{
 "disease": "head-and-neck-cancer",
 "label": "Head and neck cancer",
 "url": "https://usebiotransfer.org/disease/head-and-neck-cancer/",
 "built": "2026-09-12",
 "facts_hash": {
  "answers": "1d45b5ba9b00",
  "targets": "f7ba811bb4f3"
 },
 "sources": {
  "targets": "Open Targets Platform GraphQL API v4",
  "trials": "ClinicalTrials.gov API v2"
 },
 "retrieved": {
  "targets": "2026-09-12",
  "trials": "2026-09-12"
 },
 "query": {
  "endpoint": "https://clinicaltrials.gov/api/v2/studies",
  "shape": "query.cond=<disease>&query.intr=<term>&pageSize=200",
  "active_statuses": [
   "ACTIVE_NOT_RECRUITING",
   "ENROLLING_BY_INVITATION",
   "NOT_YET_RECRUITING",
   "RECRUITING"
  ],
  "dedup": "by NCT id across synonyms",
  "study_types": "interventional counted in headline; observational reported separately",
  "known_floor": "trials naming an antigen only by product code are not retrieved by an intervention-name search"
 },
 "targets": [
  {
   "symbol": "TP53",
   "ensembl": "ENSG00000141510",
   "n_drug_entries": 9,
   "n_distinct_drugs": 8,
   "drugs": {
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    "CENERSEN": "PHASE_2",
    "CONTUSUGENE LADENOVEC": "PHASE_3",
    "EPRENETAPOPT": "PHASE_3",
    "IDASANUTLIN": "PHASE_3",
    "NAVTEMADLIN": "PHASE_3",
    "SIREMADLIN": "PHASE_2",
    "TEPRASIRAN": "PHASE_3"
   },
   "approved": [],
   "n_approved": 0,
   "approved_for": {},
   "tractability": [
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     "modality": "SM",
     "bucket": "Advanced Clinical"
    },
    {
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     "bucket": "Structure with Ligand"
    },
    {
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     "bucket": "High-Quality Ligand"
    },
    {
     "modality": "SM",
     "bucket": "Med-Quality Pocket"
    },
    {
     "modality": "SM",
     "bucket": "Druggable Family"
    },
    {
     "modality": "PR",
     "bucket": "UniProt Ubiquitination"
    },
    {
     "modality": "PR",
     "bucket": "Database Ubiquitination"
    },
    {
     "modality": "PR",
     "bucket": "Small Molecule Binder"
    },
    {
     "modality": "OC",
     "bucket": "Advanced Clinical"
    }
   ]
  },
  {
   "symbol": "CDKN2A",
   "ensembl": "ENSG00000147889",
   "n_drug_entries": 0,
   "n_distinct_drugs": 0,
   "drugs": {},
   "approved": [],
   "n_approved": 0,
   "approved_for": {},
   "tractability": []
  },
  {
   "symbol": "PIK3CA",
   "ensembl": "ENSG00000121879",
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   "n_distinct_drugs": 31,
   "drugs": {
    "ALPELISIB": "APPROVAL",
    "APITOLISIB": "PHASE_2",
    "AZD-6482": "UNKNOWN",
    "BAY-1082439": "PHASE_1",
    "BGT-226": "PHASE_1_2",
    "BUPARLISIB": "PHASE_3",
    "COPANLISIB": "APPROVAL",
    "DACTOLISIB": "PHASE_3",
    "DS-7423": "PHASE_1",
    "FIMEPINOSTAT": "PHASE_2",
    "GEDATOLISIB": "PHASE_3",
    "GSK-1059615": "PHASE_1",
    "INAVOLISIB": "APPROVAL",
    "IZORLISIB": "PHASE_1_2",
    "OMIPALISIB": "PHASE_1",
    "PANULISIB": "PHASE_1",
    "PAXALISIB": "PHASE_2_3",
    "PF-04691502": "PHASE_2",
    "PICTILISIB": "PHASE_2",
    "PILARALISIB": "PHASE_2",
    "PKI-179": "PHASE_1",
    "RECILISIB": "PHASE_1",
    "SAMOTOLISIB": "PHASE_2",
    "SERABELISIB": "PHASE_2",
    "SF-1126": "PHASE_2",
    "SONOLISIB": "PHASE_2",
    "TASELISIB": "PHASE_3",
    "VOXTALISIB": "PHASE_2",
    "VS-5584": "PHASE_1",
    "WX-037": "PHASE_1",
    "ZSTK-474": "PHASE_1"
   },
   "approved": [
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    "COPANLISIB",
    "INAVOLISIB"
   ],
   "n_approved": 3,
   "approved_for": {
    "ALPELISIB": [
     "breast cancer",
     "breast neoplasm",
     "breast carcinoma"
    ],
    "COPANLISIB": [
     "follicular lymphoma",
     "non-Hodgkin lymphoma",
     "neoplasm of mature B-cells"
    ],
    "INAVOLISIB": [
     "breast neoplasm"
    ]
   },
   "tractability": [
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     "modality": "SM",
     "bucket": "Approved Drug"
    },
    {
     "modality": "SM",
     "bucket": "Structure with Ligand"
    },
    {
     "modality": "SM",
     "bucket": "High-Quality Ligand"
    },
    {
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     "bucket": "High-Quality Pocket"
    },
    {
     "modality": "SM",
     "bucket": "Druggable Family"
    },
    {
     "modality": "AB",
     "bucket": "GO CC med conf"
    },
    {
     "modality": "PR",
     "bucket": "Literature"
    },
    {
     "modality": "PR",
     "bucket": "Database Ubiquitination"
    },
    {
     "modality": "PR",
     "bucket": "Half-life Data"
    },
    {
     "modality": "PR",
     "bucket": "Small Molecule Binder"
    }
   ]
  },
  {
   "symbol": "EGFR",
   "ensembl": "ENSG00000146648",
   "n_drug_entries": 82,
   "n_distinct_drugs": 74,
   "drugs": {
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    "AC-480": "PHASE_2",
    "AEE-788": "PHASE_1_2",
    "AFATINIB": "APPROVAL",
    "AFATINIB DIMALEATE": "APPROVAL",
    "ALLITINIB": "PHASE_1",
    "AMIVANTAMAB": "APPROVAL",
    "AUMOLERTINIB": "APPROVAL",
    "AV-412": "PHASE_1",
    "AZD-3759": "PHASE_2_3",
    "AZD-4769": "PHASE_1",
    "BAFISONTAMAB": "PHASE_2",
    "BMS-690514": "PHASE_2",
    "BRIGATINIB": "APPROVAL",
    "CANERTINIB": "PHASE_2",
    "CEP-32496": "PHASE_1_2",
    "CETUXIMAB": "APPROVAL",
    "CETUXIMAB SAROTALOCAN": "APPROVAL",
    "CLN-081": "PHASE_3",
    "CUDC-101": "PHASE_1",
    "DACOMITINIB": "APPROVAL",
    "DEPATUXIZUMAB": "PHASE_2",
    "DEPATUXIZUMAB MAFODOTIN": "PHASE_3",
    "DULIGOTUZUMAB": "PHASE_2",
    "EPITINIB": "PHASE_1",
    "ERLOTINIB": "APPROVAL",
    "FALNIDAMOL": "PHASE_1",
    "FIRMONERTINIB": "PHASE_3",
    "FUTUXIMAB": "PHASE_3",
    "GC1118": "PHASE_2",
    "GEFITINIB": "APPROVAL",
    "ICOTINIB": "APPROVAL",
    "IMGATUZUMAB": "PHASE_2",
    "JNJ-26483327": "PHASE_1",
    "KBP5209": "PHASE_1",
    "LAPATINIB": "APPROVAL",
    "LAPATINIB DITOSYLATE": "APPROVAL",
    "LAZERTINIB": "APPROVAL",
    "LOSATUXIZUMAB VEDOTIN": "PHASE_1",
    "MAB-425": "UNKNOWN",
    "MATUZUMAB": "PHASE_2",
    "MAVELERTINIB": "PHASE_1_2",
    "MDX-447": "PHASE_1",
    "MOBOCERTINIB": "APPROVAL",
    "MODOTUXIMAB": "PHASE_2",
    "NAQUOTINIB": "PHASE_3",
    "NAZARTINIB": "PHASE_3",
    "NECITUMUMAB": "APPROVAL",
    "NERATINIB": "APPROVAL",
    "NIMOTUZUMAB": "APPROVAL",
    "OLMUTINIB": "APPROVAL",
    "OSIMERTINIB": "APPROVAL",
    "PANITUMUMAB": "APPROVAL",
    "PELITINIB": "PHASE_2",
    "PF-06459988": "PHASE_2",
    "PIMURUTAMAB": "PHASE_2_3",
    "PKI-166": "PHASE_2",
    "POZIOTINIB": "PHASE_3",
    "PYROTINIB": "PHASE_3",
    "RINDOPEPIMUT": "PHASE_3",
    "ROCILETINIB": "APPROVAL",
    "RUSERONTINIB": "PHASE_3",
    "S-222611": "PHASE_1",
    "SAPITINIB": "PHASE_2",
    "SIMOTINIB": "PHASE_1",
    "TAK-285": "PHASE_1",
    "TARLOXOTINIB": "PHASE_2",
    "TESEVATINIB": "PHASE_3",
    "THELIATINIB": "PHASE_1",
    "TOMUZOTUXIMAB": "PHASE_2",
    "TUXOBERTINIB": "PHASE_1_2",
    "VANDETANIB": "APPROVAL",
    "VARLITINIB": "PHASE_2_3",
    "ZALUTUMUMAB": "PHASE_3"
   },
   "approved": [
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    "AFATINIB DIMALEATE",
    "AMIVANTAMAB",
    "AUMOLERTINIB",
    "BRIGATINIB",
    "CETUXIMAB",
    "CETUXIMAB SAROTALOCAN",
    "DACOMITINIB",
    "ERLOTINIB",
    "GEFITINIB",
    "ICOTINIB",
    "LAPATINIB",
    "LAPATINIB DITOSYLATE",
    "LAZERTINIB",
    "MOBOCERTINIB",
    "NECITUMUMAB",
    "NERATINIB",
    "NIMOTUZUMAB",
    "OLMUTINIB",
    "OSIMERTINIB",
    "PANITUMUMAB",
    "ROCILETINIB",
    "VANDETANIB"
   ],
   "n_approved": 23,
   "approved_for": {
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     "non-small cell lung carcinoma"
    ],
    "AFATINIB DIMALEATE": [
     "non-small cell lung carcinoma"
    ],
    "AMIVANTAMAB": [
     "non-small cell lung carcinoma"
    ],
    "AUMOLERTINIB": [
     "non-small cell lung carcinoma"
    ],
    "BRIGATINIB": [
     "non-small cell lung carcinoma",
     "anaplastic large cell lymphoma"
    ],
    "CETUXIMAB": [
     "malignant tumor of neck",
     "squamous cell carcinoma",
     "colorectal adenocarcinoma",
     "colorectal carcinoma",
     "colorectal cancer",
     "head and neck neoplasm",
     "colorectal neoplasm"
    ],
    "CETUXIMAB SAROTALOCAN": [
     "head and neck cancer"
    ],
    "DACOMITINIB": [
     "non-small cell lung carcinoma"
    ],
    "ERLOTINIB": [
     "non-small cell lung carcinoma",
     "pancreatic neoplasm"
    ],
    "GEFITINIB": [
     "non-small cell lung carcinoma",
     "head and neck squamous cell carcinoma"
    ],
    "ICOTINIB": [],
    "LAPATINIB": [
     "breast cancer"
    ],
    "LAPATINIB DITOSYLATE": [
     "breast cancer",
     "breast neoplasm",
     "breast carcinoma"
    ],
    "LAZERTINIB": [
     "non-small cell lung carcinoma"
    ],
    "MOBOCERTINIB": [
     "non-small cell lung carcinoma"
    ],
    "NECITUMUMAB": [
     "non-small cell lung carcinoma",
     "colorectal cancer",
     "non-small cell squamous lung carcinoma"
    ],
    "NERATINIB": [
     "breast cancer",
     "breast neoplasm",
     "breast carcinoma"
    ],
    "NIMOTUZUMAB": [
     "head and neck cancer"
    ],
    "OLMUTINIB": [],
    "OSIMERTINIB": [
     "non-small cell lung carcinoma"
    ],
    "PANITUMUMAB": [
     "colorectal cancer",
     "colorectal adenocarcinoma",
     "colorectal neoplasm"
    ],
    "ROCILETINIB": [],
    "VANDETANIB": [
     "thyroid gland carcinoma",
     "medullary thyroid gland carcinoma",
     "thyroid tumor"
    ]
   },
   "tractability": [
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     "modality": "SM",
     "bucket": "Approved Drug"
    },
    {
     "modality": "SM",
     "bucket": "Structure with Ligand"
    },
    {
     "modality": "SM",
     "bucket": "High-Quality Ligand"
    },
    {
     "modality": "SM",
     "bucket": "High-Quality Pocket"
    },
    {
     "modality": "SM",
     "bucket": "Druggable Family"
    },
    {
     "modality": "AB",
     "bucket": "Approved Drug"
    },
    {
     "modality": "AB",
     "bucket": "UniProt loc high conf"
    },
    {
     "modality": "AB",
     "bucket": "GO CC high conf"
    },
    {
     "modality": "AB",
     "bucket": "UniProt loc med conf"
    },
    {
     "modality": "AB",
     "bucket": "UniProt SigP or TMHMM"
    },
    {
     "modality": "AB",
     "bucket": "Human Protein Atlas loc"
    },
    {
     "modality": "PR",
     "bucket": "Literature"
    },
    {
     "modality": "PR",
     "bucket": "UniProt Ubiquitination"
    },
    {
     "modality": "PR",
     "bucket": "Database Ubiquitination"
    },
    {
     "modality": "PR",
     "bucket": "Half-life Data"
    },
    {
     "modality": "PR",
     "bucket": "Small Molecule Binder"
    },
    {
     "modality": "OC",
     "bucket": "Advanced Clinical"
    }
   ]
  },
  {
   "symbol": "CD274",
   "ensembl": "ENSG00000120217",
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   "n_distinct_drugs": 13,
   "drugs": {
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    "ATEZOLIZUMAB": "APPROVAL",
    "AVELUMAB": "APPROVAL",
    "BINTRAFUSP ALFA": "PHASE_3",
    "COSIBELIMAB": "APPROVAL",
    "DANBURSTOTUG": "PHASE_2",
    "DURVALUMAB": "APPROVAL",
    "ENVAFOLIMAB": "PHASE_3",
    "ERFONRILIMAB": "PHASE_3",
    "INCB-086550": "PHASE_2",
    "PACMILIMAB": "PHASE_2",
    "SOCAZOLIMAB": "PHASE_3",
    "SUGEMALIMAB": "APPROVAL"
   },
   "approved": [
    "ATEZOLIZUMAB",
    "AVELUMAB",
    "COSIBELIMAB",
    "DURVALUMAB",
    "SUGEMALIMAB"
   ],
   "n_approved": 5,
   "approved_for": {
    "ATEZOLIZUMAB": [
     "urothelial carcinoma",
     "non-small cell lung carcinoma",
     "breast cancer",
     "small cell lung carcinoma",
     "breast neoplasm",
     "transitional cell carcinoma"
    ],
    "AVELUMAB": [
     "Merkel cell skin cancer",
     "urothelial carcinoma",
     "neuroendocrine neoplasm"
    ],
    "COSIBELIMAB": [
     "head and neck squamous cell carcinoma"
    ],
    "DURVALUMAB": [
     "non-small cell lung carcinoma",
     "small cell lung carcinoma",
     "urothelial carcinoma",
     "hepatocellular carcinoma"
    ],
    "SUGEMALIMAB": [
     "non-small cell lung carcinoma"
    ]
   },
   "tractability": [
    {
     "modality": "SM",
     "bucket": "Structure with Ligand"
    },
    {
     "modality": "SM",
     "bucket": "High-Quality Ligand"
    },
    {
     "modality": "SM",
     "bucket": "Med-Quality Pocket"
    },
    {
     "modality": "AB",
     "bucket": "Approved Drug"
    },
    {
     "modality": "AB",
     "bucket": "UniProt loc high conf"
    },
    {
     "modality": "AB",
     "bucket": "GO CC high conf"
    },
    {
     "modality": "AB",
     "bucket": "UniProt SigP or TMHMM"
    },
    {
     "modality": "PR",
     "bucket": "Literature"
    },
    {
     "modality": "PR",
     "bucket": "UniProt Ubiquitination"
    },
    {
     "modality": "PR",
     "bucket": "Small Molecule Binder"
    },
    {
     "modality": "OC",
     "bucket": "Advanced Clinical"
    }
   ]
  },
  {
   "symbol": "PDCD1",
   "ensembl": "ENSG00000188389",
   "n_drug_entries": 26,
   "n_distinct_drugs": 26,
   "drugs": {
    "APL-501": "PHASE_2",
    "BALSTILIMAB": "PHASE_3",
    "BUDIGALIMAB": "PHASE_2_3",
    "CADONILIMAB": "PHASE_3",
    "CAMRELIZUMAB": "PHASE_3",
    "CEMIPLIMAB": "APPROVAL",
    "CETRELIMAB": "PHASE_3",
    "CS-1003": "PHASE_3",
    "DOSTARLIMAB": "APPROVAL",
    "FINOTONLIMAB": "PHASE_3",
    "LOMVASTOMIG": "PHASE_2",
    "NIVOLUMAB": "APPROVAL",
    "PEMBROLIZUMAB": "APPROVAL",
    "PENPULIMAB": "PHASE_3",
    "PIDILIZUMAB": "PHASE_2",
    "PIMIVALIMAB": "PHASE_2",
    "PUCOTENLIMAB": "PHASE_3",
    "RETIFANLIMAB": "APPROVAL",
    "SASANLIMAB": "PHASE_3",
    "SERPLULIMAB": "APPROVAL",
    "SINTILIMAB": "APPROVAL",
    "SPARTALIZUMAB": "PHASE_3",
    "TEBOTELIMAB": "PHASE_2_3",
    "TISLELIZUMAB": "APPROVAL",
    "TORIPALIMAB": "APPROVAL",
    "ZIMBERELIMAB": "PHASE_3"
   },
   "approved": [
    "CEMIPLIMAB",
    "DOSTARLIMAB",
    "NIVOLUMAB",
    "PEMBROLIZUMAB",
    "RETIFANLIMAB",
    "SERPLULIMAB",
    "SINTILIMAB",
    "TISLELIZUMAB",
    "TORIPALIMAB"
   ],
   "n_approved": 9,
   "approved_for": {
    "CEMIPLIMAB": [
     "squamous cell carcinoma",
     "basal cell carcinoma",
     "cutaneous squamous cell carcinoma",
     "cervical cancer"
    ],
    "DOSTARLIMAB": [
     "endometrial cancer",
     "endometrial neoplasm"
    ],
    "NIVOLUMAB": [
     "head and neck cancer",
     "pleural mesothelioma",
     "gastric cancer",
     "melanoma",
     "non-small cell lung carcinoma",
     "renal cell carcinoma",
     "transitional cell carcinoma",
     "colorectal neoplasm",
     "Hodgkins lymphoma",
     "mesothelioma",
     "head and neck squamous cell carcinoma",
     "classic Hodgkin lymphoma",
     "metastatic melanoma"
    ],
    "PEMBROLIZUMAB": [
     "melanoma",
     "metastatic melanoma",
     "endometrium neoplasm",
     "head and neck squamous cell carcinoma",
     "transitional cell carcinoma",
     "renal cell carcinoma",
     "Hodgkins lymphoma",
     "non-small cell lung carcinoma"
    ],
    "RETIFANLIMAB": [
     "neuroendocrine carcinoma",
     "Merkel cell skin cancer",
     "squamous cell carcinoma"
    ],
    "SERPLULIMAB": [
     "esophageal squamous cell carcinoma",
     "non-small cell lung carcinoma",
     "small cell lung carcinoma"
    ],
    "SINTILIMAB": [
     "Hodgkins lymphoma"
    ],
    "TISLELIZUMAB": [
     "esophageal cancer",
     "Hodgkins lymphoma",
     "non-small cell lung carcinoma",
     "adenocarcinoma",
     "esophageal squamous cell carcinoma",
     "gastric neoplasm"
    ],
    "TORIPALIMAB": [
     "melanoma",
     "nasopharyngeal carcinoma",
     "urothelial carcinoma",
     "esophageal squamous cell carcinoma",
     "Niemann-Pick disease type B"
    ]
   },
   "tractability": [
    {
     "modality": "SM",
     "bucket": "Structure with Ligand"
    },
    {
     "modality": "SM",
     "bucket": "High-Quality Ligand"
    },
    {
     "modality": "AB",
     "bucket": "Approved Drug"
    },
    {
     "modality": "AB",
     "bucket": "UniProt loc high conf"
    },
    {
     "modality": "AB",
     "bucket": "GO CC high conf"
    },
    {
     "modality": "AB",
     "bucket": "UniProt SigP or TMHMM"
    },
    {
     "modality": "PR",
     "bucket": "Literature"
    },
    {
     "modality": "PR",
     "bucket": "UniProt Ubiquitination"
    },
    {
     "modality": "PR",
     "bucket": "Small Molecule Binder"
    },
    {
     "modality": "OC",
     "bucket": "Advanced Clinical"
    }
   ]
  },
  {
   "symbol": "NOTCH1",
   "ensembl": "ENSG00000148400",
   "n_drug_entries": 1,
   "n_distinct_drugs": 1,
   "drugs": {
    "BRONTICTUZUMAB": "PHASE_1"
   },
   "approved": [],
   "n_approved": 0,
   "approved_for": {},
   "tractability": [
    {
     "modality": "SM",
     "bucket": "Structure with Ligand"
    },
    {
     "modality": "SM",
     "bucket": "High-Quality Ligand"
    },
    {
     "modality": "SM",
     "bucket": "Med-Quality Pocket"
    },
    {
     "modality": "SM",
     "bucket": "Druggable Family"
    },
    {
     "modality": "AB",
     "bucket": "Advanced Clinical"
    },
    {
     "modality": "AB",
     "bucket": "GO CC high conf"
    },
    {
     "modality": "AB",
     "bucket": "UniProt loc med conf"
    },
    {
     "modality": "AB",
     "bucket": "UniProt SigP or TMHMM"
    },
    {
     "modality": "PR",
     "bucket": "UniProt Ubiquitination"
    },
    {
     "modality": "PR",
     "bucket": "Database Ubiquitination"
    },
    {
     "modality": "PR",
     "bucket": "Half-life Data"
    },
    {
     "modality": "PR",
     "bucket": "Small Molecule Binder"
    }
   ]
  },
  {
   "symbol": "FAT1",
   "ensembl": "ENSG00000083857",
   "n_drug_entries": 0,
   "n_distinct_drugs": 0,
   "drugs": {},
   "approved": [],
   "n_approved": 0,
   "approved_for": {},
   "tractability": [
    {
     "modality": "AB",
     "bucket": "UniProt loc high conf"
    },
    {
     "modality": "AB",
     "bucket": "GO CC high conf"
    },
    {
     "modality": "AB",
     "bucket": "UniProt SigP or TMHMM"
    },
    {
     "modality": "PR",
     "bucket": "Database Ubiquitination"
    },
    {
     "modality": "PR",
     "bucket": "Half-life Data"
    }
   ]
  },
  {
   "symbol": "CCND1",
   "ensembl": "ENSG00000110092",
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      "title": "Study of AU-007, A Monoclonal Antibody That Binds to IL-2 and Inhibits IL-2R\u03b1 Binding, in Patients With Unresectable Locally Advanced or Metastatic Cancer",
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      "title": "Metronomic Capecitabine With or Without PD-1 Antibody as Adjuvant Therapy in High-risk Nasopharyngeal Carcinoma",
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      "title": "ATATcH Alternating Treatment Plans for Advanced Cancer",
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      "title": "Open Label Phase 2 Basket Trial With Atezolizumab and Tiragolumab in Solid Tumors",
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      "nct": "NCT05784688",
      "title": "Study of TU2218 in Combination With KEYTRUDA\u00ae(Pembrolizumab) in Patients With Advanced Solid Tumors",
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      "title": "pBI-11 & TA-HPV (With Pembrolizumab as Treatment for Patients w/Advanced, PD-L1 CPS\u22651, hrHPV+ Oropharyngeal Cancer",
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      "title": "Study of RiMO-301 and Radiotherapy With PD-1 Inhibitor for the Treatment of Head-Neck Cancer",
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      "title": "A Study of MQ710 With and Without Pembrolizumab in People With Solid Tumor Cancer",
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      "title": "A Dose Escalation and Dose Expansion Study of Intratumoral ONM-501 Alone and in Combination With Cemiplimab in Patients With Advanced Solid Tumors and Lymphomas.",
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      "title": "A Study to Compare the Efficacy and Safety of LY01015 and Opdivo\u00ae Combined Respectively With Chemotherapy in Advanced or Metastatic Esophageal Squamous Cell Carcinoma",
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      "title": "Testing the Addition of BMS-986016 (Relatlimab) to the Usual Immunotherapy After Initial Treatment for Recurrent or Metastatic Nasopharyngeal Cancer",
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      "nct": "NCT06047379",
      "title": "Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis",
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      "title": "A Study Using Nivolumab, in Combination With Chemotherapy Drugs to Treat Nasopharyngeal Carcinoma (NPC)",
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      "nct": "NCT06084897",
      "title": "Radiotherapy in Patients With Metastatic Esophageal Cancer Responding to PD-1 Inhibitor Plus Chemotherapy",
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      "nct": "NCT06086457",
      "title": "PD-1 Inhibitor Plus Chemotherapy With or Without Radiotherapy in Patients With Metastatic Esophageal Cancer",
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      "nct": "NCT06102395",
      "title": "Evaluating the Efficacy and Safety of Pembrolizumab Plus Standard Chemotherapy in the Neoadjuvant Treatment of Local Advanced (LA) HNSCC",
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      "last_update": "2023-10-30",
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     {
      "nct": "NCT06122493",
      "title": "Optimization of Treatment Strategy for Unresectable cN3 Esophageal Squamous Cell Carcinoma",
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      "last_update": "2023-11-08",
      "phase": "PHASE2",
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     {
      "nct": "NCT06137378",
      "title": "European Larynx Organ Preservation Study (ELOS) [MK-3475-C44]",
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      "nct": "NCT06161545",
      "title": "Pembrolizumab + N-803 Alone or in Combination With PD-L1 t-haNK Cells for Resectable Head and Neck Squamous Cell Carcinoma",
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      "nct": "NCT06170710",
      "title": "Postoperative CCRT Followed by Immunotherapy in High-Risk LA HNSCC",
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      "last_update": "2023-12-14",
      "phase": "PHASE2",
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      "nct": "NCT06190782",
      "title": "Local Therapy for Oligometastatic ESCC Patients Treated With PD-1 Inhibitor",
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      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
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      "nct": "NCT06265285",
      "title": "Comparison of In-Home Versus In-Clinic Administration of Subcutaneous Nivolumab Through Cancer CARE (Connected Access and Remote Expertise) Beyond Walls (CCBW) Program",
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      "last_update": "2026-06-09",
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      "study_type": "INTERVENTIONAL"
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      "nct": "NCT06270706",
      "title": "A Phase 1 Study of PLN-101095 in Adults With Advanced or Metastatic Solid Tumors",
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     {
      "nct": "NCT06323239",
      "title": "SBRT and LDRT Combined With PD-1 Antibody and Chemotherapy in r/m Nasopharyngeal Carcinoma",
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      "last_update": "2026-05-11",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06383780",
      "title": "Tislelizumab in Combination With GP or TPC Regimen for the Treatment of Nasopharyngeal Carcinoma With Bone Metastasis.",
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     {
      "nct": "NCT06422403",
      "title": "A Value-Driven Study on Reducing Immune Checkpoint Inhibitor Dosing Frequency in Advanced Cancers",
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     {
      "nct": "NCT06445972",
      "title": "Substudy 06D: Combination Therapies in Second Line (2L) Gastroesophageal Adenocarcinoma (MK-3475-06D/Keymaker-U06)",
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      "phase": "PHASE1/PHASE2",
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     {
      "nct": "NCT06448026",
      "title": "Cemiplimab and Cetuximab Prior Salvage Surgery in Patients With Recurrent Oral Cavity and HPV-negative Oropharyngeal Squamous Cell Carcinoma",
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      "phase": "PHASE2",
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     {
      "nct": "NCT06457503",
      "title": "A Study of Toripalimab in Combination With Cisplatin and Gemcitabine in Participants With Recurrent Metastatic Nasopharyngeal Cancer",
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      "last_update": "2026-07-30",
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     {
      "nct": "NCT06469944",
      "title": "Substudy 06C: A Study of Investigational Agents With Pembrolizumab (MK-3475) and Chemotherapy in Participants With First-Line Locally Advanced Unresectable/Metastatic Gastroesophageal Adenocarcinoma (MK-3475-06C/KEYMAKER-U06)",
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     {
      "nct": "NCT06494995",
      "title": "AK104 and Low-dose Radiation in Recurrent/Metastatic HNSCC After Failure of First-line Systemic Therapy",
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      "phase": "PHASE2",
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     {
      "nct": "NCT06532799",
      "title": "TIL Therapy Combined With Pembrolizumab for Advanced or Metastatic Refractory Stomach and Esophageal Cancer",
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      "phase": "PHASE1/PHASE2",
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     {
      "nct": "NCT06589804",
      "title": "Testing the Addition of Anti-Cancer Drug, Cetuximab, to Standard of Care Treatment (Pembrolizumab) for Returning or Spreading Head and Neck Cancer After Previous Treatment",
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      "last_update": "2026-09-08",
      "phase": "PHASE3",
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     {
      "nct": "NCT06636734",
      "title": "Lovastatin and Pembrolizumab for the Treatment of Patients With Recurrent or Metastatic Head and Neck Cancer, LAPP Trial",
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      "last_update": "2026-02-11",
      "phase": "PHASE2",
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     {
      "nct": "NCT06638931",
      "title": "Agnostic Therapy in Rare Solid Tumors",
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      "last_update": "2026-04-15",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06699212",
      "title": "A Study of ASP-1929 Photoimmunotherapy in Combination With Pembrolizumab in First-line Treatment of Locoregional Recurrent Squamous Cell Carcinoma of the Head and Neck With No Distant Metastases",
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      "last_update": "2025-10-15",
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      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06749899",
      "title": "QL1706 (PD-1/CTLA-4 Bi-specific Antibody) and Chemoradiotherapy in Locoregionally-advanced Nasopharyngeal Carcinoma.",
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      "last_update": "2025-05-22",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06769698",
      "title": "A Study to See if Giving Fianlimab and Cemiplimab Together is Better Than Cemiplimab Alone at Treating Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma",
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      "last_update": "2026-08-21",
      "phase": "PHASE2",
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     {
      "nct": "NCT06773507",
      "title": "Phase I Study of BC008-1A Injection in Patients With Advanced Solid Tumors",
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      "last_update": "2025-07-09",
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     {
      "nct": "NCT06787911",
      "title": "Donafenib Combined With Anti-PD-1 Antibody for Neoadjuvant Therapy in Locally Advanced Thyroid Cancer",
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      "last_update": "2025-01-22",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06788990",
      "title": "FORTIFI-HN01: A Study of Ficerafusp Alfa (BCA101) or Placebo in Combination With Pembrolizumab in First-Line PD-L1-pos, R or M HNSCC",
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      "phase": "PHASE2/PHASE3",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06802835",
      "title": "EGFR Antibody Combined With PD-1 Inhibitor and Chemotherapy in R/M Nasopharyngeal Carcinoma",
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      "last_update": "2026-05-11",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06823479",
      "title": "Towards Cure Via Only Ultra-short ICB in CSCC",
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      "last_update": "2025-05-29",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06868433",
      "title": "TMV Vaccine Therapy Alone and With Pembrolizumab for the Treatment of Recurrent and/or Metastatic Head and Neck Squamous Cell Cancer",
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      "phase": "PHASE1",
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     {
      "nct": "NCT06902376",
      "title": "XL092 and Cemiplimab in BRAF WT Thyroid Cancer",
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      "last_update": "2026-09-08",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06907602",
      "title": "Optimizing Neoadjuvant Treatment Regimens for Locally Advanced Esophageal Squamous Cell Carcinoma",
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      "last_update": "2025-04-02",
      "phase": "PHASE2/PHASE3",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06912087",
      "title": "Dose Finding Study of Zanzalintinib With Pembrolizumab and Cetuximab in Head and Neck SCC",
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      "phase": "PHASE1",
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     {
      "nct": "NCT06923761",
      "title": "EMITT-1 (ERAP Mediated Immunopeptidome Targeting Trial - 1)",
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      "last_update": "2026-01-28",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06980038",
      "title": "Testing Whether Cemiplimab (REGN2810) Plus CDX-1140 Given Prior to Surgery Are Better Than Cemiplimab (REGN2810) Alone in Patients With Stage III-IV Head and Neck Cancer",
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      "last_update": "2026-09-08",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT07000253",
      "title": "Timing of Comprehensive Local Treatment After First-Line Systemic Therapy in Oligometastatic Esophageal or Gastric Adenocarcinoma",
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      "last_update": "2026-09-10",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT07040072",
      "title": "Finotonlimab Combined With Stapokibart in the Treatment of Recurrent/Metastatic HNSCC",
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      "last_update": "2026-05-04",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT07071103",
      "title": "Intestinal Low Dose Radiotherapy Combined With Immunotherapy in Immune-resistant Metastatic Malignant Solid Tumors",
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      "last_update": "2025-11-20",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT07152678",
      "title": "Brachytherapy With Radiotherapy and Immunotherapy: Guided HDR Trial in Esophageal Squamous Cell Carcinoma",
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      "last_update": "2025-09-03",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT07172256",
      "title": "CUE-101with Pembrolizumab for Locally Advanced HPV+HNSCCs",
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      "last_update": "2026-07-30",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT07179315",
      "title": "A Study Comparing Two Immunotherapy Options for Human Papillomavirus Positive HPV-Positive Head and Neck Cancer After Treatment",
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      "last_update": "2026-07-16",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT07195734",
      "title": "Testing the Addition of Chemotherapy or Chemo-Immunotherapy to the Usual Surgery for Advanced Head and Neck Cancer",
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      "last_update": "2026-09-11",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT07205731",
      "title": "Phase II Study Evaluating Safety and Efficacy of Tislelizumab for Elderly Patients Unfit for Chemotherapy, With Advanced Esophageal Squamous-cell Carcinoma",
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      "last_update": "2026-05-20",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT07213934",
      "title": "Phase I/ II Trial Combining PD-1 Inhibition and Neoadjuvant Proton or Photon Radiation Therapy in Recurrent Head and Neck Squamous Cell Carcinoma",
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      "last_update": "2026-07-01",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT07223424",
      "title": "Patient Preference for Subcutaneous vs. Intravenous Immune Therapy",
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      "last_update": "2026-04-16",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT07254585",
      "title": "SYS6010 Combined With Enlonstobart In Recurrent Or Metastatic Head And Neck Squamous Cell Carcinoma",
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      "last_update": "2026-01-26",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT07277764",
      "title": "Induction High-Low Dose Radiotherapy Plus Anti-PD-1 Followed by Definitive Radiotherapy in Recurrent Nasopharyngeal Carcinoma (Single-Arm Phase II)",
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      "last_update": "2025-12-11",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT07290010",
      "title": "The Efficacy and Safety of Iparomlimab and Tuvonralimab Injection Combined With Chemotherapy as the First-line Treatment for Esophageal Squamous Cell Carcinoma",
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      "last_update": "2025-12-17",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT07317609",
      "title": "Neoadjuvant Immunotherapy Combined With Chemotherapy Sequenced With Endoscopic Resection for Esophageal Cancer (Endosurgery-02)",
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      "last_update": "2026-01-05",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT07332247",
      "title": "PD-1 Inhibitor Plus Chemotherapy Followed by Immediate Versus Selective Re-irradiation for Locally Advanced Recurrent NPC",
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      "last_update": "2026-02-04",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT07339488",
      "title": "Intestinal Low-Dose Radiotherapy Plus Immunochemotherapy for Conversion of Borderline Resectable/Unresectable Esophageal Squamous Cell Carcinoma",
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      "last_update": "2026-06-18",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT07343596",
      "title": "Study to Identify Biomarkers of Oral Cavity Cancer Response to Neoadjuvant Immunotherapy Prior to Definitive Surgery",
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      "last_update": "2026-08-10",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT07403136",
      "title": "Becotatug Vedotin \u00b1 Anti-PD-1 in Pretreated Advanced ESCC",
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      "last_update": "2026-07-07",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT07405151",
      "title": "A Clinical Trial of Ifinatamab Deruxtecan in People With Advanced Esophageal Cancer (MK-3475-06F)",
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      "last_update": "2026-09-03",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT07408063",
      "title": "A Comprehensive Multiomic Biomarker Evaluation Across Two Single-arm Cohorts to Elucidate Mechanisms of Response and Resistance in Recurrent/Metastatic (R/M) Head and Neck Squamous Cell Carcinoma (HNSCC)",
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      "last_update": "2026-04-29",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT07410676",
      "title": "EBNK-001 Allogeneic NK Cells With Low-Dose IL-15 \u00b1 Pembrolizumab in Advanced Solid Tumors",
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      "last_update": "2026-02-18",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT07423078",
      "title": "Window of Opportunity in Preserving Laryngeal Function Trial",
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      "last_update": "2026-04-13",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT07431281",
      "title": "Sonesitatug Vedotin in Combination With Capecitabine With or Without Rilvegostomig in Participants With Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma Expressing Claudin18.2",
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      "last_update": "2026-09-09",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT07455019",
      "title": "A Study of Bemosubaiabimab Combined With Anlotinib and Radiotherapy and Chemotherapy for the Treatment of Oligometastatic Esophageal Cancer",
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      "last_update": "2026-03-06",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT07460765",
      "title": "Safety and Feasibility of Nivolumab-IRDye800CW in Patients With Head and Neck Squamous Cell Carcinoma (HNSCC)",
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      "last_update": "2026-07-07",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT07485296",
      "title": "Effect of Postbiotics on Microbiota and Systemic Immunomodulation of Pembrolizumab as First-Line Therapy in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma (RM HNSCC)",
      "status": "RECRUITING",
      "last_update": "2026-03-20",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07501650",
      "title": "Pembrolizumab Plus Ultrasound-Induced Microbubble Cavitation in Head and Neck Cancer",
      "status": "RECRUITING",
      "last_update": "2026-03-30",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07559045",
      "title": "Induction Chemo-Immunotherapy + Radiotherapy vs Concurrent Chemoradiotherapy for Unresectable Locally Advanced Esophageal Squamous Cell Carcinoma",
      "status": "RECRUITING",
      "last_update": "2026-04-30",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07629817",
      "title": "Surgery vs. Radical Chemoradiotherapy for Esophageal SCC After Neoadjuvant Immunochemotherapy",
      "status": "RECRUITING",
      "last_update": "2026-07-31",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07781358",
      "title": "Becotatug Vedotin Combined With a PD-1 Inhibitor in the Treatment of Locally Advanced Recurrent Nasopharyngeal Carcinoma.",
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      "last_update": "2026-08-24",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01818323",
      "title": "Phase I Trial: T4 Immunotherapy of Head and Neck Cancer",
      "status": "UNKNOWN",
      "last_update": "2024-10-09",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02105636",
      "title": "Trial of Nivolumab vs Therapy of Investigator's Choice in Recurrent or Metastatic Head and Neck Carcinoma (CheckMate 141)",
      "status": "COMPLETED",
      "last_update": "2022-10-05",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02124850",
      "title": "A Phase Ib Study of Neoadjuvant of Cetuximab Plus Motolimod and Cetuximab Plus Motolimod Plus Nivolumab",
      "status": "TERMINATED",
      "last_update": "2019-10-25",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02335918",
      "title": "A Dose Escalation and Cohort Expansion Study of Anti-CD27 (Varlilumab) and Anti-PD-1 (Nivolumab) in Advanced Refractory Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2019-12-09",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02376699",
      "title": "Safety Study of SEA-CD40 in Cancer Patients",
      "status": "TERMINATED",
      "last_update": "2023-05-01",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02423863",
      "title": "In Situ, Autologous Therapeutic Vaccination Against Solid Cancers With Intratumoral Hiltonol\u00ae",
      "status": "COMPLETED",
      "last_update": "2020-12-17",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02465060",
      "title": "Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-08-28",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02475213",
      "title": "Safety Study of Enoblituzumab (MGA271) in Combination With Pembrolizumab or MGA012 in Refractory Cancer",
      "status": "COMPLETED",
      "last_update": "2025-08-11",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02526017",
      "title": "Study of Cabiralizumab in Combination With Nivolumab in Patients With Selected Advanced Cancers",
      "status": "COMPLETED",
      "last_update": "2022-03-09",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02538510",
      "title": "Pembrolizumab and Vorinostat in Treating Patients With Recurrent Squamous Cell Head and Neck Cancer or Salivary Gland Cancer That Is Metastatic and/or Cannot Be Removed by Surgery",
      "status": "COMPLETED",
      "last_update": "2024-11-26",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02559687",
      "title": "Study of Pembrolizumab (MK-3475) in Previously-Treated Participants With Advanced Carcinoma of the Esophagus or Esophagogastric Junction (MK-3475-180/KEYNOTE-180)",
      "status": "COMPLETED",
      "last_update": "2022-09-14",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02569242",
      "title": "Study of Nivolumab in Unresectable Advanced or Recurrent Esophageal Cancer",
      "status": "COMPLETED",
      "last_update": "2022-07-06",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02575404",
      "title": "GR-MD-02 Plus Pembrolizumab in Melanoma, Non-small Cell Lung Cancer, and Squamous Cell Head and Neck Cancer Patients",
      "status": "COMPLETED",
      "last_update": "2023-06-05",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02609503",
      "title": "Pembrolizumab + Radiation for Locally Adv SCC of the Head and Neck (SCCHN) Not Eligible Cisplatin",
      "status": "COMPLETED",
      "last_update": "2024-11-05",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02626000",
      "title": "Talimogene Laherparepvec With Pembrolizumab for Recurrent Metastatic Squamous Cell Carcinoma of the Head and Neck (MASTERKEY232 / KEYNOTE-137)",
      "status": "COMPLETED",
      "last_update": "2021-09-08",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02636036",
      "title": "Phase I Study of Enadenotucirev and PD-1 Inhibitor in Subjects With Metastatic or Advanced Epithelial Tumors",
      "status": "COMPLETED",
      "last_update": "2021-11-09",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02637531",
      "title": "A Dose-Escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of IPI-549",
      "status": "UNKNOWN",
      "last_update": "2022-04-04",
      "phase": "PHASE1",
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     {
      "nct": "NCT02641093",
      "title": "Phase II Trial of Adjuvant Cisplatin and Radiation With Pembrolizumab in Resected Head and Neck Squamous Cell Carcinoma",
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      "last_update": "2026-05-04",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT02684253",
      "title": "Screening Trial of Nivolumab With Image Guided, Stereotactic Body Radiotherapy (SBRT) Versus Nivolumab Alone in Patients With Metastatic Head and Neck Squamous Cell Carcinoma (HNSCC)",
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      "last_update": "2022-03-10",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT02707588",
      "title": "Tolerance and Efficacy of Pembrolizumab or Cetuximab Combined With RT in Patients With Locally Advanced HNSCC",
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      "last_update": "2023-02-28",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02735239",
      "title": "Study of Anti-PD-L1 in Combination With Chemo(Radio)Therapy for Oesophageal Cancer",
      "status": "COMPLETED",
      "last_update": "2024-03-22",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02741570",
      "title": "Study of Nivolumab in Combination With Ipilimumab Compared to the Standard of Care (Extreme Regimen) as First Line Treatment in Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck",
      "status": "COMPLETED",
      "last_update": "2023-09-21",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02757391",
      "title": "CD8+ T Cell Therapy and Pembrolizumab in Treating Patients With Metastatic Gastrointestinal Tumors",
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      "last_update": "2020-10-30",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02764593",
      "title": "Safety Testing of Adding Nivolumab to Chemotherapy in Patients With Intermediate and High-Risk Local-Regionally Advanced Head and Neck Cancer",
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      "last_update": "2022-11-29",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02775812",
      "title": "Cisplatin, Intensity-Modulated Radiation Therapy, and Pembrolizumab in Treating Patients With Stage III-IV Head and Neck Squamous Cell Carcinoma",
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      "last_update": "2022-06-10",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02799095",
      "title": "A Study of the Effects of ALKS 4230 (Nemvaleukin Alfa) on Subjects With Solid Tumors",
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      "last_update": "2025-05-21",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02823574",
      "title": "Study of Nivolumab in Combination With Ipilimumab Versus Nivolumab in Combination With Ipilimumab Placebo in Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck",
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      "last_update": "2023-05-03",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02829931",
      "title": "Hypofractionated Stereotactic Irradiation With Nivolumab, Ipilimumab and Bevacizumab in Patients With Recurrent High Grade Gliomas",
      "status": "COMPLETED",
      "last_update": "2023-01-19",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02830594",
      "title": "Pembrolizumab and Palliative Radiation Therapy in Treating Patients With Metastatic Esophagus, Stomach, or Gastroesophageal Junction Cancer",
      "status": "COMPLETED",
      "last_update": "2024-02-20",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02834013",
      "title": "Nivolumab and Ipilimumab in Treating Patients With Rare Tumors",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-06-17",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02834247",
      "title": "A Study of TAK-659 in Combination With Nivolumab in Participants With Advanced Solid Tumors",
      "status": "TERMINATED",
      "last_update": "2023-02-08",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02841748",
      "title": "A Randomized, Double-Blind Phase II Study of Adjuvant Pembrolizumab Versus Placebo in Head and Neck Cancers at High Risk for Recurrence- the PATHWay Study",
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      "last_update": "2026-05-13",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02842125",
      "title": "Safety and Efficacy of Intra-Arterial and Intra-Tumoral Ad-p53 With Capecitabine (Xeloda) or Anti-PD-1 in Liver Metastases of Solid Tumors and Recurrent Head and Neck Squamous Cell Cancer",
      "status": "TERMINATED",
      "last_update": "2020-06-02",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02882282",
      "title": "Pembrolizumab in Treating Patients With High Risk Oral Intraepithelial Neoplasia",
      "status": "COMPLETED",
      "last_update": "2025-10-23",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02903914",
      "title": "Arginase Inhibitor INCB001158 as a Single Agent and in Combination With Immune Checkpoint Therapy in Patients With Advanced/Metastatic Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2025-08-05",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02915432",
      "title": "The Study to Evaluate Toripalimab (JS001) in Patients With Advanced GC, ESCC, NPC, HNSCC",
      "status": "UNKNOWN",
      "last_update": "2021-12-13",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02946671",
      "title": "Study of Pre-operative Combination Therapy With Mogamulizumab and Nivolumab Against Solid Cancer Patients",
      "status": "COMPLETED",
      "last_update": "2020-03-06",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02952989",
      "title": "A Safety Study of SGN-2FF for Patients With Advanced Solid Tumors",
      "status": "TERMINATED",
      "last_update": "2019-07-19",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02955290",
      "title": "CIMAvax Vaccine, Nivolumab, and Pembrolizumab in Treating Patients With Advanced Non-small Cell Lung Cancer or Squamous Head and Neck Cancer",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-08-10",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02971956",
      "title": "Pembrolizumab in Refractory Advanced Esophageal Cancer",
      "status": "COMPLETED",
      "last_update": "2023-09-21",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02973997",
      "title": "Lenvatinib and Pembrolizumab in Differentiated Thyroid Cancers (DTC)",
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      "last_update": "2025-08-29",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03003637",
      "title": "ImmunoModulation by the Combination of Ipilimumab and Nivolumab Neoadjuvant to Surgery In Advanced or Recurrent Head and Neck Carcinoma",
      "status": "COMPLETED",
      "last_update": "2023-10-23",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03006887",
      "title": "Phase 1b Trial of Lenvatinib Plus Pembrolizumab in Participants With Selected Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2021-05-20",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03012581",
      "title": "Secured Access to Nivolumab for Adult Patients With Selected Rare Cancer Types",
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      "last_update": "2024-02-28",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03021993",
      "title": "Trial of Nivolumab as a Novel Neoadjuvant Pre-Surgical Therapy for Locally Advanced Oral Cavity Cancer",
      "status": "COMPLETED",
      "last_update": "2025-11-12",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03040999",
      "title": "Study of Pembrolizumab (MK-3475) or Placebo With Chemoradiation in Participants With Locally Advanced Head and Neck Squamous Cell Carcinoma (MK-3475-412/KEYNOTE-412)",
      "status": "COMPLETED",
      "last_update": "2026-02-04",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03044613",
      "title": "Nivolumab +/- Relatlimab Prior to Chemoradiation With II/III Gastro/Esophageal Cancer",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-03-23",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03058289",
      "title": "A Phase 1/2 Safety Study of Intratumorally Dosed INT230-6",
      "status": "COMPLETED",
      "last_update": "2025-02-27",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03097939",
      "title": "Phase 2 Trial of Ipilimumab and Nivolumab in Nasopharyngeal Carcinoma",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-06-22",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03099382",
      "title": "Study of SHR-1210 Versus Investigator's Choice of Chemotherapy for Participants With Advanced Esophageal Cancer",
      "status": "COMPLETED",
      "last_update": "2024-01-22",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03107182",
      "title": "Chemotherapy and Locoregional Therapy Trial (Surgery or Radiation) for Patients With Head and Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2025-05-06",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03121716",
      "title": "A Study to Evaluate the Safety and Efficacy of SHR-1210, Gemcitabine and Cis-platinum by R/M NPC Subjects",
      "status": "COMPLETED",
      "last_update": "2022-07-12",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03126110",
      "title": "Phase 1/2 Study Exploring the Safety, Tolerability, and Efficacy of INCAGN01876 Combined With Immune Therapies in Advanced or Metastatic Malignancies",
      "status": "COMPLETED",
      "last_update": "2025-08-14",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03129061",
      "title": "Study to Evaluate Immunological Response to PD-1 Inhibition in Squamous Cell Carcinoma of the Head and Neck (SCCHN)",
      "status": "COMPLETED",
      "last_update": "2022-12-05",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03132038",
      "title": "Nivolumab in Recurrent or Metastatic Salivary Gland Carcinoma of the Head and Neck",
      "status": "COMPLETED",
      "last_update": "2022-01-11",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03162731",
      "title": "Nivolumab, Ipilimumab, and Radiation Therapy in Treating Patients With Stage III-IVB Head and Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2025-04-29",
      "phase": "EARLY_PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03170960",
      "title": "Study of Cabozantinib Alone or in Combination With Atezolizumab to Subjects With Locally Advanced or Metastatic Solid Tumors",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-08-17",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03189719",
      "title": "First-line Esophageal Carcinoma Study With Pembrolizumab Plus Chemo vs. Chemo (MK-3475-590/KEYNOTE-590)",
      "status": "COMPLETED",
      "last_update": "2024-10-15",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03196232",
      "title": "Epacadostat and Pembrolizumab in Treating Patients With Metastatic or Unresectable Gastroesophageal Junction or Gastric Cancer",
      "status": "COMPLETED",
      "last_update": "2024-01-23",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03198130",
      "title": "An Exploratory Tumor Biopsy-driven Study to Understand the Relationship Between Biomarkers and Clinical Response in Patients With Head and Neck Cancer Receiving REGN2810 (Anti-PD-1)",
      "status": "COMPLETED",
      "last_update": "2020-03-19",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03229278",
      "title": "Trigriluzole With Nivolumab and Pembrolizumab in Treating Patients With Metastatic or Unresectable Solid Malignancies or Lymphoma",
      "status": "COMPLETED",
      "last_update": "2023-12-06",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03236935",
      "title": "Phase Ib of L-NMMA and Pembrolizumab",
      "status": "COMPLETED",
      "last_update": "2026-04-09",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03238638",
      "title": "A Study of Epacadostat + Pembrolizumab in Head and Neck Cancer Patients, Who Failed Prior PD-1/PD-L1 Therapy",
      "status": "WITHDRAWN",
      "last_update": "2018-01-04",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03241173",
      "title": "A Study Exploring the Safety and Efficacy of INCAGN01949 in Combination With Immune Therapies in Advanced or Metastatic Malignancies",
      "status": "COMPLETED",
      "last_update": "2022-09-27",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03246958",
      "title": "Nivolumab Plus Ipilimumab in Thyroid Cancer",
      "status": "COMPLETED",
      "last_update": "2025-06-19",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03247712",
      "title": "Neoadjuvant Immunoradiotherapy in Head & Neck Cancer",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-07-23",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03267498",
      "title": "Nivolumab + Chemoradiation in Stage II-IVB Nasopharyngeal Carcinoma (NPC)",
      "status": "COMPLETED",
      "last_update": "2026-01-12",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03278626",
      "title": "Immune Checkpoint Therapy With Nivolumab Esophageal Squamous Cell Carcinoma",
      "status": "TERMINATED",
      "last_update": "2022-03-28",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03291002",
      "title": "Study of Intratumoral CV8102 in cMEL, cSCC, hnSCC, and ACC",
      "status": "UNKNOWN",
      "last_update": "2021-11-04",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03313804",
      "title": "Priming Immunotherapy in Advanced Disease With Radiation",
      "status": "COMPLETED",
      "last_update": "2026-03-11",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03317327",
      "title": "REirradiation and Programmed Cell Death Protein 1 (PD-1) Blockade On Recurrent Squamous Cell Head and Neck Tumors",
      "status": "COMPLETED",
      "last_update": "2025-06-03",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03329950",
      "title": "A Study of CDX-1140 (CD40) as Monotherapy or in Combination in Patients With Advanced Malignancies",
      "status": "COMPLETED",
      "last_update": "2024-03-28",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03342352",
      "title": "Nivolumab Plus Epacadostat in Combination With Chemotherapy Versus the EXTREME Regimen in Squamous Cell Carcinoma of the Head and Neck (CheckMate 9NA/ECHO-310)",
      "status": "WITHDRAWN",
      "last_update": "2019-12-20",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03342911",
      "title": "Nivolumab, Carboplatin, and Paclitaxel in Treating Patients With Stage III-IV Head and Neck Squamous Cell Carcinoma That Can Be Removed by Surgery",
      "status": "COMPLETED",
      "last_update": "2025-04-24",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03342937",
      "title": "KeyLargo: Pembrolizumab + Oxaliplatin + Capecitabine in Gastric Cancer",
      "status": "COMPLETED",
      "last_update": "2024-03-13",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03347123",
      "title": "A Study of Epacadostat and Nivolumab in Combination With Immune Therapies in Participants With Advanced or Metastatic Malignancies (ECHO-208)",
      "status": "TERMINATED",
      "last_update": "2022-02-28",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03347838",
      "title": "Nivolumab for the Reversal of Squamous Dysplasia in High Risk Current and Former Smokers",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-12-12",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03349710",
      "title": "Nivolumab or Nivolumab Plus Cisplatin, in Combination With Radiotherapy in Patients With Cisplatin-ineligible or Eligible Locally Advanced Squamous Cell Head and Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2021-08-09",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03355560",
      "title": "Adjuvant Nivolumab After Salvage Resection in Head and Neck Cancer Patients Previously Treated With Definitive Therapy",
      "status": "COMPLETED",
      "last_update": "2026-05-06",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03360890",
      "title": "Pembrolizumab With Chemotherapy for Poorly Chemo-responsive Thyroid and Salivary Gland Tumors",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-03-13",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03370276",
      "title": "Cetuximab & Nivolumab in Patients With Recurrent/Metastatic Head & Neck Squamous Cell Carcinoma",
      "status": "COMPLETED",
      "last_update": "2026-04-02",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03383094",
      "title": "Chemoradiation vs Immunotherapy and Radiation for Head and Neck Cancer",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-10-07",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03386357",
      "title": "Radiotherapy With Pembrolizumab in Metastatic Head and Neck Squamous Cell Carcinoma (HNSCC)",
      "status": "TERMINATED",
      "last_update": "2026-03-27",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03386838",
      "title": "An Immuno-therapy Study of Nivolumab in Combination With Experimental Medication BMS-986205 Compared to Standard of Care EXTREME Regimen in First-line Recurrent/Metastatic Squamous Cell Carcinoma of Head and Neck",
      "status": "WITHDRAWN",
      "last_update": "2019-04-18",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03390738",
      "title": "Nivolumab as Treatment for Recurrent/Metastatic Nasopharyngeal Carcinoma After Failing 2 Lines or More Previous Chemotherapy",
      "status": "WITHDRAWN",
      "last_update": "2021-05-03",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03402737",
      "title": "SBRT + Immunomodulating Systemic Therapy for Inoperable, Recurrent H&N",
      "status": "TERMINATED",
      "last_update": "2021-02-18",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03409848",
      "title": "Ipilimumab or FOLFOX in Combination With Nivolumab and Trastuzumab in HER2 Positive EsophagoGastric Adenocarcinoma",
      "status": "COMPLETED",
      "last_update": "2022-05-18",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03412058",
      "title": "Identifying the Predictive Factors of Response to PD-1 or PD-L1 Antagonists",
      "status": "TERMINATED",
      "last_update": "2026-08-03",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03416244",
      "title": "A Multicenter Open-label Phase II Trial to Evaluate Nivolumab and Ipilimumab for 2nd Line Therapy in Elderly Patients With Advanced Esophageal Squamous Cell Cancer",
      "status": "COMPLETED",
      "last_update": "2022-09-29",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03427827",
      "title": "PD-1 Antibody Versus Best Supportive Care After Chemoradiation in Locoregionally Advanced Nasopharyngeal Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2024-04-09",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03435640",
      "title": "REVEAL Study of NKTR-262 in Combination With NKTR-214 and Nivolumab in Patients With Locally Advanced / Metastatic Solid Tumor Malignancies",
      "status": "TERMINATED",
      "last_update": "2023-03-08",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03463161",
      "title": "Epacadostat and Pembrolizumab in Patients With Head and Neck Cancer That Have Failed Prior Immunotherapy",
      "status": "TERMINATED",
      "last_update": "2020-01-27",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03469557",
      "title": "BGB A317 in Combination With Chemotherapy as First-Line Treatment in Adults With Inoperable, Locally Advanced or Metastatic Esophageal, Gastric, or Gastroesophageal Junction Carcinoma",
      "status": "COMPLETED",
      "last_update": "2024-10-23",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03474497",
      "title": "UCDCC#272: IL-2, Radiotherapy, and Pembrolizumab in Patients Refractory to Checkpoint Blockade",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-01-29",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03511391",
      "title": "CHEckpoint Inhibition in Combination With an Immunoboost of External Beam Radiotherapy in Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2024-01-23",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03521570",
      "title": "Intensity-Modulated Radiation Therapy & Nivolumab for Recurrent or Second Primary Head & Neck Squamous Cell Cancer",
      "status": "COMPLETED",
      "last_update": "2024-09-19",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03544723",
      "title": "Safety and Efficacy of p53 Gene Therapy Combined With Immune Checkpoint Inhibitors in Solid Tumors.",
      "status": "UNKNOWN",
      "last_update": "2020-06-09",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03544736",
      "title": "Safety and Feasibility of Irradiation and Nivolumab in Esophageal Cancer (INEC)",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2023-03-22",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03565445",
      "title": "A Study of ASP1948, Targeting an Immune Modulatory Receptor as a Single Agent and in Combination With a PD-l Inhibitor (Nivolumab or Pembrolizumab) in Subjects With Advanced Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2024-11-01",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03565783",
      "title": "Cemiplimab in Treating Patients With Recurrent and Resectable Stage II-IV Head and Neck Cutaneous Squamous Cell Cancer Before Surgery",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-07-16",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03575234",
      "title": "Nivolumab & IRX-2 With Surgery for Resectable Stage III-IVA Oral Cavity Cancer or HPV-Positive Oropharyngeal Cancer",
      "status": "WITHDRAWN",
      "last_update": "2019-08-28",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03575598",
      "title": "Sitravatinib (MGCD516) and Nivolumab in Oral Cavity Cancer Window Opportunity Study",
      "status": "COMPLETED",
      "last_update": "2023-07-27",
      "phase": "EARLY_PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03576417",
      "title": "A Trial Evaluating the Addition of Nivolumab to Cisplatin-RT for Treatment of Cancers of the Head and Neck",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-05-07",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03578406",
      "title": "HPV-E6-Specific Anti-PD1 TCR-T Cells in the Treatment of HPV-Positive NHSCC or Cervical Cancer",
      "status": "COMPLETED",
      "last_update": "2026-01-21",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03592407",
      "title": "Epacadostat and Pembrolizumab Before Surgery in Treating Participants With Stage II-III Esophageal or Gastroesophageal Cancer",
      "status": "WITHDRAWN",
      "last_update": "2022-03-08",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03620123",
      "title": "A Randomized Phase II Study on the Optimization of Immunotherapy in Squamous Carcinoma of the Head and Neck",
      "status": "COMPLETED",
      "last_update": "2022-11-18",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03621982",
      "title": "Study of ADCT-301 in Patients With Selected Advanced Solid Tumors",
      "status": "TERMINATED",
      "last_update": "2024-06-13",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03625323",
      "title": "Combination Study With Soluble LAG-3 Fusion Protein Eftilagimod Alpha (IMP321) and Pembrolizumab in Patients With Previously Untreated Unresectable or Metastatic NSCLC, or Recurrent PD-X Refractory NSCLC or With Recurrent or Metastatic HNSCC",
      "status": "COMPLETED",
      "last_update": "2026-04-22",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03629756",
      "title": "A Study to Evaluate the Safety and Tolerability of Immunotherapy Combinations in Participants With Advanced Malignancies",
      "status": "COMPLETED",
      "last_update": "2024-05-24",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03633110",
      "title": "Safety, Tolerability, Immunogenicity, and Antitumor Activity of GEN-009 Adjuvanted Vaccine",
      "status": "COMPLETED",
      "last_update": "2022-04-19",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03645928",
      "title": "Study of Autologous Tumor Infiltrating Lymphocytes in Patients With Solid Tumors",
      "status": "TERMINATED",
      "last_update": "2026-05-15",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03646461",
      "title": "Trial of Ibrutinib Combined With Nivolumab or Cetuximab to Treat Recurrent/Metastatic HNSCC",
      "status": "TERMINATED",
      "last_update": "2026-05-22",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03652233",
      "title": "Afatinib and Nivolumab as Treatment for Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck",
      "status": "WITHDRAWN",
      "last_update": "2019-06-20",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03655444",
      "title": "Abemaciclib + Nivolumab in Patients With Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma That Progressed or Recurred Within Six Months After Platinum-based Chemotherapy",
      "status": "TERMINATED",
      "last_update": "2020-12-03",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03669718",
      "title": "A Randomized Phase 2 Study of Cemiplimab \u00b1 ISA101b in HPV16-Positive OPC",
      "status": "UNKNOWN",
      "last_update": "2023-12-29",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03674567",
      "title": "Dose Escalation and Expansion Study of FLX475 Monotherapy and in Combination With Pembrolizumab",
      "status": "COMPLETED",
      "last_update": "2026-09-03",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03684785",
      "title": "Intratumoral Cavrotolimod Combined With Pembrolizumab or Cemiplimab in Patients With Merkel Cell Carcinoma, Cutaneous Squamous Cell Carcinoma, or Other Advanced Solid Tumors",
      "status": "TERMINATED",
      "last_update": "2022-04-07",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03690986",
      "title": "VX15/2503 in Combination With Ipilimumab or Nivolumab in Patients With Head and Neck Cancer",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-07-16",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03692325",
      "title": "Safety and Efficacy of Nivolumab in Treating Oral Proliferative Verrucous Leukoplakia",
      "status": "COMPLETED",
      "last_update": "2024-10-01",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03693014",
      "title": "A Study of Several Radiation Doses for Patients With Progression on Immunotherapy/Checkpoint Inhibitors",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-07-24",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03706326",
      "title": "CAR T and PD-1 Knockout Engineered T Cells for Esophageal Cancer",
      "status": "UNKNOWN",
      "last_update": "2018-10-16",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03707509",
      "title": "Phase III Study of Camrelizumab in Combination With Chemotherapy in Recurrent/Metastatic Nasopharyngeal Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2022-07-01",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03708328",
      "title": "A Dose Escalation and Expansion Study of Lomvastomig, a PD-1/TIM-3 Bispecific Antibody, in Participants With Advanced and/or Metastatic Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2025-08-20",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03715946",
      "title": "Adjuvant De-Escalated Radiation + Adjuvant Nivolumab for Intermediate-High Risk P16+ Oropharynx Cancer",
      "status": "COMPLETED",
      "last_update": "2025-01-13",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03721757",
      "title": "CA209-891: Neoadjuvant and Adjuvant Nivolumab as Immune Checkpoint Inhibition in Oral Cavity Cancer",
      "status": "COMPLETED",
      "last_update": "2025-02-25",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03727061",
      "title": "Porfimer Sodium Interstitial Photodynamic Therapy With or Without Standard of Care Chemotherapy in Treating Patients With Locally Advanced or Recurrent Head and Neck Cancer",
      "status": "TERMINATED",
      "last_update": "2025-03-11",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03735290",
      "title": "A Study to Evaluate the Safety and Effectiveness of ILIxadencel Administered Into Tumors in Combination With Checkpoint Inhibitor (CPI) in Patients With ADvanced Cancer",
      "status": "TERMINATED",
      "last_update": "2022-03-16",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03735628",
      "title": "An Study to Evaluate the Safety and Efficacy of Copanlisib in Combination With Nivolumab in Patients With Advanced Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2023-10-06",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03749460",
      "title": "Nivolumab and Ipilimumab and Stereotactic Body Radiation Therapy in Treating Patients With Salivary Gland Cancers",
      "status": "COMPLETED",
      "last_update": "2023-12-29",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03758729",
      "title": "Phase II Study of Nivolumab in Combination With Radiation Therapy as Definitive Treatment for Patients With Locally Advanced, Unresectable Head and Neck Mucosal Melanoma.",
      "status": "WITHDRAWN",
      "last_update": "2021-02-16",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03758781",
      "title": "IRX-2 Regimen Combined With Nivolumab in Recurrent/Metastatic Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2023-04-14",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03764553",
      "title": "Liposomal iRInotecan, Carboplatin or oXaliplatin for Esophagogastric Cancer",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-08-21",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03765918",
      "title": "Study of Pembrolizumab Given Prior to Surgery and in Combination With Radiotherapy Given Post-surgery for Advanced Head and Neck Squamous Cell Carcinoma (MK-3475-689)",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-07-31",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03766178",
      "title": "Study of Anti-PD-1 Antibody SHR-1210 Plus Nimotuzumab in the Treatment of Advanced Esophageal Squamous Cell Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2021-07-07",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03769467",
      "title": "Tabelecleucel in Combination With Pembrolizumab in Subjects With Epstein-Barr Virus-associated Nasopharyngeal Carcinoma (EBV+ NPC)",
      "status": "TERMINATED",
      "last_update": "2024-11-14",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03789097",
      "title": "Vaccination With Flt3L, Radiation, and Poly-ICLC",
      "status": "COMPLETED",
      "last_update": "2026-05-22",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03792347",
      "title": "Preoperative Anti-PD-1 Antibody Combined With Chemoradiotherapy for Locally Advanced Squamous Cell Carcinoma of Esophagus",
      "status": "COMPLETED",
      "last_update": "2023-11-22",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03799003",
      "title": "A Study of ASP1951 in Subjects With Advanced Solid Tumors",
      "status": "TERMINATED",
      "last_update": "2024-11-01",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03799445",
      "title": "Ipilimumab, Nivolumab, and Radiation Therapy in Treating Patients With HPV Positive Advanced Oropharyngeal Squamous Cell Carcinoma",
      "status": "TERMINATED",
      "last_update": "2026-04-30",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03809624",
      "title": "Study of INBRX-105 and INBRX-105 With Pembrolizumab in Patients With Solid Tumors Including Head and Neck Cancer",
      "status": "TERMINATED",
      "last_update": "2024-10-23",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03811015",
      "title": "Testing Immunotherapy Versus Observation in Patients With HPV Throat Cancer",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-08-04",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03811652",
      "title": "A Multiple Ascending Dose Study of MEDI7247 in Advanced or Metastatic Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2019-12-30",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03813836",
      "title": "Phase II Trial of Pembrolizumab in Recurrent or Metastatic HNSCC",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2024-11-12",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03823131",
      "title": "Optimizing Antitumor Immunity Using Plasmid Electroporation, Pembrolizumab, and Epacadostat",
      "status": "TERMINATED",
      "last_update": "2023-05-09",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03829436",
      "title": "TPST-1120 as Monotherapy and in Combination With Nivolumab in Subjects With Advanced Cancers",
      "status": "COMPLETED",
      "last_update": "2023-07-03",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03829722",
      "title": "Radiotherapy, Carboplatin/Paclitaxel and Nivolumab for High Risk HPV-related Head and Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2026-01-22",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03841110",
      "title": "FT500 as Monotherapy and in Combination With Immune Checkpoint Inhibitors in Subjects With Advanced Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2023-05-01",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03843515",
      "title": "Neoadjuvant Nivolumab for Oral Cancer Combined With FDG and Anti-PD-L1 PET/CT Imaging for Response Prediction",
      "status": "UNKNOWN",
      "last_update": "2021-10-08",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03854032",
      "title": "Nivolumab and BMS986205 in Treating Patients With Stage II-IV Squamous Cell Cancer of the Head and Neck",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-06-06",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03878979",
      "title": "Preoperative Immune Checkpoint Inhibitor for Patients With Primary Untreated or Recurrent/Metastatic SCCHN",
      "status": "COMPLETED",
      "last_update": "2024-11-21",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03881111",
      "title": "First-line Esophageal Carcinoma Study With Chemo vs. Chemo Plus Pembrolizumab (MK-3475-590/KEYNOTE-590)-China Extension Study",
      "status": "WITHDRAWN",
      "last_update": "2020-02-11",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03894891",
      "title": "Induction TPN Followed by Nivolumab With Radiation in Locoregionally Advanced Laryngeal and Hypopharyngeal Cancer",
      "status": "COMPLETED",
      "last_update": "2023-12-20",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03906526",
      "title": "A Study to Evaluate Immune Biomarker Modulation in Response to VTX-2337 in Combination With an Anti- PD-1 Inhibitor in Head and Neck Cancer",
      "status": "TERMINATED",
      "last_update": "2023-02-24",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03914300",
      "title": "Testing the Combination of Cabozantinib, Nivolumab, and Ipilimumab (CaboNivoIpi) for Advanced Differentiated Thyroid Cancer",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-07-31",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03914443",
      "title": "A Feasibility Trial of Nivolumab With Neoadjuvant CF or DCF Therapy for Locally Advanced Esophageal Carcinoma",
      "status": "COMPLETED",
      "last_update": "2025-05-31",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03916627",
      "title": "Neoadjuvant Cemiplimab for the Treatment of Resectable NSCLC, HCC, and HNSCC in Adult Patients",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-04-06",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03925090",
      "title": "Phase II Trial of Neoadjuvant and Adjuvant Anti-PD-1 Antibody Toripalimab Combined With CCRT in NPC Patients",
      "status": "UNKNOWN",
      "last_update": "2023-07-03",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03933449",
      "title": "Study of Pembrolizumab (MK-3475) Versus Investigator's Choice of Chemotherapy for Participants With Advanced Esophageal/Esophagogastric Junction Carcinoma That Progressed After First-Line Therapy (MK-3475-181/KEYNOTE-181)-China Extension Study",
      "status": "COMPLETED",
      "last_update": "2023-03-29",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03938337",
      "title": "Abemaciclib and Pembrolizumab in Metastatic or Recurrent Head and Neck Cancer",
      "status": "TERMINATED",
      "last_update": "2021-07-09",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03946969",
      "title": "Sintilimab in Combination With Chemotherapy in Neoadjuvant Treatment of Potentially Resectable Esophageal Cancer",
      "status": "UNKNOWN",
      "last_update": "2022-07-19",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03952585",
      "title": "De-intensified Radiation Therapy With Chemotherapy (Cisplatin) or Immunotherapy (Nivolumab) in Treating Patients With Early-Stage, HPV-Positive, Non-Smoking Associated Oropharyngeal Cancer",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-07-02",
      "phase": "PHASE2/PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03970382",
      "title": "A Study of Gene Edited Autologous Neoantigen Targeted TCR T Cells With or Without Anti-PD-1 in Patients With Solid Tumors",
      "status": "SUSPENDED",
      "last_update": "2022-08-18",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03984357",
      "title": "Nivolumab Combined With Chemoradiotherapy Sparing Concurrent Cisplatin in Nasopharyngeal Carcinoma",
      "status": "COMPLETED",
      "last_update": "2025-07-17",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03987815",
      "title": "Neoadjuvant Nivolumab for Operable Esophageal Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2020-12-17",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03993353",
      "title": "Tadalafil and Pembrolizumab in Recurrent or Metastatic Head and Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2026-02-12",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04005170",
      "title": "Combination of Toripalimab and Chemoradiotherapy in Esophageal Cancer",
      "status": "COMPLETED",
      "last_update": "2022-08-23",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04007744",
      "title": "Sonidegib and Pembrolizumab in Treating Patients With Advanced Solid Tumors",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-03-18",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04030455",
      "title": "Cisplatin, Docetaxel, and Pembrolizumab in Treating Patients With Stage II-III Laryngeal Cancer",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-03-09",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04032704",
      "title": "A Study of Ladiratuzumab Vedotin in Advanced Solid Tumors",
      "status": "TERMINATED",
      "last_update": "2025-03-10",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04044859",
      "title": "ADP-A2M4CD8 as Monotherapy or in Combination With Either Nivolumab or Pembrolizumab in HLA-A2+ Subjects With MAGE-A4 Positive Tumors (SURPASS)",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-08-12",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04058145",
      "title": "AMD3100 Plus Pembrolizumab in Immune Checkpoint Blockade Refractory Head and Neck Squamous Cell Carcinoma",
      "status": "WITHDRAWN",
      "last_update": "2020-09-07",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04061980",
      "title": "Encorafenib and Binimetinib With or Without Nivolumab in Treating Patients With Metastatic Radioiodine Refractory BRAF V600 Mutant Thyroid Cancer",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-04-13",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04074967",
      "title": "Study of ARRY-614 Plus Either Nivolumab or Nivolumab+Ipilimumab",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-11-06",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04080804",
      "title": "Study of Safety and Tolerability of Nivolumab Treatment Alone or in Combination With Relatlimab or Ipilimumab in Head and Neck Cancer",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-09-09",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04083599",
      "title": "GEN1042 Safety Trial and Anti-tumor Activity in Participants With Malignant Solid Tumors",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-08-04",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04084951",
      "title": "Study of SQZ-PBMC-HPV in Patients With HPV16+ Recurrent, Locally Advanced or Metastatic Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2023-04-14",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04139057",
      "title": "EBV-Specific Anti-PD1 TCR-T Cells in the Treatment of EBV-Positive NHSCC",
      "status": "COMPLETED",
      "last_update": "2026-01-20",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04140526",
      "title": "Safety, PK and Efficacy of ONC-392 in Monotherapy and in Combination of Anti-PD-1 in Advanced Solid Tumors and NSCLC",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-05-23",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04143984",
      "title": "Carbon-Ion Radiotherapy Plus Camrelizumab for Locally Recurrent Nasopharyngeal Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2022-04-29",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04146181",
      "title": "Safety and Efficacy of SCT-I10A in Head and Neck Squamous Cell Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2019-12-12",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04150900",
      "title": "1922GCCC: Pembro and Bavituximab for Squamous Cell Carcinoma of Head and Neck",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-02-19",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04152018",
      "title": "Study of PF-06940434 in Patients With Advanced or Metastatic Solid Tumors.",
      "status": "TERMINATED",
      "last_update": "2025-05-28",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04154943",
      "title": "Study of Cemiplimab in Patients With Type of Skin Cancer Stage II to IV Cutaneous Squamous Cell Carcinoma",
      "status": "COMPLETED",
      "last_update": "2025-12-23",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04157985",
      "title": "Evaluating Length of Treatment With PD-1/PD-L1 Inhibitor in Advanced Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2025-12-11",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04180371",
      "title": "Study BT5528-100 in Patients With Advanced Solid Tumors Associated With EphA2 Expression",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-11-17",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04187872",
      "title": "LITT and Pembrolizumab in Recurrent Brain Metastasis",
      "status": "TERMINATED",
      "last_update": "2023-12-27",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04195373",
      "title": "A Safety Study of TMV-018 in Patients With Tumors of the Gastrointestinal Tract",
      "status": "WITHDRAWN",
      "last_update": "2020-11-25",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04199104",
      "title": "A Study of Pembrolizumab (MK-3475) With or Without Lenvatinib (E7080/MK-7902) as First Line (1L) Intervention in a Programmed Cell Death-ligand 1 (PD-L1) Selected Population With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma (R/M HNSCC) (MK-7902-010) (KEYNOTE-010)",
      "status": "COMPLETED",
      "last_update": "2026-05-05",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04203719",
      "title": "A Study of Anlotinib and AK105 Injection in Subjects With Advanced Head, Neck and Chest Cancer",
      "status": "UNKNOWN",
      "last_update": "2020-06-23",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04209660",
      "title": "Lenvatinib and Pembrolizumab in People With Advanced Adenoid Cystic Carcinoma and Other Salivary Gland Cancers",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-10-07",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04222972",
      "title": "A Study of Pralsetinib Versus Standard of Care for First-Line Treatment of Advanced Non-Small Cell Lung Cancer (NSCLC)",
      "status": "TERMINATED",
      "last_update": "2026-03-05",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04229459",
      "title": "Trial of Nivolumab and Cetuximab After Chemoradiation in Esophageal Squamous Cell Carcinoma Patients.",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-01-14",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04238624",
      "title": "Study of Cemiplimab Combined With Dabrafenib and Trametinib in People With Anaplastic Thyroid Cancer",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-07-06",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04260126",
      "title": "Study of PDS0101 and Pembrolizumab Combination I/O in Subjects With HPV16 + Recurrent and/or Metastatic HNSCC",
      "status": "COMPLETED",
      "last_update": "2025-10-01",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04266730",
      "title": "Trial of a Personalized and Adaptive Neoantigen Dose-Adjusted Vaccine Concurrently With Pembrolizumab",
      "status": "SUSPENDED",
      "last_update": "2026-04-23",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04278144",
      "title": "A First-in-human Study Using BDC-1001 as a Single Agent and in Combination With Nivolumab in Advanced HER2-Expressing Solid Tumors",
      "status": "TERMINATED",
      "last_update": "2025-09-15",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04282109",
      "title": "Study to Assess the Efficacy and Safety of Nivolumab in Combination With Paclitaxel in Subjects With Head and Neck Cancer Unable for Cisplatin-based Chemotherapy (NIVOTAX)",
      "status": "COMPLETED",
      "last_update": "2025-06-26",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04291105",
      "title": "Phase 2 Trial of Voyager V1 in Combination With Cemiplimab in Cancer Patients",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-07-08",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04305795",
      "title": "An Open-label Study Using ASP-1929 Photoimmunotherapy in Combination With Anti-PD1 Therapy in EGFR Expressing Advanced Solid Tumors",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-06-19",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04326257",
      "title": "Personalized Immunotherapy in Patients With Recurrent /Metastatic SCCHN That Have Progressed on Prior Immunotherapy",
      "status": "COMPLETED",
      "last_update": "2026-01-08",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04340258",
      "title": "Trial Combining Pembrolizumab and Cesium 131 Brachytherapy With Salvage Surgery in HNSCC",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-06-09",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04349267",
      "title": "Study of BMS-986315 Alone and in Combination With Nivolumab or Cetuximab in Participants With Advanced Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2025-12-17",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04354246",
      "title": "COM902 (A TIGIT Inhibitor) in Subjects With Advanced Malignancies",
      "status": "COMPLETED",
      "last_update": "2026-08-12",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04357873",
      "title": "Efficacy of Immunotherapy Plus a Drug in Patients With Progressive Advanced Mucosal Cancer of Different Locations",
      "status": "COMPLETED",
      "last_update": "2025-02-19",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04369937",
      "title": "HPV-16 Vaccination and Pembrolizumab Plus Cisplatin for \"Intermediate Risk\" HPV-16-associated Head and Neck Squamous Cell Carcinoma",
      "status": "COMPLETED",
      "last_update": "2026-05-13",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04379596",
      "title": "Ph1b/2 Study of the Safety and Efficacy of T-DXd Combinations in Advanced HER2-expressing Gastric Cancer (DESTINY-Gastric03)",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-08-28",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04389177",
      "title": "Pembrolizumab Plus Paclitaxel, Cisplatin Followed by Surgery for Locally Advanced ESCC (KEYSTONE-001)",
      "status": "UNKNOWN",
      "last_update": "2023-04-10",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04398056",
      "title": "Chemotherapy Plus Subsequent Loco-regional Radiotherapy Combined With Toripalimab in the De Novo Metastatic Nasopharyngeal Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2022-07-06",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04398524",
      "title": "A Phase II Study of Cemiplimab and ISA101b in Patients With Recurrent/Metastatic HPV16 Positive OPC",
      "status": "UNKNOWN",
      "last_update": "2024-01-16",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04428151",
      "title": "Lenvatinib (E7080/MK-7902) in Combination With Pembrolizumab (MK-3475) vs. Standard Chemotherapy and Lenvatinib Monotherapy in Participants With Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma That Progressed After Platinum Therapy and Immunotherapy (MK-7902-009/E7080-G000-228/LEAP-009)",
      "status": "COMPLETED",
      "last_update": "2025-12-04",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04430738",
      "title": "Tucatinib Plus Trastuzumab and Oxaliplatin-based Chemotherapy or Pembrolizumab-containing Combinations for HER2+ Gastrointestinal Cancers",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-02-24",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04452214",
      "title": "A Study of the Safety and Tolerance of CAN04 and Pembrolizumab in Combination With and Without Carboplatin and Pemetrexed in Subjects With Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2023-07-14",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04454489",
      "title": "Quad Shot Radiotherapy in Combination With Immune Checkpoint Inhibition",
      "status": "COMPLETED",
      "last_update": "2025-11-19",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04458909",
      "title": "Testing the Addition of an Anti-cancer Immune Therapy Drug (Nivolumab) to the Usual Chemotherapy Treatment (Cisplatin or Carboplatin With Gemcitabine) for Recurrent or Metastatic Nasopharyngeal Cancer",
      "status": "TERMINATED",
      "last_update": "2025-10-03",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04460456",
      "title": "A Study of SBT6050 Alone and in Combination With PD-1 Inhibitors in Subjects With Advanced HER2 Expressing Solid Tumors",
      "status": "UNKNOWN",
      "last_update": "2022-06-30",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04465487",
      "title": "Study of REGN6569 and Cemiplimab in Adult Patients With Advanced Solid Tumor Malignancies",
      "status": "TERMINATED",
      "last_update": "2025-02-24",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04485013",
      "title": "TTX-080 HLA-G Antagonist in Subjects With Advanced Cancers",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-09-11",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04503967",
      "title": "Efficacy and Safety of Anlotinib Hydrochloride Combined With Nivolumab in the Treatment of Gastric and Esophageal Cancer",
      "status": "UNKNOWN",
      "last_update": "2020-08-07",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04510285",
      "title": "A Single-Arm Pilot Study of Adjuvant Pembrolizumab Plus Trastuzumab in HER2+ Esophagogastric Tumors With Persistent Circulating Tumor DNA Following Curative Resection",
      "status": "TERMINATED",
      "last_update": "2023-02-01",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04514484",
      "title": "Testing the Combination of the Anti-cancer Drugs XL184 (Cabozantinib) and Nivolumab in Patients With Advanced Cancer and HIV",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-05-28",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04517214",
      "title": "Comparing Chemotherapy With/Without Toripalimab For Primary Metastatic Nasopharyngeal Carcinoma",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-04-02",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04523883",
      "title": "Concurrent Immunotherapy With Postoperative Radiotherapy in Intermediate/High Risk HNSCC Patients Unfit for Cisplatin: The IMPORT Study (IMPORT)",
      "status": "UNKNOWN",
      "last_update": "2021-04-15",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04541108",
      "title": "Phase 0 Master Protocol for CIVO Intratumoral Microdosing of Anti-Cancer Therapies",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-05-22",
      "phase": "EARLY_PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04555837",
      "title": "Alisertib and Pembrolizumab for the Treatment of Patients With Rb-deficient Head and Neck Squamous Cell Cancer",
      "status": "COMPLETED",
      "last_update": "2025-05-20",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04557020",
      "title": "Adding PD-1 Inhibitor to Neoadjuvant and Adjuvant for NPC",
      "status": "UNKNOWN",
      "last_update": "2024-05-01",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04570839",
      "title": "COM701 in Combination With BMS-986207 and Nivolumab in Subjects With Advanced Solid Tumors.",
      "status": "COMPLETED",
      "last_update": "2024-07-18",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04603248",
      "title": "A Study for Identification of Immune Determinants for Response to Nivolumab in Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma",
      "status": "COMPLETED",
      "last_update": "2026-06-10",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04609566",
      "title": "Brentuximab Vedotin With Pembrolizumab in Metastatic Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2026-07-06",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04624113",
      "title": "Tazemetostat and Pembrolizumab in Patients With Pembrolizumab- or Nivolumab-Resistant, Recurrent or Metastatic Head and Neck Squamous-Cell Carcinoma",
      "status": "TERMINATED",
      "last_update": "2024-02-21",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04625543",
      "title": "Neoadjuvant Immunotherapy to ESCC",
      "status": "WITHDRAWN",
      "last_update": "2022-04-26",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04634825",
      "title": "Enoblituzumab Plus Retifanlimab or Tebotelimab in Head and Neck Cancer",
      "status": "TERMINATED",
      "last_update": "2023-12-20",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04641871",
      "title": "Sym021 in Combination With Either Sym022 or Sym023 or Sym023 and Irinotecan in Patients With Recurrent Advanced Selected Solid Tumor Malignancies",
      "status": "COMPLETED",
      "last_update": "2024-06-26",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04643379",
      "title": "Olaparib in Combination With Pembrolizumab and Carboplatin as First-Line Treatment of Recurrent or Metastatic Head and Neck Squamous-Cell Carcinoma",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-10-22",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04659369",
      "title": "Study of Pharmacokinetic, Safety, Immunogenicity and Efficacy of CMAB819 and Nivolumab in R/M HNSCC",
      "status": "TERMINATED",
      "last_update": "2024-04-09",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT04660929",
      "title": "CAR-macrophages for the Treatment of HER2 Overexpressing Solid Tumors",
      "status": "UNKNOWN",
      "last_update": "2024-12-18",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04670679",
      "title": "A Dose Escalation/Expansion Study of ERAS-601 in Patients With Advanced or Metastatic Solid Tumors",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-03-25",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04682431",
      "title": "A Phase 1a/1b FIH Study of PY159 and in Combination With Pembrolizumab in Subjects With Advanced Solid Tumors",
      "status": "TERMINATED",
      "last_update": "2024-03-22",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04704154",
      "title": "A Trial to Learn Whether Regorafenib in Combination With Nivolumab Can Improve Tumor Responses and How Safe it is for Participants With Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2025-04-18",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04731467",
      "title": "A Study of CM24 in Combination with Nivolumab in Adults with Advanced Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2024-12-27",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04731740",
      "title": "Pembrolizumab and Lenvatinib/Chemotherapy for Poorly Differentiated/Anaplastic Thyroid Cancer",
      "status": "WITHDRAWN",
      "last_update": "2024-03-25",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04736810",
      "title": "A Study of Penpulimab Combination Therapy in Patients With Advanced Nasopharyngeal Carcinoma",
      "status": "COMPLETED",
      "last_update": "2025-03-07",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04757363",
      "title": "A Study of Nivolumab Combined With FOLFOX and Regorafenib in People Who Have HER2-Negative Esophagogastric Cancer",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-03-04",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04767295",
      "title": "A Study of Camrelizumab Combined With Chemotherapy as Neoadjuvant Therapy in Adcanced Esophageal Squamous Cell Carcinoma (ESCC)",
      "status": "UNKNOWN",
      "last_update": "2021-02-23",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04769076",
      "title": "The Paclitaxel (Albumin-bound) Combined With Cisplatin, PD-1 Inhibitors and IMRT in the Treatment of Nasopharyngeal Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2021-02-25",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04785820",
      "title": "A Study of Lomvastomig (RO7121661) and Tobemstomig (RO7247669) Compared With Nivolumab in Participants With Advanced or Metastatic Squamous Cell Carcinoma of the Esophagus",
      "status": "COMPLETED",
      "last_update": "2026-03-27",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04795713",
      "title": "Study of MT-6402 in Subjects With Advanced Solid Cancer That Expresses PD-L1",
      "status": "TERMINATED",
      "last_update": "2024-11-04",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04811027",
      "title": "Combination Study With Eftilagimod Alpha (a Soluble LAG-3 Fusion Protein) and Pembrolizumab in Patients With Recurrent or Metastatic HNSCC",
      "status": "COMPLETED",
      "last_update": "2025-12-11",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04825990",
      "title": "Pembrolizumab and Olaparib in Recurrent/Metastatic, Platinum Resistant Nasopharyngeal Cancer",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-06-01",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04830592",
      "title": "A Study of NG-641 and Pembrolizumab in Squamous Cell Carcinoma of the Head and Neck",
      "status": "COMPLETED",
      "last_update": "2025-03-24",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04831320",
      "title": "Nab-Paclitaxel in Combination With Nivolumab to Treat Recurrent or Metastatic Head and Neck Squamous-Cell Carcinoma That Progressed on a PD-1 or PD-L1 Inhibitor",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-07-06",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04831450",
      "title": "Phase 2 Trial of Maintenance Cemiplimab for Head and Neck Squamous Cell Carcinoma (HNSCC)",
      "status": "WITHDRAWN",
      "last_update": "2022-08-04",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04848116",
      "title": "Neoadjuvant Targeting of Myeloid Cell Populations in Combination With Nivolumab in Head & Neck Ca",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-05-14",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04862455",
      "title": "NBTXR3, Radiation Therapy, and Pembrolizumab for the Treatment of Recurrent or Metastatic Head and Neck Squamous Cell Cancer",
      "status": "TERMINATED",
      "last_update": "2026-01-23",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04862650",
      "title": "Cemiplimab, Low-Dose Paclitaxel and Carboplatin for the Treatment of Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-06-25",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04872582",
      "title": "Efficacy and Safety of Sintilimab Plus Bevacizumab in Metastatic Nasopharyngeal Carcinoma After Failure of Platinum-based Chemotherapy: An Open-label Phase II Study",
      "status": "UNKNOWN",
      "last_update": "2023-02-23",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04879849",
      "title": "A Study of TAK-676 With Pembrolizumab After Radiation Therapy to Treat a Number of Cancers",
      "status": "COMPLETED",
      "last_update": "2025-09-04",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT04891718",
      "title": "CIVO Intratumoural Microdosing of Anti-Cancer Therapies in Australia",
      "status": "WITHDRAWN",
      "last_update": "2022-07-08",
      "phase": "EARLY_PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04892043",
      "title": "Study of SQZ-AAC-HPV in Patients With HPV16+ Recurrent, Locally Advanced or Metastatic Solid Tumors",
      "status": "TERMINATED",
      "last_update": "2024-02-23",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04895735",
      "title": "MC200708 Pemetrexed and Pembrolizumab for the Treatment of Recurrent and/or Metastatic Salivary Gland Cancer",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-06-04",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04913337",
      "title": "Study of NGM707 As Monotherapy and in Combination with Pembrolizumab in Advanced or Metastatic Solid Tumor Malignancies",
      "status": "UNKNOWN",
      "last_update": "2024-10-02",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04916002",
      "title": "A Trial To Find Out If Vidutolimod Together With Cemiplimab Is Safe And If It Works In Adult Participants With Advanced Cancer Or Metastatic Cancer",
      "status": "TERMINATED",
      "last_update": "2026-06-09",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04921995",
      "title": "Immunotherapy and Chemotherapy in Unresectable Recurrent Loco-regionally Advanced Nasopharyngeal Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2022-04-04",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04925284",
      "title": "Study of XB002 in Subjects With Solid Tumors (JEWEL-101)",
      "status": "COMPLETED",
      "last_update": "2025-04-04",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04936841",
      "title": "Bempegaldesleukin (NKTR-214) With Radiation and Anti-PD-1 Immunotherapy for Head and Neck Squamous Cell Carcinoma",
      "status": "TERMINATED",
      "last_update": "2024-04-04",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04943445",
      "title": "Study of a Pembrolizumab-based Organ Preservation Strategy for Locally Advanced Larynx Cancers",
      "status": "COMPLETED",
      "last_update": "2026-08-27",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04943900",
      "title": "A Study of BMS-986416 With and Without Nivolumab in Select Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2025-04-09",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04947241",
      "title": "Toripalimab Combined With Gemcitabine and Cisplatin Treating Resectable Locally Advanced HNSCC",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-09-09",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04969861",
      "title": "BEMPEG With Pembrolizumab vs Pembrolizumab Alone in Patients With Metastatic or Recurrent HNSCC (PROPEL-36)",
      "status": "TERMINATED",
      "last_update": "2023-01-12",
      "phase": "PHASE2/PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04978012",
      "title": "Fluzoparib and Camrelizumab in Treating Patients With R/M NPC That Progressed After First-line Chemotherapy",
      "status": "UNKNOWN",
      "last_update": "2022-06-07",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04984733",
      "title": "Temozolomide + Nivolumab in MGMT Methylated Oesophagogastric Cancer",
      "status": "COMPLETED",
      "last_update": "2026-05-18",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04992988",
      "title": "Concurrent Chemoradiotherapy With Toripalimab for Local-regional Recurrent Nasopharyngeal Carcinoma: a Prospective, Single-arm, Phase II Trial",
      "status": "UNKNOWN",
      "last_update": "2021-08-20",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04995120",
      "title": "Induction Chemotherapy and Toripalimab for Larynx Preservation in Resectable Laryngeal/Hypopharyngeal Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2022-01-18",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04999202",
      "title": "A Study to Learn How Safe the Study Drug BAY 2416964 (AhR Inhibitor) in Combination With the Treatment Pembrolizumab is, How This Combination Affects the Body, the Maximum Amount That Can be Given, How it Moves Into, Through and Out of the Body and Its Action Against Advanced Solid Cancers in Adults",
      "status": "TERMINATED",
      "last_update": "2025-02-10",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05027204",
      "title": "A Study of Docetaxel for Injection (Albumin-bound) in Combination With Nivolumab in Patients With Head and Neck (SCCHN)",
      "status": "UNKNOWN",
      "last_update": "2022-10-13",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05060432",
      "title": "Study of EOS-448 With Standard of Care and/or Investigational Therapies in Participants With Advanced Solid Tumors",
      "status": "UNKNOWN",
      "last_update": "2024-06-21",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05061537",
      "title": "Study of PF-07263689 in Participants With Selected Advanced Solid Tumors",
      "status": "TERMINATED",
      "last_update": "2024-04-12",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05069935",
      "title": "FT538 in Combination With Monoclonal Antibodies in Advanced Solid Tumors",
      "status": "TERMINATED",
      "last_update": "2023-09-21",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05077709",
      "title": "IO102-IO103 in Combination With Pembrolizumab as First-line Treatment for Patients With Metastatic NSCLC, SCCHN, or mUBC",
      "status": "COMPLETED",
      "last_update": "2026-04-08",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05094804",
      "title": "A Study of OR2805, a Monoclonal Antibody Targeting CD163, Alone and in Combination With Anticancer Agents",
      "status": "UNKNOWN",
      "last_update": "2023-11-02",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05119296",
      "title": "Phase II Trial of Pembrolizumab in Metastatic or Locally Advanced Anaplastic/Undifferentiated Thyroid Cancer",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-09-09",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05145907",
      "title": "Study to Evaluate Safety and Efficacy of TJ107 Combine With PD-1 in Patients With Solid Tumors",
      "status": "UNKNOWN",
      "last_update": "2024-04-15",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05201859",
      "title": "Adjuvant Sintilimab Plus Capecitabine in Nasopharyngeal Carcinoma",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-05-07",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05213312",
      "title": "Study of Neoadjuvant Nivolumab or Placebo Plus Chemotherapy Followed by Surgery and Adjuvant Treatment in Subjects With Resectable ESCC",
      "status": "UNKNOWN",
      "last_update": "2022-06-15",
      "phase": "PHASE2/PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05213884",
      "title": "The Efficacy of Induction and Adjuvant Camrelizumab Combined With Chemoradiation for LA-HNSCC",
      "status": "COMPLETED",
      "last_update": "2026-04-24",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05215574",
      "title": "Study of NGM831 as Monotherapy and in Combination With Pembrolizumab or Pembrolizumab and NGM438 in Advanced or Metastatic Solid Tumors",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2024-10-10",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05220748",
      "title": "RM-1995 Photoimmunotherapy, as Monotherapy or Combined With Pembrolizumab, in Patients With Advanced CuSCC and HNSCC",
      "status": "WITHDRAWN",
      "last_update": "2023-04-19",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05229315",
      "title": "PD-1 Combined With Intensity Modulated Radiation Therapy in the Treatment of Intermediate-risk Nasopharyngeal Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2023-04-13",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05229614",
      "title": "Immunotherapy and Carbon Ion Radiotherapy In Solid Cancers With Stable Disease",
      "status": "UNKNOWN",
      "last_update": "2024-08-21",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05234606",
      "title": "A Safety and Preliminary Efficacy Study of SBT6290 Alone and in Combination With PD-(L)1 Inhibitors in Select Advanced Solid Tumors",
      "status": "WITHDRAWN",
      "last_update": "2022-04-12",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05249426",
      "title": "A Study to Test Whether Different Combinations of BI 765063, Ezabenlimab, Chemotherapy, Cetuximab, and BI 836880 Help People With Head and Neck Cancer or Liver Cancer",
      "status": "COMPLETED",
      "last_update": "2026-07-07",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05259696",
      "title": "Glycan Mediated Immune Regulation With a Bi-Sialidase Fusion Protein (GLIMMER-01)",
      "status": "COMPLETED",
      "last_update": "2025-08-20",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05265013",
      "title": "ASP-1929 Photoimmunotherapy Combined With Pembrolizumab in Patients With Recurrent Head and Neck Cancer, With or Without Metastases",
      "status": "TERMINATED",
      "last_update": "2024-11-04",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05280457",
      "title": "HPV 16-positive and/or HPV 18-positive Recurrent and/or For Patients With Metastatic Head and Neck Cancer to Evaluate GX-188E DNA Vaccination, GX-I7 and Nivolumab Combination Therapy",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-06-11",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05287113",
      "title": "Study of Retinfanlimab in Combination With INCAGN02385 and INCAGN02390 as First-Line Treatment in Participants With PD-L1-Positive (CPS \u2265 1) Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-03-27",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05311618",
      "title": "Study of NGM438 as Monotherapy and in Combination With Pembrolizumab in Advanced or Metastatic Solid Tumors",
      "status": "UNKNOWN",
      "last_update": "2024-04-01",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05327270",
      "title": "Non-randomized, Open-label Study of Intralesional Nivolumab for High Risk Oral Premalignant Lesions",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-06-12",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05366166",
      "title": "Pembrolizumab Plus Olaparib in LA-HNSCC",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-01-28",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05393635",
      "title": "ITIL-168 in Advanced Solid Tumors",
      "status": "WITHDRAWN",
      "last_update": "2022-12-20",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05395052",
      "title": "FT536 Monotherapy and in Combination With Monoclonal Antibodies in Advanced Solid Tumors",
      "status": "TERMINATED",
      "last_update": "2023-09-21",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05424432",
      "title": "Short Course Neoadjuvant Chemo-radiotherapy Plus Toripalimab for Locally Advanced Resectble Squamous Cell Carcinoma of Esophagus",
      "status": "UNKNOWN",
      "last_update": "2022-06-27",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05429866",
      "title": "Immunological Variables Associated to ICI Toxicity in Cancer Patients",
      "status": "UNKNOWN",
      "last_update": "2023-03-08",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05431764",
      "title": "Whole-target Consolidation Therapy Under Systemic Therapy for Oligometastatic Nasopharyngeal Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2022-06-24",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05438420",
      "title": "Oral Axl/Mer/CSF1R Selective Tyrosine Kinase Inhibitor Q702 in Combination With Pembrolizumab in Patients With Selected Advanced Solid Tumors",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-02-24",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05472506",
      "title": "Oral AHR Antagonist in Combination With Nivolumab in Patients With PD-1 Resistant Metastatic or Recurrent Head and Neck Cancer",
      "status": "WITHDRAWN",
      "last_update": "2024-03-15",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05480384",
      "title": "Adjuvant Trastuzumab Deruxtecan (Enhertu) & Nivolumab For Patients Who Are Disease Free After Completion of Trimodality Treatment For HER-2+ Cancers of Esophagus & Gastroesophageal Junction",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-04-21",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT05490719",
      "title": "A Phase II Study of CRT Combined With QL1706 in ESCC Patients",
      "status": "UNKNOWN",
      "last_update": "2024-05-21",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT05491616",
      "title": "Nivolumab During Active Surveillance After Neoadjuvant Chemoradiation for Esophageal Cancer: SANO-3 Study",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-02-13",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05523323",
      "title": "A Study of Pembrolizumab (MK-3475) With or Without Lenvatinib (E7080/MK-7902) as First Line (1L) Intervention in a Programmed Cell Death-ligand 1 (PD-L1) Selected Population With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma (R/M HNSCC) (MK-7902-010/LEAP-010)-China Extension",
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      "last_update": "2026-03-13",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05535023",
      "title": "Phase 2 Study of Neoadjuvant SAR444245 Plus Cemiplimab in HPV Related Oropharynx Squamous Cell Carcinoma",
      "status": "WITHDRAWN",
      "last_update": "2023-09-13",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05563480",
      "title": "TQB2618 Injection Combined With Penpulimab Injection in the Treatment of Patients With Recurrent/Metastatic Nasopharyngeal Carcinoma",
      "status": "COMPLETED",
      "last_update": "2026-04-07",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05576077",
      "title": "A Study of TBio-4101 (TIL) and Pembrolizumab in Patients With Advanced Solid Tumors",
      "status": "TERMINATED",
      "last_update": "2025-03-10",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT05577182",
      "title": "Study of INCA32459 a LAG-3 and PD-1 Bispecific Antibody in Participants With Select Advanced Malignancies",
      "status": "COMPLETED",
      "last_update": "2025-11-03",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT05581004",
      "title": "A Study to Evaluate the Safety, Pharmacokinetics, and Activity of Enzelkitug as a Single Agent and in Combination With Checkpoint Inhibitor in Participants With Locally Advanced or Metastatic Solid Tumors",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-08-06",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT05585034",
      "title": "Phase 1, First-in-human, Dose-finding and Expansion Study to Evaluate XmAb\u00ae808 in Combination With Pembrolizumab in Advanced Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2025-08-07",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05597839",
      "title": "Study of DF9001 in Patients With Advanced Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2025-10-29",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05620134",
      "title": "Study of JK08 in Patients with Unresectable Locally Advanced or Metastatic Cancer",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2024-10-15",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05621707",
      "title": "Chemoradiotherapy Following Immunotherapy Plus Chemotherapy for Locally-advanced Esophageal Squamous Cell Cancer (RICE)",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-02-02",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05655663",
      "title": "Evaluation of Vascular Toxicity of Immune Checkpoint Inhibitors in Patients Head and Neck or Lung Cancer",
      "status": "UNKNOWN",
      "last_update": "2022-12-19",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05659186",
      "title": "PD-1 Inhibitor and Anlotinib Combined With Multimodal Radiotherapy in Recurrent or Metastatic Anaplastic Thyroid Cancer",
      "status": "UNKNOWN",
      "last_update": "2022-12-21",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05704985",
      "title": "Evaluating Safety and Biomarkers Using DK210 (EGFR) for Locally Advanced or Metastatic EGFR+ Tumors",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-05-29",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05708950",
      "title": "A Clinical Trial of KVA12123 [TBS-2025] Treatment Alone and in Combination With Pembrolizumab In Advanced Solid Tumors (VISTA-101)",
      "status": "COMPLETED",
      "last_update": "2026-06-18",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05724329",
      "title": "Neoadjuvant Tislelizumab in Combination With Dasatinib and Quercetin in Resectable HNSCC (COIS-01)",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2024-09-19",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05724355",
      "title": "CDK4/6 Inhibitor Plus Camrelizumab for PD-1 Inhibitor Refractory R/M NPC",
      "status": "UNKNOWN",
      "last_update": "2023-02-13",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05732662",
      "title": "SBRT Combined With AK104 to Treatment Relapsed or Metastatic ESCC",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2023-02-17",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05743270",
      "title": "Study of RP3 in Combination With Nivolumab and Other Therapy in Patients With Locoregionally Advanced or Recurrent SCCHN",
      "status": "WITHDRAWN",
      "last_update": "2025-03-11",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05802290",
      "title": "NIVolumab in Subjects With Recurrent or Metastatic Platinum-refrACTORy SCCHN",
      "status": "COMPLETED",
      "last_update": "2023-04-06",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05821751",
      "title": "The Effect of Prebiotic Inulin on Patients Affected by R/M HNSCC Treated With Immune Checkpoint Inhibitors",
      "status": "UNKNOWN",
      "last_update": "2023-04-20",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05829057",
      "title": "The IIT Study of Evaluation of P-IL-2 Single Agent and With Anti-PD-1",
      "status": "UNKNOWN",
      "last_update": "2024-02-13",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05858736",
      "title": "Safety, PK and Efficacy of AI-061 in Advanced Solid Tumors",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-04-09",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05864144",
      "title": "A Study of SNS-101 (Anti VISTA) Monotherapy and in Combination With Cemiplimab in Patients With Advanced Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2026-09-02",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05878288",
      "title": "Deep sequencIng in Cutaneous Squamous CEll caRciNomas",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2024-11-21",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05898828",
      "title": "Phase I/II Evaluation of a Cancer Lysate Vaccine and Montanide(R) ISA-51 VG With Entinostat and Nivolumab as Adjuvant Therapy Following Chemoradiation Therapy With or Without Surgery for Locally Advanced Esophageal Cancer",
      "status": "WITHDRAWN",
      "last_update": "2024-08-05",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05904496",
      "title": "A Study of BGB-30813 Alone or in Combination With Tislelizumab in Participants With Advanced or Metastatic Solid Tumors",
      "status": "TERMINATED",
      "last_update": "2025-09-16",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05929664",
      "title": "Cemiplimab Plus Fianlimab for the Treatment of Locally Advanced Head and Neck Basal Cell Carcinoma Before Surgery",
      "status": "SUSPENDED",
      "last_update": "2026-06-10",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05961111",
      "title": "A Clinical Study on Oncolytic Virus Injection (R130 OV) for the Treatment of Advanced Solid Tumors",
      "status": "UNKNOWN",
      "last_update": "2023-07-27",
      "phase": "EARLY_PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05964101",
      "title": "Nivolumab Combined With Chemotherapy in the Treatment of Primary Tracheal Squamous Cell Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2024-05-21",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05980598",
      "title": "TransCon (TC) TLR7/8 Agonist, TC IL-2 \u03b2/\u03b3, Pembrolizumab Prior to Surgery for Advanced Head and Neck Squamous Cell Carcinoma",
      "status": "TERMINATED",
      "last_update": "2025-08-01",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06022757",
      "title": "Study of XNW5004 Tablet in Combination With KEYTRUDA\u00ae (Pembrolizumab) in Subjects With Advanced Solid Tumors Who Failed Standard Treatments (KEYNOTE F19)",
      "status": "TERMINATED",
      "last_update": "2026-07-23",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06034860",
      "title": "Study of MT-8421 as Monotherapy and in Combination With Nivolumab in Patients With Selected Advanced Solid Cancer Types",
      "status": "TERMINATED",
      "last_update": "2024-11-01",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06046482",
      "title": "Phase II Trial of Magrolimab and Cetuximab With Pembrolizumab or Docetaxel for Recurrent/Metastatic Head Neck Squamous Cell Carcinoma",
      "status": "TERMINATED",
      "last_update": "2025-10-22",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06052852",
      "title": "Study of BDC-3042 as Single Agent and in Combination With Cemiplimab in Patients With Advanced Malignancies",
      "status": "TERMINATED",
      "last_update": "2025-11-17",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06078657",
      "title": "IBI110 Combined With Sintilimab in Second-line Advanced or Metastatic Esophageal Squamous Cell Carcinoma(ESCC)",
      "status": "UNKNOWN",
      "last_update": "2023-10-12",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06081582",
      "title": "Toripalimab in Combined With Cetuximab\uff0cChemotherapy for Conversion Therapy of Locally Nonresectable OCSCC",
      "status": "UNKNOWN",
      "last_update": "2023-10-13",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06082167",
      "title": "Study of Zanzalintinib (XL092) + Pembrolizumab vs Pembrolizumab in Subjects With PD-L1 Positive Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-08-17",
      "phase": "PHASE2/PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06095167",
      "title": "Induction Chemotherapy and Immunotherapy Combined Radiotherapy With or Without Concurrent Chemotherapy for Stage III-IVa NPC",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2023-10-23",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06156878",
      "title": "PD-1 Inhibitor Plus Anti-EGFR Therapy And Radiotherapy in Locally Advanced NPC Resistant to Induction Chemotherapy",
      "status": "UNKNOWN",
      "last_update": "2023-12-05",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06184841",
      "title": "HAIC Combined Sintilimab for Liver Metastasis From Esophageal Squamous Cell Carcinoma",
      "status": "COMPLETED",
      "last_update": "2023-12-28",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06259721",
      "title": "Anti-PD1 Monoclonal Antibody Combined With Nimotuzumab and Capecitabine in Patients With First-line Platinum-resistant Recurrent/Metastatic Nasopharyngeal Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2024-03-07",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06285097",
      "title": "A Study of PF-07820435 as a Single Agent and in Combination in Participants With Advanced Solid Tumors",
      "status": "TERMINATED",
      "last_update": "2025-09-17",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06308913",
      "title": "Pembrolizumab, INCB081776, and Radiation Therapy for Head and Neck Squamous Cell Carcinoma",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-05-26",
      "phase": "EARLY_PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06357858",
      "title": "ASTX727 and Nivolumab in Squamous Cell Carcinoma of the Head and Neck",
      "status": "WITHDRAWN",
      "last_update": "2024-07-03",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06446570",
      "title": "Phase II Study of Durvalumab(MEDI4736) + Tremelimumab in Pulmonary Sarcomatoid Carcinoma",
      "status": "COMPLETED",
      "last_update": "2024-06-06",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06469060",
      "title": "Neoadjuvant Immunochemotherapy for Adenocarcinoma of the Esophagogastric Junction",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2024-07-01",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06513884",
      "title": "A Study of HB-202/HB-201 With Pembrolizumab in Patients With HPV16+ Recurrent/Metastatic Oropharyngeal Cancer",
      "status": "WITHDRAWN",
      "last_update": "2025-06-22",
      "phase": "PHASE2/PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06544655",
      "title": "A Study of BMS-986484 Alone and Combination Therapy in Participants With Advanced Solid Tumors",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-04-17",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06557889",
      "title": "Reduction in the Number of Chemotherapy Cycles in Combination With Pembrolizumab in First-line Treatment of PD-L1-positive Recurrent or Metastatic Head and Neck Squamous Cell Carcinomas",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-09-11",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06568172",
      "title": "Testing the Addition of an Immunotherapy Drug, Cemiplimab (REGN2810), Plus Surgery to the Usual Surgery Alone for Treating Advanced Skin Cancer",
      "status": "SUSPENDED",
      "last_update": "2026-09-01",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06676293",
      "title": "Compassionate Use of Asparaginase and Pembrolizumab Combination Theaapy for Nasopharyngeal Carcinoma",
      "status": "COMPLETED",
      "last_update": "2024-11-07",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06682806",
      "title": "A Study of PRT3789 in Combination With Pembrolizumab in Patients With Advanced or Metastatic Solid Tumors With a SMARCA4 Mutation",
      "status": "TERMINATED",
      "last_update": "2026-02-02",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06703047",
      "title": "Tislelizumab Combined with Chemotherapy and All Trans Retinoic Acid for Locally Advanced or Metastatic Esophageal Squamous Cell Carcinoma",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2024-11-25",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06793761",
      "title": "A Phase II Study to Evaluate the Efficacy and Safety of Salvage Preoperative PD-1 Inhibitor Combined with Chemotherapy Neoadjuvant Therapy in Recurrent and Metastatic LPSCC/HPSCC",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2025-01-27",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06806852",
      "title": "A Study to Test Whether Treatment With BI 770371 in Combination With Pembrolizumab With or Without Cetuximab Helps People With Head and Neck Cancer Compared With Pembrolizumab Alone",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-09-02",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06814067",
      "title": "Phase II Multi-centered Study of Perioperative Ivonescimab Versus Pembrolizumab Combined with Standard of Care (SOC) in Patients with Resectable, Locally Advanced Head and Neck Squamous Cell Carcinoma",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2025-02-07",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06855212",
      "title": "Phase II Study of Neoadjuvant Cetuximab and Cemiplimab in Patients Undergoing Surgery for HNSCC",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-05-20",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06894771",
      "title": "A Study of MK-4700 Alone or With Pembrolizumab in Participants With Advanced or Metastatic Solid Tumors (MK-4700-001)",
      "status": "COMPLETED",
      "last_update": "2026-03-16",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06900218",
      "title": "PD-1 Antibody Sintilimab Combined With Capecitabine as Adjuvant Therapy for High-Risk Nasopharyngeal Carcinoma",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2025-04-02",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06919666",
      "title": "NT219 Combined With Standard of Care Biologic Therapy in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-07-02",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06957938",
      "title": "Comparing Neoadjuvant Chemotherapy Combined With PD-1 Inhibitor Versus Neoadjuvant Chemotherapy in Locally Advanced Laryngeal and Hypopharyngeal Carcinoma",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2025-05-08",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07010393",
      "title": "Genotype-Driven Neoadjuvant Therapy for Locally Advanced Thyroid Cancer: A Real-World Cohort Study",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2025-06-08",
      "phase": "PHASE4",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07016737",
      "title": "Immunochemotherapy \u00b1 Salvage Chemoradiation for Local Recurrence of Esophageal Squamous Cell Carcinoma After Definitive Chemoradiotherapy",
      "status": "ENROLLING_BY_INVITATION",
      "last_update": "2025-06-12",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07049185",
      "title": "QL1706 Plus Celecoxib in Advanced Esophageal Squamous Cell Carcinoma",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2025-07-03",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07110558",
      "title": "Radiotherapy Omitting Prophylactic Neck Irradiation With Neoadjuvant and Adjuvant Toripalimab in Nasopharyngeal Carcinoma",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2025-08-07",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07196384",
      "title": "Optical PD-1 and PD-L1 Imaging in Locally Advanced Esophageal Cancer Using Durvalumab-680LT and Nivolumab-800CW",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2025-11-21",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07216833",
      "title": "Decitabine and Nivolumab in Participants With Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck",
      "status": "WITHDRAWN",
      "last_update": "2026-06-22",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07244978",
      "title": "Neoadjuvant Ivonescimab\uff08AK112\uff09 Combined With Chemotherapy in Patients With Resectable Esophageal Squamous Cell Carcinoma",
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      "title": "A Study of SYS6010, Enlonstobart, and Chemotherapy for First-Line Treatment of Esophageal Squamous Cell Carcinoma.",
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      "nct": "NCT07320963",
      "title": "Chidamide in Combination With Toripalimab and Anlotinib in Recurrent/Metastatic Nasopharyngeal Carcinoma.",
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      "nct": "NCT07346196",
      "title": "A Trial of Locoregionally Advanced Squamous Cell Carcinoma of The Head and Neck",
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      "nct": "NCT07379424",
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      "nct": "NCT07509099",
      "title": "Cetuximab Combined With Pembrolizumab or Finotonlimab and Chemotherapy in R/M HNSCC",
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      "title": "Evaluation of the Efficacy and Safety of Nivolumab Neoadjuvant Treatment of Patients With Locally Advanced Oral Squamous Cell Carcinoma",
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      "nct": "NCT07529873",
      "title": "Phase II Study of Ficerafusp Alfa in Combination With Nivolumab in Patients With Platinum-refractory Head and Neck Squamous Cell Carcinoma",
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      "title": "Low Dose, Reduced Frequency Nivolumab for the Treatment of Unresectable or Metastatic Cancer, AFFORD IO Trial",
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     {
      "nct": "NCT07618624",
      "title": "BRIDGE Study: Neoadjuvant Finotonlimab, Cetuximab, and Docetaxel in Resectable Recurrent HNSCC After Immunotherapy Progression",
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      "nct": "NCT07623642",
      "title": "A Phase II Study of GV20-0251 in Combination With Anti-PD-1 Monoclonal Antibodies in Patients With Unresectable, Locally Advanced, or Metastatic Solid Tumors.",
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     {
      "nct": "NCT07650266",
      "title": "A Study of Cemiplimab and Fianlimab in People With Nasopharyngeal Carcinoma",
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      "nct": "NCT07659678",
      "title": "CCR2 PET Imaging Head and Neck Squamous Cell Carcinoma",
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     {
      "nct": "NCT07662720",
      "title": "A Phase II Trial for MOR Antagonism With Axelopran to Enhance Immunotherapy in Head and Neck Cancer",
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      "nct": "NCT07744126",
      "title": "A Study to Assess Adverse Events, Change in Disease Activity and Optimal Dose of Intravenous (IV) Telisotuzumab Adizutecan With IV Pembrolizumab for First-Line Treatment of Adult Participants With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma",
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     {
      "nct": "NCT07770100",
      "title": "Concurrent Immunotherapy and Systemic Therapy With Stereotactic Body Radiation Therapy (SBRT) for Stage IV Cancers (COINSSS IV)",
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     {
      "nct": "NCT07773987",
      "title": "Immunotherapy and Nodal-Sparing Irradiation for T-Cell Induction and Unmasking of Tumor Antigenicity in the Microenvironment for Head and Neck Cancer",
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      "last_update": "2026-08-19",
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     {
      "nct": "NCT07776340",
      "title": "Induction PD-1 Inhibitor and Chemotherapy Followed by Chemoradiotherapy in Unresectable or Inoperable HPV-negative LA-HNSCC",
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      "last_update": "2026-08-20",
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     {
      "nct": "NCT07797881",
      "title": "A Study of BL-B01D1 With or Without PD-1 Monoclonal Antibody in Patients With High-Risk Locally Advanced Nasopharyngeal Carcinoma",
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      "last_update": "2026-09-01",
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     {
      "nct": "NCT07807345",
      "title": "Phase 1 Study of STRO-006 in Adults With Refractory Solid Tumors That Are Recurrent or Metastatic",
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       "nct": "NCT06161545",
       "title": "Pembrolizumab + N-803 Alone or in Combination With PD-L1 t-haNK Cells for Resectable Head and Neck Squamous Cell Carcinoma",
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       "last_update": "2026-08-24",
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      {
       "nct": "NCT07410676",
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      {
       "nct": "NCT02757391",
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      {
       "nct": "NCT03435640",
       "title": "REVEAL Study of NKTR-262 in Combination With NKTR-214 and Nivolumab in Patients With Locally Advanced / Metastatic Solid Tumor Malignancies",
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      {
       "nct": "NCT03578406",
       "title": "HPV-E6-Specific Anti-PD1 TCR-T Cells in the Treatment of HPV-Positive NHSCC or Cervical Cancer",
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      {
       "nct": "NCT03645928",
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       "phase": "PHASE2",
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      {
       "nct": "NCT03706326",
       "title": "CAR T and PD-1 Knockout Engineered T Cells for Esophageal Cancer",
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      {
       "nct": "NCT03970382",
       "title": "A Study of Gene Edited Autologous Neoantigen Targeted TCR T Cells With or Without Anti-PD-1 in Patients With Solid Tumors",
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      {
       "nct": "NCT04139057",
       "title": "EBV-Specific Anti-PD1 TCR-T Cells in the Treatment of EBV-Positive NHSCC",
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      {
       "nct": "NCT04936841",
       "title": "Bempegaldesleukin (NKTR-214) With Radiation and Anti-PD-1 Immunotherapy for Head and Neck Squamous Cell Carcinoma",
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      "title": "Cetuximab After Immunotherapy for the Treatment of Head and Neck Squamous Cell Cancer",
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      "nct": "NCT04415853",
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     {
      "nct": "NCT04429542",
      "title": "Study of Safety and Tolerability of BCA101 Monotherapy and in Combination Therapy in Patients With EGFR-driven Advanced Solid Tumors",
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      "nct": "NCT04511078",
      "title": "Phase II Panitumumab-IRDye800 in Head & Neck Cancer",
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      "nct": "NCT04722523",
      "title": "A Study of Cemiplimab With Chemotherapy and Immunotherapy in People With Head and Neck Cancer",
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      "nct": "NCT04892173",
      "title": "JNJ-90301900 (NBTXR3) Activated by Radiotherapy With or Without Cetuximab in LA-HNSCC",
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      "nct": "NCT04930432",
      "title": "Study of MCLA-129, a Human Bispecific EGFR and cMet Antibody, in Patients With Advanced NSCLC and Other Solid Tumors",
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     {
      "nct": "NCT05107674",
      "title": "A Study of NX-1607 in Adults With Advanced Malignancies",
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      "nct": "NCT05183048",
      "title": "Comparison of 89Zr Panitumumab and (18)F-Fluorodeoxyglucose to Identify Head and Neck Squamous Cell Carcinoma",
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      "phase": "EARLY_PHASE1",
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      "nct": "NCT05260671",
      "title": "Penpulimab in Combination With Cetuximab as First-line Treatment in R/M SCCHN",
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      "last_update": "2023-10-18",
      "phase": "PHASE2",
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      "nct": "NCT05332002",
      "title": "sFOLFOXIRI in Advanced Gastroesophageal Cancer, (SAGE)",
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      "last_update": "2026-01-07",
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      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT05717790",
      "title": "Concurrent and Adjuvant Nimotuzumab Combined With Induction Chemotherapy Plus Chemoradiation in Nasopharyngeal Carcinoma",
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      "last_update": "2023-02-08",
      "phase": "NA",
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     {
      "nct": "NCT05747625",
      "title": "(89Zr Panitumumab) With PET/CT for Diagnosing Metastases in Patients With Head and Neck Squamous Cell Carcinoma",
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      "last_update": "2026-05-08",
      "phase": "PHASE1",
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     {
      "nct": "NCT05785741",
      "title": "A Study of DB-1310 in Advanced/Metastatic Solid Tumors",
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      "last_update": "2026-04-06",
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      "nct": "NCT05786924",
      "title": "Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies",
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     {
      "nct": "NCT05901545",
      "title": "Evaluating 111In Panitumumab for Nodal Staging in Head and Neck Cancer",
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      "last_update": "2026-03-05",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT05910827",
      "title": "A Phase Ib/II Study of an Anti-HER3 Antibody, HMBD-001, With Cetuximab +/- Docetaxel in Advanced Squamous Cell Cancers",
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      "last_update": "2026-05-27",
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      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT05945875",
      "title": "Evaluating the Use of Dual Imaging Techniques for Detection of Disease in Patients With Head and Neck Cancer",
      "status": "RECRUITING",
      "last_update": "2025-10-03",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06047379",
      "title": "Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis",
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      "last_update": "2026-07-16",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06084481",
      "title": "Study to Assess Adverse Events and Change in Disease Activity in Adult Participants With Select Advanced Solid Tumor Indications Receiving Intravenous (IV) ABBV-400",
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      "last_update": "2026-08-24",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06239220",
      "title": "PD-L1 t-haNK, NAI IL-15sa and Cetuximab for Recurrent, Metastatic HNSCC",
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      "last_update": "2026-08-18",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06448026",
      "title": "Cemiplimab and Cetuximab Prior Salvage Surgery in Patients With Recurrent Oral Cavity and HPV-negative Oropharyngeal Squamous Cell Carcinoma",
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      "last_update": "2026-07-30",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06589804",
      "title": "Testing the Addition of Anti-Cancer Drug, Cetuximab, to Standard of Care Treatment (Pembrolizumab) for Returning or Spreading Head and Neck Cancer After Previous Treatment",
      "status": "RECRUITING",
      "last_update": "2026-09-08",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06682793",
      "title": "A Study to Evaluate the Safety and Efficacy of A2B395, an Allogeneic Logic-gated CAR T, in Participants With Solid Tumors That Express EGFR and Have Lost HLA-A*02 Expression",
      "status": "RECRUITING",
      "last_update": "2025-09-09",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06699212",
      "title": "A Study of ASP-1929 Photoimmunotherapy in Combination With Pembrolizumab in First-line Treatment of Locoregional Recurrent Squamous Cell Carcinoma of the Head and Neck With No Distant Metastases",
      "status": "RECRUITING",
      "last_update": "2025-10-15",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06715839",
      "title": "Target-specific immunoPET Imaging of Digestive System Carcinoma",
      "status": "RECRUITING",
      "last_update": "2025-12-31",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06760819",
      "title": "A Study to Learn More About How Well Treatment With Sevabertinib (BAY 2927088) Tablets Works and How Safe it is in Participants Who Have a Solid Tumor With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)",
      "status": "RECRUITING",
      "last_update": "2026-09-03",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06788990",
      "title": "FORTIFI-HN01: A Study of Ficerafusp Alfa (BCA101) or Placebo in Combination With Pembrolizumab in First-Line PD-L1-pos, R or M HNSCC",
      "status": "RECRUITING",
      "last_update": "2026-07-17",
      "phase": "PHASE2/PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06802835",
      "title": "EGFR Antibody Combined With PD-1 Inhibitor and Chemotherapy in R/M Nasopharyngeal Carcinoma",
      "status": "RECRUITING",
      "last_update": "2026-05-11",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06819228",
      "title": "Window Trial of Fluorescently Labeled Panitumumab (Panitumumab-IRDye800) in Head and Neck Cancer",
      "status": "RECRUITING",
      "last_update": "2026-08-03",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06869473",
      "title": "Cetuximab Plus Platinum and Taxane-based Chemotherapy, Followed by Avelumab and Cetuximab, as First-line Treatment for Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma (HNSCC) Patients With a PD-L1 Combined Positive Score (CPS)\u22651\u226419.",
      "status": "RECRUITING",
      "last_update": "2025-03-14",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06912087",
      "title": "Dose Finding Study of Zanzalintinib With Pembrolizumab and Cetuximab in Head and Neck SCC",
      "status": "RECRUITING",
      "last_update": "2025-12-02",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06943820",
      "title": "AK129 Combination Therapy for Advanced Solid Tumors",
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     {
      "nct": "NCT06975410",
      "title": "Clinical Trial of YH32364 in Patients With Locally Advanced or Metastatic EGFR Overexpressing Solid Tumors",
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     {
      "nct": "NCT07038343",
      "title": "AVENTINE-1: Study of AVZO-1418 as a Single Agent and in Combination Therapy in Patients With Locally Advanced or Metastatic Solid Tumors (AVZO-1418-1001)",
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     {
      "nct": "NCT07063212",
      "title": "A Study of Sacituzumab Govitecan in Combination With Cetuximab in People With Head and Neck Squamous Cell Cancer (HNSCC)",
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     {
      "nct": "NCT07085091",
      "title": "A First in Human Study of ALX2004 With Advanced or Metastatic Selected Solid Tumors",
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     {
      "nct": "NCT07105592",
      "title": "A Study of Nimotuzumab Plus Adebrelimab With Chemotherapy in Cisplatin-Ineligible Patients With Head And Neck Squamous Cell Carcinoma",
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     {
      "nct": "NCT07181473",
      "title": "A Study to Evaluate the Safety, Pharmacokinetics and Efficacy of TJ101 in Patients With Advanced/Metastatic Solid Tumors",
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      "last_update": "2026-01-12",
      "phase": "PHASE1",
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     {
      "nct": "NCT07216105",
      "title": "FT836 With or Without Chemotherapy and/or Monoclonal Antibodies, in Participants With Advanced Solid Tumors",
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      "last_update": "2026-09-02",
      "phase": "PHASE1",
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     {
      "nct": "NCT07217028",
      "title": "Study Evaluating [18F]NOTA-ABY030 for Safety and Tolerability of Indeterminate Primary and/or Metastatic Disease in Head and Neck Squamous Cell Carcinoma",
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      "last_update": "2026-05-11",
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     {
      "nct": "NCT07235566",
      "title": "MRG003 and Pucotenlimab to Treat Locally Advanced or Metastatic ATC/PDTC",
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      "last_update": "2025-11-19",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT07381075",
      "title": "A Phase II Clinical Trial of Anti-EGFR Antibody-drug Conjugate (ADC) Combined With or Without Immune Checkpoint Inhibitors in the Neoadjuvant Treatment of Resectable Locally Advanced Head and Neck Squamous Cell Carcinoma",
      "status": "RECRUITING",
      "last_update": "2026-09-11",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT07403136",
      "title": "Becotatug Vedotin \u00b1 Anti-PD-1 in Pretreated Advanced ESCC",
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      "last_update": "2026-07-07",
      "phase": "PHASE2",
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     {
      "nct": "NCT07431281",
      "title": "Sonesitatug Vedotin in Combination With Capecitabine With or Without Rilvegostomig in Participants With Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma Expressing Claudin18.2",
      "status": "RECRUITING",
      "last_update": "2026-09-09",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07441681",
      "title": "Comparing Radiation Plus Cetuximab to Radiation Plus Chemotherapy in People With Head and Neck Cancer Who Cannot Receive Cisplatin",
      "status": "RECRUITING",
      "last_update": "2026-08-17",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07462377",
      "title": "A Phase 1 Study of EPI-326 in EGFR-mutant NSCLC and HNSCC",
      "status": "RECRUITING",
      "last_update": "2026-09-10",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07584499",
      "title": "Phase I Study of Becotatug Vedotin for Safety and Efficacy in EGFR-Positive Pediatric Relapsed/Refractory or Metastatic Solid Tumors",
      "status": "RECRUITING",
      "last_update": "2026-05-13",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07589205",
      "title": "Study of IBI3028 in Participants With Locally Advanced, Unresectable, or Metastatic Solid Tumors",
      "status": "RECRUITING",
      "last_update": "2026-07-23",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07617805",
      "title": "EGFR/HER2 Dual-Target CAR-NK Cells for Recurrent or Metastatic HNSCC",
      "status": "RECRUITING",
      "last_update": "2026-06-01",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07665190",
      "title": "Neoadjuvant EGFR-ADC Combined With Anti-PD-1 Monoclonal Antibody in Resectable Locally Advanced Hypopharyngeal Squamous Cell Carcinoma",
      "status": "RECRUITING",
      "last_update": "2026-07-16",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07755397",
      "title": "First in Human Multicenter Open Name Dose-increase, Consolidation Method to Study Safety Drug-level in Blood & Drug Metabolism Clinical Activity of Oral JBI-778 in Lung Cancer Patients With, Without Brain Metastasis IDH Mutated WHO Grade 3,4 Recurrent Glioma, Salivary Glands Tumor",
      "status": "RECRUITING",
      "last_update": "2026-08-10",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07814287",
      "title": "Becotatug Vedotin Plus Pucotenlimab and Platinum Chemotherapy in Locally Advanced Epidermal Growth Factor Receptor (EGFR)-Positive Head and Neck Squamous Cell Carcinoma",
      "status": "RECRUITING",
      "last_update": "2026-09-10",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00003809",
      "title": "Cisplatin With or Without Monoclonal Antibody Therapy in Treating Patients With Metastatic or Recurrent Head and Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2026-02-27",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00004227",
      "title": "Radiation Therapy With or Without Cetuximab in Treating Patients With Stage III or Stage IV Cancer of the Oropharynx, Hypopharynx, or Larynx",
      "status": "TERMINATED",
      "last_update": "2014-02-06",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00004865",
      "title": "Cetuximab Plus Cisplatin in Treating Patients With Metastatic or Recurrent Cancer of the Head and Neck That Has Not Responded to Cisplatin Chemotherapy",
      "status": "COMPLETED",
      "last_update": "2009-03-09",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00004879",
      "title": "Monoclonal Antibody ABX-EGF in Treating Patients With Renal (Kidney), Prostate, Pancreatic, Non-Small Cell Lung, Colon or Rectal, Esophageal, or Gastroesophageal Junction Cancer",
      "status": "COMPLETED",
      "last_update": "2013-01-08",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00005814",
      "title": "Cetuximab, Cisplatin, and Radiation Therapy in Treating Patients With Advanced Stage III or Stage IV Head and Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2013-06-19",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00009841",
      "title": "Gene Therapy in Treating Patients With Advanced Head and Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2016-02-12",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00049283",
      "title": "Erlotinib, Docetaxel, and Radiation Therapy in Treating Patients With Locally Advanced Head and Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2014-06-06",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00083057",
      "title": "Gefitinib, Paclitaxel, and Radiation Therapy in Treating Patients With Advanced or Recurrent Squamous Cell Carcinoma of the Head and Neck",
      "status": "COMPLETED",
      "last_update": "2012-03-15",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00084318",
      "title": "Adjuvant Cetuximab and Chemoradiotherapy Using Either Cisplatin or Docetaxel in Treating Patients With Resected Stage III or Stage IV Squamous Cell Carcinoma or Lymphoepithelioma of the Head and Neck",
      "status": "COMPLETED",
      "last_update": "2018-12-12",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00089297",
      "title": "Cetuximab, Chemotherapy, and Radiation Therapy for Operable Stage III or IV Head and Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2023-06-29",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00093041",
      "title": "Zalutumumab in Head and Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2023-06-28",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00095563",
      "title": "Lapatinib in Treating Patients With Recurrent and/or Metastatic Adenoid Cystic Cancer or Other Salivary Gland Cancers",
      "status": "COMPLETED",
      "last_update": "2017-04-18",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00096174",
      "title": "Phase II Study of Concurrent C225, Cisplatin and Radiation in Stage IV Squamous Cell Carcinoma of the Head and Neck",
      "status": "COMPLETED",
      "last_update": "2023-06-29",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00101348",
      "title": "Erlotinib and Cetuximab With or Without Bevacizumab in Treating Patients With Metastatic or Unresectable Kidney, Colorectal, Head and Neck, Pancreatic, or Non-Small Cell Lung Cancer",
      "status": "COMPLETED",
      "last_update": "2014-06-11",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00101907",
      "title": "Safety of AMG 706 Plus Panitumumab Plus Gemcitabine-Cisplatin in the Treatment of Patients With Advanced Cancer",
      "status": "TERMINATED",
      "last_update": "2014-03-20",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00113581",
      "title": "Safety Study of EMD 72000 in Combination With ECX (Epirubicin, Cisplatin and Capecitabine) in Oesophagogastric Cancer",
      "status": "COMPLETED",
      "last_update": "2014-02-19",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00122460",
      "title": "Cetuximab (Erbitux) in Combination With Cisplatin or Carboplatin and 5-Fluorouracil in the First Line Treatment of Subjects With Recurrent and/or Metastatic Squamous Cell Carcinoma of the Head and Neck (EXTREME)",
      "status": "COMPLETED",
      "last_update": "2014-07-23",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00140556",
      "title": "Angiogenic and EGFR Blockade With Curative Chemoradiation for Advanced Head and Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2013-01-18",
      "phase": "EARLY_PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00165490",
      "title": "Combination Chemotherapy, Radiation Therapy and Surgery for Esophageal Cancer",
      "status": "COMPLETED",
      "last_update": "2014-11-10",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00215644",
      "title": "Matuzumab Treatment With Epirubicin, Cisplatin and Capecitabine (ECX) in Esophago-Gastric Cancer",
      "status": "COMPLETED",
      "last_update": "2018-11-02",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00226239",
      "title": "Docetaxel, Cetuximab and Cisplatin Followed by Radiation, Cetuximab and Cisplatin in Head and Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2017-07-11",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00251381",
      "title": "Cetuximab & Concomitant-Boost Accelerated RT in Patients With Locally Advanced Oropharynx Squamous Cell Carcinoma.",
      "status": "UNKNOWN",
      "last_update": "2006-10-26",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00291707",
      "title": "Trial of Cetuximab and Pemetrexed With Radiation in Head and Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2013-05-06",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00314262",
      "title": "Phase I/II Study of Chemoprevention With EGFR and COX-2 Inhibitor",
      "status": "COMPLETED",
      "last_update": "2014-10-24",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00319735",
      "title": "Cetuximab and Radiation Therapy for Surgically Resectable Esophageal and Gastroesophageal (GE) Junction Carcinomas",
      "status": "COMPLETED",
      "last_update": "2016-04-28",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00343083",
      "title": "Evaluation of Cetuximab (ERBITUX) and Concurrent Carboplatin, Paclitaxel & Radiotherapy in the Management of Patients With Advanced Locoregional Squamous Cell Carcinomas of the Head and Neck (GCC 0442)",
      "status": "COMPLETED",
      "last_update": "2019-08-19",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00371566",
      "title": "A Study Of Lapatinib Versus Placebo Followed By Chemoradiation In Patients With Locally Advanced Head And Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2010-04-06",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00381706",
      "title": "Combination Chemotherapy and Cetuximab in Treating Patients With Metastatic Esophageal Cancer or Gastroesophageal Junction Cancer",
      "status": "COMPLETED",
      "last_update": "2021-09-29",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00382031",
      "title": "Zalutumumab in Patients With Non-curable Head and Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2013-10-15",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00387127",
      "title": "Lapatinib Versus Placebo Given Concurrently With Cisplatin And Radiotherapy In Patients With Unresected Head And Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2015-06-25",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00397384",
      "title": "Erlotinib Hydrochloride and Cetuximab in Treating Patients With Advanced Gastrointestinal Cancer, Head and Neck Cancer, Non-Small Cell Lung Cancer, or Colorectal Cancer",
      "status": "COMPLETED",
      "last_update": "2015-09-30",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00397904",
      "title": "Cetuximab, Cisplatin, and Irinotecan in Treating Patients With Metastatic Esophageal Cancer, Gastroesophageal Junction Cancer, or Gastric Cancer That Did Not Respond to Previous Irinotecan and Cisplatin",
      "status": "COMPLETED",
      "last_update": "2015-11-25",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00400374",
      "title": "Secondary Primary Tumor Prevention With EGFR, OSI-774, and Cyclooxygenase-2",
      "status": "COMPLETED",
      "last_update": "2018-03-15",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00401401",
      "title": "Zalutumumab in Combination With Chemotherapy and Radiotherapy in Head and Neck Cancer",
      "status": "TERMINATED",
      "last_update": "2011-12-23",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00409565",
      "title": "A Phase II Trial of Cetuximab and Bevacizumab in Patients With Recurrent or Metastatic Head and Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2017-10-20",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00424255",
      "title": "Study Of Adjuvant Lapatinib In High-Risk Head And Neck Cancer Subjects After Surgery",
      "status": "COMPLETED",
      "last_update": "2014-07-18",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00425425",
      "title": "Cetuximab, Oxaliplatin, Fluorouracil, and Radiation Therapy in Treating Patients With Stage II or Stage III Esophageal Cancer",
      "status": "UNKNOWN",
      "last_update": "2014-05-01",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00439608",
      "title": "Cetuximab, Paclitaxel, Carboplatin & Radiation for Esoph, Gastroesoph & Gastric Cancer",
      "status": "COMPLETED",
      "last_update": "2020-02-17",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00446446",
      "title": "PRISM (Panitumumab Regimen In Second-line Monotherapy of Head and Neck Cancer)",
      "status": "COMPLETED",
      "last_update": "2022-10-05",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00454779",
      "title": "PARTNER: Panitumumab Added to Regimen for Treatment of Head aNd Neck Cancer Evaluation of Response",
      "status": "COMPLETED",
      "last_update": "2018-10-17",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00460265",
      "title": "Study of Panitumumab Efficacy in Patients With Recurrent and/or Metastatic Head and Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2014-03-07",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00496652",
      "title": "DAHANCA 19: The Importance of the EGFr-inhibitor Zalutumumab for the Outcome After Curative Radiotherapy for HNSCC",
      "status": "COMPLETED",
      "last_update": "2016-11-25",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00500760",
      "title": "Study of Addition of Panitumumab to Chemoradiation Therapy in Patients With Locally Advanced Head and Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2018-10-17",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00502463",
      "title": "Induction Chemotherapy Prior to Radio-immunotherapy in Head and Neck Cancer Stage III/IV - a Methodical Trial",
      "status": "COMPLETED",
      "last_update": "2024-02-07",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00509002",
      "title": "Iressa Study in Patients With Salivary Gland Cancer",
      "status": "COMPLETED",
      "last_update": "2017-11-24",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00509561",
      "title": "Cisplatin, Capecitabine, and Radiation Therapy With or Without Cetuximab in Treating Patients With Esophageal Cancer",
      "status": "UNKNOWN",
      "last_update": "2012-12-18",
      "phase": "PHASE2/PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00513383",
      "title": "Panitumumab Chemoradiotherapy Chemotherapy for Squamous Cancer of the Head and Neck",
      "status": "COMPLETED",
      "last_update": "2017-03-01",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00524017",
      "title": "Cetuximab in Treating Patients With Precancerous Lesions of the Upper Aerodigestive Tract",
      "status": "COMPLETED",
      "last_update": "2020-03-12",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00542308",
      "title": "Zalutumumab in Non-curable Patients With SCCHN",
      "status": "COMPLETED",
      "last_update": "2023-08-03",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00547157",
      "title": "Radiotherapy Plus Panitumumab Compared to Chemoradiotherapy With Unresected, Locally Advanced Squamous Cell Carcinoma of the Head and Neck",
      "status": "COMPLETED",
      "last_update": "2017-03-15",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00578071",
      "title": "Phase I/II Study of Panitumumab, Capecitabine and Oxaliplatin w EBRT for Esophageal Cancer",
      "status": "COMPLETED",
      "last_update": "2015-07-02",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00591149",
      "title": "Oxaliplatin and Docetaxel Followed by Cetuximab for Head and Neck Cancer",
      "status": "TERMINATED",
      "last_update": "2017-06-14",
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     {
      "nct": "NCT00599131",
      "title": "Cetuximab and Radiation Therapy in Laryngeal Cancer Patients Who Have Responded to One Cycle of Chemotherapy (SPORE)",
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      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00609284",
      "title": "Randomized Trial of Concomitant Chemotherapy in Patients With Locally Advanced HNSCC Treated by Radiotherapy-erbitux",
      "status": "COMPLETED",
      "last_update": "2020-04-15",
      "phase": "PHASE3",
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     {
      "nct": "NCT00622674",
      "title": "Bortezomib and Cetuximab in Treating Patients With Advanced Solid Tumors",
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      "last_update": "2017-12-02",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00628368",
      "title": "Biological Factors in Predicting Response to Treatment in Patients With Esophageal Cancer or Rectal Cancer",
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      "last_update": "2026-02-10",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00660218",
      "title": "A Phase I/II Study of Radiation Therapy, Paclitaxel Poliglumex and Cetuximab in Advanced Head and Neck Cancer",
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      "last_update": "2021-11-08",
      "phase": "PHASE1/PHASE2",
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     {
      "nct": "NCT00661427",
      "title": "Cetuximab at Either 500 or 750 mg/m2 Every Other Week for Recurrent or Metastatic Head and Neck Squamous Cell Cancer",
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      "last_update": "2018-01-11",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00665392",
      "title": "Cetuximab and Combination Chemotherapy in Patients With Stage III-IV Resectable Oropharynx Cancer",
      "status": "COMPLETED",
      "last_update": "2025-08-01",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00671437",
      "title": "Determine Tumor Response Using Fluorodeoxyglucose (FDG)- Positron Emission Tomography (PET)/Computed Tomography (CT) Before and After Cetuximab in Patients With Head and Neck Cancer",
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      "last_update": "2017-03-14",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00681967",
      "title": "Postoperative Radiotherapy Plus Iressa or Radiotherapy Plus Cisplatin and Iressa for Advanced Head & Neck Cancer",
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      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00686114",
      "title": "Concurrent Chemoradiotherapy Containing Paclitaxel&Cisplatin With/Without Tarceva in Locally Advanced Esophageal Cancer",
      "status": "UNKNOWN",
      "last_update": "2014-04-29",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00704639",
      "title": "Chemoradiation Treatment for Head and Neck Cancer",
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      "last_update": "2017-07-12",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00705016",
      "title": "Cilengitide in Recurrent and/or Metastatic Squamous Cell Carcinoma of the Head and Neck (SCCHN)",
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      "last_update": "2014-04-30",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00707655",
      "title": "Zalutumumab in Combination With Radiotherapy in Head and Neck Cancer Patients Ineligible for Platinum Based Chemotherapy",
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      "last_update": "2023-08-03",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00713219",
      "title": "Docetaxel + Cetuximab + Concurrent Re-Irradiation (Intensity - Modulated Radiation Therapy, IMRT) for Patients With Locoregionally Recurrent Head and Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2015-04-23",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00714649",
      "title": "Neoadjuvant Cetuximab in HNSCC Combined With Curative Surgery",
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      "last_update": "2012-11-14",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00720304",
      "title": "Erlotinib, Docetaxel, and Radiation Therapy in Stage III or Stage IV Squamous Cell Carcinoma of the Head and Neck",
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      "last_update": "2024-08-22",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00735345",
      "title": "Chemotherapy Induction and Chemoradiotherapy in Patients With Esophageal Carcinoma",
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      "last_update": "2015-03-09",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00736619",
      "title": "Weekly Nanoparticle Albumin-Bound Paclitaxel (Abraxane) + Weekly Cetuximab + Radiation Therapy (IMRT, Intensity-Modulated Radiation Therapy) in Patients With Stage III-IVB Head and Neck Squamous Cell Carcinoma (HNSCC)",
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      "last_update": "2016-08-10",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00736944",
      "title": "Trial of 2 Cycles of Induction Chemo With Abraxane, Cetuximab, Cisplatin, & 5-FU for Advanced Head and Neck Cancer",
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      "last_update": "2020-09-09",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00738868",
      "title": "Cetuximab and Stereotactic Radiation Therapy in Treating Patients With Recurrent Head and Neck Cancer That Cannot Be Removed By Surgery",
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      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00756444",
      "title": "A Randomized Phase 2 Pharmacokinetic Trial of Chemotherapy With or Without Panitumumab in Patients With Metastatic and/or Recurrent Squamous Cell Carcinoma of the Head and Neck",
      "status": "COMPLETED",
      "last_update": "2018-11-15",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00757172",
      "title": "Panitumumab, Docetaxel, Cisplatin, Radiation Therapy, and Surgery in Treating Patients With Newly Diagnosed, Locally Advanced Esophageal Cancer or Cancer of the Gastroesophageal Junction",
      "status": "COMPLETED",
      "last_update": "2016-03-11",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00765011",
      "title": "TPF Plus Radiotherapy and Cetuximab to Avoid Total Laryngectomy in Patients With Larynx Cancer",
      "status": "COMPLETED",
      "last_update": "2019-04-11",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00779389",
      "title": "Comparison of Biomarker Modulation by Inhibition of EGFR and/or SRC Family",
      "status": "COMPLETED",
      "last_update": "2016-01-13",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00798655",
      "title": "Trial of Postoperative Radiation, Cisplatin, and Panitumumab in Locally Advanced Head and Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2017-10-03",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00820248",
      "title": "Radiation + Cisplatin or Panitumumab in Locally Advanced Stage III or Stage IV Head and Neck Cancer",
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      "last_update": "2023-08-22",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00820417",
      "title": "Pharmocokinetic/Pharmacodynamic (PK/PD) Study of the Combination Cetuximab/Gefitinib",
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      "last_update": "2009-01-12",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00833261",
      "title": "Nab-Paclitaxel, Cetuximab, Cisplatin, and Radiation Therapy in Treating Patients With Recurrent Head and Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2020-08-21",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00836277",
      "title": "Phase II Study of Irinotecan and Panitumumab",
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      "last_update": "2016-11-15",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00841191",
      "title": "A Safety, Efficacy and Pharmacokinetic Study of Siltuximab (CNTO 328) in Participants With Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2014-05-14",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00851877",
      "title": "Nab-Paclitaxel, Cisplatin, and Cetuximab With Concurrent Radiation Therapy for Locally Advanced Head and Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2020-08-21",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00868491",
      "title": "Induction Chemotherapy Followed by Chemoradiation With Cetuximab in Head and Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2024-10-18",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00891904",
      "title": "Radiation Therapy and Cetuximab in Treating Patients With Recurrent Head and Neck Cancer",
      "status": "TERMINATED",
      "last_update": "2016-04-14",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00906360",
      "title": "Sunitinib, Cetuximab, and Radiation Therapy in Treating Patients With Locally Advanced or Recurrent Squamous Cell Carcinoma of the Head and Neck",
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      "last_update": "2013-07-02",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00908024",
      "title": "Combination Study of BMS-754807 and Erbitux\u00ae in Subjects With Advanced or Metastatic Solid Tumors",
      "status": "TERMINATED",
      "last_update": "2013-06-18",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00933387",
      "title": "A Study of Neoadjuvant Bio-C/T Followed by Concurrent Bio-R/T in High-risk Locally Advanced Oral Squamous Cell Carcinoma",
      "status": "COMPLETED",
      "last_update": "2016-05-04",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00934518",
      "title": "Image Guided Intensity Modulated Reirradiation (IG-IMRT) With Cetuximab for Locoregionally Confined Recurrent Head and Neck Squamous Cell Carcinoma",
      "status": "WITHDRAWN",
      "last_update": "2019-02-12",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00939627",
      "title": "Phase II Randomized Trial of the Combination of Cetuximab and Sorafenib or Single Agent Cetuximab",
      "status": "COMPLETED",
      "last_update": "2026-03-10",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00956007",
      "title": "RT With or Without Cetuximab in Treating Patients Who Have Undergone Surgery for Locally Advanced Head and Neck Cancer",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-01-06",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00957853",
      "title": "Preoperative Treatment With Cetuximab and/or IMC-A12",
      "status": "COMPLETED",
      "last_update": "2020-03-19",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00968435",
      "title": "Bevacizumab, Cetuximab, and Cisplatin With IMRT (Intensity-Modulated Radiation Therapy) for Patients With Stage III/IV Head and Neck Squamous Cell Carcinoma",
      "status": "COMPLETED",
      "last_update": "2016-08-10",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00970502",
      "title": "Erlotinib, Celecoxib and Reirradiation for Recurrent Head and Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2017-04-10",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01009346",
      "title": "RAD001 in Combination With Cetuximab and Cisplatin in Recurrent and Metastatic SCCHN",
      "status": "TERMINATED",
      "last_update": "2018-07-17",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01015664",
      "title": "Combination of Cisplatin, Cetuximab and Temsirolimus in Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck",
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      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01034189",
      "title": "Cetuximab/Paclitaxel/Cisplatin Concurrent Chemoradiotherapy Followed by Esophagectomy for Loco-regional Esophageal Cancer",
      "status": "UNKNOWN",
      "last_update": "2009-12-17",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01054625",
      "title": "Zalutumumab Pharmacokinetics (PK) in Squamous Cell Carcinoma of the Head and Neck (SCCHN)",
      "status": "COMPLETED",
      "last_update": "2023-08-03",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01077999",
      "title": "Chemoradiation and Panitumumab for Esophageal Cancer",
      "status": "COMPLETED",
      "last_update": "2021-04-21",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01081041",
      "title": "A Study in Head and Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2019-09-25",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01087970",
      "title": "A Study for Participants With Recurrent or Metastatic Squamous Cell Head and Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2014-05-19",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01099358",
      "title": "Study in Advanced Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2019-09-26",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01128387",
      "title": "Trial of Panitumumab/Cisplatin/Fluorouracil Combined With Radiation in Esophageal Cancer",
      "status": "TERMINATED",
      "last_update": "2019-12-09",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01133665",
      "title": "Cetuximab and Lenalidomide in Head and Neck",
      "status": "COMPLETED",
      "last_update": "2014-11-24",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01142414",
      "title": "Chemotherapy and Radiation Therapy With or Without Panitumumab in Treating Patients Who Have Undergone Surgery for Advanced Hypopharyngeal Cancer, Oropharyngeal Cancer, Laryngeal Cancer, or Oral Cavity Cancer at High Risk of Recurrence",
      "status": "WITHDRAWN",
      "last_update": "2012-01-16",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01166035",
      "title": "Lenalidomide and Cetuximab in Patients With Advanced Solid Tumors",
      "status": "UNKNOWN",
      "last_update": "2010-07-20",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01177956",
      "title": "A Trial to Determine the Safety and Anti-tumor Activity Profile of the Combination of Cetuximab and Concomitant Cisplatin Plus 5-Fluorouracil (5-FU) in Subjects With Recurrent and/or Metastatic Squamous Cell Carcinoma in Head and Neck",
      "status": "COMPLETED",
      "last_update": "2014-09-03",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01181401",
      "title": "InductionChemo-Radio-Antibody-Treatment",
      "status": "COMPLETED",
      "last_update": "2019-01-31",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01212627",
      "title": "Ridaforolimus With Cetuximab: Adv Non-Small Cell Lung, Colorectal, Head & Neck Cancer",
      "status": "TERMINATED",
      "last_update": "2021-02-16",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01216020",
      "title": "Cetuximab Plus Radiotherapy Versus Cisplatin Plus Radiotherapy in Locally Advanced Head and Neck Cancer",
      "status": "TERMINATED",
      "last_update": "2018-01-17",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01218048",
      "title": "ERBITUX\u00ae Followed by Adjuvant Treatment With Chemoradiation and ERBITUX\u00ae for Locally Advanced Head and Neck Squamous Cell Carcinoma",
      "status": "COMPLETED",
      "last_update": "2018-08-16",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01221753",
      "title": "Docetaxel/Cisplatin/5-Fluorouracil (TPF) Human Papillomavirus (HPV) Squamous Cell Carcinoma Study",
      "status": "TERMINATED",
      "last_update": "2017-12-06",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01230476",
      "title": "Induction and Concurrent Chemoradiotherapy With Cetuximab for Patients With Locally Advanced Nasopharyngeal Carcinoma",
      "status": "TERMINATED",
      "last_update": "2019-10-07",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01252628",
      "title": "Phase 1 and 2 Study of PX-866 and Cetuximab",
      "status": "COMPLETED",
      "last_update": "2018-05-16",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01254617",
      "title": "Lenalidomide and Cetuximab in Treating Patients With Advanced Colorectal Cancer or Head and Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2020-03-13",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01255800",
      "title": "Pilot Study of Cetuximab and the Hedgehog Inhibitor IPI-926 in Recurrent Head and Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2014-01-31",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01256385",
      "title": "Temsirolimus With or Without Cetuximab in Patients With Recurrent and/or Metastatic Head and Neck Cancer Who Did Not Respond to Previous Therapy",
      "status": "COMPLETED",
      "last_update": "2017-03-27",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01262183",
      "title": "Radio-chemotherapy With or Without Panitumumab (Vectibix\u00ae) in Irresectable Squamous Cell Carcinoma or Adenocarcinoma of the Oesophagus",
      "status": "TERMINATED",
      "last_update": "2012-05-11",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01262859",
      "title": "Pilot Study for Locally Advanced Head and Neck Cancer",
      "status": "WITHDRAWN",
      "last_update": "2014-01-13",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01264328",
      "title": "Study of the Combination of Panitumumab With Paclitaxel as First-line Treatment of Subjects With Head and Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2019-04-16",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01301248",
      "title": "Cisplatin Chemoradiation With or Without Cetuximab for Locoregionally Advanced Squamous Cell Carcinomas (SCC) of the Head and Neck",
      "status": "UNKNOWN",
      "last_update": "2011-05-17",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01302834",
      "title": "Radiation Therapy With Cisplatin or Cetuximab in Treating Patients With Oropharyngeal Cancer",
      "status": "COMPLETED",
      "last_update": "2026-07-20",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01305772",
      "title": "Identification of Gene Expression Signature for Panitumumab Sensitivity in Untreated Locally Advanced SCCHN",
      "status": "TERMINATED",
      "last_update": "2014-08-29",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01307956",
      "title": "Panitumumab, Combination Chemotherapy, & Radiation Therapy in Esophageal or Gastroesophageal Junction Cancer",
      "status": "TERMINATED",
      "last_update": "2023-10-26",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01312493",
      "title": "Selective IMRT for Locally Advanced Head and Neck Carcinoma With Concurrent Panitumumab",
      "status": "WITHDRAWN",
      "last_update": "2015-08-28",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01316757",
      "title": "Carboplatin, Paclitaxel, Cetuximab, and Erlotinib Hydrochloride in Treating Patients With Metastatic or Recurrent Head and Neck Squamous Cell Cancer",
      "status": "COMPLETED",
      "last_update": "2018-02-26",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01326468",
      "title": "Torisel in Addition to Standard Chemotherapy With Radiation for Advanced Head and Neck Cancer",
      "status": "WITHDRAWN",
      "last_update": "2025-09-25",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01326923",
      "title": "Induction Chemo Then Concurrent Chemoradiotherapy With Cetuximab in Locally Advanced Head and Neck Squamous Cell Cancer",
      "status": "TERMINATED",
      "last_update": "2020-10-09",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01332266",
      "title": "E7050 in Combination With Cetuximab Versus Cetuximab Alone in the Treatment of Platinum-Resistant Squamous Cell Carcinoma of the Head and Neck",
      "status": "COMPLETED",
      "last_update": "2022-01-03",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01417936",
      "title": "Sym004 in SCCHN Patients Failing Anti-EGFR Based Therapy",
      "status": "COMPLETED",
      "last_update": "2018-10-15",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01434394",
      "title": "Neoadjuvant Erbitux Based Chemotherapy for Locally Advanced Oral/Oropharyngeal Cancer",
      "status": "COMPLETED",
      "last_update": "2017-08-21",
      "phase": "PHASE2/PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01437449",
      "title": "Docetaxel, Cisplatin, and Cetuximab (TPC) in Palliative Treatment of Patients With Squamous Cell Carcinoma of the Head and Neck (SCCHN)",
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      "last_update": "2024-01-30",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01440270",
      "title": "Neo-adjuvant Erbitux-based Chemotherapy for Locally Advanced Oral/Oropharyngeal Cancer",
      "status": "COMPLETED",
      "last_update": "2020-05-05",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01443065",
      "title": "MEGA (Met or EGFR Inhibition in Gastroesophageal Adenocarcinoma): FOLFOX Alone or in Combination With AMG 102 or Panitumumab as First-line Treatment in Patients With Advanced Gastroesophageal Adenocarcinoma",
      "status": "COMPLETED",
      "last_update": "2020-11-17",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01445405",
      "title": "Radiation Therapy and Bortezomib and Cetuximab With or Without Cisplatin to Treat Head and Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2019-12-17",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01451632",
      "title": "A Safety Study of MM-121 With Cetuximab and Irinotecan in Patients With Advanced Cancers",
      "status": "COMPLETED",
      "last_update": "2016-09-08",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01468896",
      "title": "Cetuximab and Recombinant Interleukin-12 in Treating Patients With Squamous Cell Carcinoma of the Head and Neck That is Recurrent, Metastatic, or Cannot Be Removed by Surgery",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-07-29",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01472653",
      "title": "Treatment Selection According to Skin Reaction to Cetuximab",
      "status": "UNKNOWN",
      "last_update": "2011-12-13",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01488318",
      "title": "Cetuximab and Dasatinib in Recurrent Squamous Cell Carcinoma",
      "status": "TERMINATED",
      "last_update": "2018-01-05",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01520389",
      "title": "Safety Study of the Drug MM-151 in Patients With Advanced Solid Tumors Resisting Ordinary Treatment",
      "status": "COMPLETED",
      "last_update": "2018-03-21",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01534585",
      "title": "Safety and Efficacy Study of Icotinib With Intensity-modulated Radiotherapy in Nasopharyngeal Carcinoma",
      "status": "COMPLETED",
      "last_update": "2018-04-17",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01540682",
      "title": "MLN8237 in Head and Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2018-08-29",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01553032",
      "title": "Skin Changes in Head and Neck Cancer During Immuno-(Chemo-) And Radiotherapy With Erbitux\u00ae (HICARE)",
      "status": "COMPLETED",
      "last_update": "2022-05-25",
      "phase": "PHASE4",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01561014",
      "title": "Oxaliplatin, Fluorouracil, Erlotinib Hydrochloride, and Radiation Therapy Before Surgery and Erlotinib Hydrochloride After Surgery in Treating Patients With Locally Advanced Cancer of the Esophagus or Gastroesophageal Junction",
      "status": "COMPLETED",
      "last_update": "2018-07-02",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01566435",
      "title": "Induction Chemotherapy With ACF Followed by Chemoradiation Therapy for Adv. Head & Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2020-10-01",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01581970",
      "title": "Potentiation of Cetuximab by Tregs Depletion With CSA in Advanced Head & Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2019-09-11",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01602315",
      "title": "A Phase Ib/II Study of BYL719 and Cetuximab in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma",
      "status": "TERMINATED",
      "last_update": "2020-12-29",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01627379",
      "title": "Cisplatin and 5-FU +/- Panitumumab for Patients With Nonresectable,Advanced or Metastatic Esophageal Squamous Cell Cancer",
      "status": "TERMINATED",
      "last_update": "2018-03-02",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01637194",
      "title": "Cetuximab and Everolimus in Treating Patients With Metastatic or Recurrent Colon Cancer or Head and Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2012-07-11",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01663259",
      "title": "Reduced-intensity Therapy for Oropharyngeal Cancer in Non-smoking HPV-16 Positive Patients",
      "status": "COMPLETED",
      "last_update": "2021-01-19",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01693159",
      "title": "Effects of ECA on Quality of Life in Head and Neck Cancer Patients Suffering From Cetuximab-induced Rhagades",
      "status": "UNKNOWN",
      "last_update": "2017-09-25",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01737008",
      "title": "Dacomitinib Plus Radiotherapy, With and Without Cisplatin in Patients With Squamous Cell Carcinoma of the Head and Neck",
      "status": "COMPLETED",
      "last_update": "2016-06-13",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01737450",
      "title": "Activity and Safety Study of BKM120 in Monotherapy in Patient With Metastatic Head and Neck Cancer Recurrent or Progressive",
      "status": "COMPLETED",
      "last_update": "2019-06-24",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01744340",
      "title": "A Dose Finding Study of Eribulin Mesylate and Cetuximab For Patients With Advanced Head and Neck and Colon Cancer",
      "status": "COMPLETED",
      "last_update": "2020-02-17",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01758731",
      "title": "Study of Olaparib With Radiation Therapy and Cetuximab in Advanced Head and Neck Cancer With Heavy Smoking History",
      "status": "COMPLETED",
      "last_update": "2019-09-23",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01787006",
      "title": "Definitive Radiochemotherapy Plus/Minus Cetuximab in Unresectable Locally Advanced Esophageal Cancer",
      "status": "COMPLETED",
      "last_update": "2020-03-10",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01790516",
      "title": "Use of Pharmacogenetics to Select Erbitux or Cisplatin to Treat Head and Neck Cancer",
      "status": "TERMINATED",
      "last_update": "2014-10-02",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01810913",
      "title": "Testing Docetaxel-Cetuximab or the Addition of an Immunotherapy Drug, Atezolizumab, to the Usual Chemotherapy and Radiation Therapy in High-Risk Head and Neck Cancer",
      "status": "SUSPENDED",
      "last_update": "2026-09-01",
      "phase": "PHASE2/PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01836029",
      "title": "Chemotherapy Plus Cetuximab in Combination With VTX-2337 in Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck",
      "status": "COMPLETED",
      "last_update": "2019-10-29",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01855854",
      "title": "Second-line Treatment With Icotinib in Esophageal Carcinoma Patients With EGFR Overexpression (IHC 3+) or Positive FISH",
      "status": "COMPLETED",
      "last_update": "2019-07-05",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01864772",
      "title": "Phase II Trial of Carboplatin, 5-FU and Cetuximab in Elderly Fit (no Frailty) Patients With Recurrent/Metastatic HNSCC",
      "status": "COMPLETED",
      "last_update": "2022-08-19",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01874171",
      "title": "Determination of Cetuximab Versus Cisplatin Early and Late Toxicity Events in HPV+ OPSCC",
      "status": "UNKNOWN",
      "last_update": "2017-05-08",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01884259",
      "title": "Induction Chemotherapy With TP+5-FU or TP+Cetuximab Followed by Radioimmuptherapy for Locally Advanced or Not Resectable SCCHNN",
      "status": "COMPLETED",
      "last_update": "2022-05-26",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01884623",
      "title": "Phase III Trial Comparing Methotrexate and Cetuximab in First-line Treatment of Recurrent and/or Metastatic Squamous Cell Head and Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2024-02-09",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01931150",
      "title": "Study of Prophylactic Topical Dapsone 5% Gel Versus Moisturizer for Cetuximab-induced Papulopustular (Acneiform) Rash in Patients With mCRC or HNSCC Without Previous or Concurrent RT",
      "status": "COMPLETED",
      "last_update": "2017-01-13",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01935921",
      "title": "Ipilimumab, Cetuximab, and Intensity-Modulated Radiation Therapy in Treating Patients With Previously Untreated Stage III-IVB Head and Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2023-06-15",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01969877",
      "title": "A Study of Cisplatin Plus Radiotherapy Compared to Cetuximab Plus Radiotherapy in Locally Advanced Head and Neck Cancer.",
      "status": "COMPLETED",
      "last_update": "2020-09-02",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01979211",
      "title": "Post-operative Radiation With Cetuximab for Locally Advanced Cutaneous Squamous Cell Carcinoma of the Head and Neck",
      "status": "COMPLETED",
      "last_update": "2024-02-29",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02011594",
      "title": "Phase II Study of Maintenance Treatment of Nimotuzumab for Advanced Esophageal Carcinoma",
      "status": "WITHDRAWN",
      "last_update": "2015-02-12",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02034968",
      "title": "Nimotuzumab Plus Nab-paclitaxel and Cisplatin in Treating Patients With Advanced Esophageal Carcinoma",
      "status": "WITHDRAWN",
      "last_update": "2015-03-05",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02054442",
      "title": "A Study of the Combination of Cetuximab and Methotrexate in Recurrent or Metastatic Cancer of the Head and Neck",
      "status": "UNKNOWN",
      "last_update": "2021-03-12",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02057107",
      "title": "SBRT With Cetuximab +/- Docetaxel Followed by Adjuvant Cetuximab +/- Docetaxel in Recurrent, Previously-Irradiated SCCHN",
      "status": "COMPLETED",
      "last_update": "2023-06-05",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02069730",
      "title": "A Study of Drug Therapies for Salivary Gland Cancers Based on Testing of Genes",
      "status": "COMPLETED",
      "last_update": "2026-01-08",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02110082",
      "title": "Combination Study of Urelumab and Cetuximab in Patients With Advanced/Metastatic Colorectal Cancer or Advanced/Metastatic Head and Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2017-04-19",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02124707",
      "title": "Weekly Carboplatin, Paclitaxel and Cetuximab Treatment for Patients With Recurrent or Metastatic SCCHN",
      "status": "COMPLETED",
      "last_update": "2020-08-12",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02124850",
      "title": "A Phase Ib Study of Neoadjuvant of Cetuximab Plus Motolimod and Cetuximab Plus Motolimod Plus Nivolumab",
      "status": "TERMINATED",
      "last_update": "2019-10-25",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02145637",
      "title": "Phase I Study of the Combination of Afatinib and Ruxolitinib in Patients With Treatment-refractory Non-Small Cell Lung Cancer (NSCLC)",
      "status": "COMPLETED",
      "last_update": "2019-03-29",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02177838",
      "title": "Cetuximab and Radiation Therapy in Treating Patients With Stage III-IV Head and Neck Cancer",
      "status": "TERMINATED",
      "last_update": "2021-04-21",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02205398",
      "title": "Study of Safety and Efficacy of INC280 and Cetuximab, in Adult c-MET Positive mCRC and HNSCC Patients After Progression on Cetuximab or Panitumumab Therapy",
      "status": "TERMINATED",
      "last_update": "2019-01-22",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02277197",
      "title": "Ficlatuzumab and Cetuximab in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma (HNSCC)",
      "status": "COMPLETED",
      "last_update": "2019-04-18",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02281955",
      "title": "De-intensification of Radiation and Chemotherapy for Low-Risk HPV-related Oropharyngeal SCC: Follow-up Study",
      "status": "COMPLETED",
      "last_update": "2025-01-07",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02282371",
      "title": "Cetuximab + BYL719 + IMRT (Intensity-Modulated Radiation Therapy) in Stage III/IVB Head and Neck Squamous Cell Cancer (HNSCC)",
      "status": "COMPLETED",
      "last_update": "2021-10-26",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02318901",
      "title": "Pembrolizumab and Monoclonal Antibody Therapy in Advanced Cancer",
      "status": "TERMINATED",
      "last_update": "2019-10-21",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02358031",
      "title": "A Study of Pembrolizumab (MK-3475) for First Line Treatment of Recurrent or Metastatic Squamous Cell Cancer of the Head and Neck (MK-3475-048/KEYNOTE-048)",
      "status": "COMPLETED",
      "last_update": "2025-07-18",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02415881",
      "title": "Panitumumab IRDye800 Optical Imaging Study",
      "status": "COMPLETED",
      "last_update": "2021-09-24",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02429089",
      "title": "Study of LEE011plus Cetuximab in Patients With a Cancer of the Head and Neck",
      "status": "TERMINATED",
      "last_update": "2020-01-09",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02438995",
      "title": "Super-Selective Intraarterial Infusion of Cetuximab (Erbitux) With or Without Radiation Therapy for the Treatment of Unresectable Recurrent Squamous Cell Carcinoma of the Head and Neck",
      "status": "TERMINATED",
      "last_update": "2021-11-03",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02465060",
      "title": "Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-08-28",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02507154",
      "title": "Reactivating NK Cells in Treating Refractory Head and Neck Cancer",
      "status": "UNKNOWN",
      "last_update": "2018-08-21",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02538627",
      "title": "Phase 1 Combination Study of MM-151 With MM-121, MM-141, or Trametinib",
      "status": "TERMINATED",
      "last_update": "2017-09-05",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02555644",
      "title": "A Study of Prexasertib (LY2606368) With Chemotherapy and Radiation in Participants With Head and Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2019-02-15",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02627274",
      "title": "A Study Evaluating Safety, Pharmacokinetics, and Therapeutic Activity of RO6874281 as a Single Agent (Part A) or in Combination With Trastuzumab or Cetuximab (Part B or C)",
      "status": "COMPLETED",
      "last_update": "2022-11-22",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02633176",
      "title": "Cisplatin Plus Docetaxel Versus Cetuximab, Cisplatin, and Docetaxel in Metastatic Nasopharyngeal Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2015-12-17",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02633800",
      "title": "Patritumab With Cetuximab and a Platinum Agent for Squamous Cell Carcinoma (Cancer) of the Head and Neck (SCCHN )",
      "status": "TERMINATED",
      "last_update": "2019-01-07",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02636088",
      "title": "Definitive Chemoradiotherapy and Cetuximab in the Treatment of Locally Advanced Esophageal Cancer",
      "status": "UNKNOWN",
      "last_update": "2018-09-21",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02643056",
      "title": "Study to Investigate the Efficacy of Panitumumab in Platinum-resistant Advanced Head and Neck Squamous Cancer",
      "status": "COMPLETED",
      "last_update": "2021-10-27",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02707588",
      "title": "Tolerance and Efficacy of Pembrolizumab or Cetuximab Combined With RT in Patients With Locally Advanced HNSCC",
      "status": "COMPLETED",
      "last_update": "2023-02-28",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02748707",
      "title": "Effect of COX-2 and EGFR Suppression on Molecular Markers of Angiogenesis and Proliferation in Squamous Cell Carcinoma of Oral Cavity - Prospective Randomized Study",
      "status": "UNKNOWN",
      "last_update": "2022-04-28",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02764593",
      "title": "Safety Testing of Adding Nivolumab to Chemotherapy in Patients With Intermediate and High-Risk Local-Regionally Advanced Head and Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2022-11-29",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02817113",
      "title": "Study of NC-6004 in Combination With 5-FU and Cetuximab in Patients With Head and Neck Cancer",
      "status": "TERMINATED",
      "last_update": "2021-04-30",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02903914",
      "title": "Arginase Inhibitor INCB001158 as a Single Agent and in Combination With Immune Checkpoint Therapy in Patients With Advanced/Metastatic Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2025-08-05",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02938273",
      "title": "Bioimmunoradiotherapy (Cetuximab/RT/Avelumab)",
      "status": "COMPLETED",
      "last_update": "2019-12-11",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03002623",
      "title": "CUDC-907 Treatment in People With Metastatic and Locally Advanced Thyroid Cancer",
      "status": "TERMINATED",
      "last_update": "2018-12-21",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03024489",
      "title": "Palbociclib With Cetuximab and IMRT for Locally Advanced Squamous Cell Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2024-03-15",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03051906",
      "title": "Durvalumab, Cetuximab and Radiotherapy in Head Neck Cancer",
      "status": "UNKNOWN",
      "last_update": "2017-11-22",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03067610",
      "title": "Involved Field Elective Volume De-Intensification Radiation Therapy for Head and Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2022-03-17",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03070366",
      "title": "Stereotactic Radiotherapy Combined With Chemotherapy or Not for Treatment of Oligometastases in HNSCC",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-09-02",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03082534",
      "title": "Pembrolizumab Combined With Cetuximab for Treatment of Recurrent/Metastatic Head & Neck Squamous Cell Carcinoma",
      "status": "COMPLETED",
      "last_update": "2026-01-28",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03088059",
      "title": "Biomarker-based Study in R/M SCCHN",
      "status": "UNKNOWN",
      "last_update": "2023-11-03",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03094169",
      "title": "AVID100 in Advanced Epithelial Carcinomas",
      "status": "TERMINATED",
      "last_update": "2025-06-11",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03114319",
      "title": "Dose Finding Study of TNO155 in Adult Patients With Advanced Solid Tumors",
      "status": "TERMINATED",
      "last_update": "2026-07-09",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03146338",
      "title": "Prophylaxis of Magnesium-rich Mineral Water to Prevent Hypomagnesemia Induced by an Anti-EGFR (OPTIMAG)",
      "status": "UNKNOWN",
      "last_update": "2021-10-15",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03170960",
      "title": "Study of Cabozantinib Alone or in Combination With Atezolizumab to Subjects With Locally Advanced or Metastatic Solid Tumors",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-08-17",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03185988",
      "title": "Anti-HER2 Therapy in Patients of HER2 Positive Metastatic Carcinoma of Digestive System",
      "status": "UNKNOWN",
      "last_update": "2019-07-19",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03234712",
      "title": "A Study Evaluating the Safety, Pharmacokinetics, and Anti-tumor Activity of ABBV-321 in Subjects With Advanced Solid Tumors Associated With Overexpression of the Epidermal Growth Factor Receptor (EGFR)",
      "status": "COMPLETED",
      "last_update": "2021-05-06",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03246854",
      "title": "A Study of DBPR112 in Patients With Head and Neck Cancer and EGFR Mutated Lung Cancer",
      "status": "TERMINATED",
      "last_update": "2020-12-17",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03254927",
      "title": "A Study of CDX-3379 and Cetuximab and in Patients With Advanced Head and Neck Squamous Cell Carcinoma",
      "status": "TERMINATED",
      "last_update": "2023-04-03",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03258554",
      "title": "Radiation Therapy With Durvalumab or Cetuximab in Treating Patients With Locoregionally Advanced Head and Neck Cancer Who Cannot Take Cisplatin",
      "status": "COMPLETED",
      "last_update": "2026-08-27",
      "phase": "PHASE2/PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03282461",
      "title": "A Microdose Evaluation Study of ABY-029 in Head and Neck Oncology Surgery",
      "status": "COMPLETED",
      "last_update": "2023-05-18",
      "phase": "EARLY_PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03319459",
      "title": "FATE-NK100 as Monotherapy and in Combination With Monoclonal Antibody in Subjects With Advanced Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2021-11-22",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03349710",
      "title": "Nivolumab or Nivolumab Plus Cisplatin, in Combination With Radiotherapy in Patients With Cisplatin-ineligible or Eligible Locally Advanced Squamous Cell Head and Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2021-08-09",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03356223",
      "title": "Evaluation of ABEMACICLIB Monotherapy in Patients With Locally Advanced/Metastatic Head and Neck Cancer After Failure of Platinum and Cetuximab or Anti-EGFR-based Therapy and Harboring an Homozygous Deletion of CDKN2A, and/or an Amplification of CCND1 and/or of CDK6",
      "status": "COMPLETED",
      "last_update": "2023-02-23",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03386838",
      "title": "An Immuno-therapy Study of Nivolumab in Combination With Experimental Medication BMS-986205 Compared to Standard of Care EXTREME Regimen in First-line Recurrent/Metastatic Squamous Cell Carcinoma of Head and Neck",
      "status": "WITHDRAWN",
      "last_update": "2019-04-18",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03405142",
      "title": "Panitumumab-IRDye800 Compared to Sentinel Node Biopsy and (Selective) Neck Dissection in Identifying Metastatic Lymph Nodes in Patients With Head&Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2022-11-10",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03421912",
      "title": "Satisfaction and Quality of Life Comparison Between Patients Using Cicaplast Baume B5 Versus Dexeryl for the Management of Cutaneous Toxicities Induced by Epidermal Growth Factor Receptor Inhibitors (iEGFR)",
      "status": "COMPLETED",
      "last_update": "2021-07-09",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03422536",
      "title": "Ficlatuzumab w/wo Cetuximab in Patients w/Cetuximab-Resistant, Recurrent or Metastatic Head/Neck Squamous Cell Carcinoma",
      "status": "COMPLETED",
      "last_update": "2024-09-04",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03433027",
      "title": "A Study of BB-401 in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma",
      "status": "COMPLETED",
      "last_update": "2020-04-15",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03491709",
      "title": "A Preliminary Clinical Study on the Pharmacokinetics and Safety of CDP1 in Patients With Advanced CRC or HNSCC",
      "status": "COMPLETED",
      "last_update": "2026-07-06",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03498378",
      "title": "Avelumab, Cetuximab, and Palbociclib in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-04-03",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03524326",
      "title": "Testing Lenvatinib and Cetuximab in Patients With Advanced Head and Neck Squamous Cell Carcinoma and Cutaneous Squamous Cell Carcinoma",
      "status": "COMPLETED",
      "last_update": "2025-05-13",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03532737",
      "title": "Concomitant Immune Check Point Inhibitor With Radiochemotherapy in Head And Neck Cancer",
      "status": "UNKNOWN",
      "last_update": "2024-01-23",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03552406",
      "title": "Study of ISU104, Targeting ERBB3 in Patients With Advanced Solid Tumors",
      "status": "UNKNOWN",
      "last_update": "2021-05-06",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03565003",
      "title": "A First-in-Human Study of JAB-3068 (SHP2 Inhibitor) in Adult Patients With Advanced Solid Tumors in China",
      "status": "COMPLETED",
      "last_update": "2024-09-25",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03602079",
      "title": "Study of A166 in Patients With Relapsed/Refractory Cancers Expressing HER2 Antigen or Having Amplified HER2 Gene",
      "status": "COMPLETED",
      "last_update": "2023-08-03",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03645928",
      "title": "Study of Autologous Tumor Infiltrating Lymphocytes in Patients With Solid Tumors",
      "status": "TERMINATED",
      "last_update": "2026-05-15",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03646461",
      "title": "Trial of Ibrutinib Combined With Nivolumab or Cetuximab to Treat Recurrent/Metastatic HNSCC",
      "status": "TERMINATED",
      "last_update": "2026-05-22",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03693612",
      "title": "GSK3359609 Plus Tremelimumab for the Treatment of Advanced Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2024-08-28",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03713372",
      "title": "Safety and Efficacy of SCT200 in Head and Neck Squamous Cell Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2020-03-23",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03733210",
      "title": "Panitumumab-IRDye800 and 89Zr-Panitumumab in Identifying Metastatic Lymph Nodes in Patients With Squamous Cell Head and Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2023-05-19",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03769311",
      "title": "Cetuximab in Head and Neck Cancer Patients",
      "status": "COMPLETED",
      "last_update": "2023-05-24",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03769506",
      "title": "ASP-1929 Photoimmunotherapy (PIT) Study in Recurrent Head/Neck Cancer for Patients Who Have Failed at Least Two Lines of Therapy",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-01-16",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03811652",
      "title": "A Multiple Ascending Dose Study of MEDI7247 in Advanced or Metastatic Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2019-12-30",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03817567",
      "title": "Safety and Efficacy of SCT200 in Patients With Advanced Esophageal Squamous Cell Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2019-01-25",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03874741",
      "title": "SCT200 Plus Platinum-based Chemotherapy in Head and Neck Squamous Cell Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2020-05-27",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03887442",
      "title": "Paclitaxel vs Paclitaxel + Cetuximab in Recurrent - Metastatic Head & Neck Carcinoma After Failure of a 1\u00ba Chemotherapy",
      "status": "TERMINATED",
      "last_update": "2021-01-07",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03888092",
      "title": "Z650 in Advanced Esophageal Squamous Cell Carcinoma With EGFR Over Expression or Gene Amplification",
      "status": "COMPLETED",
      "last_update": "2023-03-21",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03940976",
      "title": "Afatinib in Previously Treated ESCC With EGFR Overexpression or EGFR Amplification (ESCC-A01)",
      "status": "UNKNOWN",
      "last_update": "2019-06-11",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03953976",
      "title": "INRT-AIR: A Prospective Phase II Study of Involved Nodal Radiation Therapy",
      "status": "COMPLETED",
      "last_update": "2026-02-19",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03992664",
      "title": "Education Intervention in Patients with Rash Due to Epidermal Growth Factor Receptor (EGFR) Treatment.",
      "status": "COMPLETED",
      "last_update": "2025-02-13",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04045496",
      "title": "A First-in-Human, Phase 1 Study of JAB-3312 in Adult Patients With Advanced Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2025-12-29",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04065555",
      "title": "Intratumoral Microdosing of TAK-981 in Head and Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2022-07-29",
      "phase": "EARLY_PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04091867",
      "title": "sEphB4-HSA With RT+Chemo or Cetux in Patients With Intermediate to High Risk LAHNSCC",
      "status": "COMPLETED",
      "last_update": "2025-02-24",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04106362",
      "title": "Radiation Therapy and Cisplatin With or Without Cetuximab in Treating Patients With HPV Positive, KRAS-Variant Stage III-IV Oropharyngeal Squamous Cell Carcinoma",
      "status": "TERMINATED",
      "last_update": "2023-06-01",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04121286",
      "title": "A Study of JAB-3312 in Adult Patients With Advanced Solid Tumors in China",
      "status": "COMPLETED",
      "last_update": "2025-05-20",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04161560",
      "title": "Cetuximab - IRDye800 Intraoperative Fluorescence Imaging in Esophagectomy of Esophageal Cancer",
      "status": "UNKNOWN",
      "last_update": "2019-11-13",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04225117",
      "title": "A Study to Evaluate Enfortumab Vedotin in Subjects With Locally Advanced or Metastatic Malignant Solid Tumors (EV-202)",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-06-16",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04229459",
      "title": "Trial of Nivolumab and Cetuximab After Chemoradiation in Esophageal Squamous Cell Carcinoma Patients.",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-01-14",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04278092",
      "title": "Paclitaxel Plus Cetuximab After First-line Checkpoint Inhibitor Failure",
      "status": "COMPLETED",
      "last_update": "2025-05-08",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04282109",
      "title": "Study to Assess the Efficacy and Safety of Nivolumab in Combination With Paclitaxel in Subjects With Head and Neck Cancer Unable for Cisplatin-based Chemotherapy (NIVOTAX)",
      "status": "COMPLETED",
      "last_update": "2025-06-26",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04290546",
      "title": "CIML NK Cell in Head & Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2026-07-30",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04297995",
      "title": "Evaluate the Efficacy and Safety of HLX10 in Combination With HLX07 in Patients With Advanced Head and Neck Tumors",
      "status": "UNKNOWN",
      "last_update": "2023-08-08",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04305795",
      "title": "An Open-label Study Using ASP-1929 Photoimmunotherapy in Combination With Anti-PD1 Therapy in EGFR Expressing Advanced Solid Tumors",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-06-19",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04349267",
      "title": "Study of BMS-986315 Alone and in Combination With Nivolumab or Cetuximab in Participants With Advanced Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2025-12-17",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04428151",
      "title": "Lenvatinib (E7080/MK-7902) in Combination With Pembrolizumab (MK-3475) vs. Standard Chemotherapy and Lenvatinib Monotherapy in Participants With Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma That Progressed After Platinum Therapy and Immunotherapy (MK-7902-009/E7080-G000-228/LEAP-009)",
      "status": "COMPLETED",
      "last_update": "2025-12-04",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04464967",
      "title": "Safety and Preliminary Efficacy of SNK01 in Combination With Trastuzumab or Cetuximab in Subjects With Advanced HER2 or EGFR Cancers",
      "status": "WITHDRAWN",
      "last_update": "2021-05-12",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04485013",
      "title": "TTX-080 HLA-G Antagonist in Subjects With Advanced Cancers",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-09-11",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04508816",
      "title": "Anti-EGFR Therapy Plus IMRT Concurrent Chemoradiotherapy in Locally Advanced NPC Resistant to Induction Chemotherapy",
      "status": "COMPLETED",
      "last_update": "2022-04-04",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04508829",
      "title": "Anti-EGFR Therapy With IMRT Concurrent Chemoradiotherapy in Locally Advanced OPC Resistant to Induction Chemotherapy",
      "status": "UNKNOWN",
      "last_update": "2022-04-04",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04584008",
      "title": "Targeted Agent Evaluation in Digestive Cancers in China Based on Molecular Characteristics",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2024-10-15",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04603287",
      "title": "A Study of SI-B001, an EGFR/HER3 Bispecific Antibody, in Locally Advanced or Metastatic Epithelial Tumors",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-09-26",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04616196",
      "title": "Study of NKTR 255 in Combination With Cetuximab in Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2025-06-08",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04670679",
      "title": "A Dose Escalation/Expansion Study of ERAS-601 in Patients With Advanced or Metastatic Solid Tumors",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-03-25",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04840472",
      "title": "Study Evaluating 111In-Panitumumab for Nodal Staging in Head and Neck Cancer",
      "status": "SUSPENDED",
      "last_update": "2025-12-24",
      "phase": "PHASE1",
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      "nct": "NCT04844073",
      "title": "A Study of TAK-186 (Also Known as MVC-101) in Adults With Advanced or Metastatic Cancer",
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      "nct": "NCT04856631",
      "title": "A Study of Toripalimab Injection (JS001) + Cetuximab in Treatment of Advanced Head and Neck Squamous Cell Cancer",
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     {
      "nct": "NCT04868162",
      "title": "A Study to Evaluate the Efficacy and Safety of MRG003 in Patients With Recurrent or Metastatic Squamous Cell Carcinoma of Head and Neck",
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     {
      "nct": "NCT04878692",
      "title": "Evaluation of a Cosmetic Product to Preserve Skin Conditions When Using Anti-EGFR Cancer Therapies",
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      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT04880811",
      "title": "Afatinib Plus Toripalimab in Previously Treated ESCC With EGFR Overexpression or EGFR Amplification",
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      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT04883281",
      "title": "A Prospective Study of Daily Adaptive Radiotherapy to Better Organ-at-Risk Doses in Head and Neck Cancer",
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     {
      "nct": "NCT04916002",
      "title": "A Trial To Find Out If Vidutolimod Together With Cemiplimab Is Safe And If It Works In Adult Participants With Advanced Cancer Or Metastatic Cancer",
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      "nct": "NCT04946968",
      "title": "Phase-2 Dacomitinib Study on Patients With EGFR-Driven Advanced Solid Tumours With Low EGFR-AS1 IncRNA Expr or Other Novel Emerging Biomarkers",
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     {
      "nct": "NCT05044897",
      "title": "A Clinical Study to Evaluate the Efficacy and Safety of SI-B001 in the Treatment of Recurrent and Metastatic HNSCC",
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      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT05063552",
      "title": "Testing the Use of Investigational Drugs Atezolizumab and/or Bevacizumab With or Without Standard Chemotherapy in the Second-Line Treatment of Advanced-Stage Head and Neck Cancers",
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      "last_update": "2026-07-31",
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     {
      "nct": "NCT05069935",
      "title": "FT538 in Combination With Monoclonal Antibodies in Advanced Solid Tumors",
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      "last_update": "2023-09-21",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT05099549",
      "title": "Safety, Tolerability, and Anti-Tumor Activity of AFM24 in Combination With SNK01 in Subjects With Advanced/Metastatic EGFR-Expressing Cancers",
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      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT05126719",
      "title": "A Study to Evaluate the Efficacy and Safety of MRG003 in Patients With Recurrent Metastatic Nasopharyngeal Carcinoma",
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      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT05249426",
      "title": "A Study to Test Whether Different Combinations of BI 765063, Ezabenlimab, Chemotherapy, Cetuximab, and BI 836880 Help People With Head and Neck Cancer or Liver Cancer",
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      "last_update": "2026-07-07",
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      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT05265013",
      "title": "ASP-1929 Photoimmunotherapy Combined With Pembrolizumab in Patients With Recurrent Head and Neck Cancer, With or Without Metastases",
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      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT05393635",
      "title": "ITIL-168 in Advanced Solid Tumors",
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      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT05395052",
      "title": "FT536 Monotherapy and in Combination With Monoclonal Antibodies in Advanced Solid Tumors",
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      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT05423197",
      "title": "89Zr-Panitumumab for Assessment of Suspected Metastatic Lesions on 18F-FDG-PET/CT in HNSCC",
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      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT05516589",
      "title": "Neoadjuvant Chemotherapy, Tislelizumab With Afatinib for HNSCC",
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      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT05517330",
      "title": "Neoadjuvant Tislelizumab With Afatinib for Resectable Head and Neck Squamous Cell Carcinoma",
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      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT05597839",
      "title": "Study of DF9001 in Patients With Advanced Solid Tumors",
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      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT05674526",
      "title": "A Phase 1b Study of WU-NK-101 in Combination With Cetuximab",
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      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT05704985",
      "title": "Evaluating Safety and Biomarkers Using DK210 (EGFR) for Locally Advanced or Metastatic EGFR+ Tumors",
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      "last_update": "2025-05-29",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT05816785",
      "title": "Pilot Study of Imatinib Cetuximab Combo for H & N Cancer",
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      "phase": "EARLY_PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT05930938",
      "title": "Study Comparing RT With Cetuximab + Xevinapant to RT With Cetuximab-placebo in Patients With Head and Neck Cancer",
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      "last_update": "2025-05-09",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06022276",
      "title": "Nimotuzumab for EGFR-amplified Advanced Pan Solid Tumors",
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      "last_update": "2023-09-01",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06046482",
      "title": "Phase II Trial of Magrolimab and Cetuximab With Pembrolizumab or Docetaxel for Recurrent/Metastatic Head Neck Squamous Cell Carcinoma",
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      "last_update": "2025-10-22",
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      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06081582",
      "title": "Toripalimab in Combined With Cetuximab\uff0cChemotherapy for Conversion Therapy of Locally Nonresectable OCSCC",
      "status": "UNKNOWN",
      "last_update": "2023-10-13",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06147037",
      "title": "A Phase 1, Dose-escalation Study of [225Ac]-FPI-2068 in Adult Patients With Advanced Solid Tumours",
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      "last_update": "2026-07-07",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06156878",
      "title": "PD-1 Inhibitor Plus Anti-EGFR Therapy And Radiotherapy in Locally Advanced NPC Resistant to Induction Chemotherapy",
      "status": "UNKNOWN",
      "last_update": "2023-12-05",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06332092",
      "title": "FID-007 and Cetuximab in Treating Patients With Advanced Head and Neck Squamous Cell Carcinoma",
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      "last_update": "2026-03-16",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06508606",
      "title": "AK117 (Anti-CD47 mAb) Plus Cetuximab or AK104 (Anti-PD-1/CTLA-4 bsAb) as Second-Line Therapy in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-08-19",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06509997",
      "title": "A Phase II Study of Anti-EGFR Antibody-drug Conjugate (ADC) Combine With CDK4/6 Inhibitors Posterior Line in the Treatment of Recurrent/Metastatic CDKN2A Gene Variant Head and Neck Squamous Cell Carcinoma",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2024-07-19",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06530914",
      "title": "A Phase II Study of MRG003 Injection Combined With Pucotenlimab Injection \u00b1 Cisplatin Injection in the Neoadjuvant Treatment Locally Advanced EGFR-positive Head and Neck Squamous Cell Carcinoma",
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      "last_update": "2024-07-31",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06647563",
      "title": "Neoadjuvant Toripalimab + Chemotherapy \u00b1 Cetuximab in Locally Advanced Head and Neck Squamous Cell Carcinoma (Neo-ICT)",
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      "last_update": "2024-10-18",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06728618",
      "title": "Preoperative Tislelizumab -Cetuximab - Chemotherapy Followed by Salvage Surgery and Adjuvant Tislelizumab -Cetuximab for Resectable, Locally Recurrent Oral and Oropharyngeal Squamous Cell Carcinoma",
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      "last_update": "2024-12-11",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06806852",
      "title": "A Study to Test Whether Treatment With BI 770371 in Combination With Pembrolizumab With or Without Cetuximab Helps People With Head and Neck Cancer Compared With Pembrolizumab Alone",
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      "last_update": "2026-09-02",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06855212",
      "title": "Phase II Study of Neoadjuvant Cetuximab and Cemiplimab in Patients Undergoing Surgery for HNSCC",
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      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06919666",
      "title": "NT219 Combined With Standard of Care Biologic Therapy in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma",
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      "last_update": "2026-07-02",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT07251062",
      "title": "A Study of SYS6010, Enlonstobart, and Chemotherapy for First-Line Treatment of Esophageal Squamous Cell Carcinoma.",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2025-11-26",
      "phase": "PHASE2/PHASE3",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT07279116",
      "title": "ABY-029 Head & Neck Trial",
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      "last_update": "2026-05-07",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT07320690",
      "title": "De-Escalation Surgery After Immunotherapy in Locally Advanced Head and Neck Squamous Cell Carcinoma",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2026-01-06",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT07509099",
      "title": "Cetuximab Combined With Pembrolizumab or Finotonlimab and Chemotherapy in R/M HNSCC",
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      "last_update": "2026-09-03",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT07529873",
      "title": "Phase II Study of Ficerafusp Alfa in Combination With Nivolumab in Patients With Platinum-refractory Head and Neck Squamous Cell Carcinoma",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2026-04-14",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT07589049",
      "title": "Becotatug Vedotin Combined With Pucotenlimab as Neoadjuvant Therapy for Resectable Recurrent Head and Neck Squamous Cell Carcinoma After Progression on Immunotherapy: A Prospective Phase II Study",
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     {
      "nct": "NCT07601204",
      "title": "Treatment of Recurrent/Metastatic Head and Neck Cancer",
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      "last_update": "2026-05-22",
      "phase": "PHASE1/PHASE2",
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     {
      "nct": "NCT07618624",
      "title": "BRIDGE Study: Neoadjuvant Finotonlimab, Cetuximab, and Docetaxel in Resectable Recurrent HNSCC After Immunotherapy Progression",
      "status": "ENROLLING_BY_INVITATION",
      "last_update": "2026-06-01",
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      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT07653451",
      "title": "Precision Medicine for Immunotherapy-Resistant Advanced Esophageal Cancer",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2026-06-17",
      "phase": "PHASE2/PHASE3",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT07683507",
      "title": "Becotatug Vedotin Plus PD-1 Inhibitor for Head and Neck Squamous Cell Carcinoma",
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      "last_update": "2026-07-06",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT07697040",
      "title": "Becotatug Vedotin Plus Cisplatin and Radiotherapy in LA-ESCC",
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      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT07741643",
      "title": "Study Evaluating the Safety and Feasibility of Panitumumab-IRDye800 and [18F]NOTA-ABY-030 for Targeted Dual-Modality Imaging (TDMI) in Head and Neck Squamous Cell Carcinoma",
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      "last_update": "2026-08-03",
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      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT07766889",
      "title": "Neoadjuvant Presurgical Becotatug Vedotin (MRG003) Plus Pucotenlimab (HX008) in Oral Cavity Squamous Cell Carcinoma",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2026-08-17",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07807956",
      "title": "A Study to Assess Adverse Events, Change in Disease Activity and How Intravenous ABBV-253 Moves Through the Body in Adult Participants With Advanced Solid Tumors",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2026-09-08",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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      {
       "nct": "NCT06682793",
       "title": "A Study to Evaluate the Safety and Efficacy of A2B395, an Allogeneic Logic-gated CAR T, in Participants With Solid Tumors That Express EGFR and Have Lost HLA-A*02 Expression",
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       "last_update": "2025-09-09",
       "phase": "PHASE1/PHASE2",
       "study_type": "INTERVENTIONAL"
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      {
       "nct": "NCT07617805",
       "title": "EGFR/HER2 Dual-Target CAR-NK Cells for Recurrent or Metastatic HNSCC",
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       "last_update": "2026-06-01",
       "phase": "PHASE1/PHASE2",
       "study_type": "INTERVENTIONAL"
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      {
       "nct": "NCT02507154",
       "title": "Reactivating NK Cells in Treating Refractory Head and Neck Cancer",
       "status": "UNKNOWN",
       "last_update": "2018-08-21",
       "phase": "PHASE1/PHASE2",
       "study_type": "INTERVENTIONAL"
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      {
       "nct": "NCT03645928",
       "title": "Study of Autologous Tumor Infiltrating Lymphocytes in Patients With Solid Tumors",
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      {
       "nct": "NCT04290546",
       "title": "CIML NK Cell in Head & Neck Cancer",
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       "study_type": "INTERVENTIONAL"
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      {
       "nct": "NCT04616196",
       "title": "Study of NKTR 255 in Combination With Cetuximab in Solid Tumors",
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       "last_update": "2025-06-08",
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      "nct": "NCT03556228",
      "title": "VMD-928 Monotherapy and in Combination With Pembrolizumab to Treat TrkA Overexpression Driven Solid Tumors or Lymphoma",
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      "phase": "PHASE1/PHASE2",
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     {
      "nct": "NCT03952065",
      "title": "IT or IA Infusion of PD1/PDL1/CTLA4 Inhibitors Versus IV for Immunotherapy of Head/Neck Cancers (HNC)",
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      "last_update": "2024-06-26",
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     {
      "nct": "NCT04198766",
      "title": "Study of INBRX-106 and INBRX-106 in Combination With Pembrolizumab (Keytruda\u00ae) in Subjects With Locally Advanced or Metastatic Solid Tumors (Hexavalent OX40 Agonist)",
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      "last_update": "2026-07-29",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT04273061",
      "title": "Investigating the Effects of Atezolizumab in People Whose Tumour DNA or RNA Indicates Possible Sensitivity",
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      "last_update": "2025-09-22",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT04481256",
      "title": "TGF-\u03b2 And PDL-1 Inhibition in Esophageal Squamous Cell Carcinoma Combined With Chemoradiation TheRapY",
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      "last_update": "2024-07-26",
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      "study_type": "INTERVENTIONAL"
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      "nct": "NCT04777994",
      "title": "Study With ABBV-CLS-484 in Participants With Locally Advanced or Metastatic Tumors",
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      "last_update": "2026-06-04",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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      "nct": "NCT04821778",
      "title": "Chemoradiotherapy in Esophageal or Esophagogastric Junction Cancer",
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      "last_update": "2026-01-21",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT04821843",
      "title": "Neoadjuvant Treatment Modalities in Esophageal Cancer",
      "status": "RECRUITING",
      "last_update": "2026-01-21",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT04954599",
      "title": "Phase 1/2 Clinical Trial of CP-506 (HAP) in Monotherapy or With Carboplatin or ICI",
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      "last_update": "2025-10-07",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT04999761",
      "title": "AB122 Platform Study",
      "status": "RECRUITING",
      "last_update": "2026-08-05",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT05187338",
      "title": "Triplex Checkpoint Inhibitors Therapy for Advanced Solid Tumors",
      "status": "RECRUITING",
      "last_update": "2024-06-25",
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      "nct": "NCT05267626",
      "title": "Study of AU-007, A Monoclonal Antibody That Binds to IL-2 and Inhibits IL-2R\u03b1 Binding, in Patients With Unresectable Locally Advanced or Metastatic Cancer",
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     {
      "nct": "NCT05319730",
      "title": "A Study to Evaluate Investigational Agents With or Without Pembrolizumab (MK-3475) in Participants With Advanced Esophageal Cancer Previously Exposed to Programmed Cell Death 1 Protein (PD-1)/ Programmed Cell Death Ligand 1 (PD-L1) Treatment (MK-3475-06B)",
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      "nct": "NCT05483400",
      "title": "Open Label Phase 2 Basket Trial With Atezolizumab and Tiragolumab in Solid Tumors",
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      "nct": "NCT05777824",
      "title": "Postoperative Management for HNSCC Based on Pathological Response of Induction Chemotherapy and Immunotherapy",
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      "phase": "PHASE2",
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     {
      "nct": "NCT05799144",
      "title": "pBI-11 & TA-HPV (With Pembrolizumab as Treatment for Patients w/Advanced, PD-L1 CPS\u22651, hrHPV+ Oropharyngeal Cancer",
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     {
      "nct": "NCT05877430",
      "title": "Safety, Tolerability, and Preliminary Efficacy of CJRB-101 With Pembrolizumab in Subjects With Selected Types of Advanced or Metastatic Cancer",
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     {
      "nct": "NCT05919030",
      "title": "A Study of Chemoradiation in Combination with Tislelizumab As First Line Treatment in Participants with Advanced Esophageal Squamous Cell Carcinoma",
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      "phase": "PHASE3",
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      "nct": "NCT05944237",
      "title": "HTL0039732 in Participants With Advanced Solid Tumours",
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     {
      "nct": "NCT06016920",
      "title": "Safety and Efficacy of VB10.16 and Pembrolizumab in Patients With Head-Neck Squamous Cell Carcinoma",
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      "phase": "PHASE1/PHASE2",
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     {
      "nct": "NCT06022029",
      "title": "A Dose Escalation and Dose Expansion Study of Intratumoral ONM-501 Alone and in Combination With Cemiplimab in Patients With Advanced Solid Tumors and Lymphomas.",
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      "last_update": "2025-12-24",
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     {
      "nct": "NCT06047379",
      "title": "Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis",
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      "last_update": "2026-07-16",
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     {
      "nct": "NCT06081673",
      "title": "Penpulimab Combined With Chemotherapy for Neoadjuvant and Adjuvant Therapy in Patients With Resectable HNSCC",
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      "last_update": "2023-10-13",
      "phase": "PHASE2",
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     {
      "nct": "NCT06161545",
      "title": "Pembrolizumab + N-803 Alone or in Combination With PD-L1 t-haNK Cells for Resectable Head and Neck Squamous Cell Carcinoma",
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      "last_update": "2026-08-24",
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     {
      "nct": "NCT06239220",
      "title": "PD-L1 t-haNK, NAI IL-15sa and Cetuximab for Recurrent, Metastatic HNSCC",
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      "last_update": "2026-08-18",
      "phase": "PHASE2",
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     {
      "nct": "NCT06254911",
      "title": "Pre-operative Atezolizumab in Patients With Resectable, Human Papillomavirus Related Oropharyngeal Carcinoma",
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      "last_update": "2026-08-05",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06259552",
      "title": "A Study of SPX-303, a Bispecific Antibody Targeting LILRB2 and PD-L1 in Patients With Solid Tumors",
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      "last_update": "2024-09-24",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06290505",
      "title": "A Trial of Palliative Chemotherapy, Radiation and Immune Treatment for Oesophageal Cancer: PALEO Study",
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      "last_update": "2026-05-08",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06332755",
      "title": "Study to Evaluate LB-LR1109, Administered Alone for the Treatment of Solid Tumor and in Combination With Atezolizumab for the Treatment of NSCLC",
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      "last_update": "2025-11-24",
      "phase": "PHASE1",
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     {
      "nct": "NCT06422403",
      "title": "A Value-Driven Study on Reducing Immune Checkpoint Inhibitor Dosing Frequency in Advanced Cancers",
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      "last_update": "2025-01-10",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06444815",
      "title": "A Study of VET3-TGI in Patients With Solid Tumors",
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      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06445972",
      "title": "Substudy 06D: Combination Therapies in Second Line (2L) Gastroesophageal Adenocarcinoma (MK-3475-06D/Keymaker-U06)",
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      "last_update": "2026-09-03",
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     {
      "nct": "NCT06469944",
      "title": "Substudy 06C: A Study of Investigational Agents With Pembrolizumab (MK-3475) and Chemotherapy in Participants With First-Line Locally Advanced Unresectable/Metastatic Gastroesophageal Adenocarcinoma (MK-3475-06C/KEYMAKER-U06)",
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     {
      "nct": "NCT06601335",
      "title": "A Phase 3 Study of AK112 Plus AK117 Versus Pembrolizumab in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma (R/M HNSCC)",
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      "last_update": "2024-11-14",
      "phase": "PHASE3",
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     {
      "nct": "NCT06675214",
      "title": "Under Whole-course of Immunotherapy, Gradient Fractionated RT with CCT Versus CFRT with CCT for LANPC Who Achieved PR Post Induction Chemotherapy.",
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      "last_update": "2024-11-05",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06788990",
      "title": "FORTIFI-HN01: A Study of Ficerafusp Alfa (BCA101) or Placebo in Combination With Pembrolizumab in First-Line PD-L1-pos, R or M HNSCC",
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      "last_update": "2026-07-17",
      "phase": "PHASE2/PHASE3",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06839066",
      "title": "A Phase II Study to Evaluate HLX43 in Subjects With Recurrent/Metastatic Nasopharyngeal Carcinoma Failed or Intolerance to Second-line Therapy",
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      "last_update": "2025-11-24",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06869473",
      "title": "Cetuximab Plus Platinum and Taxane-based Chemotherapy, Followed by Avelumab and Cetuximab, as First-line Treatment for Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma (HNSCC) Patients With a PD-L1 Combined Positive Score (CPS)\u22651\u226419.",
      "status": "RECRUITING",
      "last_update": "2025-03-14",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06953089",
      "title": "DB-1311 in Combination With BNT327 or DB-1305 in Advanced/Metastatic Solid Tumors",
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      "last_update": "2026-05-22",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07026474",
      "title": "Re-Radiochemotherapy and Pembrolizumab vs. Immuno(Chemo)Therapy for Locoregionally Recurrent PD-L1 Positive (CPS\u22651) HNSCC",
      "status": "RECRUITING",
      "last_update": "2026-09-10",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT07071103",
      "title": "Intestinal Low Dose Radiotherapy Combined With Immunotherapy in Immune-resistant Metastatic Malignant Solid Tumors",
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      "last_update": "2025-11-20",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07105592",
      "title": "A Study of Nimotuzumab Plus Adebrelimab With Chemotherapy in Cisplatin-Ineligible Patients With Head And Neck Squamous Cell Carcinoma",
      "status": "RECRUITING",
      "last_update": "2025-08-06",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07195734",
      "title": "Testing the Addition of Chemotherapy or Chemo-Immunotherapy to the Usual Surgery for Advanced Head and Neck Cancer",
      "status": "RECRUITING",
      "last_update": "2026-09-11",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07213934",
      "title": "Phase I/ II Trial Combining PD-1 Inhibition and Neoadjuvant Proton or Photon Radiation Therapy in Recurrent Head and Neck Squamous Cell Carcinoma",
      "status": "RECRUITING",
      "last_update": "2026-07-01",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07222657",
      "title": "Liquid Nitrogen Spray Cryotherapy Prior to Neoadjuvant Systemic Therapy in Esophageal Adenocarcinoma",
      "status": "RECRUITING",
      "last_update": "2026-08-18",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07339488",
      "title": "Intestinal Low-Dose Radiotherapy Plus Immunochemotherapy for Conversion of Borderline Resectable/Unresectable Esophageal Squamous Cell Carcinoma",
      "status": "RECRUITING",
      "last_update": "2026-06-18",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07385001",
      "title": "A Prospective, Multicenter, Phase Ib/II Trial of Ivonescimab (AK112) Combined With Albumin-Paclitaxel and Cisplatin as Neoadjuvant Therapy for ESCC",
      "status": "RECRUITING",
      "last_update": "2026-02-03",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07431281",
      "title": "Sonesitatug Vedotin in Combination With Capecitabine With or Without Rilvegostomig in Participants With Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma Expressing Claudin18.2",
      "status": "RECRUITING",
      "last_update": "2026-09-09",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07700420",
      "title": "Perioperative FLOT(D) With Personalized Ultrafractionated Stereotactic Adaptive Radiotherapy (PULSAR) in Esophageal Cancer",
      "status": "RECRUITING",
      "last_update": "2026-09-02",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07781358",
      "title": "Becotatug Vedotin Combined With a PD-1 Inhibitor in the Treatment of Locally Advanced Recurrent Nasopharyngeal Carcinoma.",
      "status": "RECRUITING",
      "last_update": "2026-08-24",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07814287",
      "title": "Becotatug Vedotin Plus Pucotenlimab and Platinum Chemotherapy in Locally Advanced Epidermal Growth Factor Receptor (EGFR)-Positive Head and Neck Squamous Cell Carcinoma",
      "status": "RECRUITING",
      "last_update": "2026-09-10",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01772004",
      "title": "Avelumab in Metastatic or Locally Advanced Solid Tumors (JAVELIN Solid Tumor)",
      "status": "COMPLETED",
      "last_update": "2021-12-20",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01810913",
      "title": "Testing Docetaxel-Cetuximab or the Addition of an Immunotherapy Drug, Atezolizumab, to the Usual Chemotherapy and Radiation Therapy in High-Risk Head and Neck Cancer",
      "status": "SUSPENDED",
      "last_update": "2026-09-01",
      "phase": "PHASE2/PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01938612",
      "title": "A Phase I, Open-Label, Multicentre Study to Evaluate the Safety, Tolerability and Pharmacokinetics of MEDI4736 in Patients With Advanced Solid Tumours",
      "status": "COMPLETED",
      "last_update": "2021-03-12",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02207530",
      "title": "Phase II Study of MEDI4736 Monotherapy in Treatment of Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck",
      "status": "COMPLETED",
      "last_update": "2020-09-29",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02252042",
      "title": "Pembrolizumab (MK-3475) Versus Standard Treatment for Recurrent or Metastatic Head and Neck Cancer (MK-3475-040/KEYNOTE-040)",
      "status": "COMPLETED",
      "last_update": "2023-07-17",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02262741",
      "title": "A Phase I Study to Evaluate the Safety, Tolerability and Efficacy of MEDI4736 (Durvalumab) With Tremelimumab in Head and Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2017-10-23",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02264678",
      "title": "Ascending Doses of Ceralasertib in Combination With Chemotherapy and/or Novel Anti Cancer Agents",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-07-24",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02291055",
      "title": "A Study of ADXS11-001 or MEDI4736 Alone or Combination In Cervical or Human Papillomavirus (HPV)+ Head & Neck Cancer",
      "status": "TERMINATED",
      "last_update": "2023-03-20",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02318277",
      "title": "A Study of Epacadostat (INCB024360) in Combination With Durvalumab (MEDI4736) in Subjects With Selected Advanced Solid Tumors (ECHO-203)",
      "status": "COMPLETED",
      "last_update": "2022-01-13",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02319044",
      "title": "Phase II Study of MEDI4736, Tremelimumab, and MEDI4736 in Combination w/ Tremelimumab Squamous Cell Carcinoma of the Head and Neck",
      "status": "COMPLETED",
      "last_update": "2020-09-29",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02358031",
      "title": "A Study of Pembrolizumab (MK-3475) for First Line Treatment of Recurrent or Metastatic Squamous Cell Cancer of the Head and Neck (MK-3475-048/KEYNOTE-048)",
      "status": "COMPLETED",
      "last_update": "2025-07-18",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02369874",
      "title": "Study of MEDI4736 Monotherapy and in Combination With Tremelimumab Versus Standard of Care Therapy in Patients With Head and Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2021-02-10",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02423863",
      "title": "In Situ, Autologous Therapeutic Vaccination Against Solid Cancers With Intratumoral Hiltonol\u00ae",
      "status": "COMPLETED",
      "last_update": "2020-12-17",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02499328",
      "title": "Study to Assess MEDI4736 With Either AZD9150 or AZD5069 in Advanced Solid Tumors & Relapsed Metastatic Squamous Cell Carcinoma of Head & Neck",
      "status": "COMPLETED",
      "last_update": "2026-02-11",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02520453",
      "title": "Adjuvant Durvalumab for Esophageal Cancer",
      "status": "UNKNOWN",
      "last_update": "2019-12-09",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02543645",
      "title": "A Study of Varlilumab and Atezolizumab in Patients With Advanced Cancer",
      "status": "TERMINATED",
      "last_update": "2018-04-30",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02551159",
      "title": "Phase III Open Label Study of MEDI 4736 With/Without Tremelimumab Versus Standard of Care (SOC) in Recurrent/Metastatic Head and Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2021-10-13",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02554812",
      "title": "A Study Of Avelumab In Combination With Other Cancer Immunotherapies In Advanced Malignancies (JAVELIN Medley)",
      "status": "TERMINATED",
      "last_update": "2024-07-30",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02559687",
      "title": "Study of Pembrolizumab (MK-3475) in Previously-Treated Participants With Advanced Carcinoma of the Esophagus or Esophagogastric Junction (MK-3475-180/KEYNOTE-180)",
      "status": "COMPLETED",
      "last_update": "2022-09-14",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02564263",
      "title": "Study of Pembrolizumab (MK-3475) Versus Investigator's Choice Standard Therapy for Participants With Advanced Esophageal/ Esophagogastric Junction Carcinoma That Progressed After First-Line Therapy (MK-3475-181/KEYNOTE-181)",
      "status": "COMPLETED",
      "last_update": "2023-03-13",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02586987",
      "title": "A Study to Assess the Safety, Tolerability and Anti-tumour Activity of Ascending Doses of Selumetinib in Combination With MEDI4736 and Selumetinib in Combination With MEDI4736 and Tremelimumab in Patients With Advanced Solid Tumours",
      "status": "COMPLETED",
      "last_update": "2019-11-18",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02639065",
      "title": "A Study of Durvalumab (MEDI4736) in Esophageal Cancer",
      "status": "COMPLETED",
      "last_update": "2023-09-25",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02643303",
      "title": "A Study of Tremelimumab and IV Durvalumab Plus Poly-ICLC in Subjects With Biopsy-accessible Cancers",
      "status": "COMPLETED",
      "last_update": "2022-12-02",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02644369",
      "title": "Study of the Effects of Pembrolizumab in Patients With Advanced Solid Tumors",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-06-08",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02658214",
      "title": "Durvalumab and Tremelimumab in Combination With First-Line Chemotherapy in Advanced Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2020-08-20",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02735239",
      "title": "Study of Anti-PD-L1 in Combination With Chemo(Radio)Therapy for Oesophageal Cancer",
      "status": "COMPLETED",
      "last_update": "2024-03-22",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02827838",
      "title": "Durvalumab Before Surgery in Treating Patients With Oral Cavity or Oropharynx Cancer",
      "status": "TERMINATED",
      "last_update": "2025-03-17",
      "phase": "EARLY_PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02842125",
      "title": "Safety and Efficacy of Intra-Arterial and Intra-Tumoral Ad-p53 With Capecitabine (Xeloda) or Anti-PD-1 in Liver Metastases of Solid Tumors and Recurrent Head and Neck Squamous Cell Cancer",
      "status": "TERMINATED",
      "last_update": "2020-06-02",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02876510",
      "title": "ACTolog in Patients With Solid Cancers",
      "status": "COMPLETED",
      "last_update": "2025-02-04",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02882308",
      "title": "Preoperative Administration of Olaparib With Cisplatin or With Durvalumab or Alone or no Tratment in Patients Who Are Candidates for Surgery of Carcinoma of the Head and Neck.",
      "status": "COMPLETED",
      "last_update": "2020-02-07",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02903914",
      "title": "Arginase Inhibitor INCB001158 as a Single Agent and in Combination With Immune Checkpoint Therapy in Patients With Advanced/Metastatic Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2025-08-05",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02952989",
      "title": "A Safety Study of SGN-2FF for Patients With Advanced Solid Tumors",
      "status": "TERMINATED",
      "last_update": "2019-07-19",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02955290",
      "title": "CIMAvax Vaccine, Nivolumab, and Pembrolizumab in Treating Patients With Advanced Non-small Cell Lung Cancer or Squamous Head and Neck Cancer",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-08-10",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02993991",
      "title": "Pre-operative Mocetinostat (MGCD0103) and Durvalumab (MEDI4736) (PRIMED) for Squamous Cell Carcinoma of the Oral Cavity",
      "status": "WITHDRAWN",
      "last_update": "2017-12-29",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02997332",
      "title": "Durvalumab in Combination With Docetaxel, Cisplatin and 5-FU for Locally Advanced Head and Neck Squamous Cell Carcinoma",
      "status": "TERMINATED",
      "last_update": "2026-03-23",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03019003",
      "title": "Oral Decitabine (ASTX727) and Durvalumab in Recurrent and/or Metastatic Head and Neck Cancer Patients",
      "status": "COMPLETED",
      "last_update": "2025-09-16",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03040999",
      "title": "Study of Pembrolizumab (MK-3475) or Placebo With Chemoradiation in Participants With Locally Advanced Head and Neck Squamous Cell Carcinoma (MK-3475-412/KEYNOTE-412)",
      "status": "COMPLETED",
      "last_update": "2026-02-04",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03051906",
      "title": "Durvalumab, Cetuximab and Radiotherapy in Head Neck Cancer",
      "status": "UNKNOWN",
      "last_update": "2017-11-22",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03074513",
      "title": "Atezolizumab and Bevacizumab in Treating Patients With Rare Solid Tumors",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-03-11",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03087864",
      "title": "PDL-1 Targeting in Resectable Oesophageal Cancer",
      "status": "COMPLETED",
      "last_update": "2020-05-11",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03088059",
      "title": "Biomarker-based Study in R/M SCCHN",
      "status": "UNKNOWN",
      "last_update": "2023-11-03",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03126110",
      "title": "Phase 1/2 Study Exploring the Safety, Tolerability, and Efficacy of INCAGN01876 Combined With Immune Therapies in Advanced or Metastatic Malignancies",
      "status": "COMPLETED",
      "last_update": "2025-08-14",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03144778",
      "title": "Durvalumab With or Without Tremelimumab in Treating Participants With Stage II-IVA Oropharyngeal Squamous Cell Cancer",
      "status": "COMPLETED",
      "last_update": "2021-03-18",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03162224",
      "title": "Safety and Efficacy of MEDI0457 and Durvalumab in Participants With Human Papilloma Virus (HPV) Associated Recurrent/Metastatic Head and Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2022-08-25",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03170960",
      "title": "Study of Cabozantinib Alone or in Combination With Atezolizumab to Subjects With Locally Advanced or Metastatic Solid Tumors",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-08-17",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03174275",
      "title": "Carboplatin, Nab-Paclitaxel, Durvalumab Before Surgery and Adjuvant Therapy in Head and Neck Squamous Cell Carcinoma",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-02-23",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03181100",
      "title": "Atezolizumab With Chemotherapy in Treating Patients With Anaplastic or Poorly Differentiated Thyroid Cancer",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-07-24",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03189719",
      "title": "First-line Esophageal Carcinoma Study With Pembrolizumab Plus Chemo vs. Chemo (MK-3475-590/KEYNOTE-590)",
      "status": "COMPLETED",
      "last_update": "2024-10-15",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03212404",
      "title": "Phase 1 Study of CK-301 (Cosibelimab) as a Single Agent in Subjects With Advanced Cancers",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-02-03",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03212469",
      "title": "A Trial of Durvalumab and Tremelimumab in Combination With SBRT in Patients With Metastatic Cancer",
      "status": "COMPLETED",
      "last_update": "2025-05-08",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03215095",
      "title": "RAI Plus Immunotherapy for Recurrent/Metastatic Thyroid Cancers",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-08-11",
      "phase": "EARLY_PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03228667",
      "title": "QUILT-3.055: A Study of Combination Immunotherapies in Patients Who Have Previously Received Treatment With Immune Checkpoint Inhibitors",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-01-14",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03238638",
      "title": "A Study of Epacadostat + Pembrolizumab in Head and Neck Cancer Patients, Who Failed Prior PD-1/PD-L1 Therapy",
      "status": "WITHDRAWN",
      "last_update": "2018-01-04",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03241173",
      "title": "A Study Exploring the Safety and Efficacy of INCAGN01949 in Combination With Immune Therapies in Advanced or Metastatic Malignancies",
      "status": "COMPLETED",
      "last_update": "2022-09-27",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03258554",
      "title": "Radiation Therapy With Durvalumab or Cetuximab in Treating Patients With Locoregionally Advanced Head and Neck Cancer Who Cannot Take Cisplatin",
      "status": "COMPLETED",
      "last_update": "2026-08-27",
      "phase": "PHASE2/PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03281369",
      "title": "A Study of Multiple Immunotherapy-Based Treatment Combinations in Patients With Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction Cancer (G/GEJ) or Esophageal Cancer (Morpheus-Gastric and Esophageal Cancer)",
      "status": "TERMINATED",
      "last_update": "2026-08-03",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03283605",
      "title": "Immunotherapy and SBRT for Metastatic Head and Neck Carcinomas",
      "status": "COMPLETED",
      "last_update": "2026-08-14",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03289962",
      "title": "A Study of Autogene Cevumeran (RO7198457) as a Single Agent and in Combination With Atezolizumab in Participants With Locally Advanced or Metastatic Tumors",
      "status": "COMPLETED",
      "last_update": "2026-06-08",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03292250",
      "title": "Korean Cancer Study Group: Translational bIomarker Driven UMbrella Project for Head and Neck (TRIUMPH), Esophageal Squamous Cell Carcinoma- Part 1 (HNSCC)]",
      "status": "COMPLETED",
      "last_update": "2022-03-29",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03313804",
      "title": "Priming Immunotherapy in Advanced Disease With Radiation",
      "status": "COMPLETED",
      "last_update": "2026-03-11",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03347838",
      "title": "Nivolumab for the Reversal of Squamous Dysplasia in High Risk Current and Former Smokers",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-12-12",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03377400",
      "title": "Definitive CCRT Combined With Durvalumab and Tremelimumab for Inoperable Esophageal Cancer",
      "status": "UNKNOWN",
      "last_update": "2020-12-17",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03381183",
      "title": "IRX-2 Regimen and Durvalumab, for Incurable H&N Squamous Cell Carcinoma",
      "status": "COMPLETED",
      "last_update": "2025-12-05",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03386721",
      "title": "Basket Study to Evaluate the Therapeutic Activity of Simlukafusp Alfa as a Combination Therapy in Participants With Advanced and/or Metastatic Solid Tumors",
      "status": "TERMINATED",
      "last_update": "2023-02-21",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03399071",
      "title": "Study Title: Peri-operative Immuno-Chemotherapy in Operable Oesophageal and Gastric Cancer",
      "status": "UNKNOWN",
      "last_update": "2023-02-21",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03410615",
      "title": "Cisplatin + Radiotherapy vs Durvalumab + Radiotherapy Followed by Durvalumab vs Durvalumab + Radiotherapy Followed by Tremelimumab + Durvalumab in Intermediate-Risk HPV-Positive Oropharyngeal SCC",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-03-24",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03412058",
      "title": "Identifying the Predictive Factors of Response to PD-1 or PD-L1 Antagonists",
      "status": "TERMINATED",
      "last_update": "2026-08-03",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03450967",
      "title": "Durvalumab Plus Tremelimumab Combined With Proton Therapy for HNSCC",
      "status": "UNKNOWN",
      "last_update": "2021-08-10",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03463161",
      "title": "Epacadostat and Pembrolizumab in Patients With Head and Neck Cancer That Have Failed Prior Immunotherapy",
      "status": "TERMINATED",
      "last_update": "2020-01-27",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03474497",
      "title": "UCDCC#272: IL-2, Radiotherapy, and Pembrolizumab in Patients Refractory to Checkpoint Blockade",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-01-29",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03509012",
      "title": "Immunotherapy in Combination With Chemoradiation in Patients With Advanced Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2025-01-14",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03511391",
      "title": "CHEckpoint Inhibition in Combination With an Immunoboost of External Beam Radiotherapy in Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2024-01-23",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03518606",
      "title": "Metronomic Oral Vinorelbine Plus Anti-PD-L1/Anti-CTLA4 ImmunothErapy in Patients With Advanced Solid Tumours",
      "status": "COMPLETED",
      "last_update": "2025-01-15",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03522584",
      "title": "Durvalumab, Tremelimumab and Hypofractionated Radiation Therapy in Treating Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma",
      "status": "TERMINATED",
      "last_update": "2023-06-12",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03529422",
      "title": "Durvalumab With Radiotherapy for Adjuvant Treatment of Intermediate Risk SCCHN",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-06-23",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03544723",
      "title": "Safety and Efficacy of p53 Gene Therapy Combined With Immune Checkpoint Inhibitors in Solid Tumors.",
      "status": "UNKNOWN",
      "last_update": "2020-06-09",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03575598",
      "title": "Sitravatinib (MGCD516) and Nivolumab in Oral Cavity Cancer Window Opportunity Study",
      "status": "COMPLETED",
      "last_update": "2023-07-27",
      "phase": "EARLY_PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03618134",
      "title": "Stereotactic Body Radiation Therapy and Durvalumab With or Without Tremelimumab Before Surgery in Treating Participants With Human Papillomavirus Positive Oropharyngeal Squamous Cell Caner",
      "status": "TERMINATED",
      "last_update": "2023-11-18",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03618654",
      "title": "Durvalumab With or Without Metformin in Treating Participants With Head and Neck Squamous Cell Carcinoma",
      "status": "COMPLETED",
      "last_update": "2025-05-15",
      "phase": "EARLY_PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03623646",
      "title": "Cisplatin or ImmunoTHerapy in Association With Definitive Radiotherapy in HPV-related oropharyngEal Squamous Cell Carcinoma: a Randomized Phase II Trial.",
      "status": "COMPLETED",
      "last_update": "2025-08-08",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03624231",
      "title": "Feasibility & Efficacy of Durvalumab+Tremelimumab+RT and Durvalumab+RT in Non-resect. Locally Advanced HPVnegativ HNSCC",
      "status": "COMPLETED",
      "last_update": "2023-08-31",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03635164",
      "title": "Radiotherapy With Durvalumab Prior to Surgical Resection for HPV Negative Squamous Cell Carcinoma",
      "status": "COMPLETED",
      "last_update": "2025-06-27",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03653052",
      "title": "Do Changes in ctDNA Predict Response for Patients With Oesophageal Cancer Receiving Durvalumab",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-04-24",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03665285",
      "title": "A Safety and Tolerability Study of NC318 in Subjects With Advanced or Metastatic Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2024-03-08",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03666273",
      "title": "Phase 1 Study of BAY1905254 - An Early Clinical Research Study to Evaluate a New Drug Called Bapotulimab (BAY1905254) in the Expansion Cohort in Combination With Pembrolizumab in Head and Neck Cancer That Has Returned or is Discovered to be Metastatic and is Expressing PDL1.",
      "status": "COMPLETED",
      "last_update": "2024-05-28",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03673735",
      "title": "Maintenance Immune Check-point Inhibitor Following Post-operative Chemo-radiation in Subjects With HPV-negative HNSCC",
      "status": "WITHDRAWN",
      "last_update": "2021-05-10",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03684785",
      "title": "Intratumoral Cavrotolimod Combined With Pembrolizumab or Cemiplimab in Patients With Merkel Cell Carcinoma, Cutaneous Squamous Cell Carcinoma, or Other Advanced Solid Tumors",
      "status": "TERMINATED",
      "last_update": "2022-04-07",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03691714",
      "title": "Durvalumab (MEDI4736) With Cetuximab in Previously Treated Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma",
      "status": "COMPLETED",
      "last_update": "2026-09-02",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03693014",
      "title": "A Study of Several Radiation Doses for Patients With Progression on Immunotherapy/Checkpoint Inhibitors",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-07-24",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03693612",
      "title": "GSK3359609 Plus Tremelimumab for the Treatment of Advanced Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2024-08-28",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03708224",
      "title": "Preoperative Immunotherapy in Patients With Squamous Cell Carcinoma of the Head and Neck",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-08-11",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03708328",
      "title": "A Dose Escalation and Expansion Study of Lomvastomig, a PD-1/TIM-3 Bispecific Antibody, in Participants With Advanced and/or Metastatic Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2025-08-20",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03723967",
      "title": "FRAIL-IMMUNE (GORTEC 2018-03) - Combination of Durvalumab With Carboplatin/Paclitaxel",
      "status": "COMPLETED",
      "last_update": "2024-04-22",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03726775",
      "title": "Trial Evaluating the Tolerance and Safety of Durvalumab - RT Combination for Treatment in SCCHN",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-05-07",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03737968",
      "title": "Window of Opportunity Trial of Durvalumab (MEDI4736) or Durvalumab/Tremelimumab as Neoadjuvant Chemotherapy to Identify Immune Dynamics in Surgically Resectable Head and Neck Cancer Patients.",
      "status": "UNKNOWN",
      "last_update": "2023-03-21",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03739931",
      "title": "Dose Escalation Study of mRNA-2752 for Intratumoral Injection to Participants in Advanced Malignancies",
      "status": "COMPLETED",
      "last_update": "2025-08-15",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03753919",
      "title": "Durvalumab Plus Tremelimumab for the Treatment of Patients With Progressive, Refractory Advanced Thyroid Carcinoma -The DUTHY Trial",
      "status": "TERMINATED",
      "last_update": "2026-03-11",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03764553",
      "title": "Liposomal iRInotecan, Carboplatin or oXaliplatin for Esophagogastric Cancer",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-08-21",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03765918",
      "title": "Study of Pembrolizumab Given Prior to Surgery and in Combination With Radiotherapy Given Post-surgery for Advanced Head and Neck Squamous Cell Carcinoma (MK-3475-689)",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-07-31",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03769467",
      "title": "Tabelecleucel in Combination With Pembrolizumab in Subjects With Epstein-Barr Virus-associated Nasopharyngeal Carcinoma (EBV+ NPC)",
      "status": "TERMINATED",
      "last_update": "2024-11-14",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03777813",
      "title": "Association of Radiochemotherapy and Immunotherapy for the Treatment of Unresectable Oesophageal caNcer",
      "status": "COMPLETED",
      "last_update": "2025-11-18",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03784066",
      "title": "Durvalumab With or Without Tremelimumab in Resectable Locally Advanced Squamous Cell Carcinoma of the Oral Cavity",
      "status": "UNKNOWN",
      "last_update": "2024-07-03",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03799744",
      "title": "Safety,Tolerability,and Efficacy of VCN-01 With Durvalumab in R/M Head and Neck Squamous Cell Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2022-03-28",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03809624",
      "title": "Study of INBRX-105 and INBRX-105 With Pembrolizumab in Patients With Solid Tumors Including Head and Neck Cancer",
      "status": "TERMINATED",
      "last_update": "2024-10-23",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03811652",
      "title": "A Multiple Ascending Dose Study of MEDI7247 in Advanced or Metastatic Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2019-12-30",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03818061",
      "title": "Atezolizumab and Bevacizumab in Patients With Recurrent or Metastatic Squamous-cell Carcinoma of the Head and Neck",
      "status": "COMPLETED",
      "last_update": "2026-04-24",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03818997",
      "title": "Combination of Targeted and Immunotherapy for Advanced Biliary Tract and Esophagogastric Gastric Cancer",
      "status": "WITHDRAWN",
      "last_update": "2020-02-05",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03821935",
      "title": "Study to Determine the Safety, Tolerability, Pharmacokinetics and Recommended Phase 2 Dose (RP2D) of Livmoniplimab (ABBV-151) as a Single Agent and in Combination With Budigalimab (ABBV-181) in Participants With Locally Advanced or Metastatic Solid Tumors",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-05-25",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03829007",
      "title": "PD-L1 ImagiNg to prediCt Durvalumab Treatment Response in HNSCC",
      "status": "COMPLETED",
      "last_update": "2022-01-10",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03829501",
      "title": "A Phase 1/2, Open-label, Multi-center Study of the Safety and Efficacy of Alomfilimab (KY1044) as Single Agent and in Combination With Anti-PD-L1 (Atezolizumab) in Adult Patients With Selected Advanced Malignancies",
      "status": "TERMINATED",
      "last_update": "2025-04-02",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03841110",
      "title": "FT500 as Monotherapy and in Combination With Immune Checkpoint Inhibitors in Subjects With Advanced Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2023-05-01",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03843515",
      "title": "Neoadjuvant Nivolumab for Oral Cancer Combined With FDG and Anti-PD-L1 PET/CT Imaging for Response Prediction",
      "status": "UNKNOWN",
      "last_update": "2021-10-08",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03844763",
      "title": "Targeting the Tumor Microenvironment in R/M SCCHN",
      "status": "UNKNOWN",
      "last_update": "2020-03-03",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03861793",
      "title": "A Dose Escalation and Cohort Expansion Study of Subcutaneously-Administered Cytokine ALKS 4230 (Nemvaleukin Alfa) as a Single Agent and in Combination With Anti-PD-1 Antibody (Pembrolizumab) in Subjects With Select Advanced or Metastatic Solid Tumors (ARTISTRY-2)",
      "status": "COMPLETED",
      "last_update": "2024-03-05",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03881111",
      "title": "First-line Esophageal Carcinoma Study With Chemo vs. Chemo Plus Pembrolizumab (MK-3475-590/KEYNOTE-590)-China Extension Study",
      "status": "WITHDRAWN",
      "last_update": "2020-02-11",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03933449",
      "title": "Study of Pembrolizumab (MK-3475) Versus Investigator's Choice of Chemotherapy for Participants With Advanced Esophageal/Esophagogastric Junction Carcinoma That Progressed After First-Line Therapy (MK-3475-181/KEYNOTE-181)-China Extension Study",
      "status": "COMPLETED",
      "last_update": "2023-03-29",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03946358",
      "title": "Combination of UCPVax Vaccine and Atezolizumab for the Treatment of Human Papillomavirus Positive Cancers (VolATIL)",
      "status": "COMPLETED",
      "last_update": "2024-12-20",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03983954",
      "title": "Naptumomab Estafenatox in Combination With Durvalumab in Subjects With Selected Advanced or Metastatic Solid Tumor, Including a Cohort Expansion in Esophageal Cancer.",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-11-28",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04001413",
      "title": "Therapy for High-Risk HPV 16-Positive Oropharynx Cancer Patients",
      "status": "WITHDRAWN",
      "last_update": "2022-07-29",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04052204",
      "title": "Avelumab With Bempegaldesleukin With or Without Talazoparib or Enzalutamide in Advanced or Metastatic Solid Tumors",
      "status": "TERMINATED",
      "last_update": "2021-10-14",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04054518",
      "title": "Durvalumab as Maintenance Following Chemoradiation for Unresectable Esophageal Squamous Cell Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2019-08-13",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04060342",
      "title": "GB1275 Monotherapy and in Combination With an Anti-PD1 Antibody in Patients With Specified Advanced Solid Tumors or in Combination With Standard of Care in Patients With Metastatic Pancreatic Adenocarcinoma",
      "status": "TERMINATED",
      "last_update": "2022-08-18",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04084951",
      "title": "Study of SQZ-PBMC-HPV in Patients With HPV16+ Recurrent, Locally Advanced or Metastatic Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2023-04-14",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04096638",
      "title": "Safety and Efficacy of SB 11285 Alone and in Combination With Atezolizumab in Patients With Advanced Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2024-10-31",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04116047",
      "title": "CompARE: Escalating Treatment of Intermediate and High-risk Oropharyngeal Cancer (OPC)",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-05-07",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04116320",
      "title": "Focused Ultrasound Ablation and PD-1 Antibody Blockade in Advanced Solid Tumors",
      "status": "TERMINATED",
      "last_update": "2025-07-14",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04144517",
      "title": "A Study of ALKS 4230 (Nemvaleukin Alfa) With Pembrolizumab in Head and Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2024-10-16",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04150900",
      "title": "1922GCCC: Pembro and Bavituximab for Squamous Cell Carcinoma of Head and Neck",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-02-19",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04157985",
      "title": "Evaluating Length of Treatment With PD-1/PD-L1 Inhibitor in Advanced Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2025-12-11",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04166721",
      "title": "WaKING: Wnt and checKpoint INhibition in Gastric Cancer",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-04-06",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04199104",
      "title": "A Study of Pembrolizumab (MK-3475) With or Without Lenvatinib (E7080/MK-7902) as First Line (1L) Intervention in a Programmed Cell Death-ligand 1 (PD-L1) Selected Population With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma (R/M HNSCC) (MK-7902-010) (KEYNOTE-010)",
      "status": "COMPLETED",
      "last_update": "2026-05-05",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04210115",
      "title": "Study of Pembrolizumab (MK-3475) Versus Placebo in Participants With Esophageal Carcinoma Who Are Receiving Chemotherapy and Radiation Therapy (MK-3475-975/KEYNOTE-975)",
      "status": "COMPLETED",
      "last_update": "2026-07-22",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04215471",
      "title": "NeoAdjuvant Therapy With Immunoreagent (SHR-1316) for Resectable Oesophageal Squamous Cell carciNoma",
      "status": "UNKNOWN",
      "last_update": "2022-06-14",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04220775",
      "title": "Bintrafusp Alfa and Stereotactic Body Radiation Therapy for the Treatment of Recurrent or Second Primary Head and Neck Squamous Cell Cancer",
      "status": "TERMINATED",
      "last_update": "2024-11-07",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04220866",
      "title": "Study of Intratumoral (IT) Ulevostinag (MK-1454) in Combination With Intravenous (IV) Pembrolizumab (MK-3475) Compared to IV Pembrolizumab Alone as the First Line Treatment of Metastatic or Unresectable, Recurrent Head and Neck Squamous Cell Carcinoma (HNSCC) (MK-1454-002)",
      "status": "COMPLETED",
      "last_update": "2025-10-29",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04231864",
      "title": "Durvalumab and Epacadostat for Treatment of Unresectable, Recurrent, or Metastatic Epstein-Barr Virus Positive Nasopharyngeal Cancer",
      "status": "WITHDRAWN",
      "last_update": "2020-10-26",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04244552",
      "title": "A Phase 1b Trial of ATRC-101 in Adults With Advanced Solid Malignancies",
      "status": "TERMINATED",
      "last_update": "2023-12-29",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04247282",
      "title": "Anti-PD-L1/TGF-beta Trap (M7824) Alone and in Combination With TriAd Vaccine and N-803 for Resectable Head and Neck Squamous Cell Carcinoma Not Associated With Human Papillomavirus Infection",
      "status": "COMPLETED",
      "last_update": "2025-07-16",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04260802",
      "title": "A Study to Evaluate the Safety and Pharmacokinetics of OC-001 in Patients With Locally Advanced or Metastatic Cancers",
      "status": "TERMINATED",
      "last_update": "2026-01-12",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04262388",
      "title": "A Multi-Cancer, Multi-State, Platform Study of Durvalumab (MEDI4736) and Oleclumab (MEDI9447) in Pancreatic Adenocarcinoma, Non-Small Cell Lung Cancer and Squamous Cell Carcinoma of the Head and Neck to Correlate Clinical, Molecular and Immunologic Parameters With DNA Methylation",
      "status": "WITHDRAWN",
      "last_update": "2020-11-17",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04282070",
      "title": "SHR-1701 in Patients With Recurrent/Metastatic Nasopharyngeal Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2021-12-21",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04291079",
      "title": "SRK-181 Alone or in Combination With Anti-PD-(L)1 Antibody Therapy in Patients With Locally Advanced or Metastatic Solid Tumors (DRAGON)",
      "status": "COMPLETED",
      "last_update": "2025-04-29",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04326257",
      "title": "Personalized Immunotherapy in Patients With Recurrent /Metastatic SCCHN That Have Progressed on Prior Immunotherapy",
      "status": "COMPLETED",
      "last_update": "2026-01-08",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04338399",
      "title": "The BURAN Study of Buparlisib in Patients With Recurrent or Metastatic HNSCC",
      "status": "COMPLETED",
      "last_update": "2025-11-17",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04369937",
      "title": "HPV-16 Vaccination and Pembrolizumab Plus Cisplatin for \"Intermediate Risk\" HPV-16-associated Head and Neck Squamous Cell Carcinoma",
      "status": "COMPLETED",
      "last_update": "2026-05-13",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04379596",
      "title": "Ph1b/2 Study of the Safety and Efficacy of T-DXd Combinations in Advanced HER2-expressing Gastric Cancer (DESTINY-Gastric03)",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-08-28",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04428047",
      "title": "Evaluation of Bintrafusp Alfa in Operable and Untreated Head and Neck Squamous Cell Carcinoma",
      "status": "TERMINATED",
      "last_update": "2022-04-06",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04428151",
      "title": "Lenvatinib (E7080/MK-7902) in Combination With Pembrolizumab (MK-3475) vs. Standard Chemotherapy and Lenvatinib Monotherapy in Participants With Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma That Progressed After Platinum Therapy and Immunotherapy (MK-7902-009/E7080-G000-228/LEAP-009)",
      "status": "COMPLETED",
      "last_update": "2025-12-04",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04432597",
      "title": "HPV Vaccine PRGN-2009 Alone or in Combination With Anti-PDL1/TGF-Beta Trap (M7824) in Subjects With HPV Associated Cancers",
      "status": "COMPLETED",
      "last_update": "2026-08-18",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04442126",
      "title": "A Study of NM21-1480 in Adult Patients With Advanced Solid Tumors",
      "status": "TERMINATED",
      "last_update": "2025-05-23",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04447612",
      "title": "Concurrent Chemoradiation and Durvalumab for Locoregionally Advanced Nasopharyngeal Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2020-06-25",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04460066",
      "title": "A Study of Anti-PD-L1 Antibody in Neoadjuvant Chemotherapy of Esophageal Squamous Cell Carcinoma.",
      "status": "UNKNOWN",
      "last_update": "2022-05-04",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04477759",
      "title": "Dose-Escalated Hypofractionated Adaptive Radiotherapy for Head and Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2026-08-20",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04489888",
      "title": "A Study of Pembrolizumab (MK-3475) Plus Carboplatin and Paclitaxel as First-line Treatment of Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma (MK-3475-B10/KEYNOTE B10)",
      "status": "COMPLETED",
      "last_update": "2025-06-19",
      "phase": "PHASE4",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04494009",
      "title": "PD-1 Inhibitor INCMGA00012 as Consolidation Therapy After Definitive Concurrent Chemoradiotherapy",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-05-22",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04504669",
      "title": "First Time in Human Study of AZD8701 With or Without Durvalumab in Participants With Advanced Solid Tumours",
      "status": "COMPLETED",
      "last_update": "2024-11-05",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04521686",
      "title": "Study of LY3410738 Administered to Patients With Advanced Solid Tumors With IDH1 or IDH2 Mutations",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-07-22",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04540211",
      "title": "A Study of Atezolizumab Plus Tiragolumab in Combination With Paclitaxel and Cisplatin Compared With Paclitaxel and Cisplatin as First-Line Treatment in Participants With Unresectable Locally Advanced, Unresectable Recurrent, or Metastatic Esophageal Carcinoma",
      "status": "COMPLETED",
      "last_update": "2026-08-27",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04543617",
      "title": "A Study of Atezolizumab With or Without Tiragolumab in Participants With Unresectable Esophageal Squamous Cell Carcinoma Whose Cancers Have Not Progressed Following Definitive Concurrent Chemoradiotherapy",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-07-23",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04550260",
      "title": "Study of Durvalumab Versus Placebo in Combination With Definitive Chemoradiation Therapy in Patient With ESCC",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-05-13",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04564482",
      "title": "PD-L1 PET Imaging During Neoadjuvant (Chemo)Radiotherapy in Esophageal and Rectal Cancer",
      "status": "UNKNOWN",
      "last_update": "2024-03-15",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04568200",
      "title": "Study of Anti-PD-L1 in Combination With Chemo(Radio)Therapy for Resectable Esophageal Squamous Cell Carcinoma",
      "status": "COMPLETED",
      "last_update": "2024-01-22",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04601402",
      "title": "GEN-001 (Live Biotherapeutic Product) and Avelumab Combination Study for Patients With Solid Tumors Who Have Progressed on Anti-PD-(L)1 Therapy",
      "status": "COMPLETED",
      "last_update": "2023-08-08",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04625543",
      "title": "Neoadjuvant Immunotherapy to ESCC",
      "status": "WITHDRAWN",
      "last_update": "2022-04-26",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04665843",
      "title": "A Study of Atezolizumab Plus Tiragolumab and Atezolizumab Plus Placebo as First-Line Treatment in Participants With Recurrent/Metastatic PD-L1 Positive Squamous Cell Carcinoma of the Head and Neck",
      "status": "COMPLETED",
      "last_update": "2026-05-05",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04713891",
      "title": "A Study of KF-0210 in Advanced Solid Tumors Patients",
      "status": "COMPLETED",
      "last_update": "2024-09-24",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04732494",
      "title": "Anti-PD-1 Monoclonal Antibody Tislelizumab (BGB-A317) Combined With or Without Anti-TIGIT Monoclonal Antibody Ociperlimab (BGB-A1217) in Participants With Recurrent or Metastatic Esophageal Squamous Cell Carcinoma",
      "status": "COMPLETED",
      "last_update": "2025-01-31",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04795713",
      "title": "Study of MT-6402 in Subjects With Advanced Solid Cancer That Expresses PD-L1",
      "status": "TERMINATED",
      "last_update": "2024-11-04",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04831320",
      "title": "Nab-Paclitaxel in Combination With Nivolumab to Treat Recurrent or Metastatic Head and Neck Squamous-Cell Carcinoma That Progressed on a PD-1 or PD-L1 Inhibitor",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-07-06",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT04851132",
      "title": "Radiotherapy Plus Durvalumab in Elderly Esophageal Squamous Cell Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2021-06-22",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04862455",
      "title": "NBTXR3, Radiation Therapy, and Pembrolizumab for the Treatment of Recurrent or Metastatic Head and Neck Squamous Cell Cancer",
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      "last_update": "2026-01-23",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04881045",
      "title": "Study to Test the Safety and Tolerability of PF-07257876 in Participants With Selected Advanced Tumors.",
      "status": "COMPLETED",
      "last_update": "2026-06-02",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04895345",
      "title": "A Study of TQB2450 in Combination With Intensity-modulated Radiotherapy in Patients With Inoperable Locally Recurrent Nasopharyngeal Carcinoma",
      "status": "COMPLETED",
      "last_update": "2024-09-26",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04916002",
      "title": "A Trial To Find Out If Vidutolimod Together With Cemiplimab Is Safe And If It Works In Adult Participants With Advanced Cancer Or Metastatic Cancer",
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      "last_update": "2026-06-09",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04939480",
      "title": "Window of Opportunity Study of Preoperative Immunotherapy With Atezolizumab in Local SCCHN",
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      "last_update": "2024-04-25",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04949256",
      "title": "Efficacy and Safety of Pembrolizumab (MK-3475) Plus Lenvatinib (E7080/MK-7902) Plus Chemotherapy in Participants With Metastatic Esophageal Carcinoma (MK-7902-014/E7080-G000-320/LEAP-014).",
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      "last_update": "2026-08-21",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT04969861",
      "title": "BEMPEG With Pembrolizumab vs Pembrolizumab Alone in Patients With Metastatic or Recurrent HNSCC (PROPEL-36)",
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      "last_update": "2023-01-12",
      "phase": "PHASE2/PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04999800",
      "title": "Study of Pembrolizumab Combined With Anlotinib in the First Line Therapy for R/M HNSCC With CPS\u22651",
      "status": "UNKNOWN",
      "last_update": "2021-08-11",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05001347",
      "title": "A Clinical Study of TJ004309 With Atezolizumab (TECENTRIQ\u00ae) in Patients With Ovarian Cancer and Selected Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2025-12-16",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05007613",
      "title": "Second-line Cabozantinib and Atezolizumab in Patients With Recurrent or Metastatic Esophageal Squamous Cell Carcinoma",
      "status": "COMPLETED",
      "last_update": "2025-01-01",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05053737",
      "title": "Radiotherapy in Combination With Atezolizumab Prior to Surgical Resection for HPV Unrelated HNSCC",
      "status": "COMPLETED",
      "last_update": "2025-02-03",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05061537",
      "title": "Study of PF-07263689 in Participants With Selected Advanced Solid Tumors",
      "status": "TERMINATED",
      "last_update": "2024-04-12",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05063552",
      "title": "Testing the Use of Investigational Drugs Atezolizumab and/or Bevacizumab With or Without Standard Chemotherapy in the Second-Line Treatment of Advanced-Stage Head and Neck Cancers",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-07-31",
      "phase": "PHASE2/PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05069935",
      "title": "FT538 in Combination With Monoclonal Antibodies in Advanced Solid Tumors",
      "status": "TERMINATED",
      "last_update": "2023-09-21",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05077709",
      "title": "IO102-IO103 in Combination With Pembrolizumab as First-line Treatment for Patients With Metastatic NSCLC, SCCHN, or mUBC",
      "status": "COMPLETED",
      "last_update": "2026-04-08",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05091190",
      "title": "Immunotherapy Clearance and Phenotype of Circulating Tumor Cells in Lung and Head and Neck Cancers",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-09-11",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05110781",
      "title": "Atezolizumab Before Surgery for the Treatment of Regionally Metastatic Head and Neck Squamous Cell Cancer With an Unknown or Historic Primary Site",
      "status": "TERMINATED",
      "last_update": "2026-06-05",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05162872",
      "title": "Niraparib And Sintilimab In Recurrent/Metastatic Nasopharyngeal Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2021-12-17",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05222932",
      "title": "Oncolytic Adenovirus TILT-123 and Avelumab for Treatment of Solid Tumors Refractory to or Progressing After Anti-PD(L)1",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-08-07",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05234606",
      "title": "A Safety and Preliminary Efficacy Study of SBT6290 Alone and in Combination With PD-(L)1 Inhibitors in Select Advanced Solid Tumors",
      "status": "WITHDRAWN",
      "last_update": "2022-04-12",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05249426",
      "title": "A Study to Test Whether Different Combinations of BI 765063, Ezabenlimab, Chemotherapy, Cetuximab, and BI 836880 Help People With Head and Neck Cancer or Liver Cancer",
      "status": "COMPLETED",
      "last_update": "2026-07-07",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05253053",
      "title": "To Evaluate Efficacy and Safety of TT-00420 (Tinengotinib) as Monotherapy and Combination Therapy in Patients With Advanced Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2025-06-12",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05259319",
      "title": "Study Evaluating the Safety and the Efficacy of Combination of Atezolizumab, Tiragolumab and and Stereotactic Body Radiation Therapy in Patients With Oligometastatic Multiorgan (IMMUNOs-SBRT)",
      "status": "UNKNOWN",
      "last_update": "2023-10-17",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05281003",
      "title": "Pembrolizumab Plus Chemo in Neoadjuvant Treatment of Esophageal Squamous Cell Carcinoma (Eastern Cooperative Thoracic Oncology Projects 2004, ECTOP-2004)",
      "status": "UNKNOWN",
      "last_update": "2023-07-13",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05287113",
      "title": "Study of Retinfanlimab in Combination With INCAGN02385 and INCAGN02390 as First-Line Treatment in Participants With PD-L1-Positive (CPS \u2265 1) Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-03-27",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05359692",
      "title": "INCAGN01876 in Combination With Immunotherapy in Participants With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma",
      "status": "WITHDRAWN",
      "last_update": "2023-09-15",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05386056",
      "title": "Pembrolizumab and Photodynamic Therapy in Previously Treated Metastatic Esophageal Squamous Cell Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2022-11-28",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05395052",
      "title": "FT536 Monotherapy and in Combination With Monoclonal Antibodies in Advanced Solid Tumors",
      "status": "TERMINATED",
      "last_update": "2023-09-21",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05408871",
      "title": "Non-invasive Measurement of PD-L1 Levels With Positron Emission Tomography (PET) in Head and Neck Malignancies and Intracranial Metastases",
      "status": "TERMINATED",
      "last_update": "2024-02-15",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05429866",
      "title": "Immunological Variables Associated to ICI Toxicity in Cancer Patients",
      "status": "UNKNOWN",
      "last_update": "2023-03-08",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05433116",
      "title": "Pembrolizumab and Lenvatinib After Definitive Chemoradiation of Locally Advanced HNSCC",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-12-02",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05450484",
      "title": "Quantitative Fluorescence Endoscopy Using Durvalumab-680LT in Esophageal Cancer",
      "status": "COMPLETED",
      "last_update": "2026-04-13",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05459129",
      "title": "A Study Evaluating Efficacy and Safety of Multiple Treatment Combinations in Patients With Locally Advanced Squamous Cell Carcinoma of the Head and Neck (Morpheus-Head and Neck Cancer)",
      "status": "COMPLETED",
      "last_update": "2025-09-15",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05461794",
      "title": "Study To Investigate the Efficacy and Safety of Sitravatinib in Combination With Tislelizumab in Participants With Esophageal Squamous Cell Carcinoma",
      "status": "TERMINATED",
      "last_update": "2025-06-13",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05523323",
      "title": "A Study of Pembrolizumab (MK-3475) With or Without Lenvatinib (E7080/MK-7902) as First Line (1L) Intervention in a Programmed Cell Death-ligand 1 (PD-L1) Selected Population With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma (R/M HNSCC) (MK-7902-010/LEAP-010)-China Extension",
      "status": "COMPLETED",
      "last_update": "2026-03-13",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05576077",
      "title": "A Study of TBio-4101 (TIL) and Pembrolizumab in Patients With Advanced Solid Tumors",
      "status": "TERMINATED",
      "last_update": "2025-03-10",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05577182",
      "title": "Study of INCA32459 a LAG-3 and PD-1 Bispecific Antibody in Participants With Select Advanced Malignancies",
      "status": "COMPLETED",
      "last_update": "2025-11-03",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05581004",
      "title": "A Study to Evaluate the Safety, Pharmacokinetics, and Activity of Enzelkitug as a Single Agent and in Combination With Checkpoint Inhibitor in Participants With Locally Advanced or Metastatic Solid Tumors",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-08-06",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05655663",
      "title": "Evaluation of Vascular Toxicity of Immune Checkpoint Inhibitors in Patients Head and Neck or Lung Cancer",
      "status": "UNKNOWN",
      "last_update": "2022-12-19",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05667298",
      "title": "Organ-Preserving Endoscopic Resection & Adjuvant RADIO-immuno-chemotherapy for Esophageal Cancer",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-05-11",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05681039",
      "title": "Phase 2 Trial of Neoadjuvant and Adjuvant Tiragolumab Plus Atezolizumab in Patients With Newly Diagnosed PD-L1 CPS Positive Resectable Stage 3-4 Oral Cavity Squamous Cell Carcinoma (OCSCC).",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-06-02",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05787587",
      "title": "A Study of PARG Inhibitor IDE161 in Participants With Advanced Solid Tumors",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-07-13",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06016413",
      "title": "Adelbelimab Combination Chemotherapy in Neoadjuvant Therapy for Squamous Cell Carcinoma of the Head and Neck",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2023-08-29",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06082167",
      "title": "Study of Zanzalintinib (XL092) + Pembrolizumab vs Pembrolizumab in Subjects With PD-L1 Positive Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-08-17",
      "phase": "PHASE2/PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06090318",
      "title": "Milademetan in Combination With Atezolizumab in Patients With Advanced Solid Tumors With CDKN2A Loss",
      "status": "WITHDRAWN",
      "last_update": "2023-10-19",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06118333",
      "title": "A Study Comparing BL-B01D1 With Physician's Choice of Chemotherapy in Patients With Recurrent or Metastatic Nasopharyngeal Carcinoma(PANKU-NPC01)",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-04-17",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06146985",
      "title": "Famitinib in Combination With Adebrelimab for the Treatment of Advanced Thyroid Cancer",
      "status": "UNKNOWN",
      "last_update": "2023-11-28",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06285097",
      "title": "A Study of PF-07820435 as a Single Agent and in Combination in Participants With Advanced Solid Tumors",
      "status": "TERMINATED",
      "last_update": "2025-09-17",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06295731",
      "title": "INBRX-106 in Combination With Pembrolizumab in First-line PD-L1 CPS\u226520 HNSCC",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-05-08",
      "phase": "PHASE2/PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06304974",
      "title": "A Study Comparing BL-B01D1 With Chemotherapy of Physician's Choice in Patients With Recurrent or Metastatic Esophageal Squamous Cell Carcinoma(PANKU-Esophagus01)",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-07-23",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06446570",
      "title": "Phase II Study of Durvalumab(MEDI4736) + Tremelimumab in Pulmonary Sarcomatoid Carcinoma",
      "status": "COMPLETED",
      "last_update": "2024-06-06",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06513884",
      "title": "A Study of HB-202/HB-201 With Pembrolizumab in Patients With HPV16+ Recurrent/Metastatic Oropharyngeal Cancer",
      "status": "WITHDRAWN",
      "last_update": "2025-06-22",
      "phase": "PHASE2/PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06546553",
      "title": "A Study to Learn About How Different Amounts of the Study Medicine PF-07826390 Act in the Body of People With Cancer When Taken Alone or With Other Anti-cancer Medicines.",
      "status": "TERMINATED",
      "last_update": "2026-02-23",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06557889",
      "title": "Reduction in the Number of Chemotherapy Cycles in Combination With Pembrolizumab in First-line Treatment of PD-L1-positive Recurrent or Metastatic Head and Neck Squamous Cell Carcinomas",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-09-11",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06629597",
      "title": "A Phase III Study of YL201 in Recurrent or Metastatic Nasopharyngeal Carcinoma(TAISHAN-301)",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-09-02",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06690216",
      "title": "Evaluation of [18F]AlF-NOTA-PCP2 PET/CT for PD-L1 Detection in Malignant Tumors",
      "status": "ENROLLING_BY_INVITATION",
      "last_update": "2025-03-30",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06727565",
      "title": "Study of Novel Treatment Combination Therapies in Participants With Head and Neck Squamous Cell Carcinoma Regardless of PD-L1 Expression Status; Substudy-01",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-09-03",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06919666",
      "title": "NT219 Combined With Standard of Care Biologic Therapy in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-07-02",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06974734",
      "title": "A Clinical Trial of PF-08046037 Alone or With Sasanlimab in Patients With Advanced or Metastatic Malignancies",
      "status": "TERMINATED",
      "last_update": "2026-04-23",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07010393",
      "title": "Genotype-Driven Neoadjuvant Therapy for Locally Advanced Thyroid Cancer: A Real-World Cohort Study",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2025-06-08",
      "phase": "PHASE4",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07137858",
      "title": "Adebrelimab Combined With Carboplatin and Albumin-bound Taxanol in the Treatment of Resectable Locally Advanced Oral Squamous Cell Carcinoma Cardiac, Randomized, Phase II Exploratory Study",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2025-08-22",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07196384",
      "title": "Optical PD-1 and PD-L1 Imaging in Locally Advanced Esophageal Cancer Using Durvalumab-680LT and Nivolumab-800CW",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2025-11-21",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07354984",
      "title": "A Single-Arm Phase II Clinical Study of Docetaxel Combined With Nimotuzumab and Pucotenlimab as Second-Line and Beyond Therapy for Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2026-01-21",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07565857",
      "title": "Signatera-Guided De-escalation of Adjuvant Therapy in Resectable Stage II-IVa Gastric/Gastric-Esophageal Cancer",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2026-05-04",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07589049",
      "title": "Becotatug Vedotin Combined With Pucotenlimab as Neoadjuvant Therapy for Resectable Recurrent Head and Neck Squamous Cell Carcinoma After Progression on Immunotherapy: A Prospective Phase II Study",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2026-05-15",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07625930",
      "title": "RESTAGE (REpurposing STAtins to Improve Outcomes in GastroEsophageal Cancer) Trial",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2026-07-10",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07628062",
      "title": "Phase 2 Study of NAI, HPV Vaccine, and Nab-Paclitaxel in HPV-Positive Oropharyngeal Cancer Followed by De-Intensified Radiation Compared With Standard Chemoradiation",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2026-06-04",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07662720",
      "title": "A Phase II Trial for MOR Antagonism With Axelopran to Enhance Immunotherapy in Head and Neck Cancer",
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     {
      "nct": "NCT07766889",
      "title": "Neoadjuvant Presurgical Becotatug Vedotin (MRG003) Plus Pucotenlimab (HX008) in Oral Cavity Squamous Cell Carcinoma",
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     {
      "nct": "NCT07769866",
      "title": "Retlirafusp Alfa Combined With Chemoradiotherapy in Unresectable ESCC",
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      "last_update": "2026-08-18",
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     {
      "nct": "NCT07770100",
      "title": "Concurrent Immunotherapy and Systemic Therapy With Stereotactic Body Radiation Therapy (SBRT) for Stage IV Cancers (COINSSS IV)",
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       "title": "Pembrolizumab + N-803 Alone or in Combination With PD-L1 t-haNK Cells for Resectable Head and Neck Squamous Cell Carcinoma",
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      "nct": "NCT05307939",
      "title": "A Study on Using Cell-Free Tumor DNA (ctDNA) Testing to Decide When to StartRoutine Treatment in People With Human Papilloma Virus (HPV)- Associated Oropharynx Cancer (OPC)",
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      "nct": "NCT05686226",
      "title": "E7 TCR-T Cell Immunotherapy for Human Papillomavirus (HPV) Associated Cancers",
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     {
      "nct": "NCT05799144",
      "title": "pBI-11 & TA-HPV (With Pembrolizumab as Treatment for Patients w/Advanced, PD-L1 CPS\u22651, hrHPV+ Oropharyngeal Cancer",
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     {
      "nct": "NCT06007092",
      "title": "Therapeutic Vaccine in Patients With Human Papillomavirus HPV-positive Oropharyngeal Cancer",
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     {
      "nct": "NCT06319963",
      "title": "A Study to Evaluate Lenti-HPV-07 Immunotherapy Against HPV+ Cervical or Oropharyngeal Cancer",
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      "nct": "NCT01493154",
      "title": "Safety Study of HPV DNA Vaccine to Treat Head and Neck Cancer Patients",
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     {
      "nct": "NCT02002182",
      "title": "ADXS 11-001 Vaccination Prior to Robotic Surgery, HPV-Positive Oropharyngeal Cancer",
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     {
      "nct": "NCT02865135",
      "title": "Trial To Test Safety And Efficacy Of Vaccination For Incurable HPV 16-Related Oropharyngeal, Cervical And Anal Cancer",
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      "nct": "NCT03418480",
      "title": "HARE-40: HPV Anti-CD40 RNA vaccinE",
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      "title": "Combination of UCPVax Vaccine and Atezolizumab for the Treatment of Human Papillomavirus Positive Cancers (VolATIL)",
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      "title": "Study of SQZ-PBMC-HPV in Patients With HPV16+ Recurrent, Locally Advanced or Metastatic Solid Tumors",
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      "nct": "NCT04260126",
      "title": "Study of PDS0101 and Pembrolizumab Combination I/O in Subjects With HPV16 + Recurrent and/or Metastatic HNSCC",
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      "title": "A Clinical Trial Investigating the Safety, Tolerability, and Therapeutic Effects of BNT113 in Combination With Pembrolizumab Versus Pembrolizumab Alone for Patients With a Form of Head and Neck Cancer Positive for Human Papilloma Virus 16 and Expressing the Protein PD-L1",
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      "title": "RPTR-168 in Patients With Human Papillomavirus Strain 16 (HPV-16) E6/E7 Positive Tumors and Melanoma",
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      "title": "Study of SQZ-AAC-HPV in Patients With HPV16+ Recurrent, Locally Advanced or Metastatic Solid Tumors",
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      "title": "Education, Immigration and HPV Vaccination: an Informational Randomized Trial",
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      "title": "TheraT\u00ae Vectors (Vaccines) Combined With Chemotherapy to Treat HPV16 Head and Neck Cancers",
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      "title": "A Vaccine (PDS0101) Alone or in Combination With Pembrolizumab for the Treatment of Locally Advanced Human Papillomavirus-Associated Oropharynx Cancer",
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      "title": "Study of SQZ-eAPC-HPV in Patients With HPV16+ Recurrent, Locally Advanced or Metastatic Solid Tumors",
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      "title": "Autologous T Cells Targeting HPV16 HPV18 & Survivin in Patients With R/R HPV-related Oropharyngeal Cancers",
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      "title": "Phase II Trial of Immunotherapeutic HPV Vaccine PRGN-2009 With Pembrolizumab Before Standard Treatment in Subjects With Newly Diagnosed HPV-Associated Oropharyngeal Cancer",
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      "title": "Phase II Trial of Neoadjuvant Chemotherapy (NAC) Alone or in Combination With Immunotherapy Vaccine PRGN-2009 in Subjects With Newly Diagnosed HPV-Associated Oropharyngeal (Head and Neck) Cancer",
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      "title": "CRTE7A2-01 TCR-T Cells for HPV-16 Positive Advanced Cancers",
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      "title": "Phase 3 Study of PDS0101 and Pembrolizumab in HPV16+ Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma",
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      "title": "Phase 2 Study of NAI, HPV Vaccine, and Nab-Paclitaxel in HPV-Positive Oropharyngeal Cancer Followed by De-Intensified Radiation Compared With Standard Chemoradiation",
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      "title": "177Lu-BetaBart in Patients With Relapsed/Refractory, Locally Advanced Inoperable, or Metastatic Solid Tumors",
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      "title": "A Comprehensive Multiomic Biomarker Evaluation Across Two Single-arm Cohorts to Elucidate Mechanisms of Response and Resistance in Recurrent/Metastatic (R/M) Head and Neck Squamous Cell Carcinoma (HNSCC)",
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     {
      "nct": "NCT07503808",
      "title": "A Study of IDE034 in Adult Participants With Locally Advanced/Metastatic Solid Tumors Types",
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      "last_update": "2026-06-18",
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      "nct": "NCT02628535",
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      "nct": "NCT03729596",
      "title": "MGC018 With or Without MGA012 in Advanced Solid Tumors",
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      "nct": "NCT04129320",
      "title": "Enoblituzumab Plus MGA012 or MGD013 in Squamous Cell Carcinoma of the Head and Neck",
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      "title": "Enoblituzumab Plus Retifanlimab or Tebotelimab in Head and Neck Cancer",
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      "title": "Recombinant EphB4-HSA Fusion Protein With Standard Chemotherapy Regimens in Treating Patients With Advanced or Metastatic Solid Tumors",
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      "title": "sEphB4-HSA With RT+Chemo or Cetux in Patients With Intermediate to High Risk LAHNSCC",
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      "title": "A Study of DB-1310 in Advanced/Metastatic Solid Tumors",
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     {
      "nct": "NCT05910827",
      "title": "A Phase Ib/II Study of an Anti-HER3 Antibody, HMBD-001, With Cetuximab +/- Docetaxel in Advanced Squamous Cell Cancers",
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     {
      "nct": "NCT06172478",
      "title": "A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors",
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     {
      "nct": "NCT06194656",
      "title": "Clinical Trial of SIBP-03 in Patients With Head and Neck Squamous Cell Carcinoma",
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      "last_update": "2026-01-16",
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     {
      "nct": "NCT06445972",
      "title": "Substudy 06D: Combination Therapies in Second Line (2L) Gastroesophageal Adenocarcinoma (MK-3475-06D/Keymaker-U06)",
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      "last_update": "2026-09-03",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06469944",
      "title": "Substudy 06C: A Study of Investigational Agents With Pembrolizumab (MK-3475) and Chemotherapy in Participants With First-Line Locally Advanced Unresectable/Metastatic Gastroesophageal Adenocarcinoma (MK-3475-06C/KEYMAKER-U06)",
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      "last_update": "2026-09-02",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT07038343",
      "title": "AVENTINE-1: Study of AVZO-1418 as a Single Agent and in Combination Therapy in Patients With Locally Advanced or Metastatic Solid Tumors (AVZO-1418-1001)",
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      "last_update": "2026-09-04",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01451632",
      "title": "A Safety Study of MM-121 With Cetuximab and Irinotecan in Patients With Advanced Cancers",
      "status": "COMPLETED",
      "last_update": "2016-09-08",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02350712",
      "title": "Patritumab With Cetuximab and a Platinum Containing Therapy for Patients With Head and Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2018-09-11",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
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      "title": "Neoadjuvant Adebrelimab With Dalpiciclib for Resectable Esophageal Squamous Cell Carcinomas",
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      "title": "Study of SHR-8068 Combined With Adebrelimab and Platinum-containing Chemotherapy in the Treatment of Advanced Gastric and Esophageal Cancer",
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      "title": "Adebrelimab Combined With Chemoradiotherapy for Locally Advanced Unresectable Esophageal Squamous Cell Carcinoma (ESCC)",
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      "title": "Adebrelimab in Combination With Apatinib and Chemotherapy/Chemoradiotherapy in Immuno-experienced Second-line ESCC.",
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      "nct": "NCT07770672",
      "title": "An Exploratory Clinical Study of Accurate Efficacy Assessment of Neoadjuvant Immunotherapy in Locally Advanced Esophageal Squamous Cell Carcinoma Based on 68Ga-FAPI ([68Ga] Fibroblast Activation Protein Inhibitor)/\u00b9\u2078F-FDG (2-Deoxy-2-[\u00b9\u2078F]Fluoro-D-glucose) Dual Imaging",
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      "title": "Adebrelimab Combined With Dalpiciclib Isethionate Plus Chemotherapy for Neoadjuvant Treatment of Locally Advanced Head and Neck Squamous Cell Carcinoma",
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     {
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      "title": "Study of Adebrelimab Combined With Thymalfasin and Chemotherapy for Neoadjuvant Treatment of Esophageal Cancer",
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      "title": "A Trial of the Combination of Afatinib and Palbociclib in Previously Treated Advanced Esophageal Squamous Cell Carcinoma",
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      "title": "BIBW 2992 (Afatinib) in Head & Neck Cancer",
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      "title": "Research of Biomarkers of Activity and Efficacy of BIBW2992 in Untreated Non-metastatic HNSCC Patients",
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     {
      "nct": "NCT01427478",
      "title": "Evaluation of Afatinib in Maintenance Therapy in Squamous Cell Carcinoma of the Head and Neck",
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      "title": "Afatinib and Paclitaxel in Patients With Advanced HER2-Positive Trastuzumab-Refractory Advanced Esophagogastric Cancer",
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      "title": "Neoadjuvant Afatinib Window Study in Squamous Cell Carcinoma of the Head and Neck",
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      "title": "Induction Chemotherapy With Afatinib, Ribavirin, and Weekly Carboplatin/Paclitaxel for Stage IVA/IVB HPV Associated Oropharynx Squamous Cell Cancer (OPSCC)",
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      "title": "A Phase I/II Study Afatinib/Carboplatin/Paclitaxel Induction Chemotherapy In HPV-Negative HNSCC.",
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      "title": "Safety Study of Afatinib and Postoperative Radiation Therapy to Treat Head and Neck Cancer",
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     {
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      "title": "Afatinib After Chemoradiation and Surgery in Treating Patients With Stage III-IV Squamous Cell Carcinoma of the Head and Neck at High-Risk of Recurrence",
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      "title": "LUX-Head&Neck 3: Afatinib (BIBW2992) Versus Methotrexate for the Treatment of Recurrent and/or Metastatic Head and Neck Squamous Cell Cancer After Platinum Based Chemotherapy",
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     {
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      "title": "LUX-Head & Neck 4: Afatinib (BIBW 2992) Versus Placebo for the Treatment of Head and Neck Squamous Cell Cancer After Treatment With Chemo-radiotherapy",
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     {
      "nct": "NCT02145637",
      "title": "Phase I Study of the Combination of Afatinib and Ruxolitinib in Patients With Treatment-refractory Non-Small Cell Lung Cancer (NSCLC)",
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      "last_update": "2019-03-29",
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     {
      "nct": "NCT02216617",
      "title": "Evaluation of the Tolerance of Afatinib in Combination With Docetaxel and Cisplatin in LAHNSCC Induction Chemotherapy",
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      "phase": "PHASE1",
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     {
      "nct": "NCT02274012",
      "title": "Trial of Afatinib in Combination With Weekly Paclitaxel in the Second Line Treatment",
      "status": "WITHDRAWN",
      "last_update": "2017-03-14",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT02353936",
      "title": "A Phase II Trial of Afatinib in Patients With Metastatic or Recurrent Squamous Cell Carcinoma of Esophagus",
      "status": "UNKNOWN",
      "last_update": "2019-02-11",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT02465060",
      "title": "Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)",
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      "last_update": "2026-08-28",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT02979977",
      "title": "Dual Inhibition of EGFR With Afatinib and Cetuximab in the Treatment of Advanced Squamous Cell Cancers of the Head and Neck",
      "status": "COMPLETED",
      "last_update": "2026-02-04",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03088059",
      "title": "Biomarker-based Study in R/M SCCHN",
      "status": "UNKNOWN",
      "last_update": "2023-11-03",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03652233",
      "title": "Afatinib and Nivolumab as Treatment for Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck",
      "status": "WITHDRAWN",
      "last_update": "2019-06-20",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03695510",
      "title": "Afatinib and Pembrolizumab for Head and Neck Squamous Cell Carcinoma (ALPHA Study)",
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      "last_update": "2022-04-21",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03940976",
      "title": "Afatinib in Previously Treated ESCC With EGFR Overexpression or EGFR Amplification (ESCC-A01)",
      "status": "UNKNOWN",
      "last_update": "2019-06-11",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04839471",
      "title": "BI-754091 and Afatinib for Refractory Esophageal Squamous Cell Carcinoma (BEAR Study)",
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      "last_update": "2024-07-08",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04880811",
      "title": "Afatinib Plus Toripalimab in Previously Treated ESCC With EGFR Overexpression or EGFR Amplification",
      "status": "UNKNOWN",
      "last_update": "2021-07-13",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05516589",
      "title": "Neoadjuvant Chemotherapy, Tislelizumab With Afatinib for HNSCC",
      "status": "COMPLETED",
      "last_update": "2025-05-22",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05517330",
      "title": "Neoadjuvant Tislelizumab With Afatinib for Resectable Head and Neck Squamous Cell Carcinoma",
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      "last_update": "2025-07-31",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05865132",
      "title": "Palbociclib Combined With Afatinib for Advanced Squamous Carcinoma of Esophagus or Gastroesophageal Junction",
      "status": "UNKNOWN",
      "last_update": "2023-05-18",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05927844",
      "title": "XH-30002 Capsule Combined With Afatinib Tablets for the Treatment of Squamous Cell Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2023-07-03",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06494189",
      "title": "Low-dose Radiotherapy Plus Tislelizumab in Combination With Afatinib for Neoadjuvant Treatment of Surgically Resectable Head and Neck Squamous Carcinoma",
      "status": "COMPLETED",
      "last_update": "2025-12-29",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06804850",
      "title": "Neoadjuvant Radiotherapy Plus Targeted Therapy and Immunotherapy vs. Targeted Therapy Plus Immunotherapy in Resectable HNSCC",
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      "last_update": "2025-11-19",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06897735",
      "title": "Exploratory Study of Inhaled Afatinib Dimaleate PK Profile",
      "status": "TERMINATED",
      "last_update": "2026-06-03",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07010120",
      "title": "A Clinical Trial of Neoadjuvant Targeted Therapy, Immunotherapy, and Lysogenic HSV-Based Virotherapy in Resectable Head and Neck Squamous Cell Carcinoma",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-07-01",
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      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07040956",
      "title": "A Clinical Trial Comparing Low-Dose RT + Targeted Therapy+ Immunotherapy vs Targeted Therapy+ Immunotherapy Alone as Neoadjuvant Therapy in Operable HNSCC Patients.",
      "status": "COMPLETED",
      "last_update": "2026-06-30",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07653451",
      "title": "Precision Medicine for Immunotherapy-Resistant Advanced Esophageal Cancer",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2026-06-17",
      "phase": "PHASE2/PHASE3",
      "study_type": "INTERVENTIONAL"
     }
    ]
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     {
      "nct": "NCT06648096",
      "title": "Afatinib in Patients With Fanconi Anemia (FA) and Advanced Head and Neck Squamous Cell Carcinoma (HNSCC)",
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      "last_update": "2026-05-27",
      "phase": "PHASE1/PHASE2",
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     },
     {
      "nct": "NCT06741982",
      "title": "A Clinical Study on Neoadjuvant Treatment of Resectable Head and Neck Squamous Carcinoma With Immune-targeted Therapy and Lysogenic HSV Virus",
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      "last_update": "2024-12-19",
      "phase": "PHASE1",
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     {
      "nct": "NCT06753747",
      "title": "A Trial of the Combination of Afatinib and Palbociclib in Previously Treated Advanced Esophageal Squamous Cell Carcinoma",
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      "last_update": "2025-12-03",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00514943",
      "title": "BIBW 2992 (Afatinib) in Head & Neck Cancer",
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      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01345669",
      "title": "LUX-Head&Neck 2: A Phase III Trial of Afatinib (BIBW 2992) Versus Placebo for the Treatment of Head and Neck Squamous Cell Cancer After Treatment With Chemo-radiotherapy",
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      "last_update": "2017-12-07",
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     {
      "nct": "NCT01345682",
      "title": "LUX-Head&Neck 1: A Phase III Trial of Afatinib (BIBW2992) Versus Methotrexate for the Treatment of Recurrent and/or Metastatic (R/M) Head and Neck Squamous Cell Cancer After Platinum Based Chemotherapy",
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      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01415674",
      "title": "Research of Biomarkers of Activity and Efficacy of BIBW2992 in Untreated Non-metastatic HNSCC Patients",
      "status": "COMPLETED",
      "last_update": "2022-02-02",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01427478",
      "title": "Evaluation of Afatinib in Maintenance Therapy in Squamous Cell Carcinoma of the Head and Neck",
      "status": "COMPLETED",
      "last_update": "2021-06-01",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01522768",
      "title": "Afatinib and Paclitaxel in Patients With Advanced HER2-Positive Trastuzumab-Refractory Advanced Esophagogastric Cancer",
      "status": "COMPLETED",
      "last_update": "2023-11-01",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01538381",
      "title": "Neoadjuvant Afatinib Window Study in Squamous Cell Carcinoma of the Head and Neck",
      "status": "COMPLETED",
      "last_update": "2018-07-09",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01721525",
      "title": "Induction Chemotherapy With Afatinib, Ribavirin, and Weekly Carboplatin/Paclitaxel for Stage IVA/IVB HPV Associated Oropharynx Squamous Cell Cancer (OPSCC)",
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      "last_update": "2017-10-25",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01732640",
      "title": "A Phase I/II Study Afatinib/Carboplatin/Paclitaxel Induction Chemotherapy In HPV-Negative HNSCC.",
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      "last_update": "2018-07-26",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01783587",
      "title": "Safety Study of Afatinib and Postoperative Radiation Therapy to Treat Head and Neck Cancer",
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      "last_update": "2026-03-25",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01824823",
      "title": "Afatinib After Chemoradiation and Surgery in Treating Patients With Stage III-IV Squamous Cell Carcinoma of the Head and Neck at High-Risk of Recurrence",
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      "last_update": "2023-06-28",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01856478",
      "title": "LUX-Head&Neck 3: Afatinib (BIBW2992) Versus Methotrexate for the Treatment of Recurrent and/or Metastatic Head and Neck Squamous Cell Cancer After Platinum Based Chemotherapy",
      "status": "COMPLETED",
      "last_update": "2026-01-12",
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      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02131155",
      "title": "LUX-Head & Neck 4: Afatinib (BIBW 2992) Versus Placebo for the Treatment of Head and Neck Squamous Cell Cancer After Treatment With Chemo-radiotherapy",
      "status": "TERMINATED",
      "last_update": "2019-03-01",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02145637",
      "title": "Phase I Study of the Combination of Afatinib and Ruxolitinib in Patients With Treatment-refractory Non-Small Cell Lung Cancer (NSCLC)",
      "status": "COMPLETED",
      "last_update": "2019-03-29",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02216617",
      "title": "Evaluation of the Tolerance of Afatinib in Combination With Docetaxel and Cisplatin in LAHNSCC Induction Chemotherapy",
      "status": "COMPLETED",
      "last_update": "2017-10-27",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02274012",
      "title": "Trial of Afatinib in Combination With Weekly Paclitaxel in the Second Line Treatment",
      "status": "WITHDRAWN",
      "last_update": "2017-03-14",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02353936",
      "title": "A Phase II Trial of Afatinib in Patients With Metastatic or Recurrent Squamous Cell Carcinoma of Esophagus",
      "status": "UNKNOWN",
      "last_update": "2019-02-11",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02465060",
      "title": "Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-08-28",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02979977",
      "title": "Dual Inhibition of EGFR With Afatinib and Cetuximab in the Treatment of Advanced Squamous Cell Cancers of the Head and Neck",
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      "last_update": "2026-02-04",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03088059",
      "title": "Biomarker-based Study in R/M SCCHN",
      "status": "UNKNOWN",
      "last_update": "2023-11-03",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03652233",
      "title": "Afatinib and Nivolumab as Treatment for Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck",
      "status": "WITHDRAWN",
      "last_update": "2019-06-20",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT03695510",
      "title": "Afatinib and Pembrolizumab for Head and Neck Squamous Cell Carcinoma (ALPHA Study)",
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      "last_update": "2022-04-21",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT03940976",
      "title": "Afatinib in Previously Treated ESCC With EGFR Overexpression or EGFR Amplification (ESCC-A01)",
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      "last_update": "2019-06-11",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT04839471",
      "title": "BI-754091 and Afatinib for Refractory Esophageal Squamous Cell Carcinoma (BEAR Study)",
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      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT04880811",
      "title": "Afatinib Plus Toripalimab in Previously Treated ESCC With EGFR Overexpression or EGFR Amplification",
      "status": "UNKNOWN",
      "last_update": "2021-07-13",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05516589",
      "title": "Neoadjuvant Chemotherapy, Tislelizumab With Afatinib for HNSCC",
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      "last_update": "2025-05-22",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05517330",
      "title": "Neoadjuvant Tislelizumab With Afatinib for Resectable Head and Neck Squamous Cell Carcinoma",
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      "last_update": "2025-07-31",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT05865132",
      "title": "Palbociclib Combined With Afatinib for Advanced Squamous Carcinoma of Esophagus or Gastroesophageal Junction",
      "status": "UNKNOWN",
      "last_update": "2023-05-18",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05927844",
      "title": "XH-30002 Capsule Combined With Afatinib Tablets for the Treatment of Squamous Cell Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2023-07-03",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06494189",
      "title": "Low-dose Radiotherapy Plus Tislelizumab in Combination With Afatinib for Neoadjuvant Treatment of Surgically Resectable Head and Neck Squamous Carcinoma",
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      "last_update": "2025-12-29",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06804850",
      "title": "Neoadjuvant Radiotherapy Plus Targeted Therapy and Immunotherapy vs. Targeted Therapy Plus Immunotherapy in Resectable HNSCC",
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      "phase": "PHASE2",
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     {
      "nct": "NCT06897735",
      "title": "Exploratory Study of Inhaled Afatinib Dimaleate PK Profile",
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      "last_update": "2026-06-03",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07010120",
      "title": "A Clinical Trial of Neoadjuvant Targeted Therapy, Immunotherapy, and Lysogenic HSV-Based Virotherapy in Resectable Head and Neck Squamous Cell Carcinoma",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-07-01",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07040956",
      "title": "A Clinical Trial Comparing Low-Dose RT + Targeted Therapy+ Immunotherapy vs Targeted Therapy+ Immunotherapy Alone as Neoadjuvant Therapy in Operable HNSCC Patients.",
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      "last_update": "2026-06-30",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07653451",
      "title": "Precision Medicine for Immunotherapy-Resistant Advanced Esophageal Cancer",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2026-06-17",
      "phase": "PHASE2/PHASE3",
      "study_type": "INTERVENTIONAL"
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      "nct": "NCT05768139",
      "title": "First-in-Human Study of Tersolisib (STX-478) as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors",
      "status": "RECRUITING",
      "last_update": "2026-07-07",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06145308",
      "title": "Precision Treatment of Recurrent/Metastatic Salivary Gland Carcinoma Guided by Molecular Typing",
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      "last_update": "2026-04-02",
      "phase": "PHASE2",
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     {
      "nct": "NCT06993844",
      "title": "Phase 1/2 Study of ETX-636 in Participants With Advanced Solid Tumors",
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      "last_update": "2026-06-23",
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      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT01602315",
      "title": "A Phase Ib/II Study of BYL719 and Cetuximab in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma",
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      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT01822613",
      "title": "Study of Safety & Efficacy of the Combination of LJM716 & BYL719 in Patients With Previously Treated Esophageal Squamous Cell Carcinoma (ESCC)",
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      "last_update": "2020-12-19",
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      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02051751",
      "title": "A Study to Evaluate the Potential Benefit of the Addition of BYL719 to Paclitaxel in the Treatment of Breast Cancer and Head-and-neck Cancer",
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      "last_update": "2020-12-08",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02282371",
      "title": "Cetuximab + BYL719 + IMRT (Intensity-Modulated Radiation Therapy) in Stage III/IVB Head and Neck Squamous Cell Cancer (HNSCC)",
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      "last_update": "2021-10-26",
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      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02298595",
      "title": "Cetuximab, Cisplatin and BYL719 for HPV-Associated Oropharyngeal Squamous Cell Carcinoma",
      "status": "WITHDRAWN",
      "last_update": "2017-11-13",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02537223",
      "title": "Phase I Study of BYL719 in Combination With Cisplatin and Radiotherapy in Patients With Squamous Cell Head and Neck Cancer",
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      "last_update": "2021-04-19",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT03138070",
      "title": "A Window of Opportunity Study to Assess the Modulation of Biomarkers in Head and Neck Squamous Cell Cancer (HNSCC) By Preoperative Treatment With BYL719",
      "status": "COMPLETED",
      "last_update": "2026-01-28",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03292250",
      "title": "Korean Cancer Study Group: Translational bIomarker Driven UMbrella Project for Head and Neck (TRIUMPH), Esophageal Squamous Cell Carcinoma- Part 1 (HNSCC)]",
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      "last_update": "2022-03-29",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03601507",
      "title": "Alpelisib in Treating Participants With Transorally Resectable HPV-Associated Stage I-IVA Oropharyngeal Cancer",
      "status": "TERMINATED",
      "last_update": "2024-04-17",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04997902",
      "title": "Combination Trial of Tipifarnib and Alpelisib in Adult Recurrent/ Metastatic Head and Neck Squamous Cell Carcinoma (R/M HNSCC)",
      "status": "COMPLETED",
      "last_update": "2026-09-08",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     }
    ]
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     {
      "nct": "NCT06385080",
      "title": "A Study of Amivantamab Alone or in Addition to Other Treatment Agents in Participants With Head and Neck Cancer",
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      "last_update": "2026-08-28",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07276399",
      "title": "A Study of Amivantamab in Addition to Standard of Care Agents (SOC) Compared With SOC Alone in Participants With Recurrent/Metastatic Head and Neck Cancer",
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      "last_update": "2026-08-28",
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     {
      "nct": "NCT04945733",
      "title": "A Study of Amivantamab in Participants With Previously Treated Advanced or Metastatic Gastric or Esophageal Cancer",
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      "last_update": "2024-09-19",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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      "nct": "NCT05074940",
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      "title": "Testing Docetaxel-Cetuximab or the Addition of an Immunotherapy Drug, Atezolizumab, to the Usual Chemotherapy and Radiation Therapy in High-Risk Head and Neck Cancer",
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      "title": "A Study of Autogene Cevumeran (RO7198457) as a Single Agent and in Combination With Atezolizumab in Participants With Locally Advanced or Metastatic Tumors",
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      "title": "Basket Study to Evaluate the Therapeutic Activity of Simlukafusp Alfa as a Combination Therapy in Participants With Advanced and/or Metastatic Solid Tumors",
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      "nct": "NCT03399071",
      "title": "Study Title: Peri-operative Immuno-Chemotherapy in Operable Oesophageal and Gastric Cancer",
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      "nct": "NCT03511391",
      "title": "CHEckpoint Inhibition in Combination With an Immunoboost of External Beam Radiotherapy in Solid Tumors",
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      "nct": "NCT03544723",
      "title": "Safety and Efficacy of p53 Gene Therapy Combined With Immune Checkpoint Inhibitors in Solid Tumors.",
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      "nct": "NCT03693014",
      "title": "A Study of Several Radiation Doses for Patients With Progression on Immunotherapy/Checkpoint Inhibitors",
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      "nct": "NCT03708224",
      "title": "Preoperative Immunotherapy in Patients With Squamous Cell Carcinoma of the Head and Neck",
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     {
      "nct": "NCT03818061",
      "title": "Atezolizumab and Bevacizumab in Patients With Recurrent or Metastatic Squamous-cell Carcinoma of the Head and Neck",
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      "nct": "NCT03818997",
      "title": "Combination of Targeted and Immunotherapy for Advanced Biliary Tract and Esophagogastric Gastric Cancer",
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      "title": "A Phase 1/2, Open-label, Multi-center Study of the Safety and Efficacy of Alomfilimab (KY1044) as Single Agent and in Combination With Anti-PD-L1 (Atezolizumab) in Adult Patients With Selected Advanced Malignancies",
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      "title": "FT500 as Monotherapy and in Combination With Immune Checkpoint Inhibitors in Subjects With Advanced Solid Tumors",
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      "title": "Study of SQZ-PBMC-HPV in Patients With HPV16+ Recurrent, Locally Advanced or Metastatic Solid Tumors",
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      "title": "Safety and Efficacy of SB 11285 Alone and in Combination With Atezolizumab in Patients With Advanced Solid Tumors",
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      "title": "Evaluating Length of Treatment With PD-1/PD-L1 Inhibitor in Advanced Solid Tumors",
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      "nct": "NCT04166721",
      "title": "WaKING: Wnt and checKpoint INhibition in Gastric Cancer",
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      "nct": "NCT04220775",
      "title": "Bintrafusp Alfa and Stereotactic Body Radiation Therapy for the Treatment of Recurrent or Second Primary Head and Neck Squamous Cell Cancer",
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      "title": "HPV Vaccine PRGN-2009 Alone or in Combination With Anti-PDL1/TGF-Beta Trap (M7824) in Subjects With HPV Associated Cancers",
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      "title": "A Study of NM21-1480 in Adult Patients With Advanced Solid Tumors",
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      "nct": "NCT04477759",
      "title": "Dose-Escalated Hypofractionated Adaptive Radiotherapy for Head and Neck Cancer",
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      "nct": "NCT04504669",
      "title": "First Time in Human Study of AZD8701 With or Without Durvalumab in Participants With Advanced Solid Tumours",
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     {
      "nct": "NCT04540211",
      "title": "A Study of Atezolizumab Plus Tiragolumab in Combination With Paclitaxel and Cisplatin Compared With Paclitaxel and Cisplatin as First-Line Treatment in Participants With Unresectable Locally Advanced, Unresectable Recurrent, or Metastatic Esophageal Carcinoma",
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     {
      "nct": "NCT04543617",
      "title": "A Study of Atezolizumab With or Without Tiragolumab in Participants With Unresectable Esophageal Squamous Cell Carcinoma Whose Cancers Have Not Progressed Following Definitive Concurrent Chemoradiotherapy",
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      "nct": "NCT04564482",
      "title": "PD-L1 PET Imaging During Neoadjuvant (Chemo)Radiotherapy in Esophageal and Rectal Cancer",
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      "study_type": "INTERVENTIONAL"
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      "nct": "NCT04665843",
      "title": "A Study of Atezolizumab Plus Tiragolumab and Atezolizumab Plus Placebo as First-Line Treatment in Participants With Recurrent/Metastatic PD-L1 Positive Squamous Cell Carcinoma of the Head and Neck",
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      "nct": "NCT04713891",
      "title": "A Study of KF-0210 in Advanced Solid Tumors Patients",
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      "nct": "NCT04939480",
      "title": "Window of Opportunity Study of Preoperative Immunotherapy With Atezolizumab in Local SCCHN",
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      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT05001347",
      "title": "A Clinical Study of TJ004309 With Atezolizumab (TECENTRIQ\u00ae) in Patients With Ovarian Cancer and Selected Solid Tumors",
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      "nct": "NCT05007613",
      "title": "Second-line Cabozantinib and Atezolizumab in Patients With Recurrent or Metastatic Esophageal Squamous Cell Carcinoma",
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      "nct": "NCT05053737",
      "title": "Radiotherapy in Combination With Atezolizumab Prior to Surgical Resection for HPV Unrelated HNSCC",
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      "nct": "NCT05063552",
      "title": "Testing the Use of Investigational Drugs Atezolizumab and/or Bevacizumab With or Without Standard Chemotherapy in the Second-Line Treatment of Advanced-Stage Head and Neck Cancers",
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     {
      "nct": "NCT05069935",
      "title": "FT538 in Combination With Monoclonal Antibodies in Advanced Solid Tumors",
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      "last_update": "2023-09-21",
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      "study_type": "INTERVENTIONAL"
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      "nct": "NCT05110781",
      "title": "Atezolizumab Before Surgery for the Treatment of Regionally Metastatic Head and Neck Squamous Cell Cancer With an Unknown or Historic Primary Site",
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      "nct": "NCT05222932",
      "title": "Oncolytic Adenovirus TILT-123 and Avelumab for Treatment of Solid Tumors Refractory to or Progressing After Anti-PD(L)1",
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     {
      "nct": "NCT05249426",
      "title": "A Study to Test Whether Different Combinations of BI 765063, Ezabenlimab, Chemotherapy, Cetuximab, and BI 836880 Help People With Head and Neck Cancer or Liver Cancer",
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      "last_update": "2026-07-07",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT05253053",
      "title": "To Evaluate Efficacy and Safety of TT-00420 (Tinengotinib) as Monotherapy and Combination Therapy in Patients With Advanced Solid Tumors",
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     {
      "nct": "NCT05259319",
      "title": "Study Evaluating the Safety and the Efficacy of Combination of Atezolizumab, Tiragolumab and and Stereotactic Body Radiation Therapy in Patients With Oligometastatic Multiorgan (IMMUNOs-SBRT)",
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      "nct": "NCT05395052",
      "title": "FT536 Monotherapy and in Combination With Monoclonal Antibodies in Advanced Solid Tumors",
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      "nct": "NCT05429866",
      "title": "Immunological Variables Associated to ICI Toxicity in Cancer Patients",
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      "last_update": "2023-03-08",
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     {
      "nct": "NCT05459129",
      "title": "A Study Evaluating Efficacy and Safety of Multiple Treatment Combinations in Patients With Locally Advanced Squamous Cell Carcinoma of the Head and Neck (Morpheus-Head and Neck Cancer)",
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     {
      "nct": "NCT05581004",
      "title": "A Study to Evaluate the Safety, Pharmacokinetics, and Activity of Enzelkitug as a Single Agent and in Combination With Checkpoint Inhibitor in Participants With Locally Advanced or Metastatic Solid Tumors",
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     {
      "nct": "NCT05655663",
      "title": "Evaluation of Vascular Toxicity of Immune Checkpoint Inhibitors in Patients Head and Neck or Lung Cancer",
      "status": "UNKNOWN",
      "last_update": "2022-12-19",
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      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT05681039",
      "title": "Phase 2 Trial of Neoadjuvant and Adjuvant Tiragolumab Plus Atezolizumab in Patients With Newly Diagnosed PD-L1 CPS Positive Resectable Stage 3-4 Oral Cavity Squamous Cell Carcinoma (OCSCC).",
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      "nct": "NCT06090318",
      "title": "Milademetan in Combination With Atezolizumab in Patients With Advanced Solid Tumors With CDKN2A Loss",
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     {
      "nct": "NCT07770100",
      "title": "Concurrent Immunotherapy and Systemic Therapy With Stereotactic Body Radiation Therapy (SBRT) for Stage IV Cancers (COINSSS IV)",
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      "last_update": "2026-08-20",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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      "title": "Cetuximab Plus Platinum and Taxane-based Chemotherapy, Followed by Avelumab and Cetuximab, as First-line Treatment for Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma (HNSCC) Patients With a PD-L1 Combined Positive Score (CPS)\u22651\u226419.",
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      "title": "A Study Of Avelumab In Combination With Other Cancer Immunotherapies In Advanced Malignancies (JAVELIN Medley)",
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      "title": "Study To Compare Avelumab In Combination With Standard of Care Chemoradiotherapy (SoC CRT) Versus SoC CRT for Definitive Treatment In Patients With Locally Advanced Squamous Cell Carcinoma Of The Head And Neck (JAVELIN HEAD AND NECK 100)",
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      "nct": "NCT05012098",
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      "title": "A Study to Assess the Adverse Events, Change in Disease Activity, and How Oral ABBV-711 Tablets Move Through the Body as a Monotherapy and in Combination With Intravenously Infused Budigalimab (ABBV-181), in Adults With Advanced Squamous Tumors",
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     {
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      "title": "A Study to Assess the Effects of Multiple Study Drug Regimens in Subjects With Newly Diagnosed Locally Advanced Head and Neck Squamous Cell Carcinoma",
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      "title": "Study to Determine the Safety, Tolerability, Pharmacokinetics and Recommended Phase 2 Dose (RP2D) of Livmoniplimab (ABBV-151) as a Single Agent and in Combination With Budigalimab (ABBV-181) in Participants With Locally Advanced or Metastatic Solid Tumors",
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      "title": "A Study to Assess the Safety, Pharmacokinetics, and Efficacy of Intravenous (IV) ABBV-303, as Monotherapy and in Combination With IV Infused Budigalimab (ABBV-181), in Adults With Advanced Solid Tumors",
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     {
      "nct": "NCT01852292",
      "title": "Study of Efficacy and Safety of Buparlisib (BKM120) Plus Paclitaxel Versus Placebo Plus Paclitaxel in Recurrent or Metastatic Head and Neck Cancer Previously Pre-treated With a Platinum Therapy",
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     {
      "nct": "NCT02113878",
      "title": "Phase Ib Study of BKM120 With Cisplatin and XRT in High Risk Locally Advanced Squamous Cell Cancer of Head and Neck",
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      "title": "The BURAN Study of Buparlisib in Patients With Recurrent or Metastatic HNSCC",
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     {
      "nct": "NCT06145308",
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     {
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      "title": "A Clinical Study on the Efficacy and Safety of Paclitaxel Polymeric Micelles and Cisplatin Combined With Cadonilimab as a Neoadjuvant Therapy for Locally Advanced Esophageal Squamous Cell Carcinoma",
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      "nct": "NCT05522894",
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      "title": "Cadonilimab (PD-1/CTLA-4 Bispecific Blockade) and Chemoradiotherapy in Nasopharyngeal Carcinoma (GEMSTONE)",
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      "last_update": "2025-01-23",
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     {
      "nct": "NCT05732662",
      "title": "SBRT Combined With AK104 to Treatment Relapsed or Metastatic ESCC",
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      "nct": "NCT05790200",
      "title": "Cadonilimab (AK104) in the Treatment of Nasopharyngeal Carcinoma",
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      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT05898256",
      "title": "Cadonilimab in the Treatment of Recurrent/Metastatic Nasopharyngeal Carcinoma",
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     {
      "nct": "NCT05990231",
      "title": "Cadonilimab/Anlotinib in Locally Advanced or Relapsed/Metastatic ESCC Patients After Failure of PD-1 Combined With Platinum-containing Chemotherapy",
      "status": "UNKNOWN",
      "last_update": "2023-09-11",
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      "nct": "NCT06023875",
      "title": "Neoadjuvant Cadonilimab in Combination With Cisplatin and Nab-paclitaxel in Resectable Head and Neck Squamous Cell Carcinoma",
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      "last_update": "2023-09-05",
      "phase": "PHASE2",
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     {
      "nct": "NCT06143748",
      "title": "Combination of Cadonilimab and Chemoradiotherapy in Esophageal Cancer (EC-CRT-006)",
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      "last_update": "2026-04-23",
      "phase": "PHASE2",
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     {
      "nct": "NCT06426797",
      "title": "Neoadjuvant Cadonilimab Combined With Anlotinib in Locally Advanced Resectable Esophageal Squamous Cell Carcinoma",
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      "last_update": "2024-05-23",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06681285",
      "title": "Cadonilimab Combined With Anlotinib Followed by Radiotherapy in Recurrent or Metastatic Esophageal Squamous Cell Carcinoma (CAR-RMEC)",
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      "last_update": "2024-11-08",
      "phase": "PHASE2",
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      "nct": "NCT03736863",
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      "title": "Efficacy and Safety of TPC+Apatinib+Camrelizumab vs GP+ Camrelizumab for High-Risk Nasopharyngeal Carcinoma: A Phase 3 Trial",
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      "nct": "NCT06675214",
      "title": "Under Whole-course of Immunotherapy, Gradient Fractionated RT with CCT Versus CFRT with CCT for LANPC Who Achieved PR Post Induction Chemotherapy.",
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      "title": "Two-cycle and Three-cycle Induction Therapy With Modified TPF Regimen Combined and Camrelizumab for LANPC",
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      "title": "A Multicenter Phase II Clinical Study of Neoadjuvant Use of Camrelizumab in Combination With Chemotherapy for Organ Preservation in Esophageal Cancer",
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      "title": "Combination Therapy for PD-1 Resistant Recurrent or Metastatic Nasopharyngeal Carcinoma: A Bayesian Adaptive Phase II Trial",
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      "nct": "NCT07162506",
      "title": "DCRT vs. Surgery in Resectable ESCC Patient Achiving cCR/PR After nCI",
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      "nct": "NCT07332247",
      "title": "PD-1 Inhibitor Plus Chemotherapy Followed by Immediate Versus Selective Re-irradiation for Locally Advanced Recurrent NPC",
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     {
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      "title": "Short-Course Definitive Chemoradiotherapy Combined With Adjuvant or Concurrent Plus Adjuvant Camrelizumab for Locally Advanced Unresectable Esophageal Squamous Cell Carcinoma",
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     {
      "nct": "NCT07662681",
      "title": "Camrelizumab With Famitinib for Patients With Rare Head and Neck Malignancies",
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      "last_update": "2026-06-23",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT03099382",
      "title": "Study of SHR-1210 Versus Investigator's Choice of Chemotherapy for Participants With Advanced Esophageal Cancer",
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      "last_update": "2024-01-22",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT03121716",
      "title": "A Study to Evaluate the Safety and Efficacy of SHR-1210, Gemcitabine and Cis-platinum by R/M NPC Subjects",
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      "phase": "PHASE1",
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     {
      "nct": "NCT03187314",
      "title": "Combination of Radiation Therapy and Anti-PD-1 Antibody SHR-1210 in Treating Patients With Esophageal Cancer",
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      "last_update": "2020-08-17",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT03222440",
      "title": "Combination of Radiotherapy and SHR-1210 to Treat Patients With ESCC",
      "status": "COMPLETED",
      "last_update": "2019-12-04",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03427827",
      "title": "PD-1 Antibody Versus Best Supportive Care After Chemoradiation in Locoregionally Advanced Nasopharyngeal Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2024-04-09",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT03558191",
      "title": "SHR-1210 in Recurrent/Metastatic Nasopharyngeal Carcinoma Who Have Received Previous At Least Two Lines of Chemotherapy.",
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      "last_update": "2024-03-15",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT03603756",
      "title": "SHR-1210 in Combination With Apatinib and Chemotherapy in Patients With Advanced Esophageal Squamous Cell Cancer",
      "status": "UNKNOWN",
      "last_update": "2020-02-11",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03671265",
      "title": "Combination of Chemotherapy Plus RT and SHR-1210 to Treat Patients With ESCC",
      "status": "UNKNOWN",
      "last_update": "2019-01-09",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03707509",
      "title": "Phase III Study of Camrelizumab in Combination With Chemotherapy in Recurrent/Metastatic Nasopharyngeal Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2022-07-01",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03766178",
      "title": "Study of Anti-PD-1 Antibody SHR-1210 Plus Nimotuzumab in the Treatment of Advanced Esophageal Squamous Cell Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2021-07-07",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03817658",
      "title": "A Phase II Study of SHR-1210 vs Placebo as Consolidation Chemotherapy After Radical Concurrent Chemoradiotherapy in Locally Advanced ESCC",
      "status": "UNKNOWN",
      "last_update": "2019-01-25",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04143984",
      "title": "Carbon-Ion Radiotherapy Plus Camrelizumab for Locally Recurrent Nasopharyngeal Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2022-04-29",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04156698",
      "title": "Induction Chemotherapy Combined With Immunotherapy for Locally Advanced Hypopharyngeal Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2023-08-09",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04221516",
      "title": "Camrelizumab After Completion of Radiotherapy for Oligometastatic Nasopharyngeal Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2023-06-18",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04225364",
      "title": "Efficacy of Neoadjuvant PD-1 Blockade Plus Chemotherapy for Esophageal Squamous Cell Carcinoma",
      "status": "COMPLETED",
      "last_update": "2021-02-02",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04286958",
      "title": "A Study of Camrelizumab As Consolidation Therapy After Radical Concurrent Chemoradiotherapy In Locally Advanced ESCC",
      "status": "UNKNOWN",
      "last_update": "2021-12-10",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04390945",
      "title": "Camrelizumab Combined With CRT for Treatment of Patients With Local Recurrence of Esophageal Cancer",
      "status": "UNKNOWN",
      "last_update": "2022-02-03",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04393506",
      "title": "Inductive Camrelizumab and Apatinib for Patients With Locally Advanced and Resectable Oral Squamous Cell Carcinoma",
      "status": "COMPLETED",
      "last_update": "2023-11-22",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04399785",
      "title": "Phase II Study for Combination of Camrelizumab and SBRT in the First-line Treatment for R/M HNSCC",
      "status": "UNKNOWN",
      "last_update": "2020-05-22",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04405154",
      "title": "A Study of Concomitant Camrelizumab With Chemoradiation for Locally Advanced Head and Neck Cancer",
      "status": "UNKNOWN",
      "last_update": "2020-05-28",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04426955",
      "title": "Study of Camrelizumab (SHR-1210) in Combination With Concurrent Chemoradiotherapy in Locally Advanced Esophageal Cancer",
      "status": "UNKNOWN",
      "last_update": "2021-09-16",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04440917",
      "title": "Camrelizumab Combined With Apatinib Mesylate for Head and Neck Squamous Cell Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2021-02-02",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04506138",
      "title": "Camrelizumab in Combination With Neoadjuvant Chemotherapy for Resectable Thoracic Esophageal Squamous Cell Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2021-12-14",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04510818",
      "title": "Combination of Metronomic Capecitabine With Camrelizumab for Treatment of Refractory Solid Tumor Trial (Cohort 2)",
      "status": "UNKNOWN",
      "last_update": "2020-08-14",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04512417",
      "title": "A Clinical Study Of Camrelizumab With Or Without Radiotherapy In The Treatment Of Esophageal Cancer",
      "status": "UNKNOWN",
      "last_update": "2020-08-13",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04539600",
      "title": "Induction Chemotherapy Combined With Camrelizumab in Locoregionally Advanced Hypopharyngeal Cancer",
      "status": "UNKNOWN",
      "last_update": "2021-08-19",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04547088",
      "title": "Camrelizumab Combined With Apatinib in Patients With First-line Platinum-resistant Recurrent/Metastatic Nasopharyngeal Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2020-09-14",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04548271",
      "title": "Camrelizumab Combined With Apatinib in Patients With PD-1 Antagonists Resistant Recurrent/Metastatic Nasopharyngeal Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2020-09-14",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04586088",
      "title": "Apatinib and Camrelizumab in Recurrent or Metastatic Nasopharyngeal Carcinoma With First-line Treatment Failure",
      "status": "UNKNOWN",
      "last_update": "2023-05-06",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04612894",
      "title": "Camrelizumab and Apatinib for Neoadjuvant Therapy in Thyroid Cancer",
      "status": "UNKNOWN",
      "last_update": "2020-11-03",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04649476",
      "title": "Neoadjuvant PD-1 Blockade in Resectable Oral Squamous Cell Carcinoma",
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      "last_update": "2025-01-10",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04654403",
      "title": "Study of First-line Camrelizumab With or Without Chemotherapy for Advanced Esophageal Squamous Cell Cancer",
      "status": "UNKNOWN",
      "last_update": "2021-08-23",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04767295",
      "title": "A Study of Camrelizumab Combined With Chemotherapy as Neoadjuvant Therapy in Adcanced Esophageal Squamous Cell Carcinoma (ESCC)",
      "status": "UNKNOWN",
      "last_update": "2021-02-23",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04826679",
      "title": "Neoadjuvant Camrelizumab in Combination With Cisplatin and Nab-paclitaxel in Resectable HNSCC",
      "status": "UNKNOWN",
      "last_update": "2021-04-01",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04830267",
      "title": "The Efficacy of Camrelizumab Plus Stereotactic Body Radiotherapy in R/M NPC",
      "status": "UNKNOWN",
      "last_update": "2024-03-28",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04861467",
      "title": "Camrelizumab as a Maintenance Therapy After Chemoradiation in Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2021-04-27",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04866381",
      "title": "An Exploratory Clinical Study of SHR6390 and SHR1020 in the Treatment of Esophageal Squamous Cell Carcinoma After Progression on PD-1 Antibody",
      "status": "UNKNOWN",
      "last_update": "2021-04-29",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04922450",
      "title": "Clinical Study of Camrelizumab in Combination With Neoadjuvant Chemotherapy for Operable Locally Advanced Head and Neck Squamous Cell Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2021-06-10",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04978012",
      "title": "Fluzoparib and Camrelizumab in Treating Patients With R/M NPC That Progressed After First-line Chemotherapy",
      "status": "UNKNOWN",
      "last_update": "2022-06-07",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04984018",
      "title": "Chidamide Plus Camrelizumab as Second-line Therapy for Advanced ESCC Treated With PD-1 Blockade",
      "status": "UNKNOWN",
      "last_update": "2021-07-30",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05011227",
      "title": "Camrelizumab and Chemotherapy Combined With Endoscopic Surgery for Recurrent Nasopharyngeal Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2024-03-06",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05049681",
      "title": "Study of Anti-PD-1 Antibody SHR-1210 Plus Apatinib vs SHR-1210 as Second-Line Treatment of Advanced Esophageal Squamous Cell",
      "status": "UNKNOWN",
      "last_update": "2021-09-20",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05097209",
      "title": "Camrelizumab for the Treatment of Locally Advanced Nasopharyngeal Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2023-03-23",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05114707",
      "title": "Camrelizumab Plus Chemoradiotherapy for Patients With Locoregional Cancer of Nasal Cavity and Paranasal Sinuses",
      "status": "UNKNOWN",
      "last_update": "2021-11-10",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05156970",
      "title": "Camrelizumab in Combination With Chemotherapy or Apatinib Mesylate as First-Line Treatment for R/M HNSCC",
      "status": "COMPLETED",
      "last_update": "2025-07-31",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05176002",
      "title": "Camrelizumab in Combination With Radiotherapy for Neoadjuvant Esophageal Carcinoma.",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-11-19",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05183958",
      "title": "A Multicenter, Randomized Controlled, Phase II Clinical Study of First-line Chemotherapy and Camrelizumab With or Without Radiotherapy in the Treatment of Oligometastatic Esophageal Cancer",
      "status": "UNKNOWN",
      "last_update": "2022-01-11",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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      "nct": "NCT05189184",
      "title": "Study of Camrelizumab in Combination With Apatinib Mesylate Plus Albumin-bound Paclitaxel and Cisplatin as the First Line Treatment of Recurrent or Metastatic, UnresectableHead and Neck Squamous Cell Carcinoma",
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      "title": "Neoadjuvant Therapy of PD-1 Blockade Combined With Chemotherapy for Esophageal Carcinoma",
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      "title": "Fruquintinib as First Line Treatment in Patients With Recurrent Esophageal Squamous Cell Carcinoma",
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      "title": "A Clinical Study of Chemoradiotherapy Sequential Fluzoparib in Pan-solid Tumors",
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      "title": "Thalidomide Prevention or Treatment of Camrelizumab-induced Reactive Cutaneous Capillary Endothelial Proliferation (RCCEP)",
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      "title": "Camrelizumab Combined With EGFR Monoclonal Antibody or Chemotherapy for Perioperative Treatment of Locally Advanced Head and Neck Squamous Cell Carcinoma",
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      "title": "Testing Whether Cemiplimab (REGN2810) Plus CDX-1140 Given Prior to Surgery Are Better Than Cemiplimab (REGN2810) Alone in Patients With Stage III-IV Head and Neck Cancer",
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      "nct": "NCT07179315",
      "title": "A Study Comparing Two Immunotherapy Options for Human Papillomavirus Positive HPV-Positive Head and Neck Cancer After Treatment",
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      "title": "Intratumoral Cavrotolimod Combined With Pembrolizumab or Cemiplimab in Patients With Merkel Cell Carcinoma, Cutaneous Squamous Cell Carcinoma, or Other Advanced Solid Tumors",
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      "title": "Phase 2 Trial of Voyager V1 in Combination With Cemiplimab in Cancer Patients",
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      "title": "An Open-label Study Using ASP-1929 Photoimmunotherapy in Combination With Anti-PD1 Therapy in EGFR Expressing Advanced Solid Tumors",
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      "title": "Phase 2 Trial of Maintenance Cemiplimab for Head and Neck Squamous Cell Carcinoma (HNSCC)",
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      "title": "A Trial To Find Out If Vidutolimod Together With Cemiplimab Is Safe And If It Works In Adult Participants With Advanced Cancer Or Metastatic Cancer",
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      "title": "A Study of OR2805, a Monoclonal Antibody Targeting CD163, Alone and in Combination With Anticancer Agents",
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      "title": "Glycan Mediated Immune Regulation With a Bi-Sialidase Fusion Protein (GLIMMER-01)",
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      "phase": "PHASE1/PHASE2",
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      "nct": "NCT05429866",
      "title": "Immunological Variables Associated to ICI Toxicity in Cancer Patients",
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      "last_update": "2023-03-08",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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      "title": "Phase 2 Study of Neoadjuvant SAR444245 Plus Cemiplimab in HPV Related Oropharynx Squamous Cell Carcinoma",
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      "title": "A Study of SNS-101 (Anti VISTA) Monotherapy and in Combination With Cemiplimab in Patients With Advanced Solid Tumors",
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      "nct": "NCT05878288",
      "title": "Deep sequencIng in Cutaneous Squamous CEll caRciNomas",
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      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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      "nct": "NCT05929664",
      "title": "Cemiplimab Plus Fianlimab for the Treatment of Locally Advanced Head and Neck Basal Cell Carcinoma Before Surgery",
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      "last_update": "2026-06-10",
      "phase": "PHASE2",
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      "nct": "NCT06052852",
      "title": "Study of BDC-3042 as Single Agent and in Combination With Cemiplimab in Patients With Advanced Malignancies",
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      "phase": "PHASE1",
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      "nct": "NCT06568172",
      "title": "Testing the Addition of an Immunotherapy Drug, Cemiplimab (REGN2810), Plus Surgery to the Usual Surgery Alone for Treating Advanced Skin Cancer",
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      "last_update": "2026-09-01",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
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      "nct": "NCT06855212",
      "title": "Phase II Study of Neoadjuvant Cetuximab and Cemiplimab in Patients Undergoing Surgery for HNSCC",
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      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00122460",
      "title": "Cetuximab (Erbitux) in Combination With Cisplatin or Carboplatin and 5-Fluorouracil in the First Line Treatment of Subjects With Recurrent and/or Metastatic Squamous Cell Carcinoma of the Head and Neck (EXTREME)",
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      "nct": "NCT00165490",
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     {
      "nct": "NCT00226239",
      "title": "Docetaxel, Cetuximab and Cisplatin Followed by Radiation, Cetuximab and Cisplatin in Head and Neck Cancer",
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      "nct": "NCT00251381",
      "title": "Cetuximab & Concomitant-Boost Accelerated RT in Patients With Locally Advanced Oropharynx Squamous Cell Carcinoma.",
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      "nct": "NCT00291707",
      "title": "Trial of Cetuximab and Pemetrexed With Radiation in Head and Neck Cancer",
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     {
      "nct": "NCT00343083",
      "title": "Evaluation of Cetuximab (ERBITUX) and Concurrent Carboplatin, Paclitaxel & Radiotherapy in the Management of Patients With Advanced Locoregional Squamous Cell Carcinomas of the Head and Neck (GCC 0442)",
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      "title": "Combination Chemotherapy and Cetuximab in Treating Patients With Metastatic Esophageal Cancer or Gastroesophageal Junction Cancer",
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     {
      "nct": "NCT00397904",
      "title": "Cetuximab, Cisplatin, and Irinotecan in Treating Patients With Metastatic Esophageal Cancer, Gastroesophageal Junction Cancer, or Gastric Cancer That Did Not Respond to Previous Irinotecan and Cisplatin",
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      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00409565",
      "title": "A Phase II Trial of Cetuximab and Bevacizumab in Patients With Recurrent or Metastatic Head and Neck Cancer",
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      "last_update": "2017-10-20",
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      "title": "Cetuximab, Oxaliplatin, Fluorouracil, and Radiation Therapy in Treating Patients With Stage II or Stage III Esophageal Cancer",
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      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00439608",
      "title": "Cetuximab, Paclitaxel, Carboplatin & Radiation for Esoph, Gastroesoph & Gastric Cancer",
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     {
      "nct": "NCT00502463",
      "title": "Induction Chemotherapy Prior to Radio-immunotherapy in Head and Neck Cancer Stage III/IV - a Methodical Trial",
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      "study_type": "INTERVENTIONAL"
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      "title": "Cisplatin, Capecitabine, and Radiation Therapy With or Without Cetuximab in Treating Patients With Esophageal Cancer",
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      "phase": "PHASE2/PHASE3",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00524017",
      "title": "Cetuximab in Treating Patients With Precancerous Lesions of the Upper Aerodigestive Tract",
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      "last_update": "2020-03-12",
      "phase": "PHASE2",
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     {
      "nct": "NCT00591149",
      "title": "Oxaliplatin and Docetaxel Followed by Cetuximab for Head and Neck Cancer",
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      "last_update": "2017-06-14",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00599131",
      "title": "Cetuximab and Radiation Therapy in Laryngeal Cancer Patients Who Have Responded to One Cycle of Chemotherapy (SPORE)",
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      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00609284",
      "title": "Randomized Trial of Concomitant Chemotherapy in Patients With Locally Advanced HNSCC Treated by Radiotherapy-erbitux",
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      "last_update": "2020-04-15",
      "phase": "PHASE3",
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     {
      "nct": "NCT00622674",
      "title": "Bortezomib and Cetuximab in Treating Patients With Advanced Solid Tumors",
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      "last_update": "2017-12-02",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00660218",
      "title": "A Phase I/II Study of Radiation Therapy, Paclitaxel Poliglumex and Cetuximab in Advanced Head and Neck Cancer",
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      "last_update": "2021-11-08",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00661427",
      "title": "Cetuximab at Either 500 or 750 mg/m2 Every Other Week for Recurrent or Metastatic Head and Neck Squamous Cell Cancer",
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      "last_update": "2018-01-11",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00665392",
      "title": "Cetuximab and Combination Chemotherapy in Patients With Stage III-IV Resectable Oropharynx Cancer",
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      "last_update": "2025-08-01",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00671437",
      "title": "Determine Tumor Response Using Fluorodeoxyglucose (FDG)- Positron Emission Tomography (PET)/Computed Tomography (CT) Before and After Cetuximab in Patients With Head and Neck Cancer",
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      "last_update": "2017-03-14",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00704639",
      "title": "Chemoradiation Treatment for Head and Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2017-07-12",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00705016",
      "title": "Cilengitide in Recurrent and/or Metastatic Squamous Cell Carcinoma of the Head and Neck (SCCHN)",
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      "last_update": "2014-04-30",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00713219",
      "title": "Docetaxel + Cetuximab + Concurrent Re-Irradiation (Intensity - Modulated Radiation Therapy, IMRT) for Patients With Locoregionally Recurrent Head and Neck Cancer",
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      "last_update": "2015-04-23",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00714649",
      "title": "Neoadjuvant Cetuximab in HNSCC Combined With Curative Surgery",
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      "last_update": "2012-11-14",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00735345",
      "title": "Chemotherapy Induction and Chemoradiotherapy in Patients With Esophageal Carcinoma",
      "status": "TERMINATED",
      "last_update": "2015-03-09",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00736944",
      "title": "Trial of 2 Cycles of Induction Chemo With Abraxane, Cetuximab, Cisplatin, & 5-FU for Advanced Head and Neck Cancer",
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      "last_update": "2020-09-09",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00738868",
      "title": "Cetuximab and Stereotactic Radiation Therapy in Treating Patients With Recurrent Head and Neck Cancer That Cannot Be Removed By Surgery",
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      "last_update": "2011-05-13",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00765011",
      "title": "TPF Plus Radiotherapy and Cetuximab to Avoid Total Laryngectomy in Patients With Larynx Cancer",
      "status": "COMPLETED",
      "last_update": "2019-04-11",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00820417",
      "title": "Pharmocokinetic/Pharmacodynamic (PK/PD) Study of the Combination Cetuximab/Gefitinib",
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      "last_update": "2009-01-12",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00833261",
      "title": "Nab-Paclitaxel, Cetuximab, Cisplatin, and Radiation Therapy in Treating Patients With Recurrent Head and Neck Cancer",
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      "last_update": "2020-08-21",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00851877",
      "title": "Nab-Paclitaxel, Cisplatin, and Cetuximab With Concurrent Radiation Therapy for Locally Advanced Head and Neck Cancer",
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      "last_update": "2020-08-21",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00868491",
      "title": "Induction Chemotherapy Followed by Chemoradiation With Cetuximab in Head and Neck Cancer",
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      "last_update": "2024-10-18",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00891904",
      "title": "Radiation Therapy and Cetuximab in Treating Patients With Recurrent Head and Neck Cancer",
      "status": "TERMINATED",
      "last_update": "2016-04-14",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00906360",
      "title": "Sunitinib, Cetuximab, and Radiation Therapy in Treating Patients With Locally Advanced or Recurrent Squamous Cell Carcinoma of the Head and Neck",
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      "last_update": "2013-07-02",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00908024",
      "title": "Combination Study of BMS-754807 and Erbitux\u00ae in Subjects With Advanced or Metastatic Solid Tumors",
      "status": "TERMINATED",
      "last_update": "2013-06-18",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00933387",
      "title": "A Study of Neoadjuvant Bio-C/T Followed by Concurrent Bio-R/T in High-risk Locally Advanced Oral Squamous Cell Carcinoma",
      "status": "COMPLETED",
      "last_update": "2016-05-04",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00934518",
      "title": "Image Guided Intensity Modulated Reirradiation (IG-IMRT) With Cetuximab for Locoregionally Confined Recurrent Head and Neck Squamous Cell Carcinoma",
      "status": "WITHDRAWN",
      "last_update": "2019-02-12",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00939627",
      "title": "Phase II Randomized Trial of the Combination of Cetuximab and Sorafenib or Single Agent Cetuximab",
      "status": "COMPLETED",
      "last_update": "2026-03-10",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00956007",
      "title": "RT With or Without Cetuximab in Treating Patients Who Have Undergone Surgery for Locally Advanced Head and Neck Cancer",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-01-06",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00957853",
      "title": "Preoperative Treatment With Cetuximab and/or IMC-A12",
      "status": "COMPLETED",
      "last_update": "2020-03-19",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00968435",
      "title": "Bevacizumab, Cetuximab, and Cisplatin With IMRT (Intensity-Modulated Radiation Therapy) for Patients With Stage III/IV Head and Neck Squamous Cell Carcinoma",
      "status": "COMPLETED",
      "last_update": "2016-08-10",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01009346",
      "title": "RAD001 in Combination With Cetuximab and Cisplatin in Recurrent and Metastatic SCCHN",
      "status": "TERMINATED",
      "last_update": "2018-07-17",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT01015664",
      "title": "Combination of Cisplatin, Cetuximab and Temsirolimus in Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck",
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      "last_update": "2012-12-17",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT01034189",
      "title": "Cetuximab/Paclitaxel/Cisplatin Concurrent Chemoradiotherapy Followed by Esophagectomy for Loco-regional Esophageal Cancer",
      "status": "UNKNOWN",
      "last_update": "2009-12-17",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT01081041",
      "title": "A Study in Head and Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2019-09-25",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT01087970",
      "title": "A Study for Participants With Recurrent or Metastatic Squamous Cell Head and Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2014-05-19",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01099358",
      "title": "Study in Advanced Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2019-09-26",
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     {
      "nct": "NCT01133665",
      "title": "Cetuximab and Lenalidomide in Head and Neck",
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      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT01166035",
      "title": "Lenalidomide and Cetuximab in Patients With Advanced Solid Tumors",
      "status": "UNKNOWN",
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      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01177956",
      "title": "A Trial to Determine the Safety and Anti-tumor Activity Profile of the Combination of Cetuximab and Concomitant Cisplatin Plus 5-Fluorouracil (5-FU) in Subjects With Recurrent and/or Metastatic Squamous Cell Carcinoma in Head and Neck",
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     },
     {
      "nct": "NCT01181401",
      "title": "InductionChemo-Radio-Antibody-Treatment",
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      "last_update": "2019-01-31",
      "phase": "PHASE2",
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     },
     {
      "nct": "NCT01212627",
      "title": "Ridaforolimus With Cetuximab: Adv Non-Small Cell Lung, Colorectal, Head & Neck Cancer",
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      "last_update": "2021-02-16",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01216020",
      "title": "Cetuximab Plus Radiotherapy Versus Cisplatin Plus Radiotherapy in Locally Advanced Head and Neck Cancer",
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      "last_update": "2018-01-17",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01218048",
      "title": "ERBITUX\u00ae Followed by Adjuvant Treatment With Chemoradiation and ERBITUX\u00ae for Locally Advanced Head and Neck Squamous Cell Carcinoma",
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      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01221753",
      "title": "Docetaxel/Cisplatin/5-Fluorouracil (TPF) Human Papillomavirus (HPV) Squamous Cell Carcinoma Study",
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      "last_update": "2017-12-06",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01230476",
      "title": "Induction and Concurrent Chemoradiotherapy With Cetuximab for Patients With Locally Advanced Nasopharyngeal Carcinoma",
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      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT01252628",
      "title": "Phase 1 and 2 Study of PX-866 and Cetuximab",
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      "last_update": "2018-05-16",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT01254617",
      "title": "Lenalidomide and Cetuximab in Treating Patients With Advanced Colorectal Cancer or Head and Neck Cancer",
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      "last_update": "2020-03-13",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01255800",
      "title": "Pilot Study of Cetuximab and the Hedgehog Inhibitor IPI-926 in Recurrent Head and Neck Cancer",
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      "last_update": "2014-01-31",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01262859",
      "title": "Pilot Study for Locally Advanced Head and Neck Cancer",
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      "last_update": "2014-01-13",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01301248",
      "title": "Cisplatin Chemoradiation With or Without Cetuximab for Locoregionally Advanced Squamous Cell Carcinomas (SCC) of the Head and Neck",
      "status": "UNKNOWN",
      "last_update": "2011-05-17",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01302834",
      "title": "Radiation Therapy With Cisplatin or Cetuximab in Treating Patients With Oropharyngeal Cancer",
      "status": "COMPLETED",
      "last_update": "2026-07-20",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01316757",
      "title": "Carboplatin, Paclitaxel, Cetuximab, and Erlotinib Hydrochloride in Treating Patients With Metastatic or Recurrent Head and Neck Squamous Cell Cancer",
      "status": "COMPLETED",
      "last_update": "2018-02-26",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01326468",
      "title": "Torisel in Addition to Standard Chemotherapy With Radiation for Advanced Head and Neck Cancer",
      "status": "WITHDRAWN",
      "last_update": "2025-09-25",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01326923",
      "title": "Induction Chemo Then Concurrent Chemoradiotherapy With Cetuximab in Locally Advanced Head and Neck Squamous Cell Cancer",
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      "last_update": "2020-10-09",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01332266",
      "title": "E7050 in Combination With Cetuximab Versus Cetuximab Alone in the Treatment of Platinum-Resistant Squamous Cell Carcinoma of the Head and Neck",
      "status": "COMPLETED",
      "last_update": "2022-01-03",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01434394",
      "title": "Neoadjuvant Erbitux Based Chemotherapy for Locally Advanced Oral/Oropharyngeal Cancer",
      "status": "COMPLETED",
      "last_update": "2017-08-21",
      "phase": "PHASE2/PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01437449",
      "title": "Docetaxel, Cisplatin, and Cetuximab (TPC) in Palliative Treatment of Patients With Squamous Cell Carcinoma of the Head and Neck (SCCHN)",
      "status": "COMPLETED",
      "last_update": "2024-01-30",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01440270",
      "title": "Neo-adjuvant Erbitux-based Chemotherapy for Locally Advanced Oral/Oropharyngeal Cancer",
      "status": "COMPLETED",
      "last_update": "2020-05-05",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01445405",
      "title": "Radiation Therapy and Bortezomib and Cetuximab With or Without Cisplatin to Treat Head and Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2019-12-17",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01451632",
      "title": "A Safety Study of MM-121 With Cetuximab and Irinotecan in Patients With Advanced Cancers",
      "status": "COMPLETED",
      "last_update": "2016-09-08",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01472653",
      "title": "Treatment Selection According to Skin Reaction to Cetuximab",
      "status": "UNKNOWN",
      "last_update": "2011-12-13",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01488318",
      "title": "Cetuximab and Dasatinib in Recurrent Squamous Cell Carcinoma",
      "status": "TERMINATED",
      "last_update": "2018-01-05",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01540682",
      "title": "MLN8237 in Head and Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2018-08-29",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01553032",
      "title": "Skin Changes in Head and Neck Cancer During Immuno-(Chemo-) And Radiotherapy With Erbitux\u00ae (HICARE)",
      "status": "COMPLETED",
      "last_update": "2022-05-25",
      "phase": "PHASE4",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01566435",
      "title": "Induction Chemotherapy With ACF Followed by Chemoradiation Therapy for Adv. Head & Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2020-10-01",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01581970",
      "title": "Potentiation of Cetuximab by Tregs Depletion With CSA in Advanced Head & Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2019-09-11",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01602315",
      "title": "A Phase Ib/II Study of BYL719 and Cetuximab in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma",
      "status": "TERMINATED",
      "last_update": "2020-12-29",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01637194",
      "title": "Cetuximab and Everolimus in Treating Patients With Metastatic or Recurrent Colon Cancer or Head and Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2012-07-11",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01663259",
      "title": "Reduced-intensity Therapy for Oropharyngeal Cancer in Non-smoking HPV-16 Positive Patients",
      "status": "COMPLETED",
      "last_update": "2021-01-19",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01693159",
      "title": "Effects of ECA on Quality of Life in Head and Neck Cancer Patients Suffering From Cetuximab-induced Rhagades",
      "status": "UNKNOWN",
      "last_update": "2017-09-25",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01737450",
      "title": "Activity and Safety Study of BKM120 in Monotherapy in Patient With Metastatic Head and Neck Cancer Recurrent or Progressive",
      "status": "COMPLETED",
      "last_update": "2019-06-24",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01744340",
      "title": "A Dose Finding Study of Eribulin Mesylate and Cetuximab For Patients With Advanced Head and Neck and Colon Cancer",
      "status": "COMPLETED",
      "last_update": "2020-02-17",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01758731",
      "title": "Study of Olaparib With Radiation Therapy and Cetuximab in Advanced Head and Neck Cancer With Heavy Smoking History",
      "status": "COMPLETED",
      "last_update": "2019-09-23",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01787006",
      "title": "Definitive Radiochemotherapy Plus/Minus Cetuximab in Unresectable Locally Advanced Esophageal Cancer",
      "status": "COMPLETED",
      "last_update": "2020-03-10",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01790516",
      "title": "Use of Pharmacogenetics to Select Erbitux or Cisplatin to Treat Head and Neck Cancer",
      "status": "TERMINATED",
      "last_update": "2014-10-02",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01810913",
      "title": "Testing Docetaxel-Cetuximab or the Addition of an Immunotherapy Drug, Atezolizumab, to the Usual Chemotherapy and Radiation Therapy in High-Risk Head and Neck Cancer",
      "status": "SUSPENDED",
      "last_update": "2026-09-01",
      "phase": "PHASE2/PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01836029",
      "title": "Chemotherapy Plus Cetuximab in Combination With VTX-2337 in Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck",
      "status": "COMPLETED",
      "last_update": "2019-10-29",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01864772",
      "title": "Phase II Trial of Carboplatin, 5-FU and Cetuximab in Elderly Fit (no Frailty) Patients With Recurrent/Metastatic HNSCC",
      "status": "COMPLETED",
      "last_update": "2022-08-19",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01874171",
      "title": "Determination of Cetuximab Versus Cisplatin Early and Late Toxicity Events in HPV+ OPSCC",
      "status": "UNKNOWN",
      "last_update": "2017-05-08",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01884259",
      "title": "Induction Chemotherapy With TP+5-FU or TP+Cetuximab Followed by Radioimmuptherapy for Locally Advanced or Not Resectable SCCHNN",
      "status": "COMPLETED",
      "last_update": "2022-05-26",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01884623",
      "title": "Phase III Trial Comparing Methotrexate and Cetuximab in First-line Treatment of Recurrent and/or Metastatic Squamous Cell Head and Neck Cancer",
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      "last_update": "2024-02-09",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01931150",
      "title": "Study of Prophylactic Topical Dapsone 5% Gel Versus Moisturizer for Cetuximab-induced Papulopustular (Acneiform) Rash in Patients With mCRC or HNSCC Without Previous or Concurrent RT",
      "status": "COMPLETED",
      "last_update": "2017-01-13",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01969877",
      "title": "A Study of Cisplatin Plus Radiotherapy Compared to Cetuximab Plus Radiotherapy in Locally Advanced Head and Neck Cancer.",
      "status": "COMPLETED",
      "last_update": "2020-09-02",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01979211",
      "title": "Post-operative Radiation With Cetuximab for Locally Advanced Cutaneous Squamous Cell Carcinoma of the Head and Neck",
      "status": "COMPLETED",
      "last_update": "2024-02-29",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02054442",
      "title": "A Study of the Combination of Cetuximab and Methotrexate in Recurrent or Metastatic Cancer of the Head and Neck",
      "status": "UNKNOWN",
      "last_update": "2021-03-12",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02057107",
      "title": "SBRT With Cetuximab +/- Docetaxel Followed by Adjuvant Cetuximab +/- Docetaxel in Recurrent, Previously-Irradiated SCCHN",
      "status": "COMPLETED",
      "last_update": "2023-06-05",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02110082",
      "title": "Combination Study of Urelumab and Cetuximab in Patients With Advanced/Metastatic Colorectal Cancer or Advanced/Metastatic Head and Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2017-04-19",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02124707",
      "title": "Weekly Carboplatin, Paclitaxel and Cetuximab Treatment for Patients With Recurrent or Metastatic SCCHN",
      "status": "COMPLETED",
      "last_update": "2020-08-12",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02124850",
      "title": "A Phase Ib Study of Neoadjuvant of Cetuximab Plus Motolimod and Cetuximab Plus Motolimod Plus Nivolumab",
      "status": "TERMINATED",
      "last_update": "2019-10-25",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02177838",
      "title": "Cetuximab and Radiation Therapy in Treating Patients With Stage III-IV Head and Neck Cancer",
      "status": "TERMINATED",
      "last_update": "2021-04-21",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02281955",
      "title": "De-intensification of Radiation and Chemotherapy for Low-Risk HPV-related Oropharyngeal SCC: Follow-up Study",
      "status": "COMPLETED",
      "last_update": "2025-01-07",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02282371",
      "title": "Cetuximab + BYL719 + IMRT (Intensity-Modulated Radiation Therapy) in Stage III/IVB Head and Neck Squamous Cell Cancer (HNSCC)",
      "status": "COMPLETED",
      "last_update": "2021-10-26",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02318901",
      "title": "Pembrolizumab and Monoclonal Antibody Therapy in Advanced Cancer",
      "status": "TERMINATED",
      "last_update": "2019-10-21",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02358031",
      "title": "A Study of Pembrolizumab (MK-3475) for First Line Treatment of Recurrent or Metastatic Squamous Cell Cancer of the Head and Neck (MK-3475-048/KEYNOTE-048)",
      "status": "COMPLETED",
      "last_update": "2025-07-18",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02429089",
      "title": "Study of LEE011plus Cetuximab in Patients With a Cancer of the Head and Neck",
      "status": "TERMINATED",
      "last_update": "2020-01-09",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02438995",
      "title": "Super-Selective Intraarterial Infusion of Cetuximab (Erbitux) With or Without Radiation Therapy for the Treatment of Unresectable Recurrent Squamous Cell Carcinoma of the Head and Neck",
      "status": "TERMINATED",
      "last_update": "2021-11-03",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02507154",
      "title": "Reactivating NK Cells in Treating Refractory Head and Neck Cancer",
      "status": "UNKNOWN",
      "last_update": "2018-08-21",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02555644",
      "title": "A Study of Prexasertib (LY2606368) With Chemotherapy and Radiation in Participants With Head and Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2019-02-15",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02627274",
      "title": "A Study Evaluating Safety, Pharmacokinetics, and Therapeutic Activity of RO6874281 as a Single Agent (Part A) or in Combination With Trastuzumab or Cetuximab (Part B or C)",
      "status": "COMPLETED",
      "last_update": "2022-11-22",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02633176",
      "title": "Cisplatin Plus Docetaxel Versus Cetuximab, Cisplatin, and Docetaxel in Metastatic Nasopharyngeal Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2015-12-17",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02633800",
      "title": "Patritumab With Cetuximab and a Platinum Agent for Squamous Cell Carcinoma (Cancer) of the Head and Neck (SCCHN )",
      "status": "TERMINATED",
      "last_update": "2019-01-07",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02636088",
      "title": "Definitive Chemoradiotherapy and Cetuximab in the Treatment of Locally Advanced Esophageal Cancer",
      "status": "UNKNOWN",
      "last_update": "2018-09-21",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02707588",
      "title": "Tolerance and Efficacy of Pembrolizumab or Cetuximab Combined With RT in Patients With Locally Advanced HNSCC",
      "status": "COMPLETED",
      "last_update": "2023-02-28",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02764593",
      "title": "Safety Testing of Adding Nivolumab to Chemotherapy in Patients With Intermediate and High-Risk Local-Regionally Advanced Head and Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2022-11-29",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02817113",
      "title": "Study of NC-6004 in Combination With 5-FU and Cetuximab in Patients With Head and Neck Cancer",
      "status": "TERMINATED",
      "last_update": "2021-04-30",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02938273",
      "title": "Bioimmunoradiotherapy (Cetuximab/RT/Avelumab)",
      "status": "COMPLETED",
      "last_update": "2019-12-11",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03024489",
      "title": "Palbociclib With Cetuximab and IMRT for Locally Advanced Squamous Cell Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2024-03-15",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03051906",
      "title": "Durvalumab, Cetuximab and Radiotherapy in Head Neck Cancer",
      "status": "UNKNOWN",
      "last_update": "2017-11-22",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03067610",
      "title": "Involved Field Elective Volume De-Intensification Radiation Therapy for Head and Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2022-03-17",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03070366",
      "title": "Stereotactic Radiotherapy Combined With Chemotherapy or Not for Treatment of Oligometastases in HNSCC",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-09-02",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03088059",
      "title": "Biomarker-based Study in R/M SCCHN",
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      "title": "A Study of CDX-3379 and Cetuximab and in Patients With Advanced Head and Neck Squamous Cell Carcinoma",
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      "nct": "NCT03319459",
      "title": "FATE-NK100 as Monotherapy and in Combination With Monoclonal Antibody in Subjects With Advanced Solid Tumors",
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      "nct": "NCT03349710",
      "title": "Nivolumab or Nivolumab Plus Cisplatin, in Combination With Radiotherapy in Patients With Cisplatin-ineligible or Eligible Locally Advanced Squamous Cell Head and Neck Cancer",
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     {
      "nct": "NCT03386838",
      "title": "An Immuno-therapy Study of Nivolumab in Combination With Experimental Medication BMS-986205 Compared to Standard of Care EXTREME Regimen in First-line Recurrent/Metastatic Squamous Cell Carcinoma of Head and Neck",
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      "nct": "NCT03422536",
      "title": "Ficlatuzumab w/wo Cetuximab in Patients w/Cetuximab-Resistant, Recurrent or Metastatic Head/Neck Squamous Cell Carcinoma",
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     {
      "nct": "NCT03498378",
      "title": "Avelumab, Cetuximab, and Palbociclib in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma",
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      "title": "Testing Lenvatinib and Cetuximab in Patients With Advanced Head and Neck Squamous Cell Carcinoma and Cutaneous Squamous Cell Carcinoma",
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      "title": "Concomitant Immune Check Point Inhibitor With Radiochemotherapy in Head And Neck Cancer",
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      "title": "Paclitaxel vs Paclitaxel + Cetuximab in Recurrent - Metastatic Head & Neck Carcinoma After Failure of a 1\u00ba Chemotherapy",
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      "title": "sEphB4-HSA With RT+Chemo or Cetux in Patients With Intermediate to High Risk LAHNSCC",
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      "title": "Radiation Therapy and Cisplatin With or Without Cetuximab in Treating Patients With HPV Positive, KRAS-Variant Stage III-IV Oropharyngeal Squamous Cell Carcinoma",
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      "title": "Trial of Nivolumab and Cetuximab After Chemoradiation in Esophageal Squamous Cell Carcinoma Patients.",
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      "nct": "NCT04278092",
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      "title": "Study to Assess the Efficacy and Safety of Nivolumab in Combination With Paclitaxel in Subjects With Head and Neck Cancer Unable for Cisplatin-based Chemotherapy (NIVOTAX)",
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      "title": "CIML NK Cell in Head & Neck Cancer",
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      "title": "Study of BMS-986315 Alone and in Combination With Nivolumab or Cetuximab in Participants With Advanced Solid Tumors",
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      "title": "Lenvatinib (E7080/MK-7902) in Combination With Pembrolizumab (MK-3475) vs. Standard Chemotherapy and Lenvatinib Monotherapy in Participants With Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma That Progressed After Platinum Therapy and Immunotherapy (MK-7902-009/E7080-G000-228/LEAP-009)",
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      "title": "Safety and Preliminary Efficacy of SNK01 in Combination With Trastuzumab or Cetuximab in Subjects With Advanced HER2 or EGFR Cancers",
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      "title": "Anti-EGFR Therapy With IMRT Concurrent Chemoradiotherapy in Locally Advanced OPC Resistant to Induction Chemotherapy",
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      "title": "Study of NKTR 255 in Combination With Cetuximab in Solid Tumors",
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      "title": "A Study of Toripalimab Injection (JS001) + Cetuximab in Treatment of Advanced Head and Neck Squamous Cell Cancer",
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      "title": "A Prospective Study of Daily Adaptive Radiotherapy to Better Organ-at-Risk Doses in Head and Neck Cancer",
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      "title": "FT538 in Combination With Monoclonal Antibodies in Advanced Solid Tumors",
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      "title": "A Study to Test Whether Different Combinations of BI 765063, Ezabenlimab, Chemotherapy, Cetuximab, and BI 836880 Help People With Head and Neck Cancer or Liver Cancer",
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      "title": "A Phase 1b Study of WU-NK-101 in Combination With Cetuximab",
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      "title": "Pilot Study of Imatinib Cetuximab Combo for H & N Cancer",
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      "title": "Study Comparing RT With Cetuximab + Xevinapant to RT With Cetuximab-placebo in Patients With Head and Neck Cancer",
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      "title": "Phase II Trial of Magrolimab and Cetuximab With Pembrolizumab or Docetaxel for Recurrent/Metastatic Head Neck Squamous Cell Carcinoma",
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      "title": "Toripalimab in Combined With Cetuximab\uff0cChemotherapy for Conversion Therapy of Locally Nonresectable OCSCC",
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      "title": "FID-007 and Cetuximab in Treating Patients With Advanced Head and Neck Squamous Cell Carcinoma",
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      "title": "A Study to Test Whether Treatment With BI 770371 in Combination With Pembrolizumab With or Without Cetuximab Helps People With Head and Neck Cancer Compared With Pembrolizumab Alone",
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      "title": "Durvalumab in Combination With Docetaxel, Cisplatin and 5-FU for Locally Advanced Head and Neck Squamous Cell Carcinoma",
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     {
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      "title": "Durvalumab, Cetuximab and Radiotherapy in Head Neck Cancer",
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      "last_update": "2017-11-22",
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     {
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     {
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      "title": "Durvalumab With or Without Tremelimumab in Treating Participants With Stage II-IVA Oropharyngeal Squamous Cell Cancer",
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      "title": "Carboplatin, Nab-Paclitaxel, Durvalumab Before Surgery and Adjuvant Therapy in Head and Neck Squamous Cell Carcinoma",
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      "title": "A Trial of Durvalumab and Tremelimumab in Combination With SBRT in Patients With Metastatic Cancer",
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      "title": "QUILT-3.055: A Study of Combination Immunotherapies in Patients Who Have Previously Received Treatment With Immune Checkpoint Inhibitors",
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      "nct": "NCT03258554",
      "title": "Radiation Therapy With Durvalumab or Cetuximab in Treating Patients With Locoregionally Advanced Head and Neck Cancer Who Cannot Take Cisplatin",
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     {
      "nct": "NCT03283605",
      "title": "Immunotherapy and SBRT for Metastatic Head and Neck Carcinomas",
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     {
      "nct": "NCT03292250",
      "title": "Korean Cancer Study Group: Translational bIomarker Driven UMbrella Project for Head and Neck (TRIUMPH), Esophageal Squamous Cell Carcinoma- Part 1 (HNSCC)]",
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     {
      "nct": "NCT03377400",
      "title": "Definitive CCRT Combined With Durvalumab and Tremelimumab for Inoperable Esophageal Cancer",
      "status": "UNKNOWN",
      "last_update": "2020-12-17",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT03381183",
      "title": "IRX-2 Regimen and Durvalumab, for Incurable H&N Squamous Cell Carcinoma",
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     {
      "nct": "NCT03410615",
      "title": "Cisplatin + Radiotherapy vs Durvalumab + Radiotherapy Followed by Durvalumab vs Durvalumab + Radiotherapy Followed by Tremelimumab + Durvalumab in Intermediate-Risk HPV-Positive Oropharyngeal SCC",
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     {
      "nct": "NCT03450967",
      "title": "Durvalumab Plus Tremelimumab Combined With Proton Therapy for HNSCC",
      "status": "UNKNOWN",
      "last_update": "2021-08-10",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT03509012",
      "title": "Immunotherapy in Combination With Chemoradiation in Patients With Advanced Solid Tumors",
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      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT03518606",
      "title": "Metronomic Oral Vinorelbine Plus Anti-PD-L1/Anti-CTLA4 ImmunothErapy in Patients With Advanced Solid Tumours",
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      "last_update": "2025-01-15",
      "phase": "PHASE1/PHASE2",
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     {
      "nct": "NCT03522584",
      "title": "Durvalumab, Tremelimumab and Hypofractionated Radiation Therapy in Treating Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma",
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      "last_update": "2023-06-12",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT03529422",
      "title": "Durvalumab With Radiotherapy for Adjuvant Treatment of Intermediate Risk SCCHN",
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      "last_update": "2026-06-23",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT03544723",
      "title": "Safety and Efficacy of p53 Gene Therapy Combined With Immune Checkpoint Inhibitors in Solid Tumors.",
      "status": "UNKNOWN",
      "last_update": "2020-06-09",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03618134",
      "title": "Stereotactic Body Radiation Therapy and Durvalumab With or Without Tremelimumab Before Surgery in Treating Participants With Human Papillomavirus Positive Oropharyngeal Squamous Cell Caner",
      "status": "TERMINATED",
      "last_update": "2023-11-18",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT03618654",
      "title": "Durvalumab With or Without Metformin in Treating Participants With Head and Neck Squamous Cell Carcinoma",
      "status": "COMPLETED",
      "last_update": "2025-05-15",
      "phase": "EARLY_PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT03623646",
      "title": "Cisplatin or ImmunoTHerapy in Association With Definitive Radiotherapy in HPV-related oropharyngEal Squamous Cell Carcinoma: a Randomized Phase II Trial.",
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      "last_update": "2025-08-08",
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      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT03624231",
      "title": "Feasibility & Efficacy of Durvalumab+Tremelimumab+RT and Durvalumab+RT in Non-resect. Locally Advanced HPVnegativ HNSCC",
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      "last_update": "2023-08-31",
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      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT03635164",
      "title": "Radiotherapy With Durvalumab Prior to Surgical Resection for HPV Negative Squamous Cell Carcinoma",
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      "last_update": "2025-06-27",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT03653052",
      "title": "Do Changes in ctDNA Predict Response for Patients With Oesophageal Cancer Receiving Durvalumab",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-04-24",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT03673735",
      "title": "Maintenance Immune Check-point Inhibitor Following Post-operative Chemo-radiation in Subjects With HPV-negative HNSCC",
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      "last_update": "2021-05-10",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT03691714",
      "title": "Durvalumab (MEDI4736) With Cetuximab in Previously Treated Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma",
      "status": "COMPLETED",
      "last_update": "2026-09-02",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT03723967",
      "title": "FRAIL-IMMUNE (GORTEC 2018-03) - Combination of Durvalumab With Carboplatin/Paclitaxel",
      "status": "COMPLETED",
      "last_update": "2024-04-22",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03726775",
      "title": "Trial Evaluating the Tolerance and Safety of Durvalumab - RT Combination for Treatment in SCCHN",
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      "nct": "NCT03737968",
      "title": "Window of Opportunity Trial of Durvalumab (MEDI4736) or Durvalumab/Tremelimumab as Neoadjuvant Chemotherapy to Identify Immune Dynamics in Surgically Resectable Head and Neck Cancer Patients.",
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      "title": "Dose Escalation Study of mRNA-2752 for Intratumoral Injection to Participants in Advanced Malignancies",
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      "nct": "NCT03799744",
      "title": "Safety,Tolerability,and Efficacy of VCN-01 With Durvalumab in R/M Head and Neck Squamous Cell Carcinoma",
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     {
      "nct": "NCT03829007",
      "title": "PD-L1 ImagiNg to prediCt Durvalumab Treatment Response in HNSCC",
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     {
      "nct": "NCT03983954",
      "title": "Naptumomab Estafenatox in Combination With Durvalumab in Subjects With Selected Advanced or Metastatic Solid Tumor, Including a Cohort Expansion in Esophageal Cancer.",
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      "nct": "NCT04001413",
      "title": "Therapy for High-Risk HPV 16-Positive Oropharynx Cancer Patients",
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     {
      "nct": "NCT04054518",
      "title": "Durvalumab as Maintenance Following Chemoradiation for Unresectable Esophageal Squamous Cell Carcinoma",
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      "last_update": "2019-08-13",
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     {
      "nct": "NCT04116047",
      "title": "CompARE: Escalating Treatment of Intermediate and High-risk Oropharyngeal Cancer (OPC)",
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     {
      "nct": "NCT04231864",
      "title": "Durvalumab and Epacadostat for Treatment of Unresectable, Recurrent, or Metastatic Epstein-Barr Virus Positive Nasopharyngeal Cancer",
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     {
      "nct": "NCT04262388",
      "title": "A Multi-Cancer, Multi-State, Platform Study of Durvalumab (MEDI4736) and Oleclumab (MEDI9447) in Pancreatic Adenocarcinoma, Non-Small Cell Lung Cancer and Squamous Cell Carcinoma of the Head and Neck to Correlate Clinical, Molecular and Immunologic Parameters With DNA Methylation",
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     {
      "nct": "NCT04379596",
      "title": "Ph1b/2 Study of the Safety and Efficacy of T-DXd Combinations in Advanced HER2-expressing Gastric Cancer (DESTINY-Gastric03)",
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     {
      "nct": "NCT04447612",
      "title": "Concurrent Chemoradiation and Durvalumab for Locoregionally Advanced Nasopharyngeal Carcinoma",
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      "phase": "PHASE2",
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      "nct": "NCT04504669",
      "title": "First Time in Human Study of AZD8701 With or Without Durvalumab in Participants With Advanced Solid Tumours",
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      "title": "Study of Durvalumab Versus Placebo in Combination With Definitive Chemoradiation Therapy in Patient With ESCC",
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      "title": "Study of Anti-PD-L1 in Combination With Chemo(Radio)Therapy for Resectable Esophageal Squamous Cell Carcinoma",
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     {
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      "title": "Radiotherapy Plus Durvalumab in Elderly Esophageal Squamous Cell Carcinoma",
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     {
      "nct": "NCT05429866",
      "title": "Immunological Variables Associated to ICI Toxicity in Cancer Patients",
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     {
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     {
      "nct": "NCT06446570",
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      "title": "Erlotinib and Docetaxel With Concomitant Boost Radiation Therapy (XRT) for Head and Neck Squamous Cell Carcinoma (HNSCC)",
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      "title": "Study of RADPLAT and Tarceva in Locally Advanced Head and Neck Squamous Cell Carcinoma (SCCA)",
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      "title": "Bevacizumab/Tarceva and Tarceva/Sulindac in Squamous Cell Carcinoma of the Head and Neck",
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      "title": "Erlotinib Hydrochloride and Cetuximab in Treating Patients With Advanced Gastrointestinal Cancer, Head and Neck Cancer, Non-Small Cell Lung Cancer, or Colorectal Cancer",
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     {
      "nct": "NCT00400374",
      "title": "Secondary Primary Tumor Prevention With EGFR, OSI-774, and Cyclooxygenase-2",
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      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00402779",
      "title": "Erlotinib Prevention of Oral Cancer (EPOC)",
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     {
      "nct": "NCT00405405",
      "title": "Phase I of Biologics and Chemoradiation Therapy for Advanced Head and Neck Cancer",
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      "title": "Cisplatin and Radiation Therapy With or Without Erlotinib Hydrochloride in Treating Patients With Stage III or Stage IV Head and Neck Cancer",
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      "last_update": "2013-05-10",
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     {
      "nct": "NCT00412217",
      "title": "A Study of Erlotinib (Tarceva) in Participants With Resected Head and Neck Squamous Cell Cancer",
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      "last_update": "2016-11-25",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00442455",
      "title": "Erlotinib,Radiation and Cisplatin in Patients With Complete Resected Squamous Cell Carcinoma of the Head and Neck",
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      "last_update": "2019-06-06",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00442507",
      "title": "Erlotinib and Avastin in Patients With Cancer of the Esophagus or Gastroesophageal Junction",
      "status": "TERMINATED",
      "last_update": "2015-07-24",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00448240",
      "title": "Erlotinib (Tarceva) During First Line Standard Platinum Containing Chemo for Advanced Squamous Cell Head and Neck Cancer",
      "status": "TERMINATED",
      "last_update": "2025-03-18",
      "phase": "PHASE2/PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00524121",
      "title": "Erlotinib and Radiation Therapy in Treating Older Patients With Stage I, Stage II, Stage III, or Stage IV Esophageal Cancer",
      "status": "COMPLETED",
      "last_update": "2016-04-14",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00539617",
      "title": "Chemotherapy & Erlotinib in Treating Patients w/ Esophageal or Gastroesophageal Cancer That Cannot Be Removed by Surgery",
      "status": "TERMINATED",
      "last_update": "2020-03-23",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00566800",
      "title": "Erlotinib in Treating Patients With Barrett Esophagus",
      "status": "UNKNOWN",
      "last_update": "2013-09-17",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00570232",
      "title": "UAB 0718 - Phase II Trial to Assess Target Oral Therapy as Adjuvant Chemoprevention in High-Risk Head and Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2015-05-21",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00573989",
      "title": "Intensity-Modulated Radiation Therapy, Pemetrexed, and Erlotinib in Treating Patients With Recurrent or Second Primary Head and Neck Cancer",
      "status": "TERMINATED",
      "last_update": "2019-01-03",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00601913",
      "title": "Erlotinib and Surgery in Treating Patients With Head and Neck Cancer That Can Be Removed by Surgery",
      "status": "COMPLETED",
      "last_update": "2018-07-05",
      "phase": "EARLY_PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00603915",
      "title": "A Study of Gemcitabine and Cisplatin/Carboplatin Plus Erlotinib in Patients With Nasopharyngeal Cancer",
      "status": "COMPLETED",
      "last_update": "2019-02-28",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00686114",
      "title": "Concurrent Chemoradiotherapy Containing Paclitaxel&Cisplatin With/Without Tarceva in Locally Advanced Esophageal Cancer",
      "status": "UNKNOWN",
      "last_update": "2014-04-29",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00720304",
      "title": "Erlotinib, Docetaxel, and Radiation Therapy in Stage III or Stage IV Squamous Cell Carcinoma of the Head and Neck",
      "status": "COMPLETED",
      "last_update": "2024-08-22",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00738751",
      "title": "Phase I Study of LBH589 & Erlotinib for Advanced Aerodigestive Tract Cancers",
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     {
      "nct": "NCT00750555",
      "title": "Maintenance of Tarceva (Erlotinib) in Patients With Locally Advanced Head and Neck Cancer",
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     {
      "nct": "NCT00779389",
      "title": "Comparison of Biomarker Modulation by Inhibition of EGFR and/or SRC Family",
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     {
      "nct": "NCT00942734",
      "title": "Trial of RAD001 and Erlotinib With Recurrent Head and Neck Squamous Cell Carcinoma",
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      "title": "Phase Ib Study of Erlotinib Prior to Surgery in Patients With Head and Neck Cancer",
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      "last_update": "2025-09-05",
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     {
      "nct": "NCT00970502",
      "title": "Erlotinib, Celecoxib and Reirradiation for Recurrent Head and Neck Cancer",
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      "last_update": "2017-04-10",
      "phase": "PHASE1/PHASE2",
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     {
      "nct": "NCT01009203",
      "title": "Temsirolimus (Torisel\u00ae) and Erlotinib (Tarceva\u00ae) in Platinum-Refractory/Ineligible, Advanced, Squamous Cell Carcinoma",
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      "last_update": "2015-08-10",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT01064479",
      "title": "Combination Chemotherapy With or Without Erlotinib Hydrochloride in Treating Patients With Metastatic or Recurrent Squamous Cell Carcinoma of the Head and Neck",
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      "last_update": "2024-07-16",
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     {
      "nct": "NCT01116336",
      "title": "Phase I Chemoprevention Trial With Green Tea Polyphenon E & Erlotinib in Patients With Premalignant Lesions of the Head & Neck",
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      "last_update": "2018-12-05",
      "phase": "PHASE1",
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     {
      "nct": "NCT01116622",
      "title": "Erlotinib (Tarceva) and Bexarotene (Targretin) Oral Capsules in Advanced Cancers of the Aerodigestive Tract",
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     {
      "nct": "NCT01192815",
      "title": "Erlotinib Hydrochloride and Radiation Therapy in Stage III-IV Squamous Cell Cancer of the Head and Neck",
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      "nct": "NCT01316757",
      "title": "Carboplatin, Paclitaxel, Cetuximab, and Erlotinib Hydrochloride in Treating Patients With Metastatic or Recurrent Head and Neck Squamous Cell Cancer",
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     {
      "nct": "NCT01332279",
      "title": "Everolimus, Erlotinib Hydrochloride, and Radiation Therapy in Treating Patients With Recurrent Head and Neck Cancer Previously Treated With Radiation Therapy",
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      "nct": "NCT01465815",
      "title": "Phase I/II Study of Postoperative Adjuvant Chemoradiation for Advanced-Stage Cutaneous Squamous Cell Carcinoma of the Head and Neck (cSCCHN)",
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     {
      "nct": "NCT01515137",
      "title": "Study of TARCEVA (Erlotinib) as Adjuvant Treatment for Locally Advanced Head and Neck Squamous Cell Carcinoma",
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     {
      "nct": "NCT01561014",
      "title": "Oxaliplatin, Fluorouracil, Erlotinib Hydrochloride, and Radiation Therapy Before Surgery and Erlotinib Hydrochloride After Surgery in Treating Patients With Locally Advanced Cancer of the Esophagus or Gastroesophageal Junction",
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     {
      "nct": "NCT01927744",
      "title": "Study of Chemotherapy With Cisplatin/Carboplatin, and Docetaxel With or Without Erlotinib in Patients With Head and Neck Squamous Cell Carcinomas Amenable for Surgical Resection",
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     {
      "nct": "NCT02748707",
      "title": "Effect of COX-2 and EGFR Suppression on Molecular Markers of Angiogenesis and Proliferation in Squamous Cell Carcinoma of Oral Cavity - Prospective Randomized Study",
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     {
      "nct": "NCT05827614",
      "title": "Study of the CHK1 Inhibitor BBI-355, an ecDNA-directed Therapy (ecDTx), and the RNR Inhibitor BBI-825, in Subjects With Tumors With Oncogene Amplifications",
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      "last_update": "2026-08-19",
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      "title": "Dose Finding Study Of PF-05212384 With Paclitaxel And Carboplatin In Patients With Advanced Solid Tumor",
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     {
      "nct": "NCT03065062",
      "title": "Study of the CDK4/6 Inhibitor Palbociclib (PD-0332991) in Combination With the PI3K/mTOR Inhibitor Gedatolisib (PF-05212384) for Patients With Advanced Squamous Cell Lung, Pancreatic, Head & Neck and Other Solid Tumors",
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     {
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      "title": "Gefitinib in Treating Patients With Metastatic or Unresectable Head and Neck Cancer or Non-Small Cell Lung Cancer",
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      "nct": "NCT00083057",
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     {
      "nct": "NCT00088907",
      "title": "Phase III Trial Of Docetaxel Versus Docetaxel Plus ZD1839 In Head And Neck Cancer",
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     {
      "nct": "NCT00093652",
      "title": "Oxaliplatin, Gefitinib, and Radiation Therapy in Treating Patients With Locally Advanced or Metastatic Esophageal Cancer",
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     {
      "nct": "NCT00095836",
      "title": "Gefitinib in Treating Patients With Locally Advanced or Metastatic Thyroid Cancer That Did Not Respond to Iodine Therapy",
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      "title": "Post-operative Radiotherapy With Cisplatin Alone or in Combination With Iressa in Upper Aerodigestive Tract Carcinomas",
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     {
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      "phase": "PHASE3",
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     {
      "nct": "NCT00212108",
      "title": "A Study Of Nasopharyngeal Carcinoma (NPC) Treated With Celecoxib And ZD1839",
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      "title": "Cisplatin and Irinotecan Chemotherapy, Followed by ZD 1839 (Iressa) in Patients With Esophageal or Gastric Carcinomas",
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      "title": "Effect of Iressa With/Without Concurrent Chemoradiotherapy on Tumor Gene Expression Profiles in Patients With Advanced Non-Nasopharyngeal Head and Neck Carcinoma",
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      "title": "IRESSA\u2122 (Gefitinib) With Cisplatin Plus Radiotherapy for the Treatment of Previously Untreated Unresected Late Stage III/IV Non-Metastatic Head and Neck Squamous Cell Carcinoma",
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     {
      "nct": "NCT00233636",
      "title": "Iressa and Radiotherapy in the Treatment of the Locally Advanced Inoperable Squamous Cell Carcinoma of the Head and Neck",
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     {
      "nct": "NCT00239304",
      "title": "Gefitinib (Iressa) in Combo With Chemoradiation in Patients With Locally Advanced Head & Neck Cancer",
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      "nct": "NCT00242749",
      "title": "IRESSA in Combination With Cisplatin & Radiotherapy in Patients With Advanced Head & Neck Carcinoma",
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      "title": "ZD1839 (IRESSA\u2122) in Combination With Docetaxel & Cisplatin in Subjects With Metastatic Head & Neck Cancer",
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      "title": "Gefitinib in Treating Patients With Stage I, Stage II, or Stage III Esophageal Cancer That Can Be Removed By Surgery",
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      "phase": "PHASE2",
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     {
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      "title": "Radiotherapy,Chemotherapy,Before and After Surgery in Advanced Esophageal or Gastroesophageal Junction Cancer",
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      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00268346",
      "title": "Gefitinib in Treating Patients With Recurrent or Metastatic Esophageal or Gastroesophageal Junction Cancer",
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      "phase": "PHASE2",
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     {
      "nct": "NCT00290719",
      "title": "Gefitinib, Cisplatin, Irinotecan, and Radiation Therapy Before Surgery in Treating Patients With Esophageal Cancer or Gastroesophageal Junction Cancer That Can Be Removed By Surgery",
      "status": "TERMINATED",
      "last_update": "2014-05-09",
      "phase": "PHASE1",
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     {
      "nct": "NCT00352105",
      "title": "Cisplatin, Fluorouracil, Iressa, and Radiation Therapy Patients With Locally Advanced Head and Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2012-11-05",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00493025",
      "title": "Paclitaxel, Cisplatin, Gefitinib, and Radiation Therapy Followed by Surgery and Gefitinib in Treating Patients With Locally Advanced Cancer of the Esophagus or Gastroesophageal Junction That Can Be Removed By Surgery",
      "status": "TERMINATED",
      "last_update": "2018-12-06",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00509002",
      "title": "Iressa Study in Patients With Salivary Gland Cancer",
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      "last_update": "2017-11-24",
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      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00519077",
      "title": "Phase II Study of Skin Toxicity Dosing of IRESSA (Gefitinib) in Squamous Cell Carcinoma of the Head and Neck",
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      "last_update": "2016-07-01",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00681967",
      "title": "Postoperative Radiotherapy Plus Iressa or Radiotherapy Plus Cisplatin and Iressa for Advanced Head & Neck Cancer",
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     {
      "nct": "NCT00820417",
      "title": "Pharmocokinetic/Pharmacodynamic (PK/PD) Study of the Combination Cetuximab/Gefitinib",
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      "phase": "PHASE1",
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     {
      "nct": "NCT01185158",
      "title": "A Phase II Study of 250-mg ZD1839 Monotherapy in Recurrent or Metastatic or Both Recurrent and Metastatic Squamous Cell Carcinoma",
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      "last_update": "2023-11-29",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT01185171",
      "title": "Trial of Induction Chemotherapy With Carboplatin and Paclitaxel, Followed by Concurrent Chemotherapy/Radiation Therapy With ZD1839 (IRESSA), 5-FU, Hydroxyurea, and Twice-Daily Radiation, Followed by Adjuvant ZD1839 Monotherapy in Patients With Locally Advanced Head & Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2023-05-11",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01243398",
      "title": "Gefitinib in Treating Patients With Esophageal Cancer That is Progressing After Chemotherapy",
      "status": "COMPLETED",
      "last_update": "2012-11-29",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01291823",
      "title": "Gefitinib Combined With Radiotherapy in Elderly Patients With Esophageal Cancer",
      "status": "UNKNOWN",
      "last_update": "2011-02-08",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01405846",
      "title": "Feasibility Study to Estimate Number of Patients With Precancerous Areas in Their Airways and the Response to Gefitinib",
      "status": "TERMINATED",
      "last_update": "2016-08-19",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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    ]
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    "trials": [
     {
      "nct": "NCT01534585",
      "title": "Safety and Efficacy Study of Icotinib With Intensity-modulated Radiotherapy in Nasopharyngeal Carcinoma",
      "status": "COMPLETED",
      "last_update": "2018-04-17",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01855854",
      "title": "Second-line Treatment With Icotinib in Esophageal Carcinoma Patients With EGFR Overexpression (IHC 3+) or Positive FISH",
      "status": "COMPLETED",
      "last_update": "2019-07-05",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01973725",
      "title": "Study of Icotinib Hydrochloride in Treating Patients With Recurrent or Metastatic Esophageal Cancer After Failure of Conventional Chemotherapy",
      "status": "COMPLETED",
      "last_update": "2023-02-17",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT02328261",
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      "title": "Nimotuzumab Combined With Toripalimab and Chemotherapy for Locally Advanced Tonsillar Cancer",
      "status": "RECRUITING",
      "last_update": "2026-01-20",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07445048",
      "title": "Postoperative Radiotherapy Combined With Nimotuzumab Followed by Benmelstobart in High-Risk Patients With Head and Neck Squamous Cell Carcinoma",
      "status": "RECRUITING",
      "last_update": "2026-04-17",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07457528",
      "title": "Efficacy and Safety of Neo-CRT Plus Serplulimab, Nimotuzumab in Patients With Locally Advanced Resectable ESCC",
      "status": "RECRUITING",
      "last_update": "2026-03-11",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT07601737",
      "title": "Nimotuzumab Combined With Immunotherapy and Chemotherapy in the Treatment of Locally Advanced Head and Neck Squamous Cell Carcinoma",
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      "last_update": "2026-07-09",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT07706985",
      "title": "Efficacy and Safety of TPC Induction Chemotherapy Combined With Nimotuzumab and Toripalimab \"Immune Sandwich\" Regimen Versus Full-Course Immunotherapy for Locally Advanced Nasopharyngeal Carcinoma",
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      "last_update": "2026-07-16",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00702481",
      "title": "Study of Nimotuzumab and Cisplatin/Radiotherapy for Locally Advanced Head and Neck Squamous Cell Cancer",
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      "last_update": "2023-02-28",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00910117",
      "title": "Induction Chemotherapy With Nimotuzumab in Locally Advanced Head and Neck Squamous Cell Carcinoma (HNSCC)",
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      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00957086",
      "title": "Study of Post-Op Adjuvant Concurrent Chemo-RT With or Without Nimotuzumab for Head & Neck Cancer",
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      "last_update": "2024-01-09",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT01074021",
      "title": "Nimotuzumab in Combination With Chemoradiation for Nasopharyngeal Cancer",
      "status": "UNKNOWN",
      "last_update": "2015-10-30",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT01249352",
      "title": "A Study of Chemoradiation Associated with Nimotuzumab As the Treatment of Locally Advanced Esophageal Cancer",
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      "last_update": "2025-03-31",
      "phase": "PHASE2/PHASE3",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT01336049",
      "title": "Nimotuzumab Plus Paclitaxel and Cisplatin as 1st Line Treatment for Esophageal Squamous Cell Cancer",
      "status": "UNKNOWN",
      "last_update": "2011-04-15",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT01345084",
      "title": "Study Comparing Radiation Therapy and Chemotherapy With or Without Nimotuzumab",
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      "last_update": "2025-03-28",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT01402180",
      "title": "Chemoradiation With or Without Nimotuzumab in Treating Esophageal Cancer Patients Who Suffer With Recurrence in Regional Lymph Nodes After Esophagectomy",
      "status": "UNKNOWN",
      "last_update": "2011-07-26",
      "phase": "PHASE2/PHASE3",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT01425736",
      "title": "Nimotuzumab in Combination With TPF(Cisplatin ,Fluorouracil and Docetaxel) for Head and Neck Squamous Cell Carcinoma",
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      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT01463605",
      "title": "Nimotuzumab Combined With Radiotherapy for Older Patients With Esophageal Cancer: a Single, Non-control Clinical Trial",
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      "last_update": "2021-02-04",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT01516996",
      "title": "Safety and Efficacy Study of Nimotuzumab Plus Neoadjuvant and Concurrent Chemoradiotherapy to Treat Oropharynx and Hypopharynx Cancer",
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      "last_update": "2012-03-20",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT01616849",
      "title": "Study of Chemotherapy Combined With Nimotuzumab in Untreated Metastatic Nasopharyngeal Carcinoma",
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      "last_update": "2015-09-22",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT01688700",
      "title": "Study of Nimotuzumab in Combination With Neoadjuvant Chemotherapy for Resectable Esophageal Squamous Cell Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2012-09-20",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT01993784",
      "title": "Study of Nimotuzumab to Treat Esophageal Squamous Cell Carcinoma.",
      "status": "UNKNOWN",
      "last_update": "2013-11-25",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT02011594",
      "title": "Phase II Study of Maintenance Treatment of Nimotuzumab for Advanced Esophageal Carcinoma",
      "status": "WITHDRAWN",
      "last_update": "2015-02-12",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT02012062",
      "title": "Concurrent Nimotuzumab Versus Cisplatin With Radiotherapy for Locoregionally Advanced NPC",
      "status": "COMPLETED",
      "last_update": "2019-04-10",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02034968",
      "title": "Nimotuzumab Plus Nab-paclitaxel and Cisplatin in Treating Patients With Advanced Esophageal Carcinoma",
      "status": "WITHDRAWN",
      "last_update": "2015-03-05",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT02041819",
      "title": "Neoadjuvant Chemotherapy of Nimotuzumab Plus Nab-Paclitaxel in Squamous Cell Carcinoma of Esophagus",
      "status": "WITHDRAWN",
      "last_update": "2015-03-05",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT02272699",
      "title": "Neoadjuvant Treatment of Nimotuzumab With Chemotherapy or Radiotherapy in Resectable Esophageal Squamous Cell Carcinoma",
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      "phase": "PHASE2/PHASE3",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT02293356",
      "title": "Phase IV Clinical Trial of Nimotuzumab in the Treatment of Nasopharyngeal Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2015-08-19",
      "phase": "PHASE4",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT02858206",
      "title": "Simultaneous Integrated Boost Radiotherapy and Concurrent Nimotuzumab or Chemotherapy for Esophageal Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2019-07-26",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03025958",
      "title": "Radiation Plus Concurrent Nimotuzumab in Elderly Patients With Locoregionally Advanced Nasopharyngeal Carcinoma",
      "status": "COMPLETED",
      "last_update": "2024-05-06",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT03200691",
      "title": "Neoadjuvant Anti-PD-1 Antibody SHR-1210 and Radiation in Resectable Esophageal Squamous Cell Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2017-08-07",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03557112",
      "title": "By Comparing TPF Induction Chemotherapy Combined With Nimotuzumab Concurrent Radiotherapy and Cisplatin Concurrent Radio-chemotherapy for Locally Advanced NPC",
      "status": "UNKNOWN",
      "last_update": "2018-11-02",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03666221",
      "title": "Nimotuzumab for Recurrent Nasopharyngeal Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2018-09-11",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03708822",
      "title": "Study of Docetaxel and Cisplatin Combined With Nimotuzumab As First-Line Treatment in Patients With Recurrent or Metastatic Nasopharyngeal Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2024-01-18",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03766178",
      "title": "Study of Anti-PD-1 Antibody SHR-1210 Plus Nimotuzumab in the Treatment of Advanced Esophageal Squamous Cell Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2021-07-07",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03837808",
      "title": "Radiotherapy Plus Concurrent Nimotuzumab or Cisplatin in Stage II-III Nasopharyngeal Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2022-11-07",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT03915132",
      "title": "Nimotuzumab Combined With VMAT in Elderly Patients With Nasopharyngeal Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2021-01-29",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT04207918",
      "title": "A Phase II Study of Chemoradiotherapy With Nimotuzumab in Unresectable Esophageal Cancer",
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      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT04223024",
      "title": "Concurrent Chemoradiotherapy With Nimotuzumab for High Risk Nasopharyngeal Carcinoma",
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      "phase": "PHASE2",
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     {
      "nct": "NCT04367909",
      "title": "A Study of TC(Docetaxel and Carboplatin) Regimen With or Without Nimotuzumab in Recurrent Metastatic Oral Squamous Cell Carcinoma",
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      "last_update": "2021-11-08",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT04456322",
      "title": "Radiotherapy Plus Nimotuzumab or Cisplatin in Nasopharyngeal Carcinoma",
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      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT04508816",
      "title": "Anti-EGFR Therapy Plus IMRT Concurrent Chemoradiotherapy in Locally Advanced NPC Resistant to Induction Chemotherapy",
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      "phase": "PHASE2",
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     {
      "nct": "NCT04508829",
      "title": "Anti-EGFR Therapy With IMRT Concurrent Chemoradiotherapy in Locally Advanced OPC Resistant to Induction Chemotherapy",
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      "phase": "PHASE2",
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     {
      "nct": "NCT04882462",
      "title": "Sintilimab and Nimotuzumab Combined With Chemotherapy for the Treatment of R/M HNSCC.",
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      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT05024019",
      "title": "Nimotuzumab Combined With Radiotherapy in High-risk Patients With HNSCC Not Suitable for Cisplatin After Surgery",
      "status": "UNKNOWN",
      "last_update": "2021-08-27",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT05351762",
      "title": "Nimotuzumab Combined With Neoadjuvant Chemotherapy in the Treatment of Resectable LA HNSCC",
      "status": "UNKNOWN",
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      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT05355168",
      "title": "Neoadjuvant CRT Combined With Camrelizumab and Nimotuzumab for Initially Inoperable Patients With Esophageal Carcinoma",
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     {
      "nct": "NCT05803915",
      "title": "Neoadjuvant Toripalimab Plus Nimotuzumab in Oral Squamous Cell Carcinoma Prior to Radical Therapy",
      "status": "UNKNOWN",
      "last_update": "2023-04-07",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06022276",
      "title": "Nimotuzumab for EGFR-amplified Advanced Pan Solid Tumors",
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      "last_update": "2023-09-01",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
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      "nct": "NCT06048913",
      "title": "Nimotuzumab Combined With Concurrent Chemoradiotherapy for Locally Advanced Treatment Esophageal Cancer in Old Age",
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     {
      "nct": "NCT06259721",
      "title": "Anti-PD1 Monoclonal Antibody Combined With Nimotuzumab and Capecitabine in Patients With First-line Platinum-resistant Recurrent/Metastatic Nasopharyngeal Carcinoma",
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     {
      "nct": "NCT06879691",
      "title": "A Trial of Nimotuzumab and Pinkiller Efficacy and Pain in Advanced Head and Neck Squamous Cell Carcinoma",
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     {
      "nct": "NCT07312578",
      "title": "Nimotuzumab,Camrelizumab, and Neoadjuvant Chemotherapy\uff08nCT\uff09 in the Treatment of Esophageal Squamous Cell Carcinoma",
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     {
      "nct": "NCT07354984",
      "title": "A Single-Arm Phase II Clinical Study of Docetaxel Combined With Nimotuzumab and Pucotenlimab as Second-Line and Beyond Therapy for Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma",
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     {
      "nct": "NCT07535567",
      "title": "Postoperative Radiotherapy With Nimotuzumab \u00b1 Benmelstobart in Intermediate-Risk Head and Neck Squamous Cell Carcinoma",
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      "title": "BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study",
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      "title": "CA-4948 in Combination With FOLFOX/PD-1 Inhibitor +/- Trastuzumab for Untreated Unresectable Gastric and Esophageal Cancer",
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      "nct": "NCT05267626",
      "title": "Study of AU-007, A Monoclonal Antibody That Binds to IL-2 and Inhibits IL-2R\u03b1 Binding, in Patients With Unresectable Locally Advanced or Metastatic Cancer",
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      "title": "5-Azacytidine and/or Nivolumab in Resectable HPV-Associated HNSCC",
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      "title": "Study of RiMO-301 and Radiotherapy With PD-1 Inhibitor for the Treatment of Head-Neck Cancer",
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      "title": "Nivolumab in Children and Adults With Nasopharyngeal Carcinoma",
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      "nct": "NCT06022861",
      "title": "A Study to Compare the Efficacy and Safety of LY01015 and Opdivo\u00ae Combined Respectively With Chemotherapy in Advanced or Metastatic Esophageal Squamous Cell Carcinoma",
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      "nct": "NCT06029270",
      "title": "Testing the Addition of BMS-986016 (Relatlimab) to the Usual Immunotherapy After Initial Treatment for Recurrent or Metastatic Nasopharyngeal Cancer",
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      "nct": "NCT06047379",
      "title": "Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis",
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      "nct": "NCT06064097",
      "title": "A Study Using Nivolumab, in Combination With Chemotherapy Drugs to Treat Nasopharyngeal Carcinoma (NPC)",
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      "last_update": "2026-09-11",
      "phase": "PHASE2",
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     {
      "nct": "NCT06084897",
      "title": "Radiotherapy in Patients With Metastatic Esophageal Cancer Responding to PD-1 Inhibitor Plus Chemotherapy",
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      "last_update": "2024-06-14",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06170710",
      "title": "Postoperative CCRT Followed by Immunotherapy in High-Risk LA HNSCC",
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      "last_update": "2023-12-14",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06265285",
      "title": "Comparison of In-Home Versus In-Clinic Administration of Subcutaneous Nivolumab Through Cancer CARE (Connected Access and Remote Expertise) Beyond Walls (CCBW) Program",
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      "last_update": "2026-06-09",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06422403",
      "title": "A Value-Driven Study on Reducing Immune Checkpoint Inhibitor Dosing Frequency in Advanced Cancers",
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      "nct": "NCT06638931",
      "title": "Agnostic Therapy in Rare Solid Tumors",
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     {
      "nct": "NCT06823479",
      "title": "Towards Cure Via Only Ultra-short ICB in CSCC",
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      "nct": "NCT07000253",
      "title": "Timing of Comprehensive Local Treatment After First-Line Systemic Therapy in Oligometastatic Esophageal or Gastric Adenocarcinoma",
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     {
      "nct": "NCT07152678",
      "title": "Brachytherapy With Radiotherapy and Immunotherapy: Guided HDR Trial in Esophageal Squamous Cell Carcinoma",
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      "nct": "NCT07223424",
      "title": "Patient Preference for Subcutaneous vs. Intravenous Immune Therapy",
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     {
      "nct": "NCT07431281",
      "title": "Sonesitatug Vedotin in Combination With Capecitabine With or Without Rilvegostomig in Participants With Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma Expressing Claudin18.2",
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     {
      "nct": "NCT07460765",
      "title": "Safety and Feasibility of Nivolumab-IRDye800CW in Patients With Head and Neck Squamous Cell Carcinoma (HNSCC)",
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     {
      "nct": "NCT01818323",
      "title": "Phase I Trial: T4 Immunotherapy of Head and Neck Cancer",
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     {
      "nct": "NCT02105636",
      "title": "Trial of Nivolumab vs Therapy of Investigator's Choice in Recurrent or Metastatic Head and Neck Carcinoma (CheckMate 141)",
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     {
      "nct": "NCT02124850",
      "title": "A Phase Ib Study of Neoadjuvant of Cetuximab Plus Motolimod and Cetuximab Plus Motolimod Plus Nivolumab",
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     {
      "nct": "NCT02335918",
      "title": "A Dose Escalation and Cohort Expansion Study of Anti-CD27 (Varlilumab) and Anti-PD-1 (Nivolumab) in Advanced Refractory Solid Tumors",
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      "last_update": "2019-12-09",
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     {
      "nct": "NCT02423863",
      "title": "In Situ, Autologous Therapeutic Vaccination Against Solid Cancers With Intratumoral Hiltonol\u00ae",
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      "last_update": "2020-12-17",
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     {
      "nct": "NCT02465060",
      "title": "Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)",
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      "last_update": "2026-08-28",
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     {
      "nct": "NCT02526017",
      "title": "Study of Cabiralizumab in Combination With Nivolumab in Patients With Selected Advanced Cancers",
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     {
      "nct": "NCT02569242",
      "title": "Study of Nivolumab in Unresectable Advanced or Recurrent Esophageal Cancer",
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     {
      "nct": "NCT02636036",
      "title": "Phase I Study of Enadenotucirev and PD-1 Inhibitor in Subjects With Metastatic or Advanced Epithelial Tumors",
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     {
      "nct": "NCT02637531",
      "title": "A Dose-Escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of IPI-549",
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     {
      "nct": "NCT02684253",
      "title": "Screening Trial of Nivolumab With Image Guided, Stereotactic Body Radiotherapy (SBRT) Versus Nivolumab Alone in Patients With Metastatic Head and Neck Squamous Cell Carcinoma (HNSCC)",
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     {
      "nct": "NCT02741570",
      "title": "Study of Nivolumab in Combination With Ipilimumab Compared to the Standard of Care (Extreme Regimen) as First Line Treatment in Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck",
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     {
      "nct": "NCT02764593",
      "title": "Safety Testing of Adding Nivolumab to Chemotherapy in Patients With Intermediate and High-Risk Local-Regionally Advanced Head and Neck Cancer",
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      "last_update": "2022-11-29",
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      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT02823574",
      "title": "Study of Nivolumab in Combination With Ipilimumab Versus Nivolumab in Combination With Ipilimumab Placebo in Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck",
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     {
      "nct": "NCT02829931",
      "title": "Hypofractionated Stereotactic Irradiation With Nivolumab, Ipilimumab and Bevacizumab in Patients With Recurrent High Grade Gliomas",
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      "last_update": "2023-01-19",
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      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT02834013",
      "title": "Nivolumab and Ipilimumab in Treating Patients With Rare Tumors",
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      "last_update": "2026-06-17",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT02834247",
      "title": "A Study of TAK-659 in Combination With Nivolumab in Participants With Advanced Solid Tumors",
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     {
      "nct": "NCT02842125",
      "title": "Safety and Efficacy of Intra-Arterial and Intra-Tumoral Ad-p53 With Capecitabine (Xeloda) or Anti-PD-1 in Liver Metastases of Solid Tumors and Recurrent Head and Neck Squamous Cell Cancer",
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     {
      "nct": "NCT02946671",
      "title": "Study of Pre-operative Combination Therapy With Mogamulizumab and Nivolumab Against Solid Cancer Patients",
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     {
      "nct": "NCT02955290",
      "title": "CIMAvax Vaccine, Nivolumab, and Pembrolizumab in Treating Patients With Advanced Non-small Cell Lung Cancer or Squamous Head and Neck Cancer",
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      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT03003637",
      "title": "ImmunoModulation by the Combination of Ipilimumab and Nivolumab Neoadjuvant to Surgery In Advanced or Recurrent Head and Neck Carcinoma",
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      "last_update": "2023-10-23",
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      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT03012581",
      "title": "Secured Access to Nivolumab for Adult Patients With Selected Rare Cancer Types",
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      "last_update": "2024-02-28",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT03021993",
      "title": "Trial of Nivolumab as a Novel Neoadjuvant Pre-Surgical Therapy for Locally Advanced Oral Cavity Cancer",
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     {
      "nct": "NCT03044613",
      "title": "Nivolumab +/- Relatlimab Prior to Chemoradiation With II/III Gastro/Esophageal Cancer",
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      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT03097939",
      "title": "Phase 2 Trial of Ipilimumab and Nivolumab in Nasopharyngeal Carcinoma",
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      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT03107182",
      "title": "Chemotherapy and Locoregional Therapy Trial (Surgery or Radiation) for Patients With Head and Neck Cancer",
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     {
      "nct": "NCT03126110",
      "title": "Phase 1/2 Study Exploring the Safety, Tolerability, and Efficacy of INCAGN01876 Combined With Immune Therapies in Advanced or Metastatic Malignancies",
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      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT03129061",
      "title": "Study to Evaluate Immunological Response to PD-1 Inhibition in Squamous Cell Carcinoma of the Head and Neck (SCCHN)",
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      "last_update": "2022-12-05",
      "phase": "PHASE1",
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     {
      "nct": "NCT03132038",
      "title": "Nivolumab in Recurrent or Metastatic Salivary Gland Carcinoma of the Head and Neck",
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      "last_update": "2022-01-11",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT03162731",
      "title": "Nivolumab, Ipilimumab, and Radiation Therapy in Treating Patients With Stage III-IVB Head and Neck Cancer",
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      "phase": "EARLY_PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT03229278",
      "title": "Trigriluzole With Nivolumab and Pembrolizumab in Treating Patients With Metastatic or Unresectable Solid Malignancies or Lymphoma",
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      "last_update": "2023-12-06",
      "phase": "PHASE1",
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     {
      "nct": "NCT03241173",
      "title": "A Study Exploring the Safety and Efficacy of INCAGN01949 in Combination With Immune Therapies in Advanced or Metastatic Malignancies",
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      "last_update": "2022-09-27",
      "phase": "PHASE1/PHASE2",
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     {
      "nct": "NCT03246958",
      "title": "Nivolumab Plus Ipilimumab in Thyroid Cancer",
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      "last_update": "2025-06-19",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT03247712",
      "title": "Neoadjuvant Immunoradiotherapy in Head & Neck Cancer",
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      "last_update": "2026-07-23",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT03267498",
      "title": "Nivolumab + Chemoradiation in Stage II-IVB Nasopharyngeal Carcinoma (NPC)",
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      "last_update": "2026-01-12",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03278626",
      "title": "Immune Checkpoint Therapy With Nivolumab Esophageal Squamous Cell Carcinoma",
      "status": "TERMINATED",
      "last_update": "2022-03-28",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT03313804",
      "title": "Priming Immunotherapy in Advanced Disease With Radiation",
      "status": "COMPLETED",
      "last_update": "2026-03-11",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03317327",
      "title": "REirradiation and Programmed Cell Death Protein 1 (PD-1) Blockade On Recurrent Squamous Cell Head and Neck Tumors",
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      "last_update": "2025-06-03",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT03342352",
      "title": "Nivolumab Plus Epacadostat in Combination With Chemotherapy Versus the EXTREME Regimen in Squamous Cell Carcinoma of the Head and Neck (CheckMate 9NA/ECHO-310)",
      "status": "WITHDRAWN",
      "last_update": "2019-12-20",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03342911",
      "title": "Nivolumab, Carboplatin, and Paclitaxel in Treating Patients With Stage III-IV Head and Neck Squamous Cell Carcinoma That Can Be Removed by Surgery",
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      "last_update": "2025-04-24",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03347123",
      "title": "A Study of Epacadostat and Nivolumab in Combination With Immune Therapies in Participants With Advanced or Metastatic Malignancies (ECHO-208)",
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      "last_update": "2022-02-28",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT03347838",
      "title": "Nivolumab for the Reversal of Squamous Dysplasia in High Risk Current and Former Smokers",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-12-12",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03349710",
      "title": "Nivolumab or Nivolumab Plus Cisplatin, in Combination With Radiotherapy in Patients With Cisplatin-ineligible or Eligible Locally Advanced Squamous Cell Head and Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2021-08-09",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03355560",
      "title": "Adjuvant Nivolumab After Salvage Resection in Head and Neck Cancer Patients Previously Treated With Definitive Therapy",
      "status": "COMPLETED",
      "last_update": "2026-05-06",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT03370276",
      "title": "Cetuximab & Nivolumab in Patients With Recurrent/Metastatic Head & Neck Squamous Cell Carcinoma",
      "status": "COMPLETED",
      "last_update": "2026-04-02",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03386838",
      "title": "An Immuno-therapy Study of Nivolumab in Combination With Experimental Medication BMS-986205 Compared to Standard of Care EXTREME Regimen in First-line Recurrent/Metastatic Squamous Cell Carcinoma of Head and Neck",
      "status": "WITHDRAWN",
      "last_update": "2019-04-18",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03390738",
      "title": "Nivolumab as Treatment for Recurrent/Metastatic Nasopharyngeal Carcinoma After Failing 2 Lines or More Previous Chemotherapy",
      "status": "WITHDRAWN",
      "last_update": "2021-05-03",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03402737",
      "title": "SBRT + Immunomodulating Systemic Therapy for Inoperable, Recurrent H&N",
      "status": "TERMINATED",
      "last_update": "2021-02-18",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03409848",
      "title": "Ipilimumab or FOLFOX in Combination With Nivolumab and Trastuzumab in HER2 Positive EsophagoGastric Adenocarcinoma",
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      "last_update": "2022-05-18",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03416244",
      "title": "A Multicenter Open-label Phase II Trial to Evaluate Nivolumab and Ipilimumab for 2nd Line Therapy in Elderly Patients With Advanced Esophageal Squamous Cell Cancer",
      "status": "COMPLETED",
      "last_update": "2022-09-29",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03435640",
      "title": "REVEAL Study of NKTR-262 in Combination With NKTR-214 and Nivolumab in Patients With Locally Advanced / Metastatic Solid Tumor Malignancies",
      "status": "TERMINATED",
      "last_update": "2023-03-08",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03511391",
      "title": "CHEckpoint Inhibition in Combination With an Immunoboost of External Beam Radiotherapy in Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2024-01-23",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03521570",
      "title": "Intensity-Modulated Radiation Therapy & Nivolumab for Recurrent or Second Primary Head & Neck Squamous Cell Cancer",
      "status": "COMPLETED",
      "last_update": "2024-09-19",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03544723",
      "title": "Safety and Efficacy of p53 Gene Therapy Combined With Immune Checkpoint Inhibitors in Solid Tumors.",
      "status": "UNKNOWN",
      "last_update": "2020-06-09",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03544736",
      "title": "Safety and Feasibility of Irradiation and Nivolumab in Esophageal Cancer (INEC)",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2023-03-22",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03565445",
      "title": "A Study of ASP1948, Targeting an Immune Modulatory Receptor as a Single Agent and in Combination With a PD-l Inhibitor (Nivolumab or Pembrolizumab) in Subjects With Advanced Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2024-11-01",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03575234",
      "title": "Nivolumab & IRX-2 With Surgery for Resectable Stage III-IVA Oral Cavity Cancer or HPV-Positive Oropharyngeal Cancer",
      "status": "WITHDRAWN",
      "last_update": "2019-08-28",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03575598",
      "title": "Sitravatinib (MGCD516) and Nivolumab in Oral Cavity Cancer Window Opportunity Study",
      "status": "COMPLETED",
      "last_update": "2023-07-27",
      "phase": "EARLY_PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03576417",
      "title": "A Trial Evaluating the Addition of Nivolumab to Cisplatin-RT for Treatment of Cancers of the Head and Neck",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-05-07",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03620123",
      "title": "A Randomized Phase II Study on the Optimization of Immunotherapy in Squamous Carcinoma of the Head and Neck",
      "status": "COMPLETED",
      "last_update": "2022-11-18",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03633110",
      "title": "Safety, Tolerability, Immunogenicity, and Antitumor Activity of GEN-009 Adjuvanted Vaccine",
      "status": "COMPLETED",
      "last_update": "2022-04-19",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03645928",
      "title": "Study of Autologous Tumor Infiltrating Lymphocytes in Patients With Solid Tumors",
      "status": "TERMINATED",
      "last_update": "2026-05-15",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03646461",
      "title": "Trial of Ibrutinib Combined With Nivolumab or Cetuximab to Treat Recurrent/Metastatic HNSCC",
      "status": "TERMINATED",
      "last_update": "2026-05-22",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03652233",
      "title": "Afatinib and Nivolumab as Treatment for Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck",
      "status": "WITHDRAWN",
      "last_update": "2019-06-20",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03655444",
      "title": "Abemaciclib + Nivolumab in Patients With Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma That Progressed or Recurred Within Six Months After Platinum-based Chemotherapy",
      "status": "TERMINATED",
      "last_update": "2020-12-03",
      "phase": "PHASE1/PHASE2",
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     {
      "nct": "NCT03690986",
      "title": "VX15/2503 in Combination With Ipilimumab or Nivolumab in Patients With Head and Neck Cancer",
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      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT03692325",
      "title": "Safety and Efficacy of Nivolumab in Treating Oral Proliferative Verrucous Leukoplakia",
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      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT03693014",
      "title": "A Study of Several Radiation Doses for Patients With Progression on Immunotherapy/Checkpoint Inhibitors",
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      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT03715946",
      "title": "Adjuvant De-Escalated Radiation + Adjuvant Nivolumab for Intermediate-High Risk P16+ Oropharynx Cancer",
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     {
      "nct": "NCT03721757",
      "title": "CA209-891: Neoadjuvant and Adjuvant Nivolumab as Immune Checkpoint Inhibition in Oral Cavity Cancer",
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      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT03727061",
      "title": "Porfimer Sodium Interstitial Photodynamic Therapy With or Without Standard of Care Chemotherapy in Treating Patients With Locally Advanced or Recurrent Head and Neck Cancer",
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      "phase": "PHASE1",
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     {
      "nct": "NCT03735628",
      "title": "An Study to Evaluate the Safety and Efficacy of Copanlisib in Combination With Nivolumab in Patients With Advanced Solid Tumors",
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      "last_update": "2023-10-06",
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     {
      "nct": "NCT03749460",
      "title": "Nivolumab and Ipilimumab and Stereotactic Body Radiation Therapy in Treating Patients With Salivary Gland Cancers",
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     {
      "nct": "NCT03758729",
      "title": "Phase II Study of Nivolumab in Combination With Radiation Therapy as Definitive Treatment for Patients With Locally Advanced, Unresectable Head and Neck Mucosal Melanoma.",
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     {
      "nct": "NCT03758781",
      "title": "IRX-2 Regimen Combined With Nivolumab in Recurrent/Metastatic Solid Tumors",
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     {
      "nct": "NCT03764553",
      "title": "Liposomal iRInotecan, Carboplatin or oXaliplatin for Esophagogastric Cancer",
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      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT03799445",
      "title": "Ipilimumab, Nivolumab, and Radiation Therapy in Treating Patients With HPV Positive Advanced Oropharyngeal Squamous Cell Carcinoma",
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      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT03811015",
      "title": "Testing Immunotherapy Versus Observation in Patients With HPV Throat Cancer",
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      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT03829436",
      "title": "TPST-1120 as Monotherapy and in Combination With Nivolumab in Subjects With Advanced Cancers",
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     {
      "nct": "NCT03829722",
      "title": "Radiotherapy, Carboplatin/Paclitaxel and Nivolumab for High Risk HPV-related Head and Neck Cancer",
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      "phase": "PHASE2",
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     {
      "nct": "NCT03841110",
      "title": "FT500 as Monotherapy and in Combination With Immune Checkpoint Inhibitors in Subjects With Advanced Solid Tumors",
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      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT03843515",
      "title": "Neoadjuvant Nivolumab for Oral Cancer Combined With FDG and Anti-PD-L1 PET/CT Imaging for Response Prediction",
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      "last_update": "2021-10-08",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT03854032",
      "title": "Nivolumab and BMS986205 in Treating Patients With Stage II-IV Squamous Cell Cancer of the Head and Neck",
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      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT03878979",
      "title": "Preoperative Immune Checkpoint Inhibitor for Patients With Primary Untreated or Recurrent/Metastatic SCCHN",
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      "last_update": "2024-11-21",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03894891",
      "title": "Induction TPN Followed by Nivolumab With Radiation in Locoregionally Advanced Laryngeal and Hypopharyngeal Cancer",
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      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03906526",
      "title": "A Study to Evaluate Immune Biomarker Modulation in Response to VTX-2337 in Combination With an Anti- PD-1 Inhibitor in Head and Neck Cancer",
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      "last_update": "2023-02-24",
      "phase": "PHASE1",
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     {
      "nct": "NCT03914300",
      "title": "Testing the Combination of Cabozantinib, Nivolumab, and Ipilimumab (CaboNivoIpi) for Advanced Differentiated Thyroid Cancer",
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      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03914443",
      "title": "A Feasibility Trial of Nivolumab With Neoadjuvant CF or DCF Therapy for Locally Advanced Esophageal Carcinoma",
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      "last_update": "2025-05-31",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03952585",
      "title": "De-intensified Radiation Therapy With Chemotherapy (Cisplatin) or Immunotherapy (Nivolumab) in Treating Patients With Early-Stage, HPV-Positive, Non-Smoking Associated Oropharyngeal Cancer",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-07-02",
      "phase": "PHASE2/PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03970382",
      "title": "A Study of Gene Edited Autologous Neoantigen Targeted TCR T Cells With or Without Anti-PD-1 in Patients With Solid Tumors",
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      "last_update": "2022-08-18",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03984357",
      "title": "Nivolumab Combined With Chemoradiotherapy Sparing Concurrent Cisplatin in Nasopharyngeal Carcinoma",
      "status": "COMPLETED",
      "last_update": "2025-07-17",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03987815",
      "title": "Neoadjuvant Nivolumab for Operable Esophageal Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2020-12-17",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03993353",
      "title": "Tadalafil and Pembrolizumab in Recurrent or Metastatic Head and Neck Cancer",
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      "last_update": "2026-02-12",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04044859",
      "title": "ADP-A2M4CD8 as Monotherapy or in Combination With Either Nivolumab or Pembrolizumab in HLA-A2+ Subjects With MAGE-A4 Positive Tumors (SURPASS)",
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      "last_update": "2026-08-12",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04061980",
      "title": "Encorafenib and Binimetinib With or Without Nivolumab in Treating Patients With Metastatic Radioiodine Refractory BRAF V600 Mutant Thyroid Cancer",
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      "last_update": "2026-04-13",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04074967",
      "title": "Study of ARRY-614 Plus Either Nivolumab or Nivolumab+Ipilimumab",
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      "last_update": "2025-11-06",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT04080804",
      "title": "Study of Safety and Tolerability of Nivolumab Treatment Alone or in Combination With Relatlimab or Ipilimumab in Head and Neck Cancer",
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      "last_update": "2026-09-09",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04084951",
      "title": "Study of SQZ-PBMC-HPV in Patients With HPV16+ Recurrent, Locally Advanced or Metastatic Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2023-04-14",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT04157985",
      "title": "Evaluating Length of Treatment With PD-1/PD-L1 Inhibitor in Advanced Solid Tumors",
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      "last_update": "2025-12-11",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT04180371",
      "title": "Study BT5528-100 in Patients With Advanced Solid Tumors Associated With EphA2 Expression",
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      "last_update": "2025-11-17",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT04229459",
      "title": "Trial of Nivolumab and Cetuximab After Chemoradiation in Esophageal Squamous Cell Carcinoma Patients.",
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      "last_update": "2026-01-14",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT04278144",
      "title": "A First-in-human Study Using BDC-1001 as a Single Agent and in Combination With Nivolumab in Advanced HER2-Expressing Solid Tumors",
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      "last_update": "2025-09-15",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT04282109",
      "title": "Study to Assess the Efficacy and Safety of Nivolumab in Combination With Paclitaxel in Subjects With Head and Neck Cancer Unable for Cisplatin-based Chemotherapy (NIVOTAX)",
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      "last_update": "2025-06-26",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT04326257",
      "title": "Personalized Immunotherapy in Patients With Recurrent /Metastatic SCCHN That Have Progressed on Prior Immunotherapy",
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      "last_update": "2026-01-08",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT04349267",
      "title": "Study of BMS-986315 Alone and in Combination With Nivolumab or Cetuximab in Participants With Advanced Solid Tumors",
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      "last_update": "2025-12-17",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT04458909",
      "title": "Testing the Addition of an Anti-cancer Immune Therapy Drug (Nivolumab) to the Usual Chemotherapy Treatment (Cisplatin or Carboplatin With Gemcitabine) for Recurrent or Metastatic Nasopharyngeal Cancer",
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      "last_update": "2025-10-03",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT04503967",
      "title": "Efficacy and Safety of Anlotinib Hydrochloride Combined With Nivolumab in the Treatment of Gastric and Esophageal Cancer",
      "status": "UNKNOWN",
      "last_update": "2020-08-07",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT04514484",
      "title": "Testing the Combination of the Anti-cancer Drugs XL184 (Cabozantinib) and Nivolumab in Patients With Advanced Cancer and HIV",
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      "last_update": "2026-05-28",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT04570839",
      "title": "COM701 in Combination With BMS-986207 and Nivolumab in Subjects With Advanced Solid Tumors.",
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      "last_update": "2024-07-18",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT04603248",
      "title": "A Study for Identification of Immune Determinants for Response to Nivolumab in Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma",
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      "last_update": "2026-06-10",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT04624113",
      "title": "Tazemetostat and Pembrolizumab in Patients With Pembrolizumab- or Nivolumab-Resistant, Recurrent or Metastatic Head and Neck Squamous-Cell Carcinoma",
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      "last_update": "2024-02-21",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT04659369",
      "title": "Study of Pharmacokinetic, Safety, Immunogenicity and Efficacy of CMAB819 and Nivolumab in R/M HNSCC",
      "status": "TERMINATED",
      "last_update": "2024-04-09",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT04704154",
      "title": "A Trial to Learn Whether Regorafenib in Combination With Nivolumab Can Improve Tumor Responses and How Safe it is for Participants With Solid Tumors",
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      "last_update": "2025-04-18",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT04731467",
      "title": "A Study of CM24 in Combination with Nivolumab in Adults with Advanced Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2024-12-27",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT04757363",
      "title": "A Study of Nivolumab Combined With FOLFOX and Regorafenib in People Who Have HER2-Negative Esophagogastric Cancer",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-03-04",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04785820",
      "title": "A Study of Lomvastomig (RO7121661) and Tobemstomig (RO7247669) Compared With Nivolumab in Participants With Advanced or Metastatic Squamous Cell Carcinoma of the Esophagus",
      "status": "COMPLETED",
      "last_update": "2026-03-27",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04831320",
      "title": "Nab-Paclitaxel in Combination With Nivolumab to Treat Recurrent or Metastatic Head and Neck Squamous-Cell Carcinoma That Progressed on a PD-1 or PD-L1 Inhibitor",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-07-06",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04848116",
      "title": "Neoadjuvant Targeting of Myeloid Cell Populations in Combination With Nivolumab in Head & Neck Ca",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-05-14",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04891718",
      "title": "CIVO Intratumoural Microdosing of Anti-Cancer Therapies in Australia",
      "status": "WITHDRAWN",
      "last_update": "2022-07-08",
      "phase": "EARLY_PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04892043",
      "title": "Study of SQZ-AAC-HPV in Patients With HPV16+ Recurrent, Locally Advanced or Metastatic Solid Tumors",
      "status": "TERMINATED",
      "last_update": "2024-02-23",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04925284",
      "title": "Study of XB002 in Subjects With Solid Tumors (JEWEL-101)",
      "status": "COMPLETED",
      "last_update": "2025-04-04",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04943900",
      "title": "A Study of BMS-986416 With and Without Nivolumab in Select Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2025-04-09",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04984733",
      "title": "Temozolomide + Nivolumab in MGMT Methylated Oesophagogastric Cancer",
      "status": "COMPLETED",
      "last_update": "2026-05-18",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05027204",
      "title": "A Study of Docetaxel for Injection (Albumin-bound) in Combination With Nivolumab in Patients With Head and Neck (SCCHN)",
      "status": "UNKNOWN",
      "last_update": "2022-10-13",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05069935",
      "title": "FT538 in Combination With Monoclonal Antibodies in Advanced Solid Tumors",
      "status": "TERMINATED",
      "last_update": "2023-09-21",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05213312",
      "title": "Study of Neoadjuvant Nivolumab or Placebo Plus Chemotherapy Followed by Surgery and Adjuvant Treatment in Subjects With Resectable ESCC",
      "status": "UNKNOWN",
      "last_update": "2022-06-15",
      "phase": "PHASE2/PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05280457",
      "title": "HPV 16-positive and/or HPV 18-positive Recurrent and/or For Patients With Metastatic Head and Neck Cancer to Evaluate GX-188E DNA Vaccination, GX-I7 and Nivolumab Combination Therapy",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-06-11",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05327270",
      "title": "Non-randomized, Open-label Study of Intralesional Nivolumab for High Risk Oral Premalignant Lesions",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-06-12",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05395052",
      "title": "FT536 Monotherapy and in Combination With Monoclonal Antibodies in Advanced Solid Tumors",
      "status": "TERMINATED",
      "last_update": "2023-09-21",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05429866",
      "title": "Immunological Variables Associated to ICI Toxicity in Cancer Patients",
      "status": "UNKNOWN",
      "last_update": "2023-03-08",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05472506",
      "title": "Oral AHR Antagonist in Combination With Nivolumab in Patients With PD-1 Resistant Metastatic or Recurrent Head and Neck Cancer",
      "status": "WITHDRAWN",
      "last_update": "2024-03-15",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05480384",
      "title": "Adjuvant Trastuzumab Deruxtecan (Enhertu) & Nivolumab For Patients Who Are Disease Free After Completion of Trimodality Treatment For HER-2+ Cancers of Esophagus & Gastroesophageal Junction",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-04-21",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05491616",
      "title": "Nivolumab During Active Surveillance After Neoadjuvant Chemoradiation for Esophageal Cancer: SANO-3 Study",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-02-13",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05655663",
      "title": "Evaluation of Vascular Toxicity of Immune Checkpoint Inhibitors in Patients Head and Neck or Lung Cancer",
      "status": "UNKNOWN",
      "last_update": "2022-12-19",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05704985",
      "title": "Evaluating Safety and Biomarkers Using DK210 (EGFR) for Locally Advanced or Metastatic EGFR+ Tumors",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-05-29",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05743270",
      "title": "Study of RP3 in Combination With Nivolumab and Other Therapy in Patients With Locoregionally Advanced or Recurrent SCCHN",
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      "title": "The Effect of Prebiotic Inulin on Patients Affected by R/M HNSCC Treated With Immune Checkpoint Inhibitors",
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      "title": "Phase I/II Evaluation of a Cancer Lysate Vaccine and Montanide(R) ISA-51 VG With Entinostat and Nivolumab as Adjuvant Therapy Following Chemoradiation Therapy With or Without Surgery for Locally Advanced Esophageal Cancer",
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      "title": "Nivolumab Combined With Chemotherapy in the Treatment of Primary Tracheal Squamous Cell Carcinoma",
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      "title": "Evaluating the Use of Dual Imaging Techniques for Detection of Disease in Patients With Head and Neck Cancer",
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     {
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      "title": "Window Trial of Fluorescently Labeled Panitumumab (Panitumumab-IRDye800) in Head and Neck Cancer",
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      "title": "Monoclonal Antibody ABX-EGF in Treating Patients With Renal (Kidney), Prostate, Pancreatic, Non-Small Cell Lung, Colon or Rectal, Esophageal, or Gastroesophageal Junction Cancer",
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     {
      "nct": "NCT00101907",
      "title": "Safety of AMG 706 Plus Panitumumab Plus Gemcitabine-Cisplatin in the Treatment of Patients With Advanced Cancer",
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      "title": "PRISM (Panitumumab Regimen In Second-line Monotherapy of Head and Neck Cancer)",
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      "title": "PARTNER: Panitumumab Added to Regimen for Treatment of Head aNd Neck Cancer Evaluation of Response",
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      "title": "Study of Panitumumab Efficacy in Patients With Recurrent and/or Metastatic Head and Neck Cancer",
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      "title": "Study of Addition of Panitumumab to Chemoradiation Therapy in Patients With Locally Advanced Head and Neck Cancer",
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      "title": "Panitumumab Chemoradiotherapy Chemotherapy for Squamous Cancer of the Head and Neck",
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      "title": "Radiotherapy Plus Panitumumab Compared to Chemoradiotherapy With Unresected, Locally Advanced Squamous Cell Carcinoma of the Head and Neck",
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      "phase": "PHASE2",
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     {
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      "title": "Phase I/II Study of Panitumumab, Capecitabine and Oxaliplatin w EBRT for Esophageal Cancer",
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     {
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      "title": "A Randomized Phase 2 Pharmacokinetic Trial of Chemotherapy With or Without Panitumumab in Patients With Metastatic and/or Recurrent Squamous Cell Carcinoma of the Head and Neck",
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      "nct": "NCT00757172",
      "title": "Panitumumab, Docetaxel, Cisplatin, Radiation Therapy, and Surgery in Treating Patients With Newly Diagnosed, Locally Advanced Esophageal Cancer or Cancer of the Gastroesophageal Junction",
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      "phase": "PHASE2",
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     {
      "nct": "NCT00798655",
      "title": "Trial of Postoperative Radiation, Cisplatin, and Panitumumab in Locally Advanced Head and Neck Cancer",
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      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT00820248",
      "title": "Radiation + Cisplatin or Panitumumab in Locally Advanced Stage III or Stage IV Head and Neck Cancer",
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      "phase": "PHASE3",
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     {
      "nct": "NCT00836277",
      "title": "Phase II Study of Irinotecan and Panitumumab",
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      "last_update": "2016-11-15",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT01077999",
      "title": "Chemoradiation and Panitumumab for Esophageal Cancer",
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      "last_update": "2021-04-21",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT01128387",
      "title": "Trial of Panitumumab/Cisplatin/Fluorouracil Combined With Radiation in Esophageal Cancer",
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      "last_update": "2019-12-09",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT01142414",
      "title": "Chemotherapy and Radiation Therapy With or Without Panitumumab in Treating Patients Who Have Undergone Surgery for Advanced Hypopharyngeal Cancer, Oropharyngeal Cancer, Laryngeal Cancer, or Oral Cavity Cancer at High Risk of Recurrence",
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      "last_update": "2012-01-16",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT01221753",
      "title": "Docetaxel/Cisplatin/5-Fluorouracil (TPF) Human Papillomavirus (HPV) Squamous Cell Carcinoma Study",
      "status": "TERMINATED",
      "last_update": "2017-12-06",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT01262183",
      "title": "Radio-chemotherapy With or Without Panitumumab (Vectibix\u00ae) in Irresectable Squamous Cell Carcinoma or Adenocarcinoma of the Oesophagus",
      "status": "TERMINATED",
      "last_update": "2012-05-11",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT01264328",
      "title": "Study of the Combination of Panitumumab With Paclitaxel as First-line Treatment of Subjects With Head and Neck Cancer",
      "status": "COMPLETED",
      "last_update": "2019-04-16",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT01305772",
      "title": "Identification of Gene Expression Signature for Panitumumab Sensitivity in Untreated Locally Advanced SCCHN",
      "status": "TERMINATED",
      "last_update": "2014-08-29",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01307956",
      "title": "Panitumumab, Combination Chemotherapy, & Radiation Therapy in Esophageal or Gastroesophageal Junction Cancer",
      "status": "TERMINATED",
      "last_update": "2023-10-26",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01312493",
      "title": "Selective IMRT for Locally Advanced Head and Neck Carcinoma With Concurrent Panitumumab",
      "status": "WITHDRAWN",
      "last_update": "2015-08-28",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01443065",
      "title": "MEGA (Met or EGFR Inhibition in Gastroesophageal Adenocarcinoma): FOLFOX Alone or in Combination With AMG 102 or Panitumumab as First-line Treatment in Patients With Advanced Gastroesophageal Adenocarcinoma",
      "status": "COMPLETED",
      "last_update": "2020-11-17",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01627379",
      "title": "Cisplatin and 5-FU +/- Panitumumab for Patients With Nonresectable,Advanced or Metastatic Esophageal Squamous Cell Cancer",
      "status": "TERMINATED",
      "last_update": "2018-03-02",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
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     {
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      "title": "Study of Safety and Efficacy of INC280 and Cetuximab, in Adult c-MET Positive mCRC and HNSCC Patients After Progression on Cetuximab or Panitumumab Therapy",
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      "title": "Study to Investigate the Efficacy of Panitumumab in Platinum-resistant Advanced Head and Neck Squamous Cancer",
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      "title": "Panitumumab-IRDye800 Compared to Sentinel Node Biopsy and (Selective) Neck Dissection in Identifying Metastatic Lymph Nodes in Patients With Head&Neck Cancer",
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      "title": "Panitumumab-IRDye800 and 89Zr-Panitumumab in Identifying Metastatic Lymph Nodes in Patients With Squamous Cell Head and Neck Cancer",
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      "title": "Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis",
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      "title": "A Study of ASP-1929 Photoimmunotherapy in Combination With Pembrolizumab in First-line Treatment of Locoregional Recurrent Squamous Cell Carcinoma of the Head and Neck With No Distant Metastases",
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      "title": "FORTIFI-HN01: A Study of Ficerafusp Alfa (BCA101) or Placebo in Combination With Pembrolizumab in First-Line PD-L1-pos, R or M HNSCC",
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      "title": "TMV Vaccine Therapy Alone and With Pembrolizumab for the Treatment of Recurrent and/or Metastatic Head and Neck Squamous Cell Cancer",
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      "title": "Optimizing Neoadjuvant Treatment Regimens for Locally Advanced Esophageal Squamous Cell Carcinoma",
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      "title": "Dose Finding Study of Zanzalintinib With Pembrolizumab and Cetuximab in Head and Neck SCC",
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      "title": "CUE-101with Pembrolizumab for Locally Advanced HPV+HNSCCs",
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      "nct": "NCT07213934",
      "title": "Phase I/ II Trial Combining PD-1 Inhibition and Neoadjuvant Proton or Photon Radiation Therapy in Recurrent Head and Neck Squamous Cell Carcinoma",
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      "nct": "NCT07223424",
      "title": "Patient Preference for Subcutaneous vs. Intravenous Immune Therapy",
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      "last_update": "2026-04-16",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT07343596",
      "title": "Study to Identify Biomarkers of Oral Cavity Cancer Response to Neoadjuvant Immunotherapy Prior to Definitive Surgery",
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      "last_update": "2026-08-10",
      "phase": "NA",
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      "nct": "NCT07403136",
      "title": "Becotatug Vedotin \u00b1 Anti-PD-1 in Pretreated Advanced ESCC",
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      "last_update": "2026-07-07",
      "phase": "PHASE2",
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     {
      "nct": "NCT07405151",
      "title": "A Clinical Trial of Ifinatamab Deruxtecan in People With Advanced Esophageal Cancer (MK-3475-06F)",
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      "last_update": "2026-09-03",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT07410676",
      "title": "EBNK-001 Allogeneic NK Cells With Low-Dose IL-15 \u00b1 Pembrolizumab in Advanced Solid Tumors",
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      "last_update": "2026-02-18",
      "phase": "PHASE1/PHASE2",
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     {
      "nct": "NCT07455019",
      "title": "A Study of Bemosubaiabimab Combined With Anlotinib and Radiotherapy and Chemotherapy for the Treatment of Oligometastatic Esophageal Cancer",
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      "last_update": "2026-03-06",
      "phase": "PHASE2",
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     {
      "nct": "NCT07485296",
      "title": "Effect of Postbiotics on Microbiota and Systemic Immunomodulation of Pembrolizumab as First-Line Therapy in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma (RM HNSCC)",
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      "last_update": "2026-03-20",
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      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT07501650",
      "title": "Pembrolizumab Plus Ultrasound-Induced Microbubble Cavitation in Head and Neck Cancer",
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      "last_update": "2026-03-30",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT02376699",
      "title": "Safety Study of SEA-CD40 in Cancer Patients",
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      "last_update": "2023-05-01",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT02475213",
      "title": "Safety Study of Enoblituzumab (MGA271) in Combination With Pembrolizumab or MGA012 in Refractory Cancer",
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      "last_update": "2025-08-11",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT02538510",
      "title": "Pembrolizumab and Vorinostat in Treating Patients With Recurrent Squamous Cell Head and Neck Cancer or Salivary Gland Cancer That Is Metastatic and/or Cannot Be Removed by Surgery",
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      "last_update": "2024-11-26",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT02559687",
      "title": "Study of Pembrolizumab (MK-3475) in Previously-Treated Participants With Advanced Carcinoma of the Esophagus or Esophagogastric Junction (MK-3475-180/KEYNOTE-180)",
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     {
      "nct": "NCT02575404",
      "title": "GR-MD-02 Plus Pembrolizumab in Melanoma, Non-small Cell Lung Cancer, and Squamous Cell Head and Neck Cancer Patients",
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      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT02609503",
      "title": "Pembrolizumab + Radiation for Locally Adv SCC of the Head and Neck (SCCHN) Not Eligible Cisplatin",
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      "study_type": "INTERVENTIONAL"
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      "nct": "NCT02626000",
      "title": "Talimogene Laherparepvec With Pembrolizumab for Recurrent Metastatic Squamous Cell Carcinoma of the Head and Neck (MASTERKEY232 / KEYNOTE-137)",
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      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT02641093",
      "title": "Phase II Trial of Adjuvant Cisplatin and Radiation With Pembrolizumab in Resected Head and Neck Squamous Cell Carcinoma",
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      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT02707588",
      "title": "Tolerance and Efficacy of Pembrolizumab or Cetuximab Combined With RT in Patients With Locally Advanced HNSCC",
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      "last_update": "2023-02-28",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT02757391",
      "title": "CD8+ T Cell Therapy and Pembrolizumab in Treating Patients With Metastatic Gastrointestinal Tumors",
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      "last_update": "2020-10-30",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT02775812",
      "title": "Cisplatin, Intensity-Modulated Radiation Therapy, and Pembrolizumab in Treating Patients With Stage III-IV Head and Neck Squamous Cell Carcinoma",
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      "last_update": "2022-06-10",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT02799095",
      "title": "A Study of the Effects of ALKS 4230 (Nemvaleukin Alfa) on Subjects With Solid Tumors",
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      "last_update": "2025-05-21",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT02830594",
      "title": "Pembrolizumab and Palliative Radiation Therapy in Treating Patients With Metastatic Esophagus, Stomach, or Gastroesophageal Junction Cancer",
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      "last_update": "2024-02-20",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02841748",
      "title": "A Randomized, Double-Blind Phase II Study of Adjuvant Pembrolizumab Versus Placebo in Head and Neck Cancers at High Risk for Recurrence- the PATHWay Study",
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      "last_update": "2026-05-13",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT02882282",
      "title": "Pembrolizumab in Treating Patients With High Risk Oral Intraepithelial Neoplasia",
      "status": "COMPLETED",
      "last_update": "2025-10-23",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02903914",
      "title": "Arginase Inhibitor INCB001158 as a Single Agent and in Combination With Immune Checkpoint Therapy in Patients With Advanced/Metastatic Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2025-08-05",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02952989",
      "title": "A Safety Study of SGN-2FF for Patients With Advanced Solid Tumors",
      "status": "TERMINATED",
      "last_update": "2019-07-19",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02955290",
      "title": "CIMAvax Vaccine, Nivolumab, and Pembrolizumab in Treating Patients With Advanced Non-small Cell Lung Cancer or Squamous Head and Neck Cancer",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-08-10",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02971956",
      "title": "Pembrolizumab in Refractory Advanced Esophageal Cancer",
      "status": "COMPLETED",
      "last_update": "2023-09-21",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02973997",
      "title": "Lenvatinib and Pembrolizumab in Differentiated Thyroid Cancers (DTC)",
      "status": "COMPLETED",
      "last_update": "2025-08-29",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03006887",
      "title": "Phase 1b Trial of Lenvatinib Plus Pembrolizumab in Participants With Selected Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2021-05-20",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03040999",
      "title": "Study of Pembrolizumab (MK-3475) or Placebo With Chemoradiation in Participants With Locally Advanced Head and Neck Squamous Cell Carcinoma (MK-3475-412/KEYNOTE-412)",
      "status": "COMPLETED",
      "last_update": "2026-02-04",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03058289",
      "title": "A Phase 1/2 Safety Study of Intratumorally Dosed INT230-6",
      "status": "COMPLETED",
      "last_update": "2025-02-27",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03129061",
      "title": "Study to Evaluate Immunological Response to PD-1 Inhibition in Squamous Cell Carcinoma of the Head and Neck (SCCHN)",
      "status": "COMPLETED",
      "last_update": "2022-12-05",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03189719",
      "title": "First-line Esophageal Carcinoma Study With Pembrolizumab Plus Chemo vs. Chemo (MK-3475-590/KEYNOTE-590)",
      "status": "COMPLETED",
      "last_update": "2024-10-15",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03196232",
      "title": "Epacadostat and Pembrolizumab in Treating Patients With Metastatic or Unresectable Gastroesophageal Junction or Gastric Cancer",
      "status": "COMPLETED",
      "last_update": "2024-01-23",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03236935",
      "title": "Phase Ib of L-NMMA and Pembrolizumab",
      "status": "COMPLETED",
      "last_update": "2026-04-09",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03238638",
      "title": "A Study of Epacadostat + Pembrolizumab in Head and Neck Cancer Patients, Who Failed Prior PD-1/PD-L1 Therapy",
      "status": "WITHDRAWN",
      "last_update": "2018-01-04",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03313804",
      "title": "Priming Immunotherapy in Advanced Disease With Radiation",
      "status": "COMPLETED",
      "last_update": "2026-03-11",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03329950",
      "title": "A Study of CDX-1140 (CD40) as Monotherapy or in Combination in Patients With Advanced Malignancies",
      "status": "COMPLETED",
      "last_update": "2024-03-28",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03342937",
      "title": "KeyLargo: Pembrolizumab + Oxaliplatin + Capecitabine in Gastric Cancer",
      "status": "COMPLETED",
      "last_update": "2024-03-13",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03360890",
      "title": "Pembrolizumab With Chemotherapy for Poorly Chemo-responsive Thyroid and Salivary Gland Tumors",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-03-13",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03383094",
      "title": "Chemoradiation vs Immunotherapy and Radiation for Head and Neck Cancer",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-10-07",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03386357",
      "title": "Radiotherapy With Pembrolizumab in Metastatic Head and Neck Squamous Cell Carcinoma (HNSCC)",
      "status": "TERMINATED",
      "last_update": "2026-03-27",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03463161",
      "title": "Epacadostat and Pembrolizumab in Patients With Head and Neck Cancer That Have Failed Prior Immunotherapy",
      "status": "TERMINATED",
      "last_update": "2020-01-27",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03474497",
      "title": "UCDCC#272: IL-2, Radiotherapy, and Pembrolizumab in Patients Refractory to Checkpoint Blockade",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-01-29",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03511391",
      "title": "CHEckpoint Inhibition in Combination With an Immunoboost of External Beam Radiotherapy in Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2024-01-23",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03544723",
      "title": "Safety and Efficacy of p53 Gene Therapy Combined With Immune Checkpoint Inhibitors in Solid Tumors.",
      "status": "UNKNOWN",
      "last_update": "2020-06-09",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03592407",
      "title": "Epacadostat and Pembrolizumab Before Surgery in Treating Participants With Stage II-III Esophageal or Gastroesophageal Cancer",
      "status": "WITHDRAWN",
      "last_update": "2022-03-08",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03621982",
      "title": "Study of ADCT-301 in Patients With Selected Advanced Solid Tumors",
      "status": "TERMINATED",
      "last_update": "2024-06-13",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03625323",
      "title": "Combination Study With Soluble LAG-3 Fusion Protein Eftilagimod Alpha (IMP321) and Pembrolizumab in Patients With Previously Untreated Unresectable or Metastatic NSCLC, or Recurrent PD-X Refractory NSCLC or With Recurrent or Metastatic HNSCC",
      "status": "COMPLETED",
      "last_update": "2026-04-22",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03633110",
      "title": "Safety, Tolerability, Immunogenicity, and Antitumor Activity of GEN-009 Adjuvanted Vaccine",
      "status": "COMPLETED",
      "last_update": "2022-04-19",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03645928",
      "title": "Study of Autologous Tumor Infiltrating Lymphocytes in Patients With Solid Tumors",
      "status": "TERMINATED",
      "last_update": "2026-05-15",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03674567",
      "title": "Dose Escalation and Expansion Study of FLX475 Monotherapy and in Combination With Pembrolizumab",
      "status": "COMPLETED",
      "last_update": "2026-09-03",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03684785",
      "title": "Intratumoral Cavrotolimod Combined With Pembrolizumab or Cemiplimab in Patients With Merkel Cell Carcinoma, Cutaneous Squamous Cell Carcinoma, or Other Advanced Solid Tumors",
      "status": "TERMINATED",
      "last_update": "2022-04-07",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03735290",
      "title": "A Study to Evaluate the Safety and Effectiveness of ILIxadencel Administered Into Tumors in Combination With Checkpoint Inhibitor (CPI) in Patients With ADvanced Cancer",
      "status": "TERMINATED",
      "last_update": "2022-03-16",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03765918",
      "title": "Study of Pembrolizumab Given Prior to Surgery and in Combination With Radiotherapy Given Post-surgery for Advanced Head and Neck Squamous Cell Carcinoma (MK-3475-689)",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-07-31",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03769467",
      "title": "Tabelecleucel in Combination With Pembrolizumab in Subjects With Epstein-Barr Virus-associated Nasopharyngeal Carcinoma (EBV+ NPC)",
      "status": "TERMINATED",
      "last_update": "2024-11-14",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03789097",
      "title": "Vaccination With Flt3L, Radiation, and Poly-ICLC",
      "status": "COMPLETED",
      "last_update": "2026-05-22",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03792347",
      "title": "Preoperative Anti-PD-1 Antibody Combined With Chemoradiotherapy for Locally Advanced Squamous Cell Carcinoma of Esophagus",
      "status": "COMPLETED",
      "last_update": "2023-11-22",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03799003",
      "title": "A Study of ASP1951 in Subjects With Advanced Solid Tumors",
      "status": "TERMINATED",
      "last_update": "2024-11-01",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03809624",
      "title": "Study of INBRX-105 and INBRX-105 With Pembrolizumab in Patients With Solid Tumors Including Head and Neck Cancer",
      "status": "TERMINATED",
      "last_update": "2024-10-23",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03813836",
      "title": "Phase II Trial of Pembrolizumab in Recurrent or Metastatic HNSCC",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2024-11-12",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03823131",
      "title": "Optimizing Antitumor Immunity Using Plasmid Electroporation, Pembrolizumab, and Epacadostat",
      "status": "TERMINATED",
      "last_update": "2023-05-09",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03881111",
      "title": "First-line Esophageal Carcinoma Study With Chemo vs. Chemo Plus Pembrolizumab (MK-3475-590/KEYNOTE-590)-China Extension Study",
      "status": "WITHDRAWN",
      "last_update": "2020-02-11",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03933449",
      "title": "Study of Pembrolizumab (MK-3475) Versus Investigator's Choice of Chemotherapy for Participants With Advanced Esophageal/Esophagogastric Junction Carcinoma That Progressed After First-Line Therapy (MK-3475-181/KEYNOTE-181)-China Extension Study",
      "status": "COMPLETED",
      "last_update": "2023-03-29",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03938337",
      "title": "Abemaciclib and Pembrolizumab in Metastatic or Recurrent Head and Neck Cancer",
      "status": "TERMINATED",
      "last_update": "2021-07-09",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04007744",
      "title": "Sonidegib and Pembrolizumab in Treating Patients With Advanced Solid Tumors",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-03-18",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04030455",
      "title": "Cisplatin, Docetaxel, and Pembrolizumab in Treating Patients With Stage II-III Laryngeal Cancer",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-03-09",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04032704",
      "title": "A Study of Ladiratuzumab Vedotin in Advanced Solid Tumors",
      "status": "TERMINATED",
      "last_update": "2025-03-10",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04044859",
      "title": "ADP-A2M4CD8 as Monotherapy or in Combination With Either Nivolumab or Pembrolizumab in HLA-A2+ Subjects With MAGE-A4 Positive Tumors (SURPASS)",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-08-12",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04058145",
      "title": "AMD3100 Plus Pembrolizumab in Immune Checkpoint Blockade Refractory Head and Neck Squamous Cell Carcinoma",
      "status": "WITHDRAWN",
      "last_update": "2020-09-07",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04083599",
      "title": "GEN1042 Safety Trial and Anti-tumor Activity in Participants With Malignant Solid Tumors",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-08-04",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04140526",
      "title": "Safety, PK and Efficacy of ONC-392 in Monotherapy and in Combination of Anti-PD-1 in Advanced Solid Tumors and NSCLC",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-05-23",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04150900",
      "title": "1922GCCC: Pembro and Bavituximab for Squamous Cell Carcinoma of Head and Neck",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-02-19",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04157985",
      "title": "Evaluating Length of Treatment With PD-1/PD-L1 Inhibitor in Advanced Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2025-12-11",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04187872",
      "title": "LITT and Pembrolizumab in Recurrent Brain Metastasis",
      "status": "TERMINATED",
      "last_update": "2023-12-27",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04199104",
      "title": "A Study of Pembrolizumab (MK-3475) With or Without Lenvatinib (E7080/MK-7902) as First Line (1L) Intervention in a Programmed Cell Death-ligand 1 (PD-L1) Selected Population With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma (R/M HNSCC) (MK-7902-010) (KEYNOTE-010)",
      "status": "COMPLETED",
      "last_update": "2026-05-05",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04209660",
      "title": "Lenvatinib and Pembrolizumab in People With Advanced Adenoid Cystic Carcinoma and Other Salivary Gland Cancers",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-10-07",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04222972",
      "title": "A Study of Pralsetinib Versus Standard of Care for First-Line Treatment of Advanced Non-Small Cell Lung Cancer (NSCLC)",
      "status": "TERMINATED",
      "last_update": "2026-03-05",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04260126",
      "title": "Study of PDS0101 and Pembrolizumab Combination I/O in Subjects With HPV16 + Recurrent and/or Metastatic HNSCC",
      "status": "COMPLETED",
      "last_update": "2025-10-01",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04266730",
      "title": "Trial of a Personalized and Adaptive Neoantigen Dose-Adjusted Vaccine Concurrently With Pembrolizumab",
      "status": "SUSPENDED",
      "last_update": "2026-04-23",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04305795",
      "title": "An Open-label Study Using ASP-1929 Photoimmunotherapy in Combination With Anti-PD1 Therapy in EGFR Expressing Advanced Solid Tumors",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-06-19",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04340258",
      "title": "Trial Combining Pembrolizumab and Cesium 131 Brachytherapy With Salvage Surgery in HNSCC",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-06-09",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04354246",
      "title": "COM902 (A TIGIT Inhibitor) in Subjects With Advanced Malignancies",
      "status": "COMPLETED",
      "last_update": "2026-08-12",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04357873",
      "title": "Efficacy of Immunotherapy Plus a Drug in Patients With Progressive Advanced Mucosal Cancer of Different Locations",
      "status": "COMPLETED",
      "last_update": "2025-02-19",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04369937",
      "title": "HPV-16 Vaccination and Pembrolizumab Plus Cisplatin for \"Intermediate Risk\" HPV-16-associated Head and Neck Squamous Cell Carcinoma",
      "status": "COMPLETED",
      "last_update": "2026-05-13",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04379596",
      "title": "Ph1b/2 Study of the Safety and Efficacy of T-DXd Combinations in Advanced HER2-expressing Gastric Cancer (DESTINY-Gastric03)",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-08-28",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04389177",
      "title": "Pembrolizumab Plus Paclitaxel, Cisplatin Followed by Surgery for Locally Advanced ESCC (KEYSTONE-001)",
      "status": "UNKNOWN",
      "last_update": "2023-04-10",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04428151",
      "title": "Lenvatinib (E7080/MK-7902) in Combination With Pembrolizumab (MK-3475) vs. Standard Chemotherapy and Lenvatinib Monotherapy in Participants With Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma That Progressed After Platinum Therapy and Immunotherapy (MK-7902-009/E7080-G000-228/LEAP-009)",
      "status": "COMPLETED",
      "last_update": "2025-12-04",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04430738",
      "title": "Tucatinib Plus Trastuzumab and Oxaliplatin-based Chemotherapy or Pembrolizumab-containing Combinations for HER2+ Gastrointestinal Cancers",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-02-24",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04452214",
      "title": "A Study of the Safety and Tolerance of CAN04 and Pembrolizumab in Combination With and Without Carboplatin and Pemetrexed in Subjects With Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2023-07-14",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04454489",
      "title": "Quad Shot Radiotherapy in Combination With Immune Checkpoint Inhibition",
      "status": "COMPLETED",
      "last_update": "2025-11-19",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04485013",
      "title": "TTX-080 HLA-G Antagonist in Subjects With Advanced Cancers",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-09-11",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04510285",
      "title": "A Single-Arm Pilot Study of Adjuvant Pembrolizumab Plus Trastuzumab in HER2+ Esophagogastric Tumors With Persistent Circulating Tumor DNA Following Curative Resection",
      "status": "TERMINATED",
      "last_update": "2023-02-01",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04541108",
      "title": "Phase 0 Master Protocol for CIVO Intratumoral Microdosing of Anti-Cancer Therapies",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-05-22",
      "phase": "EARLY_PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04555837",
      "title": "Alisertib and Pembrolizumab for the Treatment of Patients With Rb-deficient Head and Neck Squamous Cell Cancer",
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      "nct": "NCT04609566",
      "title": "Brentuximab Vedotin With Pembrolizumab in Metastatic Solid Tumors",
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      "title": "Olaparib in Combination With Pembrolizumab and Carboplatin as First-Line Treatment of Recurrent or Metastatic Head and Neck Squamous-Cell Carcinoma",
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      "title": "CAR-macrophages for the Treatment of HER2 Overexpressing Solid Tumors",
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      "title": "A Dose Escalation/Expansion Study of ERAS-601 in Patients With Advanced or Metastatic Solid Tumors",
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      "title": "A Phase 1a/1b FIH Study of PY159 and in Combination With Pembrolizumab in Subjects With Advanced Solid Tumors",
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      "nct": "NCT04731740",
      "title": "Pembrolizumab and Lenvatinib/Chemotherapy for Poorly Differentiated/Anaplastic Thyroid Cancer",
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      "title": "Combination Study With Eftilagimod Alpha (a Soluble LAG-3 Fusion Protein) and Pembrolizumab in Patients With Recurrent or Metastatic HNSCC",
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      "nct": "NCT04825990",
      "title": "Pembrolizumab and Olaparib in Recurrent/Metastatic, Platinum Resistant Nasopharyngeal Cancer",
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      "nct": "NCT04830592",
      "title": "A Study of NG-641 and Pembrolizumab in Squamous Cell Carcinoma of the Head and Neck",
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      "title": "NBTXR3, Radiation Therapy, and Pembrolizumab for the Treatment of Recurrent or Metastatic Head and Neck Squamous Cell Cancer",
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      "title": "A Study of TAK-676 With Pembrolizumab After Radiation Therapy to Treat a Number of Cancers",
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      "nct": "NCT04913337",
      "title": "Study of NGM707 As Monotherapy and in Combination with Pembrolizumab in Advanced or Metastatic Solid Tumor Malignancies",
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      "last_update": "2024-10-02",
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      "nct": "NCT04936841",
      "title": "Bempegaldesleukin (NKTR-214) With Radiation and Anti-PD-1 Immunotherapy for Head and Neck Squamous Cell Carcinoma",
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      "nct": "NCT04943445",
      "title": "Study of a Pembrolizumab-based Organ Preservation Strategy for Locally Advanced Larynx Cancers",
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      "nct": "NCT04969861",
      "title": "BEMPEG With Pembrolizumab vs Pembrolizumab Alone in Patients With Metastatic or Recurrent HNSCC (PROPEL-36)",
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      "nct": "NCT04999202",
      "title": "A Study to Learn How Safe the Study Drug BAY 2416964 (AhR Inhibitor) in Combination With the Treatment Pembrolizumab is, How This Combination Affects the Body, the Maximum Amount That Can be Given, How it Moves Into, Through and Out of the Body and Its Action Against Advanced Solid Cancers in Adults",
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     {
      "nct": "NCT05060432",
      "title": "Study of EOS-448 With Standard of Care and/or Investigational Therapies in Participants With Advanced Solid Tumors",
      "status": "UNKNOWN",
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     {
      "nct": "NCT05069935",
      "title": "FT538 in Combination With Monoclonal Antibodies in Advanced Solid Tumors",
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      "last_update": "2023-09-21",
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      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT05077709",
      "title": "IO102-IO103 in Combination With Pembrolizumab as First-line Treatment for Patients With Metastatic NSCLC, SCCHN, or mUBC",
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      "last_update": "2026-04-08",
      "phase": "PHASE2",
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     {
      "nct": "NCT05119296",
      "title": "Phase II Trial of Pembrolizumab in Metastatic or Locally Advanced Anaplastic/Undifferentiated Thyroid Cancer",
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      "last_update": "2026-09-09",
      "phase": "PHASE2",
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     {
      "nct": "NCT05145907",
      "title": "Study to Evaluate Safety and Efficacy of TJ107 Combine With PD-1 in Patients With Solid Tumors",
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     {
      "nct": "NCT05215574",
      "title": "Study of NGM831 as Monotherapy and in Combination With Pembrolizumab or Pembrolizumab and NGM438 in Advanced or Metastatic Solid Tumors",
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     {
      "nct": "NCT05220748",
      "title": "RM-1995 Photoimmunotherapy, as Monotherapy or Combined With Pembrolizumab, in Patients With Advanced CuSCC and HNSCC",
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      "last_update": "2023-04-19",
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      "nct": "NCT05229614",
      "title": "Immunotherapy and Carbon Ion Radiotherapy In Solid Cancers With Stable Disease",
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      "nct": "NCT05234606",
      "title": "A Safety and Preliminary Efficacy Study of SBT6290 Alone and in Combination With PD-(L)1 Inhibitors in Select Advanced Solid Tumors",
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      "nct": "NCT05265013",
      "title": "ASP-1929 Photoimmunotherapy Combined With Pembrolizumab in Patients With Recurrent Head and Neck Cancer, With or Without Metastases",
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      "nct": "NCT05311618",
      "title": "Study of NGM438 as Monotherapy and in Combination With Pembrolizumab in Advanced or Metastatic Solid Tumors",
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      "nct": "NCT05366166",
      "title": "Pembrolizumab Plus Olaparib in LA-HNSCC",
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      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT05393635",
      "title": "ITIL-168 in Advanced Solid Tumors",
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      "nct": "NCT05438420",
      "title": "Oral Axl/Mer/CSF1R Selective Tyrosine Kinase Inhibitor Q702 in Combination With Pembrolizumab in Patients With Selected Advanced Solid Tumors",
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      "nct": "NCT05523323",
      "title": "A Study of Pembrolizumab (MK-3475) With or Without Lenvatinib (E7080/MK-7902) as First Line (1L) Intervention in a Programmed Cell Death-ligand 1 (PD-L1) Selected Population With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma (R/M HNSCC) (MK-7902-010/LEAP-010)-China Extension",
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      "nct": "NCT05576077",
      "title": "A Study of TBio-4101 (TIL) and Pembrolizumab in Patients With Advanced Solid Tumors",
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     {
      "nct": "NCT05581004",
      "title": "A Study to Evaluate the Safety, Pharmacokinetics, and Activity of Enzelkitug as a Single Agent and in Combination With Checkpoint Inhibitor in Participants With Locally Advanced or Metastatic Solid Tumors",
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      "nct": "NCT05585034",
      "title": "Phase 1, First-in-human, Dose-finding and Expansion Study to Evaluate XmAb\u00ae808 in Combination With Pembrolizumab in Advanced Solid Tumors",
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      "nct": "NCT05597839",
      "title": "Study of DF9001 in Patients With Advanced Solid Tumors",
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     {
      "nct": "NCT05620134",
      "title": "Study of JK08 in Patients with Unresectable Locally Advanced or Metastatic Cancer",
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     {
      "nct": "NCT05655663",
      "title": "Evaluation of Vascular Toxicity of Immune Checkpoint Inhibitors in Patients Head and Neck or Lung Cancer",
      "status": "UNKNOWN",
      "last_update": "2022-12-19",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT05704985",
      "title": "Evaluating Safety and Biomarkers Using DK210 (EGFR) for Locally Advanced or Metastatic EGFR+ Tumors",
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      "phase": "PHASE1",
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      "nct": "NCT05708950",
      "title": "A Clinical Trial of KVA12123 [TBS-2025] Treatment Alone and in Combination With Pembrolizumab In Advanced Solid Tumors (VISTA-101)",
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      "nct": "NCT05980598",
      "title": "TransCon (TC) TLR7/8 Agonist, TC IL-2 \u03b2/\u03b3, Pembrolizumab Prior to Surgery for Advanced Head and Neck Squamous Cell Carcinoma",
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     {
      "nct": "NCT06022757",
      "title": "Study of XNW5004 Tablet in Combination With KEYTRUDA\u00ae (Pembrolizumab) in Subjects With Advanced Solid Tumors Who Failed Standard Treatments (KEYNOTE F19)",
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     {
      "nct": "NCT06046482",
      "title": "Phase II Trial of Magrolimab and Cetuximab With Pembrolizumab or Docetaxel for Recurrent/Metastatic Head Neck Squamous Cell Carcinoma",
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      "last_update": "2025-10-22",
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     {
      "nct": "NCT06082167",
      "title": "Study of Zanzalintinib (XL092) + Pembrolizumab vs Pembrolizumab in Subjects With PD-L1 Positive Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma",
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      "nct": "NCT06308913",
      "title": "Pembrolizumab, INCB081776, and Radiation Therapy for Head and Neck Squamous Cell Carcinoma",
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      "phase": "EARLY_PHASE1",
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      "nct": "NCT06513884",
      "title": "A Study of HB-202/HB-201 With Pembrolizumab in Patients With HPV16+ Recurrent/Metastatic Oropharyngeal Cancer",
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      "last_update": "2025-06-22",
      "phase": "PHASE2/PHASE3",
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     {
      "nct": "NCT06557889",
      "title": "Reduction in the Number of Chemotherapy Cycles in Combination With Pembrolizumab in First-line Treatment of PD-L1-positive Recurrent or Metastatic Head and Neck Squamous Cell Carcinomas",
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     {
      "nct": "NCT06676293",
      "title": "Compassionate Use of Asparaginase and Pembrolizumab Combination Theaapy for Nasopharyngeal Carcinoma",
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      "last_update": "2024-11-07",
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      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06682806",
      "title": "A Study of PRT3789 in Combination With Pembrolizumab in Patients With Advanced or Metastatic Solid Tumors With a SMARCA4 Mutation",
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      "phase": "PHASE2",
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      "nct": "NCT06793761",
      "title": "A Phase II Study to Evaluate the Efficacy and Safety of Salvage Preoperative PD-1 Inhibitor Combined with Chemotherapy Neoadjuvant Therapy in Recurrent and Metastatic LPSCC/HPSCC",
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     {
      "nct": "NCT06806852",
      "title": "A Study to Test Whether Treatment With BI 770371 in Combination With Pembrolizumab With or Without Cetuximab Helps People With Head and Neck Cancer Compared With Pembrolizumab Alone",
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      "nct": "NCT06814067",
      "title": "Phase II Multi-centered Study of Perioperative Ivonescimab Versus Pembrolizumab Combined with Standard of Care (SOC) in Patients with Resectable, Locally Advanced Head and Neck Squamous Cell Carcinoma",
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      "title": "A Study of MK-4700 Alone or With Pembrolizumab in Participants With Advanced or Metastatic Solid Tumors (MK-4700-001)",
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      "nct": "NCT07509099",
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      "nct": "NCT07662720",
      "title": "A Phase II Trial for MOR Antagonism With Axelopran to Enhance Immunotherapy in Head and Neck Cancer",
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      "nct": "NCT07744126",
      "title": "A Study to Assess Adverse Events, Change in Disease Activity and Optimal Dose of Intravenous (IV) Telisotuzumab Adizutecan With IV Pembrolizumab for First-Line Treatment of Adult Participants With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma",
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     {
      "nct": "NCT07807345",
      "title": "Phase 1 Study of STRO-006 in Adults With Refractory Solid Tumors That Are Recurrent or Metastatic",
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      "title": "AK129 Combination Therapy for Advanced Solid Tumors",
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      "title": "A Phase II Clinical Trial of Anti-EGFR Antibody-drug Conjugate (ADC) Combined With or Without Immune Checkpoint Inhibitors in the Neoadjuvant Treatment of Resectable Locally Advanced Head and Neck Squamous Cell Carcinoma",
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      "title": "A Study of Penpulimab Combination Therapy in Patients With Advanced Nasopharyngeal Carcinoma",
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      "nct": "NCT04952493",
      "title": "Anlotinib or Penpulimab in Combination With RAI for DTC",
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      "last_update": "2022-01-28",
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      "title": "A Study of Penpulimab (AK105) in the First-line Treatment of Recurrent or Metastatic Nasopharyngeal Carcinoma",
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      "nct": "NCT05193617",
      "title": "Penpulimab Combined With GP \u00b1 Anlotinib as Neoadjuvant Therapy in Locoregionally Advanced Nasopharyngeal Carcinoma",
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      "nct": "NCT05265962",
      "title": "Decitabine Plus Penpulimab as Second-line Therapy for Advanced ESCC Treated With PD-1 Blockade",
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      "title": "Sequential Preoperative Penpulimab Combined With Chemoradiotherapy(CRT) for Locally Advanced Esophageal Squamous Cell Cancer",
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      "title": "A Clinical Trial of TQB2618 Injection Combined With Penpulimab Injection and Chemotherapy Versus Penpulimab Injection Combined With Chemotherapy in First-line Treatment of Relapsed/Metastatic Head and Neck Squamous Cell Carcinoma",
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     {
      "nct": "NCT05807880",
      "title": "Anlotinib, Penpulimab and Capecitabine in Recurrent/Metastatic Nasopharyngeal Carcinoma",
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      "phase": "PHASE2",
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     {
      "nct": "NCT07752394",
      "title": "Penpulimab Combined With Chemotherapy for Patients With Locally Advanced Hypopharyngeal Carcinoma",
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      "nct": "NCT02216916",
      "title": "Phase II Trial of HM781-36B in Patients With Metastatic/Recurrent Head and Neck Squamous Cell Carcinoma (HNSCC) After Failure of or Unfit for Platinum-containing Therapy",
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     {
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      "title": "A Clinical Trial of PF-08046037 Alone or With Sasanlimab in Patients With Advanced or Metastatic Malignancies",
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      "title": "Serplulimab Combined With Nab-paclitaxel and Cisplatin in Neoadjuvant Therapy for Resectable Esophageal Squamous Cell Carcinoma",
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      "title": "A Prospective Randomized Controlled Study of Immune Checkpoint Maintenance Therapy After Radiotherapy and Chemotherapy for Locally Advanced Head and Neck Tumors Based on Peripheral Blood CD8Tex Detection in Peripheral Blood",
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      "title": "Sintilimab After Concurrent Chemoradiotherapy in Elderly Patients With Esophageal Squamous Cell Carcinoma",
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      "title": "A Study of Sintilimab Combined With Chemotherapy for Neoadjuvant Treatment of Esophageal Squamous Cell Carcinoma",
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      "title": "Induction IBI110 and Sintilimab with Chemotherapy in LA HNSCC",
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      "title": "Sintilimab With Chemotherapy Plus PEG-rhG-GSF for Neoadjuvant Treatment of Esophageal Squamous Cell Carcinoma",
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      "nct": "NCT06709417",
      "title": "A Phase II Clinical Study of Sintilimab Combined with Chemotherapy Followed by Concurrent Chemoradiotherapy for Locally Advanced Unresectable Esophageal Squamous Cell Carcinoma (ESCC) (NICE-CS)",
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      "last_update": "2024-11-29",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06718205",
      "title": "Nimotuzumab Combined With Sintilimab and Chemotherapy for Advanced Esophageal Squamous Cell Carcinoma",
      "status": "RECRUITING",
      "last_update": "2024-12-05",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06787911",
      "title": "Donafenib Combined With Anti-PD-1 Antibody for Neoadjuvant Therapy in Locally Advanced Thyroid Cancer",
      "status": "RECRUITING",
      "last_update": "2025-01-22",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07371611",
      "title": "Sintilimab Plus Chemotherapy as Neoadjuvant and Adjuvant Treatment for Locally Advanced Oral Squamous Cell Carcinoma",
      "status": "RECRUITING",
      "last_update": "2026-01-28",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07459296",
      "title": "Becotatug Vedotin Plus Sintilimab in Locoregionally Advanced NPC",
      "status": "RECRUITING",
      "last_update": "2026-03-16",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07581821",
      "title": "Sintilimab Combined With Anlotinib and Taxane-Based Chemotherap for Recurrent/Metastatic Nasopharyngeal Carcinoma",
      "status": "RECRUITING",
      "last_update": "2026-05-12",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07751055",
      "title": "Neoadjuvant Chemoradiotherapy Combined With CTLA-4 Monoclonal Antibody Plus PD-1 Monoclonal Antibody for Locally Advanced Esophageal Cancer",
      "status": "RECRUITING",
      "last_update": "2026-08-07",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03116152",
      "title": "Study of IBI308 With Advanced/Metastatic Esophageal Squamous Cell Carcinoma After Failure of First-line Treatment",
      "status": "COMPLETED",
      "last_update": "2021-02-03",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03619824",
      "title": "PD-1 Blockade Combined With Definitive Chemoradiation in Locoregionally-advanced Nasopharyngeal Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2018-10-09",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03700476",
      "title": "Sintilimab (PD-1 Antibody) and Chemoradiotherapy in Locoregionally-advanced Nasopharyngeal Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2023-03-28",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03748134",
      "title": "Sintilimab or Placebo With Chemotherapy in Esophageal Squamous Cell Carcinoma ( ORIENT-15 )",
      "status": "COMPLETED",
      "last_update": "2023-10-24",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03940001",
      "title": "A Study of Sintilimab Plus Chemoradiation Before Surgery for Esophageal Cancer",
      "status": "UNKNOWN",
      "last_update": "2019-09-09",
      "phase": "EARLY_PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03946969",
      "title": "Sintilimab in Combination With Chemotherapy in Neoadjuvant Treatment of Potentially Resectable Esophageal Cancer",
      "status": "UNKNOWN",
      "last_update": "2022-07-19",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03975270",
      "title": "Sintilimab in Combination With Nab-paclitaxel in Patients With HNSCC (Head and Neck Squamous Cell Carcinoma )",
      "status": "UNKNOWN",
      "last_update": "2019-07-18",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03985046",
      "title": "Sintilimab Plus Chemotherapy Followed by dCRT in Locally Advanced ESCC",
      "status": "COMPLETED",
      "last_update": "2024-11-07",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04065737",
      "title": "Sintilimab to Prevent High-risk Oral Premalignant Lesions Cancerization",
      "status": "UNKNOWN",
      "last_update": "2019-08-22",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04072107",
      "title": "EPstein-barr Virus DNA Response to Systemic Therapy for Treatment Adaptation in High Risk NPC (EP-STAR)",
      "status": "UNKNOWN",
      "last_update": "2023-06-18",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04212598",
      "title": "The Value of Sintilimab Consolidation Therapy After Definitive Concurrent Chemoradiotherapy for Locally Advanced Thoracic Esophageal Cancer",
      "status": "COMPLETED",
      "last_update": "2024-12-10",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04514835",
      "title": "A Phase \u2161 Trials of Sintilimab as Consolidation Therapy After Radical Concurrent Chemoradiotherapy in Locally Advanced Unresectable ESCC",
      "status": "UNKNOWN",
      "last_update": "2021-08-25",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04548440",
      "title": "Efficacy and Safety of Preoperative Sintilimab Plus Nab-paclitaxel and Cisplatin in BR-ESCC Patients",
      "status": "COMPLETED",
      "last_update": "2025-06-12",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04602013",
      "title": "Sintilimab Injection Combined With Concurrent CCRT in Locally Advanced Esophageal Squamous Cell Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2020-10-26",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT04625543",
      "title": "Neoadjuvant Immunotherapy to ESCC",
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      "phase": "PHASE2",
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     },
     {
      "nct": "NCT04718415",
      "title": "Neoadjuvant Sintilimab in Combination With Carboplatin and Nab-paclitaxel in Resectable Oral Cavity or Oropharyngeal Squamous Cell Carcinoma",
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      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT04769076",
      "title": "The Paclitaxel (Albumin-bound) Combined With Cisplatin, PD-1 Inhibitors and IMRT in the Treatment of Nasopharyngeal Carcinoma",
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      "last_update": "2021-02-25",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT04813406",
      "title": "Study of Anlotinib Plus Sintilimab in the Treatment of Advanced Esophageal Squamous Cell Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2021-03-24",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT04872582",
      "title": "Efficacy and Safety of Sintilimab Plus Bevacizumab in Metastatic Nasopharyngeal Carcinoma After Failure of Platinum-based Chemotherapy: An Open-label Phase II Study",
      "status": "UNKNOWN",
      "last_update": "2023-02-23",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT04882462",
      "title": "Sintilimab and Nimotuzumab Combined With Chemotherapy for the Treatment of R/M HNSCC.",
      "status": "UNKNOWN",
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      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT04917770",
      "title": "The Efficacy and Safety of Sintilimab in Combination With Multimodal Radiotherapy in Patients With Recurrent or Metastatic Nasopharyngeal Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2021-06-08",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT05136768",
      "title": "Sintilimab Combined With Chemotherapy and SBRT in Limited Metastatic Head and Neck Squamous Cell Carcinoma (LM-HNSCC)",
      "status": "UNKNOWN",
      "last_update": "2021-11-29",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT05162872",
      "title": "Niraparib And Sintilimab In Recurrent/Metastatic Nasopharyngeal Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2021-12-17",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT05174325",
      "title": "Effectiveness of Neoadjuvant Chemotherapy Combined With PD-1 Monoclonal Antibody in the Treatment of Operable Esophageal Squamous Cell Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2021-12-30",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT05199649",
      "title": "Correlation Between the Efficacy of Neoadjuvant Chemotherapy Combined With Immunotherapy of Operable Thoracic Esophageal Squamous Cell Carcinoma and the Metabolites of Intestinal Flora",
      "status": "UNKNOWN",
      "last_update": "2022-01-20",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT05201859",
      "title": "Adjuvant Sintilimab Plus Capecitabine in Nasopharyngeal Carcinoma",
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      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT05244798",
      "title": "Sintilimab Plus NCT or NCRT Versus NCRT for ESCC",
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      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT05383482",
      "title": "Afuresertib +Sintilimab+Chemotherapy in Patients With Selected Solid Tumors That Resistance to Prior Anti-PD-1/PD-L1",
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      "last_update": "2025-11-17",
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     {
      "nct": "NCT05417139",
      "title": "Sintilimab Combined With Chemotherapy and Radiotherapy in Newly Diagnosed Metastatic Nasopharyngeal Carcinoma: A Multicenter Study",
      "status": "UNKNOWN",
      "last_update": "2022-06-14",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT05476965",
      "title": "Selected De-escalation Radiotherapy for Postoperative Head and Neck Squamous Cell Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2022-07-27",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT05749042",
      "title": "A Study of Concurrent Chemoradiotherapy Based of Cisplatin With or Without Sintilimab as First-line Therapy for Patients With Advanced Oral Cavity Squamous Cell Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2023-03-01",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05777707",
      "title": "Neoadjuvant Therapy of PD-1 Blockade Combined With Chemotherapy for Esophageal Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2023-03-21",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06015035",
      "title": "Sintilimab and Anlotinib Combined With Chemotherapy in Neoadjuvant Treatment of Resectable Esophageal Cancer",
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      "last_update": "2023-08-29",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06078657",
      "title": "IBI110 Combined With Sintilimab in Second-line Advanced or Metastatic Esophageal Squamous Cell Carcinoma(ESCC)",
      "status": "UNKNOWN",
      "last_update": "2023-10-12",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06152978",
      "title": "A Perioperative Sintilimab and Chemotherapy in Esophageal Squamous Cell Carcinoma",
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      "last_update": "2023-12-01",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06161909",
      "title": "Postoperative Immune Maintenance Therapy for Esophageal Squamous Cell Carcinoma After Radical Resection",
      "status": "UNKNOWN",
      "last_update": "2023-12-08",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06184841",
      "title": "HAIC Combined Sintilimab for Liver Metastasis From Esophageal Squamous Cell Carcinoma",
      "status": "COMPLETED",
      "last_update": "2023-12-28",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06364826",
      "title": "Sintilimab Combination Therapy Plus IMRT in Nasopharyngeal Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2024-04-15",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06401447",
      "title": "TPF Concurrent Chemo-radiotherapy Plus Immunotherapy for Local Advanced Esophageal Squamous Cell Carcinoma",
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      "last_update": "2026-04-24",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06403878",
      "title": "Safety and Efficacy of Neoadjuvant Immunochemotherapy in Elderly Patients With Resectable Esophageal Cancer",
      "status": "UNKNOWN",
      "last_update": "2024-05-08",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT06468644",
      "title": "Phase II Study of Different Doses of Radiotherapy Combined With Sintilimab in the Treatment of Locally Advanced Esophageal Squamous Cell Carcinoma",
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      "last_update": "2024-06-21",
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     {
      "nct": "NCT06468670",
      "title": "Short-course Radiotherapy Combined With Sintilimab for Neoadjuvant Treatment of Esophageal Squamous Cell Carcinoma",
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     {
      "nct": "NCT06680115",
      "title": "Neoadjuvant and Adjuvant Sintilimab Combined with Chemoradiotherapy Versus Chemoradiotherapy Alone in Stage TanyN3M0 Nasopharyngeal Carcinoma",
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      "last_update": "2024-11-08",
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     {
      "nct": "NCT06900218",
      "title": "PD-1 Antibody Sintilimab Combined With Capecitabine as Adjuvant Therapy for High-Risk Nasopharyngeal Carcinoma",
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      "title": "Immunochemotherapy \u00b1 Salvage Chemoradiation for Local Recurrence of Esophageal Squamous Cell Carcinoma After Definitive Chemoradiotherapy",
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      "nct": "NCT07306663",
      "title": "Sintilimab Combined With Chemotherapy Induction Therapy Followed by CCRT vs. CCRT for Esophageal Cancer: A Randomized Controlled Phase \u2162 Clinical Study",
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      "title": "A Single-arm, Phase II, Multi-center Clinical Trial of Sintilimab During the Perioperative Period in Patients With Resectable Locally Advanced Head and Neck Squamous Cell Carcinoma",
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     {
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      "title": "Radscopal Radiotherapy Plus Immunotherapy for Chemotherapy-Ineligible Patients With Newly Diagnosed Metastatic Nasopharyngeal Cancer: A Single-Center, Open-Label, Phase II Study",
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     {
      "nct": "NCT07799077",
      "title": "Paclitaxel Polymeric Micelles and Cisplatin Plus Sintilimab as Neoadjuvant Therapy for Resectable Locally Advanced Esophageal Squamous Cell Carcinoma",
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      "title": "Toripalimab Plus Surgery vs Surgery Alone for Resectable Recurrent Nasopharyngeal Carcinoma",
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      "title": "A Study to Evaluate TROP2 ADC LCB84 Single Agent and in Combination With an Anti-PD-1 Ab in Advanced Solid Tumors",
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      "title": "A Study of SI-B003, BL-B01D1+SI-B003 and BL-B01D1+PD-1 Monoclonal Antibody in Patients With Locally Advanced or Metastatic Esophageal Cancer, Gastric Cancer, Colorectal Cancer and Other Gastrointestinal Tumors",
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      "title": "A Study of BL-B01D1+PD-1 Monoclonal Antibody in Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer, Nasopharyngeal Carcinoma and Other Solid Tumors",
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      "title": "EGFR Antibody Combined With PD-1 Inhibitor and Chemotherapy in R/M Nasopharyngeal Carcinoma",
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      "title": "Becotatug Vedotin \u00b1 Anti-PD-1 in Pretreated Advanced ESCC",
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      "title": "A Study of LGK974 in Patients With Malignancies Dependent on Wnt Ligands",
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      "title": "Safety and Efficacy Study of PDR001 in Patients With Recurrent or Metastatic Nasopharyngeal Carcinoma",
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      "title": "Study of the Safety and Efficacy of LHC165 Single Agent and in Combination With PDR001 in Patients With Advanced Malignancies",
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      "title": "PD-1 Blockade Combined With Definitive Chemoradiation in Locoregionally-advanced Nasopharyngeal Carcinoma",
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      "title": "Sym021 in Combination With Either Sym022 or Sym023 or Sym023 and Irinotecan in Patients With Recurrent Advanced Selected Solid Tumor Malignancies",
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      "title": "Efficacy of Tislelizumab and Spartalizumab Across Multiple Cancer-types in Patients with PD1-high MRNA Expressing Tumors",
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      "nct": "NCT04821765",
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      "title": "Tislelizumab Combined With Capecitabine for Nasopharyngeal Carcinoma With Residual EBV DNA After Radiotherapy",
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      "title": "Combination Therapy for PD-1 Resistant Recurrent or Metastatic Nasopharyngeal Carcinoma: A Bayesian Adaptive Phase II Trial",
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      "title": "Phase II Study Evaluating Safety and Efficacy of Tislelizumab for Elderly Patients Unfit for Chemotherapy, With Advanced Esophageal Squamous-cell Carcinoma",
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     {
      "nct": "NCT07317609",
      "title": "Neoadjuvant Immunotherapy Combined With Chemotherapy Sequenced With Endoscopic Resection for Esophageal Cancer (Endosurgery-02)",
      "status": "RECRUITING",
      "last_update": "2026-01-05",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07328854",
      "title": "40.2Gy Versus 49.2Gy Radiotherapy in Low-Risk Target Volume for Chemosensitive Stage II Nasopharyngeal Carcinoma",
      "status": "RECRUITING",
      "last_update": "2026-01-09",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07332247",
      "title": "PD-1 Inhibitor Plus Chemotherapy Followed by Immediate Versus Selective Re-irradiation for Locally Advanced Recurrent NPC",
      "status": "RECRUITING",
      "last_update": "2026-02-04",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07339488",
      "title": "Intestinal Low-Dose Radiotherapy Plus Immunochemotherapy for Conversion of Borderline Resectable/Unresectable Esophageal Squamous Cell Carcinoma",
      "status": "RECRUITING",
      "last_update": "2026-06-18",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07554456",
      "title": "A Study of BL-B01D1 in Combination With Tislelizumab \u00b15-Fluorouracil Versus Platinum-Based Chemotherapy Plus Tislelizumab as First-line Treatment in Patients With Unresectable, Locally Advanced Recurrent or Metastatic Esophageal Squamous Cell Carcinoma(PANKU-Esophagus02)",
      "status": "RECRUITING",
      "last_update": "2026-07-16",
      "phase": "PHASE2/PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07554521",
      "title": "A Study to Evaluate Efficacy and Safety of Tislelizumab Plus Chemotherapy for Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Adenocarcinoma and Esophageal Squamous Cell Carcinoma in Racial and Ethnic Minority Patients in the United States",
      "status": "RECRUITING",
      "last_update": "2026-08-24",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07601737",
      "title": "Nimotuzumab Combined With Immunotherapy and Chemotherapy in the Treatment of Locally Advanced Head and Neck Squamous Cell Carcinoma",
      "status": "RECRUITING",
      "last_update": "2026-07-09",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07700667",
      "title": "SKB500 Combinations in Patients With Esophageal Squamous Cell Carcinoma",
      "status": "RECRUITING",
      "last_update": "2026-08-26",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07762976",
      "title": "Dynamic Risk-adapted EBV-DNA and MRI-guided De-concurrent Chemotherapy in Nasopharyngeal Carcinoma",
      "status": "RECRUITING",
      "last_update": "2026-08-13",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07811752",
      "title": "Sacituzumab Govitecan Combined With Tislelizumab for Locally Advanced/Metastatic Esophageal Cancer",
      "status": "RECRUITING",
      "last_update": "2026-09-10",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03430843",
      "title": "A Study of Tislelizumab (BGB-A317) Versus Chemotherapy as Second Line Treatment in Participants With Advanced Esophageal Squamous Cell Carcinoma",
      "status": "COMPLETED",
      "last_update": "2024-10-26",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03469557",
      "title": "BGB A317 in Combination With Chemotherapy as First-Line Treatment in Adults With Inoperable, Locally Advanced or Metastatic Esophageal, Gastric, or Gastroesophageal Junction Carcinoma",
      "status": "COMPLETED",
      "last_update": "2024-10-23",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03783442",
      "title": "A Study of Tislelizumab (BGB-A317) in Combination With Chemotherapy as First Line Treatment in Participants With Advanced Esophageal Squamous Cell Carcinoma",
      "status": "COMPLETED",
      "last_update": "2025-07-29",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03924986",
      "title": "Tislelizumab Combined With Chemotherapy Versus Chemotherapy Alone in Recurrent or Metastatic Nasopharyngeal Cancer (NPC)",
      "status": "COMPLETED",
      "last_update": "2025-01-31",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03957590",
      "title": "A Study to Investigate Tislelizumab (BGB-A317) Versus Placebo in Combination With Concurrent Chemoradiotherapy in Participants With Localized Esophageal Squamous Cell Carcinoma",
      "status": "COMPLETED",
      "last_update": "2026-04-13",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04215978",
      "title": "Safety and Preliminary Effectiveness of BGB-A445 in Combination With Tislelizumab in Participants With Advanced Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2025-10-03",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04666688",
      "title": "LYT-200 Alone and in Combination With Chemotherapy or Tislelizumab in Patients With Locally Advanced or Metastatic Solid Tumors",
      "status": "COMPLETED",
      "last_update": "2025-02-12",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04732494",
      "title": "Anti-PD-1 Monoclonal Antibody Tislelizumab (BGB-A317) Combined With or Without Anti-TIGIT Monoclonal Antibody Ociperlimab (BGB-A1217) in Participants With Recurrent or Metastatic Esophageal Squamous Cell Carcinoma",
      "status": "COMPLETED",
      "last_update": "2025-01-31",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04776590",
      "title": "Chemoradiotherapy Plus Immunotherapy Followed by Surgery for Esophageal Cancer",
      "status": "UNKNOWN",
      "last_update": "2024-04-12",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04802876",
      "title": "Efficacy of Tislelizumab and Spartalizumab Across Multiple Cancer-types in Patients with PD1-high MRNA Expressing Tumors",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-03-21",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04814069",
      "title": "A Multicenter Phase II Trial of Post-operative Concurrent Chemoradiotherapy Using Weekly Cisplatin With Tislelizumab for Patients With High-risk Head and Neck Squamous Cell Carcinoma\uff1aThe POTENTIAL Study",
      "status": "UNKNOWN",
      "last_update": "2021-03-24",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04821765",
      "title": "Study of PD-1 Antibody Combined With Chemoradiotherapy in Oligometastatic Esophageal Cancer",
      "status": "COMPLETED",
      "last_update": "2025-05-30",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04833257",
      "title": "Neoadjuvant Therapy of GP Chemotherapy Combined With Tislelizumab in Locoregionally Advanced NPC",
      "status": "COMPLETED",
      "last_update": "2025-07-08",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04870905",
      "title": "Tisleilizumab (PD-1 Antibody) and Chemoradiotherapy in Locoregionally-advanced Nasopharyngeal Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2023-03-06",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04921995",
      "title": "Immunotherapy and Chemotherapy in Unresectable Recurrent Loco-regionally Advanced Nasopharyngeal Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2022-04-04",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05152147",
      "title": "A Study of Zanidatamab in Combination With Chemotherapy Plus or Minus Tislelizumab in Patients With HER2-positive Advanced or Metastatic Gastric and Esophageal Cancers",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-09-01",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05211232",
      "title": "Neoadjuvant and Adjuvant Tislelizumab for Nasopharyngeal Carcinoma",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-05-29",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05238883",
      "title": "A Study of HFB200301 as a Single Agent and in Combination With Tislelizumab in Adult Patients With Advanced Solid Tumors",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-11-21",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05245760",
      "title": "ChemoRadiation And Tislelizumab for Esophageal/EGJ Cancer",
      "status": "WITHDRAWN",
      "last_update": "2022-11-08",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05343325",
      "title": "The Efficacy and Safety of Neoadjuvant Low-dose Radiotherapy Combined With Chemoimmunotherapy in Locally Advanced HNSCC",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-09-09",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05394415",
      "title": "Chemoradiation Plus Tislelizumab for Conversion Therapy of Locally Nonresectable ESCC",
      "status": "UNKNOWN",
      "last_update": "2022-05-27",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05448885",
      "title": "Neoadjuvant and Adjuvant Tislelizumab for Nasopharyngeal Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2022-07-08",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05461794",
      "title": "Study To Investigate the Efficacy and Safety of Sitravatinib in Combination With Tislelizumab in Participants With Esophageal Squamous Cell Carcinoma",
      "status": "TERMINATED",
      "last_update": "2025-06-13",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05469061",
      "title": "Tislelizumab in Combination With Chemotherapy for Conversion Therapy of Locally Nonresectable ESCC",
      "status": "UNKNOWN",
      "last_update": "2022-07-21",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05505877",
      "title": "Phase I/IIa Study of BR790 in Combination With Tislelizumab in Adult Subjects With Advanced Solid Tumors",
      "status": "UNKNOWN",
      "last_update": "2022-08-18",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05516589",
      "title": "Neoadjuvant Chemotherapy, Tislelizumab With Afatinib for HNSCC",
      "status": "COMPLETED",
      "last_update": "2025-05-22",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05517330",
      "title": "Neoadjuvant Tislelizumab With Afatinib for Resectable Head and Neck Squamous Cell Carcinoma",
      "status": "COMPLETED",
      "last_update": "2025-07-31",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05520619",
      "title": "Combination of Tislelizumab and Chemoradiotherapy in Esophageal Cancer (EC-CRT-002)",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2024-11-18",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05596890",
      "title": "Patient-reported Outcomes in Preoperative Immunochemotherapy/Radiotherapy-treated Esophageal Cancer Patients",
      "status": "UNKNOWN",
      "last_update": "2022-11-28",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05603065",
      "title": "Tislelizumab With Chemotherapy or Radiation for Neoadjuvant Therapy of Esophageal Squamous Cell Carcinoma (TINES)",
      "status": "UNKNOWN",
      "last_update": "2023-06-29",
      "phase": "PHASE4",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05628610",
      "title": "Tislelizumab Combined With Chemotherapy or Radiotherapy in the Treatment of Advanced or Recurrent Metastatic Elderly Esophageal Cancer",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2024-08-13",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05651022",
      "title": "Study of DECOY20 With or Without Tislelizumab in Patients With Advanced Solid Tumors",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-01-13",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05659186",
      "title": "PD-1 Inhibitor and Anlotinib Combined With Multimodal Radiotherapy in Recurrent or Metastatic Anaplastic Thyroid Cancer",
      "status": "UNKNOWN",
      "last_update": "2022-12-21",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05724329",
      "title": "Neoadjuvant Tislelizumab in Combination With Dasatinib and Quercetin in Resectable HNSCC (COIS-01)",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2024-09-19",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05777707",
      "title": "Neoadjuvant Therapy of PD-1 Blockade Combined With Chemotherapy for Esophageal Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2023-03-21",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05807542",
      "title": "Neoadjuvant Immunotherapy Combined With Chemotherapy in Patients With Locally Advanced ESCC",
      "status": "COMPLETED",
      "last_update": "2024-05-16",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05880082",
      "title": "PPIO-004 Clinical Application of Efficacy Prediction Model Based on Epigenomics Sequencing Technology in Neoadjuvant Immunotherapy for Esophageal Cancer",
      "status": "COMPLETED",
      "last_update": "2025-08-24",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05904496",
      "title": "A Study of BGB-30813 Alone or in Combination With Tislelizumab in Participants With Advanced or Metastatic Solid Tumors",
      "status": "TERMINATED",
      "last_update": "2025-09-16",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05909904",
      "title": "A Study of Tislelizumab in Combination With Investigational Agents in Participants With Head and Neck Squamous Cell Carcinoma",
      "status": "COMPLETED",
      "last_update": "2026-09-01",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06009861",
      "title": "Neoadjuvant Tislelizumab Plus Chemotherapy for Locally Advanced Oral/Oropharyngeal Cancer (NeoSPOT)",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-06-06",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06010303",
      "title": "A Study to Evaluate LBL-007 in Combination With Tislelizumab Plus Chemotherapy in Participants With Unresectable Locally Advanced or Metastatic Esophageal Squamous Cell Carcinoma",
      "status": "COMPLETED",
      "last_update": "2026-05-28",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06130007",
      "title": "A Prospective, Single-arm Phase II Clinical Trial of Tislelizumab Combined With Platinum Doublet Neoadjuvant Therapy to Improve Mandibular Preservation in Resectable Locally Advanced Oral Squamous Cell Carcinoma.",
      "status": "UNKNOWN",
      "last_update": "2023-11-13",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06235918",
      "title": "Neoadjuvant Tislelizumab Plus Chemotherapy for Resectable Locally-advanced Head and Neck Squamous Cell Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2024-02-01",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06259721",
      "title": "Anti-PD1 Monoclonal Antibody Combined With Nimotuzumab and Capecitabine in Patients With First-line Platinum-resistant Recurrent/Metastatic Nasopharyngeal Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2024-03-07",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06303583",
      "title": "Neoadjuvant Chemoradiotherapy Followed by Sequential Immunotherapy for Thoracic Esophageal Squamous Cell Carcinoma",
      "status": "ENROLLING_BY_INVITATION",
      "last_update": "2024-03-12",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06331845",
      "title": "Stop and go Strategy as First-line Treatment for Widely Metastatic Nasopharyngeal Carcinoma",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2024-03-26",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06366945",
      "title": "Tirelizumab in Combination With Carboplatin and Polymeric Micellar Paclitaxel for Neoadjuvant Therapy in cN+ HNSCC",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2024-04-16",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06469060",
      "title": "Neoadjuvant Immunochemotherapy for Adenocarcinoma of the Esophagogastric Junction",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2024-07-01",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06494189",
      "title": "Low-dose Radiotherapy Plus Tislelizumab in Combination With Afatinib for Neoadjuvant Treatment of Surgically Resectable Head and Neck Squamous Carcinoma",
      "status": "COMPLETED",
      "last_update": "2025-12-29",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06554028",
      "title": "Tislelizumab and Induction Chemotherapy for Larynx Preservation in Resectable Advanced Laryngeal/Hypopharyngeal Cancer",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2024-08-14",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06673693",
      "title": "Tislelizumab Combined With SBRT for the Treatment of Head and Neck Squamous Cell Carcinoma",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-08-07",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06692270",
      "title": "Tislelizumab as Single-Agent Neoadjuvant Immunotherapy in Resectable Esophageal Squamous Cell Carcinoma",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2025-02-28",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06703047",
      "title": "Tislelizumab Combined with Chemotherapy and All Trans Retinoic Acid for Locally Advanced or Metastatic Esophageal Squamous Cell Carcinoma",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2024-11-25",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06728618",
      "title": "Preoperative Tislelizumab -Cetuximab - Chemotherapy Followed by Salvage Surgery and Adjuvant Tislelizumab -Cetuximab for Resectable, Locally Recurrent Oral and Oropharyngeal Squamous Cell Carcinoma",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2024-12-11",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06781112",
      "title": "A Phase II Study of TPF With PD-1 Inhibitor Induction Therapy for Locally Advanced Nasopharyngeal Carcinoma",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2025-01-17",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06804850",
      "title": "Neoadjuvant Radiotherapy Plus Targeted Therapy and Immunotherapy vs. Targeted Therapy Plus Immunotherapy in Resectable HNSCC",
      "status": "WITHDRAWN",
      "last_update": "2025-11-19",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06914011",
      "title": "Circulating Tumor DNA MRD-Guided Adjuvant Therapy for Curatively Resected Locally Advanced Esophageal Squamous Cell Carcinoma",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2026-06-02",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06914687",
      "title": "Efficacy of Tirellizumab Combined With Oral, Intravenous and Abdominal Chemotherapy in Peritoneal Metastatic Gastric/Gastroesophageal Junction Adenocarcinoma",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-07-28",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06957938",
      "title": "Comparing Neoadjuvant Chemotherapy Combined With PD-1 Inhibitor Versus Neoadjuvant Chemotherapy in Locally Advanced Laryngeal and Hypopharyngeal Carcinoma",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2025-05-08",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06965829",
      "title": "The Effect of Neoadjuvant Chemoimmnotherapy Combined With Node Sparing Radiotherapy for cT3N+ EC",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2025-05-11",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06990178",
      "title": "Adaptive Neoadjuvant Therapy for Esophageal Cancer",
      "status": "ENROLLING_BY_INVITATION",
      "last_update": "2025-05-25",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07010120",
      "title": "A Clinical Trial of Neoadjuvant Targeted Therapy, Immunotherapy, and Lysogenic HSV-Based Virotherapy in Resectable Head and Neck Squamous Cell Carcinoma",
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      "title": "Clinical Study of Mitoxantrone Hydrochloride Liposome Combined with PD-1 Blockade in Recurrent or Metastatic NPC",
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      "title": "Nimotuzumab Combined With TGP as First-line Therapy in Patients With Recurrent/Metastatic Nasopharyngeal Carcinoma",
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      "phase": "PHASE2",
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      "title": "Gemcitabine + Docetaxel + Toripalimab Induction in Epstein-Barr Virus (EBV) Associated Nasopharyngeal Carcinoma(NPC)",
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      "title": "A Study of CHS-114 (Tagmokitug) in Combination With Toripalimab and/or Other Treatments in Participants With Advanced Solid Tumors",
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      "title": "Under Whole-course of Immunotherapy, Gradient Fractionated RT with CCT Versus CFRT with CCT for LANPC Who Achieved PR Post Induction Chemotherapy.",
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      "title": "A Phase II Study of Toripalimab Combined With Sequential Neoadjuvant Chemoradiotherapy in Patients With Esophageal Squamous Cell Carcinoma",
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      "nct": "NCT06912074",
      "title": "Hypofractionated vs. Conventional Chemoradiotherapy After Induction Chemo-immunotherapy for Unresectable Esophageal Squamous Cell Carcinoma",
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      "phase": "PHASE2",
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      "nct": "NCT06912711",
      "title": "TN Induction and Adjuvant Therapy for Resectable Local Recurrent Nasopharyngeal Carcinoma",
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      "phase": "PHASE2",
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      "nct": "NCT06940180",
      "title": "Toripalimab With Chemotherapy for Sinus Cancer",
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      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT07070479",
      "title": "Combination Therapy for PD-1 Resistant Recurrent or Metastatic Nasopharyngeal Carcinoma: A Bayesian Adaptive Phase II Trial",
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      "last_update": "2025-09-18",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT07086469",
      "title": "Surufatinib in Combination With Neoadjuvant Chemo-immunotherapy and Concurrent Chemoradiotherapy for Patients With Unresectable Locally Advanced Esophageal Squamous Cell Carcinoma",
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      "last_update": "2025-11-17",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT07088211",
      "title": "Sacituzumab Tirumotecan and Toripalimab in the First-line Treatment of HNSCC",
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      "last_update": "2026-06-18",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT07177794",
      "title": "Consolidation of Toripalimab and Capecitabine After Chemoradiotherapy in ESCC",
      "status": "RECRUITING",
      "last_update": "2026-04-21",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT07209189",
      "title": "Neoadjuvant Chemotherapy and Programmed Cell Death Protein 1(PD-1) Inhibition for Head and Neck Cancer Treatment De-escalation (NeoScorch HN)",
      "status": "RECRUITING",
      "last_update": "2026-04-23",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT07214987",
      "title": "PDT For Induction Therapy For Head And Neck Cancer",
      "status": "RECRUITING",
      "last_update": "2026-07-14",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT07258979",
      "title": "A Study of YL201 in Combination With Toripalimab and With or Without Cisplatin in Nasopharyngeal Carcinoma.",
      "status": "RECRUITING",
      "last_update": "2025-12-02",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT07290621",
      "title": "Toripalimab in Combination With Standard Treatment for Human Papillomavirus (HPV) Positive Throat Cancer",
      "status": "RECRUITING",
      "last_update": "2026-02-06",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07325539",
      "title": "LDRT Combined With Toripalimab and Chemotherapy for Recurrent/Metastatic NPC",
      "status": "RECRUITING",
      "last_update": "2026-05-22",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT07328841",
      "title": "Reduced-dose Versus Conventional-dose Intensity-modulated Radiation Therapy for Locally Advanced Nasopharyngeal Carcinoma With Remission After Induction Chemotherapy and Immunotherapy",
      "status": "RECRUITING",
      "last_update": "2026-01-09",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT07332247",
      "title": "PD-1 Inhibitor Plus Chemotherapy Followed by Immediate Versus Selective Re-irradiation for Locally Advanced Recurrent NPC",
      "status": "RECRUITING",
      "last_update": "2026-02-04",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07340515",
      "title": "Proton vs Photon IMRT in Locally Advanced Nasopharyngeal Carcinoma: A Phase III Trial",
      "status": "RECRUITING",
      "last_update": "2026-01-14",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
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     {
      "nct": "NCT07353723",
      "title": "Nimotuzumab Combined With Toripalimab and Chemotherapy for Locally Advanced Tonsillar Cancer",
      "status": "RECRUITING",
      "last_update": "2026-01-20",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07362979",
      "title": "Toripalimab Combined With Different Platinum-Based Induction Chemotherapy Regimens for Locally Advanced Nasopharyngeal Carcinoma",
      "status": "RECRUITING",
      "last_update": "2026-03-17",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07423078",
      "title": "Window of Opportunity in Preserving Laryngeal Function Trial",
      "status": "RECRUITING",
      "last_update": "2026-04-13",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07481058",
      "title": "KC1036 in Combination With PD-1 Antibody and Platinum-based Chemotherapy for First-line Advanced Esophageal Cancer",
      "status": "RECRUITING",
      "last_update": "2026-03-20",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07625423",
      "title": "Intratumoral Injection of Recombinant Human Endostatin Adenovirus (EDS01) for the Treatment of Recurrent or Metastatic Head and Neck Tumors",
      "status": "RECRUITING",
      "last_update": "2026-09-02",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07629817",
      "title": "Surgery vs. Radical Chemoradiotherapy for Esophageal SCC After Neoadjuvant Immunochemotherapy",
      "status": "RECRUITING",
      "last_update": "2026-07-31",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT07706985",
      "title": "Efficacy and Safety of TPC Induction Chemotherapy Combined With Nimotuzumab and Toripalimab \"Immune Sandwich\" Regimen Versus Full-Course Immunotherapy for Locally Advanced Nasopharyngeal Carcinoma",
      "status": "RECRUITING",
      "last_update": "2026-07-16",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT02915432",
      "title": "The Study to Evaluate Toripalimab (JS001) in Patients With Advanced GC, ESCC, NPC, HNSCC",
      "status": "UNKNOWN",
      "last_update": "2021-12-13",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03474640",
      "title": "Safety, Tolerability and Pharmacokinetics of an Anti-PD-1 Monoclonal Antibody in Subjects With Advanced Malignancies",
      "status": "COMPLETED",
      "last_update": "2024-11-22",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03854838",
      "title": "IMRT Combined With Toripalimab in Unresectable Locally Recurrent Nasopharyngeal Carcinoma.",
      "status": "UNKNOWN",
      "last_update": "2022-04-29",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03925090",
      "title": "Phase II Trial of Neoadjuvant and Adjuvant Anti-PD-1 Antibody Toripalimab Combined With CCRT in NPC Patients",
      "status": "UNKNOWN",
      "last_update": "2023-07-03",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03930498",
      "title": "Programmed Death-1 (PD-1) Antibody Combined With Chemoradiotherapy in High-risk Recurrent Nasopharyngeal Carcinoma",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-05-11",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04005170",
      "title": "Combination of Toripalimab and Chemoradiotherapy in Esophageal Cancer",
      "status": "COMPLETED",
      "last_update": "2022-08-23",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04006041",
      "title": "Combination of Toripalimab and Neoadjuvant Chemoradiotherapy in Esophageal Cancer",
      "status": "UNKNOWN",
      "last_update": "2019-12-26",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04073784",
      "title": "Gemcitabine Combined With Apatinib and Toripalimab in Recurrent or Metastatic Nasopharyngeal Carcinoma.",
      "status": "UNKNOWN",
      "last_update": "2022-04-26",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04084158",
      "title": "A Study of Toripalimab Combined With Concurrent Chemoradiotherapy for Locally Advanced Esophageal Squamous Cell Carcinoma.",
      "status": "SUSPENDED",
      "last_update": "2021-02-23",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04126460",
      "title": "High-risk Recurrent or Second Primary HNSCC With PD-1 Antibody Adjuvant After Salvage Surgery(RePASS)",
      "status": "UNKNOWN",
      "last_update": "2019-10-15",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04164238",
      "title": "Neoadjuvant Anti-PD-1 Antibody (Toripalimab) or Combined With Chemotherapy in HNSCC Patients",
      "status": "UNKNOWN",
      "last_update": "2019-11-15",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04177797",
      "title": "Toripalimab With Neoadjuvant Chemotherapy for Locally Advanced Esophageal Squamous Cell Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2022-02-09",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04177875",
      "title": "Neoadjuvant Chemoradiotherapy Combined With PD-1 Antibody in Locally Advanced Esophageal Cancer",
      "status": "UNKNOWN",
      "last_update": "2019-11-26",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04229849",
      "title": "Anrotenib Plus Toripalimab Versus Toripalimab in Patients With Advanced Esophageal Squamous Cell Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2020-01-18",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04296747",
      "title": "Toripalimab in Combination With Chemotherapy as Induced Chemotherapy for Localized Hypopharyngeal Cancer",
      "status": "UNKNOWN",
      "last_update": "2020-03-05",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04398056",
      "title": "Chemotherapy Plus Subsequent Loco-regional Radiotherapy Combined With Toripalimab in the De Novo Metastatic Nasopharyngeal Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2022-07-06",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04405622",
      "title": "Toripalimab and Gemcitabine in Recurrent or Metastatic Nasopharyngeal Carcinoma.",
      "status": "UNKNOWN",
      "last_update": "2023-02-06",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04446663",
      "title": "Toripalimab Combined With Chemoradiotherapy in Patients With Locoregionally-advanced Nasopharyngeal Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2020-06-25",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04447326",
      "title": "Toripalimab, Endostar Combined With Radiotherapy and Chemotherapy for Nasopharyngeal Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2020-06-25",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04473716",
      "title": "Neoadjuvant Toripalimab and Paclitaxel/Cisplatin on Pathological Response in Oral Squamous Cell Carcinoma Patients",
      "status": "COMPLETED",
      "last_update": "2023-11-22",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04517214",
      "title": "Comparing Chemotherapy With/Without Toripalimab For Primary Metastatic Nasopharyngeal Carcinoma",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-04-02",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04523883",
      "title": "Concurrent Immunotherapy With Postoperative Radiotherapy in Intermediate/High Risk HNSCC Patients Unfit for Cisplatin: The IMPORT Study (IMPORT)",
      "status": "UNKNOWN",
      "last_update": "2021-04-15",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04524884",
      "title": "Toripalimab Combined With Surufatinib for Locally Advanced Thyroid Cancer: a Phase II Study",
      "status": "UNKNOWN",
      "last_update": "2020-08-24",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04557020",
      "title": "Adding PD-1 Inhibitor to Neoadjuvant and Adjuvant for NPC",
      "status": "UNKNOWN",
      "last_update": "2024-05-01",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04624308",
      "title": "Toripalimab Plus TPF Chemotherapy and Radiotherapy for LA-HPSCC",
      "status": "UNKNOWN",
      "last_update": "2020-11-10",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04644250",
      "title": "Combination of Toripalimab and Neoadjuvant Chemoradiotherapy for Locally Advanced Esophageal Squamous Cell Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2020-11-25",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04804696",
      "title": "Toripalimab with Paclitaxel and Cisplatin As Neoadjuvant Treatment for Esophageal Squamous Cell Carcinoma",
      "status": "TERMINATED",
      "last_update": "2025-02-21",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04844385",
      "title": "Toripalimab Plus Neoadjuvant Chemotherapy Combined With Chemoradiotherapy for Locally Advanced Unresectable Esophageal Squamous Cell Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2024-02-09",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04856631",
      "title": "A Study of Toripalimab Injection (JS001) + Cetuximab in Treatment of Advanced Head and Neck Squamous Cell Cancer",
      "status": "COMPLETED",
      "last_update": "2026-08-04",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04867330",
      "title": "Toripalimab Based Induction Chemotherapy Followed by De-escalation Protocols in HPV-related OPSCC",
      "status": "UNKNOWN",
      "last_update": "2021-04-30",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04880811",
      "title": "Afatinib Plus Toripalimab in Previously Treated ESCC With EGFR Overexpression or EGFR Amplification",
      "status": "UNKNOWN",
      "last_update": "2021-07-13",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04907370",
      "title": "PD-1 Blockade Combined With De-intensified Chemoradiotherapy Sparing Concurrent Cisplatin in Nasopharyngeal Carcinoma",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-07-16",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04947241",
      "title": "Toripalimab Combined With Gemcitabine and Cisplatin Treating Resectable Locally Advanced HNSCC",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-09-09",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04955886",
      "title": "Surufatinib Combined With Toripalimab in Recurrent or Metastatic Nasopharyngeal Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2021-07-09",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04992988",
      "title": "Concurrent Chemoradiotherapy With Toripalimab for Local-regional Recurrent Nasopharyngeal Carcinoma: a Prospective, Single-arm, Phase II Trial",
      "status": "UNKNOWN",
      "last_update": "2021-08-20",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04995120",
      "title": "Induction Chemotherapy and Toripalimab for Larynx Preservation in Resectable Laryngeal/Hypopharyngeal Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2022-01-18",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04996758",
      "title": "Toripalimab and Anlotinib Combination Treatment in Patients With Recurrent or Metastatic Nasopharyngeal Carcinoma After Failure of at Least One Line of Platinum-Based Chemotherapy (TORAL)",
      "status": "COMPLETED",
      "last_update": "2024-12-12",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05163483",
      "title": "Tucidinostat Plus PD-1 Inhibitor and Bevacizumab for Advanced Esophagus Cancer, AEG, Gastric Cancer",
      "status": "UNKNOWN",
      "last_update": "2023-03-06",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05229315",
      "title": "PD-1 Combined With Intensity Modulated Radiation Therapy in the Treatment of Intermediate-risk Nasopharyngeal Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2023-04-13",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05341193",
      "title": "PD-1 Blockade and Bevacizumab Replace Cisplatin in Locoregionally Advanced Nasopharyngeal Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2022-04-22",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05420597",
      "title": "Induction Chemotherapy and Toripalimab Followed by Radiotherapy in Unresectable Laryngeal/Hypopharyngeal Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2022-06-15",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05424432",
      "title": "Short Course Neoadjuvant Chemo-radiotherapy Plus Toripalimab for Locally Advanced Resectble Squamous Cell Carcinoma of Esophagus",
      "status": "UNKNOWN",
      "last_update": "2022-06-27",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05427396",
      "title": "A Phase I Clinical Study of Recombinant Humanized Anti-BTLA Monoclonal Antibody (JS004) Injection Combined With Toripalimab Injection in Patients With Advanced Solid Tumors",
      "status": "TERMINATED",
      "last_update": "2025-12-03",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05484375",
      "title": "Capecitabine Plus Toripalimab Maintenance Therapy in Metastatic Nasopharyngeal Carcinoma After First-line Treatment",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2022-08-02",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05522985",
      "title": "Toripalimab-based Neoadjuvant Therapy in LA-HNSCC",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-07-17",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05635643",
      "title": "Study of CHS-114 in Participants With Advanced Solid Tumors",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-08-12",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05773079",
      "title": "Toripalimab Maintenance for Locally Advanced Head and Neck Squamous Cell Carcinoma",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2024-04-01",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05777707",
      "title": "Neoadjuvant Therapy of PD-1 Blockade Combined With Chemotherapy for Esophageal Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2023-03-21",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05791136",
      "title": "Immunotherapy After Radiotherapy in Elderly ESCC",
      "status": "UNKNOWN",
      "last_update": "2023-03-30",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05803915",
      "title": "Neoadjuvant Toripalimab Plus Nimotuzumab in Oral Squamous Cell Carcinoma Prior to Radical Therapy",
      "status": "UNKNOWN",
      "last_update": "2023-04-07",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05813626",
      "title": "Neoadjuvant Chemotherapy Plus Toripalimab in Patients With Locoregionally Advanced Nasopharyngeal Carcinoma",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-07-10",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05817201",
      "title": "Toripalimab Plus Radiotherapy for Elderly Esophageal Cancer Patients Treated With Non-chemotherapy Strategy",
      "status": "UNKNOWN",
      "last_update": "2023-04-18",
      "phase": "PHASE2/PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05860335",
      "title": "Efficacy and Safety of Toripalimab Combined With AP-induced Chemotherapy Followed in Non-metastatic IVB Hypopharyngeal Cancer",
      "status": "UNKNOWN",
      "last_update": "2024-02-20",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05869227",
      "title": "Maintenance Therapy With Toripalimab Combined With Capecitabine/Placebo for Recurrent and Metastatic Nasopharyngeal Carcinoma",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2024-12-30",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05955105",
      "title": "A Study of ILB2109 and Toripalimab in Patients With Advanced Solid Malignancies",
      "status": "UNKNOWN",
      "last_update": "2024-05-21",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05993858",
      "title": "Neoadjuvant PD-1 Inhibitor Combined With Cetuximab in Operable Locally Advanced HNSCC",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2023-08-15",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05996484",
      "title": "Neoadjuvant Therapy of Anlotinib Combined With Toripalimab and Chemotherapy for Resectable Esophageal Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2023-08-21",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06020885",
      "title": "Fraction Dose Escalation of Split-course Hypofractionated Concurrent Chemoradiotherapy Following Induction Chemo-immunotherapy in Unresectable Locally Advanced Esophageal Squamous Carcinoma: a Phase I Study.",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-07-21",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06081582",
      "title": "Toripalimab in Combined With Cetuximab\uff0cChemotherapy for Conversion Therapy of Locally Nonresectable OCSCC",
      "status": "UNKNOWN",
      "last_update": "2023-10-13",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06156891",
      "title": "PD-1 Inhibitor Based Induction Chemotherapy Followed by De-escalation Protocols in OPSCC",
      "status": "UNKNOWN",
      "last_update": "2023-12-05",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06259721",
      "title": "Anti-PD1 Monoclonal Antibody Combined With Nimotuzumab and Capecitabine in Patients With First-line Platinum-resistant Recurrent/Metastatic Nasopharyngeal Carcinoma",
      "status": "UNKNOWN",
      "last_update": "2024-03-07",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06281886",
      "title": "Induction Immuno-chemotherapy and Concurrent Chemoradiotherapy With or Without Apatinib in Unresectable, Locally Advanced Esophageal Squamous Cell Carcinoma",
      "status": "COMPLETED",
      "last_update": "2026-08-03",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06378177",
      "title": "A Study of LVGN6051 Combination Therapy in Patient With Head and Neck Squamous Cell Carcinoma (HNSCC)",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-05-19",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06588335",
      "title": "BTLA Inhibitor (JS004) Combined with Toripalimab and Chemotherapy in the Perioperative Treatment of Resectable Locally Advanced Thoracic Esophageal Squamous Cell Carcinoma",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2024-09-19",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06605131",
      "title": "GP Combined with Toripalimab Versus GP Induction Chemotherapy for Advanced Childhood Nasopharyngeal Carcinoma",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2025-03-20",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06647563",
      "title": "Neoadjuvant Toripalimab + Chemotherapy \u00b1 Cetuximab in Locally Advanced Head and Neck Squamous Cell Carcinoma (Neo-ICT)",
      "status": "NOT_YET_RECRUITING",
      "last_update": "2024-10-18",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06712888",
      "title": "Toripalimab vs. Placebo Wtih GP Induction Chemotherapy in Locoregionally Advanced Nasopharyngeal Carcinoma",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2026-08-13",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06762158",
      "title": "NCRT Combined With Sequential Perioperative PD-1 Inhibitor for LAESCC",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-01-07",
      "phase": "NA",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT06861712",
      "title": "Chemoimmunotherapy With or Without SBRT Before Surgery for Locally Advanced Oral and Oropharyngeal Cancer",
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      "title": "Toripalimab Adjuvant Therapy in Subjects With Resected Esophageal Squamous Cell Carcinoma Who Achieved Pathological Complete Response (pCR)",
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      "title": "Radiotherapy Omitting Prophylactic Neck Irradiation With Neoadjuvant and Adjuvant Toripalimab in Nasopharyngeal Carcinoma",
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     {
      "nct": "NCT07136519",
      "title": "Toripalimab, Induction Chemotherapy, Radiation Therapy With Omega-3 for Locally Advanced Nasopharyngeal Carcinoma",
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      "last_update": "2025-08-22",
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      "title": "Neoadjuvant Immunochemotherapy vs Chemoradiotherapy in ESCC",
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      "title": "Stratified Treatment in Unresectable Locally Advanced ESCC Without Progression After Chemoimmunotherapy Induction Plus CCRT: Toripalimab Consolidation vs observation--a Prospective, Randomized, Controlled Phase III Multicenter Study",
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      "title": "A Phase II Study of Toripalimab Plus Chemotherapy and Low-Dose Radiotherapy for Neoadjuvant Therapy-Refractory Esophageal Squamous Cell Carcinoma",
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      "title": "Chidamide in Combination With Toripalimab and Anlotinib in Recurrent/Metastatic Nasopharyngeal Carcinoma.",
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     {
      "nct": "NCT07540390",
      "title": "GAPP Induction and Concurrent Chemoradiotherapy for High-risk Locoregionally Advanced NPC.",
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     {
      "nct": "NCT07555860",
      "title": "Becotatug Vedotin Plus PD-1 Monoclonal Antibody and Radiotherapy for Unresectable Locally Recurrent Nasopharyngeal Carcinoma",
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     {
      "nct": "NCT07653451",
      "title": "Precision Medicine for Immunotherapy-Resistant Advanced Esophageal Cancer",
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      "nct": "NCT07677475",
      "title": "MRG003 Plus Toripalimab Versus Toripalimab as Neoadjuvant Therapy for PD-L1-Positive, Resectable, Locally Advanced Head and Neck Squamous Cell Carcinoma",
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     {
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      "title": "A Multicenter, Prospective, Phase II Study of TROP-2 ADC in Combination With Toripalimab for Resectable Locally Advanced Oral Squamous Cell Carcinoma",
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     {
      "nct": "NCT07796126",
      "title": "Sequential Toripalimab and Paclitaxel in Patients With Head and Neck Squamous Cell Cancer (HNSCC) and Poor Performance Status",
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      "last_update": "2026-08-31",
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      "title": "A Study To Assess ZD6474 (ZACTIMA\u2122) Monotherapy In Locally Advanced or Metastatic Hereditary Medullary Thyroid Cancer",
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      "title": "A Targeted Phase I/II Trial of ZD6474 (Vandetanib; ZACTIMA) Plus the Proteasome Inhibitor, Bortezomib (Velcade ), in Adults With Solid Tumors With a Focus on Hereditary or Sporadic, Locally Advanced or Metastatic Medullary Thyroid Cancer (MTC)",
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      "nct": "NCT00937417",
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      "title": "A Trial of ZD6474, Paclitaxel, Carboplatin, 5-Fluorouracil, and Radiation Therapy Followed by Surgery",
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      "title": "Zalutumumab Pharmacokinetics (PK) in Squamous Cell Carcinoma of the Head and Neck (SCCHN)",
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      "nct": "NCT04892875",
      "title": "A Study of Concurrent Chemoradiation in Combination With or Without PD1 Inhibitor AB122 Adenosine 2a Receptor / Adenosine 2b Receptor Inhibitor AB928 Therapies in Locally Advanced Head and Neck Cancers",
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      "nct": "NCT05891171",
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     {
      "nct": "NCT06107114",
      "title": "Cetuximab+Zimberelimab in Combination With Cisplatin and Nab-paclitaxel in Resctable Head and Neck Squamous Cell Carcinoma",
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      "phase": "PHASE2",
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     {
      "nct": "NCT06727565",
      "title": "Study of Novel Treatment Combination Therapies in Participants With Head and Neck Squamous Cell Carcinoma Regardless of PD-L1 Expression Status; Substudy-01",
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      "last_update": "2026-09-03",
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 }
}