{"disease": {"name": "Gastric cancer", "mondo_id": null, "ncit_id": null, "umls_id": null, "oncotree_code": "stad"}, "updated_at": "2026-09-18", "genome_builds": ["hg19"], "cohort_count": 3, "cohort_count_status": "observed", "cohort_count_unit": "cohorts", "evaluable_patients": null, "evaluable_patients_status": "unknown", "evaluable_patients_unit": "patients", "alteration_types": ["SNV", "small indel", "amplification", "deep deletion"], "genes": [{"gene": "ERBB2", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 23, "tested": 436, "frequency": 5.28, "cohort_count": 3, "frequency_range": {"min": 4.32, "max": 8.84}, "major_variants": ["S310F (n=5)", "R678Q (n=4)", "A1039T (n=2)", "P269T (n=1)", "V777M (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_tcga_pan_can_atlas_2018", "source_record_id": "stad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Gastric Cancer (OncoSG, 2018)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_oncosg_2018", "source_record_id": "stad_oncosg_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=egc_msk_2023", "source_record_id": "egc_msk_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Stomach Adenocarcinoma (TCGA, PanCancer Atlas), 23/436 patients (5.28%).", "Without the 41 hypermutated patients: 18/395 (4.56%).", "Largest alteration is amplification: 58/438 (13.24%) in the reference cohort's copy-number profile.", "Observed in 3 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "stad_tcga_pan_can_atlas_2018", "cohort_name": "Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 23, "tested": 436, "frequency": 5.28, "frequency_excl_hypermutated": 4.56, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "436/440", "coverage_note": null, "source_id": "stad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "stad_oncosg_2018", "cohort_name": "Gastric Cancer (OncoSG, 2018)", "altered": 13, "tested": 147, "frequency": 8.84, "frequency_excl_hypermutated": 5.71, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "147/147", "coverage_note": null, "source_id": "stad_oncosg_2018", "is_reference": false}, {"cohort": "egc_msk_2023", "cohort_name": "Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "altered": 39, "tested": 902, "frequency": 4.32, "frequency_excl_hypermutated": 4.23, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "902/902", "coverage_note": null, "source_id": "egc_msk_2023", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 44.13, "width": 1.0, "reference": 44.13, "scale_max": 30.0}, "headline_alteration": {"kind": "amplification", "altered": 58, "tested": 438, "frequency": 13.24, "is_mutation": false}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "CLDN18", "alteration_types": ["SNV / small indel", "amplification"], "altered": 3, "tested": 436, "frequency": 0.69, "cohort_count": 2, "frequency_range": {"min": 0.68, "max": 0.69}, "major_variants": ["A23T (n=1)", "A227T (n=1)", "R80* (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_tcga_pan_can_atlas_2018", "source_record_id": "stad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Gastric Cancer (OncoSG, 2018)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_oncosg_2018", "source_record_id": "stad_oncosg_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=egc_msk_2023", "source_record_id": "egc_msk_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Stomach Adenocarcinoma (TCGA, PanCancer Atlas), 3/436 patients (0.69%).", "Without the 41 hypermutated patients: 0/395 (0.0%).", "Largest alteration is amplification: 7/438 (1.6%) in the reference cohort's copy-number profile.", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "stad_tcga_pan_can_atlas_2018", "cohort_name": "Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 3, "tested": 436, "frequency": 0.69, "frequency_excl_hypermutated": 0.0, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "436/440", "coverage_note": null, "source_id": "stad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "stad_oncosg_2018", "cohort_name": "Gastric Cancer (OncoSG, 2018)", "altered": 1, "tested": 147, "frequency": 0.68, "frequency_excl_hypermutated": 0.71, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "147/147", "coverage_note": null, "source_id": "stad_oncosg_2018", "is_reference": false}, {"cohort": "egc_msk_2023", "cohort_name": "Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "902/902", "coverage_note": null, "source_id": "egc_msk_2023", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 5.33, "width": 1.0, "reference": 5.33, "scale_max": 30.0}, "headline_alteration": {"kind": "amplification", "altered": 7, "tested": 438, "frequency": 1.6, "is_mutation": false}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "FGFR2", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 16, "tested": 436, "frequency": 3.67, "cohort_count": 2, "frequency_range": {"min": 0.0, "max": 3.67}, "major_variants": ["T370A (n=1)", "E335D (n=1)", "A97V (n=1)", "D655G (n=1)", "G570R (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_tcga_pan_can_atlas_2018", "source_record_id": "stad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Gastric Cancer (OncoSG, 2018)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_oncosg_2018", "source_record_id": "stad_oncosg_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=egc_msk_2023", "source_record_id": "egc_msk_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Stomach Adenocarcinoma (TCGA, PanCancer Atlas), 16/436 patients (3.67%).", "Without the 41 hypermutated patients: 9/395 (2.28%).", "Largest alteration is amplification: 19/438 (4.34%) in the reference cohort's copy-number profile.", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "stad_tcga_pan_can_atlas_2018", "cohort_name": "Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 16, "tested": 436, "frequency": 3.67, "frequency_excl_hypermutated": 2.28, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "436/440", "coverage_note": null, "source_id": "stad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "stad_oncosg_2018", "cohort_name": "Gastric Cancer (OncoSG, 2018)", "altered": 0, "tested": 147, "frequency": 0.0, "frequency_excl_hypermutated": 0.0, "counting_unit": "patients", "status": "not_observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "147/147", "coverage_note": null, "source_id": "stad_oncosg_2018", "is_reference": false}, {"cohort": "egc_msk_2023", "cohort_name": "Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "altered": 14, "tested": 902, "frequency": 1.55, "frequency_excl_hypermutated": 1.45, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "902/902", "coverage_note": null, "source_id": "egc_msk_2023", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 14.47, "width": 1.0, "reference": 14.47, "scale_max": 30.0}, "headline_alteration": {"kind": "amplification", "altered": 19, "tested": 438, "frequency": 4.34, "is_mutation": false}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "MET", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 7, "tested": 436, "frequency": 1.61, "cohort_count": 3, "frequency_range": {"min": 0.68, "max": 1.61}, "major_variants": ["N1100D (n=1)", "A320V (n=1)", "N393K (n=1)", "L815Pfs*18 (n=1)", "X1211_splice (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_tcga_pan_can_atlas_2018", "source_record_id": "stad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Gastric Cancer (OncoSG, 2018)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_oncosg_2018", "source_record_id": "stad_oncosg_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=egc_msk_2023", "source_record_id": "egc_msk_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Stomach Adenocarcinoma (TCGA, PanCancer Atlas), 7/436 patients (1.61%).", "Without the 41 hypermutated patients: 2/395 (0.51%).", "Largest alteration is amplification: 12/438 (2.74%) in the reference cohort's copy-number profile.", "Observed in 3 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "stad_tcga_pan_can_atlas_2018", "cohort_name": "Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 7, "tested": 436, "frequency": 1.61, "frequency_excl_hypermutated": 0.51, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "436/440", "coverage_note": null, "source_id": "stad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "stad_oncosg_2018", "cohort_name": "Gastric Cancer (OncoSG, 2018)", "altered": 1, "tested": 147, "frequency": 0.68, "frequency_excl_hypermutated": 0.71, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "147/147", "coverage_note": null, "source_id": "stad_oncosg_2018", "is_reference": false}, {"cohort": "egc_msk_2023", "cohort_name": "Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "altered": 14, "tested": 902, "frequency": 1.55, "frequency_excl_hypermutated": 1.45, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "902/902", "coverage_note": null, "source_id": "egc_msk_2023", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 9.13, "width": 1.0, "reference": 9.13, "scale_max": 30.0}, "headline_alteration": {"kind": "amplification", "altered": 12, "tested": 438, "frequency": 2.74, "is_mutation": false}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "TP53", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 212, "tested": 436, "frequency": 48.62, "cohort_count": 3, "frequency_range": {"min": 45.58, "max": 67.74}, "major_variants": ["R175H (n=12)", "R273H (n=10)", "R273C (n=7)", "R282W (n=7)", "R213* (n=6)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_tcga_pan_can_atlas_2018", "source_record_id": "stad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Gastric Cancer (OncoSG, 2018)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_oncosg_2018", "source_record_id": "stad_oncosg_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=egc_msk_2023", "source_record_id": "egc_msk_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Stomach Adenocarcinoma (TCGA, PanCancer Atlas), 212/436 patients (48.62%).", "Without the 41 hypermutated patients: 197/395 (49.87%).", "Observed in 3 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "stad_tcga_pan_can_atlas_2018", "cohort_name": "Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 212, "tested": 436, "frequency": 48.62, "frequency_excl_hypermutated": 49.87, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "436/440", "coverage_note": null, "source_id": "stad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "stad_oncosg_2018", "cohort_name": "Gastric Cancer (OncoSG, 2018)", "altered": 67, "tested": 147, "frequency": 45.58, "frequency_excl_hypermutated": 47.14, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "147/147", "coverage_note": null, "source_id": "stad_oncosg_2018", "is_reference": false}, {"cohort": "egc_msk_2023", "cohort_name": "Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "altered": 611, "tested": 902, "frequency": 67.74, "frequency_excl_hypermutated": 67.82, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "902/902", "coverage_note": null, "source_id": "egc_msk_2023", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 100.0, "width": 1.0, "reference": 100.0, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 212, "tested": 436, "frequency": 48.62, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "CDH1", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 41, "tested": 436, "frequency": 9.4, "cohort_count": 3, "frequency_range": {"min": 6.12, "max": 10.31}, "major_variants": ["D254Y (n=3)", "X229_splice (n=2)", "Y190C (n=2)", "K440N (n=2)", "S70Pfs*13 (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_tcga_pan_can_atlas_2018", "source_record_id": "stad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Gastric Cancer (OncoSG, 2018)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_oncosg_2018", "source_record_id": "stad_oncosg_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=egc_msk_2023", "source_record_id": "egc_msk_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Stomach Adenocarcinoma (TCGA, PanCancer Atlas), 41/436 patients (9.4%).", "Without the 41 hypermutated patients: 35/395 (8.86%).", "Observed in 3 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "stad_tcga_pan_can_atlas_2018", "cohort_name": "Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 41, "tested": 436, "frequency": 9.4, "frequency_excl_hypermutated": 8.86, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "436/440", "coverage_note": null, "source_id": "stad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "stad_oncosg_2018", "cohort_name": "Gastric Cancer (OncoSG, 2018)", "altered": 9, "tested": 147, "frequency": 6.12, "frequency_excl_hypermutated": 2.86, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "147/147", "coverage_note": null, "source_id": "stad_oncosg_2018", "is_reference": false}, {"cohort": "egc_msk_2023", "cohort_name": "Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "altered": 93, "tested": 902, "frequency": 10.31, "frequency_excl_hypermutated": 10.24, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "902/902", "coverage_note": null, "source_id": "egc_msk_2023", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 20.4, "width": 13.97, "reference": 31.33, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 41, "tested": 436, "frequency": 9.4, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "PIK3CA", "alteration_types": ["SNV / small indel", "amplification"], "altered": 71, "tested": 436, "frequency": 16.28, "cohort_count": 3, "frequency_range": {"min": 4.76, "max": 16.28}, "major_variants": ["H1047R (n=16)", "E545K (n=10)", "E542K (n=6)", "R88Q (n=6)", "N345K (n=5)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_tcga_pan_can_atlas_2018", "source_record_id": "stad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Gastric Cancer (OncoSG, 2018)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_oncosg_2018", "source_record_id": "stad_oncosg_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=egc_msk_2023", "source_record_id": "egc_msk_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Stomach Adenocarcinoma (TCGA, PanCancer Atlas), 71/436 patients (16.28%).", "Without the 41 hypermutated patients: 49/395 (12.41%).", "Observed in 3 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "stad_tcga_pan_can_atlas_2018", "cohort_name": "Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 71, "tested": 436, "frequency": 16.28, "frequency_excl_hypermutated": 12.41, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "436/440", "coverage_note": null, "source_id": "stad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "stad_oncosg_2018", "cohort_name": "Gastric Cancer (OncoSG, 2018)", "altered": 7, "tested": 147, "frequency": 4.76, "frequency_excl_hypermutated": 3.57, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "147/147", "coverage_note": null, "source_id": "stad_oncosg_2018", "is_reference": false}, {"cohort": "egc_msk_2023", "cohort_name": "Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "altered": 79, "tested": 902, "frequency": 8.76, "frequency_excl_hypermutated": 8.57, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "902/902", "coverage_note": null, "source_id": "egc_msk_2023", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 15.87, "width": 38.4, "reference": 54.27, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 71, "tested": 436, "frequency": 16.28, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "KRAS", "alteration_types": ["SNV / small indel", "amplification"], "altered": 40, "tested": 436, "frequency": 9.17, "cohort_count": 3, "frequency_range": {"min": 6.12, "max": 9.17}, "major_variants": ["G13D (n=11)", "G12D (n=10)", "G12S (n=4)", "A146T (n=3)", "G12V (n=3)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_tcga_pan_can_atlas_2018", "source_record_id": "stad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Gastric Cancer (OncoSG, 2018)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_oncosg_2018", "source_record_id": "stad_oncosg_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=egc_msk_2023", "source_record_id": "egc_msk_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Stomach Adenocarcinoma (TCGA, PanCancer Atlas), 40/436 patients (9.17%).", "Without the 41 hypermutated patients: 28/395 (7.09%).", "Observed in 3 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "stad_tcga_pan_can_atlas_2018", "cohort_name": "Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 40, "tested": 436, "frequency": 9.17, "frequency_excl_hypermutated": 7.09, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "436/440", "coverage_note": null, "source_id": "stad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "stad_oncosg_2018", "cohort_name": "Gastric Cancer (OncoSG, 2018)", "altered": 9, "tested": 147, "frequency": 6.12, "frequency_excl_hypermutated": 5.0, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "147/147", "coverage_note": null, "source_id": "stad_oncosg_2018", "is_reference": false}, {"cohort": "egc_msk_2023", "cohort_name": "Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "altered": 62, "tested": 902, "frequency": 6.87, "frequency_excl_hypermutated": 6.9, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "902/902", "coverage_note": null, "source_id": "egc_msk_2023", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 20.4, "width": 10.17, "reference": 30.57, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 40, "tested": 436, "frequency": 9.17, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "ARID1A", "alteration_types": ["SNV / small indel", "deep deletion", "amplification"], "altered": 110, "tested": 436, "frequency": 25.23, "cohort_count": 3, "frequency_range": {"min": 11.56, "max": 25.23}, "major_variants": ["D1850Tfs*33 (n=14)", "F2141Sfs*59 (n=7)", "Q766Sfs*67 (n=3)", "K1072Nfs*21 (n=3)", "D1850Gfs*4 (n=2)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_tcga_pan_can_atlas_2018", "source_record_id": "stad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Gastric Cancer (OncoSG, 2018)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_oncosg_2018", "source_record_id": "stad_oncosg_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=egc_msk_2023", "source_record_id": "egc_msk_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Stomach Adenocarcinoma (TCGA, PanCancer Atlas), 110/436 patients (25.23%).", "Without the 41 hypermutated patients: 77/395 (19.49%).", "Observed in 3 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "stad_tcga_pan_can_atlas_2018", "cohort_name": "Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 110, "tested": 436, "frequency": 25.23, "frequency_excl_hypermutated": 19.49, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "436/440", "coverage_note": null, "source_id": "stad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "stad_oncosg_2018", "cohort_name": "Gastric Cancer (OncoSG, 2018)", "altered": 17, "tested": 147, "frequency": 11.56, "frequency_excl_hypermutated": 9.29, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "147/147", "coverage_note": null, "source_id": "stad_oncosg_2018", "is_reference": false}, {"cohort": "egc_msk_2023", "cohort_name": "Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "altered": 135, "tested": 902, "frequency": 14.97, "frequency_excl_hypermutated": 14.7, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "902/902", "coverage_note": null, "source_id": "egc_msk_2023", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 38.53, "width": 45.57, "reference": 84.1, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 110, "tested": 436, "frequency": 25.23, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "RHOA", "alteration_types": ["SNV / small indel", "deep deletion", "amplification"], "altered": 22, "tested": 436, "frequency": 5.05, "cohort_count": 3, "frequency_range": {"min": 2.72, "max": 5.21}, "major_variants": ["Y42C (n=3)", "L57V (n=2)", "Y34C (n=2)", "Y42S (n=2)", "G62E (n=2)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_tcga_pan_can_atlas_2018", "source_record_id": "stad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Gastric Cancer (OncoSG, 2018)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_oncosg_2018", "source_record_id": "stad_oncosg_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=egc_msk_2023", "source_record_id": "egc_msk_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Stomach Adenocarcinoma (TCGA, PanCancer Atlas), 22/436 patients (5.05%).", "Without the 41 hypermutated patients: 21/395 (5.32%).", "Observed in 3 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "stad_tcga_pan_can_atlas_2018", "cohort_name": "Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 22, "tested": 436, "frequency": 5.05, "frequency_excl_hypermutated": 5.32, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "436/440", "coverage_note": null, "source_id": "stad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "stad_oncosg_2018", "cohort_name": "Gastric Cancer (OncoSG, 2018)", "altered": 4, "tested": 147, "frequency": 2.72, "frequency_excl_hypermutated": 2.14, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "147/147", "coverage_note": null, "source_id": "stad_oncosg_2018", "is_reference": false}, {"cohort": "egc_msk_2023", "cohort_name": "Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "altered": 47, "tested": 902, "frequency": 5.21, "frequency_excl_hypermutated": 5.23, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "902/902", "coverage_note": null, "source_id": "egc_msk_2023", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 9.07, "width": 8.3, "reference": 16.83, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 22, "tested": 436, "frequency": 5.05, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "CD274", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 4, "tested": 436, "frequency": 0.92, "cohort_count": 3, "frequency_range": {"min": 0.11, "max": 0.92}, "major_variants": ["T290M (n=1)", "R86W (n=1)", "E60K (n=1)", "A5D (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_tcga_pan_can_atlas_2018", "source_record_id": "stad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Gastric Cancer (OncoSG, 2018)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_oncosg_2018", "source_record_id": "stad_oncosg_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=egc_msk_2023", "source_record_id": "egc_msk_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Stomach Adenocarcinoma (TCGA, PanCancer Atlas), 4/436 patients (0.92%).", "Without the 41 hypermutated patients: 1/395 (0.25%).", "Largest alteration is deep deletion: 11/438 (2.51%) in the reference cohort's copy-number profile.", "Observed in 3 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "stad_tcga_pan_can_atlas_2018", "cohort_name": "Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 4, "tested": 436, "frequency": 0.92, "frequency_excl_hypermutated": 0.25, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "436/440", "coverage_note": null, "source_id": "stad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "stad_oncosg_2018", "cohort_name": "Gastric Cancer (OncoSG, 2018)", "altered": 1, "tested": 147, "frequency": 0.68, "frequency_excl_hypermutated": 0.71, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "147/147", "coverage_note": null, "source_id": "stad_oncosg_2018", "is_reference": false}, {"cohort": "egc_msk_2023", "cohort_name": "Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "altered": 1, "tested": 902, "frequency": 0.11, "frequency_excl_hypermutated": 0.11, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "902/902", "coverage_note": null, "source_id": "egc_msk_2023", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 8.37, "width": 1.0, "reference": 8.37, "scale_max": 30.0}, "headline_alteration": {"kind": "deep deletion", "altered": 11, "tested": 438, "frequency": 2.51, "is_mutation": false}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "KDR", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 14, "tested": 436, "frequency": 3.21, "cohort_count": 3, "frequency_range": {"min": 1.44, "max": 3.4}, "major_variants": ["R1022* (n=1)", "S691Y (n=1)", "M1016K (n=1)", "R787Q (n=1)", "R720Q (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_tcga_pan_can_atlas_2018", "source_record_id": "stad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Gastric Cancer (OncoSG, 2018)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_oncosg_2018", "source_record_id": "stad_oncosg_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=egc_msk_2023", "source_record_id": "egc_msk_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Stomach Adenocarcinoma (TCGA, PanCancer Atlas), 14/436 patients (3.21%).", "Without the 41 hypermutated patients: 11/395 (2.78%).", "Observed in 3 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "stad_tcga_pan_can_atlas_2018", "cohort_name": "Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 14, "tested": 436, "frequency": 3.21, "frequency_excl_hypermutated": 2.78, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "436/440", "coverage_note": null, "source_id": "stad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "stad_oncosg_2018", "cohort_name": "Gastric Cancer (OncoSG, 2018)", "altered": 5, "tested": 147, "frequency": 3.4, "frequency_excl_hypermutated": 2.14, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "147/147", "coverage_note": null, "source_id": "stad_oncosg_2018", "is_reference": false}, {"cohort": "egc_msk_2023", "cohort_name": "Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "altered": 13, "tested": 902, "frequency": 1.44, "frequency_excl_hypermutated": 1.34, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "902/902", "coverage_note": null, "source_id": "egc_msk_2023", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 4.8, "width": 6.53, "reference": 10.7, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 14, "tested": 436, "frequency": 3.21, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "KMT2D", "alteration_types": ["SNV / small indel", "deep deletion", "amplification"], "altered": 73, "tested": 436, "frequency": 16.74, "cohort_count": 3, "frequency_range": {"min": 4.08, "max": 16.74}, "major_variants": ["P2354Lfs*30 (n=5)", "L656Cfs*274 (n=4)", "N2517Ifs*26 (n=2)", "G1235Vfs*95 (n=2)", "R4238C (n=2)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_tcga_pan_can_atlas_2018", "source_record_id": "stad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Gastric Cancer (OncoSG, 2018)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_oncosg_2018", "source_record_id": "stad_oncosg_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=egc_msk_2023", "source_record_id": "egc_msk_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Stomach Adenocarcinoma (TCGA, PanCancer Atlas), 73/436 patients (16.74%).", "Without the 41 hypermutated patients: 41/395 (10.38%).", "Observed in 3 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "stad_tcga_pan_can_atlas_2018", "cohort_name": "Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 73, "tested": 436, "frequency": 16.74, "frequency_excl_hypermutated": 10.38, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "436/440", "coverage_note": null, "source_id": "stad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "stad_oncosg_2018", "cohort_name": "Gastric Cancer (OncoSG, 2018)", "altered": 6, "tested": 147, "frequency": 4.08, "frequency_excl_hypermutated": 2.14, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "147/147", "coverage_note": null, "source_id": "stad_oncosg_2018", "is_reference": false}, {"cohort": "egc_msk_2023", "cohort_name": "Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "altered": 97, "tested": 902, "frequency": 10.75, "frequency_excl_hypermutated": 10.47, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "902/902", "coverage_note": null, "source_id": "egc_msk_2023", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 13.6, "width": 42.2, "reference": 55.8, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 73, "tested": 436, "frequency": 16.74, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "PCDH15", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 71, "tested": 436, "frequency": 16.28, "cohort_count": 2, "frequency_range": {"min": 8.16, "max": 16.28}, "major_variants": ["Q1876R (n=2)", "E1878D (n=2)", "K360N (n=1)", "A1735V (n=1)", "R966G (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_tcga_pan_can_atlas_2018", "source_record_id": "stad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Gastric Cancer (OncoSG, 2018)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_oncosg_2018", "source_record_id": "stad_oncosg_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=egc_msk_2023", "source_record_id": "egc_msk_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Stomach Adenocarcinoma (TCGA, PanCancer Atlas), 71/436 patients (16.28%).", "Without the 41 hypermutated patients: 55/395 (13.92%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "stad_tcga_pan_can_atlas_2018", "cohort_name": "Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 71, "tested": 436, "frequency": 16.28, "frequency_excl_hypermutated": 13.92, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "436/440", "coverage_note": null, "source_id": "stad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "stad_oncosg_2018", "cohort_name": "Gastric Cancer (OncoSG, 2018)", "altered": 12, "tested": 147, "frequency": 8.16, "frequency_excl_hypermutated": 7.86, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "147/147", "coverage_note": null, "source_id": "stad_oncosg_2018", "is_reference": false}, {"cohort": "egc_msk_2023", "cohort_name": "Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "902/902", "coverage_note": null, "source_id": "egc_msk_2023", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 27.2, "width": 27.07, "reference": 54.27, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 71, "tested": 436, "frequency": 16.28, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "COL12A1", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 62, "tested": 436, "frequency": 14.22, "cohort_count": 2, "frequency_range": {"min": 7.48, "max": 14.22}, "major_variants": ["P3026Lfs*51 (n=2)", "R933C (n=2)", "E1642Sfs*5 (n=2)", "R1965H (n=2)", "D1951N (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_tcga_pan_can_atlas_2018", "source_record_id": "stad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Gastric Cancer (OncoSG, 2018)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_oncosg_2018", "source_record_id": "stad_oncosg_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=egc_msk_2023", "source_record_id": "egc_msk_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Stomach Adenocarcinoma (TCGA, PanCancer Atlas), 62/436 patients (14.22%).", "Without the 41 hypermutated patients: 40/395 (10.13%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "stad_tcga_pan_can_atlas_2018", "cohort_name": "Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 62, "tested": 436, "frequency": 14.22, "frequency_excl_hypermutated": 10.13, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "436/440", "coverage_note": null, "source_id": "stad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "stad_oncosg_2018", "cohort_name": "Gastric Cancer (OncoSG, 2018)", "altered": 11, "tested": 147, "frequency": 7.48, "frequency_excl_hypermutated": 7.14, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "147/147", "coverage_note": null, "source_id": "stad_oncosg_2018", "is_reference": false}, {"cohort": "egc_msk_2023", "cohort_name": "Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "902/902", "coverage_note": null, "source_id": "egc_msk_2023", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 24.93, "width": 22.47, "reference": 47.4, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 62, "tested": 436, "frequency": 14.22, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "LRRK2", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 61, "tested": 436, "frequency": 13.99, "cohort_count": 2, "frequency_range": {"min": 4.08, "max": 13.99}, "major_variants": ["R1639Gfs*15 (n=2)", "Q930* (n=1)", "L929F (n=1)", "L505R (n=1)", "L1211P (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_tcga_pan_can_atlas_2018", "source_record_id": "stad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Gastric Cancer (OncoSG, 2018)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_oncosg_2018", "source_record_id": "stad_oncosg_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=egc_msk_2023", "source_record_id": "egc_msk_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Stomach Adenocarcinoma (TCGA, PanCancer Atlas), 61/436 patients (13.99%).", "Without the 41 hypermutated patients: 46/395 (11.65%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "stad_tcga_pan_can_atlas_2018", "cohort_name": "Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 61, "tested": 436, "frequency": 13.99, "frequency_excl_hypermutated": 11.65, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "436/440", "coverage_note": null, "source_id": "stad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "stad_oncosg_2018", "cohort_name": "Gastric Cancer (OncoSG, 2018)", "altered": 6, "tested": 147, "frequency": 4.08, "frequency_excl_hypermutated": 2.86, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "147/147", "coverage_note": null, "source_id": "stad_oncosg_2018", "is_reference": false}, {"cohort": "egc_msk_2023", "cohort_name": "Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "902/902", "coverage_note": null, "source_id": "egc_msk_2023", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 13.6, "width": 33.03, "reference": 46.63, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 61, "tested": 436, "frequency": 13.99, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "LAMA1", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 61, "tested": 436, "frequency": 13.99, "cohort_count": 2, "frequency_range": {"min": 7.48, "max": 13.99}, "major_variants": ["N496K (n=2)", "E1777K (n=1)", "V1856D (n=1)", "A2030V (n=1)", "L773F (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_tcga_pan_can_atlas_2018", "source_record_id": "stad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Gastric Cancer (OncoSG, 2018)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_oncosg_2018", "source_record_id": "stad_oncosg_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=egc_msk_2023", "source_record_id": "egc_msk_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Stomach Adenocarcinoma (TCGA, PanCancer Atlas), 61/436 patients (13.99%).", "Without the 41 hypermutated patients: 41/395 (10.38%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "stad_tcga_pan_can_atlas_2018", "cohort_name": "Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 61, "tested": 436, "frequency": 13.99, "frequency_excl_hypermutated": 10.38, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "436/440", "coverage_note": null, "source_id": "stad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "stad_oncosg_2018", "cohort_name": "Gastric Cancer (OncoSG, 2018)", "altered": 11, "tested": 147, "frequency": 7.48, "frequency_excl_hypermutated": 6.43, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "147/147", "coverage_note": null, "source_id": "stad_oncosg_2018", "is_reference": false}, {"cohort": "egc_msk_2023", "cohort_name": "Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "902/902", "coverage_note": null, "source_id": "egc_msk_2023", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 24.93, "width": 21.7, "reference": 46.63, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 61, "tested": 436, "frequency": 13.99, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "KMT2C", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 60, "tested": 436, "frequency": 13.76, "cohort_count": 3, "frequency_range": {"min": 5.32, "max": 13.76}, "major_variants": ["F4496Lfs*21 (n=6)", "R2066* (n=2)", "E1097del (n=2)", "S143Vfs*3 (n=2)", "R56* (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_tcga_pan_can_atlas_2018", "source_record_id": "stad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Gastric Cancer (OncoSG, 2018)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_oncosg_2018", "source_record_id": "stad_oncosg_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=egc_msk_2023", "source_record_id": "egc_msk_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Stomach Adenocarcinoma (TCGA, PanCancer Atlas), 60/436 patients (13.76%).", "Without the 41 hypermutated patients: 39/395 (9.87%).", "Observed in 3 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "stad_tcga_pan_can_atlas_2018", "cohort_name": "Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 60, "tested": 436, "frequency": 13.76, "frequency_excl_hypermutated": 9.87, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "436/440", "coverage_note": null, "source_id": "stad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "stad_oncosg_2018", "cohort_name": "Gastric Cancer (OncoSG, 2018)", "altered": 15, "tested": 147, "frequency": 10.2, "frequency_excl_hypermutated": 6.43, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "147/147", "coverage_note": null, "source_id": "stad_oncosg_2018", "is_reference": false}, {"cohort": "egc_msk_2023", "cohort_name": "Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "altered": 48, "tested": 902, "frequency": 5.32, "frequency_excl_hypermutated": 5.23, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "902/902", "coverage_note": null, "source_id": "egc_msk_2023", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 17.73, "width": 28.14, "reference": 45.87, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 60, "tested": 436, "frequency": 13.76, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "FAT2", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 58, "tested": 436, "frequency": 13.3, "cohort_count": 2, "frequency_range": {"min": 4.08, "max": 13.3}, "major_variants": ["R2728W (n=3)", "R1937Q (n=2)", "A3035T (n=1)", "A63T (n=1)", "R3785W (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_tcga_pan_can_atlas_2018", "source_record_id": "stad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Gastric Cancer (OncoSG, 2018)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_oncosg_2018", "source_record_id": "stad_oncosg_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=egc_msk_2023", "source_record_id": "egc_msk_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Stomach Adenocarcinoma (TCGA, PanCancer Atlas), 58/436 patients (13.3%).", "Without the 41 hypermutated patients: 37/395 (9.37%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "stad_tcga_pan_can_atlas_2018", "cohort_name": "Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 58, "tested": 436, "frequency": 13.3, "frequency_excl_hypermutated": 9.37, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "436/440", "coverage_note": null, "source_id": "stad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "stad_oncosg_2018", "cohort_name": "Gastric Cancer (OncoSG, 2018)", "altered": 6, "tested": 147, "frequency": 4.08, "frequency_excl_hypermutated": 2.14, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "147/147", "coverage_note": null, "source_id": "stad_oncosg_2018", "is_reference": false}, {"cohort": "egc_msk_2023", "cohort_name": "Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "902/902", "coverage_note": null, "source_id": "egc_msk_2023", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 13.6, "width": 30.73, "reference": 44.33, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 58, "tested": 436, "frequency": 13.3, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "NBEA", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 56, "tested": 436, "frequency": 12.84, "cohort_count": 2, "frequency_range": {"min": 10.88, "max": 12.84}, "major_variants": ["N1121Mfs*9 (n=4)", "V2250Lfs*10 (n=3)", "V2250Sfs*4 (n=3)", "R2845* (n=2)", "X2102_splice (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_tcga_pan_can_atlas_2018", "source_record_id": "stad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Gastric Cancer (OncoSG, 2018)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_oncosg_2018", "source_record_id": "stad_oncosg_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=egc_msk_2023", "source_record_id": "egc_msk_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Stomach Adenocarcinoma (TCGA, PanCancer Atlas), 56/436 patients (12.84%).", "Without the 41 hypermutated patients: 41/395 (10.38%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "stad_tcga_pan_can_atlas_2018", "cohort_name": "Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 56, "tested": 436, "frequency": 12.84, "frequency_excl_hypermutated": 10.38, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "436/440", "coverage_note": null, "source_id": "stad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "stad_oncosg_2018", "cohort_name": "Gastric Cancer (OncoSG, 2018)", "altered": 16, "tested": 147, "frequency": 10.88, "frequency_excl_hypermutated": 7.86, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "147/147", "coverage_note": null, "source_id": "stad_oncosg_2018", "is_reference": false}, {"cohort": "egc_msk_2023", "cohort_name": "Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "902/902", "coverage_note": null, "source_id": "egc_msk_2023", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 36.27, "width": 6.53, "reference": 42.8, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 56, "tested": 436, "frequency": 12.84, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "TG", "alteration_types": ["SNV / small indel", "amplification"], "altered": 55, "tested": 436, "frequency": 12.61, "cohort_count": 2, "frequency_range": {"min": 6.12, "max": 12.61}, "major_variants": ["W2685Gfs*26 (n=3)", "R1398C (n=2)", "E1770G (n=1)", "R445* (n=1)", "R668C (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_tcga_pan_can_atlas_2018", "source_record_id": "stad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Gastric Cancer (OncoSG, 2018)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_oncosg_2018", "source_record_id": "stad_oncosg_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=egc_msk_2023", "source_record_id": "egc_msk_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Stomach Adenocarcinoma (TCGA, PanCancer Atlas), 55/436 patients (12.61%).", "Without the 41 hypermutated patients: 31/395 (7.85%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "stad_tcga_pan_can_atlas_2018", "cohort_name": "Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 55, "tested": 436, "frequency": 12.61, "frequency_excl_hypermutated": 7.85, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "436/440", "coverage_note": null, "source_id": "stad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "stad_oncosg_2018", "cohort_name": "Gastric Cancer (OncoSG, 2018)", "altered": 9, "tested": 147, "frequency": 6.12, "frequency_excl_hypermutated": 4.29, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "147/147", "coverage_note": null, "source_id": "stad_oncosg_2018", "is_reference": false}, {"cohort": "egc_msk_2023", "cohort_name": "Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "902/902", "coverage_note": null, "source_id": "egc_msk_2023", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 20.4, "width": 21.63, "reference": 42.03, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 55, "tested": 436, "frequency": 12.61, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "SDK1", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 54, "tested": 436, "frequency": 12.39, "cohort_count": 2, "frequency_range": {"min": 8.84, "max": 12.39}, "major_variants": ["A1984V (n=2)", "A541V (n=2)", "S326I (n=1)", "V1692M (n=1)", "I155V (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_tcga_pan_can_atlas_2018", "source_record_id": "stad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Gastric Cancer (OncoSG, 2018)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_oncosg_2018", "source_record_id": "stad_oncosg_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=egc_msk_2023", "source_record_id": "egc_msk_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Stomach Adenocarcinoma (TCGA, PanCancer Atlas), 54/436 patients (12.39%).", "Without the 41 hypermutated patients: 36/395 (9.11%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "stad_tcga_pan_can_atlas_2018", "cohort_name": "Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 54, "tested": 436, "frequency": 12.39, "frequency_excl_hypermutated": 9.11, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "436/440", "coverage_note": null, "source_id": "stad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "stad_oncosg_2018", "cohort_name": "Gastric Cancer (OncoSG, 2018)", "altered": 13, "tested": 147, "frequency": 8.84, "frequency_excl_hypermutated": 8.57, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "147/147", "coverage_note": null, "source_id": "stad_oncosg_2018", "is_reference": false}, {"cohort": "egc_msk_2023", "cohort_name": "Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "902/902", "coverage_note": null, "source_id": "egc_msk_2023", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 29.47, "width": 11.83, "reference": 41.3, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 54, "tested": 436, "frequency": 12.39, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "RNF213", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 54, "tested": 436, "frequency": 12.39, "cohort_count": 2, "frequency_range": {"min": 6.12, "max": 12.39}, "major_variants": ["R4317Q (n=2)", "X4251_splice (n=1)", "D2027N (n=1)", "T4553M (n=1)", "A530T (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_tcga_pan_can_atlas_2018", "source_record_id": "stad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Gastric Cancer (OncoSG, 2018)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_oncosg_2018", "source_record_id": "stad_oncosg_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=egc_msk_2023", "source_record_id": "egc_msk_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Stomach Adenocarcinoma (TCGA, PanCancer Atlas), 54/436 patients (12.39%).", "Without the 41 hypermutated patients: 23/395 (5.82%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "stad_tcga_pan_can_atlas_2018", "cohort_name": "Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 54, "tested": 436, "frequency": 12.39, "frequency_excl_hypermutated": 5.82, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "436/440", "coverage_note": null, "source_id": "stad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "stad_oncosg_2018", "cohort_name": "Gastric Cancer (OncoSG, 2018)", "altered": 9, "tested": 147, "frequency": 6.12, "frequency_excl_hypermutated": 4.29, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "147/147", "coverage_note": null, "source_id": "stad_oncosg_2018", "is_reference": false}, {"cohort": "egc_msk_2023", "cohort_name": "Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "902/902", "coverage_note": null, "source_id": "egc_msk_2023", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 20.4, "width": 20.9, "reference": 41.3, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 54, "tested": 436, "frequency": 12.39, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "PCDH10", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 54, "tested": 436, "frequency": 12.39, "cohort_count": 2, "frequency_range": {"min": 7.48, "max": 12.39}, "major_variants": ["R529H (n=2)", "G688R (n=1)", "Q227Pfs*19 (n=1)", "A340V (n=1)", "V857I (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_tcga_pan_can_atlas_2018", "source_record_id": "stad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Gastric Cancer (OncoSG, 2018)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_oncosg_2018", "source_record_id": "stad_oncosg_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=egc_msk_2023", "source_record_id": "egc_msk_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Stomach Adenocarcinoma (TCGA, PanCancer Atlas), 54/436 patients (12.39%).", "Without the 41 hypermutated patients: 34/395 (8.61%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "stad_tcga_pan_can_atlas_2018", "cohort_name": "Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 54, "tested": 436, "frequency": 12.39, "frequency_excl_hypermutated": 8.61, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "436/440", "coverage_note": null, "source_id": "stad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "stad_oncosg_2018", "cohort_name": "Gastric Cancer (OncoSG, 2018)", "altered": 11, "tested": 147, "frequency": 7.48, "frequency_excl_hypermutated": 6.43, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "147/147", "coverage_note": null, "source_id": "stad_oncosg_2018", "is_reference": false}, {"cohort": "egc_msk_2023", "cohort_name": "Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "902/902", "coverage_note": null, "source_id": "egc_msk_2023", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 24.93, "width": 16.37, "reference": 41.3, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 54, "tested": 436, "frequency": 12.39, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "MDN1", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 54, "tested": 436, "frequency": 12.39, "cohort_count": 2, "frequency_range": {"min": 9.52, "max": 12.39}, "major_variants": ["F2691Lfs*7 (n=7)", "G1497Afs*10 (n=2)", "Y1056C (n=1)", "A1905V (n=1)", "W383* (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_tcga_pan_can_atlas_2018", "source_record_id": "stad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Gastric Cancer (OncoSG, 2018)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_oncosg_2018", "source_record_id": "stad_oncosg_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=egc_msk_2023", "source_record_id": "egc_msk_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Stomach Adenocarcinoma (TCGA, PanCancer Atlas), 54/436 patients (12.39%).", "Without the 41 hypermutated patients: 29/395 (7.34%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "stad_tcga_pan_can_atlas_2018", "cohort_name": "Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 54, "tested": 436, "frequency": 12.39, "frequency_excl_hypermutated": 7.34, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "436/440", "coverage_note": null, "source_id": "stad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "stad_oncosg_2018", "cohort_name": "Gastric Cancer (OncoSG, 2018)", "altered": 14, "tested": 147, "frequency": 9.52, "frequency_excl_hypermutated": 5.71, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "147/147", "coverage_note": null, "source_id": "stad_oncosg_2018", "is_reference": false}, {"cohort": "egc_msk_2023", "cohort_name": "Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "902/902", "coverage_note": null, "source_id": "egc_msk_2023", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 31.73, "width": 9.57, "reference": 41.3, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 54, "tested": 436, "frequency": 12.39, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "GLI3", "alteration_types": ["SNV / small indel", "amplification"], "altered": 54, "tested": 436, "frequency": 12.39, "cohort_count": 2, "frequency_range": {"min": 8.16, "max": 12.39}, "major_variants": ["P1033Rfs*46 (n=6)", "T263M (n=1)", "G633V (n=1)", "S1166I (n=1)", "Q451Sfs*51 (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_tcga_pan_can_atlas_2018", "source_record_id": "stad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Gastric Cancer (OncoSG, 2018)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_oncosg_2018", "source_record_id": "stad_oncosg_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=egc_msk_2023", "source_record_id": "egc_msk_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Stomach Adenocarcinoma (TCGA, PanCancer Atlas), 54/436 patients (12.39%).", "Without the 41 hypermutated patients: 32/395 (8.1%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "stad_tcga_pan_can_atlas_2018", "cohort_name": "Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 54, "tested": 436, "frequency": 12.39, "frequency_excl_hypermutated": 8.1, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "436/440", "coverage_note": null, "source_id": "stad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "stad_oncosg_2018", "cohort_name": "Gastric Cancer (OncoSG, 2018)", "altered": 12, "tested": 147, "frequency": 8.16, "frequency_excl_hypermutated": 7.14, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "147/147", "coverage_note": null, "source_id": "stad_oncosg_2018", "is_reference": false}, {"cohort": "egc_msk_2023", "cohort_name": "Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "902/902", "coverage_note": null, "source_id": "egc_msk_2023", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 27.2, "width": 14.1, "reference": 41.3, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 54, "tested": 436, "frequency": 12.39, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "PREX2", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 53, "tested": 436, "frequency": 12.16, "cohort_count": 3, "frequency_range": {"min": 7.48, "max": 12.16}, "major_variants": ["S285N (n=2)", "L50V (n=2)", "T706S (n=2)", "E68G (n=1)", "F885C (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_tcga_pan_can_atlas_2018", "source_record_id": "stad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Gastric Cancer (OncoSG, 2018)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_oncosg_2018", "source_record_id": "stad_oncosg_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=egc_msk_2023", "source_record_id": "egc_msk_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Stomach Adenocarcinoma (TCGA, PanCancer Atlas), 53/436 patients (12.16%).", "Without the 41 hypermutated patients: 38/395 (9.62%).", "Observed in 3 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "stad_tcga_pan_can_atlas_2018", "cohort_name": "Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 53, "tested": 436, "frequency": 12.16, "frequency_excl_hypermutated": 9.62, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "436/440", "coverage_note": null, "source_id": "stad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "stad_oncosg_2018", "cohort_name": "Gastric Cancer (OncoSG, 2018)", "altered": 11, "tested": 147, "frequency": 7.48, "frequency_excl_hypermutated": 6.43, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "147/147", "coverage_note": null, "source_id": "stad_oncosg_2018", "is_reference": false}, {"cohort": "egc_msk_2023", "cohort_name": "Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "altered": 59, "tested": 631, "frequency": 9.35, "frequency_excl_hypermutated": 9.09, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "902/902", "coverage_note": null, "source_id": "egc_msk_2023", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 24.93, "width": 15.6, "reference": 40.53, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 53, "tested": 436, "frequency": 12.16, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "PXDN", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 52, "tested": 436, "frequency": 11.93, "cohort_count": 2, "frequency_range": {"min": 5.44, "max": 11.93}, "major_variants": ["N865Mfs*25 (n=8)", "T1046M (n=2)", "L296V (n=2)", "T805M (n=2)", "T360M (n=2)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_tcga_pan_can_atlas_2018", "source_record_id": "stad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Gastric Cancer (OncoSG, 2018)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_oncosg_2018", "source_record_id": "stad_oncosg_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=egc_msk_2023", "source_record_id": "egc_msk_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Stomach Adenocarcinoma (TCGA, PanCancer Atlas), 52/436 patients (11.93%).", "Without the 41 hypermutated patients: 31/395 (7.85%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "stad_tcga_pan_can_atlas_2018", "cohort_name": "Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 52, "tested": 436, "frequency": 11.93, "frequency_excl_hypermutated": 7.85, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "436/440", "coverage_note": null, "source_id": "stad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "stad_oncosg_2018", "cohort_name": "Gastric Cancer (OncoSG, 2018)", "altered": 8, "tested": 147, "frequency": 5.44, "frequency_excl_hypermutated": 5.71, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "147/147", "coverage_note": null, "source_id": "stad_oncosg_2018", "is_reference": false}, {"cohort": "egc_msk_2023", "cohort_name": "Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "902/902", "coverage_note": null, "source_id": "egc_msk_2023", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 18.13, "width": 21.64, "reference": 39.77, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 52, "tested": 436, "frequency": 11.93, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "PTPRT", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 52, "tested": 436, "frequency": 11.93, "cohort_count": 3, "frequency_range": {"min": 5.44, "max": 11.93}, "major_variants": ["P1094Rfs*6 (n=5)", "F1302L (n=1)", "E1296V (n=1)", "N40S (n=1)", "R416C (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_tcga_pan_can_atlas_2018", "source_record_id": "stad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Gastric Cancer (OncoSG, 2018)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_oncosg_2018", "source_record_id": "stad_oncosg_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=egc_msk_2023", "source_record_id": "egc_msk_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Stomach Adenocarcinoma (TCGA, PanCancer Atlas), 52/436 patients (11.93%).", "Without the 41 hypermutated patients: 35/395 (8.86%).", "Observed in 3 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "stad_tcga_pan_can_atlas_2018", "cohort_name": "Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 52, "tested": 436, "frequency": 11.93, "frequency_excl_hypermutated": 8.86, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "436/440", "coverage_note": null, "source_id": "stad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "stad_oncosg_2018", "cohort_name": "Gastric Cancer (OncoSG, 2018)", "altered": 8, "tested": 147, "frequency": 5.44, "frequency_excl_hypermutated": 4.29, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "147/147", "coverage_note": null, "source_id": "stad_oncosg_2018", "is_reference": false}, {"cohort": "egc_msk_2023", "cohort_name": "Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "altered": 61, "tested": 902, "frequency": 6.76, "frequency_excl_hypermutated": 6.57, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "902/902", "coverage_note": null, "source_id": "egc_msk_2023", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 18.13, "width": 21.64, "reference": 39.77, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 52, "tested": 436, "frequency": 11.93, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "ERBB4", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 52, "tested": 436, "frequency": 11.93, "cohort_count": 3, "frequency_range": {"min": 4.08, "max": 11.93}, "major_variants": ["M1? (n=3)", "F1102C (n=2)", "R50C (n=2)", "N1177Mfs*27 (n=2)", "F401S (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_tcga_pan_can_atlas_2018", "source_record_id": "stad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Gastric Cancer (OncoSG, 2018)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_oncosg_2018", "source_record_id": "stad_oncosg_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=egc_msk_2023", "source_record_id": "egc_msk_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Stomach Adenocarcinoma (TCGA, PanCancer Atlas), 52/436 patients (11.93%).", "Without the 41 hypermutated patients: 40/395 (10.13%).", "Observed in 3 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "stad_tcga_pan_can_atlas_2018", "cohort_name": "Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 52, "tested": 436, "frequency": 11.93, "frequency_excl_hypermutated": 10.13, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "436/440", "coverage_note": null, "source_id": "stad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "stad_oncosg_2018", "cohort_name": "Gastric Cancer (OncoSG, 2018)", "altered": 6, "tested": 147, "frequency": 4.08, "frequency_excl_hypermutated": 3.57, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "147/147", "coverage_note": null, "source_id": "stad_oncosg_2018", "is_reference": false}, {"cohort": "egc_msk_2023", "cohort_name": "Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "altered": 53, "tested": 902, "frequency": 5.88, "frequency_excl_hypermutated": 5.68, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "902/902", "coverage_note": null, "source_id": "egc_msk_2023", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 13.6, "width": 26.17, "reference": 39.77, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 52, "tested": 436, "frequency": 11.93, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "CMYA5", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 52, "tested": 436, "frequency": 11.93, "cohort_count": 2, "frequency_range": {"min": 2.72, "max": 11.93}, "major_variants": ["E1984D (n=2)", "E2293Kfs*9 (n=2)", "L2460F (n=1)", "P793L (n=1)", "N3464H (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_tcga_pan_can_atlas_2018", "source_record_id": "stad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Gastric Cancer (OncoSG, 2018)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_oncosg_2018", "source_record_id": "stad_oncosg_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=egc_msk_2023", "source_record_id": "egc_msk_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Stomach Adenocarcinoma (TCGA, PanCancer Atlas), 52/436 patients (11.93%).", "Without the 41 hypermutated patients: 36/395 (9.11%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "stad_tcga_pan_can_atlas_2018", "cohort_name": "Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 52, "tested": 436, "frequency": 11.93, "frequency_excl_hypermutated": 9.11, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "436/440", "coverage_note": null, "source_id": "stad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "stad_oncosg_2018", "cohort_name": "Gastric Cancer (OncoSG, 2018)", "altered": 4, "tested": 147, "frequency": 2.72, "frequency_excl_hypermutated": 2.14, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "147/147", "coverage_note": null, "source_id": "stad_oncosg_2018", "is_reference": false}, {"cohort": "egc_msk_2023", "cohort_name": "Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "902/902", "coverage_note": null, "source_id": "egc_msk_2023", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 9.07, "width": 30.7, "reference": 39.77, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 52, "tested": 436, "frequency": 11.93, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "CDH23", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 52, "tested": 436, "frequency": 11.93, "cohort_count": 2, "frequency_range": {"min": 4.08, "max": 11.93}, "major_variants": ["V410I (n=3)", "A1897V (n=2)", "A3149T (n=1)", "A1294T (n=1)", "R969W (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_tcga_pan_can_atlas_2018", "source_record_id": "stad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Gastric Cancer (OncoSG, 2018)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_oncosg_2018", "source_record_id": "stad_oncosg_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=egc_msk_2023", "source_record_id": "egc_msk_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Stomach Adenocarcinoma (TCGA, PanCancer Atlas), 52/436 patients (11.93%).", "Without the 41 hypermutated patients: 31/395 (7.85%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "stad_tcga_pan_can_atlas_2018", "cohort_name": "Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 52, "tested": 436, "frequency": 11.93, "frequency_excl_hypermutated": 7.85, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "436/440", "coverage_note": null, "source_id": "stad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "stad_oncosg_2018", "cohort_name": "Gastric Cancer (OncoSG, 2018)", "altered": 6, "tested": 147, "frequency": 4.08, "frequency_excl_hypermutated": 2.86, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "147/147", "coverage_note": null, "source_id": "stad_oncosg_2018", "is_reference": false}, {"cohort": "egc_msk_2023", "cohort_name": "Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "902/902", "coverage_note": null, "source_id": "egc_msk_2023", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 13.6, "width": 26.17, "reference": 39.77, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 52, "tested": 436, "frequency": 11.93, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "VPS13B", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 51, "tested": 436, "frequency": 11.7, "cohort_count": 2, "frequency_range": {"min": 3.4, "max": 11.7}, "major_variants": ["L58* (n=5)", "V2481I (n=2)", "R215W (n=2)", "E3318G (n=1)", "I3515V (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_tcga_pan_can_atlas_2018", "source_record_id": "stad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Gastric Cancer (OncoSG, 2018)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_oncosg_2018", "source_record_id": "stad_oncosg_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=egc_msk_2023", "source_record_id": "egc_msk_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Stomach Adenocarcinoma (TCGA, PanCancer Atlas), 51/436 patients (11.7%).", "Without the 41 hypermutated patients: 28/395 (7.09%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "stad_tcga_pan_can_atlas_2018", "cohort_name": "Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 51, "tested": 436, "frequency": 11.7, "frequency_excl_hypermutated": 7.09, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "436/440", "coverage_note": null, "source_id": "stad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "stad_oncosg_2018", "cohort_name": "Gastric Cancer (OncoSG, 2018)", "altered": 5, "tested": 147, "frequency": 3.4, "frequency_excl_hypermutated": 2.86, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "147/147", "coverage_note": null, "source_id": "stad_oncosg_2018", "is_reference": false}, {"cohort": "egc_msk_2023", "cohort_name": "Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "902/902", "coverage_note": null, "source_id": "egc_msk_2023", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 11.33, "width": 27.67, "reference": 39.0, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 51, "tested": 436, "frequency": 11.7, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "PLXNA4", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 51, "tested": 436, "frequency": 11.7, "cohort_count": 2, "frequency_range": {"min": 4.76, "max": 11.7}, "major_variants": ["Y573N (n=1)", "D1718V (n=1)", "A186V (n=1)", "L204R (n=1)", "R1323W (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_tcga_pan_can_atlas_2018", "source_record_id": "stad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Gastric Cancer (OncoSG, 2018)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_oncosg_2018", "source_record_id": "stad_oncosg_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=egc_msk_2023", "source_record_id": "egc_msk_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Stomach Adenocarcinoma (TCGA, PanCancer Atlas), 51/436 patients (11.7%).", "Without the 41 hypermutated patients: 35/395 (8.86%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "stad_tcga_pan_can_atlas_2018", "cohort_name": "Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 51, "tested": 436, "frequency": 11.7, "frequency_excl_hypermutated": 8.86, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "436/440", "coverage_note": null, "source_id": "stad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "stad_oncosg_2018", "cohort_name": "Gastric Cancer (OncoSG, 2018)", "altered": 7, "tested": 147, "frequency": 4.76, "frequency_excl_hypermutated": 3.57, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "147/147", "coverage_note": null, "source_id": "stad_oncosg_2018", "is_reference": false}, {"cohort": "egc_msk_2023", "cohort_name": "Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "902/902", "coverage_note": null, "source_id": "egc_msk_2023", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 15.87, "width": 23.13, "reference": 39.0, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 51, "tested": 436, "frequency": 11.7, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "NAV3", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 51, "tested": 436, "frequency": 11.7, "cohort_count": 2, "frequency_range": {"min": 8.16, "max": 11.7}, "major_variants": ["K498Rfs*8 (n=2)", "A2066E (n=1)", "D810G (n=1)", "R1959C (n=1)", "L2069R (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_tcga_pan_can_atlas_2018", "source_record_id": "stad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Gastric Cancer (OncoSG, 2018)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_oncosg_2018", "source_record_id": "stad_oncosg_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=egc_msk_2023", "source_record_id": "egc_msk_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Stomach Adenocarcinoma (TCGA, PanCancer Atlas), 51/436 patients (11.7%).", "Without the 41 hypermutated patients: 34/395 (8.61%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "stad_tcga_pan_can_atlas_2018", "cohort_name": "Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 51, "tested": 436, "frequency": 11.7, "frequency_excl_hypermutated": 8.61, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "436/440", "coverage_note": null, "source_id": "stad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "stad_oncosg_2018", "cohort_name": "Gastric Cancer (OncoSG, 2018)", "altered": 12, "tested": 147, "frequency": 8.16, "frequency_excl_hypermutated": 6.43, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "147/147", "coverage_note": null, "source_id": "stad_oncosg_2018", "is_reference": false}, {"cohort": "egc_msk_2023", "cohort_name": "Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "902/902", "coverage_note": null, "source_id": "egc_msk_2023", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 27.2, "width": 11.8, "reference": 39.0, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 51, "tested": 436, "frequency": 11.7, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "DOCK3", "alteration_types": ["SNV / small indel", "deep deletion", "amplification"], "altered": 51, "tested": 436, "frequency": 11.7, "cohort_count": 2, "frequency_range": {"min": 4.76, "max": 11.7}, "major_variants": ["P1852Qfs*45 (n=28)", "P1852Sfs*46 (n=5)", "G153Vfs*17 (n=1)", "S84Y (n=1)", "G1834Vfs*63 (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_tcga_pan_can_atlas_2018", "source_record_id": "stad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Gastric Cancer (OncoSG, 2018)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_oncosg_2018", "source_record_id": "stad_oncosg_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=egc_msk_2023", "source_record_id": "egc_msk_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Stomach Adenocarcinoma (TCGA, PanCancer Atlas), 51/436 patients (11.7%).", "Without the 41 hypermutated patients: 21/395 (5.32%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "stad_tcga_pan_can_atlas_2018", "cohort_name": "Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 51, "tested": 436, "frequency": 11.7, "frequency_excl_hypermutated": 5.32, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "436/440", "coverage_note": null, "source_id": "stad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "stad_oncosg_2018", "cohort_name": "Gastric Cancer (OncoSG, 2018)", "altered": 7, "tested": 147, "frequency": 4.76, "frequency_excl_hypermutated": 3.57, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "147/147", "coverage_note": null, "source_id": "stad_oncosg_2018", "is_reference": false}, {"cohort": "egc_msk_2023", "cohort_name": "Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "902/902", "coverage_note": null, "source_id": "egc_msk_2023", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 15.87, "width": 23.13, "reference": 39.0, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 51, "tested": 436, "frequency": 11.7, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "APC", "alteration_types": ["SNV / small indel", "deep deletion"], "altered": 51, "tested": 436, "frequency": 11.7, "cohort_count": 3, "frequency_range": {"min": 6.8, "max": 11.7}, "major_variants": ["R2204* (n=3)", "T1556Nfs*3 (n=3)", "R259W (n=2)", "R302* (n=2)", "R1450* (n=2)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_tcga_pan_can_atlas_2018", "source_record_id": "stad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Gastric Cancer (OncoSG, 2018)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_oncosg_2018", "source_record_id": "stad_oncosg_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=egc_msk_2023", "source_record_id": "egc_msk_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Stomach Adenocarcinoma (TCGA, PanCancer Atlas), 51/436 patients (11.7%).", "Without the 41 hypermutated patients: 37/395 (9.37%).", "Observed in 3 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "stad_tcga_pan_can_atlas_2018", "cohort_name": "Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 51, "tested": 436, "frequency": 11.7, "frequency_excl_hypermutated": 9.37, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "436/440", "coverage_note": null, "source_id": "stad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "stad_oncosg_2018", "cohort_name": "Gastric Cancer (OncoSG, 2018)", "altered": 10, "tested": 147, "frequency": 6.8, "frequency_excl_hypermutated": 5.71, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "147/147", "coverage_note": null, "source_id": "stad_oncosg_2018", "is_reference": false}, {"cohort": "egc_msk_2023", "cohort_name": "Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "altered": 62, "tested": 902, "frequency": 6.87, "frequency_excl_hypermutated": 6.46, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "902/902", "coverage_note": null, "source_id": "egc_msk_2023", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 22.67, "width": 16.33, "reference": 39.0, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 51, "tested": 436, "frequency": 11.7, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "ACVR2A", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 50, "tested": 436, "frequency": 11.47, "cohort_count": 2, "frequency_range": {"min": 7.48, "max": 11.47}, "major_variants": ["K437Rfs*5 (n=31)", "D96Tfs*54 (n=6)", "K437Efs*19 (n=3)", "C85G (n=1)", "G256D (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_tcga_pan_can_atlas_2018", "source_record_id": "stad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Gastric Cancer (OncoSG, 2018)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_oncosg_2018", "source_record_id": "stad_oncosg_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=egc_msk_2023", "source_record_id": "egc_msk_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Stomach Adenocarcinoma (TCGA, PanCancer Atlas), 50/436 patients (11.47%).", "Without the 41 hypermutated patients: 29/395 (7.34%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "stad_tcga_pan_can_atlas_2018", "cohort_name": "Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 50, "tested": 436, "frequency": 11.47, "frequency_excl_hypermutated": 7.34, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "436/440", "coverage_note": null, "source_id": "stad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "stad_oncosg_2018", "cohort_name": "Gastric Cancer (OncoSG, 2018)", "altered": 11, "tested": 147, "frequency": 7.48, "frequency_excl_hypermutated": 3.57, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "147/147", "coverage_note": null, "source_id": "stad_oncosg_2018", "is_reference": false}, {"cohort": "egc_msk_2023", "cohort_name": "Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "902/902", "coverage_note": null, "source_id": "egc_msk_2023", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 24.93, "width": 13.3, "reference": 38.23, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 50, "tested": 436, "frequency": 11.47, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "TRRAP", "alteration_types": ["SNV / small indel", "amplification"], "altered": 49, "tested": 436, "frequency": 11.24, "cohort_count": 2, "frequency_range": {"min": 6.12, "max": 11.24}, "major_variants": ["R107H (n=2)", "R2549W (n=1)", "V1161Cfs*5 (n=1)", "A973V (n=1)", "R1170W (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_tcga_pan_can_atlas_2018", "source_record_id": "stad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Gastric Cancer (OncoSG, 2018)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_oncosg_2018", "source_record_id": "stad_oncosg_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=egc_msk_2023", "source_record_id": "egc_msk_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Stomach Adenocarcinoma (TCGA, PanCancer Atlas), 49/436 patients (11.24%).", "Without the 41 hypermutated patients: 28/395 (7.09%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "stad_tcga_pan_can_atlas_2018", "cohort_name": "Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 49, "tested": 436, "frequency": 11.24, "frequency_excl_hypermutated": 7.09, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "436/440", "coverage_note": null, "source_id": "stad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "stad_oncosg_2018", "cohort_name": "Gastric Cancer (OncoSG, 2018)", "altered": 9, "tested": 147, "frequency": 6.12, "frequency_excl_hypermutated": 4.29, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "147/147", "coverage_note": null, "source_id": "stad_oncosg_2018", "is_reference": false}, {"cohort": "egc_msk_2023", "cohort_name": "Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "902/902", "coverage_note": null, "source_id": "egc_msk_2023", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 20.4, "width": 17.07, "reference": 37.47, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 49, "tested": 436, "frequency": 11.24, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "ABCA12", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 49, "tested": 436, "frequency": 11.24, "cohort_count": 2, "frequency_range": {"min": 4.08, "max": 11.24}, "major_variants": ["N1671Ifs*4 (n=9)", "V498* (n=2)", "I2143N (n=1)", "R714Q (n=1)", "S1998F (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_tcga_pan_can_atlas_2018", "source_record_id": "stad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Gastric Cancer (OncoSG, 2018)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_oncosg_2018", "source_record_id": "stad_oncosg_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=egc_msk_2023", "source_record_id": "egc_msk_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Stomach Adenocarcinoma (TCGA, PanCancer Atlas), 49/436 patients (11.24%).", "Without the 41 hypermutated patients: 33/395 (8.35%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "stad_tcga_pan_can_atlas_2018", "cohort_name": "Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 49, "tested": 436, "frequency": 11.24, "frequency_excl_hypermutated": 8.35, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "436/440", "coverage_note": null, "source_id": "stad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "stad_oncosg_2018", "cohort_name": "Gastric Cancer (OncoSG, 2018)", "altered": 6, "tested": 147, "frequency": 4.08, "frequency_excl_hypermutated": 2.14, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "147/147", "coverage_note": null, "source_id": "stad_oncosg_2018", "is_reference": false}, {"cohort": "egc_msk_2023", "cohort_name": "Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "902/902", "coverage_note": null, "source_id": "egc_msk_2023", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 13.6, "width": 23.87, "reference": 37.47, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 49, "tested": 436, "frequency": 11.24, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "RIMS2", "alteration_types": ["SNV / small indel", "amplification"], "altered": 48, "tested": 436, "frequency": 11.01, "cohort_count": 2, "frequency_range": {"min": 10.2, "max": 11.01}, "major_variants": ["L448V (n=5)", "G626Efs*3 (n=3)", "M474Wfs*5 (n=2)", "R455Q (n=2)", "S422R (n=2)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_tcga_pan_can_atlas_2018", "source_record_id": "stad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Gastric Cancer (OncoSG, 2018)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_oncosg_2018", "source_record_id": "stad_oncosg_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=egc_msk_2023", "source_record_id": "egc_msk_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Stomach Adenocarcinoma (TCGA, PanCancer Atlas), 48/436 patients (11.01%).", "Without the 41 hypermutated patients: 31/395 (7.85%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "stad_tcga_pan_can_atlas_2018", "cohort_name": "Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 48, "tested": 436, "frequency": 11.01, "frequency_excl_hypermutated": 7.85, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "436/440", "coverage_note": null, "source_id": "stad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "stad_oncosg_2018", "cohort_name": "Gastric Cancer (OncoSG, 2018)", "altered": 15, "tested": 147, "frequency": 10.2, "frequency_excl_hypermutated": 9.29, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "147/147", "coverage_note": null, "source_id": "stad_oncosg_2018", "is_reference": false}, {"cohort": "egc_msk_2023", "cohort_name": "Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "902/902", "coverage_note": null, "source_id": "egc_msk_2023", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 34.0, "width": 2.7, "reference": 36.7, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 48, "tested": 436, "frequency": 11.01, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "RELN", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 48, "tested": 436, "frequency": 11.01, "cohort_count": 2, "frequency_range": {"min": 6.12, "max": 11.01}, "major_variants": ["R3431H (n=2)", "S2199G (n=1)", "A2937V (n=1)", "E331* (n=1)", "T2469I (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_tcga_pan_can_atlas_2018", "source_record_id": "stad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Gastric Cancer (OncoSG, 2018)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_oncosg_2018", "source_record_id": "stad_oncosg_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=egc_msk_2023", "source_record_id": "egc_msk_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Stomach Adenocarcinoma (TCGA, PanCancer Atlas), 48/436 patients (11.01%).", "Without the 41 hypermutated patients: 31/395 (7.85%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "stad_tcga_pan_can_atlas_2018", "cohort_name": "Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 48, "tested": 436, "frequency": 11.01, "frequency_excl_hypermutated": 7.85, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "436/440", "coverage_note": null, "source_id": "stad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "stad_oncosg_2018", "cohort_name": "Gastric Cancer (OncoSG, 2018)", "altered": 9, "tested": 147, "frequency": 6.12, "frequency_excl_hypermutated": 3.57, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "147/147", "coverage_note": null, "source_id": "stad_oncosg_2018", "is_reference": false}, {"cohort": "egc_msk_2023", "cohort_name": "Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "902/902", "coverage_note": null, "source_id": "egc_msk_2023", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 20.4, "width": 16.3, "reference": 36.7, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 48, "tested": 436, "frequency": 11.01, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "HERC2", "alteration_types": ["SNV / small indel", "amplification"], "altered": 48, "tested": 436, "frequency": 11.01, "cohort_count": 2, "frequency_range": {"min": 4.76, "max": 11.01}, "major_variants": ["R2800H (n=2)", "F1196Lfs*12 (n=2)", "S181Vfs*85 (n=2)", "R3681C (n=1)", "A876V (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_tcga_pan_can_atlas_2018", "source_record_id": "stad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Gastric Cancer (OncoSG, 2018)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_oncosg_2018", "source_record_id": "stad_oncosg_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=egc_msk_2023", "source_record_id": "egc_msk_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Stomach Adenocarcinoma (TCGA, PanCancer Atlas), 48/436 patients (11.01%).", "Without the 41 hypermutated patients: 22/395 (5.57%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "stad_tcga_pan_can_atlas_2018", "cohort_name": "Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 48, "tested": 436, "frequency": 11.01, "frequency_excl_hypermutated": 5.57, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "436/440", "coverage_note": null, "source_id": "stad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "stad_oncosg_2018", "cohort_name": "Gastric Cancer (OncoSG, 2018)", "altered": 7, "tested": 147, "frequency": 4.76, "frequency_excl_hypermutated": 3.57, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "147/147", "coverage_note": null, "source_id": "stad_oncosg_2018", "is_reference": false}, {"cohort": "egc_msk_2023", "cohort_name": "Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "902/902", "coverage_note": null, "source_id": "egc_msk_2023", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 15.87, "width": 20.83, "reference": 36.7, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 48, "tested": 436, "frequency": 11.01, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "COL6A3", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 48, "tested": 436, "frequency": 11.01, "cohort_count": 2, "frequency_range": {"min": 2.72, "max": 11.01}, "major_variants": ["G520S (n=2)", "A2670T (n=2)", "D2615N (n=2)", "D598N (n=2)", "V1251I (n=2)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_tcga_pan_can_atlas_2018", "source_record_id": "stad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Gastric Cancer (OncoSG, 2018)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_oncosg_2018", "source_record_id": "stad_oncosg_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=egc_msk_2023", "source_record_id": "egc_msk_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Stomach Adenocarcinoma (TCGA, PanCancer Atlas), 48/436 patients (11.01%).", "Without the 41 hypermutated patients: 32/395 (8.1%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "stad_tcga_pan_can_atlas_2018", "cohort_name": "Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 48, "tested": 436, "frequency": 11.01, "frequency_excl_hypermutated": 8.1, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "436/440", "coverage_note": null, "source_id": "stad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "stad_oncosg_2018", "cohort_name": "Gastric Cancer (OncoSG, 2018)", "altered": 4, "tested": 147, "frequency": 2.72, "frequency_excl_hypermutated": 0.71, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "147/147", "coverage_note": null, "source_id": "stad_oncosg_2018", "is_reference": false}, {"cohort": "egc_msk_2023", "cohort_name": "Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "902/902", "coverage_note": null, "source_id": "egc_msk_2023", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 9.07, "width": 27.63, "reference": 36.7, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 48, "tested": 436, "frequency": 11.01, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "ADGRB3", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 48, "tested": 436, "frequency": 11.01, "cohort_count": 1, "frequency_range": {"min": 0.0, "max": 11.01}, "major_variants": ["R274Gfs*57 (n=2)", "T481S (n=1)", "P440S (n=1)", "A712S (n=1)", "R334S (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_tcga_pan_can_atlas_2018", "source_record_id": "stad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Gastric Cancer (OncoSG, 2018)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_oncosg_2018", "source_record_id": "stad_oncosg_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=egc_msk_2023", "source_record_id": "egc_msk_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Stomach Adenocarcinoma (TCGA, PanCancer Atlas), 48/436 patients (11.01%).", "Without the 41 hypermutated patients: 35/395 (8.86%).", "Observed in 1 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "stad_tcga_pan_can_atlas_2018", "cohort_name": "Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 48, "tested": 436, "frequency": 11.01, "frequency_excl_hypermutated": 8.86, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "436/440", "coverage_note": null, "source_id": "stad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "stad_oncosg_2018", "cohort_name": "Gastric Cancer (OncoSG, 2018)", "altered": 0, "tested": 147, "frequency": 0.0, "frequency_excl_hypermutated": 0.0, "counting_unit": "patients", "status": "not_observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "147/147", "coverage_note": null, "source_id": "stad_oncosg_2018", "is_reference": false}, {"cohort": "egc_msk_2023", "cohort_name": "Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "902/902", "coverage_note": null, "source_id": "egc_msk_2023", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 0.0, "width": 36.7, "reference": 36.7, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 48, "tested": 436, "frequency": 11.01, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "NALCN", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 47, "tested": 436, "frequency": 10.78, "cohort_count": 2, "frequency_range": {"min": 3.4, "max": 10.78}, "major_variants": ["R1607Q (n=2)", "X860_splice (n=2)", "D1277N (n=1)", "R159Q (n=1)", "K812Rfs*6 (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_tcga_pan_can_atlas_2018", "source_record_id": "stad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Gastric Cancer (OncoSG, 2018)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_oncosg_2018", "source_record_id": "stad_oncosg_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=egc_msk_2023", "source_record_id": "egc_msk_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Stomach Adenocarcinoma (TCGA, PanCancer Atlas), 47/436 patients (10.78%).", "Without the 41 hypermutated patients: 32/395 (8.1%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "stad_tcga_pan_can_atlas_2018", "cohort_name": "Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 47, "tested": 436, "frequency": 10.78, "frequency_excl_hypermutated": 8.1, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "436/440", "coverage_note": null, "source_id": "stad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "stad_oncosg_2018", "cohort_name": "Gastric Cancer (OncoSG, 2018)", "altered": 5, "tested": 147, "frequency": 3.4, "frequency_excl_hypermutated": 3.57, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "147/147", "coverage_note": null, "source_id": "stad_oncosg_2018", "is_reference": false}, {"cohort": "egc_msk_2023", "cohort_name": "Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "902/902", "coverage_note": null, "source_id": "egc_msk_2023", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 11.33, "width": 24.6, "reference": 35.93, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 47, "tested": 436, "frequency": 10.78, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "CACNA1E", "alteration_types": ["SNV / small indel", "amplification"], "altered": 47, "tested": 436, "frequency": 10.78, "cohort_count": 2, "frequency_range": {"min": 6.12, "max": 10.78}, "major_variants": ["R1582H (n=2)", "V1176I (n=2)", "R1594H (n=2)", "A1307T (n=1)", "R1182C (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_tcga_pan_can_atlas_2018", "source_record_id": "stad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Gastric Cancer (OncoSG, 2018)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_oncosg_2018", "source_record_id": "stad_oncosg_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=egc_msk_2023", "source_record_id": "egc_msk_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Stomach Adenocarcinoma (TCGA, PanCancer Atlas), 47/436 patients (10.78%).", "Without the 41 hypermutated patients: 26/395 (6.58%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "stad_tcga_pan_can_atlas_2018", "cohort_name": "Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 47, "tested": 436, "frequency": 10.78, "frequency_excl_hypermutated": 6.58, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "436/440", "coverage_note": null, "source_id": "stad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "stad_oncosg_2018", "cohort_name": "Gastric Cancer (OncoSG, 2018)", "altered": 9, "tested": 147, "frequency": 6.12, "frequency_excl_hypermutated": 3.57, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "147/147", "coverage_note": null, "source_id": "stad_oncosg_2018", "is_reference": false}, {"cohort": "egc_msk_2023", "cohort_name": "Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "902/902", "coverage_note": null, "source_id": "egc_msk_2023", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 20.4, "width": 15.53, "reference": 35.93, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 47, "tested": 436, "frequency": 10.78, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "UBR5", "alteration_types": ["SNV / small indel", "amplification"], "altered": 46, "tested": 436, "frequency": 10.55, "cohort_count": 2, "frequency_range": {"min": 5.44, "max": 10.55}, "major_variants": ["E2121Kfs*28 (n=26)", "R1753C (n=2)", "E2194K (n=1)", "V1437Cfs*65 (n=1)", "T744Nfs*29 (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_tcga_pan_can_atlas_2018", "source_record_id": "stad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Gastric Cancer (OncoSG, 2018)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_oncosg_2018", "source_record_id": "stad_oncosg_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=egc_msk_2023", "source_record_id": "egc_msk_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Stomach Adenocarcinoma (TCGA, PanCancer Atlas), 46/436 patients (10.55%).", "Without the 41 hypermutated patients: 22/395 (5.57%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "stad_tcga_pan_can_atlas_2018", "cohort_name": "Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 46, "tested": 436, "frequency": 10.55, "frequency_excl_hypermutated": 5.57, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "436/440", "coverage_note": null, "source_id": "stad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "stad_oncosg_2018", "cohort_name": "Gastric Cancer (OncoSG, 2018)", "altered": 8, "tested": 147, "frequency": 5.44, "frequency_excl_hypermutated": 2.14, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "147/147", "coverage_note": null, "source_id": "stad_oncosg_2018", "is_reference": false}, {"cohort": "egc_msk_2023", "cohort_name": "Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "902/902", "coverage_note": null, "source_id": "egc_msk_2023", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 18.13, "width": 17.04, "reference": 35.17, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 46, "tested": 436, "frequency": 10.55, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "TCHH", "alteration_types": ["SNV / small indel", "amplification"], "altered": 46, "tested": 436, "frequency": 10.55, "cohort_count": 2, "frequency_range": {"min": 1.36, "max": 10.55}, "major_variants": ["R1766H (n=2)", "R328C (n=2)", "K140T (n=1)", "R68C (n=1)", "D1500N (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_tcga_pan_can_atlas_2018", "source_record_id": "stad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Gastric Cancer (OncoSG, 2018)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_oncosg_2018", "source_record_id": "stad_oncosg_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=egc_msk_2023", "source_record_id": "egc_msk_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Stomach Adenocarcinoma (TCGA, PanCancer Atlas), 46/436 patients (10.55%).", "Without the 41 hypermutated patients: 31/395 (7.85%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "stad_tcga_pan_can_atlas_2018", "cohort_name": "Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 46, "tested": 436, "frequency": 10.55, "frequency_excl_hypermutated": 7.85, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "436/440", "coverage_note": null, "source_id": "stad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "stad_oncosg_2018", "cohort_name": "Gastric Cancer (OncoSG, 2018)", "altered": 2, "tested": 147, "frequency": 1.36, "frequency_excl_hypermutated": 0.71, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "147/147", "coverage_note": null, "source_id": "stad_oncosg_2018", "is_reference": false}, {"cohort": "egc_msk_2023", "cohort_name": "Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "902/902", "coverage_note": null, "source_id": "egc_msk_2023", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 4.53, "width": 30.64, "reference": 35.17, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 46, "tested": 436, "frequency": 10.55, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}], "variants": [], "genomic_events": [{"event_type": "copy_number", "gene": "PTPRT", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "PTPRT amplification", "genomic_coordinate": null, "observed": 34, "observed_status": "observed", "observed_unit": "patients", "tested": 108, "tested_status": "observed", "tested_unit": "patients", "frequency": 31.48, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["stad_oncosg_2018"], "source_ids": ["stad_oncosg_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "TG", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "TG amplification", "genomic_coordinate": null, "observed": 29, "observed_status": "observed", "observed_unit": "patients", "tested": 108, "tested_status": "observed", "tested_unit": "patients", "frequency": 26.85, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["stad_oncosg_2018"], "source_ids": ["stad_oncosg_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "VPS13B", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "VPS13B amplification", "genomic_coordinate": null, "observed": 29, "observed_status": "observed", "observed_unit": "patients", "tested": 108, "tested_status": "observed", "tested_unit": "patients", "frequency": 26.85, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["stad_oncosg_2018"], "source_ids": ["stad_oncosg_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "RIMS2", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "RIMS2 amplification", "genomic_coordinate": null, "observed": 28, "observed_status": "observed", "observed_unit": "patients", "tested": 108, "tested_status": "observed", "tested_unit": "patients", "frequency": 25.93, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["stad_oncosg_2018"], "source_ids": ["stad_oncosg_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "UBR5", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "UBR5 amplification", "genomic_coordinate": null, "observed": 25, "observed_status": "observed", "observed_unit": "patients", "tested": 108, "tested_status": "observed", "tested_unit": "patients", "frequency": 23.15, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["stad_oncosg_2018"], "source_ids": ["stad_oncosg_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "CACNA1E", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "CACNA1E amplification", "genomic_coordinate": null, "observed": 18, "observed_status": "observed", "observed_unit": "patients", "tested": 108, "tested_status": "observed", "tested_unit": "patients", "frequency": 16.67, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["stad_oncosg_2018"], "source_ids": ["stad_oncosg_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "ERBB2", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "ERBB2 amplification", "genomic_coordinate": null, "observed": 17, "observed_status": "observed", "observed_unit": "patients", "tested": 108, "tested_status": "observed", "tested_unit": "patients", "frequency": 15.74, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["stad_oncosg_2018"], "source_ids": ["stad_oncosg_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "ERBB2", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "ERBB2 amplification", "genomic_coordinate": null, "observed": 135, "observed_status": "observed", "observed_unit": "patients", "tested": 902, "tested_status": "observed", "tested_unit": "patients", "frequency": 14.97, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["egc_msk_2023"], "source_ids": ["egc_msk_2023_cna"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "NBEA", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "NBEA amplification", "genomic_coordinate": null, "observed": 16, "observed_status": "observed", "observed_unit": "patients", "tested": 108, "tested_status": "observed", "tested_unit": "patients", "frequency": 14.81, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["stad_oncosg_2018"], "source_ids": ["stad_oncosg_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "PREX2", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "PREX2 amplification", "genomic_coordinate": null, "observed": 16, "observed_status": "observed", "observed_unit": "patients", "tested": 108, "tested_status": "observed", "tested_unit": "patients", "frequency": 14.81, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["stad_oncosg_2018"], "source_ids": ["stad_oncosg_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "NALCN", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "NALCN amplification", "genomic_coordinate": null, "observed": 16, "observed_status": "observed", "observed_unit": "patients", "tested": 108, "tested_status": "observed", "tested_unit": "patients", "frequency": 14.81, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["stad_oncosg_2018"], "source_ids": ["stad_oncosg_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "TCHH", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "TCHH amplification", "genomic_coordinate": null, "observed": 16, "observed_status": "observed", "observed_unit": "patients", "tested": 108, "tested_status": "observed", "tested_unit": "patients", "frequency": 14.81, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["stad_oncosg_2018"], "source_ids": ["stad_oncosg_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "TRRAP", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "TRRAP amplification", "genomic_coordinate": null, "observed": 15, "observed_status": "observed", "observed_unit": "patients", "tested": 108, "tested_status": "observed", "tested_unit": "patients", "frequency": 13.89, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["stad_oncosg_2018"], "source_ids": ["stad_oncosg_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "ERBB2", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "ERBB2 amplification", "genomic_coordinate": null, "observed": 58, "observed_status": "observed", "observed_unit": "patients", "tested": 438, "tested_status": "observed", "tested_unit": "patients", "frequency": 13.24, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["stad_tcga_pan_can_atlas_2018"], "source_ids": ["stad_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "KMT2C", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "KMT2C amplification", "genomic_coordinate": null, "observed": 14, "observed_status": "observed", "observed_unit": "patients", "tested": 108, "tested_status": "observed", "tested_unit": "patients", "frequency": 12.96, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["stad_oncosg_2018"], "source_ids": ["stad_oncosg_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "KRAS", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "KRAS amplification", "genomic_coordinate": null, "observed": 11, "observed_status": "observed", "observed_unit": "patients", "tested": 108, "tested_status": "observed", "tested_unit": "patients", "frequency": 10.19, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["stad_oncosg_2018"], "source_ids": ["stad_oncosg_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "SDK1", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "SDK1 amplification", "genomic_coordinate": null, "observed": 11, "observed_status": "observed", "observed_unit": "patients", "tested": 108, "tested_status": "observed", "tested_unit": "patients", "frequency": 10.19, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["stad_oncosg_2018"], "source_ids": ["stad_oncosg_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "GLI3", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "GLI3 amplification", "genomic_coordinate": null, "observed": 11, "observed_status": "observed", "observed_unit": "patients", "tested": 108, "tested_status": "observed", "tested_unit": "patients", "frequency": 10.19, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["stad_oncosg_2018"], "source_ids": ["stad_oncosg_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "HERC2", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "HERC2 amplification", "genomic_coordinate": null, "observed": 10, "observed_status": "observed", "observed_unit": "patients", "tested": 108, "tested_status": "observed", "tested_unit": "patients", "frequency": 9.26, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["stad_oncosg_2018"], "source_ids": ["stad_oncosg_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "RELN", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "RELN amplification", "genomic_coordinate": null, "observed": 9, "observed_status": "observed", "observed_unit": "patients", "tested": 108, "tested_status": "observed", "tested_unit": "patients", "frequency": 8.33, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["stad_oncosg_2018"], "source_ids": ["stad_oncosg_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "KRAS", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "KRAS amplification", "genomic_coordinate": null, "observed": 73, "observed_status": "observed", "observed_unit": "patients", "tested": 902, "tested_status": "observed", "tested_unit": "patients", "frequency": 8.09, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["egc_msk_2023"], "source_ids": ["egc_msk_2023_cna"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "KRAS", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "KRAS amplification", "genomic_coordinate": null, "observed": 35, "observed_status": "observed", "observed_unit": "patients", "tested": 438, "tested_status": "observed", "tested_unit": "patients", "frequency": 7.99, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["stad_tcga_pan_can_atlas_2018"], "source_ids": ["stad_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "TRRAP", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "TRRAP amplification", "genomic_coordinate": null, "observed": 29, "observed_status": "observed", "observed_unit": "patients", "tested": 438, "tested_status": "observed", "tested_unit": "patients", "frequency": 6.62, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["stad_tcga_pan_can_atlas_2018"], "source_ids": ["stad_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "MET", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "MET amplification", "genomic_coordinate": null, "observed": 7, "observed_status": "observed", "observed_unit": "patients", "tested": 108, "tested_status": "observed", "tested_unit": "patients", "frequency": 6.48, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["stad_oncosg_2018"], "source_ids": ["stad_oncosg_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "LAMA1", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "LAMA1 amplification", "genomic_coordinate": null, "observed": 7, "observed_status": "observed", "observed_unit": "patients", "tested": 108, "tested_status": "observed", "tested_unit": "patients", "frequency": 6.48, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["stad_oncosg_2018"], "source_ids": ["stad_oncosg_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "PLXNA4", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "PLXNA4 amplification", "genomic_coordinate": null, "observed": 7, "observed_status": "observed", "observed_unit": "patients", "tested": 108, "tested_status": "observed", "tested_unit": "patients", "frequency": 6.48, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["stad_oncosg_2018"], "source_ids": ["stad_oncosg_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "VPS13B", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "VPS13B amplification", "genomic_coordinate": null, "observed": 27, "observed_status": "observed", "observed_unit": "patients", "tested": 438, "tested_status": "observed", "tested_unit": "patients", "frequency": 6.16, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["stad_tcga_pan_can_atlas_2018"], "source_ids": ["stad_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "PIK3CA", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "PIK3CA amplification", "genomic_coordinate": null, "observed": 24, "observed_status": "observed", "observed_unit": "patients", "tested": 438, "tested_status": "observed", "tested_unit": "patients", "frequency": 5.48, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["stad_tcga_pan_can_atlas_2018"], "source_ids": ["stad_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "RIMS2", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "RIMS2 amplification", "genomic_coordinate": null, "observed": 23, "observed_status": "observed", "observed_unit": "patients", "tested": 438, "tested_status": "observed", "tested_unit": "patients", "frequency": 5.25, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["stad_tcga_pan_can_atlas_2018"], "source_ids": ["stad_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "TG", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "TG amplification", "genomic_coordinate": null, "observed": 22, "observed_status": "observed", "observed_unit": "patients", "tested": 438, "tested_status": "observed", "tested_unit": "patients", "frequency": 5.02, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["stad_tcga_pan_can_atlas_2018"], "source_ids": ["stad_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "COL12A1", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "COL12A1 amplification", "genomic_coordinate": null, "observed": 5, "observed_status": "observed", "observed_unit": "patients", "tested": 108, "tested_status": "observed", "tested_unit": "patients", "frequency": 4.63, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["stad_oncosg_2018"], "source_ids": ["stad_oncosg_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "NAV3", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "NAV3 amplification", "genomic_coordinate": null, "observed": 5, "observed_status": "observed", "observed_unit": "patients", "tested": 108, "tested_status": "observed", "tested_unit": "patients", "frequency": 4.63, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["stad_oncosg_2018"], "source_ids": ["stad_oncosg_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "PTPRT", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "PTPRT amplification", "genomic_coordinate": null, "observed": 20, "observed_status": "observed", "observed_unit": "patients", "tested": 438, "tested_status": "observed", "tested_unit": "patients", "frequency": 4.57, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["stad_tcga_pan_can_atlas_2018"], "source_ids": ["stad_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "FGFR2", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "FGFR2 amplification", "genomic_coordinate": null, "observed": 19, "observed_status": "observed", "observed_unit": "patients", "tested": 438, "tested_status": "observed", "tested_unit": "patients", "frequency": 4.34, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["stad_tcga_pan_can_atlas_2018"], "source_ids": ["stad_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "UBR5", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "UBR5 amplification", "genomic_coordinate": null, "observed": 18, "observed_status": "observed", "observed_unit": "patients", "tested": 438, "tested_status": "observed", "tested_unit": "patients", "frequency": 4.11, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["stad_tcga_pan_can_atlas_2018"], "source_ids": ["stad_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "FGFR2", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "FGFR2 amplification", "genomic_coordinate": null, "observed": 37, "observed_status": "observed", "observed_unit": "patients", "tested": 902, "tested_status": "observed", "tested_unit": "patients", "frequency": 4.1, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["egc_msk_2023"], "source_ids": ["egc_msk_2023_cna"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "RELN", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "RELN amplification", "genomic_coordinate": null, "observed": 17, "observed_status": "observed", "observed_unit": "patients", "tested": 438, "tested_status": "observed", "tested_unit": "patients", "frequency": 3.88, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["stad_tcga_pan_can_atlas_2018"], "source_ids": ["stad_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "PIK3CA", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "PIK3CA amplification", "genomic_coordinate": null, "observed": 4, "observed_status": "observed", "observed_unit": "patients", "tested": 108, "tested_status": "observed", "tested_unit": "patients", "frequency": 3.7, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["stad_oncosg_2018"], "source_ids": ["stad_oncosg_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "CD274", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "CD274 amplification", "genomic_coordinate": null, "observed": 4, "observed_status": "observed", "observed_unit": "patients", "tested": 108, "tested_status": "observed", "tested_unit": "patients", "frequency": 3.7, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["stad_oncosg_2018"], "source_ids": ["stad_oncosg_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "CD274", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "deep deletion", "event_label": "CD274 deep deletion", "genomic_coordinate": null, "observed": 4, "observed_status": "observed", "observed_unit": "patients", "tested": 108, "tested_status": "observed", "tested_unit": "patients", "frequency": 3.7, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["stad_oncosg_2018"], "source_ids": ["stad_oncosg_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "CDH23", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "CDH23 amplification", "genomic_coordinate": null, "observed": 4, "observed_status": "observed", "observed_unit": "patients", "tested": 108, "tested_status": "observed", "tested_unit": "patients", "frequency": 3.7, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["stad_oncosg_2018"], "source_ids": ["stad_oncosg_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "ADGRB3", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "ADGRB3 amplification", "genomic_coordinate": null, "observed": 4, "observed_status": "observed", "observed_unit": "patients", "tested": 108, "tested_status": "observed", "tested_unit": "patients", "frequency": 3.7, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["stad_oncosg_2018"], "source_ids": ["stad_oncosg_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "MET", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "MET amplification", "genomic_coordinate": null, "observed": 32, "observed_status": "observed", "observed_unit": "patients", "tested": 902, "tested_status": "observed", "tested_unit": "patients", "frequency": 3.55, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["egc_msk_2023"], "source_ids": ["egc_msk_2023_cna"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "SDK1", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "SDK1 amplification", "genomic_coordinate": null, "observed": 14, "observed_status": "observed", "observed_unit": "patients", "tested": 438, "tested_status": "observed", "tested_unit": "patients", "frequency": 3.2, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["stad_tcga_pan_can_atlas_2018"], "source_ids": ["stad_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "TCHH", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "TCHH amplification", "genomic_coordinate": null, "observed": 13, "observed_status": "observed", "observed_unit": "patients", "tested": 438, "tested_status": "observed", "tested_unit": "patients", "frequency": 2.97, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["stad_tcga_pan_can_atlas_2018"], "source_ids": ["stad_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "FGFR2", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "FGFR2 amplification", "genomic_coordinate": null, "observed": 3, "observed_status": "observed", "observed_unit": "patients", "tested": 108, "tested_status": "observed", "tested_unit": "patients", "frequency": 2.78, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["stad_oncosg_2018"], "source_ids": ["stad_oncosg_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "TP53", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "deep deletion", "event_label": "TP53 deep deletion", "genomic_coordinate": null, "observed": 3, "observed_status": "observed", "observed_unit": "patients", "tested": 108, "tested_status": "observed", "tested_unit": "patients", "frequency": 2.78, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["stad_oncosg_2018"], "source_ids": ["stad_oncosg_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "PCDH15", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "PCDH15 amplification", "genomic_coordinate": null, "observed": 3, "observed_status": "observed", "observed_unit": "patients", "tested": 108, "tested_status": "observed", "tested_unit": "patients", "frequency": 2.78, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["stad_oncosg_2018"], "source_ids": ["stad_oncosg_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "ERBB4", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "ERBB4 amplification", "genomic_coordinate": null, "observed": 3, "observed_status": "observed", "observed_unit": "patients", "tested": 108, "tested_status": "observed", "tested_unit": "patients", "frequency": 2.78, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["stad_oncosg_2018"], "source_ids": ["stad_oncosg_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "MET", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "MET amplification", "genomic_coordinate": null, "observed": 12, "observed_status": "observed", "observed_unit": "patients", "tested": 438, "tested_status": "observed", "tested_unit": "patients", "frequency": 2.74, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["stad_tcga_pan_can_atlas_2018"], "source_ids": ["stad_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "KMT2C", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "deep deletion", "event_label": "KMT2C deep deletion", "genomic_coordinate": null, "observed": 12, "observed_status": "observed", "observed_unit": "patients", "tested": 438, "tested_status": "observed", "tested_unit": "patients", "frequency": 2.74, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["stad_tcga_pan_can_atlas_2018"], "source_ids": ["stad_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "CDH23", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "CDH23 amplification", "genomic_coordinate": null, "observed": 12, "observed_status": "observed", "observed_unit": "patients", "tested": 438, "tested_status": "observed", "tested_unit": "patients", "frequency": 2.74, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["stad_tcga_pan_can_atlas_2018"], "source_ids": ["stad_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "ARID1A", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "deep deletion", "event_label": "ARID1A deep deletion", "genomic_coordinate": null, "observed": 11, "observed_status": "observed", "observed_unit": "patients", "tested": 438, "tested_status": "observed", "tested_unit": "patients", "frequency": 2.51, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["stad_tcga_pan_can_atlas_2018"], "source_ids": ["stad_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "CD274", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "deep deletion", "event_label": "CD274 deep deletion", "genomic_coordinate": null, "observed": 11, "observed_status": "observed", "observed_unit": "patients", "tested": 438, "tested_status": "observed", "tested_unit": "patients", "frequency": 2.51, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["stad_tcga_pan_can_atlas_2018"], "source_ids": ["stad_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "CD274", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "CD274 amplification", "genomic_coordinate": null, "observed": 10, "observed_status": "observed", "observed_unit": "patients", "tested": 438, "tested_status": "observed", "tested_unit": "patients", "frequency": 2.28, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["stad_tcga_pan_can_atlas_2018"], "source_ids": ["stad_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "PREX2", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "PREX2 amplification", "genomic_coordinate": null, "observed": 10, "observed_status": "observed", "observed_unit": "patients", "tested": 438, "tested_status": "observed", "tested_unit": "patients", "frequency": 2.28, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["stad_tcga_pan_can_atlas_2018"], "source_ids": ["stad_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "APC", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "deep deletion", "event_label": "APC deep deletion", "genomic_coordinate": null, "observed": 9, "observed_status": "observed", "observed_unit": "patients", "tested": 438, "tested_status": "observed", "tested_unit": "patients", "frequency": 2.05, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["stad_tcga_pan_can_atlas_2018"], "source_ids": ["stad_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}], "modality_summary": [{"modality": "SNV / small indel", "available_cohorts": 3, "total_cohorts": 3}, {"modality": "Copy number (discrete)", "available_cohorts": 3, "total_cohorts": 3}, {"modality": "Structural variant (present, not read)", "available_cohorts": 2, "total_cohorts": 3}], "chromosome_summary": [], "cohorts": [{"name": "Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "source": "cBioPortal", "accession": "stad_tcga_pan_can_atlas_2018", "patients": {"value": 436, "status": "observed", "unit": "patients"}, "samples": {"value": 436, "status": "observed", "unit": "samples"}, "disease_subtype": "Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "assay_type": "exome or genome", "sequencing_method": "WES (436)", "genome_build": "hg19", "alteration_types_available": ["SNV", "small indel", "amplification", "deep deletion", "structural variant (profile present, not read)"], "genes_assayed": "all coding genes", "primary_or_metastatic": null, "age_group": null, "retrieved_at": "2026-09-18", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "source_record_id": "stad_tcga_pan_can_atlas_2018", "is_demo": false, "assay_coverage": {"patients_with_calls": 436, "patients_in_roster": 436, "frequencies_computed": true, "samples_sequenced": 436, "samples_in_study": 440, "hypermutated_patients": 41, "median_mutations_per_sample": 111.5, "reason": null}}, {"name": "Gastric Cancer (OncoSG, 2018)", "source": "cBioPortal", "accession": "stad_oncosg_2018", "patients": {"value": 147, "status": "observed", "unit": "patients"}, "samples": {"value": 147, "status": "observed", "unit": "samples"}, "disease_subtype": "Gastric Cancer (OncoSG, 2018)", "assay_type": "exome or genome", "sequencing_method": "WES (147)", "genome_build": "hg19", "alteration_types_available": ["SNV", "small indel", "amplification", "deep deletion"], "genes_assayed": "all coding genes", "primary_or_metastatic": null, "age_group": null, "retrieved_at": "2026-09-18", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "source_record_id": "stad_oncosg_2018", "is_demo": false, "assay_coverage": {"patients_with_calls": 147, "patients_in_roster": 147, "frequencies_computed": true, "samples_sequenced": 147, "samples_in_study": 147, "hypermutated_patients": 7, "median_mutations_per_sample": 82, "reason": null}}, {"name": "Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "source": "cBioPortal", "accession": "egc_msk_2023", "patients": {"value": 902, "status": "observed", "unit": "patients"}, "samples": {"value": 902, "status": "observed", "unit": "samples"}, "disease_subtype": "Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "assay_type": "targeted panel", "sequencing_method": "IMPACT468 (616), IMPACT410 (179), IMPACT341 (92), IMPACT505 (15)", "genome_build": "hg19", "alteration_types_available": ["SNV", "small indel", "amplification", "deep deletion", "structural variant (profile present, not read)"], "genes_assayed": "panel genes only; per-gene denominators", "primary_or_metastatic": null, "age_group": null, "retrieved_at": "2026-09-18", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "source_record_id": "egc_msk_2023", "is_demo": false, "assay_coverage": {"patients_with_calls": 902, "patients_in_roster": 902, "frequencies_computed": true, "samples_sequenced": 902, "samples_in_study": 902, "hypermutated_patients": 4, "median_mutations_per_sample": 5.0, "reason": null}}], "sources": [{"source_name": "cBioPortal · Stomach Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_tcga_pan_can_atlas_2018", "source_record_id": "stad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Gastric Cancer (OncoSG, 2018)", "source_url": "https://www.cbioportal.org/study/summary?id=stad_oncosg_2018", "source_record_id": "stad_oncosg_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=egc_msk_2023", "source_record_id": "egc_msk_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "limitations": ["A cBioPortal public-API snapshot retrieved 2026-09-18; the page does not refresh source data at request time.", "Counts are patients with at least one non-silent call in the study's sequenced sample list; silent, intronic and UTR calls are excluded.", "For targeted-panel cohorts each gene divides by the patients whose panel carried it; a gene absent from the panel is shown as not assayed, not as zero.", "Copy-number rows use discrete calls (2 = high-level amplification, −2 = deep deletion) against the cohort's copy-number sample list, which is a different roster from the sequenced one.", "Cohorts are not pooled. Cross-study patient overlap has not been checked and no disease-wide frequency is reported.", "Structural variants and fusions are not read in this snapshot even where the study carries a profile; germline variants, mutational signatures, TMB and MSI are not reported.", "The gene set is the briefing's curated targets plus the reference cohort's most frequently mutated genes; it is not genome-wide."], "answer_block": ["In Stomach Adenocarcinoma (TCGA, PanCancer Atlas) (436 sequenced patients, exome or genome), the most frequently altered of the 49 genes shown are TP53 48.62%, ARID1A 25.23%, KMT2D 16.74%, PIK3CA 16.28%, PCDH15 16.28%. Each figure divides by the patients on whom that gene could be called.", "41 of 436 patients are hypermutated (more than 1115 non-silent mutations, ten times the cohort median of 112); every gene's frequency without them is beside the headline.", "Of the briefing's 12 curated targets, 1 are altered in under 2% of this cohort (CLDN18): targets by expression, dependency or drug label, not by mutation. Frequency is not targetability, in either direction.", "3 cohorts are shown and none are pooled; overlap between them has not been checked and there is no disease-wide percentage."], "key_findings": [{"finding": "TP53 is mutated in 212 of 436 patients in Stomach Adenocarcinoma (TCGA, PanCancer Atlas).", "numerator": 212, "denominator": 436, "frequency": 48.62, "cohorts": 3, "evidence_confidence": "moderate", "source": "stad_tcga_pan_can_atlas_2018", "retrieved_at": "2026-09-18"}, {"finding": "ARID1A is mutated in 110 of 436 patients in Stomach Adenocarcinoma (TCGA, PanCancer Atlas).", "numerator": 110, "denominator": 436, "frequency": 25.23, "cohorts": 3, "evidence_confidence": "moderate", "source": "stad_tcga_pan_can_atlas_2018", "retrieved_at": "2026-09-18"}, {"finding": "KMT2D is mutated in 73 of 436 patients in Stomach Adenocarcinoma (TCGA, PanCancer Atlas).", "numerator": 73, "denominator": 436, "frequency": 16.74, "cohorts": 3, "evidence_confidence": "moderate", "source": "stad_tcga_pan_can_atlas_2018", "retrieved_at": "2026-09-18"}], "research_gaps": [{"kind": "Structural variants", "text": "Read the structural-variant profiles the studies carry; fusions are the defining event in several of these diseases."}, {"kind": "Context", "text": "Stage, subtype, age and treatment line are not attached to any count; the cohorts differ on all four."}, {"kind": "Interpretation", "text": "Activating versus inactivating, actionable versus not, and evidence level are not inferred here; the briefing's target table carries the drug and trial facts."}], "observations": [], "data_status": "PUBLIC SOURCE SNAPSHOT", "is_demo": false, "reference_cohort": "stad_tcga_pan_can_atlas_2018", "region_events": [], "matrix": [{"label": "ERBB2", "kind": "SNV / small indel", "gene": "ERBB2", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 5.28, "altered": 23, "tested": 436, "note": null}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 8.84, "altered": 13, "tested": 147, "note": null}, {"cohort": "egc_msk_2023", "status": "observed", "frequency": 4.32, "altered": 39, "tested": 902, "note": null}]}, {"label": "ERBB2", "kind": "amplification", "gene": "ERBB2", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 13.24, "altered": 58, "tested": 438, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 15.74, "altered": 17, "tested": 108, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "egc_msk_2023", "status": "observed", "frequency": 14.97, "altered": 135, "tested": 902, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "CLDN18", "kind": "SNV / small indel", "gene": "CLDN18", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 0.69, "altered": 3, "tested": 436, "note": null}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 0.68, "altered": 1, "tested": 147, "note": null}, {"cohort": "egc_msk_2023", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "FGFR2", "kind": "SNV / small indel", "gene": "FGFR2", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.67, "altered": 16, "tested": 436, "note": null}, {"cohort": "stad_oncosg_2018", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 147, "note": null}, {"cohort": "egc_msk_2023", "status": "observed", "frequency": 1.55, "altered": 14, "tested": 902, "note": null}]}, {"label": "FGFR2", "kind": "amplification", "gene": "FGFR2", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 4.34, "altered": 19, "tested": 438, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 2.78, "altered": 3, "tested": 108, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "egc_msk_2023", "status": "observed", "frequency": 4.1, "altered": 37, "tested": 902, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "MET", "kind": "SNV / small indel", "gene": "MET", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 1.61, "altered": 7, "tested": 436, "note": null}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 0.68, "altered": 1, "tested": 147, "note": null}, {"cohort": "egc_msk_2023", "status": "observed", "frequency": 1.55, "altered": 14, "tested": 902, "note": null}]}, {"label": "MET", "kind": "amplification", "gene": "MET", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 2.74, "altered": 12, "tested": 438, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 6.48, "altered": 7, "tested": 108, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "egc_msk_2023", "status": "observed", "frequency": 3.55, "altered": 32, "tested": 902, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "TP53", "kind": "SNV / small indel", "gene": "TP53", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 48.62, "altered": 212, "tested": 436, "note": null}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 45.58, "altered": 67, "tested": 147, "note": null}, {"cohort": "egc_msk_2023", "status": "observed", "frequency": 67.74, "altered": 611, "tested": 902, "note": null}]}, {"label": "TP53", "kind": "deep deletion", "gene": "TP53", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 1.14, "altered": 5, "tested": 438, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 2.78, "altered": 3, "tested": 108, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "egc_msk_2023", "status": "observed", "frequency": 0.33, "altered": 3, "tested": 902, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "CDH1", "kind": "SNV / small indel", "gene": "CDH1", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 9.4, "altered": 41, "tested": 436, "note": null}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 6.12, "altered": 9, "tested": 147, "note": null}, {"cohort": "egc_msk_2023", "status": "observed", "frequency": 10.31, "altered": 93, "tested": 902, "note": null}]}, {"label": "PIK3CA", "kind": "SNV / small indel", "gene": "PIK3CA", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 16.28, "altered": 71, "tested": 436, "note": null}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 4.76, "altered": 7, "tested": 147, "note": null}, {"cohort": "egc_msk_2023", "status": "observed", "frequency": 8.76, "altered": 79, "tested": 902, "note": null}]}, {"label": "PIK3CA", "kind": "amplification", "gene": "PIK3CA", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 5.48, "altered": 24, "tested": 438, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 3.7, "altered": 4, "tested": 108, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "egc_msk_2023", "status": "observed", "frequency": 1.22, "altered": 11, "tested": 902, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "KRAS", "kind": "SNV / small indel", "gene": "KRAS", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 9.17, "altered": 40, "tested": 436, "note": null}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 6.12, "altered": 9, "tested": 147, "note": null}, {"cohort": "egc_msk_2023", "status": "observed", "frequency": 6.87, "altered": 62, "tested": 902, "note": null}]}, {"label": "KRAS", "kind": "amplification", "gene": "KRAS", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 7.99, "altered": 35, "tested": 438, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 10.19, "altered": 11, "tested": 108, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "egc_msk_2023", "status": "observed", "frequency": 8.09, "altered": 73, "tested": 902, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "ARID1A", "kind": "SNV / small indel", "gene": "ARID1A", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 25.23, "altered": 110, "tested": 436, "note": null}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 11.56, "altered": 17, "tested": 147, "note": null}, {"cohort": "egc_msk_2023", "status": "observed", "frequency": 14.97, "altered": 135, "tested": 902, "note": null}]}, {"label": "ARID1A", "kind": "deep deletion", "gene": "ARID1A", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 2.51, "altered": 11, "tested": 438, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 0.93, "altered": 1, "tested": 108, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "egc_msk_2023", "status": "observed", "frequency": 0.55, "altered": 5, "tested": 902, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "RHOA", "kind": "SNV / small indel", "gene": "RHOA", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 5.05, "altered": 22, "tested": 436, "note": null}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 2.72, "altered": 4, "tested": 147, "note": null}, {"cohort": "egc_msk_2023", "status": "observed", "frequency": 5.21, "altered": 47, "tested": 902, "note": null}]}, {"label": "CD274", "kind": "SNV / small indel", "gene": "CD274", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 0.92, "altered": 4, "tested": 436, "note": null}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 0.68, "altered": 1, "tested": 147, "note": null}, {"cohort": "egc_msk_2023", "status": "observed", "frequency": 0.11, "altered": 1, "tested": 902, "note": null}]}, {"label": "CD274", "kind": "amplification", "gene": "CD274", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 2.28, "altered": 10, "tested": 438, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 3.7, "altered": 4, "tested": 108, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "egc_msk_2023", "status": "observed", "frequency": 0.22, "altered": 2, "tested": 902, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "CD274", "kind": "deep deletion", "gene": "CD274", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 2.51, "altered": 11, "tested": 438, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 3.7, "altered": 4, "tested": 108, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "egc_msk_2023", "status": "observed", "frequency": 0.55, "altered": 5, "tested": 902, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "KDR", "kind": "SNV / small indel", "gene": "KDR", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.21, "altered": 14, "tested": 436, "note": null}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 3.4, "altered": 5, "tested": 147, "note": null}, {"cohort": "egc_msk_2023", "status": "observed", "frequency": 1.44, "altered": 13, "tested": 902, "note": null}]}, {"label": "KMT2D", "kind": "SNV / small indel", "gene": "KMT2D", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 16.74, "altered": 73, "tested": 436, "note": null}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 4.08, "altered": 6, "tested": 147, "note": null}, {"cohort": "egc_msk_2023", "status": "observed", "frequency": 10.75, "altered": 97, "tested": 902, "note": null}]}, {"label": "PCDH15", "kind": "SNV / small indel", "gene": "PCDH15", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 16.28, "altered": 71, "tested": 436, "note": null}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 8.16, "altered": 12, "tested": 147, "note": null}, {"cohort": "egc_msk_2023", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "PCDH15", "kind": "amplification", "gene": "PCDH15", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 0.46, "altered": 2, "tested": 438, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 2.78, "altered": 3, "tested": 108, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "egc_msk_2023", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 902, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "COL12A1", "kind": "SNV / small indel", "gene": "COL12A1", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 14.22, "altered": 62, "tested": 436, "note": null}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 7.48, "altered": 11, "tested": 147, "note": null}, {"cohort": "egc_msk_2023", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "COL12A1", "kind": "amplification", "gene": "COL12A1", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 1.14, "altered": 5, "tested": 438, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 4.63, "altered": 5, "tested": 108, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "egc_msk_2023", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 902, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "LRRK2", "kind": "SNV / small indel", "gene": "LRRK2", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 13.99, "altered": 61, "tested": 436, "note": null}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 4.08, "altered": 6, "tested": 147, "note": null}, {"cohort": "egc_msk_2023", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "LAMA1", "kind": "SNV / small indel", "gene": "LAMA1", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 13.99, "altered": 61, "tested": 436, "note": null}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 7.48, "altered": 11, "tested": 147, "note": null}, {"cohort": "egc_msk_2023", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "LAMA1", "kind": "amplification", "gene": "LAMA1", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 0.68, "altered": 3, "tested": 438, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 6.48, "altered": 7, "tested": 108, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "egc_msk_2023", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 902, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "KMT2C", "kind": "SNV / small indel", "gene": "KMT2C", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 13.76, "altered": 60, "tested": 436, "note": null}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 10.2, "altered": 15, "tested": 147, "note": null}, {"cohort": "egc_msk_2023", "status": "observed", "frequency": 5.32, "altered": 48, "tested": 902, "note": null}]}, {"label": "KMT2C", "kind": "amplification", "gene": "KMT2C", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 0.68, "altered": 3, "tested": 438, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 12.96, "altered": 14, "tested": 108, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "egc_msk_2023", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 902, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "KMT2C", "kind": "deep deletion", "gene": "KMT2C", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 2.74, "altered": 12, "tested": 438, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "stad_oncosg_2018", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 108, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "egc_msk_2023", "status": "observed", "frequency": 0.33, "altered": 3, "tested": 902, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "FAT2", "kind": "SNV / small indel", "gene": "FAT2", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 13.3, "altered": 58, "tested": 436, "note": null}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 4.08, "altered": 6, "tested": 147, "note": null}, {"cohort": "egc_msk_2023", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "NBEA", "kind": "SNV / small indel", "gene": "NBEA", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 12.84, "altered": 56, "tested": 436, "note": null}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 10.88, "altered": 16, "tested": 147, "note": null}, {"cohort": "egc_msk_2023", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "NBEA", "kind": "amplification", "gene": "NBEA", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 1.83, "altered": 8, "tested": 438, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 14.81, "altered": 16, "tested": 108, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "egc_msk_2023", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 902, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "TG", "kind": "SNV / small indel", "gene": "TG", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 12.61, "altered": 55, "tested": 436, "note": null}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 6.12, "altered": 9, "tested": 147, "note": null}, {"cohort": "egc_msk_2023", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "TG", "kind": "amplification", "gene": "TG", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 5.02, "altered": 22, "tested": 438, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 26.85, "altered": 29, "tested": 108, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "egc_msk_2023", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 902, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "SDK1", "kind": "SNV / small indel", "gene": "SDK1", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 12.39, "altered": 54, "tested": 436, "note": null}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 8.84, "altered": 13, "tested": 147, "note": null}, {"cohort": "egc_msk_2023", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "SDK1", "kind": "amplification", "gene": "SDK1", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.2, "altered": 14, "tested": 438, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 10.19, "altered": 11, "tested": 108, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "egc_msk_2023", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 902, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "RNF213", "kind": "SNV / small indel", "gene": "RNF213", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 12.39, "altered": 54, "tested": 436, "note": null}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 6.12, "altered": 9, "tested": 147, "note": null}, {"cohort": "egc_msk_2023", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "PCDH10", "kind": "SNV / small indel", "gene": "PCDH10", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 12.39, "altered": 54, "tested": 436, "note": null}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 7.48, "altered": 11, "tested": 147, "note": null}, {"cohort": "egc_msk_2023", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "MDN1", "kind": "SNV / small indel", "gene": "MDN1", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 12.39, "altered": 54, "tested": 436, "note": null}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 9.52, "altered": 14, "tested": 147, "note": null}, {"cohort": "egc_msk_2023", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "GLI3", "kind": "SNV / small indel", "gene": "GLI3", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 12.39, "altered": 54, "tested": 436, "note": null}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 8.16, "altered": 12, "tested": 147, "note": null}, {"cohort": "egc_msk_2023", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "GLI3", "kind": "amplification", "gene": "GLI3", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 0.91, "altered": 4, "tested": 438, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 10.19, "altered": 11, "tested": 108, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "egc_msk_2023", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 902, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "PREX2", "kind": "SNV / small indel", "gene": "PREX2", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 12.16, "altered": 53, "tested": 436, "note": null}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 7.48, "altered": 11, "tested": 147, "note": null}, {"cohort": "egc_msk_2023", "status": "observed", "frequency": 9.35, "altered": 59, "tested": 631, "note": null}]}, {"label": "PREX2", "kind": "amplification", "gene": "PREX2", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 2.28, "altered": 10, "tested": 438, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 14.81, "altered": 16, "tested": 108, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "egc_msk_2023", "status": "observed", "frequency": 0.11, "altered": 1, "tested": 902, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "PXDN", "kind": "SNV / small indel", "gene": "PXDN", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 11.93, "altered": 52, "tested": 436, "note": null}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 5.44, "altered": 8, "tested": 147, "note": null}, {"cohort": "egc_msk_2023", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "PTPRT", "kind": "SNV / small indel", "gene": "PTPRT", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 11.93, "altered": 52, "tested": 436, "note": null}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 5.44, "altered": 8, "tested": 147, "note": null}, {"cohort": "egc_msk_2023", "status": "observed", "frequency": 6.76, "altered": 61, "tested": 902, "note": null}]}, {"label": "PTPRT", "kind": "amplification", "gene": "PTPRT", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 4.57, "altered": 20, "tested": 438, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 31.48, "altered": 34, "tested": 108, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "egc_msk_2023", "status": "observed", "frequency": 0.55, "altered": 5, "tested": 902, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "ERBB4", "kind": "SNV / small indel", "gene": "ERBB4", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 11.93, "altered": 52, "tested": 436, "note": null}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 4.08, "altered": 6, "tested": 147, "note": null}, {"cohort": "egc_msk_2023", "status": "observed", "frequency": 5.88, "altered": 53, "tested": 902, "note": null}]}, {"label": "ERBB4", "kind": "amplification", "gene": "ERBB4", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 0.23, "altered": 1, "tested": 438, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 2.78, "altered": 3, "tested": 108, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "egc_msk_2023", "status": "observed", "frequency": 0.11, "altered": 1, "tested": 902, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "CMYA5", "kind": "SNV / small indel", "gene": "CMYA5", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 11.93, "altered": 52, "tested": 436, "note": null}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 2.72, "altered": 4, "tested": 147, "note": null}, {"cohort": "egc_msk_2023", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "CDH23", "kind": "SNV / small indel", "gene": "CDH23", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 11.93, "altered": 52, "tested": 436, "note": null}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 4.08, "altered": 6, "tested": 147, "note": null}, {"cohort": "egc_msk_2023", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "CDH23", "kind": "amplification", "gene": "CDH23", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 2.74, "altered": 12, "tested": 438, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 3.7, "altered": 4, "tested": 108, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "egc_msk_2023", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 902, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "VPS13B", "kind": "SNV / small indel", "gene": "VPS13B", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 11.7, "altered": 51, "tested": 436, "note": null}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 3.4, "altered": 5, "tested": 147, "note": null}, {"cohort": "egc_msk_2023", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "VPS13B", "kind": "amplification", "gene": "VPS13B", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 6.16, "altered": 27, "tested": 438, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 26.85, "altered": 29, "tested": 108, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "egc_msk_2023", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 902, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "PLXNA4", "kind": "SNV / small indel", "gene": "PLXNA4", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 11.7, "altered": 51, "tested": 436, "note": null}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 4.76, "altered": 7, "tested": 147, "note": null}, {"cohort": "egc_msk_2023", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "PLXNA4", "kind": "amplification", "gene": "PLXNA4", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 0.68, "altered": 3, "tested": 438, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 6.48, "altered": 7, "tested": 108, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "egc_msk_2023", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 902, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "NAV3", "kind": "SNV / small indel", "gene": "NAV3", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 11.7, "altered": 51, "tested": 436, "note": null}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 8.16, "altered": 12, "tested": 147, "note": null}, {"cohort": "egc_msk_2023", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "NAV3", "kind": "amplification", "gene": "NAV3", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 0.91, "altered": 4, "tested": 438, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 4.63, "altered": 5, "tested": 108, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "egc_msk_2023", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 902, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "DOCK3", "kind": "SNV / small indel", "gene": "DOCK3", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 11.7, "altered": 51, "tested": 436, "note": null}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 4.76, "altered": 7, "tested": 147, "note": null}, {"cohort": "egc_msk_2023", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "APC", "kind": "SNV / small indel", "gene": "APC", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 11.7, "altered": 51, "tested": 436, "note": null}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 6.8, "altered": 10, "tested": 147, "note": null}, {"cohort": "egc_msk_2023", "status": "observed", "frequency": 6.87, "altered": 62, "tested": 902, "note": null}]}, {"label": "APC", "kind": "deep deletion", "gene": "APC", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 2.05, "altered": 9, "tested": 438, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 1.85, "altered": 2, "tested": 108, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "egc_msk_2023", "status": "observed", "frequency": 0.11, "altered": 1, "tested": 902, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "ACVR2A", "kind": "SNV / small indel", "gene": "ACVR2A", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 11.47, "altered": 50, "tested": 436, "note": null}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 7.48, "altered": 11, "tested": 147, "note": null}, {"cohort": "egc_msk_2023", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "TRRAP", "kind": "SNV / small indel", "gene": "TRRAP", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 11.24, "altered": 49, "tested": 436, "note": null}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 6.12, "altered": 9, "tested": 147, "note": null}, {"cohort": "egc_msk_2023", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "TRRAP", "kind": "amplification", "gene": "TRRAP", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 6.62, "altered": 29, "tested": 438, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 13.89, "altered": 15, "tested": 108, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "egc_msk_2023", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 902, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "ABCA12", "kind": "SNV / small indel", "gene": "ABCA12", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 11.24, "altered": 49, "tested": 436, "note": null}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 4.08, "altered": 6, "tested": 147, "note": null}, {"cohort": "egc_msk_2023", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "RIMS2", "kind": "SNV / small indel", "gene": "RIMS2", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 11.01, "altered": 48, "tested": 436, "note": null}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 10.2, "altered": 15, "tested": 147, "note": null}, {"cohort": "egc_msk_2023", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "RIMS2", "kind": "amplification", "gene": "RIMS2", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 5.25, "altered": 23, "tested": 438, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 25.93, "altered": 28, "tested": 108, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "egc_msk_2023", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 902, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "RELN", "kind": "SNV / small indel", "gene": "RELN", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 11.01, "altered": 48, "tested": 436, "note": null}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 6.12, "altered": 9, "tested": 147, "note": null}, {"cohort": "egc_msk_2023", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "RELN", "kind": "amplification", "gene": "RELN", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.88, "altered": 17, "tested": 438, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 8.33, "altered": 9, "tested": 108, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "egc_msk_2023", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 902, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "HERC2", "kind": "SNV / small indel", "gene": "HERC2", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 11.01, "altered": 48, "tested": 436, "note": null}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 4.76, "altered": 7, "tested": 147, "note": null}, {"cohort": "egc_msk_2023", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "HERC2", "kind": "amplification", "gene": "HERC2", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 0.23, "altered": 1, "tested": 438, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 9.26, "altered": 10, "tested": 108, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "egc_msk_2023", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 902, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "COL6A3", "kind": "SNV / small indel", "gene": "COL6A3", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 11.01, "altered": 48, "tested": 436, "note": null}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 2.72, "altered": 4, "tested": 147, "note": null}, {"cohort": "egc_msk_2023", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "ADGRB3", "kind": "SNV / small indel", "gene": "ADGRB3", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 11.01, "altered": 48, "tested": 436, "note": null}, {"cohort": "stad_oncosg_2018", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 147, "note": null}, {"cohort": "egc_msk_2023", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "ADGRB3", "kind": "amplification", "gene": "ADGRB3", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 0.23, "altered": 1, "tested": 438, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 3.7, "altered": 4, "tested": 108, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "egc_msk_2023", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 902, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "NALCN", "kind": "SNV / small indel", "gene": "NALCN", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 10.78, "altered": 47, "tested": 436, "note": null}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 3.4, "altered": 5, "tested": 147, "note": null}, {"cohort": "egc_msk_2023", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "NALCN", "kind": "amplification", "gene": "NALCN", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 1.6, "altered": 7, "tested": 438, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 14.81, "altered": 16, "tested": 108, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "egc_msk_2023", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 902, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "CACNA1E", "kind": "SNV / small indel", "gene": "CACNA1E", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 10.78, "altered": 47, "tested": 436, "note": null}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 6.12, "altered": 9, "tested": 147, "note": null}, {"cohort": "egc_msk_2023", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "CACNA1E", "kind": "amplification", "gene": "CACNA1E", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 1.37, "altered": 6, "tested": 438, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 16.67, "altered": 18, "tested": 108, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "egc_msk_2023", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 902, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "UBR5", "kind": "SNV / small indel", "gene": "UBR5", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 10.55, "altered": 46, "tested": 436, "note": null}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 5.44, "altered": 8, "tested": 147, "note": null}, {"cohort": "egc_msk_2023", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "UBR5", "kind": "amplification", "gene": "UBR5", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 4.11, "altered": 18, "tested": 438, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 23.15, "altered": 25, "tested": 108, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "egc_msk_2023", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 902, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "TCHH", "kind": "SNV / small indel", "gene": "TCHH", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 10.55, "altered": 46, "tested": 436, "note": null}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 1.36, "altered": 2, "tested": 147, "note": null}, {"cohort": "egc_msk_2023", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "TCHH", "kind": "amplification", "gene": "TCHH", "cells": [{"cohort": "stad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 2.97, "altered": 13, "tested": 438, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "stad_oncosg_2018", "status": "observed", "frequency": 14.81, "altered": 16, "tested": 108, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "egc_msk_2023", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 902, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}]}