{
 "disease": "gastrointestinal-stromal-tumor",
 "label": "Gastrointestinal stromal tumour",
 "url": "https://usebiotransfer.org/disease/gastrointestinal-stromal-tumor/",
 "built": "2026-09-16",
 "facts_hash": {
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  "targets": "8b5351425307"
 },
 "sources": {
  "targets": "Open Targets Platform GraphQL API v4",
  "trials": "ClinicalTrials.gov API v2"
 },
 "retrieved": {
  "targets": "2026-09-16",
  "trials": "2026-09-16"
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 "query": {
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  "shape": "query.cond=<disease>&query.intr=<term>&pageSize=200",
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  "dedup": "by NCT id across synonyms",
  "study_types": "interventional counted in headline; observational reported separately",
  "known_floor": "trials naming an antigen only by product code are not retrieved by an intervention-name search"
 },
 "targets": [
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 "trials": {
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      "title": "A Study of HQP1351 in Patients With GIST or Other Solid Tumors",
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      "title": "A Prospective, Randomized, Multicenter, Comparative Study of the Efficacy of Imatinib Resumption Combined With Atezolizumab Versus Imatinib Resumption Alone in Patients With Unresectable Advanced Gastrointestinal Stromal Tumors (GIST) After Failure of Standard Treatments",
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     {
      "nct": "NCT05208047",
      "title": "(Peak) A Phase 3 Randomized Trial of CGT9486+Sunitinib vs. Sunitinib in Subjects With Gastrointestinal Stromal Tumors",
      "status": "RECRUITING",
      "last_update": "2026-06-16",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT05366816",
      "title": "ctDNA-Guided Sunitinib And Regorafenib Therapy for GIST",
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      "last_update": "2025-09-09",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05385549",
      "title": "5 Years of Adjuvant Imatinib in Patients With Gastrointestinal Stromal Tumor With a High Risk",
      "status": "RECRUITING",
      "last_update": "2025-08-08",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT05493215",
      "title": "Imatinib TDM in GIST",
      "status": "RECRUITING",
      "last_update": "2026-08-31",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05751733",
      "title": "Apatinib Mesylate Versus Standard Second-line TKI in the Treatment of Advanced GIST",
      "status": "RECRUITING",
      "last_update": "2023-03-02",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05905887",
      "title": "Rivoceranib Plus Paclitaxel in Patients With Gastrointestinal Stromal Tumor",
      "status": "RECRUITING",
      "last_update": "2026-04-07",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05957367",
      "title": "A Study of Inlexisertib (DCC-3116) in Combination With Anticancer Therapies in Participants With Advanced Malignancies",
      "status": "RECRUITING",
      "last_update": "2026-07-23",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06326346",
      "title": "GIST Oral Paclitaxel(Liporaxel)",
      "status": "RECRUITING",
      "last_update": "2026-04-07",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06507683",
      "title": "Evaluate the Efficacy and Safety of Radiotherapy Combined With Ripretinib in the Treatment of Unresectable Advanced GIST",
      "status": "RECRUITING",
      "last_update": "2024-07-18",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06630234",
      "title": "A Master Protocol to Evaluate DCC-3009 in Gastrointestinal Stromal Tumor (GIST)",
      "status": "RECRUITING",
      "last_update": "2026-02-05",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06640361",
      "title": "A Study of Olverembatinib in SDH-deficient GIST.",
      "status": "RECRUITING",
      "last_update": "2026-07-23",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06655246",
      "title": "A Study of Ziftomenib in Combination With Imatinib in Patients With Advanced Gastrointestinal Stromal Tumors (GIST)",
      "status": "RECRUITING",
      "last_update": "2026-02-05",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06805825",
      "title": "A Study of the c-Kit Specific Antibody-Drug Conjugate NN3201 for Advanced and/or Metastatic Solid Tumors Known to Express c-Kit",
      "status": "RECRUITING",
      "last_update": "2025-09-23",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07096609",
      "title": "Lenvatinib After Progression on Imatinib, Sunitinib, and Regorafenib for GIST Patients",
      "status": "RECRUITING",
      "last_update": "2026-04-03",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07171203",
      "title": "Preoperative Imatinib and Fampridine in KIT Mutant Gastrointestinal Stromal Tumor",
      "status": "RECRUITING",
      "last_update": "2026-05-27",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07218926",
      "title": "A Study of IDRX-42 (GSK6042981) Versus (vs) Sunitinib in Participants With Gastrointestinal Stromal Tumors After Imatinib Therapy",
      "status": "RECRUITING",
      "last_update": "2026-09-08",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07379047",
      "title": "Efficacy and Safety of NB003 in Patients With Advanced Gastrointestinal Stromal Tumors (GIST)",
      "status": "RECRUITING",
      "last_update": "2026-06-10",
      "phase": "PHASE2/PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07406633",
      "title": "KQB198 in Combination With Imatinib in Participants With Advanced/Metastatic GIST in 1st Line Setting (SynerGIST-1st Line)",
      "status": "RECRUITING",
      "last_update": "2026-08-10",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07559864",
      "title": "Comparing Regorafenib Combined With Envafolimab to Physician's Choice in Patients With Metastatic Gastrointestinal Stromal Tumors Harboring KIT Exon 17 Mutations Refractory to Standard Treatment",
      "status": "RECRUITING",
      "last_update": "2026-04-30",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07585266",
      "title": "A Study to Investigate Velzatinib Compared With Imatinib in Adult Participants With Previously Untreated Metastatic and/or Unresectable Gastrointestinal Stromal Tumors (StrateGIST Frontline)",
      "status": "RECRUITING",
      "last_update": "2026-08-19",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07689201",
      "title": "A Study of Velzatinib in Participants With Metastatic and/or Unresectable GIST After Imatinib, Sunitinib, Regorafenib, and Pimitespib",
      "status": "RECRUITING",
      "last_update": "2026-09-09",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00006357",
      "title": "STI571 in Treating Patients With Recurrent or Refractory Soft Tissue Sarcoma",
      "status": "COMPLETED",
      "last_update": "2012-09-24",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00009906",
      "title": "Comparison of Two Different Doses of STI571 in Treating Patients With Metastatic or Unresectable Gastrointestinal Stromal Tumor",
      "status": "TERMINATED",
      "last_update": "2014-12-23",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00025246",
      "title": "Imatinib Mesylate in Treating Patients With Gastrointestinal Stromal Tumor That Has Been Completely Removed During Surgery",
      "status": "COMPLETED",
      "last_update": "2013-02-20",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00025415",
      "title": "Imatinib Mesylate in Treating Patients With Advanced Cancer and Liver Dysfunction",
      "status": "COMPLETED",
      "last_update": "2013-02-07",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00028002",
      "title": "Neoadjuvant and Adjuvant Imatinib Mesylate in Treating Patients With Primary or Recurrent Malignant Gastrointestinal Stromal Tumor",
      "status": "COMPLETED",
      "last_update": "2020-10-26",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00030667",
      "title": "Imatinib Mesylate in Treating Patients With Relapsed or Refractory Solid Tumors of Childhood",
      "status": "COMPLETED",
      "last_update": "2015-04-15",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00041197",
      "title": "Imatinib Mesylate in Treating Patients With Primary Gastrointestinal Stromal Tumor That Has Been Completely Removed By Surgery",
      "status": "COMPLETED",
      "last_update": "2013-07-16",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00075218",
      "title": "A Study To Assess The Safety And Efficacy Of SU11248 In Patients With Gastrointestinal Stromal Tumor(GIST)",
      "status": "COMPLETED",
      "last_update": "2009-09-28",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00089960",
      "title": "Study of AMG 706 in Subjects With Advanced Gastrointestinal Stromal Tumors (GISTs)",
      "status": "COMPLETED",
      "last_update": "2013-04-29",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00091078",
      "title": "Oblimersen and Imatinib Mesylate in Treating Patients With Advanced Gastrointestinal Stromal Tumors That Cannot Be Removed By Surgery",
      "status": "TERMINATED",
      "last_update": "2013-06-05",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00103168",
      "title": "Imatinib Mesylate or Observation Only in Treating Patients Who Have Undergone Surgery for Localized Gastrointestinal Stromal Tumor",
      "status": "COMPLETED",
      "last_update": "2018-07-09",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00112632",
      "title": "Imatinib Mesylate in Treating Patients With Locally Advanced Gastrointestinal Stromal Tumor",
      "status": "COMPLETED",
      "last_update": "2012-03-08",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00116935",
      "title": "Study Comparing 12 Months Versus 36 Months of Imatinib in the Treatment of Gastrointestinal Stromal Tumor (GIST)",
      "status": "COMPLETED",
      "last_update": "2011-12-30",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00117299",
      "title": "PTK787/ZK222584 in the Treatment of Metastatic Gastrointestinal Stromal Tumors Resistant to Imatinib",
      "status": "COMPLETED",
      "last_update": "2010-05-27",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00135005",
      "title": "Study of AMN107 With Imatinib in Gastrointestinal Stromal Tumors (GIST)",
      "status": "COMPLETED",
      "last_update": "2020-12-08",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00137449",
      "title": "Study Of SU011248 Administered On A Continuous Daily Dosing Schedule In Patients With Gastrointestinal Stromal Tumor",
      "status": "COMPLETED",
      "last_update": "2009-09-15",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00171912",
      "title": "Imatinib Mesylate in Patients With Various Types of Malignancies Involving Activated Tyrosine Kinase Enzymes",
      "status": "COMPLETED",
      "last_update": "2017-02-23",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00171977",
      "title": "Post-Marketing Clinical Study of Postoperative Adjuvant Therapy With Imatinib Mesylate in Patients With Gastrointestinal Stromal Tumors (GIST)",
      "status": "COMPLETED",
      "last_update": "2012-08-07",
      "phase": "PHASE4",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00237172",
      "title": "Phase II Clinical Study of Imatinib Mesylate in Patients With Malignant Gastrointestinal Stromal Tumors (Extension Study)",
      "status": "COMPLETED",
      "last_update": "2012-05-01",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00237185",
      "title": "A Study of the Efficacy and Safety of Imatinib Mesylate in Patients With Unresectable or Metastatic Gastrointestinal Stromal Tumors Expressing C-kit Gene",
      "status": "COMPLETED",
      "last_update": "2014-08-19",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00254267",
      "title": "Evaluate the Efficacy of AMG 706 to Treat Advanced Gastrointestinal Stromal Tumors",
      "status": "COMPLETED",
      "last_update": "2014-02-27",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00265798",
      "title": "Sorafenib in Treating Patients With Malignant Gastrointestinal Stromal Tumor That Progressed During or After Previous Treatment With Imatinib Mesylate and Sunitinib Malate",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-09-09",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00278876",
      "title": "Adjuvant Imatinib in High-risk Gastrointestinal Stromal Tumor (GIST) With C-kit Mutation",
      "status": "COMPLETED",
      "last_update": "2020-01-07",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00290485",
      "title": "Gleevec Administered Preoperatively to Reduce Gastrointestinal Stromal Tumor (GIST)",
      "status": "UNKNOWN",
      "last_update": "2006-04-07",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00293124",
      "title": "Open-label Trial of GlivecWith Unresectable or Metastatic Malignant Gastrointestinal Stromal Tumors",
      "status": "COMPLETED",
      "last_update": "2015-08-13",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00324987",
      "title": "Imatinib Mesylate With or Without Bevacizumab in Treating Patients With Metastatic or Unresectable Gastrointestinal Stromal Tumor",
      "status": "TERMINATED",
      "last_update": "2017-09-14",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00359333",
      "title": "Phase II Trial of Locally Advanced/Metastatic Soft Tissue Sarcoma or Advanced/Metastatic Malignant GIST",
      "status": "COMPLETED",
      "last_update": "2013-10-30",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00367861",
      "title": "Prospective Multicentric Randomized Study of Glivec\u00ae in Advanced GIST Expressing C-kit: Interruption After 5 Years vs Maintenance",
      "status": "COMPLETED",
      "last_update": "2014-02-24",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00372567",
      "title": "Safety And Effectiveness Of Daily Dosing With Sunitinib Or Imatinib In Patients With Gastrointestinal Stromal Tumors",
      "status": "TERMINATED",
      "last_update": "2011-03-17",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00385203",
      "title": "The Biological Activity of Cediranib (AZD2171) in Gastro-Intestinal Stromal Tumours(GIST).",
      "status": "COMPLETED",
      "last_update": "2012-07-16",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00400569",
      "title": "Phase II Study of Sunitinib Malate for Metastatic and/or Surgically Unresectable Soft Tissue Sarcoma",
      "status": "COMPLETED",
      "last_update": "2012-08-28",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00428220",
      "title": "A Continuation Study Using Sunitinib Malate For Patients Leaving Treatment On A Previous Sunitinib Study.",
      "status": "COMPLETED",
      "last_update": "2019-06-27",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00441155",
      "title": "Patients Completing Core Protocol (CAMN107A2103), Exhibiting Stable Disease (SD), Partial Response (PR) or Complete Response (CR) to Nilotinib in Combination With Imatinib",
      "status": "COMPLETED",
      "last_update": "2013-05-13",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00455559",
      "title": "Ph II Study of Perifosine Plus Gleevec for Patients With GIST",
      "status": "COMPLETED",
      "last_update": "2018-02-22",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00457743",
      "title": "A Phase I/II Study of Sunitinib Malate (SU011248) In Patients With Gastrointestinal Stromal Tumor (GIST)",
      "status": "COMPLETED",
      "last_update": "2009-11-13",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00461929",
      "title": "Chromosome Abnormalities in Chronic Myeloid Leukemia (CML) on Imatinib. GIST Patients on Imatinib",
      "status": "TERMINATED",
      "last_update": "2009-02-13",
      "phase": "PHASE4",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00464620",
      "title": "Trial of Dasatinib in Advanced Sarcomas",
      "status": "COMPLETED",
      "last_update": "2018-11-23",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00471328",
      "title": "Efficacy and Safety of Nilotinib (AMN107) Compared With Current Treatment Options in Patients With GIST Who Have Failed Both Imatinib and Sunitinib",
      "status": "COMPLETED",
      "last_update": "2012-06-12",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00500188",
      "title": "Preoperative and Postoperative Imatinib Mesylate Study in Patients With c-Kit Positive GIST",
      "status": "COMPLETED",
      "last_update": "2011-08-08",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00510354",
      "title": "Treatment of Patients With Everolimus and Imatinib Mesylate Who Have Progressive Gastro Intestinal Stromal Tumors (GIST) and Are Resistant to Imatinib Mesylate",
      "status": "COMPLETED",
      "last_update": "2020-09-10",
      "phase": "PHASE4",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00568750",
      "title": "Dasatinib as First-Line Therapy in Treating Patients With Gastrointestinal Stromal Tumors",
      "status": "COMPLETED",
      "last_update": "2019-06-17",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00570635",
      "title": "A Phase 2 Study of XL820 in Adults With Advanced GIST Resistant to Imatinib and/or Sunitinib",
      "status": "COMPLETED",
      "last_update": "2013-06-07",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00573404",
      "title": "Imatinib Mesylate and Sunitinib in Treating Patients With Gastrointestinal Stromal Tumors",
      "status": "TERMINATED",
      "last_update": "2011-11-16",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00580281",
      "title": "Effect of Imatinib on Bone Metabolism in Patients With Chronic Myelogenous Leukemia or Gastrointestinal Stromal Tumors",
      "status": "COMPLETED",
      "last_update": "2013-10-24",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00585221",
      "title": "Study of Imatinib and Peginterferon \u03b1-2b in Gastrointestinal Stromal Tumor (GIST) Patients",
      "status": "TERMINATED",
      "last_update": "2017-02-10",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00618319",
      "title": "An Open-Label, 18FDG-PET Pharmacodynamic Assessment of the Effect of BIIB021 in Subjects With Gastrointestinal Stromal Tumors (GIST)",
      "status": "COMPLETED",
      "last_update": "2015-10-02",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00633295",
      "title": "Phase II Study Aiming to Evaluate the Efficacy and Safety of Nilotinib Patients With Gastrointestinal Stromal Tumors (GIST) Resistant or Intolerant to Imatinib and or to 2nd Line Tyrosine Kinas (TK) Inhibitor",
      "status": "COMPLETED",
      "last_update": "2017-06-22",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00685828",
      "title": "Imatinib Mesylate in Treating Patients With Unresectable or Metastatic Gastrointestinal Stromal Tumor",
      "status": "UNKNOWN",
      "last_update": "2014-07-04",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00688766",
      "title": "Study Evaluating IPI-504 in Patients With Gastrointestinal Stromal Tumors (GIST) Following Failure of at Least Imatinib and Sunitinib",
      "status": "TERMINATED",
      "last_update": "2012-12-11",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00718562",
      "title": "Efficacy and Safety of AMN107 in Patients With GastroIntestinal Stromal Tumors (GIST) Who Have Failed Both Imatinib and Sunitinib",
      "status": "COMPLETED",
      "last_update": "2017-02-23",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00751036",
      "title": "Nilotinib 800 Mg And Imatinib 800 Mg For The Treatment Of Patients With Gastrointestinal Stromal Tumors (Gist) Refractory To Imatinib 400 Mg",
      "status": "TERMINATED",
      "last_update": "2014-03-26",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00756509",
      "title": "Treatment of Patients With Metastatic or Unresectable Gastrointestinal Stromal Tumors in First Line With Nilotinib",
      "status": "COMPLETED",
      "last_update": "2026-07-16",
      "phase": "PHASE4",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00764595",
      "title": "Imatinib Mesylate in Treating Patients With Liver Metastasis From a Gastrointestinal Stromal Tumor",
      "status": "COMPLETED",
      "last_update": "2023-07-21",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00769782",
      "title": "Surgery in Treating Patients With Liver Metastasis From a Gastrointestinal Stromal Tumor",
      "status": "COMPLETED",
      "last_update": "2023-07-21",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00782834",
      "title": "Nilotinib in Advanced Gastrointestinal Stromal Tumors (GIST)",
      "status": "TERMINATED",
      "last_update": "2013-04-22",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00785785",
      "title": "A Study of Nilotinib Versus Imatinib in GIST Patients",
      "status": "COMPLETED",
      "last_update": "2016-06-16",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00793871",
      "title": "Safety And Efficacy Study Of Sunitinib Malate In Chinese Patients With Imatinib Resistant Or Intolerant Malignant Gastrointestinal Stromal Tumor",
      "status": "COMPLETED",
      "last_update": "2015-11-20",
      "phase": "PHASE4",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00812240",
      "title": "Masitinib in First Line Treatment of Gastro-Intestinal Stromal Tumor (GIST)",
      "status": "TERMINATED",
      "last_update": "2023-02-01",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00867113",
      "title": "Five Year Adjuvant Imatinib Mesylate (Gleevec\u00ae) in Gastrointestinal Stromal Tumor (GIST)",
      "status": "COMPLETED",
      "last_update": "2018-03-14",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00940563",
      "title": "A Prospective, Multicenter Study on Best Clinical Use of Imatinib in the Advanced Gastrointestinal Stromal Tumors",
      "status": "COMPLETED",
      "last_update": "2011-07-01",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00956072",
      "title": "Imatinib Mesylate With or Without Surgery in Treating Patients With Metastatic Gastrointestinal Stromal Tumor That is Responding to Imatinib Mesylate",
      "status": "TERMINATED",
      "last_update": "2012-09-24",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00998751",
      "title": "Masitinib in Locally Advanced/Metastatic Gastro-intestinal Stromal Tumour (GIST)",
      "status": "COMPLETED",
      "last_update": "2018-12-11",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01031628",
      "title": "Study of Dose Escalation Versus no Dose Escalation of Imatinib in Metastatic Gastrointestinal Stromal Tumors (GIST) Patients",
      "status": "TERMINATED",
      "last_update": "2013-09-09",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01039519",
      "title": "A Study Evaluating STA-9090 in Patients With Metastatic and/or Unresectable Gastrointestinal Stromal Tumor (GIST)",
      "status": "COMPLETED",
      "last_update": "2016-03-10",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01046487",
      "title": "Imatinib Mesylate And Cyclophosphamide In Metronomic Administration: Dose Escalation Study Of Imatinib Mesylate",
      "status": "COMPLETED",
      "last_update": "2026-03-13",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01054911",
      "title": "Evaluation of Patients With Bulky GIST Using Sunitinib",
      "status": "TERMINATED",
      "last_update": "2016-09-22",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01068769",
      "title": "Regorafenib in Patients With Metastatic and/or Unresectable Gastrointestinal Stromal Tumor",
      "status": "COMPLETED",
      "last_update": "2020-08-24",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01089595",
      "title": "Trial of Tasigna (Nilotinib) 400 mg Twice Daily Alone or With Gleevec (Imatinib Mesylate) 400 mg Daily for Patients With Advanced Gastrointestinal Stromal Tumor (GIST)",
      "status": "TERMINATED",
      "last_update": "2017-03-15",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01091207",
      "title": "Sorafenib for Imatinib/Sunitinib-failed GIST",
      "status": "COMPLETED",
      "last_update": "2012-01-20",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01110668",
      "title": "Evaluation of Nilotinib In Patients With Advanced Gastrointestinal Stromal Tumor (GIST)",
      "status": "COMPLETED",
      "last_update": "2017-02-28",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01114087",
      "title": "Impact of the Inhibitors of Tyrosine Kinase on the Male Fertility",
      "status": "COMPLETED",
      "last_update": "2011-03-29",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01151852",
      "title": "Rechallenge of Imatinib in GIST Having no Effective Treatment: RIGHT",
      "status": "COMPLETED",
      "last_update": "2020-01-14",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01172548",
      "title": "Safety and Efficacy Evaluation of Two Year Imatinib Treatment in Adjuvant Gastrointestinal Stromal Tumor (GIST)",
      "status": "COMPLETED",
      "last_update": "2017-05-31",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01267695",
      "title": "Perioperative Imatinib Mesylate in Treating Patients With Locally Advanced Gastrointestinal Stromal Tumor",
      "status": "COMPLETED",
      "last_update": "2015-02-03",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01270893",
      "title": "Tasigna Neoadjuvant Gastrointestinal Stromal Tumor (GIST)",
      "status": "WITHDRAWN",
      "last_update": "2012-08-02",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01270984",
      "title": "Study to Evaluate the Pharmacokinetic Characteristics of Luckyvec 400mg Tablet, in Healthy Subjects",
      "status": "COMPLETED",
      "last_update": "2012-10-31",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01271712",
      "title": "Study of Regorafenib as a 3rd-line or Beyond Treatment for Gastrointestinal Stromal Tumors (GIST)",
      "status": "COMPLETED",
      "last_update": "2021-01-29",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01275222",
      "title": "Everolimus in Combination With Imatinib in Patients With Glivec Refractory/Resistant Gastrointestinal Stromal Tumors",
      "status": "COMPLETED",
      "last_update": "2021-06-25",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01289028",
      "title": "Efficacy of Nilotinib in Adult Patients With Gastrointestinal Stromal Tumors Resistant to Imatinib and Sunitinib.",
      "status": "COMPLETED",
      "last_update": "2017-01-02",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01294202",
      "title": "A Study to Investigate the Safety and Efficacy of AT13387, Alone or in Combination With Imatinib, in Patients With GIST",
      "status": "COMPLETED",
      "last_update": "2024-08-02",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01323400",
      "title": "Efficacy of Pazopanib in Gastrointestinal Stromal Tumors (GIST)",
      "status": "COMPLETED",
      "last_update": "2016-02-25",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01381822",
      "title": "Dose-Escalation Study of TH-302 in Combination With Sunitinib to Treat Patients With Advanced Renal Cell Carcinoma,Gastrointestinal Stromal Tumors and Pancreatic Neuroendocrine Tumors",
      "status": "UNKNOWN",
      "last_update": "2014-04-21",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01389583",
      "title": "A Study of AUY922 for GIST(Gastrointestinal Stromal Tumor) Patients",
      "status": "UNKNOWN",
      "last_update": "2015-02-25",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01391611",
      "title": "Pazopanib in Imatinib Refractory or Intolerant Gastrointestinal Stromal Tumors (GIST)",
      "status": "TERMINATED",
      "last_update": "2017-04-07",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01396148",
      "title": "A Study of Sunitinib In Young Patients With Advanced Gastrointestinal Stromal Tumor",
      "status": "COMPLETED",
      "last_update": "2019-03-27",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01402089",
      "title": "Cytochrom p450 3A4 and 1A2 Phenotyping for the Individualization of Treatment With Sunitinib or Erlotinib in Cancer Patients",
      "status": "COMPLETED",
      "last_update": "2016-02-02",
      "phase": "PHASE4",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01440959",
      "title": "Dovitinib for Imatinib/Sumitinib-failed Gastrointestinal Stromal Tumors (GIST): TKI258",
      "status": "COMPLETED",
      "last_update": "2020-01-18",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01468688",
      "title": "A Dose-finding Study of a Combination of Imatinib and BKM120 in the Treatment of 3rd Line GIST Patients",
      "status": "COMPLETED",
      "last_update": "2020-12-21",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01478373",
      "title": "Efficacy and Safety of Dovitinib in Patients With Gastrointestinal Stromal Tumors Refractory and/or Intolerant to Imatinib",
      "status": "COMPLETED",
      "last_update": "2016-04-27",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01483014",
      "title": "Phase ll Study of Imatinib Mesylate for the Neoadjuvant Treatment of Patients With Gastrointestinal Stromal Tumors (GIST)",
      "status": "COMPLETED",
      "last_update": "2016-11-18",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01506336",
      "title": "Masitinib in Patients With Gastro-Intestinal Stromal Tumour Resistant to Imatinib",
      "status": "COMPLETED",
      "last_update": "2018-12-11",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01524848",
      "title": "Pazopanib in Advanced Gastrointestinal Stromal Tumors Refractory to Imatinib and Sunitinib",
      "status": "COMPLETED",
      "last_update": "2017-05-10",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01541709",
      "title": "Imatinib Dose Escalation to 800 mg/Day in Korean Patients With Metastatic or Unresectable GIST Harboring KIT Exon 9 Mutation: KENEDI",
      "status": "UNKNOWN",
      "last_update": "2024-01-02",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01643278",
      "title": "Dasatinib and Ipilimumab in Treating Patients With Gastrointestinal Stromal Tumors or Other Sarcomas That Cannot Be Removed by Surgery or Are Metastatic",
      "status": "COMPLETED",
      "last_update": "2017-01-10",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01694277",
      "title": "Masitinib in Patients With Gastrointestinal Stromal Tumour After Progression With Imatinib",
      "status": "COMPLETED",
      "last_update": "2020-12-08",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01735955",
      "title": "Study to Allow Access to Nilotinib for Patients Who Are on Nilotinib Treatment in a Novartis-sponsored Study",
      "status": "COMPLETED",
      "last_update": "2024-02-08",
      "phase": "PHASE4",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01735968",
      "title": "A Dose-finding Study of a Combination of Imatinib and BYL719 in the Treatment of 3rd Line GIST Patients",
      "status": "COMPLETED",
      "last_update": "2020-12-21",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01738139",
      "title": "Ipilimumab and Imatinib Mesylate in Advanced Cancer",
      "status": "COMPLETED",
      "last_update": "2024-03-21",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01742299",
      "title": "Study to Allow Access to Imatinib for Patients Who Are on Imatinib Treatment in a Novartis-sponsored Study and Are Benefiting From the Treatment as Judged by the Investigator",
      "status": "COMPLETED",
      "last_update": "2026-08-18",
      "phase": "PHASE4",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01743300",
      "title": "The Influence of Phenotype, Grapefruit Juice and Orange Juice on the Pharmacokinetics of Sunitinib in Cancer Patients",
      "status": "COMPLETED",
      "last_update": "2012-12-19",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01751919",
      "title": "A Clinical Trial to Compare the Pharmacokinetics of Imatinib Mesylate Tablet 400mg (1 Tablet) and Glivec Film-coated Tablet 100mg (4 Tablets)(Phase I)",
      "status": "COMPLETED",
      "last_update": "2014-10-01",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01863745",
      "title": "Nilotinib Roll-over Protocol for Patients in Novartis-sponsored Nilotinib Study and Benefiting From Nilotinib Treatment",
      "status": "COMPLETED",
      "last_update": "2024-08-19",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01874665",
      "title": "A Phase 2 Trial of Ponatinib in Participants With Metastatic and/or Unresectable Gastrointestinal Stromal Tumor",
      "status": "COMPLETED",
      "last_update": "2018-05-18",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01907607",
      "title": "Efficacy and Safety of PD-0332991 in Advanced Gastrointestinal Stromal Tumors Refractory to Imatinib and Sunitinib",
      "status": "COMPLETED",
      "last_update": "2025-08-24",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01991379",
      "title": "MEK162 in Combination With Imatinib Mesylate in Patients With Untreated Advanced Gastrointestinal Stromal Tumor (GIST)",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-12-04",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02009423",
      "title": "Masitinib in Patients With Localized, Primary GIST After Complete Surgery and With High Risk of Recurrence",
      "status": "TERMINATED",
      "last_update": "2018-12-14",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02103322",
      "title": "Comparative Bioequivalence Study in Adult Patients Suffering From Chronic Myeloid Leukemia & Gastrointestinal Stromal Tumor Under Fed Conditions",
      "status": "COMPLETED",
      "last_update": "2014-06-27",
      "phase": "PHASE2/PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02164240",
      "title": "Phase Ib Study of SUnitinib Alternating With REgorafenib in Patients With Metastatic and/or Unresectable GIST",
      "status": "COMPLETED",
      "last_update": "2021-06-14",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02185937",
      "title": "Influence of an Acidic Beverage on the Imatinib Exposure After Major Gastrectomy",
      "status": "TERMINATED",
      "last_update": "2020-12-08",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02216578",
      "title": "Ph II CABOGIST in GIST",
      "status": "COMPLETED",
      "last_update": "2021-07-15",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02257541",
      "title": "BGJ398 in Combination With Imatinib Mesylate in Patients With Untreated Advanced Gastrointestinal Stromal Tumor (GIST)",
      "status": "COMPLETED",
      "last_update": "2020-03-30",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02260505",
      "title": "Efficiency of Imatinib Treatment Maintenance or Interruption After 3 Years of Adjuvant Treatment in Patients With Gastrointestinal Stromal Tumours (GIST)",
      "status": "COMPLETED",
      "last_update": "2024-01-05",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02268435",
      "title": "Dovitinib in Combination With Imatinib in Patients With Gastrointestinal Stromal Tumors",
      "status": "WITHDRAWN",
      "last_update": "2015-08-04",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02342600",
      "title": "SARC029: Trametinib and Pazopanib in Patients With GIST (Gastrointestinal Stromal Tumor)",
      "status": "WITHDRAWN",
      "last_update": "2017-10-12",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02365441",
      "title": "A Randomised Trial of Imatinib Alternating With Regorafenib Compared to Imatinib Alone for the First Line Treatment of Advanced Gastrointestinal Stromal Tumour (GIST)",
      "status": "UNKNOWN",
      "last_update": "2023-07-07",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02401815",
      "title": "CGT9486 (Formerly Known as PLX9486) as a Single Agent and in Combination With PLX3397 (Pexidartinib) or Sunitinib in Participants With Advanced Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2025-02-14",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02508532",
      "title": "(NAVIGATOR) Study of BLU-285 in Patients With Gastrointestinal Stromal Tumors (GIST) and Other Relapsed and Refractory Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2022-06-21",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02571036",
      "title": "A Safety, Tolerability and PK Study of DCC-2618 in Patients With Advanced Malignancies",
      "status": "COMPLETED",
      "last_update": "2023-12-13",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02576080",
      "title": "Efficacy of Imatinib in Patients With Intermediate-risk Gastrointestinal Stromal Tumor With a High-risk Genomic Grade Index",
      "status": "UNKNOWN",
      "last_update": "2015-10-15",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02606097",
      "title": "Regorafenib in GIST With Secondary C-KIT Exon 17 Mutation",
      "status": "COMPLETED",
      "last_update": "2019-03-21",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02607332",
      "title": "Paclitaxel in Patients With Metastatic or Advanced Gastrointestinal Stromal Tumors (GIST) After Failure to Imatinib and Sunitinib",
      "status": "COMPLETED",
      "last_update": "2020-01-07",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02638766",
      "title": "Single Agent Regorafenib in First-line for Metastatic/Unresectable KIT/PDGFR Wild Type GIST",
      "status": "COMPLETED",
      "last_update": "2023-03-27",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02712112",
      "title": "A Study of Intermittent Dosing Schedule of Imatinib in Patients With Tyrosine Kinase Inhibitor Refractory GISTs",
      "status": "COMPLETED",
      "last_update": "2023-01-04",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02776878",
      "title": "A Clinical Trial Evaluating the Efficacy and Safety of Dasatinib in Refractory Metastatic GIST",
      "status": "UNKNOWN",
      "last_update": "2016-05-18",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02800330",
      "title": "The Effects of the Proton Pump Inhibitor Esomeprazole on the Bioavailability of Regorafenib",
      "status": "COMPLETED",
      "last_update": "2018-08-02",
      "phase": "PHASE4",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02889328",
      "title": "Phase II Study of Regorafenib Continuous Dosing of Regorafenib in Patients With GISTs",
      "status": "COMPLETED",
      "last_update": "2020-01-09",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02924714",
      "title": "SSG XXV: The Stop-GIST Trial; Discontinuation of Imatinib in Patients With Oligo-metastatic GIST",
      "status": "SUSPENDED",
      "last_update": "2022-02-18",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02931929",
      "title": "MITIGATE-NeoBOM: A Study to Evaluate 68Ga- NeoBOMB1 in Patients With Advanced TKI-treated GIST Using PET/CT",
      "status": "COMPLETED",
      "last_update": "2019-07-19",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03171389",
      "title": "POETIG Trial - POnatinib After rEsisTance to Imatinib in GIST",
      "status": "UNKNOWN",
      "last_update": "2017-05-31",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03291054",
      "title": "Epacadostat and Pembrolizumab in Patients With GIST",
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      "last_update": "2024-06-11",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03291288",
      "title": "Effect of Pexidartinib on the Way the Body Processes CYP3A4 and CYP2C9 Substrates (Pharmacokinetics)",
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      "last_update": "2021-05-14",
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      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT03353753",
      "title": "Phase 3 Study of DCC-2618 vs Placebo in Advanced GIST Patients Who Have Been Treated With Prior Anticancer Therapies",
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      "last_update": "2022-11-21",
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      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03426722",
      "title": "L-carnitine vs Placebo for the Treatment of Muscle Cramps After Imatinib in Gastrointestinal Stromal Tumors",
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      "last_update": "2020-07-13",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03440515",
      "title": "Management of Imatinib-associated Severe Skin Rash in Patients With Gastrointestinal Stromal Tumor",
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      "last_update": "2020-01-07",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03465722",
      "title": "(VOYAGER) Study of Avapritinib vs Regorafenib in Patients With Locally Advanced Unresectable or Metastatic GIST",
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      "last_update": "2022-10-06",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03609424",
      "title": "PDR001 Plus Imatinib for Metastatic or Unresectable GIST",
      "status": "COMPLETED",
      "last_update": "2023-01-03",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03673501",
      "title": "A Study of Ripretinib vs Sunitinib in Advanced GIST Patients After Treatment With Imatinib",
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      "last_update": "2026-02-05",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03862768",
      "title": "Role of Surgery in Patients With Focally Progressive Gastrointestinal Stromal Tumors (GISTs) After Imatinib Treatment",
      "status": "UNKNOWN",
      "last_update": "2019-03-05",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT03890731",
      "title": "A Clinical Study of Regorafenib in Participants Who Have Been Treated in Previous Bayer-sponsored Regorafenib Studies That Have Been Completed",
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      "last_update": "2024-04-02",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03944304",
      "title": "Paclitaxel in Patients With GIST With Low P-glycoprotein Expression After Failure of at Least Imatinib and Sunitinib, and Regorafenib.",
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      "last_update": "2026-04-03",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT04006769",
      "title": "Entacapone Combination With Imatinib for Treatment of GIST",
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      "last_update": "2023-10-18",
      "phase": "EARLY_PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04106024",
      "title": "Efficacy and Safety of Anlotinib in Patients With Advanced Gastrointestinal Stromal Tumor After Failure of Imatinib: a Prospective, Single Arm and Multicenter Trial",
      "status": "UNKNOWN",
      "last_update": "2019-09-26",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04138381",
      "title": "Selinexor as Single Agent and With Imatinib in Metastatic and/or Unresectable Gastrointestinal Stromal Tumors (SeliGIST)",
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      "last_update": "2023-03-27",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04193553",
      "title": "Multicentre Placebo-controlled Double-blinded Phase II Study of Lenvatinib Efficacy in Patients With Locally Advanced or Metastatic GIST (Gastrointestinal Stromal Tumor) After Imatinib/Sunitinib Failure",
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      "last_update": "2024-06-18",
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      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT04276415",
      "title": "DS-6157a in Participants With Advanced Gastrointestinal Stromal Tumor (GIST)",
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      "last_update": "2024-02-15",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04282980",
      "title": "A Study of DCC-2618 (Ripretinib) In Patients With With Advanced Gastrointestinal Stromal Tumors (GIST)",
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     {
      "nct": "NCT04409223",
      "title": "Efficacy and Safety of Famitinib Versus Sunitinib in the Treatment of Advanced Gastrointestinal Stromal Tumour Patients After Failure of Imatinib",
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      "last_update": "2024-02-09",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04530981",
      "title": "A Drug-Drug Interaction Study to Evaluate the Effect of Ripretinib on the Pharmacokinetics of a CYP2C8 Probe Substrate in Patients with Advanced GIST",
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      "last_update": "2024-09-19",
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      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04633122",
      "title": "A Study to Assess DCC-2618 and Sunitinib in Patients With Advanced GIST After Treatment With Imatinib",
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      "last_update": "2026-04-03",
      "phase": "PHASE2",
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     {
      "nct": "NCT04908176",
      "title": "A Drug-drug Interaction Study of Avapritinib and Midazolam",
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      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT05080621",
      "title": "Ripretinib in Combination With Binimetinib in Patients With Gastrointestinal Stromal Tumor (GIST)",
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      "last_update": "2022-01-05",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT05132738",
      "title": "Ripretinib Used for Resectable Metastatic GIST After Failure of Imatinib Therapy",
      "status": "UNKNOWN",
      "last_update": "2021-11-24",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT05160168",
      "title": "A Study of THE-630 in Patients With Advanced Gastrointestinal Stromal Tumors (GIST)",
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     {
      "nct": "NCT05245968",
      "title": "A Study of Pimitespib in Combination With Imatinib in Patients With GIST (CHAPTER-GIST-101)",
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     {
      "nct": "NCT05489237",
      "title": "First-in-human Study of IDRX-42 in Participants With Metastatic and/or Unresectable Gastrointestinal Stromal Tumors",
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     {
      "nct": "NCT05734105",
      "title": "A Study of Ripretinib vs Sunitinib in Patients With Advanced GIST With Specific KIT Exon Mutations Who Were Previously Treated With Imatinib",
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     {
      "nct": "NCT05800106",
      "title": "A Bioequivalence Study of Sunitinib Malate Capsules.",
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     {
      "nct": "NCT05970900",
      "title": "Preoperative Imatinib Mesylate Combined With Rectal-sparing Surgery in Patients With c-KIT Gene-mutant Rectal GIST",
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      "last_update": "2023-08-01",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06087263",
      "title": "Phase 2 Study to Evaluate the Efficacy of Regorafenib in Specific GIST Mutation Subsets (KIT Exon 17, 18, or 14 Mutation and SDHB Deficient GIST) in the Post-imatinib Second-line Setting.",
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     {
      "nct": "NCT06208748",
      "title": "SARC044: A Phase II Trial of Bezuclastinib in Combination With Sunitinib in Patients With GIST",
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     {
      "nct": "NCT06772233",
      "title": "A Study of Regorafenib Combined With Envafolimab for Metastatic Gastrointestinal Stromal Tumors With Kit Gene Exon 17 Mutation That Failed Standard Treatment",
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      "last_update": "2025-07-31",
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     {
      "nct": "NCT06856590",
      "title": "ZINCLO-HAND: Zinc and Clobetasol for the Prevention of Regorafenib-Induced Hand-Foot Skin Reaction",
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      "nct": "NCT06630234",
      "title": "A Master Protocol to Evaluate DCC-3009 in Gastrointestinal Stromal Tumor (GIST)",
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     {
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      "title": "Imatinib Mesylate in Treating Patients With Locally Advanced Gastrointestinal Stromal Tumor",
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     {
      "nct": "NCT00116935",
      "title": "Study Comparing 12 Months Versus 36 Months of Imatinib in the Treatment of Gastrointestinal Stromal Tumor (GIST)",
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     {
      "nct": "NCT01243346",
      "title": "Study of Crenolanib for the Treatment of Patients With Advanced GIST With the D842-related Mutations and Deletions in the PDGFRA Gene",
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      "nct": "NCT01462994",
      "title": "Detection of CF-DNA in Patients With Gastrointestinal Stromal Tumors (GIST)",
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     {
      "nct": "NCT02508532",
      "title": "(NAVIGATOR) Study of BLU-285 in Patients With Gastrointestinal Stromal Tumors (GIST) and Other Relapsed and Refractory Solid Tumors",
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     {
      "nct": "NCT02847429",
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      "title": "Phase 3 Study of DCC-2618 vs Placebo in Advanced GIST Patients Who Have Been Treated With Prior Anticancer Therapies",
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      "title": "(VOYAGER) Study of Avapritinib vs Regorafenib in Patients With Locally Advanced Unresectable or Metastatic GIST",
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      "nct": "NCT03673501",
      "title": "A Study of Ripretinib vs Sunitinib in Advanced GIST Patients After Treatment With Imatinib",
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      "nct": "NCT04254939",
      "title": "A Study of CS3007 in Subjects With Gastrointestinal Stromal Tumor",
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      "title": "Efficacy and Safety of Famitinib Versus Sunitinib in the Treatment of Advanced Gastrointestinal Stromal Tumour Patients After Failure of Imatinib",
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      "title": "A Drug-Drug Interaction Study to Evaluate the Effect of Ripretinib on the Pharmacokinetics of a CYP2C8 Probe Substrate in Patients with Advanced GIST",
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      "nct": "NCT04825574",
      "title": "Study for Patients Previously Treated in Avapritinib Clinical Trials",
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      "title": "A Study of THE-630 in Patients With Advanced Gastrointestinal Stromal Tumors (GIST)",
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      "nct": "NCT02452424",
      "title": "A Combination Clinical Study of PLX3397 and Pembrolizumab To Treat Advanced Melanoma and Other Solid Tumors",
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      "title": "Nivolumab With or Without Ipilimumab in Treating Patients With Metastatic Sarcoma That Cannot Be Removed by Surgery",
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      "nct": "NCT02880020",
      "title": "Nivolumab With or Without Ipilimumab in Treating Patients With Gastrointestinal Stromal Tumor That Is Metastatic or Cannot Be Removed by Surgery",
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      "nct": "NCT02982486",
      "title": "A Phase II of Nivolumab Plus Ipilimumab in Non-resectable Sarcoma and Endometrial Carcinoma",
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      "nct": "NCT03168139",
      "title": "Olaptesed (NOX-A12) Alone and in Combination With Pembrolizumab in Colorectal and Pancreatic Cancer",
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      "title": "Epacadostat and Pembrolizumab in Patients With GIST",
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      "nct": "NCT04000529",
      "title": "Phase Ib Study of TNO155 in Combination With Spartalizumab or Ribociclib in Selected Malignancies",
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      "title": "Dasatinib and Ipilimumab in Treating Patients With Gastrointestinal Stromal Tumors or Other Sarcomas That Cannot Be Removed by Surgery or Are Metastatic",
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      "nct": "NCT01738139",
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      "nct": "NCT02834013",
      "title": "Nivolumab and Ipilimumab in Treating Patients With Rare Tumors",
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      "nct": "NCT02880020",
      "title": "Nivolumab With or Without Ipilimumab in Treating Patients With Gastrointestinal Stromal Tumor That Is Metastatic or Cannot Be Removed by Surgery",
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      "nct": "NCT02982486",
      "title": "A Phase II of Nivolumab Plus Ipilimumab in Non-resectable Sarcoma and Endometrial Carcinoma",
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      "nct": "NCT01991379",
      "title": "MEK162 in Combination With Imatinib Mesylate in Patients With Untreated Advanced Gastrointestinal Stromal Tumor (GIST)",
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      "title": "Efficacy and Safety of the Combination Therapy of Dabrafenib and Trametinib in Subjects With BRAF V600E- Mutated Rare Cancers",
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      "title": "SARC029: Trametinib and Pazopanib in Patients With GIST (Gastrointestinal Stromal Tumor)",
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      "title": "Mitogen Activated Protein Kinase Kinase (MEK1/2) Inhibitor Selumetinib (AZD6244 Hydrogen Sulfate) in People With Neurofibromatosis Type 1 (NF1) Mutated Gastrointestinal Stromal Tumors (GIST)",
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      "title": "A Study of MEK162 (Binimetinib) in Combination With Pexidartinib in Patients With Advanced Gastrointestinal Stromal Tumor (GIST)",
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      "title": "Targeted Agent Evaluation in Digestive Cancers in China Based on Molecular Characteristics",
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      "title": "Efficacy and Safety of Famitinib Versus Sunitinib in the Treatment of Advanced Gastrointestinal Stromal Tumour Patients After Failure of Imatinib",
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      "title": "A Prospective, Randomized, Multicenter, Comparative Study of the Efficacy of Imatinib Resumption Combined With Atezolizumab Versus Imatinib Resumption Alone in Patients With Unresectable Advanced Gastrointestinal Stromal Tumors (GIST) After Failure of Standard Treatments",
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      "nct": "NCT05385549",
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      "title": "A Study of Ziftomenib in Combination With Imatinib in Patients With Advanced Gastrointestinal Stromal Tumors (GIST)",
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     {
      "nct": "NCT07096609",
      "title": "Lenvatinib After Progression on Imatinib, Sunitinib, and Regorafenib for GIST Patients",
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      "nct": "NCT07171203",
      "title": "Preoperative Imatinib and Fampridine in KIT Mutant Gastrointestinal Stromal Tumor",
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     {
      "nct": "NCT07218926",
      "title": "A Study of IDRX-42 (GSK6042981) Versus (vs) Sunitinib in Participants With Gastrointestinal Stromal Tumors After Imatinib Therapy",
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      "last_update": "2026-09-08",
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     {
      "nct": "NCT07406633",
      "title": "KQB198 in Combination With Imatinib in Participants With Advanced/Metastatic GIST in 1st Line Setting (SynerGIST-1st Line)",
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      "last_update": "2026-08-10",
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     {
      "nct": "NCT07585266",
      "title": "A Study to Investigate Velzatinib Compared With Imatinib in Adult Participants With Previously Untreated Metastatic and/or Unresectable Gastrointestinal Stromal Tumors (StrateGIST Frontline)",
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      "last_update": "2026-08-19",
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     {
      "nct": "NCT07689201",
      "title": "A Study of Velzatinib in Participants With Metastatic and/or Unresectable GIST After Imatinib, Sunitinib, Regorafenib, and Pimitespib",
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     {
      "nct": "NCT00006357",
      "title": "STI571 in Treating Patients With Recurrent or Refractory Soft Tissue Sarcoma",
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     {
      "nct": "NCT00009906",
      "title": "Comparison of Two Different Doses of STI571 in Treating Patients With Metastatic or Unresectable Gastrointestinal Stromal Tumor",
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     {
      "nct": "NCT00025246",
      "title": "Imatinib Mesylate in Treating Patients With Gastrointestinal Stromal Tumor That Has Been Completely Removed During Surgery",
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      "last_update": "2013-02-20",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00025415",
      "title": "Imatinib Mesylate in Treating Patients With Advanced Cancer and Liver Dysfunction",
      "status": "COMPLETED",
      "last_update": "2013-02-07",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00028002",
      "title": "Neoadjuvant and Adjuvant Imatinib Mesylate in Treating Patients With Primary or Recurrent Malignant Gastrointestinal Stromal Tumor",
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      "last_update": "2020-10-26",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00030667",
      "title": "Imatinib Mesylate in Treating Patients With Relapsed or Refractory Solid Tumors of Childhood",
      "status": "COMPLETED",
      "last_update": "2015-04-15",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00041197",
      "title": "Imatinib Mesylate in Treating Patients With Primary Gastrointestinal Stromal Tumor That Has Been Completely Removed By Surgery",
      "status": "COMPLETED",
      "last_update": "2013-07-16",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00075218",
      "title": "A Study To Assess The Safety And Efficacy Of SU11248 In Patients With Gastrointestinal Stromal Tumor(GIST)",
      "status": "COMPLETED",
      "last_update": "2009-09-28",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00089960",
      "title": "Study of AMG 706 in Subjects With Advanced Gastrointestinal Stromal Tumors (GISTs)",
      "status": "COMPLETED",
      "last_update": "2013-04-29",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00091078",
      "title": "Oblimersen and Imatinib Mesylate in Treating Patients With Advanced Gastrointestinal Stromal Tumors That Cannot Be Removed By Surgery",
      "status": "TERMINATED",
      "last_update": "2013-06-05",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00103168",
      "title": "Imatinib Mesylate or Observation Only in Treating Patients Who Have Undergone Surgery for Localized Gastrointestinal Stromal Tumor",
      "status": "COMPLETED",
      "last_update": "2018-07-09",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00112632",
      "title": "Imatinib Mesylate in Treating Patients With Locally Advanced Gastrointestinal Stromal Tumor",
      "status": "COMPLETED",
      "last_update": "2012-03-08",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00116935",
      "title": "Study Comparing 12 Months Versus 36 Months of Imatinib in the Treatment of Gastrointestinal Stromal Tumor (GIST)",
      "status": "COMPLETED",
      "last_update": "2011-12-30",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00117299",
      "title": "PTK787/ZK222584 in the Treatment of Metastatic Gastrointestinal Stromal Tumors Resistant to Imatinib",
      "status": "COMPLETED",
      "last_update": "2010-05-27",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00135005",
      "title": "Study of AMN107 With Imatinib in Gastrointestinal Stromal Tumors (GIST)",
      "status": "COMPLETED",
      "last_update": "2020-12-08",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00171912",
      "title": "Imatinib Mesylate in Patients With Various Types of Malignancies Involving Activated Tyrosine Kinase Enzymes",
      "status": "COMPLETED",
      "last_update": "2017-02-23",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00171977",
      "title": "Post-Marketing Clinical Study of Postoperative Adjuvant Therapy With Imatinib Mesylate in Patients With Gastrointestinal Stromal Tumors (GIST)",
      "status": "COMPLETED",
      "last_update": "2012-08-07",
      "phase": "PHASE4",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00237172",
      "title": "Phase II Clinical Study of Imatinib Mesylate in Patients With Malignant Gastrointestinal Stromal Tumors (Extension Study)",
      "status": "COMPLETED",
      "last_update": "2012-05-01",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00237185",
      "title": "A Study of the Efficacy and Safety of Imatinib Mesylate in Patients With Unresectable or Metastatic Gastrointestinal Stromal Tumors Expressing C-kit Gene",
      "status": "COMPLETED",
      "last_update": "2014-08-19",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00254267",
      "title": "Evaluate the Efficacy of AMG 706 to Treat Advanced Gastrointestinal Stromal Tumors",
      "status": "COMPLETED",
      "last_update": "2014-02-27",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00265798",
      "title": "Sorafenib in Treating Patients With Malignant Gastrointestinal Stromal Tumor That Progressed During or After Previous Treatment With Imatinib Mesylate and Sunitinib Malate",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-09-09",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00278876",
      "title": "Adjuvant Imatinib in High-risk Gastrointestinal Stromal Tumor (GIST) With C-kit Mutation",
      "status": "COMPLETED",
      "last_update": "2020-01-07",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00290485",
      "title": "Gleevec Administered Preoperatively to Reduce Gastrointestinal Stromal Tumor (GIST)",
      "status": "UNKNOWN",
      "last_update": "2006-04-07",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00293124",
      "title": "Open-label Trial of GlivecWith Unresectable or Metastatic Malignant Gastrointestinal Stromal Tumors",
      "status": "COMPLETED",
      "last_update": "2015-08-13",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00324987",
      "title": "Imatinib Mesylate With or Without Bevacizumab in Treating Patients With Metastatic or Unresectable Gastrointestinal Stromal Tumor",
      "status": "TERMINATED",
      "last_update": "2017-09-14",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00359333",
      "title": "Phase II Trial of Locally Advanced/Metastatic Soft Tissue Sarcoma or Advanced/Metastatic Malignant GIST",
      "status": "COMPLETED",
      "last_update": "2013-10-30",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00367861",
      "title": "Prospective Multicentric Randomized Study of Glivec\u00ae in Advanced GIST Expressing C-kit: Interruption After 5 Years vs Maintenance",
      "status": "COMPLETED",
      "last_update": "2014-02-24",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00372567",
      "title": "Safety And Effectiveness Of Daily Dosing With Sunitinib Or Imatinib In Patients With Gastrointestinal Stromal Tumors",
      "status": "TERMINATED",
      "last_update": "2011-03-17",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00385203",
      "title": "The Biological Activity of Cediranib (AZD2171) in Gastro-Intestinal Stromal Tumours(GIST).",
      "status": "COMPLETED",
      "last_update": "2012-07-16",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00400569",
      "title": "Phase II Study of Sunitinib Malate for Metastatic and/or Surgically Unresectable Soft Tissue Sarcoma",
      "status": "COMPLETED",
      "last_update": "2012-08-28",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00441155",
      "title": "Patients Completing Core Protocol (CAMN107A2103), Exhibiting Stable Disease (SD), Partial Response (PR) or Complete Response (CR) to Nilotinib in Combination With Imatinib",
      "status": "COMPLETED",
      "last_update": "2013-05-13",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00455559",
      "title": "Ph II Study of Perifosine Plus Gleevec for Patients With GIST",
      "status": "COMPLETED",
      "last_update": "2018-02-22",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00457743",
      "title": "A Phase I/II Study of Sunitinib Malate (SU011248) In Patients With Gastrointestinal Stromal Tumor (GIST)",
      "status": "COMPLETED",
      "last_update": "2009-11-13",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00461929",
      "title": "Chromosome Abnormalities in Chronic Myeloid Leukemia (CML) on Imatinib. GIST Patients on Imatinib",
      "status": "TERMINATED",
      "last_update": "2009-02-13",
      "phase": "PHASE4",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00471328",
      "title": "Efficacy and Safety of Nilotinib (AMN107) Compared With Current Treatment Options in Patients With GIST Who Have Failed Both Imatinib and Sunitinib",
      "status": "COMPLETED",
      "last_update": "2012-06-12",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00500188",
      "title": "Preoperative and Postoperative Imatinib Mesylate Study in Patients With c-Kit Positive GIST",
      "status": "COMPLETED",
      "last_update": "2011-08-08",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00510354",
      "title": "Treatment of Patients With Everolimus and Imatinib Mesylate Who Have Progressive Gastro Intestinal Stromal Tumors (GIST) and Are Resistant to Imatinib Mesylate",
      "status": "COMPLETED",
      "last_update": "2020-09-10",
      "phase": "PHASE4",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00570635",
      "title": "A Phase 2 Study of XL820 in Adults With Advanced GIST Resistant to Imatinib and/or Sunitinib",
      "status": "COMPLETED",
      "last_update": "2013-06-07",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00573404",
      "title": "Imatinib Mesylate and Sunitinib in Treating Patients With Gastrointestinal Stromal Tumors",
      "status": "TERMINATED",
      "last_update": "2011-11-16",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00580281",
      "title": "Effect of Imatinib on Bone Metabolism in Patients With Chronic Myelogenous Leukemia or Gastrointestinal Stromal Tumors",
      "status": "COMPLETED",
      "last_update": "2013-10-24",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00585221",
      "title": "Study of Imatinib and Peginterferon \u03b1-2b in Gastrointestinal Stromal Tumor (GIST) Patients",
      "status": "TERMINATED",
      "last_update": "2017-02-10",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00618319",
      "title": "An Open-Label, 18FDG-PET Pharmacodynamic Assessment of the Effect of BIIB021 in Subjects With Gastrointestinal Stromal Tumors (GIST)",
      "status": "COMPLETED",
      "last_update": "2015-10-02",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00633295",
      "title": "Phase II Study Aiming to Evaluate the Efficacy and Safety of Nilotinib Patients With Gastrointestinal Stromal Tumors (GIST) Resistant or Intolerant to Imatinib and or to 2nd Line Tyrosine Kinas (TK) Inhibitor",
      "status": "COMPLETED",
      "last_update": "2017-06-22",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00685828",
      "title": "Imatinib Mesylate in Treating Patients With Unresectable or Metastatic Gastrointestinal Stromal Tumor",
      "status": "UNKNOWN",
      "last_update": "2014-07-04",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00688766",
      "title": "Study Evaluating IPI-504 in Patients With Gastrointestinal Stromal Tumors (GIST) Following Failure of at Least Imatinib and Sunitinib",
      "status": "TERMINATED",
      "last_update": "2012-12-11",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00718562",
      "title": "Efficacy and Safety of AMN107 in Patients With GastroIntestinal Stromal Tumors (GIST) Who Have Failed Both Imatinib and Sunitinib",
      "status": "COMPLETED",
      "last_update": "2017-02-23",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00751036",
      "title": "Nilotinib 800 Mg And Imatinib 800 Mg For The Treatment Of Patients With Gastrointestinal Stromal Tumors (Gist) Refractory To Imatinib 400 Mg",
      "status": "TERMINATED",
      "last_update": "2014-03-26",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00764595",
      "title": "Imatinib Mesylate in Treating Patients With Liver Metastasis From a Gastrointestinal Stromal Tumor",
      "status": "COMPLETED",
      "last_update": "2023-07-21",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00769782",
      "title": "Surgery in Treating Patients With Liver Metastasis From a Gastrointestinal Stromal Tumor",
      "status": "COMPLETED",
      "last_update": "2023-07-21",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00782834",
      "title": "Nilotinib in Advanced Gastrointestinal Stromal Tumors (GIST)",
      "status": "TERMINATED",
      "last_update": "2013-04-22",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00785785",
      "title": "A Study of Nilotinib Versus Imatinib in GIST Patients",
      "status": "COMPLETED",
      "last_update": "2016-06-16",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00793871",
      "title": "Safety And Efficacy Study Of Sunitinib Malate In Chinese Patients With Imatinib Resistant Or Intolerant Malignant Gastrointestinal Stromal Tumor",
      "status": "COMPLETED",
      "last_update": "2015-11-20",
      "phase": "PHASE4",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00812240",
      "title": "Masitinib in First Line Treatment of Gastro-Intestinal Stromal Tumor (GIST)",
      "status": "TERMINATED",
      "last_update": "2023-02-01",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00867113",
      "title": "Five Year Adjuvant Imatinib Mesylate (Gleevec\u00ae) in Gastrointestinal Stromal Tumor (GIST)",
      "status": "COMPLETED",
      "last_update": "2018-03-14",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00940563",
      "title": "A Prospective, Multicenter Study on Best Clinical Use of Imatinib in the Advanced Gastrointestinal Stromal Tumors",
      "status": "COMPLETED",
      "last_update": "2011-07-01",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00956072",
      "title": "Imatinib Mesylate With or Without Surgery in Treating Patients With Metastatic Gastrointestinal Stromal Tumor That is Responding to Imatinib Mesylate",
      "status": "TERMINATED",
      "last_update": "2012-09-24",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01031628",
      "title": "Study of Dose Escalation Versus no Dose Escalation of Imatinib in Metastatic Gastrointestinal Stromal Tumors (GIST) Patients",
      "status": "TERMINATED",
      "last_update": "2013-09-09",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01039519",
      "title": "A Study Evaluating STA-9090 in Patients With Metastatic and/or Unresectable Gastrointestinal Stromal Tumor (GIST)",
      "status": "COMPLETED",
      "last_update": "2016-03-10",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01046487",
      "title": "Imatinib Mesylate And Cyclophosphamide In Metronomic Administration: Dose Escalation Study Of Imatinib Mesylate",
      "status": "COMPLETED",
      "last_update": "2026-03-13",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01068769",
      "title": "Regorafenib in Patients With Metastatic and/or Unresectable Gastrointestinal Stromal Tumor",
      "status": "COMPLETED",
      "last_update": "2020-08-24",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01089595",
      "title": "Trial of Tasigna (Nilotinib) 400 mg Twice Daily Alone or With Gleevec (Imatinib Mesylate) 400 mg Daily for Patients With Advanced Gastrointestinal Stromal Tumor (GIST)",
      "status": "TERMINATED",
      "last_update": "2017-03-15",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01091207",
      "title": "Sorafenib for Imatinib/Sunitinib-failed GIST",
      "status": "COMPLETED",
      "last_update": "2012-01-20",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01110668",
      "title": "Evaluation of Nilotinib In Patients With Advanced Gastrointestinal Stromal Tumor (GIST)",
      "status": "COMPLETED",
      "last_update": "2017-02-28",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01114087",
      "title": "Impact of the Inhibitors of Tyrosine Kinase on the Male Fertility",
      "status": "COMPLETED",
      "last_update": "2011-03-29",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01151852",
      "title": "Rechallenge of Imatinib in GIST Having no Effective Treatment: RIGHT",
      "status": "COMPLETED",
      "last_update": "2020-01-14",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01172548",
      "title": "Safety and Efficacy Evaluation of Two Year Imatinib Treatment in Adjuvant Gastrointestinal Stromal Tumor (GIST)",
      "status": "COMPLETED",
      "last_update": "2017-05-31",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01267695",
      "title": "Perioperative Imatinib Mesylate in Treating Patients With Locally Advanced Gastrointestinal Stromal Tumor",
      "status": "COMPLETED",
      "last_update": "2015-02-03",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01270984",
      "title": "Study to Evaluate the Pharmacokinetic Characteristics of Luckyvec 400mg Tablet, in Healthy Subjects",
      "status": "COMPLETED",
      "last_update": "2012-10-31",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01271712",
      "title": "Study of Regorafenib as a 3rd-line or Beyond Treatment for Gastrointestinal Stromal Tumors (GIST)",
      "status": "COMPLETED",
      "last_update": "2021-01-29",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01275222",
      "title": "Everolimus in Combination With Imatinib in Patients With Glivec Refractory/Resistant Gastrointestinal Stromal Tumors",
      "status": "COMPLETED",
      "last_update": "2021-06-25",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01289028",
      "title": "Efficacy of Nilotinib in Adult Patients With Gastrointestinal Stromal Tumors Resistant to Imatinib and Sunitinib.",
      "status": "COMPLETED",
      "last_update": "2017-01-02",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01294202",
      "title": "A Study to Investigate the Safety and Efficacy of AT13387, Alone or in Combination With Imatinib, in Patients With GIST",
      "status": "COMPLETED",
      "last_update": "2024-08-02",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01323400",
      "title": "Efficacy of Pazopanib in Gastrointestinal Stromal Tumors (GIST)",
      "status": "COMPLETED",
      "last_update": "2016-02-25",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01389583",
      "title": "A Study of AUY922 for GIST(Gastrointestinal Stromal Tumor) Patients",
      "status": "UNKNOWN",
      "last_update": "2015-02-25",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01391611",
      "title": "Pazopanib in Imatinib Refractory or Intolerant Gastrointestinal Stromal Tumors (GIST)",
      "status": "TERMINATED",
      "last_update": "2017-04-07",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01440959",
      "title": "Dovitinib for Imatinib/Sumitinib-failed Gastrointestinal Stromal Tumors (GIST): TKI258",
      "status": "COMPLETED",
      "last_update": "2020-01-18",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01468688",
      "title": "A Dose-finding Study of a Combination of Imatinib and BKM120 in the Treatment of 3rd Line GIST Patients",
      "status": "COMPLETED",
      "last_update": "2020-12-21",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01478373",
      "title": "Efficacy and Safety of Dovitinib in Patients With Gastrointestinal Stromal Tumors Refractory and/or Intolerant to Imatinib",
      "status": "COMPLETED",
      "last_update": "2016-04-27",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01483014",
      "title": "Phase ll Study of Imatinib Mesylate for the Neoadjuvant Treatment of Patients With Gastrointestinal Stromal Tumors (GIST)",
      "status": "COMPLETED",
      "last_update": "2016-11-18",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01506336",
      "title": "Masitinib in Patients With Gastro-Intestinal Stromal Tumour Resistant to Imatinib",
      "status": "COMPLETED",
      "last_update": "2018-12-11",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01524848",
      "title": "Pazopanib in Advanced Gastrointestinal Stromal Tumors Refractory to Imatinib and Sunitinib",
      "status": "COMPLETED",
      "last_update": "2017-05-10",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01541709",
      "title": "Imatinib Dose Escalation to 800 mg/Day in Korean Patients With Metastatic or Unresectable GIST Harboring KIT Exon 9 Mutation: KENEDI",
      "status": "UNKNOWN",
      "last_update": "2024-01-02",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01694277",
      "title": "Masitinib in Patients With Gastrointestinal Stromal Tumour After Progression With Imatinib",
      "status": "COMPLETED",
      "last_update": "2020-12-08",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01735968",
      "title": "A Dose-finding Study of a Combination of Imatinib and BYL719 in the Treatment of 3rd Line GIST Patients",
      "status": "COMPLETED",
      "last_update": "2020-12-21",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01738139",
      "title": "Ipilimumab and Imatinib Mesylate in Advanced Cancer",
      "status": "COMPLETED",
      "last_update": "2024-03-21",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01742299",
      "title": "Study to Allow Access to Imatinib for Patients Who Are on Imatinib Treatment in a Novartis-sponsored Study and Are Benefiting From the Treatment as Judged by the Investigator",
      "status": "COMPLETED",
      "last_update": "2026-08-18",
      "phase": "PHASE4",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01743300",
      "title": "The Influence of Phenotype, Grapefruit Juice and Orange Juice on the Pharmacokinetics of Sunitinib in Cancer Patients",
      "status": "COMPLETED",
      "last_update": "2012-12-19",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01751919",
      "title": "A Clinical Trial to Compare the Pharmacokinetics of Imatinib Mesylate Tablet 400mg (1 Tablet) and Glivec Film-coated Tablet 100mg (4 Tablets)(Phase I)",
      "status": "COMPLETED",
      "last_update": "2014-10-01",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01907607",
      "title": "Efficacy and Safety of PD-0332991 in Advanced Gastrointestinal Stromal Tumors Refractory to Imatinib and Sunitinib",
      "status": "COMPLETED",
      "last_update": "2025-08-24",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01991379",
      "title": "MEK162 in Combination With Imatinib Mesylate in Patients With Untreated Advanced Gastrointestinal Stromal Tumor (GIST)",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-12-04",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02103322",
      "title": "Comparative Bioequivalence Study in Adult Patients Suffering From Chronic Myeloid Leukemia & Gastrointestinal Stromal Tumor Under Fed Conditions",
      "status": "COMPLETED",
      "last_update": "2014-06-27",
      "phase": "PHASE2/PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02185937",
      "title": "Influence of an Acidic Beverage on the Imatinib Exposure After Major Gastrectomy",
      "status": "TERMINATED",
      "last_update": "2020-12-08",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02216578",
      "title": "Ph II CABOGIST in GIST",
      "status": "COMPLETED",
      "last_update": "2021-07-15",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02257541",
      "title": "BGJ398 in Combination With Imatinib Mesylate in Patients With Untreated Advanced Gastrointestinal Stromal Tumor (GIST)",
      "status": "COMPLETED",
      "last_update": "2020-03-30",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02260505",
      "title": "Efficiency of Imatinib Treatment Maintenance or Interruption After 3 Years of Adjuvant Treatment in Patients With Gastrointestinal Stromal Tumours (GIST)",
      "status": "COMPLETED",
      "last_update": "2024-01-05",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02268435",
      "title": "Dovitinib in Combination With Imatinib in Patients With Gastrointestinal Stromal Tumors",
      "status": "WITHDRAWN",
      "last_update": "2015-08-04",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02342600",
      "title": "SARC029: Trametinib and Pazopanib in Patients With GIST (Gastrointestinal Stromal Tumor)",
      "status": "WITHDRAWN",
      "last_update": "2017-10-12",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02365441",
      "title": "A Randomised Trial of Imatinib Alternating With Regorafenib Compared to Imatinib Alone for the First Line Treatment of Advanced Gastrointestinal Stromal Tumour (GIST)",
      "status": "UNKNOWN",
      "last_update": "2023-07-07",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02401815",
      "title": "CGT9486 (Formerly Known as PLX9486) as a Single Agent and in Combination With PLX3397 (Pexidartinib) or Sunitinib in Participants With Advanced Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2025-02-14",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02508532",
      "title": "(NAVIGATOR) Study of BLU-285 in Patients With Gastrointestinal Stromal Tumors (GIST) and Other Relapsed and Refractory Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2022-06-21",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02576080",
      "title": "Efficacy of Imatinib in Patients With Intermediate-risk Gastrointestinal Stromal Tumor With a High-risk Genomic Grade Index",
      "status": "UNKNOWN",
      "last_update": "2015-10-15",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02607332",
      "title": "Paclitaxel in Patients With Metastatic or Advanced Gastrointestinal Stromal Tumors (GIST) After Failure to Imatinib and Sunitinib",
      "status": "COMPLETED",
      "last_update": "2020-01-07",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02712112",
      "title": "A Study of Intermittent Dosing Schedule of Imatinib in Patients With Tyrosine Kinase Inhibitor Refractory GISTs",
      "status": "COMPLETED",
      "last_update": "2023-01-04",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02889328",
      "title": "Phase II Study of Regorafenib Continuous Dosing of Regorafenib in Patients With GISTs",
      "status": "COMPLETED",
      "last_update": "2020-01-09",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02924714",
      "title": "SSG XXV: The Stop-GIST Trial; Discontinuation of Imatinib in Patients With Oligo-metastatic GIST",
      "status": "SUSPENDED",
      "last_update": "2022-02-18",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03171389",
      "title": "POETIG Trial - POnatinib After rEsisTance to Imatinib in GIST",
      "status": "UNKNOWN",
      "last_update": "2017-05-31",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03291054",
      "title": "Epacadostat and Pembrolizumab in Patients With GIST",
      "status": "TERMINATED",
      "last_update": "2024-06-11",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03426722",
      "title": "L-carnitine vs Placebo for the Treatment of Muscle Cramps After Imatinib in Gastrointestinal Stromal Tumors",
      "status": "COMPLETED",
      "last_update": "2020-07-13",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03440515",
      "title": "Management of Imatinib-associated Severe Skin Rash in Patients With Gastrointestinal Stromal Tumor",
      "status": "COMPLETED",
      "last_update": "2020-01-07",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03465722",
      "title": "(VOYAGER) Study of Avapritinib vs Regorafenib in Patients With Locally Advanced Unresectable or Metastatic GIST",
      "status": "COMPLETED",
      "last_update": "2022-10-06",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03609424",
      "title": "PDR001 Plus Imatinib for Metastatic or Unresectable GIST",
      "status": "COMPLETED",
      "last_update": "2023-01-03",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03673501",
      "title": "A Study of Ripretinib vs Sunitinib in Advanced GIST Patients After Treatment With Imatinib",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-02-05",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03862768",
      "title": "Role of Surgery in Patients With Focally Progressive Gastrointestinal Stromal Tumors (GISTs) After Imatinib Treatment",
      "status": "UNKNOWN",
      "last_update": "2019-03-05",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03944304",
      "title": "Paclitaxel in Patients With GIST With Low P-glycoprotein Expression After Failure of at Least Imatinib and Sunitinib, and Regorafenib.",
      "status": "COMPLETED",
      "last_update": "2026-04-03",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04006769",
      "title": "Entacapone Combination With Imatinib for Treatment of GIST",
      "status": "COMPLETED",
      "last_update": "2023-10-18",
      "phase": "EARLY_PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04106024",
      "title": "Efficacy and Safety of Anlotinib in Patients With Advanced Gastrointestinal Stromal Tumor After Failure of Imatinib: a Prospective, Single Arm and Multicenter Trial",
      "status": "UNKNOWN",
      "last_update": "2019-09-26",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04138381",
      "title": "Selinexor as Single Agent and With Imatinib in Metastatic and/or Unresectable Gastrointestinal Stromal Tumors (SeliGIST)",
      "status": "UNKNOWN",
      "last_update": "2023-03-27",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04193553",
      "title": "Multicentre Placebo-controlled Double-blinded Phase II Study of Lenvatinib Efficacy in Patients With Locally Advanced or Metastatic GIST (Gastrointestinal Stromal Tumor) After Imatinib/Sunitinib Failure",
      "status": "COMPLETED",
      "last_update": "2024-06-18",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04276415",
      "title": "DS-6157a in Participants With Advanced Gastrointestinal Stromal Tumor (GIST)",
      "status": "TERMINATED",
      "last_update": "2024-02-15",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04409223",
      "title": "Efficacy and Safety of Famitinib Versus Sunitinib in the Treatment of Advanced Gastrointestinal Stromal Tumour Patients After Failure of Imatinib",
      "status": "TERMINATED",
      "last_update": "2024-02-09",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04633122",
      "title": "A Study to Assess DCC-2618 and Sunitinib in Patients With Advanced GIST After Treatment With Imatinib",
      "status": "COMPLETED",
      "last_update": "2026-04-03",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05080621",
      "title": "Ripretinib in Combination With Binimetinib in Patients With Gastrointestinal Stromal Tumor (GIST)",
      "status": "WITHDRAWN",
      "last_update": "2022-01-05",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05132738",
      "title": "Ripretinib Used for Resectable Metastatic GIST After Failure of Imatinib Therapy",
      "status": "UNKNOWN",
      "last_update": "2021-11-24",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05160168",
      "title": "A Study of THE-630 in Patients With Advanced Gastrointestinal Stromal Tumors (GIST)",
      "status": "TERMINATED",
      "last_update": "2024-06-05",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05245968",
      "title": "A Study of Pimitespib in Combination With Imatinib in Patients With GIST (CHAPTER-GIST-101)",
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      "last_update": "2026-01-20",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05489237",
      "title": "First-in-human Study of IDRX-42 in Participants With Metastatic and/or Unresectable Gastrointestinal Stromal Tumors",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-07-02",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05734105",
      "title": "A Study of Ripretinib vs Sunitinib in Patients With Advanced GIST With Specific KIT Exon Mutations Who Were Previously Treated With Imatinib",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-12-17",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05970900",
      "title": "Preoperative Imatinib Mesylate Combined With Rectal-sparing Surgery in Patients With c-KIT Gene-mutant Rectal GIST",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2023-08-01",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06087263",
      "title": "Phase 2 Study to Evaluate the Efficacy of Regorafenib in Specific GIST Mutation Subsets (KIT Exon 17, 18, or 14 Mutation and SDHB Deficient GIST) in the Post-imatinib Second-line Setting.",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-07-16",
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      "study_type": "INTERVENTIONAL"
     }
    ]
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     {
      "nct": "NCT00812240",
      "title": "Masitinib in First Line Treatment of Gastro-Intestinal Stromal Tumor (GIST)",
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      "last_update": "2023-02-01",
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      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00998751",
      "title": "Masitinib in Locally Advanced/Metastatic Gastro-intestinal Stromal Tumour (GIST)",
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      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT01506336",
      "title": "Masitinib in Patients With Gastro-Intestinal Stromal Tumour Resistant to Imatinib",
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      "last_update": "2018-12-11",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT01694277",
      "title": "Masitinib in Patients With Gastrointestinal Stromal Tumour After Progression With Imatinib",
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      "last_update": "2020-12-08",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT02009423",
      "title": "Masitinib in Patients With Localized, Primary GIST After Complete Surgery and With High Risk of Recurrence",
      "status": "TERMINATED",
      "last_update": "2018-12-14",
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      "nct": "NCT00089960",
      "title": "Study of AMG 706 in Subjects With Advanced Gastrointestinal Stromal Tumors (GISTs)",
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      "last_update": "2013-04-29",
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      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00254267",
      "title": "Evaluate the Efficacy of AMG 706 to Treat Advanced Gastrointestinal Stromal Tumors",
      "status": "COMPLETED",
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      "nct": "NCT01316263",
      "title": "A Study of Olaratumab (IMC-3G3) in Previously Treated Participants With Unresectable and/or Metastatic Gastrointestinal Stromal Tumors",
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     {
      "nct": "NCT00513851",
      "title": "Phase 1 Study of OSI-930 in Cancer Patients",
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      "nct": "NCT01323400",
      "title": "Efficacy of Pazopanib in Gastrointestinal Stromal Tumors (GIST)",
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     {
      "nct": "NCT01391611",
      "title": "Pazopanib in Imatinib Refractory or Intolerant Gastrointestinal Stromal Tumors (GIST)",
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      "last_update": "2017-04-07",
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     {
      "nct": "NCT01524848",
      "title": "Pazopanib in Advanced Gastrointestinal Stromal Tumors Refractory to Imatinib and Sunitinib",
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      "last_update": "2017-05-10",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT02342600",
      "title": "SARC029: Trametinib and Pazopanib in Patients With GIST (Gastrointestinal Stromal Tumor)",
      "status": "WITHDRAWN",
      "last_update": "2017-10-12",
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      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT02401815",
      "title": "CGT9486 (Formerly Known as PLX9486) as a Single Agent and in Combination With PLX3397 (Pexidartinib) or Sunitinib in Participants With Advanced Solid Tumors",
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     },
     {
      "nct": "NCT02452424",
      "title": "A Combination Clinical Study of PLX3397 and Pembrolizumab To Treat Advanced Melanoma and Other Solid Tumors",
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      "phase": "PHASE1/PHASE2",
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     {
      "nct": "NCT03158103",
      "title": "A Study of MEK162 (Binimetinib) in Combination With Pexidartinib in Patients With Advanced Gastrointestinal Stromal Tumor (GIST)",
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      "last_update": "2021-04-30",
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     {
      "nct": "NCT03291288",
      "title": "Effect of Pexidartinib on the Way the Body Processes CYP3A4 and CYP2C9 Substrates (Pharmacokinetics)",
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      "last_update": "2021-05-14",
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      "nct": "NCT05503797",
      "title": "A Study to Assess the Efficacy and Safety of FORE8394 in Participants With Cancer Harboring BRAF Alterations",
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      "last_update": "2026-07-27",
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      "nct": "NCT05366816",
      "title": "ctDNA-Guided Sunitinib And Regorafenib Therapy for GIST",
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      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT05905887",
      "title": "Rivoceranib Plus Paclitaxel in Patients With Gastrointestinal Stromal Tumor",
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      "last_update": "2026-04-07",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06326346",
      "title": "GIST Oral Paclitaxel(Liporaxel)",
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      "last_update": "2026-04-07",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT07096609",
      "title": "Lenvatinib After Progression on Imatinib, Sunitinib, and Regorafenib for GIST Patients",
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      "last_update": "2026-04-03",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT07379047",
      "title": "Efficacy and Safety of NB003 in Patients With Advanced Gastrointestinal Stromal Tumors (GIST)",
      "status": "RECRUITING",
      "last_update": "2026-06-10",
      "phase": "PHASE2/PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07559864",
      "title": "Comparing Regorafenib Combined With Envafolimab to Physician's Choice in Patients With Metastatic Gastrointestinal Stromal Tumors Harboring KIT Exon 17 Mutations Refractory to Standard Treatment",
      "status": "RECRUITING",
      "last_update": "2026-04-30",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07689201",
      "title": "A Study of Velzatinib in Participants With Metastatic and/or Unresectable GIST After Imatinib, Sunitinib, Regorafenib, and Pimitespib",
      "status": "RECRUITING",
      "last_update": "2026-09-09",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01068769",
      "title": "Regorafenib in Patients With Metastatic and/or Unresectable Gastrointestinal Stromal Tumor",
      "status": "COMPLETED",
      "last_update": "2020-08-24",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01271712",
      "title": "Study of Regorafenib as a 3rd-line or Beyond Treatment for Gastrointestinal Stromal Tumors (GIST)",
      "status": "COMPLETED",
      "last_update": "2021-01-29",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02164240",
      "title": "Phase Ib Study of SUnitinib Alternating With REgorafenib in Patients With Metastatic and/or Unresectable GIST",
      "status": "COMPLETED",
      "last_update": "2021-06-14",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02365441",
      "title": "A Randomised Trial of Imatinib Alternating With Regorafenib Compared to Imatinib Alone for the First Line Treatment of Advanced Gastrointestinal Stromal Tumour (GIST)",
      "status": "UNKNOWN",
      "last_update": "2023-07-07",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02606097",
      "title": "Regorafenib in GIST With Secondary C-KIT Exon 17 Mutation",
      "status": "COMPLETED",
      "last_update": "2019-03-21",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02638766",
      "title": "Single Agent Regorafenib in First-line for Metastatic/Unresectable KIT/PDGFR Wild Type GIST",
      "status": "COMPLETED",
      "last_update": "2023-03-27",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02800330",
      "title": "The Effects of the Proton Pump Inhibitor Esomeprazole on the Bioavailability of Regorafenib",
      "status": "COMPLETED",
      "last_update": "2018-08-02",
      "phase": "PHASE4",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02889328",
      "title": "Phase II Study of Regorafenib Continuous Dosing of Regorafenib in Patients With GISTs",
      "status": "COMPLETED",
      "last_update": "2020-01-09",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03171389",
      "title": "POETIG Trial - POnatinib After rEsisTance to Imatinib in GIST",
      "status": "UNKNOWN",
      "last_update": "2017-05-31",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03465722",
      "title": "(VOYAGER) Study of Avapritinib vs Regorafenib in Patients With Locally Advanced Unresectable or Metastatic GIST",
      "status": "COMPLETED",
      "last_update": "2022-10-06",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03609424",
      "title": "PDR001 Plus Imatinib for Metastatic or Unresectable GIST",
      "status": "COMPLETED",
      "last_update": "2023-01-03",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03890731",
      "title": "A Clinical Study of Regorafenib in Participants Who Have Been Treated in Previous Bayer-sponsored Regorafenib Studies That Have Been Completed",
      "status": "COMPLETED",
      "last_update": "2024-04-02",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03944304",
      "title": "Paclitaxel in Patients With GIST With Low P-glycoprotein Expression After Failure of at Least Imatinib and Sunitinib, and Regorafenib.",
      "status": "COMPLETED",
      "last_update": "2026-04-03",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05160168",
      "title": "A Study of THE-630 in Patients With Advanced Gastrointestinal Stromal Tumors (GIST)",
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      "last_update": "2024-06-05",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05489237",
      "title": "First-in-human Study of IDRX-42 in Participants With Metastatic and/or Unresectable Gastrointestinal Stromal Tumors",
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      "last_update": "2026-07-02",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06087263",
      "title": "Phase 2 Study to Evaluate the Efficacy of Regorafenib in Specific GIST Mutation Subsets (KIT Exon 17, 18, or 14 Mutation and SDHB Deficient GIST) in the Post-imatinib Second-line Setting.",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-07-16",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06772233",
      "title": "A Study of Regorafenib Combined With Envafolimab for Metastatic Gastrointestinal Stromal Tumors With Kit Gene Exon 17 Mutation That Failed Standard Treatment",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2025-07-31",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06856590",
      "title": "ZINCLO-HAND: Zinc and Clobetasol for the Prevention of Regorafenib-Induced Hand-Foot Skin Reaction",
      "status": "COMPLETED",
      "last_update": "2025-09-15",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     }
    ]
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   "RIPRETINIB": {
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     {
      "nct": "NCT05957367",
      "title": "A Study of Inlexisertib (DCC-3116) in Combination With Anticancer Therapies in Participants With Advanced Malignancies",
      "status": "RECRUITING",
      "last_update": "2026-07-23",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06507683",
      "title": "Evaluate the Efficacy and Safety of Radiotherapy Combined With Ripretinib in the Treatment of Unresectable Advanced GIST",
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      "last_update": "2024-07-18",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT02571036",
      "title": "A Safety, Tolerability and PK Study of DCC-2618 in Patients With Advanced Malignancies",
      "status": "COMPLETED",
      "last_update": "2023-12-13",
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      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT03353753",
      "title": "Phase 3 Study of DCC-2618 vs Placebo in Advanced GIST Patients Who Have Been Treated With Prior Anticancer Therapies",
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      "last_update": "2022-11-21",
      "phase": "PHASE3",
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     {
      "nct": "NCT03673501",
      "title": "A Study of Ripretinib vs Sunitinib in Advanced GIST Patients After Treatment With Imatinib",
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      "last_update": "2026-02-05",
      "phase": "PHASE3",
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     {
      "nct": "NCT04282980",
      "title": "A Study of DCC-2618 (Ripretinib) In Patients With With Advanced Gastrointestinal Stromal Tumors (GIST)",
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      "last_update": "2025-03-03",
      "phase": "PHASE2",
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     },
     {
      "nct": "NCT04530981",
      "title": "A Drug-Drug Interaction Study to Evaluate the Effect of Ripretinib on the Pharmacokinetics of a CYP2C8 Probe Substrate in Patients with Advanced GIST",
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      "last_update": "2024-09-19",
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     {
      "nct": "NCT04633122",
      "title": "A Study to Assess DCC-2618 and Sunitinib in Patients With Advanced GIST After Treatment With Imatinib",
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      "last_update": "2026-04-03",
      "phase": "PHASE2",
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     {
      "nct": "NCT05080621",
      "title": "Ripretinib in Combination With Binimetinib in Patients With Gastrointestinal Stromal Tumor (GIST)",
      "status": "WITHDRAWN",
      "last_update": "2022-01-05",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05132738",
      "title": "Ripretinib Used for Resectable Metastatic GIST After Failure of Imatinib Therapy",
      "status": "UNKNOWN",
      "last_update": "2021-11-24",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05160168",
      "title": "A Study of THE-630 in Patients With Advanced Gastrointestinal Stromal Tumors (GIST)",
      "status": "TERMINATED",
      "last_update": "2024-06-05",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05489237",
      "title": "First-in-human Study of IDRX-42 in Participants With Metastatic and/or Unresectable Gastrointestinal Stromal Tumors",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-07-02",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05734105",
      "title": "A Study of Ripretinib vs Sunitinib in Patients With Advanced GIST With Specific KIT Exon Mutations Who Were Previously Treated With Imatinib",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-12-17",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     }
    ]
   },
   "SEMAXANIB": {
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     {
      "nct": "NCT00005862",
      "title": "SU5416 in Treating Patients With Advanced, Metastatic, or Recurrent Soft Tissue Sarcomas",
      "status": "COMPLETED",
      "last_update": "2013-02-11",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     }
    ]
   },
   "SORAFENIB": {
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     {
      "nct": "NCT00265798",
      "title": "Sorafenib in Treating Patients With Malignant Gastrointestinal Stromal Tumor That Progressed During or After Previous Treatment With Imatinib Mesylate and Sunitinib Malate",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-09-09",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01091207",
      "title": "Sorafenib for Imatinib/Sunitinib-failed GIST",
      "status": "COMPLETED",
      "last_update": "2012-01-20",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     }
    ]
   },
   "SUNITINIB": {
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     {
      "nct": "NCT05208047",
      "title": "(Peak) A Phase 3 Randomized Trial of CGT9486+Sunitinib vs. Sunitinib in Subjects With Gastrointestinal Stromal Tumors",
      "status": "RECRUITING",
      "last_update": "2026-06-16",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05366816",
      "title": "ctDNA-Guided Sunitinib And Regorafenib Therapy for GIST",
      "status": "RECRUITING",
      "last_update": "2025-09-09",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05751733",
      "title": "Apatinib Mesylate Versus Standard Second-line TKI in the Treatment of Advanced GIST",
      "status": "RECRUITING",
      "last_update": "2023-03-02",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05905887",
      "title": "Rivoceranib Plus Paclitaxel in Patients With Gastrointestinal Stromal Tumor",
      "status": "RECRUITING",
      "last_update": "2026-04-07",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06326346",
      "title": "GIST Oral Paclitaxel(Liporaxel)",
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      "last_update": "2026-04-07",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07096609",
      "title": "Lenvatinib After Progression on Imatinib, Sunitinib, and Regorafenib for GIST Patients",
      "status": "RECRUITING",
      "last_update": "2026-04-03",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07218926",
      "title": "A Study of IDRX-42 (GSK6042981) Versus (vs) Sunitinib in Participants With Gastrointestinal Stromal Tumors After Imatinib Therapy",
      "status": "RECRUITING",
      "last_update": "2026-09-08",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07689201",
      "title": "A Study of Velzatinib in Participants With Metastatic and/or Unresectable GIST After Imatinib, Sunitinib, Regorafenib, and Pimitespib",
      "status": "RECRUITING",
      "last_update": "2026-09-09",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00075218",
      "title": "A Study To Assess The Safety And Efficacy Of SU11248 In Patients With Gastrointestinal Stromal Tumor(GIST)",
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      "last_update": "2009-09-28",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00137449",
      "title": "Study Of SU011248 Administered On A Continuous Daily Dosing Schedule In Patients With Gastrointestinal Stromal Tumor",
      "status": "COMPLETED",
      "last_update": "2009-09-15",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00265798",
      "title": "Sorafenib in Treating Patients With Malignant Gastrointestinal Stromal Tumor That Progressed During or After Previous Treatment With Imatinib Mesylate and Sunitinib Malate",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-09-09",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00372567",
      "title": "Safety And Effectiveness Of Daily Dosing With Sunitinib Or Imatinib In Patients With Gastrointestinal Stromal Tumors",
      "status": "TERMINATED",
      "last_update": "2011-03-17",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00400569",
      "title": "Phase II Study of Sunitinib Malate for Metastatic and/or Surgically Unresectable Soft Tissue Sarcoma",
      "status": "COMPLETED",
      "last_update": "2012-08-28",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00428220",
      "title": "A Continuation Study Using Sunitinib Malate For Patients Leaving Treatment On A Previous Sunitinib Study.",
      "status": "COMPLETED",
      "last_update": "2019-06-27",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00457743",
      "title": "A Phase I/II Study of Sunitinib Malate (SU011248) In Patients With Gastrointestinal Stromal Tumor (GIST)",
      "status": "COMPLETED",
      "last_update": "2009-11-13",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00471328",
      "title": "Efficacy and Safety of Nilotinib (AMN107) Compared With Current Treatment Options in Patients With GIST Who Have Failed Both Imatinib and Sunitinib",
      "status": "COMPLETED",
      "last_update": "2012-06-12",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00570635",
      "title": "A Phase 2 Study of XL820 in Adults With Advanced GIST Resistant to Imatinib and/or Sunitinib",
      "status": "COMPLETED",
      "last_update": "2013-06-07",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00573404",
      "title": "Imatinib Mesylate and Sunitinib in Treating Patients With Gastrointestinal Stromal Tumors",
      "status": "TERMINATED",
      "last_update": "2011-11-16",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00618319",
      "title": "An Open-Label, 18FDG-PET Pharmacodynamic Assessment of the Effect of BIIB021 in Subjects With Gastrointestinal Stromal Tumors (GIST)",
      "status": "COMPLETED",
      "last_update": "2015-10-02",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00688766",
      "title": "Study Evaluating IPI-504 in Patients With Gastrointestinal Stromal Tumors (GIST) Following Failure of at Least Imatinib and Sunitinib",
      "status": "TERMINATED",
      "last_update": "2012-12-11",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00718562",
      "title": "Efficacy and Safety of AMN107 in Patients With GastroIntestinal Stromal Tumors (GIST) Who Have Failed Both Imatinib and Sunitinib",
      "status": "COMPLETED",
      "last_update": "2017-02-23",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00782834",
      "title": "Nilotinib in Advanced Gastrointestinal Stromal Tumors (GIST)",
      "status": "TERMINATED",
      "last_update": "2013-04-22",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00793871",
      "title": "Safety And Efficacy Study Of Sunitinib Malate In Chinese Patients With Imatinib Resistant Or Intolerant Malignant Gastrointestinal Stromal Tumor",
      "status": "COMPLETED",
      "last_update": "2015-11-20",
      "phase": "PHASE4",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01039519",
      "title": "A Study Evaluating STA-9090 in Patients With Metastatic and/or Unresectable Gastrointestinal Stromal Tumor (GIST)",
      "status": "COMPLETED",
      "last_update": "2016-03-10",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01054911",
      "title": "Evaluation of Patients With Bulky GIST Using Sunitinib",
      "status": "TERMINATED",
      "last_update": "2016-09-22",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01068769",
      "title": "Regorafenib in Patients With Metastatic and/or Unresectable Gastrointestinal Stromal Tumor",
      "status": "COMPLETED",
      "last_update": "2020-08-24",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01091207",
      "title": "Sorafenib for Imatinib/Sunitinib-failed GIST",
      "status": "COMPLETED",
      "last_update": "2012-01-20",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01151852",
      "title": "Rechallenge of Imatinib in GIST Having no Effective Treatment: RIGHT",
      "status": "COMPLETED",
      "last_update": "2020-01-14",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01271712",
      "title": "Study of Regorafenib as a 3rd-line or Beyond Treatment for Gastrointestinal Stromal Tumors (GIST)",
      "status": "COMPLETED",
      "last_update": "2021-01-29",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01289028",
      "title": "Efficacy of Nilotinib in Adult Patients With Gastrointestinal Stromal Tumors Resistant to Imatinib and Sunitinib.",
      "status": "COMPLETED",
      "last_update": "2017-01-02",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01323400",
      "title": "Efficacy of Pazopanib in Gastrointestinal Stromal Tumors (GIST)",
      "status": "COMPLETED",
      "last_update": "2016-02-25",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01381822",
      "title": "Dose-Escalation Study of TH-302 in Combination With Sunitinib to Treat Patients With Advanced Renal Cell Carcinoma,Gastrointestinal Stromal Tumors and Pancreatic Neuroendocrine Tumors",
      "status": "UNKNOWN",
      "last_update": "2014-04-21",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01389583",
      "title": "A Study of AUY922 for GIST(Gastrointestinal Stromal Tumor) Patients",
      "status": "UNKNOWN",
      "last_update": "2015-02-25",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01396148",
      "title": "A Study of Sunitinib In Young Patients With Advanced Gastrointestinal Stromal Tumor",
      "status": "COMPLETED",
      "last_update": "2019-03-27",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01402089",
      "title": "Cytochrom p450 3A4 and 1A2 Phenotyping for the Individualization of Treatment With Sunitinib or Erlotinib in Cancer Patients",
      "status": "COMPLETED",
      "last_update": "2016-02-02",
      "phase": "PHASE4",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01440959",
      "title": "Dovitinib for Imatinib/Sumitinib-failed Gastrointestinal Stromal Tumors (GIST): TKI258",
      "status": "COMPLETED",
      "last_update": "2020-01-18",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01468688",
      "title": "A Dose-finding Study of a Combination of Imatinib and BKM120 in the Treatment of 3rd Line GIST Patients",
      "status": "COMPLETED",
      "last_update": "2020-12-21",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01506336",
      "title": "Masitinib in Patients With Gastro-Intestinal Stromal Tumour Resistant to Imatinib",
      "status": "COMPLETED",
      "last_update": "2018-12-11",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01524848",
      "title": "Pazopanib in Advanced Gastrointestinal Stromal Tumors Refractory to Imatinib and Sunitinib",
      "status": "COMPLETED",
      "last_update": "2017-05-10",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01694277",
      "title": "Masitinib in Patients With Gastrointestinal Stromal Tumour After Progression With Imatinib",
      "status": "COMPLETED",
      "last_update": "2020-12-08",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01735968",
      "title": "A Dose-finding Study of a Combination of Imatinib and BYL719 in the Treatment of 3rd Line GIST Patients",
      "status": "COMPLETED",
      "last_update": "2020-12-21",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01743300",
      "title": "The Influence of Phenotype, Grapefruit Juice and Orange Juice on the Pharmacokinetics of Sunitinib in Cancer Patients",
      "status": "COMPLETED",
      "last_update": "2012-12-19",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01907607",
      "title": "Efficacy and Safety of PD-0332991 in Advanced Gastrointestinal Stromal Tumors Refractory to Imatinib and Sunitinib",
      "status": "COMPLETED",
      "last_update": "2025-08-24",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02164240",
      "title": "Phase Ib Study of SUnitinib Alternating With REgorafenib in Patients With Metastatic and/or Unresectable GIST",
      "status": "COMPLETED",
      "last_update": "2021-06-14",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02216578",
      "title": "Ph II CABOGIST in GIST",
      "status": "COMPLETED",
      "last_update": "2021-07-15",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02268435",
      "title": "Dovitinib in Combination With Imatinib in Patients With Gastrointestinal Stromal Tumors",
      "status": "WITHDRAWN",
      "last_update": "2015-08-04",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02342600",
      "title": "SARC029: Trametinib and Pazopanib in Patients With GIST (Gastrointestinal Stromal Tumor)",
      "status": "WITHDRAWN",
      "last_update": "2017-10-12",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02401815",
      "title": "CGT9486 (Formerly Known as PLX9486) as a Single Agent and in Combination With PLX3397 (Pexidartinib) or Sunitinib in Participants With Advanced Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2025-02-14",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02607332",
      "title": "Paclitaxel in Patients With Metastatic or Advanced Gastrointestinal Stromal Tumors (GIST) After Failure to Imatinib and Sunitinib",
      "status": "COMPLETED",
      "last_update": "2020-01-07",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02889328",
      "title": "Phase II Study of Regorafenib Continuous Dosing of Regorafenib in Patients With GISTs",
      "status": "COMPLETED",
      "last_update": "2020-01-09",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03171389",
      "title": "POETIG Trial - POnatinib After rEsisTance to Imatinib in GIST",
      "status": "UNKNOWN",
      "last_update": "2017-05-31",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03609424",
      "title": "PDR001 Plus Imatinib for Metastatic or Unresectable GIST",
      "status": "COMPLETED",
      "last_update": "2023-01-03",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03673501",
      "title": "A Study of Ripretinib vs Sunitinib in Advanced GIST Patients After Treatment With Imatinib",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-02-05",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03862768",
      "title": "Role of Surgery in Patients With Focally Progressive Gastrointestinal Stromal Tumors (GISTs) After Imatinib Treatment",
      "status": "UNKNOWN",
      "last_update": "2019-03-05",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03944304",
      "title": "Paclitaxel in Patients With GIST With Low P-glycoprotein Expression After Failure of at Least Imatinib and Sunitinib, and Regorafenib.",
      "status": "COMPLETED",
      "last_update": "2026-04-03",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04006769",
      "title": "Entacapone Combination With Imatinib for Treatment of GIST",
      "status": "COMPLETED",
      "last_update": "2023-10-18",
      "phase": "EARLY_PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04193553",
      "title": "Multicentre Placebo-controlled Double-blinded Phase II Study of Lenvatinib Efficacy in Patients With Locally Advanced or Metastatic GIST (Gastrointestinal Stromal Tumor) After Imatinib/Sunitinib Failure",
      "status": "COMPLETED",
      "last_update": "2024-06-18",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04409223",
      "title": "Efficacy and Safety of Famitinib Versus Sunitinib in the Treatment of Advanced Gastrointestinal Stromal Tumour Patients After Failure of Imatinib",
      "status": "TERMINATED",
      "last_update": "2024-02-09",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04633122",
      "title": "A Study to Assess DCC-2618 and Sunitinib in Patients With Advanced GIST After Treatment With Imatinib",
      "status": "COMPLETED",
      "last_update": "2026-04-03",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05160168",
      "title": "A Study of THE-630 in Patients With Advanced Gastrointestinal Stromal Tumors (GIST)",
      "status": "TERMINATED",
      "last_update": "2024-06-05",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05245968",
      "title": "A Study of Pimitespib in Combination With Imatinib in Patients With GIST (CHAPTER-GIST-101)",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-01-20",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05489237",
      "title": "First-in-human Study of IDRX-42 in Participants With Metastatic and/or Unresectable Gastrointestinal Stromal Tumors",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-07-02",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05734105",
      "title": "A Study of Ripretinib vs Sunitinib in Patients With Advanced GIST With Specific KIT Exon Mutations Who Were Previously Treated With Imatinib",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-12-17",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05800106",
      "title": "A Bioequivalence Study of Sunitinib Malate Capsules.",
      "status": "COMPLETED",
      "last_update": "2023-04-10",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06208748",
      "title": "SARC044: A Phase II Trial of Bezuclastinib in Combination With Sunitinib in Patients With GIST",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-10-31",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     }
    ]
   },
   "SUNITINIB MALATE": {
    "n": 65,
    "n_observational": 11,
    "n_active": 14,
    "n_withdrawn": 2,
    "trials": [
     {
      "nct": "NCT05208047",
      "title": "(Peak) A Phase 3 Randomized Trial of CGT9486+Sunitinib vs. Sunitinib in Subjects With Gastrointestinal Stromal Tumors",
      "status": "RECRUITING",
      "last_update": "2026-06-16",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05366816",
      "title": "ctDNA-Guided Sunitinib And Regorafenib Therapy for GIST",
      "status": "RECRUITING",
      "last_update": "2025-09-09",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05751733",
      "title": "Apatinib Mesylate Versus Standard Second-line TKI in the Treatment of Advanced GIST",
      "status": "RECRUITING",
      "last_update": "2023-03-02",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05905887",
      "title": "Rivoceranib Plus Paclitaxel in Patients With Gastrointestinal Stromal Tumor",
      "status": "RECRUITING",
      "last_update": "2026-04-07",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06326346",
      "title": "GIST Oral Paclitaxel(Liporaxel)",
      "status": "RECRUITING",
      "last_update": "2026-04-07",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07096609",
      "title": "Lenvatinib After Progression on Imatinib, Sunitinib, and Regorafenib for GIST Patients",
      "status": "RECRUITING",
      "last_update": "2026-04-03",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07218926",
      "title": "A Study of IDRX-42 (GSK6042981) Versus (vs) Sunitinib in Participants With Gastrointestinal Stromal Tumors After Imatinib Therapy",
      "status": "RECRUITING",
      "last_update": "2026-09-08",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07689201",
      "title": "A Study of Velzatinib in Participants With Metastatic and/or Unresectable GIST After Imatinib, Sunitinib, Regorafenib, and Pimitespib",
      "status": "RECRUITING",
      "last_update": "2026-09-09",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00075218",
      "title": "A Study To Assess The Safety And Efficacy Of SU11248 In Patients With Gastrointestinal Stromal Tumor(GIST)",
      "status": "COMPLETED",
      "last_update": "2009-09-28",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00137449",
      "title": "Study Of SU011248 Administered On A Continuous Daily Dosing Schedule In Patients With Gastrointestinal Stromal Tumor",
      "status": "COMPLETED",
      "last_update": "2009-09-15",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00265798",
      "title": "Sorafenib in Treating Patients With Malignant Gastrointestinal Stromal Tumor That Progressed During or After Previous Treatment With Imatinib Mesylate and Sunitinib Malate",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-09-09",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00372567",
      "title": "Safety And Effectiveness Of Daily Dosing With Sunitinib Or Imatinib In Patients With Gastrointestinal Stromal Tumors",
      "status": "TERMINATED",
      "last_update": "2011-03-17",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00400569",
      "title": "Phase II Study of Sunitinib Malate for Metastatic and/or Surgically Unresectable Soft Tissue Sarcoma",
      "status": "COMPLETED",
      "last_update": "2012-08-28",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00428220",
      "title": "A Continuation Study Using Sunitinib Malate For Patients Leaving Treatment On A Previous Sunitinib Study.",
      "status": "COMPLETED",
      "last_update": "2019-06-27",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00457743",
      "title": "A Phase I/II Study of Sunitinib Malate (SU011248) In Patients With Gastrointestinal Stromal Tumor (GIST)",
      "status": "COMPLETED",
      "last_update": "2009-11-13",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00471328",
      "title": "Efficacy and Safety of Nilotinib (AMN107) Compared With Current Treatment Options in Patients With GIST Who Have Failed Both Imatinib and Sunitinib",
      "status": "COMPLETED",
      "last_update": "2012-06-12",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00570635",
      "title": "A Phase 2 Study of XL820 in Adults With Advanced GIST Resistant to Imatinib and/or Sunitinib",
      "status": "COMPLETED",
      "last_update": "2013-06-07",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00573404",
      "title": "Imatinib Mesylate and Sunitinib in Treating Patients With Gastrointestinal Stromal Tumors",
      "status": "TERMINATED",
      "last_update": "2011-11-16",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00618319",
      "title": "An Open-Label, 18FDG-PET Pharmacodynamic Assessment of the Effect of BIIB021 in Subjects With Gastrointestinal Stromal Tumors (GIST)",
      "status": "COMPLETED",
      "last_update": "2015-10-02",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00688766",
      "title": "Study Evaluating IPI-504 in Patients With Gastrointestinal Stromal Tumors (GIST) Following Failure of at Least Imatinib and Sunitinib",
      "status": "TERMINATED",
      "last_update": "2012-12-11",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00718562",
      "title": "Efficacy and Safety of AMN107 in Patients With GastroIntestinal Stromal Tumors (GIST) Who Have Failed Both Imatinib and Sunitinib",
      "status": "COMPLETED",
      "last_update": "2017-02-23",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00782834",
      "title": "Nilotinib in Advanced Gastrointestinal Stromal Tumors (GIST)",
      "status": "TERMINATED",
      "last_update": "2013-04-22",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00793871",
      "title": "Safety And Efficacy Study Of Sunitinib Malate In Chinese Patients With Imatinib Resistant Or Intolerant Malignant Gastrointestinal Stromal Tumor",
      "status": "COMPLETED",
      "last_update": "2015-11-20",
      "phase": "PHASE4",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01039519",
      "title": "A Study Evaluating STA-9090 in Patients With Metastatic and/or Unresectable Gastrointestinal Stromal Tumor (GIST)",
      "status": "COMPLETED",
      "last_update": "2016-03-10",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01054911",
      "title": "Evaluation of Patients With Bulky GIST Using Sunitinib",
      "status": "TERMINATED",
      "last_update": "2016-09-22",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01068769",
      "title": "Regorafenib in Patients With Metastatic and/or Unresectable Gastrointestinal Stromal Tumor",
      "status": "COMPLETED",
      "last_update": "2020-08-24",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01091207",
      "title": "Sorafenib for Imatinib/Sunitinib-failed GIST",
      "status": "COMPLETED",
      "last_update": "2012-01-20",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01151852",
      "title": "Rechallenge of Imatinib in GIST Having no Effective Treatment: RIGHT",
      "status": "COMPLETED",
      "last_update": "2020-01-14",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01271712",
      "title": "Study of Regorafenib as a 3rd-line or Beyond Treatment for Gastrointestinal Stromal Tumors (GIST)",
      "status": "COMPLETED",
      "last_update": "2021-01-29",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01289028",
      "title": "Efficacy of Nilotinib in Adult Patients With Gastrointestinal Stromal Tumors Resistant to Imatinib and Sunitinib.",
      "status": "COMPLETED",
      "last_update": "2017-01-02",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01323400",
      "title": "Efficacy of Pazopanib in Gastrointestinal Stromal Tumors (GIST)",
      "status": "COMPLETED",
      "last_update": "2016-02-25",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01381822",
      "title": "Dose-Escalation Study of TH-302 in Combination With Sunitinib to Treat Patients With Advanced Renal Cell Carcinoma,Gastrointestinal Stromal Tumors and Pancreatic Neuroendocrine Tumors",
      "status": "UNKNOWN",
      "last_update": "2014-04-21",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01389583",
      "title": "A Study of AUY922 for GIST(Gastrointestinal Stromal Tumor) Patients",
      "status": "UNKNOWN",
      "last_update": "2015-02-25",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01396148",
      "title": "A Study of Sunitinib In Young Patients With Advanced Gastrointestinal Stromal Tumor",
      "status": "COMPLETED",
      "last_update": "2019-03-27",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01402089",
      "title": "Cytochrom p450 3A4 and 1A2 Phenotyping for the Individualization of Treatment With Sunitinib or Erlotinib in Cancer Patients",
      "status": "COMPLETED",
      "last_update": "2016-02-02",
      "phase": "PHASE4",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01440959",
      "title": "Dovitinib for Imatinib/Sumitinib-failed Gastrointestinal Stromal Tumors (GIST): TKI258",
      "status": "COMPLETED",
      "last_update": "2020-01-18",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01468688",
      "title": "A Dose-finding Study of a Combination of Imatinib and BKM120 in the Treatment of 3rd Line GIST Patients",
      "status": "COMPLETED",
      "last_update": "2020-12-21",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01506336",
      "title": "Masitinib in Patients With Gastro-Intestinal Stromal Tumour Resistant to Imatinib",
      "status": "COMPLETED",
      "last_update": "2018-12-11",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01524848",
      "title": "Pazopanib in Advanced Gastrointestinal Stromal Tumors Refractory to Imatinib and Sunitinib",
      "status": "COMPLETED",
      "last_update": "2017-05-10",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01694277",
      "title": "Masitinib in Patients With Gastrointestinal Stromal Tumour After Progression With Imatinib",
      "status": "COMPLETED",
      "last_update": "2020-12-08",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01735968",
      "title": "A Dose-finding Study of a Combination of Imatinib and BYL719 in the Treatment of 3rd Line GIST Patients",
      "status": "COMPLETED",
      "last_update": "2020-12-21",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01743300",
      "title": "The Influence of Phenotype, Grapefruit Juice and Orange Juice on the Pharmacokinetics of Sunitinib in Cancer Patients",
      "status": "COMPLETED",
      "last_update": "2012-12-19",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01907607",
      "title": "Efficacy and Safety of PD-0332991 in Advanced Gastrointestinal Stromal Tumors Refractory to Imatinib and Sunitinib",
      "status": "COMPLETED",
      "last_update": "2025-08-24",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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      "nct": "NCT02164240",
      "title": "Phase Ib Study of SUnitinib Alternating With REgorafenib in Patients With Metastatic and/or Unresectable GIST",
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      "title": "Ph II CABOGIST in GIST",
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      "nct": "NCT02268435",
      "title": "Dovitinib in Combination With Imatinib in Patients With Gastrointestinal Stromal Tumors",
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     {
      "nct": "NCT02342600",
      "title": "SARC029: Trametinib and Pazopanib in Patients With GIST (Gastrointestinal Stromal Tumor)",
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     {
      "nct": "NCT02401815",
      "title": "CGT9486 (Formerly Known as PLX9486) as a Single Agent and in Combination With PLX3397 (Pexidartinib) or Sunitinib in Participants With Advanced Solid Tumors",
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     },
     {
      "nct": "NCT02607332",
      "title": "Paclitaxel in Patients With Metastatic or Advanced Gastrointestinal Stromal Tumors (GIST) After Failure to Imatinib and Sunitinib",
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      "last_update": "2020-01-07",
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     {
      "nct": "NCT02889328",
      "title": "Phase II Study of Regorafenib Continuous Dosing of Regorafenib in Patients With GISTs",
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     {
      "nct": "NCT03171389",
      "title": "POETIG Trial - POnatinib After rEsisTance to Imatinib in GIST",
      "status": "UNKNOWN",
      "last_update": "2017-05-31",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT03609424",
      "title": "PDR001 Plus Imatinib for Metastatic or Unresectable GIST",
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      "last_update": "2023-01-03",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT03673501",
      "title": "A Study of Ripretinib vs Sunitinib in Advanced GIST Patients After Treatment With Imatinib",
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      "last_update": "2026-02-05",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT03862768",
      "title": "Role of Surgery in Patients With Focally Progressive Gastrointestinal Stromal Tumors (GISTs) After Imatinib Treatment",
      "status": "UNKNOWN",
      "last_update": "2019-03-05",
      "phase": "NA",
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     {
      "nct": "NCT03944304",
      "title": "Paclitaxel in Patients With GIST With Low P-glycoprotein Expression After Failure of at Least Imatinib and Sunitinib, and Regorafenib.",
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      "last_update": "2026-04-03",
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     {
      "nct": "NCT04006769",
      "title": "Entacapone Combination With Imatinib for Treatment of GIST",
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      "last_update": "2023-10-18",
      "phase": "EARLY_PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT04193553",
      "title": "Multicentre Placebo-controlled Double-blinded Phase II Study of Lenvatinib Efficacy in Patients With Locally Advanced or Metastatic GIST (Gastrointestinal Stromal Tumor) After Imatinib/Sunitinib Failure",
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     {
      "nct": "NCT04409223",
      "title": "Efficacy and Safety of Famitinib Versus Sunitinib in the Treatment of Advanced Gastrointestinal Stromal Tumour Patients After Failure of Imatinib",
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     {
      "nct": "NCT04633122",
      "title": "A Study to Assess DCC-2618 and Sunitinib in Patients With Advanced GIST After Treatment With Imatinib",
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      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT05160168",
      "title": "A Study of THE-630 in Patients With Advanced Gastrointestinal Stromal Tumors (GIST)",
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     {
      "nct": "NCT05245968",
      "title": "A Study of Pimitespib in Combination With Imatinib in Patients With GIST (CHAPTER-GIST-101)",
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     {
      "nct": "NCT05489237",
      "title": "First-in-human Study of IDRX-42 in Participants With Metastatic and/or Unresectable Gastrointestinal Stromal Tumors",
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      "last_update": "2026-07-02",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05734105",
      "title": "A Study of Ripretinib vs Sunitinib in Patients With Advanced GIST With Specific KIT Exon Mutations Who Were Previously Treated With Imatinib",
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      "last_update": "2025-12-17",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05800106",
      "title": "A Bioequivalence Study of Sunitinib Malate Capsules.",
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      "last_update": "2023-04-10",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06208748",
      "title": "SARC044: A Phase II Trial of Bezuclastinib in Combination With Sunitinib in Patients With GIST",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-10-31",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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    ]
   },
   "VATALANIB": {
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    "trials": [
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      "nct": "NCT00117299",
      "title": "PTK787/ZK222584 in the Treatment of Metastatic Gastrointestinal Stromal Tumors Resistant to Imatinib",
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     {
      "nct": "NCT00570635",
      "title": "A Phase 2 Study of XL820 in Adults With Advanced GIST Resistant to Imatinib and/or Sunitinib",
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  }
 }
}