{"disease": {"name": "Hepatocellular carcinoma", "mondo_id": null, "ncit_id": null, "umls_id": null, "oncotree_code": "hcc"}, "updated_at": "2026-09-18", "genome_builds": ["hg19"], "cohort_count": 3, "cohort_count_status": "observed", "cohort_count_unit": "cohorts", "evaluable_patients": null, "evaluable_patients_status": "unknown", "evaluable_patients_unit": "patients", "alteration_types": ["SNV", "small indel", "amplification", "deep deletion"], "genes": [{"gene": "TERT", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 2, "tested": 366, "frequency": 0.55, "cohort_count": 3, "frequency_range": {"min": 0.36, "max": 1.23}, "major_variants": ["V741L (n=1)", "K236T (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lihc_tcga_pan_can_atlas_2018", "source_record_id": "lihc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_inserm_fr_2015", "source_record_id": "hcc_inserm_fr_2015", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_msk_2024", "source_record_id": "hcc_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas), 2/366 patients (0.55%).", "Without the 2 hypermutated patients: 2/364 (0.55%).", "Largest alteration is amplification: 20/367 (5.45%) in the reference cohort's copy-number profile.", "Observed in 3 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "cohort_name": "Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "altered": 2, "tested": 366, "frequency": 0.55, "frequency_excl_hypermutated": 0.55, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "366/372", "coverage_note": null, "source_id": "lihc_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "hcc_inserm_fr_2015", "cohort_name": "Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "altered": 3, "tested": 243, "frequency": 1.23, "frequency_excl_hypermutated": 1.24, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "243/243", "coverage_note": null, "source_id": "hcc_inserm_fr_2015", "is_reference": false}, {"cohort": "hcc_msk_2024", "cohort_name": "Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "altered": 5, "tested": 1370, "frequency": 0.36, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "1370/1370", "coverage_note": null, "source_id": "hcc_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 18.17, "width": 1.0, "reference": 18.17, "scale_max": 30.0}, "headline_alteration": {"kind": "amplification", "altered": 20, "tested": 367, "frequency": 5.45, "is_mutation": false}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "TP53", "alteration_types": ["SNV / small indel", "deep deletion"], "altered": 108, "tested": 366, "frequency": 29.51, "cohort_count": 3, "frequency_range": {"min": 22.22, "max": 34.01}, "major_variants": ["R249S (n=11)", "H193R (n=4)", "X126_splice (n=3)", "V157F (n=3)", "R248Q (n=3)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lihc_tcga_pan_can_atlas_2018", "source_record_id": "lihc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_inserm_fr_2015", "source_record_id": "hcc_inserm_fr_2015", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_msk_2024", "source_record_id": "hcc_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas), 108/366 patients (29.51%).", "Without the 2 hypermutated patients: 106/364 (29.12%).", "Observed in 3 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "cohort_name": "Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "altered": 108, "tested": 366, "frequency": 29.51, "frequency_excl_hypermutated": 29.12, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "366/372", "coverage_note": null, "source_id": "lihc_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "hcc_inserm_fr_2015", "cohort_name": "Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "altered": 54, "tested": 243, "frequency": 22.22, "frequency_excl_hypermutated": 22.31, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "243/243", "coverage_note": null, "source_id": "hcc_inserm_fr_2015", "is_reference": false}, {"cohort": "hcc_msk_2024", "cohort_name": "Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "altered": 466, "tested": 1370, "frequency": 34.01, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "1370/1370", "coverage_note": null, "source_id": "hcc_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 74.07, "width": 25.93, "reference": 98.37, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 108, "tested": 366, "frequency": 29.51, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "CTNNB1", "alteration_types": ["SNV / small indel", "amplification"], "altered": 95, "tested": 366, "frequency": 25.96, "cohort_count": 3, "frequency_range": {"min": 9.64, "max": 36.21}, "major_variants": ["S45P (n=11)", "D32G (n=7)", "K335I (n=6)", "S33C (n=6)", "T41A (n=5)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lihc_tcga_pan_can_atlas_2018", "source_record_id": "lihc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_inserm_fr_2015", "source_record_id": "hcc_inserm_fr_2015", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_msk_2024", "source_record_id": "hcc_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas), 95/366 patients (25.96%).", "Without the 2 hypermutated patients: 94/364 (25.82%).", "Observed in 3 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "cohort_name": "Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "altered": 95, "tested": 366, "frequency": 25.96, "frequency_excl_hypermutated": 25.82, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "366/372", "coverage_note": null, "source_id": "lihc_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "hcc_inserm_fr_2015", "cohort_name": "Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "altered": 88, "tested": 243, "frequency": 36.21, "frequency_excl_hypermutated": 36.36, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "243/243", "coverage_note": null, "source_id": "hcc_inserm_fr_2015", "is_reference": false}, {"cohort": "hcc_msk_2024", "cohort_name": "Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "altered": 132, "tested": 1370, "frequency": 9.64, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "1370/1370", "coverage_note": null, "source_id": "hcc_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 32.13, "width": 67.87, "reference": 86.53, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 95, "tested": 366, "frequency": 25.96, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "AXIN1", "alteration_types": ["SNV / small indel", "deep deletion"], "altered": 25, "tested": 366, "frequency": 6.83, "cohort_count": 3, "frequency_range": {"min": 2.85, "max": 8.64}, "major_variants": ["X340_splice (n=2)", "X293_splice (n=1)", "S225Pfs*17 (n=1)", "L471Pfs*120 (n=1)", "W635* (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lihc_tcga_pan_can_atlas_2018", "source_record_id": "lihc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_inserm_fr_2015", "source_record_id": "hcc_inserm_fr_2015", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_msk_2024", "source_record_id": "hcc_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas), 25/366 patients (6.83%).", "Without the 2 hypermutated patients: 25/364 (6.87%).", "Observed in 3 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "cohort_name": "Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "altered": 25, "tested": 366, "frequency": 6.83, "frequency_excl_hypermutated": 6.87, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "366/372", "coverage_note": null, "source_id": "lihc_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "hcc_inserm_fr_2015", "cohort_name": "Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "altered": 21, "tested": 243, "frequency": 8.64, "frequency_excl_hypermutated": 8.26, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "243/243", "coverage_note": null, "source_id": "hcc_inserm_fr_2015", "is_reference": false}, {"cohort": "hcc_msk_2024", "cohort_name": "Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "altered": 39, "tested": 1370, "frequency": 2.85, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "1370/1370", "coverage_note": null, "source_id": "hcc_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 9.5, "width": 19.3, "reference": 22.77, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 25, "tested": 366, "frequency": 6.83, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "ARID1A", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 28, "tested": 366, "frequency": 7.65, "cohort_count": 3, "frequency_range": {"min": 7.65, "max": 16.5}, "major_variants": ["P728Qfs*87 (n=2)", "Q1142* (n=2)", "A1687Dfs*2 (n=1)", "Q1974Tfs*43 (n=1)", "A2234Gfs*34 (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lihc_tcga_pan_can_atlas_2018", "source_record_id": "lihc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_inserm_fr_2015", "source_record_id": "hcc_inserm_fr_2015", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_msk_2024", "source_record_id": "hcc_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas), 28/366 patients (7.65%).", "Without the 2 hypermutated patients: 28/364 (7.69%).", "Observed in 3 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "cohort_name": "Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "altered": 28, "tested": 366, "frequency": 7.65, "frequency_excl_hypermutated": 7.69, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "366/372", "coverage_note": null, "source_id": "lihc_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "hcc_inserm_fr_2015", "cohort_name": "Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "altered": 24, "tested": 243, "frequency": 9.88, "frequency_excl_hypermutated": 9.5, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "243/243", "coverage_note": null, "source_id": "hcc_inserm_fr_2015", "is_reference": false}, {"cohort": "hcc_msk_2024", "cohort_name": "Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "altered": 226, "tested": 1370, "frequency": 16.5, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "1370/1370", "coverage_note": null, "source_id": "hcc_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 25.5, "width": 29.5, "reference": 25.5, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 28, "tested": 366, "frequency": 7.65, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "MET", "alteration_types": ["SNV / small indel", "amplification"], "altered": 2, "tested": 366, "frequency": 0.55, "cohort_count": 3, "frequency_range": {"min": 0.41, "max": 0.73}, "major_variants": ["H1238L (n=1)", "S22I (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lihc_tcga_pan_can_atlas_2018", "source_record_id": "lihc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_inserm_fr_2015", "source_record_id": "hcc_inserm_fr_2015", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_msk_2024", "source_record_id": "hcc_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas), 2/366 patients (0.55%).", "Without the 2 hypermutated patients: 2/364 (0.55%).", "Largest alteration is amplification: 9/367 (2.45%) in the reference cohort's copy-number profile.", "Observed in 3 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "cohort_name": "Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "altered": 2, "tested": 366, "frequency": 0.55, "frequency_excl_hypermutated": 0.55, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "366/372", "coverage_note": null, "source_id": "lihc_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "hcc_inserm_fr_2015", "cohort_name": "Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "altered": 1, "tested": 243, "frequency": 0.41, "frequency_excl_hypermutated": 0.41, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "243/243", "coverage_note": null, "source_id": "hcc_inserm_fr_2015", "is_reference": false}, {"cohort": "hcc_msk_2024", "cohort_name": "Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "altered": 10, "tested": 1370, "frequency": 0.73, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "1370/1370", "coverage_note": null, "source_id": "hcc_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 8.17, "width": 1.0, "reference": 8.17, "scale_max": 30.0}, "headline_alteration": {"kind": "amplification", "altered": 9, "tested": 367, "frequency": 2.45, "is_mutation": false}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "FGF19", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 0, "tested": 366, "frequency": 0.0, "cohort_count": 2, "frequency_range": {"min": 0.0, "max": 0.41}, "major_variants": [], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lihc_tcga_pan_can_atlas_2018", "source_record_id": "lihc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_inserm_fr_2015", "source_record_id": "hcc_inserm_fr_2015", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_msk_2024", "source_record_id": "hcc_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas), 0/366 patients (0.0%).", "Without the 2 hypermutated patients: 0/364 (0.0%).", "Largest alteration is amplification: 25/367 (6.81%) in the reference cohort's copy-number profile.", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "cohort_name": "Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "altered": 0, "tested": 366, "frequency": 0.0, "frequency_excl_hypermutated": 0.0, "counting_unit": "patients", "status": "not_observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "366/372", "coverage_note": null, "source_id": "lihc_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "hcc_inserm_fr_2015", "cohort_name": "Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "altered": 1, "tested": 243, "frequency": 0.41, "frequency_excl_hypermutated": 0.0, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "243/243", "coverage_note": null, "source_id": "hcc_inserm_fr_2015", "is_reference": false}, {"cohort": "hcc_msk_2024", "cohort_name": "Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "altered": 2, "tested": 1370, "frequency": 0.15, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "1370/1370", "coverage_note": null, "source_id": "hcc_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 22.7, "width": 1.0, "reference": 22.7, "scale_max": 30.0}, "headline_alteration": {"kind": "amplification", "altered": 25, "tested": 367, "frequency": 6.81, "is_mutation": false}, "altered_status": "not_observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "not_observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "FGFR4", "alteration_types": ["SNV / small indel", "amplification"], "altered": 4, "tested": 366, "frequency": 1.09, "cohort_count": 3, "frequency_range": {"min": 0.36, "max": 1.09}, "major_variants": ["R437C (n=1)", "L467M (n=1)", "S377F (n=1)", "R196H (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lihc_tcga_pan_can_atlas_2018", "source_record_id": "lihc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_inserm_fr_2015", "source_record_id": "hcc_inserm_fr_2015", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_msk_2024", "source_record_id": "hcc_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas), 4/366 patients (1.09%).", "Without the 2 hypermutated patients: 3/364 (0.82%).", "Observed in 3 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "cohort_name": "Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "altered": 4, "tested": 366, "frequency": 1.09, "frequency_excl_hypermutated": 0.82, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "366/372", "coverage_note": null, "source_id": "lihc_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "hcc_inserm_fr_2015", "cohort_name": "Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "altered": 1, "tested": 243, "frequency": 0.41, "frequency_excl_hypermutated": 0.41, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "243/243", "coverage_note": null, "source_id": "hcc_inserm_fr_2015", "is_reference": false}, {"cohort": "hcc_msk_2024", "cohort_name": "Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "altered": 5, "tested": 1370, "frequency": 0.36, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "1370/1370", "coverage_note": null, "source_id": "hcc_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 1.2, "width": 2.43, "reference": 3.63, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 4, "tested": 366, "frequency": 1.09, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "KDR", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 7, "tested": 366, "frequency": 1.91, "cohort_count": 3, "frequency_range": {"min": 0.82, "max": 1.91}, "major_variants": ["D433Y (n=1)", "Y1319* (n=1)", "G800R (n=1)", "I456M (n=1)", "A352S (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lihc_tcga_pan_can_atlas_2018", "source_record_id": "lihc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_inserm_fr_2015", "source_record_id": "hcc_inserm_fr_2015", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_msk_2024", "source_record_id": "hcc_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas), 7/366 patients (1.91%).", "Without the 2 hypermutated patients: 6/364 (1.65%).", "Observed in 3 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "cohort_name": "Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "altered": 7, "tested": 366, "frequency": 1.91, "frequency_excl_hypermutated": 1.65, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "366/372", "coverage_note": null, "source_id": "lihc_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "hcc_inserm_fr_2015", "cohort_name": "Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "altered": 2, "tested": 243, "frequency": 0.82, "frequency_excl_hypermutated": 0.41, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "243/243", "coverage_note": null, "source_id": "hcc_inserm_fr_2015", "is_reference": false}, {"cohort": "hcc_msk_2024", "cohort_name": "Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "altered": 18, "tested": 1370, "frequency": 1.31, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "1370/1370", "coverage_note": null, "source_id": "hcc_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 2.73, "width": 3.64, "reference": 6.37, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 7, "tested": 366, "frequency": 1.91, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "VEGFA", "alteration_types": ["SNV / small indel", "amplification"], "altered": 0, "tested": 366, "frequency": 0.0, "cohort_count": 1, "frequency_range": {"min": 0.0, "max": 0.23}, "major_variants": [], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lihc_tcga_pan_can_atlas_2018", "source_record_id": "lihc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_inserm_fr_2015", "source_record_id": "hcc_inserm_fr_2015", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_msk_2024", "source_record_id": "hcc_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas), 0/366 patients (0.0%).", "Without the 2 hypermutated patients: 0/364 (0.0%).", "Largest alteration is amplification: 24/367 (6.54%) in the reference cohort's copy-number profile.", "Observed in 1 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "cohort_name": "Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "altered": 0, "tested": 366, "frequency": 0.0, "frequency_excl_hypermutated": 0.0, "counting_unit": "patients", "status": "not_observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "366/372", "coverage_note": null, "source_id": "lihc_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "hcc_inserm_fr_2015", "cohort_name": "Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "altered": 0, "tested": 243, "frequency": 0.0, "frequency_excl_hypermutated": 0.0, "counting_unit": "patients", "status": "not_observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "243/243", "coverage_note": null, "source_id": "hcc_inserm_fr_2015", "is_reference": false}, {"cohort": "hcc_msk_2024", "cohort_name": "Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "altered": 3, "tested": 1284, "frequency": 0.23, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "1370/1370", "coverage_note": null, "source_id": "hcc_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 21.8, "width": 1.0, "reference": 21.8, "scale_max": 30.0}, "headline_alteration": {"kind": "amplification", "altered": 24, "tested": 367, "frequency": 6.54, "is_mutation": false}, "altered_status": "not_observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "not_observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "GPC3", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 2, "tested": 366, "frequency": 0.55, "cohort_count": 2, "frequency_range": {"min": 0.41, "max": 0.55}, "major_variants": ["K347N (n=1)", "K206N (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lihc_tcga_pan_can_atlas_2018", "source_record_id": "lihc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_inserm_fr_2015", "source_record_id": "hcc_inserm_fr_2015", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_msk_2024", "source_record_id": "hcc_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas), 2/366 patients (0.55%).", "Without the 2 hypermutated patients: 2/364 (0.55%).", "Largest alteration is deep deletion: 7/367 (1.91%) in the reference cohort's copy-number profile.", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "cohort_name": "Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "altered": 2, "tested": 366, "frequency": 0.55, "frequency_excl_hypermutated": 0.55, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "366/372", "coverage_note": null, "source_id": "lihc_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "hcc_inserm_fr_2015", "cohort_name": "Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "altered": 1, "tested": 243, "frequency": 0.41, "frequency_excl_hypermutated": 0.41, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "243/243", "coverage_note": null, "source_id": "hcc_inserm_fr_2015", "is_reference": false}, {"cohort": "hcc_msk_2024", "cohort_name": "Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "1370/1370", "coverage_note": null, "source_id": "hcc_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 6.37, "width": 1.0, "reference": 6.37, "scale_max": 30.0}, "headline_alteration": {"kind": "deep deletion", "altered": 7, "tested": 367, "frequency": 1.91, "is_mutation": false}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "ALB", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 47, "tested": 366, "frequency": 12.84, "cohort_count": 3, "frequency_range": {"min": 8.14, "max": 12.84}, "major_variants": ["X161_splice (n=5)", "X476_splice (n=3)", "V448Cfs*16 (n=2)", "R221Tfs*30 (n=2)", "A374S (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lihc_tcga_pan_can_atlas_2018", "source_record_id": "lihc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_inserm_fr_2015", "source_record_id": "hcc_inserm_fr_2015", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_msk_2024", "source_record_id": "hcc_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas), 47/366 patients (12.84%).", "Without the 2 hypermutated patients: 47/364 (12.91%).", "Observed in 3 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "cohort_name": "Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "altered": 47, "tested": 366, "frequency": 12.84, "frequency_excl_hypermutated": 12.91, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "366/372", "coverage_note": null, "source_id": "lihc_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "hcc_inserm_fr_2015", "cohort_name": "Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "altered": 26, "tested": 243, "frequency": 10.7, "frequency_excl_hypermutated": 10.74, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "243/243", "coverage_note": null, "source_id": "hcc_inserm_fr_2015", "is_reference": false}, {"cohort": "hcc_msk_2024", "cohort_name": "Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "altered": 18, "tested": 221, "frequency": 8.14, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "1370/1370", "coverage_note": null, "source_id": "hcc_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 27.13, "width": 15.67, "reference": 42.8, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 47, "tested": 366, "frequency": 12.84, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "CACNA1E", "alteration_types": ["SNV / small indel", "amplification"], "altered": 28, "tested": 366, "frequency": 7.65, "cohort_count": 2, "frequency_range": {"min": 2.47, "max": 7.65}, "major_variants": ["N255I (n=2)", "N1357S (n=1)", "V1409A (n=1)", "R378H (n=1)", "P2144L (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lihc_tcga_pan_can_atlas_2018", "source_record_id": "lihc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_inserm_fr_2015", "source_record_id": "hcc_inserm_fr_2015", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_msk_2024", "source_record_id": "hcc_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas), 28/366 patients (7.65%).", "Without the 2 hypermutated patients: 26/364 (7.14%).", "Largest alteration is amplification: 29/367 (7.9%) in the reference cohort's copy-number profile.", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "cohort_name": "Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "altered": 28, "tested": 366, "frequency": 7.65, "frequency_excl_hypermutated": 7.14, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "366/372", "coverage_note": null, "source_id": "lihc_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "hcc_inserm_fr_2015", "cohort_name": "Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "altered": 6, "tested": 243, "frequency": 2.47, "frequency_excl_hypermutated": 2.07, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "243/243", "coverage_note": null, "source_id": "hcc_inserm_fr_2015", "is_reference": false}, {"cohort": "hcc_msk_2024", "cohort_name": "Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "1370/1370", "coverage_note": null, "source_id": "hcc_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 26.33, "width": 1.0, "reference": 26.33, "scale_max": 30.0}, "headline_alteration": {"kind": "amplification", "altered": 29, "tested": 367, "frequency": 7.9, "is_mutation": false}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "PRKDC", "alteration_types": ["SNV / small indel", "amplification"], "altered": 22, "tested": 366, "frequency": 6.01, "cohort_count": 2, "frequency_range": {"min": 2.06, "max": 6.01}, "major_variants": ["X270_splice (n=2)", "W601C (n=1)", "R2728L (n=1)", "K1074* (n=1)", "D3756V (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lihc_tcga_pan_can_atlas_2018", "source_record_id": "lihc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_inserm_fr_2015", "source_record_id": "hcc_inserm_fr_2015", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_msk_2024", "source_record_id": "hcc_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas), 22/366 patients (6.01%).", "Without the 2 hypermutated patients: 21/364 (5.77%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "cohort_name": "Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "altered": 22, "tested": 366, "frequency": 6.01, "frequency_excl_hypermutated": 5.77, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "366/372", "coverage_note": null, "source_id": "lihc_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "hcc_inserm_fr_2015", "cohort_name": "Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "altered": 5, "tested": 243, "frequency": 2.06, "frequency_excl_hypermutated": 1.65, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "243/243", "coverage_note": null, "source_id": "hcc_inserm_fr_2015", "is_reference": false}, {"cohort": "hcc_msk_2024", "cohort_name": "Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "1370/1370", "coverage_note": null, "source_id": "hcc_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 6.87, "width": 13.16, "reference": 20.03, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 22, "tested": 366, "frequency": 6.01, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "DOCK2", "alteration_types": ["SNV / small indel", "amplification"], "altered": 22, "tested": 366, "frequency": 6.01, "cohort_count": 2, "frequency_range": {"min": 3.7, "max": 6.01}, "major_variants": ["Y1555* (n=1)", "Y257H (n=1)", "Q996* (n=1)", "R1446W (n=1)", "Q878K (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lihc_tcga_pan_can_atlas_2018", "source_record_id": "lihc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_inserm_fr_2015", "source_record_id": "hcc_inserm_fr_2015", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_msk_2024", "source_record_id": "hcc_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas), 22/366 patients (6.01%).", "Without the 2 hypermutated patients: 20/364 (5.49%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "cohort_name": "Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "altered": 22, "tested": 366, "frequency": 6.01, "frequency_excl_hypermutated": 5.49, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "366/372", "coverage_note": null, "source_id": "lihc_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "hcc_inserm_fr_2015", "cohort_name": "Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "altered": 9, "tested": 243, "frequency": 3.7, "frequency_excl_hypermutated": 3.72, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "243/243", "coverage_note": null, "source_id": "hcc_inserm_fr_2015", "is_reference": false}, {"cohort": "hcc_msk_2024", "cohort_name": "Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "1370/1370", "coverage_note": null, "source_id": "hcc_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 12.33, "width": 7.7, "reference": 20.03, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 22, "tested": 366, "frequency": 6.01, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "WDR87", "alteration_types": ["SNV / small indel", "amplification"], "altered": 20, "tested": 366, "frequency": 5.46, "cohort_count": 2, "frequency_range": {"min": 2.47, "max": 5.46}, "major_variants": ["E1898* (n=2)", "Q1897H (n=2)", "I2076M (n=1)", "R2437Sfs*6 (n=1)", "P2389H (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lihc_tcga_pan_can_atlas_2018", "source_record_id": "lihc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_inserm_fr_2015", "source_record_id": "hcc_inserm_fr_2015", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_msk_2024", "source_record_id": "hcc_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas), 20/366 patients (5.46%).", "Without the 2 hypermutated patients: 19/364 (5.22%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "cohort_name": "Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "altered": 20, "tested": 366, "frequency": 5.46, "frequency_excl_hypermutated": 5.22, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "366/372", "coverage_note": null, "source_id": "lihc_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "hcc_inserm_fr_2015", "cohort_name": "Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "altered": 6, "tested": 243, "frequency": 2.47, "frequency_excl_hypermutated": 2.07, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "243/243", "coverage_note": null, "source_id": "hcc_inserm_fr_2015", "is_reference": false}, {"cohort": "hcc_msk_2024", "cohort_name": "Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "1370/1370", "coverage_note": null, "source_id": "hcc_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 8.23, "width": 9.97, "reference": 18.2, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 20, "tested": 366, "frequency": 5.46, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "SDK1", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 20, "tested": 366, "frequency": 5.46, "cohort_count": 2, "frequency_range": {"min": 3.29, "max": 5.46}, "major_variants": ["G653A (n=1)", "L568F (n=1)", "L1483H (n=1)", "A847G (n=1)", "R168H (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lihc_tcga_pan_can_atlas_2018", "source_record_id": "lihc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_inserm_fr_2015", "source_record_id": "hcc_inserm_fr_2015", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_msk_2024", "source_record_id": "hcc_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas), 20/366 patients (5.46%).", "Without the 2 hypermutated patients: 20/364 (5.49%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "cohort_name": "Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "altered": 20, "tested": 366, "frequency": 5.46, "frequency_excl_hypermutated": 5.49, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "366/372", "coverage_note": null, "source_id": "lihc_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "hcc_inserm_fr_2015", "cohort_name": "Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "altered": 8, "tested": 243, "frequency": 3.29, "frequency_excl_hypermutated": 2.89, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "243/243", "coverage_note": null, "source_id": "hcc_inserm_fr_2015", "is_reference": false}, {"cohort": "hcc_msk_2024", "cohort_name": "Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "1370/1370", "coverage_note": null, "source_id": "hcc_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 10.97, "width": 7.23, "reference": 18.2, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 20, "tested": 366, "frequency": 5.46, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "HERC2", "alteration_types": ["SNV / small indel", "deep deletion"], "altered": 20, "tested": 366, "frequency": 5.46, "cohort_count": 2, "frequency_range": {"min": 2.88, "max": 5.46}, "major_variants": ["G2804C (n=1)", "E3307K (n=1)", "A4155V (n=1)", "K2304* (n=1)", "S2548R (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lihc_tcga_pan_can_atlas_2018", "source_record_id": "lihc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_inserm_fr_2015", "source_record_id": "hcc_inserm_fr_2015", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_msk_2024", "source_record_id": "hcc_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas), 20/366 patients (5.46%).", "Without the 2 hypermutated patients: 20/364 (5.49%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "cohort_name": "Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "altered": 20, "tested": 366, "frequency": 5.46, "frequency_excl_hypermutated": 5.49, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "366/372", "coverage_note": null, "source_id": "lihc_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "hcc_inserm_fr_2015", "cohort_name": "Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "altered": 7, "tested": 243, "frequency": 2.88, "frequency_excl_hypermutated": 2.48, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "243/243", "coverage_note": null, "source_id": "hcc_inserm_fr_2015", "is_reference": false}, {"cohort": "hcc_msk_2024", "cohort_name": "Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "1370/1370", "coverage_note": null, "source_id": "hcc_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 9.6, "width": 8.6, "reference": 18.2, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 20, "tested": 366, "frequency": 5.46, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "FRAS1", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 20, "tested": 366, "frequency": 5.46, "cohort_count": 2, "frequency_range": {"min": 5.35, "max": 5.46}, "major_variants": ["Q1411* (n=1)", "P3679L (n=1)", "E393G (n=1)", "X2344_splice (n=1)", "S3118F (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lihc_tcga_pan_can_atlas_2018", "source_record_id": "lihc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_inserm_fr_2015", "source_record_id": "hcc_inserm_fr_2015", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_msk_2024", "source_record_id": "hcc_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas), 20/366 patients (5.46%).", "Without the 2 hypermutated patients: 19/364 (5.22%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "cohort_name": "Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "altered": 20, "tested": 366, "frequency": 5.46, "frequency_excl_hypermutated": 5.22, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "366/372", "coverage_note": null, "source_id": "lihc_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "hcc_inserm_fr_2015", "cohort_name": "Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "altered": 13, "tested": 243, "frequency": 5.35, "frequency_excl_hypermutated": 4.96, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "243/243", "coverage_note": null, "source_id": "hcc_inserm_fr_2015", "is_reference": false}, {"cohort": "hcc_msk_2024", "cohort_name": "Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "1370/1370", "coverage_note": null, "source_id": "hcc_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 17.83, "width": 1.0, "reference": 18.2, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 20, "tested": 366, "frequency": 5.46, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "BAP1", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 20, "tested": 366, "frequency": 5.46, "cohort_count": 3, "frequency_range": {"min": 1.65, "max": 8.54}, "major_variants": ["W202L (n=1)", "A359Tfs*68 (n=1)", "X662_splice (n=1)", "M115Rfs*9 (n=1)", "P235_R237del (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lihc_tcga_pan_can_atlas_2018", "source_record_id": "lihc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_inserm_fr_2015", "source_record_id": "hcc_inserm_fr_2015", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_msk_2024", "source_record_id": "hcc_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas), 20/366 patients (5.46%).", "Without the 2 hypermutated patients: 20/364 (5.49%).", "Observed in 3 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "cohort_name": "Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "altered": 20, "tested": 366, "frequency": 5.46, "frequency_excl_hypermutated": 5.49, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "366/372", "coverage_note": null, "source_id": "lihc_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "hcc_inserm_fr_2015", "cohort_name": "Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "altered": 4, "tested": 243, "frequency": 1.65, "frequency_excl_hypermutated": 1.65, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "243/243", "coverage_note": null, "source_id": "hcc_inserm_fr_2015", "is_reference": false}, {"cohort": "hcc_msk_2024", "cohort_name": "Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "altered": 117, "tested": 1370, "frequency": 8.54, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "1370/1370", "coverage_note": null, "source_id": "hcc_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 5.5, "width": 22.97, "reference": 18.2, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 20, "tested": 366, "frequency": 5.46, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "RB1", "alteration_types": ["SNV / small indel", "deep deletion"], "altered": 19, "tested": 366, "frequency": 5.19, "cohort_count": 3, "frequency_range": {"min": 3.21, "max": 5.19}, "major_variants": ["N399Kfs*7 (n=2)", "N290Kfs*20 (n=1)", "V759_L769del (n=1)", "I66K (n=1)", "P67A (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lihc_tcga_pan_can_atlas_2018", "source_record_id": "lihc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_inserm_fr_2015", "source_record_id": "hcc_inserm_fr_2015", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_msk_2024", "source_record_id": "hcc_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas), 19/366 patients (5.19%).", "Without the 2 hypermutated patients: 18/364 (4.95%).", "Observed in 3 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "cohort_name": "Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "altered": 19, "tested": 366, "frequency": 5.19, "frequency_excl_hypermutated": 4.95, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "366/372", "coverage_note": null, "source_id": "lihc_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "hcc_inserm_fr_2015", "cohort_name": "Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "altered": 8, "tested": 243, "frequency": 3.29, "frequency_excl_hypermutated": 3.31, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "243/243", "coverage_note": null, "source_id": "hcc_inserm_fr_2015", "is_reference": false}, {"cohort": "hcc_msk_2024", "cohort_name": "Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "altered": 44, "tested": 1370, "frequency": 3.21, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "1370/1370", "coverage_note": null, "source_id": "hcc_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 10.7, "width": 6.6, "reference": 17.3, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 19, "tested": 366, "frequency": 5.19, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "PCDH15", "alteration_types": ["SNV / small indel", "amplification"], "altered": 19, "tested": 366, "frequency": 5.19, "cohort_count": 2, "frequency_range": {"min": 5.19, "max": 6.17}, "major_variants": ["R1514Q (n=1)", "G655* (n=1)", "Q401E (n=1)", "E294* (n=1)", "R683C (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lihc_tcga_pan_can_atlas_2018", "source_record_id": "lihc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_inserm_fr_2015", "source_record_id": "hcc_inserm_fr_2015", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_msk_2024", "source_record_id": "hcc_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas), 19/366 patients (5.19%).", "Without the 2 hypermutated patients: 19/364 (5.22%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "cohort_name": "Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "altered": 19, "tested": 366, "frequency": 5.19, "frequency_excl_hypermutated": 5.22, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "366/372", "coverage_note": null, "source_id": "lihc_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "hcc_inserm_fr_2015", "cohort_name": "Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "altered": 15, "tested": 243, "frequency": 6.17, "frequency_excl_hypermutated": 5.79, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "243/243", "coverage_note": null, "source_id": "hcc_inserm_fr_2015", "is_reference": false}, {"cohort": "hcc_msk_2024", "cohort_name": "Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "1370/1370", "coverage_note": null, "source_id": "hcc_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 17.3, "width": 3.27, "reference": 17.3, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 19, "tested": 366, "frequency": 5.19, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "LRP1", "alteration_types": ["SNV / small indel", "amplification"], "altered": 19, "tested": 366, "frequency": 5.19, "cohort_count": 2, "frequency_range": {"min": 2.47, "max": 5.19}, "major_variants": ["G1431C (n=2)", "T4331S (n=1)", "A1009D (n=1)", "T778Lfs*2 (n=1)", "S1997F (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lihc_tcga_pan_can_atlas_2018", "source_record_id": "lihc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_inserm_fr_2015", "source_record_id": "hcc_inserm_fr_2015", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_msk_2024", "source_record_id": "hcc_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas), 19/366 patients (5.19%).", "Without the 2 hypermutated patients: 18/364 (4.95%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "cohort_name": "Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "altered": 19, "tested": 366, "frequency": 5.19, "frequency_excl_hypermutated": 4.95, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "366/372", "coverage_note": null, "source_id": "lihc_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "hcc_inserm_fr_2015", "cohort_name": "Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "altered": 6, "tested": 243, "frequency": 2.47, "frequency_excl_hypermutated": 2.07, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "243/243", "coverage_note": null, "source_id": "hcc_inserm_fr_2015", "is_reference": false}, {"cohort": "hcc_msk_2024", "cohort_name": "Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "1370/1370", "coverage_note": null, "source_id": "hcc_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 8.23, "width": 9.07, "reference": 17.3, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 19, "tested": 366, "frequency": 5.19, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "KMT2D", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 19, "tested": 366, "frequency": 5.19, "cohort_count": 3, "frequency_range": {"min": 4.67, "max": 5.76}, "major_variants": ["E541K (n=1)", "R3547H (n=1)", "S3Tfs*4 (n=1)", "D3039G (n=1)", "E4418Nfs*14 (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lihc_tcga_pan_can_atlas_2018", "source_record_id": "lihc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_inserm_fr_2015", "source_record_id": "hcc_inserm_fr_2015", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_msk_2024", "source_record_id": "hcc_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas), 19/366 patients (5.19%).", "Without the 2 hypermutated patients: 17/364 (4.67%).", "Observed in 3 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "cohort_name": "Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "altered": 19, "tested": 366, "frequency": 5.19, "frequency_excl_hypermutated": 4.67, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "366/372", "coverage_note": null, "source_id": "lihc_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "hcc_inserm_fr_2015", "cohort_name": "Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "altered": 14, "tested": 243, "frequency": 5.76, "frequency_excl_hypermutated": 5.37, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "243/243", "coverage_note": null, "source_id": "hcc_inserm_fr_2015", "is_reference": false}, {"cohort": "hcc_msk_2024", "cohort_name": "Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "altered": 64, "tested": 1370, "frequency": 4.67, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "1370/1370", "coverage_note": null, "source_id": "hcc_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 15.57, "width": 3.63, "reference": 17.3, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 19, "tested": 366, "frequency": 5.19, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "FREM2", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 19, "tested": 366, "frequency": 5.19, "cohort_count": 2, "frequency_range": {"min": 2.88, "max": 5.19}, "major_variants": ["D1333H (n=2)", "E1192* (n=2)", "G5R (n=1)", "P1903L (n=1)", "E1610Q (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lihc_tcga_pan_can_atlas_2018", "source_record_id": "lihc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_inserm_fr_2015", "source_record_id": "hcc_inserm_fr_2015", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_msk_2024", "source_record_id": "hcc_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas), 19/366 patients (5.19%).", "Without the 2 hypermutated patients: 18/364 (4.95%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "cohort_name": "Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "altered": 19, "tested": 366, "frequency": 5.19, "frequency_excl_hypermutated": 4.95, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "366/372", "coverage_note": null, "source_id": "lihc_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "hcc_inserm_fr_2015", "cohort_name": "Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "altered": 7, "tested": 243, "frequency": 2.88, "frequency_excl_hypermutated": 2.48, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "243/243", "coverage_note": null, "source_id": "hcc_inserm_fr_2015", "is_reference": false}, {"cohort": "hcc_msk_2024", "cohort_name": "Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "1370/1370", "coverage_note": null, "source_id": "hcc_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 9.6, "width": 7.7, "reference": 17.3, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 19, "tested": 366, "frequency": 5.19, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "FASN", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 19, "tested": 366, "frequency": 5.19, "cohort_count": 2, "frequency_range": {"min": 3.7, "max": 5.19}, "major_variants": ["F146S (n=2)", "I1057V (n=1)", "E1136D (n=1)", "G102E (n=1)", "E660* (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lihc_tcga_pan_can_atlas_2018", "source_record_id": "lihc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_inserm_fr_2015", "source_record_id": "hcc_inserm_fr_2015", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_msk_2024", "source_record_id": "hcc_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas), 19/366 patients (5.19%).", "Without the 2 hypermutated patients: 19/364 (5.22%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "cohort_name": "Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "altered": 19, "tested": 366, "frequency": 5.19, "frequency_excl_hypermutated": 5.22, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "366/372", "coverage_note": null, "source_id": "lihc_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "hcc_inserm_fr_2015", "cohort_name": "Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "altered": 9, "tested": 243, "frequency": 3.7, "frequency_excl_hypermutated": 3.31, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "243/243", "coverage_note": null, "source_id": "hcc_inserm_fr_2015", "is_reference": false}, {"cohort": "hcc_msk_2024", "cohort_name": "Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "1370/1370", "coverage_note": null, "source_id": "hcc_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 12.33, "width": 4.97, "reference": 17.3, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 19, "tested": 366, "frequency": 5.19, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "BIRC6", "alteration_types": ["SNV / small indel", "amplification"], "altered": 19, "tested": 366, "frequency": 5.19, "cohort_count": 2, "frequency_range": {"min": 3.7, "max": 5.19}, "major_variants": ["F4598V (n=1)", "V2162A (n=1)", "R3939K (n=1)", "I242* (n=1)", "E550* (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lihc_tcga_pan_can_atlas_2018", "source_record_id": "lihc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_inserm_fr_2015", "source_record_id": "hcc_inserm_fr_2015", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_msk_2024", "source_record_id": "hcc_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas), 19/366 patients (5.19%).", "Without the 2 hypermutated patients: 17/364 (4.67%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "cohort_name": "Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "altered": 19, "tested": 366, "frequency": 5.19, "frequency_excl_hypermutated": 4.67, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "366/372", "coverage_note": null, "source_id": "lihc_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "hcc_inserm_fr_2015", "cohort_name": "Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "altered": 9, "tested": 243, "frequency": 3.7, "frequency_excl_hypermutated": 3.31, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "243/243", "coverage_note": null, "source_id": "hcc_inserm_fr_2015", "is_reference": false}, {"cohort": "hcc_msk_2024", "cohort_name": "Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "1370/1370", "coverage_note": null, "source_id": "hcc_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 12.33, "width": 4.97, "reference": 17.3, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 19, "tested": 366, "frequency": 5.19, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "ARID2", "alteration_types": ["SNV / small indel", "deep deletion", "amplification"], "altered": 19, "tested": 366, "frequency": 5.19, "cohort_count": 3, "frequency_range": {"min": 4.89, "max": 6.17}, "major_variants": ["L370* (n=1)", "P1487Qfs*25 (n=1)", "X1592_splice (n=1)", "N309Y (n=1)", "C1667* (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lihc_tcga_pan_can_atlas_2018", "source_record_id": "lihc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_inserm_fr_2015", "source_record_id": "hcc_inserm_fr_2015", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_msk_2024", "source_record_id": "hcc_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas), 19/366 patients (5.19%).", "Without the 2 hypermutated patients: 19/364 (5.22%).", "Observed in 3 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "cohort_name": "Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "altered": 19, "tested": 366, "frequency": 5.19, "frequency_excl_hypermutated": 5.22, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "366/372", "coverage_note": null, "source_id": "lihc_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "hcc_inserm_fr_2015", "cohort_name": "Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "altered": 15, "tested": 243, "frequency": 6.17, "frequency_excl_hypermutated": 5.79, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "243/243", "coverage_note": null, "source_id": "hcc_inserm_fr_2015", "is_reference": false}, {"cohort": "hcc_msk_2024", "cohort_name": "Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "altered": 67, "tested": 1370, "frequency": 4.89, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "1370/1370", "coverage_note": null, "source_id": "hcc_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 16.3, "width": 4.27, "reference": 17.3, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 19, "tested": 366, "frequency": 5.19, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "UNC80", "alteration_types": ["SNV / small indel", "amplification"], "altered": 18, "tested": 366, "frequency": 4.92, "cohort_count": 2, "frequency_range": {"min": 3.29, "max": 4.92}, "major_variants": ["G1551R (n=1)", "L1568S (n=1)", "S630I (n=1)", "S2414R (n=1)", "H1014L (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lihc_tcga_pan_can_atlas_2018", "source_record_id": "lihc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_inserm_fr_2015", "source_record_id": "hcc_inserm_fr_2015", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_msk_2024", "source_record_id": "hcc_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas), 18/366 patients (4.92%).", "Without the 2 hypermutated patients: 17/364 (4.67%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "cohort_name": "Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "altered": 18, "tested": 366, "frequency": 4.92, "frequency_excl_hypermutated": 4.67, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "366/372", "coverage_note": null, "source_id": "lihc_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "hcc_inserm_fr_2015", "cohort_name": "Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "altered": 8, "tested": 243, "frequency": 3.29, "frequency_excl_hypermutated": 2.89, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "243/243", "coverage_note": null, "source_id": "hcc_inserm_fr_2015", "is_reference": false}, {"cohort": "hcc_msk_2024", "cohort_name": "Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "1370/1370", "coverage_note": null, "source_id": "hcc_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 10.97, "width": 5.43, "reference": 16.4, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 18, "tested": 366, "frequency": 4.92, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "PRUNE2", "alteration_types": ["SNV / small indel", "amplification"], "altered": 18, "tested": 366, "frequency": 4.92, "cohort_count": 2, "frequency_range": {"min": 3.7, "max": 4.92}, "major_variants": ["P3045Qfs*11 (n=1)", "W919R (n=1)", "S576I (n=1)", "G1492V (n=1)", "Y1088S (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lihc_tcga_pan_can_atlas_2018", "source_record_id": "lihc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_inserm_fr_2015", "source_record_id": "hcc_inserm_fr_2015", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_msk_2024", "source_record_id": "hcc_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas), 18/366 patients (4.92%).", "Without the 2 hypermutated patients: 17/364 (4.67%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "cohort_name": "Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "altered": 18, "tested": 366, "frequency": 4.92, "frequency_excl_hypermutated": 4.67, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "366/372", "coverage_note": null, "source_id": "lihc_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "hcc_inserm_fr_2015", "cohort_name": "Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "altered": 9, "tested": 243, "frequency": 3.7, "frequency_excl_hypermutated": 3.31, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "243/243", "coverage_note": null, "source_id": "hcc_inserm_fr_2015", "is_reference": false}, {"cohort": "hcc_msk_2024", "cohort_name": "Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "1370/1370", "coverage_note": null, "source_id": "hcc_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 12.33, "width": 4.07, "reference": 16.4, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 18, "tested": 366, "frequency": 4.92, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "PREX2", "alteration_types": ["SNV / small indel", "amplification"], "altered": 18, "tested": 366, "frequency": 4.92, "cohort_count": 3, "frequency_range": {"min": 3.51, "max": 4.94}, "major_variants": ["L1162I (n=1)", "R363Q (n=1)", "I925N (n=1)", "A1467S (n=1)", "E121Q (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lihc_tcga_pan_can_atlas_2018", "source_record_id": "lihc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_inserm_fr_2015", "source_record_id": "hcc_inserm_fr_2015", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_msk_2024", "source_record_id": "hcc_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas), 18/366 patients (4.92%).", "Without the 2 hypermutated patients: 17/364 (4.67%).", "Largest alteration is amplification: 24/367 (6.54%) in the reference cohort's copy-number profile.", "Observed in 3 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "cohort_name": "Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "altered": 18, "tested": 366, "frequency": 4.92, "frequency_excl_hypermutated": 4.67, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "366/372", "coverage_note": null, "source_id": "lihc_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "hcc_inserm_fr_2015", "cohort_name": "Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "altered": 12, "tested": 243, "frequency": 4.94, "frequency_excl_hypermutated": 4.96, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "243/243", "coverage_note": null, "source_id": "hcc_inserm_fr_2015", "is_reference": false}, {"cohort": "hcc_msk_2024", "cohort_name": "Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "altered": 35, "tested": 998, "frequency": 3.51, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "1370/1370", "coverage_note": null, "source_id": "hcc_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 21.8, "width": 1.0, "reference": 21.8, "scale_max": 30.0}, "headline_alteration": {"kind": "amplification", "altered": 24, "tested": 367, "frequency": 6.54, "is_mutation": false}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "NBEA", "alteration_types": ["SNV / small indel", "deep deletion"], "altered": 18, "tested": 366, "frequency": 4.92, "cohort_count": 2, "frequency_range": {"min": 3.7, "max": 4.92}, "major_variants": ["D2673Rfs*17 (n=2)", "R1580H (n=2)", "Y917C (n=2)", "N1950Y (n=1)", "F403C (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lihc_tcga_pan_can_atlas_2018", "source_record_id": "lihc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_inserm_fr_2015", "source_record_id": "hcc_inserm_fr_2015", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_msk_2024", "source_record_id": "hcc_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas), 18/366 patients (4.92%).", "Without the 2 hypermutated patients: 17/364 (4.67%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "cohort_name": "Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "altered": 18, "tested": 366, "frequency": 4.92, "frequency_excl_hypermutated": 4.67, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "366/372", "coverage_note": null, "source_id": "lihc_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "hcc_inserm_fr_2015", "cohort_name": "Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "altered": 9, "tested": 243, "frequency": 3.7, "frequency_excl_hypermutated": 3.31, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "243/243", "coverage_note": null, "source_id": "hcc_inserm_fr_2015", "is_reference": false}, {"cohort": "hcc_msk_2024", "cohort_name": "Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "1370/1370", "coverage_note": null, "source_id": "hcc_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 12.33, "width": 4.07, "reference": 16.4, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 18, "tested": 366, "frequency": 4.92, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "LAMA1", "alteration_types": ["SNV / small indel", "amplification"], "altered": 18, "tested": 366, "frequency": 4.92, "cohort_count": 2, "frequency_range": {"min": 3.29, "max": 4.92}, "major_variants": ["Y2845H (n=1)", "S2615N (n=1)", "A880D (n=1)", "A989D (n=1)", "X2392_splice (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lihc_tcga_pan_can_atlas_2018", "source_record_id": "lihc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_inserm_fr_2015", "source_record_id": "hcc_inserm_fr_2015", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_msk_2024", "source_record_id": "hcc_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas), 18/366 patients (4.92%).", "Without the 2 hypermutated patients: 18/364 (4.95%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "cohort_name": "Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "altered": 18, "tested": 366, "frequency": 4.92, "frequency_excl_hypermutated": 4.95, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "366/372", "coverage_note": null, "source_id": "lihc_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "hcc_inserm_fr_2015", "cohort_name": "Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "altered": 8, "tested": 243, "frequency": 3.29, "frequency_excl_hypermutated": 2.89, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "243/243", "coverage_note": null, "source_id": "hcc_inserm_fr_2015", "is_reference": false}, {"cohort": "hcc_msk_2024", "cohort_name": "Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "1370/1370", "coverage_note": null, "source_id": "hcc_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 10.97, "width": 5.43, "reference": 16.4, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 18, "tested": 366, "frequency": 4.92, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "KEAP1", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 18, "tested": 366, "frequency": 4.92, "cohort_count": 3, "frequency_range": {"min": 1.9, "max": 4.92}, "major_variants": ["L355Sfs*37 (n=1)", "V152G (n=1)", "S592G (n=1)", "G186S (n=1)", "P278L (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lihc_tcga_pan_can_atlas_2018", "source_record_id": "lihc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_inserm_fr_2015", "source_record_id": "hcc_inserm_fr_2015", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_msk_2024", "source_record_id": "hcc_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas), 18/366 patients (4.92%).", "Without the 2 hypermutated patients: 18/364 (4.95%).", "Observed in 3 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "cohort_name": "Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "altered": 18, "tested": 366, "frequency": 4.92, "frequency_excl_hypermutated": 4.95, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "366/372", "coverage_note": null, "source_id": "lihc_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "hcc_inserm_fr_2015", "cohort_name": "Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "altered": 9, "tested": 243, "frequency": 3.7, "frequency_excl_hypermutated": 3.72, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "243/243", "coverage_note": null, "source_id": "hcc_inserm_fr_2015", "is_reference": false}, {"cohort": "hcc_msk_2024", "cohort_name": "Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "altered": 26, "tested": 1370, "frequency": 1.9, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "1370/1370", "coverage_note": null, "source_id": "hcc_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 6.33, "width": 10.07, "reference": 16.4, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 18, "tested": 366, "frequency": 4.92, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "HTT", "alteration_types": ["SNV / small indel", "deep deletion"], "altered": 18, "tested": 366, "frequency": 4.92, "cohort_count": 2, "frequency_range": {"min": 0.82, "max": 4.92}, "major_variants": ["Q3085H (n=1)", "T3026A (n=1)", "G3081A (n=1)", "W2623L (n=1)", "Q2030Afs*43 (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lihc_tcga_pan_can_atlas_2018", "source_record_id": "lihc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_inserm_fr_2015", "source_record_id": "hcc_inserm_fr_2015", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_msk_2024", "source_record_id": "hcc_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas), 18/366 patients (4.92%).", "Without the 2 hypermutated patients: 17/364 (4.67%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "cohort_name": "Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "altered": 18, "tested": 366, "frequency": 4.92, "frequency_excl_hypermutated": 4.67, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "366/372", "coverage_note": null, "source_id": "lihc_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "hcc_inserm_fr_2015", "cohort_name": "Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "altered": 2, "tested": 243, "frequency": 0.82, "frequency_excl_hypermutated": 0.83, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "243/243", "coverage_note": null, "source_id": "hcc_inserm_fr_2015", "is_reference": false}, {"cohort": "hcc_msk_2024", "cohort_name": "Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "1370/1370", "coverage_note": null, "source_id": "hcc_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 2.73, "width": 13.67, "reference": 16.4, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 18, "tested": 366, "frequency": 4.92, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "EYS", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 18, "tested": 366, "frequency": 4.92, "cohort_count": 2, "frequency_range": {"min": 2.06, "max": 4.92}, "major_variants": ["A1497D (n=1)", "N2484D (n=1)", "I1328F (n=1)", "R1252I (n=1)", "Q677* (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lihc_tcga_pan_can_atlas_2018", "source_record_id": "lihc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_inserm_fr_2015", "source_record_id": "hcc_inserm_fr_2015", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_msk_2024", "source_record_id": "hcc_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas), 18/366 patients (4.92%).", "Without the 2 hypermutated patients: 17/364 (4.67%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "cohort_name": "Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "altered": 18, "tested": 366, "frequency": 4.92, "frequency_excl_hypermutated": 4.67, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "366/372", "coverage_note": null, "source_id": "lihc_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "hcc_inserm_fr_2015", "cohort_name": "Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "altered": 5, "tested": 243, "frequency": 2.06, "frequency_excl_hypermutated": 2.07, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "243/243", "coverage_note": null, "source_id": "hcc_inserm_fr_2015", "is_reference": false}, {"cohort": "hcc_msk_2024", "cohort_name": "Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "1370/1370", "coverage_note": null, "source_id": "hcc_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 6.87, "width": 9.53, "reference": 16.4, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 18, "tested": 366, "frequency": 4.92, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "DCHS1", "alteration_types": ["SNV / small indel"], "altered": 18, "tested": 366, "frequency": 4.92, "cohort_count": 2, "frequency_range": {"min": 2.88, "max": 4.92}, "major_variants": ["C3193F (n=2)", "R112W (n=1)", "A3262P (n=1)", "R719L (n=1)", "P2857H (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lihc_tcga_pan_can_atlas_2018", "source_record_id": "lihc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_inserm_fr_2015", "source_record_id": "hcc_inserm_fr_2015", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_msk_2024", "source_record_id": "hcc_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas), 18/366 patients (4.92%).", "Without the 2 hypermutated patients: 17/364 (4.67%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "cohort_name": "Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "altered": 18, "tested": 366, "frequency": 4.92, "frequency_excl_hypermutated": 4.67, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "366/372", "coverage_note": null, "source_id": "lihc_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "hcc_inserm_fr_2015", "cohort_name": "Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "altered": 7, "tested": 243, "frequency": 2.88, "frequency_excl_hypermutated": 2.48, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "243/243", "coverage_note": null, "source_id": "hcc_inserm_fr_2015", "is_reference": false}, {"cohort": "hcc_msk_2024", "cohort_name": "Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "1370/1370", "coverage_note": null, "source_id": "hcc_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 9.6, "width": 6.8, "reference": 16.4, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 18, "tested": 366, "frequency": 4.92, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "COL6A6", "alteration_types": ["SNV / small indel"], "altered": 18, "tested": 366, "frequency": 4.92, "cohort_count": 2, "frequency_range": {"min": 1.23, "max": 4.92}, "major_variants": ["K617R (n=2)", "V663L (n=1)", "C539R (n=1)", "A1861E (n=1)", "M959R (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lihc_tcga_pan_can_atlas_2018", "source_record_id": "lihc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_inserm_fr_2015", "source_record_id": "hcc_inserm_fr_2015", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_msk_2024", "source_record_id": "hcc_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas), 18/366 patients (4.92%).", "Without the 2 hypermutated patients: 17/364 (4.67%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "cohort_name": "Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "altered": 18, "tested": 366, "frequency": 4.92, "frequency_excl_hypermutated": 4.67, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "366/372", "coverage_note": null, "source_id": "lihc_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "hcc_inserm_fr_2015", "cohort_name": "Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "altered": 3, "tested": 243, "frequency": 1.23, "frequency_excl_hypermutated": 1.24, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "243/243", "coverage_note": null, "source_id": "hcc_inserm_fr_2015", "is_reference": false}, {"cohort": "hcc_msk_2024", "cohort_name": "Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "1370/1370", "coverage_note": null, "source_id": "hcc_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 4.1, "width": 12.3, "reference": 16.4, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 18, "tested": 366, "frequency": 4.92, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "ABCA12", "alteration_types": ["SNV / small indel", "amplification"], "altered": 18, "tested": 366, "frequency": 4.92, "cohort_count": 2, "frequency_range": {"min": 1.23, "max": 4.92}, "major_variants": ["G1614E (n=2)", "T1842S (n=1)", "P1288L (n=1)", "S1064I (n=1)", "S230T (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lihc_tcga_pan_can_atlas_2018", "source_record_id": "lihc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_inserm_fr_2015", "source_record_id": "hcc_inserm_fr_2015", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_msk_2024", "source_record_id": "hcc_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas), 18/366 patients (4.92%).", "Without the 2 hypermutated patients: 16/364 (4.4%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "cohort_name": "Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "altered": 18, "tested": 366, "frequency": 4.92, "frequency_excl_hypermutated": 4.4, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "366/372", "coverage_note": null, "source_id": "lihc_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "hcc_inserm_fr_2015", "cohort_name": "Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "altered": 3, "tested": 243, "frequency": 1.23, "frequency_excl_hypermutated": 1.24, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "243/243", "coverage_note": null, "source_id": "hcc_inserm_fr_2015", "is_reference": false}, {"cohort": "hcc_msk_2024", "cohort_name": "Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "1370/1370", "coverage_note": null, "source_id": "hcc_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 4.1, "width": 12.3, "reference": 16.4, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 18, "tested": 366, "frequency": 4.92, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "PTPRQ", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 17, "tested": 366, "frequency": 4.64, "cohort_count": 2, "frequency_range": {"min": 2.88, "max": 4.64}, "major_variants": ["E1621Q (n=2)", "V1701I (n=1)", "I1839N (n=1)", "D1253Y (n=1)", "S490R (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lihc_tcga_pan_can_atlas_2018", "source_record_id": "lihc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_inserm_fr_2015", "source_record_id": "hcc_inserm_fr_2015", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_msk_2024", "source_record_id": "hcc_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas), 17/366 patients (4.64%).", "Without the 2 hypermutated patients: 16/364 (4.4%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "cohort_name": "Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "altered": 17, "tested": 366, "frequency": 4.64, "frequency_excl_hypermutated": 4.4, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "366/372", "coverage_note": null, "source_id": "lihc_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "hcc_inserm_fr_2015", "cohort_name": "Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "altered": 7, "tested": 243, "frequency": 2.88, "frequency_excl_hypermutated": 2.48, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "243/243", "coverage_note": null, "source_id": "hcc_inserm_fr_2015", "is_reference": false}, {"cohort": "hcc_msk_2024", "cohort_name": "Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "1370/1370", "coverage_note": null, "source_id": "hcc_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 9.6, "width": 5.87, "reference": 15.47, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 17, "tested": 366, "frequency": 4.64, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "PKHD1", "alteration_types": ["SNV / small indel", "amplification"], "altered": 17, "tested": 366, "frequency": 4.64, "cohort_count": 2, "frequency_range": {"min": 3.7, "max": 4.64}, "major_variants": ["P1258R (n=1)", "I3909M (n=1)", "I2539T (n=1)", "V595F (n=1)", "N977D (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lihc_tcga_pan_can_atlas_2018", "source_record_id": "lihc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_inserm_fr_2015", "source_record_id": "hcc_inserm_fr_2015", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_msk_2024", "source_record_id": "hcc_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas), 17/366 patients (4.64%).", "Without the 2 hypermutated patients: 16/364 (4.4%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "cohort_name": "Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "altered": 17, "tested": 366, "frequency": 4.64, "frequency_excl_hypermutated": 4.4, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "366/372", "coverage_note": null, "source_id": "lihc_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "hcc_inserm_fr_2015", "cohort_name": "Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "altered": 9, "tested": 243, "frequency": 3.7, "frequency_excl_hypermutated": 3.31, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "243/243", "coverage_note": null, "source_id": "hcc_inserm_fr_2015", "is_reference": false}, {"cohort": "hcc_msk_2024", "cohort_name": "Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "1370/1370", "coverage_note": null, "source_id": "hcc_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 12.33, "width": 3.14, "reference": 15.47, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 17, "tested": 366, "frequency": 4.64, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "MYT1L", "alteration_types": ["SNV / small indel", "amplification"], "altered": 17, "tested": 366, "frequency": 4.64, "cohort_count": 2, "frequency_range": {"min": 1.23, "max": 4.64}, "major_variants": ["R358C (n=1)", "N1134S (n=1)", "G1045R (n=1)", "E27* (n=1)", "D119E (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lihc_tcga_pan_can_atlas_2018", "source_record_id": "lihc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_inserm_fr_2015", "source_record_id": "hcc_inserm_fr_2015", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_msk_2024", "source_record_id": "hcc_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas), 17/366 patients (4.64%).", "Without the 2 hypermutated patients: 17/364 (4.67%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "cohort_name": "Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "altered": 17, "tested": 366, "frequency": 4.64, "frequency_excl_hypermutated": 4.67, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "366/372", "coverage_note": null, "source_id": "lihc_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "hcc_inserm_fr_2015", "cohort_name": "Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "altered": 3, "tested": 243, "frequency": 1.23, "frequency_excl_hypermutated": 1.24, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "243/243", "coverage_note": null, "source_id": "hcc_inserm_fr_2015", "is_reference": false}, {"cohort": "hcc_msk_2024", "cohort_name": "Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "1370/1370", "coverage_note": null, "source_id": "hcc_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 4.1, "width": 11.37, "reference": 15.47, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 17, "tested": 366, "frequency": 4.64, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "KMT2C", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 17, "tested": 366, "frequency": 4.64, "cohort_count": 3, "frequency_range": {"min": 2.47, "max": 5.04}, "major_variants": ["V9M (n=1)", "*4912Lext*36 (n=1)", "E1623* (n=1)", "H367D (n=1)", "C310F (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lihc_tcga_pan_can_atlas_2018", "source_record_id": "lihc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_inserm_fr_2015", "source_record_id": "hcc_inserm_fr_2015", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_msk_2024", "source_record_id": "hcc_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas), 17/366 patients (4.64%).", "Without the 2 hypermutated patients: 17/364 (4.67%).", "Observed in 3 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "cohort_name": "Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "altered": 17, "tested": 366, "frequency": 4.64, "frequency_excl_hypermutated": 4.67, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "366/372", "coverage_note": null, "source_id": "lihc_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "hcc_inserm_fr_2015", "cohort_name": "Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "altered": 6, "tested": 243, "frequency": 2.47, "frequency_excl_hypermutated": 2.07, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "243/243", "coverage_note": null, "source_id": "hcc_inserm_fr_2015", "is_reference": false}, {"cohort": "hcc_msk_2024", "cohort_name": "Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "altered": 69, "tested": 1370, "frequency": 5.04, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "1370/1370", "coverage_note": null, "source_id": "hcc_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 8.23, "width": 8.57, "reference": 15.47, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 17, "tested": 366, "frequency": 4.64, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "FAT2", "alteration_types": ["SNV / small indel", "amplification"], "altered": 17, "tested": 366, "frequency": 4.64, "cohort_count": 2, "frequency_range": {"min": 2.88, "max": 4.64}, "major_variants": ["D882G (n=1)", "I138S (n=1)", "R1006S (n=1)", "L1514F (n=1)", "X1316_splice (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lihc_tcga_pan_can_atlas_2018", "source_record_id": "lihc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_inserm_fr_2015", "source_record_id": "hcc_inserm_fr_2015", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_msk_2024", "source_record_id": "hcc_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas), 17/366 patients (4.64%).", "Without the 2 hypermutated patients: 16/364 (4.4%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "cohort_name": "Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "altered": 17, "tested": 366, "frequency": 4.64, "frequency_excl_hypermutated": 4.4, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "366/372", "coverage_note": null, "source_id": "lihc_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "hcc_inserm_fr_2015", "cohort_name": "Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "altered": 7, "tested": 243, "frequency": 2.88, "frequency_excl_hypermutated": 2.48, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "243/243", "coverage_note": null, "source_id": "hcc_inserm_fr_2015", "is_reference": false}, {"cohort": "hcc_msk_2024", "cohort_name": "Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "1370/1370", "coverage_note": null, "source_id": "hcc_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 9.6, "width": 5.87, "reference": 15.47, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 17, "tested": 366, "frequency": 4.64, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "LRRIQ1", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 16, "tested": 366, "frequency": 4.37, "cohort_count": 2, "frequency_range": {"min": 2.88, "max": 4.37}, "major_variants": ["R491Tfs*14 (n=1)", "I1474F (n=1)", "K1335E (n=1)", "S618L (n=1)", "S1466* (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lihc_tcga_pan_can_atlas_2018", "source_record_id": "lihc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_inserm_fr_2015", "source_record_id": "hcc_inserm_fr_2015", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_msk_2024", "source_record_id": "hcc_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas), 16/366 patients (4.37%).", "Without the 2 hypermutated patients: 16/364 (4.4%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "cohort_name": "Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "altered": 16, "tested": 366, "frequency": 4.37, "frequency_excl_hypermutated": 4.4, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "366/372", "coverage_note": null, "source_id": "lihc_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "hcc_inserm_fr_2015", "cohort_name": "Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "altered": 7, "tested": 243, "frequency": 2.88, "frequency_excl_hypermutated": 2.48, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "243/243", "coverage_note": null, "source_id": "hcc_inserm_fr_2015", "is_reference": false}, {"cohort": "hcc_msk_2024", "cohort_name": "Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "1370/1370", "coverage_note": null, "source_id": "hcc_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 9.6, "width": 4.97, "reference": 14.57, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 16, "tested": 366, "frequency": 4.37, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "FMN2", "alteration_types": ["SNV / small indel", "amplification"], "altered": 16, "tested": 366, "frequency": 4.37, "cohort_count": 2, "frequency_range": {"min": 1.65, "max": 4.37}, "major_variants": ["P909S (n=1)", "A357V (n=1)", "A526V (n=1)", "X663_splice (n=1)", "I1074L (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lihc_tcga_pan_can_atlas_2018", "source_record_id": "lihc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_inserm_fr_2015", "source_record_id": "hcc_inserm_fr_2015", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_msk_2024", "source_record_id": "hcc_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas), 16/366 patients (4.37%).", "Without the 2 hypermutated patients: 16/364 (4.4%).", "Largest alteration is amplification: 23/367 (6.27%) in the reference cohort's copy-number profile.", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "cohort_name": "Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "altered": 16, "tested": 366, "frequency": 4.37, "frequency_excl_hypermutated": 4.4, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "366/372", "coverage_note": null, "source_id": "lihc_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "hcc_inserm_fr_2015", "cohort_name": "Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "altered": 4, "tested": 243, "frequency": 1.65, "frequency_excl_hypermutated": 1.65, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "243/243", "coverage_note": null, "source_id": "hcc_inserm_fr_2015", "is_reference": false}, {"cohort": "hcc_msk_2024", "cohort_name": "Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "1370/1370", "coverage_note": null, "source_id": "hcc_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 20.9, "width": 1.0, "reference": 20.9, "scale_max": 30.0}, "headline_alteration": {"kind": "amplification", "altered": 23, "tested": 367, "frequency": 6.27, "is_mutation": false}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "FCGBP", "alteration_types": ["SNV / small indel", "amplification"], "altered": 16, "tested": 366, "frequency": 4.37, "cohort_count": 2, "frequency_range": {"min": 3.29, "max": 4.37}, "major_variants": ["R5150H (n=1)", "C3889F (n=1)", "G312V (n=1)", "G805C (n=1)", "L3740M (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lihc_tcga_pan_can_atlas_2018", "source_record_id": "lihc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_inserm_fr_2015", "source_record_id": "hcc_inserm_fr_2015", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_msk_2024", "source_record_id": "hcc_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas), 16/366 patients (4.37%).", "Without the 2 hypermutated patients: 16/364 (4.4%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "cohort_name": "Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "altered": 16, "tested": 366, "frequency": 4.37, "frequency_excl_hypermutated": 4.4, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "366/372", "coverage_note": null, "source_id": "lihc_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "hcc_inserm_fr_2015", "cohort_name": "Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "altered": 8, "tested": 243, "frequency": 3.29, "frequency_excl_hypermutated": 3.31, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "243/243", "coverage_note": null, "source_id": "hcc_inserm_fr_2015", "is_reference": false}, {"cohort": "hcc_msk_2024", "cohort_name": "Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "1370/1370", "coverage_note": null, "source_id": "hcc_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 10.97, "width": 3.6, "reference": 14.57, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 16, "tested": 366, "frequency": 4.37, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}], "variants": [], "genomic_events": [{"event_type": "copy_number", "gene": "CACNA1E", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "CACNA1E amplification", "genomic_coordinate": null, "observed": 29, "observed_status": "observed", "observed_unit": "patients", "tested": 367, "tested_status": "observed", "tested_unit": "patients", "frequency": 7.9, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["lihc_tcga_pan_can_atlas_2018"], "source_ids": ["lihc_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "FGF19", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "FGF19 amplification", "genomic_coordinate": null, "observed": 25, "observed_status": "observed", "observed_unit": "patients", "tested": 367, "tested_status": "observed", "tested_unit": "patients", "frequency": 6.81, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["lihc_tcga_pan_can_atlas_2018"], "source_ids": ["lihc_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "VEGFA", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "VEGFA amplification", "genomic_coordinate": null, "observed": 24, "observed_status": "observed", "observed_unit": "patients", "tested": 367, "tested_status": "observed", "tested_unit": "patients", "frequency": 6.54, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["lihc_tcga_pan_can_atlas_2018"], "source_ids": ["lihc_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "PREX2", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "PREX2 amplification", "genomic_coordinate": null, "observed": 24, "observed_status": "observed", "observed_unit": "patients", "tested": 367, "tested_status": "observed", "tested_unit": "patients", "frequency": 6.54, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["lihc_tcga_pan_can_atlas_2018"], "source_ids": ["lihc_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "FMN2", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "FMN2 amplification", "genomic_coordinate": null, "observed": 23, "observed_status": "observed", "observed_unit": "patients", "tested": 367, "tested_status": "observed", "tested_unit": "patients", "frequency": 6.27, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["lihc_tcga_pan_can_atlas_2018"], "source_ids": ["lihc_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "TERT", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "TERT amplification", "genomic_coordinate": null, "observed": 20, "observed_status": "observed", "observed_unit": "patients", "tested": 367, "tested_status": "observed", "tested_unit": "patients", "frequency": 5.45, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["lihc_tcga_pan_can_atlas_2018"], "source_ids": ["lihc_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "PRKDC", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "PRKDC amplification", "genomic_coordinate": null, "observed": 20, "observed_status": "observed", "observed_unit": "patients", "tested": 367, "tested_status": "observed", "tested_unit": "patients", "frequency": 5.45, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["lihc_tcga_pan_can_atlas_2018"], "source_ids": ["lihc_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "RB1", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "deep deletion", "event_label": "RB1 deep deletion", "genomic_coordinate": null, "observed": 19, "observed_status": "observed", "observed_unit": "patients", "tested": 367, "tested_status": "observed", "tested_unit": "patients", "frequency": 5.18, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["lihc_tcga_pan_can_atlas_2018"], "source_ids": ["lihc_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "FASN", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "FASN amplification", "genomic_coordinate": null, "observed": 18, "observed_status": "observed", "observed_unit": "patients", "tested": 367, "tested_status": "observed", "tested_unit": "patients", "frequency": 4.9, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["lihc_tcga_pan_can_atlas_2018"], "source_ids": ["lihc_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "FGF19", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "FGF19 amplification", "genomic_coordinate": null, "observed": 60, "observed_status": "observed", "observed_unit": "patients", "tested": 1370, "tested_status": "observed", "tested_unit": "patients", "frequency": 4.38, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["hcc_msk_2024"], "source_ids": ["hcc_msk_2024_cna"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "EYS", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "EYS amplification", "genomic_coordinate": null, "observed": 14, "observed_status": "observed", "observed_unit": "patients", "tested": 367, "tested_status": "observed", "tested_unit": "patients", "frequency": 3.81, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["lihc_tcga_pan_can_atlas_2018"], "source_ids": ["lihc_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "TP53", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "deep deletion", "event_label": "TP53 deep deletion", "genomic_coordinate": null, "observed": 9, "observed_status": "observed", "observed_unit": "patients", "tested": 367, "tested_status": "observed", "tested_unit": "patients", "frequency": 2.45, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["lihc_tcga_pan_can_atlas_2018"], "source_ids": ["lihc_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "MET", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "MET amplification", "genomic_coordinate": null, "observed": 9, "observed_status": "observed", "observed_unit": "patients", "tested": 367, "tested_status": "observed", "tested_unit": "patients", "frequency": 2.45, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["lihc_tcga_pan_can_atlas_2018"], "source_ids": ["lihc_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "PKHD1", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "PKHD1 amplification", "genomic_coordinate": null, "observed": 8, "observed_status": "observed", "observed_unit": "patients", "tested": 367, "tested_status": "observed", "tested_unit": "patients", "frequency": 2.18, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["lihc_tcga_pan_can_atlas_2018"], "source_ids": ["lihc_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}], "modality_summary": [{"modality": "SNV / small indel", "available_cohorts": 3, "total_cohorts": 3}, {"modality": "Copy number (discrete)", "available_cohorts": 2, "total_cohorts": 3}, {"modality": "Structural variant (present, not read)", "available_cohorts": 2, "total_cohorts": 3}], "chromosome_summary": [], "cohorts": [{"name": "Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "source": "cBioPortal", "accession": "lihc_tcga_pan_can_atlas_2018", "patients": {"value": 366, "status": "observed", "unit": "patients"}, "samples": {"value": 366, "status": "observed", "unit": "samples"}, "disease_subtype": "Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "assay_type": "exome or genome", "sequencing_method": "WES (366)", "genome_build": "hg19", "alteration_types_available": ["SNV", "small indel", "amplification", "deep deletion", "structural variant (profile present, not read)"], "genes_assayed": "all coding genes", "primary_or_metastatic": null, "age_group": null, "retrieved_at": "2026-09-18", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "source_record_id": "lihc_tcga_pan_can_atlas_2018", "is_demo": false, "assay_coverage": {"patients_with_calls": 366, "patients_in_roster": 366, "frequencies_computed": true, "samples_sequenced": 366, "samples_in_study": 372, "hypermutated_patients": 2, "median_mutations_per_sample": 79.0, "reason": null}}, {"name": "Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "source": "cBioPortal", "accession": "hcc_inserm_fr_2015", "patients": {"value": 243, "status": "observed", "unit": "patients"}, "samples": {"value": 243, "status": "observed", "unit": "samples"}, "disease_subtype": "Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "assay_type": "exome or genome", "sequencing_method": "WES (243)", "genome_build": "hg19", "alteration_types_available": ["SNV", "small indel"], "genes_assayed": "all coding genes", "primary_or_metastatic": null, "age_group": null, "retrieved_at": "2026-09-18", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "source_record_id": "hcc_inserm_fr_2015", "is_demo": false, "assay_coverage": {"patients_with_calls": 243, "patients_in_roster": 243, "frequencies_computed": true, "samples_sequenced": 243, "samples_in_study": 243, "hypermutated_patients": 1, "median_mutations_per_sample": 61, "reason": null}}, {"name": "Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "source": "cBioPortal", "accession": "hcc_msk_2024", "patients": {"value": 1370, "status": "observed", "unit": "patients"}, "samples": {"value": 1370, "status": "observed", "unit": "samples"}, "disease_subtype": "Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "assay_type": "targeted panel", "sequencing_method": "IMPACT468 (777), IMPACT410 (286), IMPACT505 (221), IMPACT341 (86)", "genome_build": "hg19", "alteration_types_available": ["SNV", "small indel", "amplification", "deep deletion", "structural variant (profile present, not read)"], "genes_assayed": "panel genes only; per-gene denominators", "primary_or_metastatic": null, "age_group": null, "retrieved_at": "2026-09-18", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "source_record_id": "hcc_msk_2024", "is_demo": false, "assay_coverage": {"patients_with_calls": 1370, "patients_in_roster": 1370, "frequencies_computed": true, "samples_sequenced": 1370, "samples_in_study": 1370, "hypermutated_patients": 0, "median_mutations_per_sample": 3.0, "reason": null}}], "sources": [{"source_name": "cBioPortal · Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lihc_tcga_pan_can_atlas_2018", "source_record_id": "lihc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinomas (INSERM, Nat Genet 2015)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_inserm_fr_2015", "source_record_id": "hcc_inserm_fr_2015", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=hcc_msk_2024", "source_record_id": "hcc_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "limitations": ["A cBioPortal public-API snapshot retrieved 2026-09-18; the page does not refresh source data at request time.", "Counts are patients with at least one non-silent call in the study's sequenced sample list; silent, intronic and UTR calls are excluded.", "For targeted-panel cohorts each gene divides by the patients whose panel carried it; a gene absent from the panel is shown as not assayed, not as zero.", "Copy-number rows use discrete calls (2 = high-level amplification, −2 = deep deletion) against the cohort's copy-number sample list, which is a different roster from the sequenced one.", "Cohorts are not pooled. Cross-study patient overlap has not been checked and no disease-wide frequency is reported.", "Structural variants and fusions are not read in this snapshot even where the study carries a profile; germline variants, mutational signatures, TMB and MSI are not reported.", "The gene set is the briefing's curated targets plus the reference cohort's most frequently mutated genes; it is not genome-wide."], "answer_block": ["In Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas) (366 sequenced patients, exome or genome), the most frequently altered of the 47 genes shown are TP53 29.51%, CTNNB1 25.96%, ALB 12.84%, CACNA1E 7.9% (amplification), ARID1A 7.65%. Each figure divides by the patients on whom that gene could be called.", "2 of 366 patients are hypermutated (more than 790 non-silent mutations, ten times the cohort median of 79); every gene's frequency without them is beside the headline.", "Of the briefing's 11 curated targets, 3 are altered in under 2% of this cohort (FGFR4, KDR, GPC3): targets by expression, dependency or drug label, not by mutation. Frequency is not targetability, in either direction.", "3 cohorts are shown and none are pooled; overlap between them has not been checked and there is no disease-wide percentage."], "key_findings": [{"finding": "TP53 is mutated in 108 of 366 patients in Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas).", "numerator": 108, "denominator": 366, "frequency": 29.51, "cohorts": 3, "evidence_confidence": "moderate", "source": "lihc_tcga_pan_can_atlas_2018", "retrieved_at": "2026-09-18"}, {"finding": "CTNNB1 is mutated in 95 of 366 patients in Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas).", "numerator": 95, "denominator": 366, "frequency": 25.96, "cohorts": 3, "evidence_confidence": "moderate", "source": "lihc_tcga_pan_can_atlas_2018", "retrieved_at": "2026-09-18"}, {"finding": "ALB is mutated in 47 of 366 patients in Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas).", "numerator": 47, "denominator": 366, "frequency": 12.84, "cohorts": 3, "evidence_confidence": "moderate", "source": "lihc_tcga_pan_can_atlas_2018", "retrieved_at": "2026-09-18"}], "research_gaps": [{"kind": "Structural variants", "text": "Read the structural-variant profiles the studies carry; fusions are the defining event in several of these diseases."}, {"kind": "Context", "text": "Stage, subtype, age and treatment line are not attached to any count; the cohorts differ on all four."}, {"kind": "Interpretation", "text": "Activating versus inactivating, actionable versus not, and evidence level are not inferred here; the briefing's target table carries the drug and trial facts."}], "observations": [], "data_status": "PUBLIC SOURCE SNAPSHOT", "is_demo": false, "reference_cohort": "lihc_tcga_pan_can_atlas_2018", "region_events": [], "matrix": [{"label": "TERT", "kind": "SNV / small indel", "gene": "TERT", "cells": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 0.55, "altered": 2, "tested": 366, "note": null}, {"cohort": "hcc_inserm_fr_2015", "status": "observed", "frequency": 1.23, "altered": 3, "tested": 243, "note": null}, {"cohort": "hcc_msk_2024", "status": "observed", "frequency": 0.36, "altered": 5, "tested": 1370, "note": null}]}, {"label": "TERT", "kind": "amplification", "gene": "TERT", "cells": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 5.45, "altered": 20, "tested": 367, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "hcc_inserm_fr_2015", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "No copy-number profile is connected for this cohort."}, {"cohort": "hcc_msk_2024", "status": "observed", "frequency": 1.75, "altered": 24, "tested": 1370, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "TP53", "kind": "SNV / small indel", "gene": "TP53", "cells": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 29.51, "altered": 108, "tested": 366, "note": null}, {"cohort": "hcc_inserm_fr_2015", "status": "observed", "frequency": 22.22, "altered": 54, "tested": 243, "note": null}, {"cohort": "hcc_msk_2024", "status": "observed", "frequency": 34.01, "altered": 466, "tested": 1370, "note": null}]}, {"label": "TP53", "kind": "deep deletion", "gene": "TP53", "cells": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 2.45, "altered": 9, "tested": 367, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "hcc_inserm_fr_2015", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "No copy-number profile is connected for this cohort."}, {"cohort": "hcc_msk_2024", "status": "observed", "frequency": 0.66, "altered": 9, "tested": 1370, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "CTNNB1", "kind": "SNV / small indel", "gene": "CTNNB1", "cells": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 25.96, "altered": 95, "tested": 366, "note": null}, {"cohort": "hcc_inserm_fr_2015", "status": "observed", "frequency": 36.21, "altered": 88, "tested": 243, "note": null}, {"cohort": "hcc_msk_2024", "status": "observed", "frequency": 9.64, "altered": 132, "tested": 1370, "note": null}]}, {"label": "AXIN1", "kind": "SNV / small indel", "gene": "AXIN1", "cells": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 6.83, "altered": 25, "tested": 366, "note": null}, {"cohort": "hcc_inserm_fr_2015", "status": "observed", "frequency": 8.64, "altered": 21, "tested": 243, "note": null}, {"cohort": "hcc_msk_2024", "status": "observed", "frequency": 2.85, "altered": 39, "tested": 1370, "note": null}]}, {"label": "ARID1A", "kind": "SNV / small indel", "gene": "ARID1A", "cells": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 7.65, "altered": 28, "tested": 366, "note": null}, {"cohort": "hcc_inserm_fr_2015", "status": "observed", "frequency": 9.88, "altered": 24, "tested": 243, "note": null}, {"cohort": "hcc_msk_2024", "status": "observed", "frequency": 16.5, "altered": 226, "tested": 1370, "note": null}]}, {"label": "MET", "kind": "SNV / small indel", "gene": "MET", "cells": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 0.55, "altered": 2, "tested": 366, "note": null}, {"cohort": "hcc_inserm_fr_2015", "status": "observed", "frequency": 0.41, "altered": 1, "tested": 243, "note": null}, {"cohort": "hcc_msk_2024", "status": "observed", "frequency": 0.73, "altered": 10, "tested": 1370, "note": null}]}, {"label": "MET", "kind": "amplification", "gene": "MET", "cells": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 2.45, "altered": 9, "tested": 367, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "hcc_inserm_fr_2015", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "No copy-number profile is connected for this cohort."}, {"cohort": "hcc_msk_2024", "status": "observed", "frequency": 1.31, "altered": 18, "tested": 1370, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "FGF19", "kind": "SNV / small indel", "gene": "FGF19", "cells": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 366, "note": null}, {"cohort": "hcc_inserm_fr_2015", "status": "observed", "frequency": 0.41, "altered": 1, "tested": 243, "note": null}, {"cohort": "hcc_msk_2024", "status": "observed", "frequency": 0.15, "altered": 2, "tested": 1370, "note": null}]}, {"label": "FGF19", "kind": "amplification", "gene": "FGF19", "cells": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 6.81, "altered": 25, "tested": 367, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "hcc_inserm_fr_2015", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "No copy-number profile is connected for this cohort."}, {"cohort": "hcc_msk_2024", "status": "observed", "frequency": 4.38, "altered": 60, "tested": 1370, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "FGFR4", "kind": "SNV / small indel", "gene": "FGFR4", "cells": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 1.09, "altered": 4, "tested": 366, "note": null}, {"cohort": "hcc_inserm_fr_2015", "status": "observed", "frequency": 0.41, "altered": 1, "tested": 243, "note": null}, {"cohort": "hcc_msk_2024", "status": "observed", "frequency": 0.36, "altered": 5, "tested": 1370, "note": null}]}, {"label": "KDR", "kind": "SNV / small indel", "gene": "KDR", "cells": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 1.91, "altered": 7, "tested": 366, "note": null}, {"cohort": "hcc_inserm_fr_2015", "status": "observed", "frequency": 0.82, "altered": 2, "tested": 243, "note": null}, {"cohort": "hcc_msk_2024", "status": "observed", "frequency": 1.31, "altered": 18, "tested": 1370, "note": null}]}, {"label": "VEGFA", "kind": "SNV / small indel", "gene": "VEGFA", "cells": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 366, "note": null}, {"cohort": "hcc_inserm_fr_2015", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 243, "note": null}, {"cohort": "hcc_msk_2024", "status": "observed", "frequency": 0.23, "altered": 3, "tested": 1284, "note": null}]}, {"label": "VEGFA", "kind": "amplification", "gene": "VEGFA", "cells": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 6.54, "altered": 24, "tested": 367, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "hcc_inserm_fr_2015", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "No copy-number profile is connected for this cohort."}, {"cohort": "hcc_msk_2024", "status": "observed", "frequency": 1.61, "altered": 22, "tested": 1370, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "GPC3", "kind": "SNV / small indel", "gene": "GPC3", "cells": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 0.55, "altered": 2, "tested": 366, "note": null}, {"cohort": "hcc_inserm_fr_2015", "status": "observed", "frequency": 0.41, "altered": 1, "tested": 243, "note": null}, {"cohort": "hcc_msk_2024", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "ALB", "kind": "SNV / small indel", "gene": "ALB", "cells": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 12.84, "altered": 47, "tested": 366, "note": null}, {"cohort": "hcc_inserm_fr_2015", "status": "observed", "frequency": 10.7, "altered": 26, "tested": 243, "note": null}, {"cohort": "hcc_msk_2024", "status": "observed", "frequency": 8.14, "altered": 18, "tested": 221, "note": null}]}, {"label": "CACNA1E", "kind": "SNV / small indel", "gene": "CACNA1E", "cells": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 7.65, "altered": 28, "tested": 366, "note": null}, {"cohort": "hcc_inserm_fr_2015", "status": "observed", "frequency": 2.47, "altered": 6, "tested": 243, "note": null}, {"cohort": "hcc_msk_2024", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "CACNA1E", "kind": "amplification", "gene": "CACNA1E", "cells": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 7.9, "altered": 29, "tested": 367, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "hcc_inserm_fr_2015", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "No copy-number profile is connected for this cohort."}, {"cohort": "hcc_msk_2024", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 1370, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "PRKDC", "kind": "SNV / small indel", "gene": "PRKDC", "cells": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 6.01, "altered": 22, "tested": 366, "note": null}, {"cohort": "hcc_inserm_fr_2015", "status": "observed", "frequency": 2.06, "altered": 5, "tested": 243, "note": null}, {"cohort": "hcc_msk_2024", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "PRKDC", "kind": "amplification", "gene": "PRKDC", "cells": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 5.45, "altered": 20, "tested": 367, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "hcc_inserm_fr_2015", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "No copy-number profile is connected for this cohort."}, {"cohort": "hcc_msk_2024", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 1370, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "DOCK2", "kind": "SNV / small indel", "gene": "DOCK2", "cells": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 6.01, "altered": 22, "tested": 366, "note": null}, {"cohort": "hcc_inserm_fr_2015", "status": "observed", "frequency": 3.7, "altered": 9, "tested": 243, "note": null}, {"cohort": "hcc_msk_2024", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "WDR87", "kind": "SNV / small indel", "gene": "WDR87", "cells": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 5.46, "altered": 20, "tested": 366, "note": null}, {"cohort": "hcc_inserm_fr_2015", "status": "observed", "frequency": 2.47, "altered": 6, "tested": 243, "note": null}, {"cohort": "hcc_msk_2024", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "SDK1", "kind": "SNV / small indel", "gene": "SDK1", "cells": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 5.46, "altered": 20, "tested": 366, "note": null}, {"cohort": "hcc_inserm_fr_2015", "status": "observed", "frequency": 3.29, "altered": 8, "tested": 243, "note": null}, {"cohort": "hcc_msk_2024", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "HERC2", "kind": "SNV / small indel", "gene": "HERC2", "cells": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 5.46, "altered": 20, "tested": 366, "note": null}, {"cohort": "hcc_inserm_fr_2015", "status": "observed", "frequency": 2.88, "altered": 7, "tested": 243, "note": null}, {"cohort": "hcc_msk_2024", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "FRAS1", "kind": "SNV / small indel", "gene": "FRAS1", "cells": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 5.46, "altered": 20, "tested": 366, "note": null}, {"cohort": "hcc_inserm_fr_2015", "status": "observed", "frequency": 5.35, "altered": 13, "tested": 243, "note": null}, {"cohort": "hcc_msk_2024", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "BAP1", "kind": "SNV / small indel", "gene": "BAP1", "cells": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 5.46, "altered": 20, "tested": 366, "note": null}, {"cohort": "hcc_inserm_fr_2015", "status": "observed", "frequency": 1.65, "altered": 4, "tested": 243, "note": null}, {"cohort": "hcc_msk_2024", "status": "observed", "frequency": 8.54, "altered": 117, "tested": 1370, "note": null}]}, {"label": "RB1", "kind": "SNV / small indel", "gene": "RB1", "cells": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 5.19, "altered": 19, "tested": 366, "note": null}, {"cohort": "hcc_inserm_fr_2015", "status": "observed", "frequency": 3.29, "altered": 8, "tested": 243, "note": null}, {"cohort": "hcc_msk_2024", "status": "observed", "frequency": 3.21, "altered": 44, "tested": 1370, "note": null}]}, {"label": "RB1", "kind": "deep deletion", "gene": "RB1", "cells": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 5.18, "altered": 19, "tested": 367, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "hcc_inserm_fr_2015", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "No copy-number profile is connected for this cohort."}, {"cohort": "hcc_msk_2024", "status": "observed", "frequency": 1.24, "altered": 17, "tested": 1370, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "PCDH15", "kind": "SNV / small indel", "gene": "PCDH15", "cells": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 5.19, "altered": 19, "tested": 366, "note": null}, {"cohort": "hcc_inserm_fr_2015", "status": "observed", "frequency": 6.17, "altered": 15, "tested": 243, "note": null}, {"cohort": "hcc_msk_2024", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "LRP1", "kind": "SNV / small indel", "gene": "LRP1", "cells": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 5.19, "altered": 19, "tested": 366, "note": null}, {"cohort": "hcc_inserm_fr_2015", "status": "observed", "frequency": 2.47, "altered": 6, "tested": 243, "note": null}, {"cohort": "hcc_msk_2024", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "KMT2D", "kind": "SNV / small indel", "gene": "KMT2D", "cells": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 5.19, "altered": 19, "tested": 366, "note": null}, {"cohort": "hcc_inserm_fr_2015", "status": "observed", "frequency": 5.76, "altered": 14, "tested": 243, "note": null}, {"cohort": "hcc_msk_2024", "status": "observed", "frequency": 4.67, "altered": 64, "tested": 1370, "note": null}]}, {"label": "FREM2", "kind": "SNV / small indel", "gene": "FREM2", "cells": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 5.19, "altered": 19, "tested": 366, "note": null}, {"cohort": "hcc_inserm_fr_2015", "status": "observed", "frequency": 2.88, "altered": 7, "tested": 243, "note": null}, {"cohort": "hcc_msk_2024", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "FASN", "kind": "SNV / small indel", "gene": "FASN", "cells": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 5.19, "altered": 19, "tested": 366, "note": null}, {"cohort": "hcc_inserm_fr_2015", "status": "observed", "frequency": 3.7, "altered": 9, "tested": 243, "note": null}, {"cohort": "hcc_msk_2024", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "FASN", "kind": "amplification", "gene": "FASN", "cells": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 4.9, "altered": 18, "tested": 367, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "hcc_inserm_fr_2015", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "No copy-number profile is connected for this cohort."}, {"cohort": "hcc_msk_2024", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 1370, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "BIRC6", "kind": "SNV / small indel", "gene": "BIRC6", "cells": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 5.19, "altered": 19, "tested": 366, "note": null}, {"cohort": "hcc_inserm_fr_2015", "status": "observed", "frequency": 3.7, "altered": 9, "tested": 243, "note": null}, {"cohort": "hcc_msk_2024", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "ARID2", "kind": "SNV / small indel", "gene": "ARID2", "cells": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 5.19, "altered": 19, "tested": 366, "note": null}, {"cohort": "hcc_inserm_fr_2015", "status": "observed", "frequency": 6.17, "altered": 15, "tested": 243, "note": null}, {"cohort": "hcc_msk_2024", "status": "observed", "frequency": 4.89, "altered": 67, "tested": 1370, "note": null}]}, {"label": "UNC80", "kind": "SNV / small indel", "gene": "UNC80", "cells": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 4.92, "altered": 18, "tested": 366, "note": null}, {"cohort": "hcc_inserm_fr_2015", "status": "observed", "frequency": 3.29, "altered": 8, "tested": 243, "note": null}, {"cohort": "hcc_msk_2024", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "PRUNE2", "kind": "SNV / small indel", "gene": "PRUNE2", "cells": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 4.92, "altered": 18, "tested": 366, "note": null}, {"cohort": "hcc_inserm_fr_2015", "status": "observed", "frequency": 3.7, "altered": 9, "tested": 243, "note": null}, {"cohort": "hcc_msk_2024", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "PREX2", "kind": "SNV / small indel", "gene": "PREX2", "cells": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 4.92, "altered": 18, "tested": 366, "note": null}, {"cohort": "hcc_inserm_fr_2015", "status": "observed", "frequency": 4.94, "altered": 12, "tested": 243, "note": null}, {"cohort": "hcc_msk_2024", "status": "observed", "frequency": 3.51, "altered": 35, "tested": 998, "note": null}]}, {"label": "PREX2", "kind": "amplification", "gene": "PREX2", "cells": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 6.54, "altered": 24, "tested": 367, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "hcc_inserm_fr_2015", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "No copy-number profile is connected for this cohort."}, {"cohort": "hcc_msk_2024", "status": "observed", "frequency": 1.02, "altered": 14, "tested": 1370, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "NBEA", "kind": "SNV / small indel", "gene": "NBEA", "cells": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 4.92, "altered": 18, "tested": 366, "note": null}, {"cohort": "hcc_inserm_fr_2015", "status": "observed", "frequency": 3.7, "altered": 9, "tested": 243, "note": null}, {"cohort": "hcc_msk_2024", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "LAMA1", "kind": "SNV / small indel", "gene": "LAMA1", "cells": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 4.92, "altered": 18, "tested": 366, "note": null}, {"cohort": "hcc_inserm_fr_2015", "status": "observed", "frequency": 3.29, "altered": 8, "tested": 243, "note": null}, {"cohort": "hcc_msk_2024", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "KEAP1", "kind": "SNV / small indel", "gene": "KEAP1", "cells": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 4.92, "altered": 18, "tested": 366, "note": null}, {"cohort": "hcc_inserm_fr_2015", "status": "observed", "frequency": 3.7, "altered": 9, "tested": 243, "note": null}, {"cohort": "hcc_msk_2024", "status": "observed", "frequency": 1.9, "altered": 26, "tested": 1370, "note": null}]}, {"label": "HTT", "kind": "SNV / small indel", "gene": "HTT", "cells": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 4.92, "altered": 18, "tested": 366, "note": null}, {"cohort": "hcc_inserm_fr_2015", "status": "observed", "frequency": 0.82, "altered": 2, "tested": 243, "note": null}, {"cohort": "hcc_msk_2024", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "EYS", "kind": "SNV / small indel", "gene": "EYS", "cells": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 4.92, "altered": 18, "tested": 366, "note": null}, {"cohort": "hcc_inserm_fr_2015", "status": "observed", "frequency": 2.06, "altered": 5, "tested": 243, "note": null}, {"cohort": "hcc_msk_2024", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "EYS", "kind": "amplification", "gene": "EYS", "cells": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.81, "altered": 14, "tested": 367, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "hcc_inserm_fr_2015", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "No copy-number profile is connected for this cohort."}, {"cohort": "hcc_msk_2024", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 1370, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "DCHS1", "kind": "SNV / small indel", "gene": "DCHS1", "cells": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 4.92, "altered": 18, "tested": 366, "note": null}, {"cohort": "hcc_inserm_fr_2015", "status": "observed", "frequency": 2.88, "altered": 7, "tested": 243, "note": null}, {"cohort": "hcc_msk_2024", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "COL6A6", "kind": "SNV / small indel", "gene": "COL6A6", "cells": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 4.92, "altered": 18, "tested": 366, "note": null}, {"cohort": "hcc_inserm_fr_2015", "status": "observed", "frequency": 1.23, "altered": 3, "tested": 243, "note": null}, {"cohort": "hcc_msk_2024", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "ABCA12", "kind": "SNV / small indel", "gene": "ABCA12", "cells": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 4.92, "altered": 18, "tested": 366, "note": null}, {"cohort": "hcc_inserm_fr_2015", "status": "observed", "frequency": 1.23, "altered": 3, "tested": 243, "note": null}, {"cohort": "hcc_msk_2024", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "PTPRQ", "kind": "SNV / small indel", "gene": "PTPRQ", "cells": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 4.64, "altered": 17, "tested": 366, "note": null}, {"cohort": "hcc_inserm_fr_2015", "status": "observed", "frequency": 2.88, "altered": 7, "tested": 243, "note": null}, {"cohort": "hcc_msk_2024", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "PKHD1", "kind": "SNV / small indel", "gene": "PKHD1", "cells": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 4.64, "altered": 17, "tested": 366, "note": null}, {"cohort": "hcc_inserm_fr_2015", "status": "observed", "frequency": 3.7, "altered": 9, "tested": 243, "note": null}, {"cohort": "hcc_msk_2024", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "PKHD1", "kind": "amplification", "gene": "PKHD1", "cells": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 2.18, "altered": 8, "tested": 367, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "hcc_inserm_fr_2015", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "No copy-number profile is connected for this cohort."}, {"cohort": "hcc_msk_2024", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 1370, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "MYT1L", "kind": "SNV / small indel", "gene": "MYT1L", "cells": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 4.64, "altered": 17, "tested": 366, "note": null}, {"cohort": "hcc_inserm_fr_2015", "status": "observed", "frequency": 1.23, "altered": 3, "tested": 243, "note": null}, {"cohort": "hcc_msk_2024", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "KMT2C", "kind": "SNV / small indel", "gene": "KMT2C", "cells": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 4.64, "altered": 17, "tested": 366, "note": null}, {"cohort": "hcc_inserm_fr_2015", "status": "observed", "frequency": 2.47, "altered": 6, "tested": 243, "note": null}, {"cohort": "hcc_msk_2024", "status": "observed", "frequency": 5.04, "altered": 69, "tested": 1370, "note": null}]}, {"label": "FAT2", "kind": "SNV / small indel", "gene": "FAT2", "cells": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 4.64, "altered": 17, "tested": 366, "note": null}, {"cohort": "hcc_inserm_fr_2015", "status": "observed", "frequency": 2.88, "altered": 7, "tested": 243, "note": null}, {"cohort": "hcc_msk_2024", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "LRRIQ1", "kind": "SNV / small indel", "gene": "LRRIQ1", "cells": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 4.37, "altered": 16, "tested": 366, "note": null}, {"cohort": "hcc_inserm_fr_2015", "status": "observed", "frequency": 2.88, "altered": 7, "tested": 243, "note": null}, {"cohort": "hcc_msk_2024", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "FMN2", "kind": "SNV / small indel", "gene": "FMN2", "cells": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 4.37, "altered": 16, "tested": 366, "note": null}, {"cohort": "hcc_inserm_fr_2015", "status": "observed", "frequency": 1.65, "altered": 4, "tested": 243, "note": null}, {"cohort": "hcc_msk_2024", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "FMN2", "kind": "amplification", "gene": "FMN2", "cells": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 6.27, "altered": 23, "tested": 367, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "hcc_inserm_fr_2015", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "No copy-number profile is connected for this cohort."}, {"cohort": "hcc_msk_2024", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 1370, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "FCGBP", "kind": "SNV / small indel", "gene": "FCGBP", "cells": [{"cohort": "lihc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 4.37, "altered": 16, "tested": 366, "note": null}, {"cohort": "hcc_inserm_fr_2015", "status": "observed", "frequency": 3.29, "altered": 8, "tested": 243, "note": null}, {"cohort": "hcc_msk_2024", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}]}