{"disease": {"name": "Gallbladder cancer", "mondo_id": null, "ncit_id": null, "umls_id": null, "oncotree_code": "gbc"}, "updated_at": "2026-09-18", "genome_builds": ["hg19"], "cohort_count": 2, "cohort_count_status": "observed", "cohort_count_unit": "cohorts", "evaluable_patients": null, "evaluable_patients_status": "unknown", "evaluable_patients_unit": "patients", "alteration_types": ["SNV", "small indel", "amplification", "deep deletion"], "genes": [{"gene": "ERBB2", "alteration_types": ["SNV / small indel", "amplification"], "altered": 17, "tested": 233, "frequency": 7.3, "cohort_count": 2, "frequency_range": {"min": 7.3, "max": 9.38}, "major_variants": ["S310F (n=5)", "S310Y (n=5)", "D769Y (n=3)", "L755S (n=2)", "R678Q (n=2)"], "evidence_confidence": "low", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Gallbladder Cancer (MSK, 2022)", "source_url": "https://www.cbioportal.org/study/summary?id=gbc_mskcc_2022", "source_record_id": "gbc_mskcc_2022", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Gallbladder Carcinoma (Shanghai, Nat Genet 2014)", "source_url": "https://www.cbioportal.org/study/summary?id=gbc_shanghai_2014", "source_record_id": "gbc_shanghai_2014", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Gallbladder Cancer (MSK, 2022), 17/233 patients (7.3%).", "Largest alteration is amplification: 24/233 (10.3%) in the reference cohort's copy-number profile.", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "gbc_mskcc_2022", "cohort_name": "Gallbladder Cancer (MSK, 2022)", "altered": 17, "tested": 233, "frequency": 7.3, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "244/244", "coverage_note": null, "source_id": "gbc_mskcc_2022", "is_reference": true}, {"cohort": "gbc_shanghai_2014", "cohort_name": "Gallbladder Carcinoma (Shanghai, Nat Genet 2014)", "altered": 3, "tested": 32, "frequency": 9.38, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "32/32", "coverage_note": null, "source_id": "gbc_shanghai_2014", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 34.33, "width": 1.0, "reference": 34.33, "scale_max": 30.0}, "headline_alteration": {"kind": "amplification", "altered": 24, "tested": 233, "frequency": 10.3, "is_mutation": false}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "TP53", "alteration_types": ["SNV / small indel"], "altered": 149, "tested": 233, "frequency": 63.95, "cohort_count": 2, "frequency_range": {"min": 25.0, "max": 63.95}, "major_variants": ["R248Q (n=9)", "R175H (n=7)", "R273H (n=5)", "Y234C (n=4)", "R306* (n=3)"], "evidence_confidence": "low", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Gallbladder Cancer (MSK, 2022)", "source_url": "https://www.cbioportal.org/study/summary?id=gbc_mskcc_2022", "source_record_id": "gbc_mskcc_2022", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Gallbladder Carcinoma (Shanghai, Nat Genet 2014)", "source_url": "https://www.cbioportal.org/study/summary?id=gbc_shanghai_2014", "source_record_id": "gbc_shanghai_2014", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Gallbladder Cancer (MSK, 2022), 149/233 patients (63.95%).", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "gbc_mskcc_2022", "cohort_name": "Gallbladder Cancer (MSK, 2022)", "altered": 149, "tested": 233, "frequency": 63.95, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "244/244", "coverage_note": null, "source_id": "gbc_mskcc_2022", "is_reference": true}, {"cohort": "gbc_shanghai_2014", "cohort_name": "Gallbladder Carcinoma (Shanghai, Nat Genet 2014)", "altered": 8, "tested": 32, "frequency": 25.0, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "32/32", "coverage_note": null, "source_id": "gbc_shanghai_2014", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 83.33, "width": 16.67, "reference": 100.0, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 149, "tested": 233, "frequency": 63.95, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "KRAS", "alteration_types": ["SNV / small indel", "amplification"], "altered": 18, "tested": 233, "frequency": 7.73, "cohort_count": 1, "frequency_range": {"min": 0.0, "max": 7.73}, "major_variants": ["G13D (n=5)", "G12D (n=5)", "Q61H (n=2)", "G12C (n=2)", "G12A (n=2)"], "evidence_confidence": "low", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Gallbladder Cancer (MSK, 2022)", "source_url": "https://www.cbioportal.org/study/summary?id=gbc_mskcc_2022", "source_record_id": "gbc_mskcc_2022", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Gallbladder Carcinoma (Shanghai, Nat Genet 2014)", "source_url": "https://www.cbioportal.org/study/summary?id=gbc_shanghai_2014", "source_record_id": "gbc_shanghai_2014", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Gallbladder Cancer (MSK, 2022), 18/233 patients (7.73%).", "Observed in 1 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "gbc_mskcc_2022", "cohort_name": "Gallbladder Cancer (MSK, 2022)", "altered": 18, "tested": 233, "frequency": 7.73, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "244/244", "coverage_note": null, "source_id": "gbc_mskcc_2022", "is_reference": true}, {"cohort": "gbc_shanghai_2014", "cohort_name": "Gallbladder Carcinoma (Shanghai, Nat Genet 2014)", "altered": 0, "tested": 32, "frequency": 0.0, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "32/32", "coverage_note": null, "source_id": "gbc_shanghai_2014", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 0.0, "width": 25.77, "reference": 25.77, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 18, "tested": 233, "frequency": 7.73, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "PIK3CA", "alteration_types": ["SNV / small indel", "amplification"], "altered": 25, "tested": 233, "frequency": 10.73, "cohort_count": 2, "frequency_range": {"min": 6.25, "max": 10.73}, "major_variants": ["E542K (n=6)", "E545K (n=4)", "H1047R (n=4)", "E81K (n=2)", "E726K (n=2)"], "evidence_confidence": "low", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Gallbladder Cancer (MSK, 2022)", "source_url": "https://www.cbioportal.org/study/summary?id=gbc_mskcc_2022", "source_record_id": "gbc_mskcc_2022", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Gallbladder Carcinoma (Shanghai, Nat Genet 2014)", "source_url": "https://www.cbioportal.org/study/summary?id=gbc_shanghai_2014", "source_record_id": "gbc_shanghai_2014", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Gallbladder Cancer (MSK, 2022), 25/233 patients (10.73%).", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "gbc_mskcc_2022", "cohort_name": "Gallbladder Cancer (MSK, 2022)", "altered": 25, "tested": 233, "frequency": 10.73, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "244/244", "coverage_note": null, "source_id": "gbc_mskcc_2022", "is_reference": true}, {"cohort": "gbc_shanghai_2014", "cohort_name": "Gallbladder Carcinoma (Shanghai, Nat Genet 2014)", "altered": 2, "tested": 32, "frequency": 6.25, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "32/32", "coverage_note": null, "source_id": "gbc_shanghai_2014", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 20.83, "width": 14.94, "reference": 35.77, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 25, "tested": 233, "frequency": 10.73, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "CDKN2A", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 23, "tested": 233, "frequency": 9.87, "cohort_count": 1, "frequency_range": {"min": 0.0, "max": 9.87}, "major_variants": ["R80* (n=3)", "R29_A34del (n=2)", "D84N (n=2)", "E120* (n=2)", "E10* (n=2)"], "evidence_confidence": "low", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Gallbladder Cancer (MSK, 2022)", "source_url": "https://www.cbioportal.org/study/summary?id=gbc_mskcc_2022", "source_record_id": "gbc_mskcc_2022", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Gallbladder Carcinoma (Shanghai, Nat Genet 2014)", "source_url": "https://www.cbioportal.org/study/summary?id=gbc_shanghai_2014", "source_record_id": "gbc_shanghai_2014", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Gallbladder Cancer (MSK, 2022), 23/233 patients (9.87%).", "Largest alteration is deep deletion: 35/233 (15.02%) in the reference cohort's copy-number profile.", "Observed in 1 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "gbc_mskcc_2022", "cohort_name": "Gallbladder Cancer (MSK, 2022)", "altered": 23, "tested": 233, "frequency": 9.87, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "244/244", "coverage_note": null, "source_id": "gbc_mskcc_2022", "is_reference": true}, {"cohort": "gbc_shanghai_2014", "cohort_name": "Gallbladder Carcinoma (Shanghai, Nat Genet 2014)", "altered": 0, "tested": 32, "frequency": 0.0, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "32/32", "coverage_note": null, "source_id": "gbc_shanghai_2014", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 50.07, "width": 1.0, "reference": 50.07, "scale_max": 30.0}, "headline_alteration": {"kind": "deep deletion", "altered": 35, "tested": 233, "frequency": 15.02, "is_mutation": false}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "ARID1A", "alteration_types": ["SNV / small indel", "deep deletion"], "altered": 48, "tested": 233, "frequency": 20.6, "cohort_count": 2, "frequency_range": {"min": 6.25, "max": 20.6}, "major_variants": ["Y551Lfs*72 (n=2)", "D322Y (n=2)", "Q1095del (n=2)", "Q515* (n=2)", "A1978Sfs*36 (n=1)"], "evidence_confidence": "low", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Gallbladder Cancer (MSK, 2022)", "source_url": "https://www.cbioportal.org/study/summary?id=gbc_mskcc_2022", "source_record_id": "gbc_mskcc_2022", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Gallbladder Carcinoma (Shanghai, Nat Genet 2014)", "source_url": "https://www.cbioportal.org/study/summary?id=gbc_shanghai_2014", "source_record_id": "gbc_shanghai_2014", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: 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"gbc_shanghai_2014", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 20.83, "width": 47.84, "reference": 68.67, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 48, "tested": 233, "frequency": 20.6, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "ERBB3", "alteration_types": ["SNV / small indel", "amplification"], "altered": 15, "tested": 233, "frequency": 6.44, "cohort_count": 2, "frequency_range": {"min": 6.44, "max": 9.38}, "major_variants": ["T355I (n=2)", "G914R (n=2)", "V104L (n=2)", "G284R (n=2)", "G994D (n=1)"], "evidence_confidence": "low", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Gallbladder Cancer (MSK, 2022)", "source_url": "https://www.cbioportal.org/study/summary?id=gbc_mskcc_2022", "source_record_id": "gbc_mskcc_2022", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Gallbladder Carcinoma (Shanghai, Nat Genet 2014)", "source_url": "https://www.cbioportal.org/study/summary?id=gbc_shanghai_2014", "source_record_id": "gbc_shanghai_2014", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Gallbladder Cancer (MSK, 2022), 15/233 patients (6.44%).", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "gbc_mskcc_2022", "cohort_name": "Gallbladder Cancer (MSK, 2022)", "altered": 15, "tested": 233, "frequency": 6.44, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "244/244", "coverage_note": null, "source_id": "gbc_mskcc_2022", "is_reference": true}, {"cohort": "gbc_shanghai_2014", "cohort_name": "Gallbladder Carcinoma (Shanghai, Nat Genet 2014)", "altered": 3, "tested": 32, "frequency": 9.38, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "32/32", "coverage_note": null, "source_id": "gbc_shanghai_2014", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 21.47, "width": 9.8, "reference": 21.47, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 15, "tested": 233, "frequency": 6.44, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "EGFR", "alteration_types": ["SNV / small indel", "amplification"], "altered": 3, "tested": 233, "frequency": 1.29, "cohort_count": 2, "frequency_range": {"min": 1.29, "max": 3.12}, "major_variants": ["V742I (n=1)", "V769_D770insG (n=1)", "N808D (n=1)"], "evidence_confidence": "low", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Gallbladder Cancer (MSK, 2022)", "source_url": "https://www.cbioportal.org/study/summary?id=gbc_mskcc_2022", "source_record_id": "gbc_mskcc_2022", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; 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"observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "CTNNB1", "alteration_types": ["SNV / small indel", "amplification"], "altered": 15, "tested": 233, "frequency": 6.44, "cohort_count": 1, "frequency_range": {"min": 0.0, "max": 6.44}, "major_variants": ["S45P (n=5)", "S37F (n=2)", "S45F (n=2)", "D32V (n=1)", "S33F (n=1)"], "evidence_confidence": "low", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Gallbladder Cancer (MSK, 2022)", "source_url": "https://www.cbioportal.org/study/summary?id=gbc_mskcc_2022", "source_record_id": "gbc_mskcc_2022", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Gallbladder Carcinoma (Shanghai, Nat Genet 2014)", "source_url": "https://www.cbioportal.org/study/summary?id=gbc_shanghai_2014", "source_record_id": "gbc_shanghai_2014", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; 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"is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 0.0, "width": 21.47, "reference": 21.47, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 15, "tested": 233, "frequency": 6.44, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "SMAD4", "alteration_types": ["SNV / small indel", "deep deletion"], "altered": 51, "tested": 233, "frequency": 21.89, "cohort_count": 2, "frequency_range": {"min": 3.12, "max": 21.89}, "major_variants": ["R361C (n=4)", "R361H (n=4)", "G386R (n=3)", "Q448* (n=2)", "D493G (n=2)"], "evidence_confidence": "low", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Gallbladder Cancer (MSK, 2022)", "source_url": "https://www.cbioportal.org/study/summary?id=gbc_mskcc_2022", "source_record_id": "gbc_mskcc_2022", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Gallbladder Carcinoma (Shanghai, Nat Genet 2014)", "source_url": "https://www.cbioportal.org/study/summary?id=gbc_shanghai_2014", "source_record_id": "gbc_shanghai_2014", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Gallbladder Cancer (MSK, 2022), 51/233 patients (21.89%).", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "gbc_mskcc_2022", "cohort_name": "Gallbladder Cancer (MSK, 2022)", "altered": 51, "tested": 233, "frequency": 21.89, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "244/244", "coverage_note": null, "source_id": "gbc_mskcc_2022", "is_reference": true}, {"cohort": "gbc_shanghai_2014", "cohort_name": "Gallbladder 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"frequency_range": {"min": 0.0, "max": 1.29}, "major_variants": ["F798L (n=1)", "G182E (n=1)", "T762Hfs*6 (n=1)"], "evidence_confidence": "low", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Gallbladder Cancer (MSK, 2022)", "source_url": "https://www.cbioportal.org/study/summary?id=gbc_mskcc_2022", "source_record_id": "gbc_mskcc_2022", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the 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"tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "IDH1", "alteration_types": ["SNV / small indel"], "altered": 1, "tested": 233, "frequency": 0.43, "cohort_count": 1, "frequency_range": {"min": 0.0, "max": 0.43}, "major_variants": ["M18I (n=1)"], "evidence_confidence": "low", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Gallbladder Cancer (MSK, 2022)", "source_url": "https://www.cbioportal.org/study/summary?id=gbc_mskcc_2022", "source_record_id": "gbc_mskcc_2022", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Gallbladder Carcinoma (Shanghai, Nat Genet 2014)", "source_url": "https://www.cbioportal.org/study/summary?id=gbc_shanghai_2014", "source_record_id": "gbc_shanghai_2014", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Gallbladder Cancer (MSK, 2022), 1/233 patients (0.43%).", "Observed in 1 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "gbc_mskcc_2022", "cohort_name": "Gallbladder Cancer (MSK, 2022)", "altered": 1, "tested": 233, "frequency": 0.43, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "244/244", "coverage_note": null, "source_id": "gbc_mskcc_2022", "is_reference": true}, {"cohort": "gbc_shanghai_2014", "cohort_name": "Gallbladder Carcinoma (Shanghai, Nat Genet 2014)", "altered": 0, "tested": 32, "frequency": 0.0, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "32/32", "coverage_note": null, "source_id": "gbc_shanghai_2014", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 0.0, "width": 1.43, "reference": 1.43, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 1, "tested": 233, "frequency": 0.43, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "STK11", "alteration_types": ["SNV / small indel", "deep deletion"], "altered": 22, "tested": 233, "frequency": 9.44, "cohort_count": 1, "frequency_range": {"min": 0.0, "max": 9.44}, "major_variants": ["L117Ifs*45 (n=1)", "S216F (n=1)", "C134_V143del (n=1)", "G251R (n=1)", "F255Sfs*32 (n=1)"], "evidence_confidence": "low", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's 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"patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Gallbladder Cancer (MSK, 2022), 22/233 patients (9.44%).", "Observed in 1 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "gbc_mskcc_2022", "cohort_name": "Gallbladder Cancer (MSK, 2022)", "altered": 22, "tested": 233, "frequency": 9.44, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "244/244", "coverage_note": null, "source_id": "gbc_mskcc_2022", "is_reference": true}, {"cohort": "gbc_shanghai_2014", "cohort_name": "Gallbladder Carcinoma (Shanghai, Nat Genet 2014)", "altered": 0, "tested": 32, "frequency": 0.0, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "32/32", "coverage_note": null, "source_id": "gbc_shanghai_2014", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 0.0, "width": 31.47, "reference": 31.47, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 22, "tested": 233, "frequency": 9.44, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "KMT2C", "alteration_types": ["SNV / small indel"], "altered": 20, "tested": 233, "frequency": 8.58, "cohort_count": 2, "frequency_range": {"min": 8.58, "max": 9.38}, "major_variants": ["Q2539* (n=1)", "P4655Sfs*5 (n=1)", "S2984Ffs*18 (n=1)", "Y4161Sfs*3 (n=1)", "R2307K (n=1)"], "evidence_confidence": "low", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Gallbladder Cancer (MSK, 2022)", "source_url": "https://www.cbioportal.org/study/summary?id=gbc_mskcc_2022", "source_record_id": "gbc_mskcc_2022", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as 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"https://www.cbioportal.org/study/summary?id=gbc_mskcc_2022", "source_record_id": "gbc_mskcc_2022", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Gallbladder Carcinoma (Shanghai, Nat Genet 2014)", "source_url": "https://www.cbioportal.org/study/summary?id=gbc_shanghai_2014", "source_record_id": "gbc_shanghai_2014", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": 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"retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Gallbladder Cancer (MSK, 2022), 13/233 patients (5.58%).", "Observed in 1 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "gbc_mskcc_2022", "cohort_name": "Gallbladder Cancer (MSK, 2022)", "altered": 13, "tested": 233, "frequency": 5.58, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "244/244", "coverage_note": null, "source_id": "gbc_mskcc_2022", "is_reference": true}, {"cohort": "gbc_shanghai_2014", "cohort_name": "Gallbladder Carcinoma (Shanghai, Nat Genet 2014)", "altered": 0, 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["M731I (n=1)", "R21H (n=1)", "X68_splice (n=1)", "A421Rfs*19 (n=1)", "A553Hfs*73 (n=1)"], "evidence_confidence": "low", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Gallbladder Cancer (MSK, 2022)", "source_url": "https://www.cbioportal.org/study/summary?id=gbc_mskcc_2022", "source_record_id": "gbc_mskcc_2022", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the 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Gallbladder Carcinoma (Shanghai, Nat Genet 2014)", "source_url": "https://www.cbioportal.org/study/summary?id=gbc_shanghai_2014", "source_record_id": "gbc_shanghai_2014", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Gallbladder Cancer (MSK, 2022), 7/225 patients (3.11%).", "Observed in 1 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "gbc_mskcc_2022", "cohort_name": "Gallbladder Cancer (MSK, 2022)", "altered": 7, "tested": 225, "frequency": 3.11, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "244/244", "coverage_note": null, "source_id": "gbc_mskcc_2022", "is_reference": true}, {"cohort": "gbc_shanghai_2014", "cohort_name": "Gallbladder Carcinoma (Shanghai, Nat Genet 2014)", "altered": 0, "tested": 32, "frequency": 0.0, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "32/32", "coverage_note": null, "source_id": "gbc_shanghai_2014", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 0.0, "width": 10.37, "reference": 10.37, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 7, "tested": 225, "frequency": 3.11, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "RNF43", "alteration_types": ["SNV / small indel", "deep deletion"], "altered": 7, "tested": 233, "frequency": 3.0, "cohort_count": 1, "frequency_range": {"min": 0.0, "max": 3.0}, "major_variants": ["G659Vfs*41 (n=3)", "R371* (n=2)", "P369T (n=1)", "I186F (n=1)", "S121* (n=1)"], "evidence_confidence": "low", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Gallbladder Cancer (MSK, 2022)", "source_url": "https://www.cbioportal.org/study/summary?id=gbc_mskcc_2022", "source_record_id": "gbc_mskcc_2022", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Gallbladder Carcinoma (Shanghai, Nat Genet 2014)", "source_url": "https://www.cbioportal.org/study/summary?id=gbc_shanghai_2014", "source_record_id": "gbc_shanghai_2014", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Gallbladder Cancer (MSK, 2022), 7/233 patients (3.0%).", "Observed in 1 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "gbc_mskcc_2022", "cohort_name": "Gallbladder Cancer (MSK, 2022)", "altered": 7, "tested": 233, "frequency": 3.0, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "244/244", "coverage_note": null, "source_id": "gbc_mskcc_2022", "is_reference": true}, {"cohort": "gbc_shanghai_2014", "cohort_name": "Gallbladder Carcinoma (Shanghai, Nat Genet 2014)", "altered": 0, "tested": 32, "frequency": 0.0, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "32/32", "coverage_note": null, "source_id": "gbc_shanghai_2014", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 0.0, "width": 10.0, "reference": 10.0, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 7, "tested": 233, "frequency": 3.0, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "PTPRS", "alteration_types": ["SNV / small indel"], "altered": 7, "tested": 233, "frequency": 3.0, "cohort_count": 2, "frequency_range": {"min": 3.0, "max": 3.12}, "major_variants": ["R148Q (n=2)", "Q1009H (n=1)", "R1696C (n=1)", "P1809L (n=1)", "E1928K (n=1)"], "evidence_confidence": "low", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Gallbladder Cancer (MSK, 2022)", "source_url": "https://www.cbioportal.org/study/summary?id=gbc_mskcc_2022", "source_record_id": "gbc_mskcc_2022", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Gallbladder Carcinoma (Shanghai, Nat Genet 2014)", "source_url": "https://www.cbioportal.org/study/summary?id=gbc_shanghai_2014", "source_record_id": "gbc_shanghai_2014", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Gallbladder Cancer (MSK, 2022), 7/233 patients (3.0%).", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "gbc_mskcc_2022", "cohort_name": "Gallbladder Cancer (MSK, 2022)", "altered": 7, "tested": 233, "frequency": 3.0, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "244/244", "coverage_note": null, "source_id": "gbc_mskcc_2022", "is_reference": true}, {"cohort": "gbc_shanghai_2014", "cohort_name": "Gallbladder Carcinoma (Shanghai, Nat Genet 2014)", "altered": 1, "tested": 32, "frequency": 3.12, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "32/32", "coverage_note": null, "source_id": "gbc_shanghai_2014", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 10.0, "width": 1.0, "reference": 10.0, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 7, "tested": 233, "frequency": 3.0, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "PTEN", "alteration_types": ["SNV / small indel", "deep deletion"], "altered": 7, "tested": 233, "frequency": 3.0, "cohort_count": 1, "frequency_range": {"min": 0.0, "max": 3.0}, "major_variants": ["R130Q (n=1)", "D19Gfs*25 (n=1)", "Q245* (n=1)", "K267Rfs*9 (n=1)", "R130* (n=1)"], "evidence_confidence": "low", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Gallbladder Cancer (MSK, 2022)", "source_url": "https://www.cbioportal.org/study/summary?id=gbc_mskcc_2022", "source_record_id": "gbc_mskcc_2022", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Gallbladder Carcinoma (Shanghai, Nat Genet 2014)", "source_url": "https://www.cbioportal.org/study/summary?id=gbc_shanghai_2014", "source_record_id": "gbc_shanghai_2014", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Gallbladder Cancer (MSK, 2022), 7/233 patients (3.0%).", "Observed in 1 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "gbc_mskcc_2022", "cohort_name": "Gallbladder Cancer (MSK, 2022)", "altered": 7, "tested": 233, "frequency": 3.0, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "244/244", "coverage_note": null, "source_id": "gbc_mskcc_2022", "is_reference": true}, {"cohort": "gbc_shanghai_2014", "cohort_name": "Gallbladder Carcinoma (Shanghai, Nat Genet 2014)", "altered": 0, "tested": 32, "frequency": 0.0, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "32/32", "coverage_note": null, "source_id": "gbc_shanghai_2014", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 0.0, "width": 10.0, "reference": 10.0, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 7, "tested": 233, "frequency": 3.0, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}], "variants": [], "genomic_events": [{"event_type": "copy_number", "gene": "CDKN2A", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "deep deletion", "event_label": "CDKN2A deep deletion", "genomic_coordinate": null, "observed": 35, "observed_status": "observed", "observed_unit": "patients", "tested": 233, "tested_status": "observed", "tested_unit": "patients", "frequency": 15.02, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["gbc_mskcc_2022"], "source_ids": ["gbc_mskcc_2022_cna"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "ERBB2", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "ERBB2 amplification", "genomic_coordinate": null, "observed": 24, "observed_status": "observed", "observed_unit": "patients", "tested": 233, "tested_status": "observed", "tested_unit": "patients", "frequency": 10.3, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["gbc_mskcc_2022"], "source_ids": ["gbc_mskcc_2022_cna"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "CDK12", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "CDK12 amplification", "genomic_coordinate": null, "observed": 16, "observed_status": "observed", "observed_unit": "patients", "tested": 233, "tested_status": "observed", "tested_unit": "patients", "frequency": 6.87, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["gbc_mskcc_2022"], "source_ids": ["gbc_mskcc_2022_cna"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "ERBB3", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "ERBB3 amplification", "genomic_coordinate": null, "observed": 12, "observed_status": "observed", "observed_unit": "patients", "tested": 233, "tested_status": "observed", "tested_unit": "patients", "frequency": 5.15, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["gbc_mskcc_2022"], "source_ids": ["gbc_mskcc_2022_cna"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "SMAD4", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "deep deletion", "event_label": "SMAD4 deep deletion", "genomic_coordinate": null, "observed": 11, "observed_status": "observed", "observed_unit": "patients", "tested": 233, "tested_status": "observed", "tested_unit": "patients", "frequency": 4.72, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["gbc_mskcc_2022"], "source_ids": ["gbc_mskcc_2022_cna"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "KRAS", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "KRAS amplification", "genomic_coordinate": null, "observed": 10, "observed_status": "observed", "observed_unit": "patients", "tested": 233, "tested_status": "observed", "tested_unit": "patients", "frequency": 4.29, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["gbc_mskcc_2022"], "source_ids": ["gbc_mskcc_2022_cna"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "EGFR", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "EGFR amplification", "genomic_coordinate": null, "observed": 8, "observed_status": "observed", "observed_unit": "patients", "tested": 233, "tested_status": "observed", "tested_unit": "patients", "frequency": 3.43, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["gbc_mskcc_2022"], "source_ids": ["gbc_mskcc_2022_cna"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "RB1", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "deep deletion", "event_label": "RB1 deep deletion", "genomic_coordinate": null, "observed": 7, "observed_status": "observed", "observed_unit": "patients", "tested": 233, "tested_status": "observed", "tested_unit": "patients", "frequency": 3.0, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["gbc_mskcc_2022"], "source_ids": ["gbc_mskcc_2022_cna"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "ARID1B", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "deep deletion", "event_label": "ARID1B deep deletion", "genomic_coordinate": null, "observed": 5, "observed_status": "observed", "observed_unit": "patients", "tested": 233, "tested_status": "observed", "tested_unit": "patients", "frequency": 2.15, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["gbc_mskcc_2022"], "source_ids": ["gbc_mskcc_2022_cna"], "evidence_confidence": "moderate", "details": null}], "modality_summary": [{"modality": "SNV / small indel", "available_cohorts": 2, "total_cohorts": 2}, {"modality": "Copy number (discrete)", "available_cohorts": 1, "total_cohorts": 2}, {"modality": "Structural variant (present, not read)", "available_cohorts": 1, "total_cohorts": 2}], "chromosome_summary": [], "cohorts": [{"name": "Gallbladder Cancer (MSK, 2022)", "source": "cBioPortal", "accession": "gbc_mskcc_2022", "patients": {"value": 233, "status": "observed", "unit": "patients"}, "samples": {"value": 244, "status": "observed", "unit": "samples"}, "disease_subtype": "Gallbladder Cancer (MSK, 2022)", "assay_type": "targeted panel", "sequencing_method": "IMPACT468 (151), IMPACT410 (44), IMPACT505 (40), IMPACT341 (9)", "genome_build": "hg19", "alteration_types_available": ["SNV", "small indel", "amplification", "deep deletion", "structural variant (profile present, not read)"], "genes_assayed": "panel genes only; per-gene denominators", "primary_or_metastatic": null, "age_group": null, "retrieved_at": "2026-09-18", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "source_record_id": "gbc_mskcc_2022", "is_demo": false, "assay_coverage": {"patients_with_calls": 233, "patients_in_roster": 233, "frequencies_computed": true, "samples_sequenced": 244, "samples_in_study": 244, "hypermutated_patients": 0, "median_mutations_per_sample": 5.0, "reason": null}}, {"name": "Gallbladder Carcinoma (Shanghai, Nat Genet 2014)", "source": "cBioPortal", "accession": "gbc_shanghai_2014", "patients": {"value": 32, "status": "observed", "unit": "patients"}, "samples": {"value": 32, "status": "observed", "unit": "samples"}, "disease_subtype": "Gallbladder Carcinoma (Shanghai, Nat Genet 2014)", "assay_type": "exome or genome", "sequencing_method": "WES (32)", "genome_build": "hg19", "alteration_types_available": ["SNV", "small indel"], "genes_assayed": "all coding genes", "primary_or_metastatic": null, "age_group": null, "retrieved_at": "2026-09-18", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "source_record_id": "gbc_shanghai_2014", "is_demo": false, "assay_coverage": {"patients_with_calls": 32, "patients_in_roster": 32, "frequencies_computed": true, "samples_sequenced": 32, "samples_in_study": 32, "hypermutated_patients": 0, "median_mutations_per_sample": 29.0, "reason": null}}], "sources": [{"source_name": "cBioPortal · Gallbladder Cancer (MSK, 2022)", "source_url": "https://www.cbioportal.org/study/summary?id=gbc_mskcc_2022", "source_record_id": "gbc_mskcc_2022", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Gallbladder Carcinoma (Shanghai, Nat Genet 2014)", "source_url": "https://www.cbioportal.org/study/summary?id=gbc_shanghai_2014", "source_record_id": "gbc_shanghai_2014", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "limitations": ["A cBioPortal public-API snapshot retrieved 2026-09-18; the page does not refresh source data at request time.", "Counts are patients with at least one non-silent call in the study's sequenced sample list; silent, intronic and UTR calls are excluded.", "For targeted-panel cohorts each gene divides by the patients whose panel carried it; a gene absent from the panel is shown as not assayed, not as zero.", "Copy-number rows use discrete calls (2 = high-level amplification, −2 = deep deletion) against the cohort's copy-number sample list, which is a different roster from the sequenced one.", "Cohorts are not pooled. Cross-study patient overlap has not been checked and no disease-wide frequency is reported.", "Structural variants and fusions are not read in this snapshot even where the study carries a profile; germline variants, mutational signatures, TMB and MSI are not reported.", "The gene set is the briefing's curated targets plus the reference cohort's most frequently mutated genes; it is not genome-wide."], "answer_block": ["In Gallbladder Cancer (MSK, 2022) (233 sequenced patients, targeted panel), the most frequently altered of the 43 genes shown are TP53 63.95%, SMAD4 21.89%, ARID1A 20.6%, CDKN2A 15.02% (deep deletion), ELF3 10.75%. Each figure divides by the patients on whom that gene could be called.", "Of the briefing's 12 curated targets, 2 are altered in under 2% of this cohort (FGFR2, IDH1): targets by expression, dependency or drug label, not by mutation. Frequency is not targetability, in either direction.", "2 cohorts are shown and none are pooled; overlap between them has not been checked and there is no disease-wide percentage."], "key_findings": [{"finding": "TP53 is mutated in 149 of 233 patients in Gallbladder Cancer (MSK, 2022).", "numerator": 149, "denominator": 233, "frequency": 63.95, "cohorts": 2, "evidence_confidence": "low", "source": "gbc_mskcc_2022", "retrieved_at": "2026-09-18"}, {"finding": "SMAD4 is mutated in 51 of 233 patients in Gallbladder Cancer (MSK, 2022).", "numerator": 51, "denominator": 233, "frequency": 21.89, "cohorts": 2, "evidence_confidence": "low", "source": "gbc_mskcc_2022", "retrieved_at": "2026-09-18"}, {"finding": "ARID1A is mutated in 48 of 233 patients in Gallbladder Cancer (MSK, 2022).", "numerator": 48, "denominator": 233, "frequency": 20.6, "cohorts": 2, "evidence_confidence": "low", "source": "gbc_mskcc_2022", "retrieved_at": "2026-09-18"}], "research_gaps": [{"kind": "Structural variants", "text": "Read the structural-variant profiles the studies carry; fusions are the defining event in several of these diseases."}, {"kind": "Context", "text": "Stage, subtype, age and treatment line are not attached to any count; the cohorts differ on all four."}, {"kind": "Interpretation", "text": "Activating versus inactivating, actionable versus not, and evidence level are not inferred here; the briefing's target table carries the drug and trial facts."}], "observations": [], "data_status": "PUBLIC SOURCE SNAPSHOT", "is_demo": false, "reference_cohort": "gbc_mskcc_2022", "region_events": [], "matrix": [{"label": "ERBB2", "kind": "SNV / small indel", "gene": "ERBB2", "cells": [{"cohort": "gbc_mskcc_2022", "status": "observed", "frequency": 7.3, "altered": 17, "tested": 233, "note": null}, {"cohort": "gbc_shanghai_2014", "status": "observed", "frequency": 9.38, "altered": 3, "tested": 32, "note": null}]}, {"label": "ERBB2", "kind": "amplification", "gene": "ERBB2", "cells": [{"cohort": "gbc_mskcc_2022", "status": "observed", "frequency": 10.3, "altered": 24, "tested": 233, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "gbc_shanghai_2014", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "No copy-number profile is connected for this cohort."}]}, {"label": "TP53", "kind": "SNV / small indel", "gene": "TP53", "cells": [{"cohort": "gbc_mskcc_2022", "status": "observed", "frequency": 63.95, "altered": 149, "tested": 233, "note": null}, {"cohort": "gbc_shanghai_2014", "status": "observed", "frequency": 25.0, "altered": 8, "tested": 32, "note": null}]}, {"label": "KRAS", "kind": "SNV / small indel", "gene": "KRAS", "cells": [{"cohort": "gbc_mskcc_2022", "status": "observed", "frequency": 7.73, "altered": 18, "tested": 233, "note": null}, {"cohort": "gbc_shanghai_2014", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 32, "note": null}]}, {"label": "KRAS", "kind": "amplification", "gene": "KRAS", "cells": [{"cohort": "gbc_mskcc_2022", "status": "observed", "frequency": 4.29, "altered": 10, "tested": 233, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "gbc_shanghai_2014", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "No copy-number profile is connected for this cohort."}]}, {"label": "PIK3CA", "kind": "SNV / small indel", "gene": "PIK3CA", "cells": [{"cohort": "gbc_mskcc_2022", "status": "observed", "frequency": 10.73, "altered": 25, "tested": 233, "note": null}, {"cohort": "gbc_shanghai_2014", "status": "observed", "frequency": 6.25, "altered": 2, "tested": 32, "note": null}]}, {"label": "CDKN2A", "kind": "SNV / small indel", "gene": "CDKN2A", "cells": [{"cohort": "gbc_mskcc_2022", "status": "observed", "frequency": 9.87, "altered": 23, "tested": 233, "note": null}, {"cohort": "gbc_shanghai_2014", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 32, "note": null}]}, {"label": "CDKN2A", "kind": "deep deletion", "gene": "CDKN2A", "cells": [{"cohort": "gbc_mskcc_2022", "status": "observed", "frequency": 15.02, "altered": 35, "tested": 233, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "gbc_shanghai_2014", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "No copy-number profile is connected for this cohort."}]}, {"label": "ARID1A", "kind": "SNV / small indel", "gene": "ARID1A", "cells": [{"cohort": "gbc_mskcc_2022", "status": "observed", "frequency": 20.6, "altered": 48, "tested": 233, "note": null}, {"cohort": "gbc_shanghai_2014", "status": "observed", "frequency": 6.25, "altered": 2, "tested": 32, "note": null}]}, {"label": "ERBB3", "kind": "SNV / small indel", "gene": "ERBB3", "cells": [{"cohort": "gbc_mskcc_2022", "status": "observed", "frequency": 6.44, "altered": 15, "tested": 233, "note": null}, {"cohort": "gbc_shanghai_2014", "status": "observed", "frequency": 9.38, "altered": 3, "tested": 32, "note": null}]}, {"label": "ERBB3", "kind": "amplification", "gene": "ERBB3", "cells": [{"cohort": "gbc_mskcc_2022", "status": "observed", "frequency": 5.15, "altered": 12, "tested": 233, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "gbc_shanghai_2014", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "No copy-number profile is connected for this cohort."}]}, {"label": "EGFR", "kind": "SNV / small indel", "gene": "EGFR", "cells": [{"cohort": "gbc_mskcc_2022", "status": "observed", "frequency": 1.29, "altered": 3, "tested": 233, "note": null}, {"cohort": "gbc_shanghai_2014", "status": "observed", "frequency": 3.12, "altered": 1, "tested": 32, "note": null}]}, {"label": "EGFR", "kind": "amplification", "gene": "EGFR", "cells": [{"cohort": "gbc_mskcc_2022", "status": "observed", "frequency": 3.43, "altered": 8, "tested": 233, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "gbc_shanghai_2014", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "No copy-number profile is connected for this cohort."}]}, {"label": "CTNNB1", "kind": "SNV / small indel", "gene": "CTNNB1", "cells": [{"cohort": "gbc_mskcc_2022", "status": "observed", "frequency": 6.44, "altered": 15, "tested": 233, "note": null}, {"cohort": "gbc_shanghai_2014", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 32, "note": null}]}, {"label": "SMAD4", "kind": "SNV / small indel", "gene": "SMAD4", "cells": [{"cohort": "gbc_mskcc_2022", "status": "observed", "frequency": 21.89, "altered": 51, "tested": 233, "note": null}, {"cohort": "gbc_shanghai_2014", "status": "observed", "frequency": 3.12, "altered": 1, "tested": 32, "note": null}]}, {"label": "SMAD4", "kind": "deep deletion", "gene": "SMAD4", "cells": [{"cohort": "gbc_mskcc_2022", "status": "observed", "frequency": 4.72, "altered": 11, "tested": 233, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "gbc_shanghai_2014", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "No copy-number profile is connected for this cohort."}]}, {"label": "FGFR2", "kind": "SNV / small indel", "gene": "FGFR2", "cells": [{"cohort": "gbc_mskcc_2022", "status": "observed", "frequency": 1.29, "altered": 3, "tested": 233, "note": null}, {"cohort": "gbc_shanghai_2014", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 32, "note": null}]}, {"label": "IDH1", "kind": "SNV / small indel", "gene": "IDH1", "cells": [{"cohort": "gbc_mskcc_2022", "status": "observed", "frequency": 0.43, "altered": 1, "tested": 233, "note": null}, {"cohort": "gbc_shanghai_2014", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 32, "note": null}]}, {"label": "STK11", "kind": "SNV / small indel", "gene": "STK11", "cells": [{"cohort": "gbc_mskcc_2022", "status": "observed", "frequency": 9.44, "altered": 22, "tested": 233, "note": null}, {"cohort": "gbc_shanghai_2014", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 32, "note": null}]}, {"label": "KMT2C", "kind": "SNV / small indel", "gene": "KMT2C", "cells": [{"cohort": "gbc_mskcc_2022", "status": "observed", "frequency": 8.58, "altered": 20, "tested": 233, "note": null}, {"cohort": "gbc_shanghai_2014", "status": "observed", "frequency": 9.38, "altered": 3, "tested": 32, "note": null}]}, {"label": "ELF3", "kind": "SNV / small indel", "gene": "ELF3", "cells": [{"cohort": "gbc_mskcc_2022", "status": "observed", "frequency": 10.75, "altered": 20, "tested": 186, "note": null}, {"cohort": "gbc_shanghai_2014", "status": "observed", "frequency": 6.25, "altered": 2, "tested": 32, "note": null}]}, {"label": "ARID2", "kind": "SNV / small indel", "gene": "ARID2", "cells": [{"cohort": "gbc_mskcc_2022", "status": "observed", "frequency": 8.58, "altered": 20, "tested": 233, "note": null}, {"cohort": "gbc_shanghai_2014", "status": "observed", "frequency": 6.25, "altered": 2, "tested": 32, "note": null}]}, {"label": "KMT2D", "kind": "SNV / small indel", "gene": "KMT2D", "cells": [{"cohort": "gbc_mskcc_2022", "status": "observed", "frequency": 6.87, "altered": 16, "tested": 233, "note": null}, {"cohort": "gbc_shanghai_2014", "status": "observed", "frequency": 3.12, "altered": 1, "tested": 32, "note": null}]}, {"label": "ATM", "kind": "SNV / small indel", "gene": "ATM", "cells": [{"cohort": "gbc_mskcc_2022", "status": "observed", "frequency": 6.87, "altered": 16, "tested": 233, "note": null}, {"cohort": "gbc_shanghai_2014", "status": "observed", "frequency": 3.12, "altered": 1, "tested": 32, "note": null}]}, {"label": "BRCA2", "kind": "SNV / small indel", "gene": "BRCA2", "cells": [{"cohort": "gbc_mskcc_2022", "status": "observed", "frequency": 5.58, "altered": 13, "tested": 233, "note": null}, {"cohort": "gbc_shanghai_2014", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 32, "note": null}]}, {"label": "RBM10", "kind": "SNV / small indel", "gene": "RBM10", "cells": [{"cohort": "gbc_mskcc_2022", "status": "observed", "frequency": 4.72, "altered": 11, "tested": 233, "note": null}, {"cohort": "gbc_shanghai_2014", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 32, "note": null}]}, {"label": "RB1", "kind": "SNV / small indel", "gene": "RB1", "cells": [{"cohort": "gbc_mskcc_2022", "status": "observed", "frequency": 4.29, "altered": 10, "tested": 233, "note": null}, {"cohort": "gbc_shanghai_2014", "status": "observed", "frequency": 3.12, "altered": 1, "tested": 32, "note": null}]}, {"label": "RB1", "kind": "deep deletion", "gene": "RB1", "cells": [{"cohort": "gbc_mskcc_2022", "status": "observed", "frequency": 3.0, "altered": 7, "tested": 233, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "gbc_shanghai_2014", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "No copy-number profile is connected for this cohort."}]}, {"label": "PBRM1", "kind": "SNV / small indel", "gene": "PBRM1", "cells": [{"cohort": "gbc_mskcc_2022", "status": "observed", "frequency": 4.29, "altered": 10, "tested": 233, "note": null}, {"cohort": "gbc_shanghai_2014", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 32, "note": null}]}, {"label": "NF1", "kind": "SNV / small indel", "gene": "NF1", "cells": [{"cohort": "gbc_mskcc_2022", "status": "observed", "frequency": 4.29, "altered": 10, "tested": 233, "note": null}, {"cohort": "gbc_shanghai_2014", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 32, "note": null}]}, {"label": "KMT2A", "kind": "SNV / small indel", "gene": "KMT2A", "cells": [{"cohort": "gbc_mskcc_2022", "status": "observed", "frequency": 4.29, "altered": 10, "tested": 233, "note": null}, {"cohort": "gbc_shanghai_2014", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 32, "note": null}]}, {"label": "SLX4", "kind": "SNV / small indel", "gene": "SLX4", "cells": [{"cohort": "gbc_mskcc_2022", "status": "observed", "frequency": 4.84, "altered": 9, "tested": 186, "note": null}, {"cohort": "gbc_shanghai_2014", "status": "observed", "frequency": 3.12, "altered": 1, "tested": 32, "note": null}]}, {"label": "PREX2", "kind": "SNV / small indel", "gene": "PREX2", "cells": [{"cohort": "gbc_mskcc_2022", "status": "observed", "frequency": 4.84, "altered": 9, "tested": 186, "note": null}, {"cohort": "gbc_shanghai_2014", "status": "observed", "frequency": 3.12, "altered": 1, "tested": 32, "note": null}]}, {"label": "KEAP1", "kind": "SNV / small indel", "gene": "KEAP1", "cells": [{"cohort": "gbc_mskcc_2022", "status": "observed", "frequency": 3.86, "altered": 9, "tested": 233, "note": null}, {"cohort": "gbc_shanghai_2014", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 32, "note": null}]}, {"label": "FBXW7", "kind": "SNV / small indel", "gene": "FBXW7", "cells": [{"cohort": "gbc_mskcc_2022", "status": "observed", "frequency": 3.86, "altered": 9, "tested": 233, "note": null}, {"cohort": "gbc_shanghai_2014", "status": "observed", "frequency": 3.12, "altered": 1, "tested": 32, "note": null}]}, {"label": "AXIN1", "kind": "SNV / small indel", "gene": "AXIN1", "cells": [{"cohort": "gbc_mskcc_2022", "status": "observed", "frequency": 3.86, "altered": 9, "tested": 233, "note": null}, {"cohort": "gbc_shanghai_2014", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 32, "note": null}]}, {"label": "ATRX", "kind": "SNV / small indel", "gene": "ATRX", "cells": [{"cohort": "gbc_mskcc_2022", "status": "observed", "frequency": 3.86, "altered": 9, "tested": 233, "note": null}, {"cohort": "gbc_shanghai_2014", "status": "observed", "frequency": 3.12, "altered": 1, "tested": 32, "note": null}]}, {"label": "RASA1", "kind": "SNV / small indel", "gene": "RASA1", "cells": [{"cohort": "gbc_mskcc_2022", "status": "observed", "frequency": 3.43, "altered": 8, "tested": 233, "note": null}, {"cohort": "gbc_shanghai_2014", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 32, "note": null}]}, {"label": "PTPRD", "kind": "SNV / small indel", "gene": "PTPRD", "cells": [{"cohort": "gbc_mskcc_2022", "status": "observed", "frequency": 3.43, "altered": 8, "tested": 233, "note": null}, {"cohort": "gbc_shanghai_2014", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 32, "note": null}]}, {"label": "NOTCH3", "kind": "SNV / small indel", "gene": "NOTCH3", "cells": [{"cohort": "gbc_mskcc_2022", "status": "observed", "frequency": 3.43, "altered": 8, "tested": 233, "note": null}, {"cohort": "gbc_shanghai_2014", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 32, "note": null}]}, {"label": "JAK1", "kind": "SNV / small indel", "gene": "JAK1", "cells": [{"cohort": "gbc_mskcc_2022", "status": "observed", "frequency": 3.43, "altered": 8, "tested": 233, "note": null}, {"cohort": "gbc_shanghai_2014", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 32, "note": null}]}, {"label": "IKZF1", "kind": "SNV / small indel", "gene": "IKZF1", "cells": [{"cohort": "gbc_mskcc_2022", "status": "observed", "frequency": 3.43, "altered": 8, "tested": 233, "note": null}, {"cohort": "gbc_shanghai_2014", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 32, "note": null}]}, {"label": "EP300", "kind": "SNV / small indel", "gene": "EP300", "cells": [{"cohort": "gbc_mskcc_2022", "status": "observed", "frequency": 3.43, "altered": 8, "tested": 233, "note": null}, {"cohort": "gbc_shanghai_2014", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 32, "note": null}]}, {"label": "CDK12", "kind": "SNV / small indel", "gene": "CDK12", "cells": [{"cohort": "gbc_mskcc_2022", "status": "observed", "frequency": 3.43, "altered": 8, "tested": 233, "note": null}, {"cohort": "gbc_shanghai_2014", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 32, "note": null}]}, {"label": "CDK12", "kind": "amplification", "gene": "CDK12", "cells": [{"cohort": "gbc_mskcc_2022", "status": "observed", "frequency": 6.87, "altered": 16, "tested": 233, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "gbc_shanghai_2014", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "No copy-number profile is connected for this cohort."}]}, {"label": "ARID1B", "kind": "SNV / small indel", "gene": "ARID1B", "cells": [{"cohort": "gbc_mskcc_2022", "status": "observed", "frequency": 3.43, "altered": 8, "tested": 233, "note": null}, {"cohort": "gbc_shanghai_2014", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 32, "note": null}]}, {"label": "ARID1B", "kind": "deep deletion", "gene": "ARID1B", "cells": [{"cohort": "gbc_mskcc_2022", "status": "observed", "frequency": 2.15, "altered": 5, "tested": 233, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "gbc_shanghai_2014", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "No copy-number profile is connected for this cohort."}]}, {"label": "APC", "kind": "SNV / small indel", "gene": "APC", "cells": [{"cohort": "gbc_mskcc_2022", "status": "observed", "frequency": 3.43, "altered": 8, "tested": 233, "note": null}, {"cohort": "gbc_shanghai_2014", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 32, "note": null}]}, {"label": "ZFHX3", "kind": "SNV / small indel", "gene": "ZFHX3", "cells": [{"cohort": "gbc_mskcc_2022", "status": "observed", "frequency": 3.11, "altered": 7, "tested": 225, "note": null}, {"cohort": "gbc_shanghai_2014", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 32, "note": null}]}, {"label": "RNF43", "kind": "SNV / small indel", "gene": "RNF43", "cells": [{"cohort": "gbc_mskcc_2022", "status": "observed", "frequency": 3.0, "altered": 7, "tested": 233, "note": null}, {"cohort": "gbc_shanghai_2014", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 32, "note": null}]}, {"label": "PTPRS", "kind": "SNV / small indel", "gene": "PTPRS", "cells": [{"cohort": "gbc_mskcc_2022", "status": "observed", "frequency": 3.0, "altered": 7, "tested": 233, "note": null}, {"cohort": "gbc_shanghai_2014", "status": "observed", "frequency": 3.12, "altered": 1, "tested": 32, "note": null}]}, {"label": "PTEN", "kind": "SNV / small indel", "gene": "PTEN", "cells": [{"cohort": "gbc_mskcc_2022", "status": "observed", "frequency": 3.0, "altered": 7, "tested": 233, "note": null}, {"cohort": "gbc_shanghai_2014", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 32, "note": null}]}]}