "last_update": "2019-07-23",
      "phase": "PHASE2",
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     {
      "nct": "NCT00814125",
      "title": "ATAC - Endometrial Sub-Protocol",
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     {
      "nct": "NCT01273168",
      "title": "Endoxifen in Adults With Hormone Receptor Positive Solid Tumors",
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      "last_update": "2025-12-23",
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     {
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     {
      "nct": "NCT07145827",
      "title": "Effect of Metformin on Endometrial Thickness in Postmenopausal Breast Cancer Patients Receiving Tamoxifen",
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     {
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      "title": "DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer",
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     {
      "nct": "NCT07022483",
      "title": "Study of Trastuzumab Deruxtecan Versus Standard of Care Chemotherapy for HER2-Expressing (IHC 3+/2+) Endometrial Cancer",
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     {
      "nct": "NCT07216105",
      "title": "FT836 With or Without Chemotherapy and/or Monoclonal Antibodies, in Participants With Advanced Solid Tumors",
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     {
      "nct": "NCT00004074",
      "title": "Interleukin-12 and Trastuzumab in Treating Patients With Cancer That Has High Levels of HER2/Neu",
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     {
      "nct": "NCT00005842",
      "title": "Trastuzumab Plus R115777 in Treating Patients With Advanced or Metastatic Cancer",
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      "title": "Trastuzumab in Treating Patients With Stage III, Stage IV, or Recurrent Endometrial Cancer",
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      "title": "Interleukin-12, Paclitaxel, and Trastuzumab in Treating Patients With Solid Tumors",
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     {
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      "title": "Open-Label, Dose-Escalation Study of Pemigatinib in Subjects With Advanced Malignancies - (FIGHT-101)",
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     {
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      "title": "Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)",
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      "last_update": "2026-08-28",
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      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT04188548",
      "title": "A Study of LY3484356 in Participants With Advanced or Metastatic Breast Cancer or Endometrial Cancer",
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      "last_update": "2026-06-22",
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     {
      "nct": "NCT04205630",
      "title": "SYD985 in Patients With HER2-expressing Recurrent, Advanced or Metastatic Endometrial Carcinoma",
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     {
      "nct": "NCT04278144",
      "title": "A First-in-human Study Using BDC-1001 as a Single Agent and in Combination With Nivolumab in Advanced HER2-Expressing Solid Tumors",
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     {
      "nct": "NCT04464967",
      "title": "Safety and Preliminary Efficacy of SNK01 in Combination With Trastuzumab or Cetuximab in Subjects With Advanced HER2 or EGFR Cancers",
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      "title": "A Phase 2 Study of T-DXd in Patients With Selected HER2 Expressing Tumors",
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      "nct": "NCT04602117",
      "title": "ISPY-P1.01:Evaluating the Safety of Weekly Paclitaxel With Trastuzumab Duocarmazine (SYD985) in Patients With Metastatic Cancer",
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      "last_update": "2023-11-18",
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     {
      "nct": "NCT04639219",
      "title": "A Study of T-DXd for the Treatment of Solid Tumors Harboring HER2 Activating Mutations",
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      "nct": "NCT04644068",
      "title": "Study of AZD5305 as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Malignancies",
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     {
      "nct": "NCT04704661",
      "title": "Testing the Combination of Two Anti-cancer Drugs, DS-8201a and AZD6738, for The Treatment of Advanced Solid Tumors Expressing the HER2 Protein or Gene, The DASH Trial",
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      "last_update": "2026-09-04",
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     {
      "nct": "NCT05069935",
      "title": "FT538 in Combination With Monoclonal Antibodies in Advanced Solid Tumors",
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     {
      "nct": "NCT05143970",
      "title": "A Phase 1 First-In-Human Study of the Anti-CD73 IPH5301 Alone or in Combination With Chemotherapy and Trastuzumab in Patients With Advanced Solid Tumors",
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      "title": "Oral Topotecan With Toripalimab for Patients With Endometrial Cancer",
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      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT07631884",
      "title": "Exploratory Study on the Efficacy and Safety of Trastuzumab Rezetecan in the Treatment of HER2-Expressiong Advanced Solid Tumor",
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      "last_update": "2026-06-08",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06989112",
      "title": "DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer",
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     {
      "nct": "NCT07022483",
      "title": "Study of Trastuzumab Deruxtecan Versus Standard of Care Chemotherapy for HER2-Expressing (IHC 3+/2+) Endometrial Cancer",
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     {
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     {
      "nct": "NCT04639219",
      "title": "A Study of T-DXd for the Treatment of Solid Tumors Harboring HER2 Activating Mutations",
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      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04644068",
      "title": "Study of AZD5305 as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Malignancies",
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      "phase": "PHASE1/PHASE2",
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     },
     {
      "nct": "NCT04704661",
      "title": "Testing the Combination of Two Anti-cancer Drugs, DS-8201a and AZD6738, for The Treatment of Advanced Solid Tumors Expressing the HER2 Protein or Gene, The DASH Trial",
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      "last_update": "2026-09-04",
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      "study_type": "INTERVENTIONAL"
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      "nct": "NCT04205630",
      "title": "SYD985 in Patients With HER2-expressing Recurrent, Advanced or Metastatic Endometrial Carcinoma",
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      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04602117",
      "title": "ISPY-P1.01:Evaluating the Safety of Weekly Paclitaxel With Trastuzumab Duocarmazine (SYD985) in Patients With Metastatic Cancer",
      "status": "WITHDRAWN",
      "last_update": "2023-11-18",
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      "study_type": "INTERVENTIONAL"
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      "nct": "NCT04486352",
      "title": "A Study of Targeted Agents for Patients With Recurrent or Persistent Endometrial Cancer",
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      "last_update": "2026-04-01",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02465060",
      "title": "Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)",
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      "last_update": "2026-08-28",
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      "study_type": "INTERVENTIONAL"
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    "trials": [
     {
      "nct": "NCT02440750",
      "title": "Endometrial Preparation Before Operative Hysteroscopy in Premenopausal Women",
      "status": "UNKNOWN",
      "last_update": "2016-03-09",
      "phase": "PHASE4",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06695845",
      "title": "A Phase 2 Study of Zanidatamab in Patients With HER2-expressing Tumors",
      "status": "RECRUITING",
      "last_update": "2026-07-10",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07192068",
      "title": "Clinical Trial Evaluating the Activity of Zanidatamab for the Treatment of Patients With Solid Tumors With an Alteration of the HER2 Gene.",
      "status": "RECRUITING",
      "last_update": "2025-12-19",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07631871",
      "title": "An Exploratory Study of Zanidatamab in HER2-positive Advanced Tumor After at Least One Line of Standard Therapy",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2026-06-08",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     }
    ]
   }
  }
 }
}