{"disease": {"name": "Hodgkin lymphoma", "mondo_id": null, "ncit_id": null, "umls_id": null, "oncotree_code": "chl"}, "updated_at": "2026-09-18", "genome_builds": ["hg19"], "cohort_count": 1, "cohort_count_status": "observed", "cohort_count_unit": "cohorts", "evaluable_patients": null, "evaluable_patients_status": "unknown", "evaluable_patients_unit": "patients", "alteration_types": ["SNV", "small indel", "amplification", "deep deletion"], "genes": [{"gene": "TNFRSF8", "alteration_types": ["SNV / small indel"], "altered": 1, "tested": 61, "frequency": 1.64, "cohort_count": 1, "frequency_range": {"min": 1.64, "max": 1.64}, "major_variants": ["R442S (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=chl_sccc_2023", "source_record_id": "chl_sccc_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023), 1/61 patients (1.64%).", "Observed in 1 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "chl_sccc_2023", "cohort_name": "Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023)", "altered": 1, "tested": 61, "frequency": 1.64, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "61/61", "coverage_note": null, "source_id": "chl_sccc_2023", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 5.47, "width": 1.0, "reference": 5.47, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 1, "tested": 61, "frequency": 1.64, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "PDCD1", "alteration_types": ["SNV / small indel"], "altered": 2, "tested": 61, "frequency": 3.28, "cohort_count": 1, "frequency_range": {"min": 3.28, "max": 3.28}, "major_variants": ["C123W (n=1)", "Q99* (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=chl_sccc_2023", "source_record_id": "chl_sccc_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023), 2/61 patients (3.28%).", "Observed in 1 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "chl_sccc_2023", "cohort_name": "Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023)", "altered": 2, "tested": 61, "frequency": 3.28, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "61/61", "coverage_note": null, "source_id": "chl_sccc_2023", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 10.93, "width": 1.0, "reference": 10.93, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 2, "tested": 61, "frequency": 3.28, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "CD274", "alteration_types": [], "altered": 0, "tested": 61, "frequency": 0.0, "cohort_count": 0, "frequency_range": {"min": 0.0, "max": 0.0}, "major_variants": [], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=chl_sccc_2023", "source_record_id": "chl_sccc_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023), 0/61 patients (0.0%).", "Observed in 0 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "chl_sccc_2023", "cohort_name": "Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023)", "altered": 0, "tested": 61, "frequency": 0.0, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "61/61", "coverage_note": null, "source_id": "chl_sccc_2023", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 0.0, "width": 1.0, "reference": 0.0, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 0, "tested": 61, "frequency": 0.0, "is_mutation": true}, "altered_status": "not_observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "not_observed", "frequency_unit": "percent", "cohort_count_status": "not_observed", "cohort_count_unit": "cohorts"}, {"gene": "PDCD1LG2", "alteration_types": ["SNV / small indel"], "altered": 1, "tested": 61, "frequency": 1.64, "cohort_count": 1, "frequency_range": {"min": 1.64, "max": 1.64}, "major_variants": ["H218Qfs*68 (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=chl_sccc_2023", "source_record_id": "chl_sccc_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023), 1/61 patients (1.64%).", "Observed in 1 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "chl_sccc_2023", "cohort_name": "Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023)", "altered": 1, "tested": 61, "frequency": 1.64, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "61/61", "coverage_note": null, "source_id": "chl_sccc_2023", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 5.47, "width": 1.0, "reference": 5.47, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 1, "tested": 61, "frequency": 1.64, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "JAK2", "alteration_types": [], "altered": 0, "tested": 61, "frequency": 0.0, "cohort_count": 0, "frequency_range": {"min": 0.0, "max": 0.0}, "major_variants": [], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=chl_sccc_2023", "source_record_id": "chl_sccc_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023), 0/61 patients (0.0%).", "Observed in 0 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "chl_sccc_2023", "cohort_name": "Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023)", "altered": 0, "tested": 61, "frequency": 0.0, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "61/61", "coverage_note": null, "source_id": "chl_sccc_2023", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 0.0, "width": 1.0, "reference": 0.0, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 0, "tested": 61, "frequency": 0.0, "is_mutation": true}, "altered_status": "not_observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "not_observed", "frequency_unit": "percent", "cohort_count_status": "not_observed", "cohort_count_unit": "cohorts"}, {"gene": "B2M", "alteration_types": ["SNV / small indel"], "altered": 20, "tested": 61, "frequency": 32.79, "cohort_count": 1, "frequency_range": {"min": 32.79, "max": 32.79}, "major_variants": ["M1? (n=8)", "L12P (n=3)", "V9E (n=3)", "L15Ffs*41 (n=3)", "X23_splice (n=2)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=chl_sccc_2023", "source_record_id": "chl_sccc_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023), 20/61 patients (32.79%).", "Observed in 1 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "chl_sccc_2023", "cohort_name": "Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023)", "altered": 20, "tested": 61, "frequency": 32.79, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "61/61", "coverage_note": null, "source_id": "chl_sccc_2023", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 100.0, "width": 1.0, "reference": 100.0, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 20, "tested": 61, "frequency": 32.79, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "SOCS1", "alteration_types": ["SNV / small indel"], "altered": 38, "tested": 61, "frequency": 62.3, "cohort_count": 1, "frequency_range": {"min": 62.3, "max": 62.3}, "major_variants": ["G99V (n=2)", "R104C (n=2)", "Q175* (n=1)", "R127_F130del (n=1)", "A16Qfs*62 (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=chl_sccc_2023", "source_record_id": "chl_sccc_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023), 38/61 patients (62.3%).", "Observed in 1 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "chl_sccc_2023", "cohort_name": "Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023)", "altered": 38, "tested": 61, "frequency": 62.3, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "61/61", "coverage_note": null, "source_id": "chl_sccc_2023", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 100.0, "width": 1.0, "reference": 100.0, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 38, "tested": 61, "frequency": 62.3, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "TNFAIP3", "alteration_types": ["SNV / small indel"], "altered": 22, "tested": 61, "frequency": 36.07, "cohort_count": 1, "frequency_range": {"min": 36.07, "max": 36.07}, "major_variants": ["L626Efs*65 (n=1)", "X99_splice (n=1)", "E366Gfs*19 (n=1)", "C243Y (n=1)", "Q700Hfs*44 (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=chl_sccc_2023", "source_record_id": "chl_sccc_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023), 22/61 patients (36.07%).", "Observed in 1 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "chl_sccc_2023", "cohort_name": "Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023)", "altered": 22, "tested": 61, "frequency": 36.07, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "61/61", "coverage_note": null, "source_id": "chl_sccc_2023", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 100.0, "width": 1.0, "reference": 100.0, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 22, "tested": 61, "frequency": 36.07, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "XPO1", "alteration_types": ["SNV / small indel"], "altered": 5, "tested": 61, "frequency": 8.2, "cohort_count": 1, "frequency_range": {"min": 8.2, "max": 8.2}, "major_variants": ["E571K (n=5)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=chl_sccc_2023", "source_record_id": "chl_sccc_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023), 5/61 patients (8.2%).", "Observed in 1 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "chl_sccc_2023", "cohort_name": "Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023)", "altered": 5, "tested": 61, "frequency": 8.2, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "61/61", "coverage_note": null, "source_id": "chl_sccc_2023", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 27.33, "width": 1.0, "reference": 27.33, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 5, "tested": 61, "frequency": 8.2, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "CIITA", "alteration_types": ["SNV / small indel"], "altered": 3, "tested": 61, "frequency": 4.92, "cohort_count": 1, "frequency_range": {"min": 4.92, "max": 4.92}, "major_variants": ["X18_splice (n=1)", "L694S (n=1)", "L13V (n=1)", "G10E (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=chl_sccc_2023", "source_record_id": "chl_sccc_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023), 3/61 patients (4.92%).", "Observed in 1 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "chl_sccc_2023", "cohort_name": "Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023)", "altered": 3, "tested": 61, "frequency": 4.92, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "61/61", "coverage_note": null, "source_id": "chl_sccc_2023", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 16.4, "width": 1.0, "reference": 16.4, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 3, "tested": 61, "frequency": 4.92, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "REL", "alteration_types": [], "altered": 0, "tested": 61, "frequency": 0.0, "cohort_count": 0, "frequency_range": {"min": 0.0, "max": 0.0}, "major_variants": [], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=chl_sccc_2023", "source_record_id": "chl_sccc_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023), 0/61 patients (0.0%).", "Observed in 0 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "chl_sccc_2023", "cohort_name": "Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023)", "altered": 0, "tested": 61, "frequency": 0.0, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "61/61", "coverage_note": null, "source_id": "chl_sccc_2023", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 0.0, "width": 1.0, "reference": 0.0, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 0, "tested": 61, "frequency": 0.0, "is_mutation": true}, "altered_status": "not_observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "not_observed", "frequency_unit": "percent", "cohort_count_status": "not_observed", "cohort_count_unit": "cohorts"}, {"gene": "MS4A1", "alteration_types": [], "altered": 0, "tested": 61, "frequency": 0.0, "cohort_count": 0, "frequency_range": {"min": 0.0, "max": 0.0}, "major_variants": [], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=chl_sccc_2023", "source_record_id": "chl_sccc_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023), 0/61 patients (0.0%).", "Observed in 0 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "chl_sccc_2023", "cohort_name": "Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023)", "altered": 0, "tested": 61, "frequency": 0.0, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "61/61", "coverage_note": null, "source_id": "chl_sccc_2023", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 0.0, "width": 1.0, "reference": 0.0, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 0, "tested": 61, "frequency": 0.0, "is_mutation": true}, "altered_status": "not_observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "not_observed", "frequency_unit": "percent", "cohort_count_status": "not_observed", "cohort_count_unit": "cohorts"}, {"gene": "ITPKB", "alteration_types": ["SNV / small indel"], "altered": 17, "tested": 61, "frequency": 27.87, "cohort_count": 1, "frequency_range": {"min": 27.87, "max": 27.87}, "major_variants": ["G233R (n=1)", "W509* (n=1)", "S158T (n=1)", "R331* (n=1)", "L350M (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=chl_sccc_2023", "source_record_id": "chl_sccc_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023), 17/61 patients (27.87%).", "Observed in 1 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "chl_sccc_2023", "cohort_name": "Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023)", "altered": 17, "tested": 61, "frequency": 27.87, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "61/61", "coverage_note": null, "source_id": "chl_sccc_2023", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 92.9, "width": 1.0, "reference": 92.9, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 17, "tested": 61, "frequency": 27.87, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "GNA13", "alteration_types": ["SNV / small indel"], "altered": 16, "tested": 61, "frequency": 26.23, "cohort_count": 1, "frequency_range": {"min": 26.23, "max": 26.23}, "major_variants": ["I149K (n=1)", "Y145S (n=1)", "S12Pfs*86 (n=1)", "E33Vfs*71 (n=1)", "S228* (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=chl_sccc_2023", "source_record_id": "chl_sccc_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023), 16/61 patients (26.23%).", "Observed in 1 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "chl_sccc_2023", "cohort_name": "Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023)", "altered": 16, "tested": 61, "frequency": 26.23, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "61/61", "coverage_note": null, "source_id": "chl_sccc_2023", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 87.43, "width": 1.0, "reference": 87.43, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 16, "tested": 61, "frequency": 26.23, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "IGLL5", "alteration_types": ["SNV / small indel"], "altered": 15, "tested": 61, "frequency": 24.59, "cohort_count": 1, "frequency_range": {"min": 24.59, "max": 24.59}, "major_variants": ["P45T (n=1)", "M42K (n=1)", "M33T (n=1)", "V43I (n=1)", "M42I (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=chl_sccc_2023", "source_record_id": "chl_sccc_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023), 15/61 patients (24.59%).", "Observed in 1 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "chl_sccc_2023", "cohort_name": "Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023)", "altered": 15, "tested": 61, "frequency": 24.59, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "61/61", "coverage_note": null, "source_id": "chl_sccc_2023", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 81.97, "width": 1.0, "reference": 81.97, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 15, "tested": 61, "frequency": 24.59, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "STAT6", "alteration_types": ["SNV / small indel"], "altered": 12, "tested": 61, "frequency": 19.67, "cohort_count": 1, "frequency_range": {"min": 19.67, "max": 19.67}, "major_variants": ["N417Y (n=9)", "D419G (n=2)", "D419Y (n=2)", "D419H (n=2)", "G416S (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=chl_sccc_2023", "source_record_id": "chl_sccc_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023), 12/61 patients (19.67%).", "Observed in 1 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "chl_sccc_2023", "cohort_name": "Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023)", "altered": 12, "tested": 61, "frequency": 19.67, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "61/61", "coverage_note": null, "source_id": "chl_sccc_2023", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 65.57, "width": 1.0, "reference": 65.57, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 12, "tested": 61, "frequency": 19.67, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "CENPB", "alteration_types": ["SNV / small indel"], "altered": 12, "tested": 61, "frequency": 19.67, "cohort_count": 1, "frequency_range": {"min": 19.67, "max": 19.67}, "major_variants": ["*18* (n=12)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=chl_sccc_2023", "source_record_id": "chl_sccc_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023), 12/61 patients (19.67%).", "Observed in 1 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "chl_sccc_2023", "cohort_name": "Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023)", "altered": 12, "tested": 61, "frequency": 19.67, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "61/61", "coverage_note": null, "source_id": "chl_sccc_2023", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 65.57, "width": 1.0, "reference": 65.57, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 12, "tested": 61, "frequency": 19.67, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "FAM230A", "alteration_types": ["SNV / small indel"], "altered": 11, "tested": 61, "frequency": 18.03, "cohort_count": 1, "frequency_range": {"min": 18.03, "max": 18.03}, "major_variants": ["V472I (n=1)", "S667L (n=1)", "D377H (n=1)", "T631S (n=1)", "Q362H (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=chl_sccc_2023", "source_record_id": "chl_sccc_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023), 11/61 patients (18.03%).", "Observed in 1 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "chl_sccc_2023", "cohort_name": "Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023)", "altered": 11, "tested": 61, "frequency": 18.03, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "61/61", "coverage_note": null, "source_id": "chl_sccc_2023", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 60.1, "width": 1.0, "reference": 60.1, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 11, "tested": 61, "frequency": 18.03, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "CSF2RB", "alteration_types": ["SNV / small indel"], "altered": 11, "tested": 61, "frequency": 18.03, "cohort_count": 1, "frequency_range": {"min": 18.03, "max": 18.03}, "major_variants": ["E788* (n=4)", "Q853* (n=1)", "Q809* (n=1)", "L825Ffs*7 (n=1)", "L825F (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=chl_sccc_2023", "source_record_id": "chl_sccc_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023), 11/61 patients (18.03%).", "Observed in 1 of 1 cohorts; 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not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=chl_sccc_2023", "source_record_id": "chl_sccc_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023), 5/61 patients (8.2%).", "Observed in 1 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "chl_sccc_2023", "cohort_name": "Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023)", "altered": 5, "tested": 61, "frequency": 8.2, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "61/61", "coverage_note": null, "source_id": "chl_sccc_2023", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 27.33, "width": 1.0, "reference": 27.33, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 5, "tested": 61, "frequency": 8.2, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "DTX1", "alteration_types": ["SNV / small indel"], "altered": 5, "tested": 61, "frequency": 8.2, "cohort_count": 1, "frequency_range": {"min": 8.2, "max": 8.2}, "major_variants": ["H47L (n=1)", "E110Q (n=1)", "R94H (n=1)", "V25A (n=1)", "P19L (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=chl_sccc_2023", "source_record_id": "chl_sccc_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023), 5/61 patients (8.2%).", "Observed in 1 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "chl_sccc_2023", "cohort_name": "Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023)", "altered": 5, "tested": 61, "frequency": 8.2, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "61/61", "coverage_note": null, "source_id": "chl_sccc_2023", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 27.33, "width": 1.0, "reference": 27.33, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 5, "tested": 61, "frequency": 8.2, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "CFAP157", "alteration_types": ["SNV / small indel"], "altered": 5, "tested": 61, "frequency": 8.2, "cohort_count": 1, "frequency_range": {"min": 8.2, "max": 8.2}, "major_variants": ["Q122H (n=3)", "E120V (n=3)", "V126L (n=2)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=chl_sccc_2023", "source_record_id": "chl_sccc_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023), 5/61 patients (8.2%).", "Observed in 1 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "chl_sccc_2023", "cohort_name": "Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023)", "altered": 5, "tested": 61, "frequency": 8.2, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "61/61", "coverage_note": null, "source_id": "chl_sccc_2023", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 27.33, "width": 1.0, "reference": 27.33, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 5, "tested": 61, "frequency": 8.2, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "CCDC138", "alteration_types": ["SNV / small indel"], "altered": 5, "tested": 61, "frequency": 8.2, "cohort_count": 1, "frequency_range": {"min": 8.2, "max": 8.2}, "major_variants": ["S473A (n=4)", "H472N (n=3)", "I187M (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=chl_sccc_2023", "source_record_id": "chl_sccc_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023), 5/61 patients (8.2%).", "Observed in 1 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "chl_sccc_2023", "cohort_name": "Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023)", "altered": 5, "tested": 61, "frequency": 8.2, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "61/61", "coverage_note": null, "source_id": "chl_sccc_2023", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 27.33, "width": 1.0, "reference": 27.33, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 5, "tested": 61, "frequency": 8.2, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}], "variants": [], "genomic_events": [], "modality_summary": [{"modality": "SNV / small indel", "available_cohorts": 1, "total_cohorts": 1}, {"modality": "Copy number (discrete)", "available_cohorts": 0, "total_cohorts": 1}, {"modality": "Structural variant (present, not read)", "available_cohorts": 0, "total_cohorts": 1}], "chromosome_summary": [], "cohorts": [{"name": "Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023)", "source": "cBioPortal", "accession": "chl_sccc_2023", "patients": {"value": 61, "status": "observed", "unit": "patients"}, "samples": {"value": 61, "status": "observed", "unit": "samples"}, "disease_subtype": "Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023)", "assay_type": "exome or genome", "sequencing_method": "WES (61)", "genome_build": "hg19", "alteration_types_available": ["SNV", "small indel"], "genes_assayed": "all coding genes", "primary_or_metastatic": null, "age_group": null, "retrieved_at": "2026-09-18", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "source_record_id": "chl_sccc_2023", "is_demo": false, "assay_coverage": {"patients_with_calls": 61, "patients_in_roster": 61, "frequencies_computed": true, "samples_sequenced": 61, "samples_in_study": 61, "hypermutated_patients": 0, "median_mutations_per_sample": 111, "reason": null}}], "sources": [{"source_name": "cBioPortal · Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023)", "source_url": "https://www.cbioportal.org/study/summary?id=chl_sccc_2023", "source_record_id": "chl_sccc_2023", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "limitations": ["A cBioPortal public-API snapshot retrieved 2026-09-18; the page does not refresh source data at request time.", "Counts are patients with at least one non-silent call in the study's sequenced sample list; silent, intronic and UTR calls are excluded.", "For targeted-panel cohorts each gene divides by the patients whose panel carried it; a gene absent from the panel is shown as not assayed, not as zero.", "Copy-number rows use discrete calls (2 = high-level amplification, −2 = deep deletion) against the cohort's copy-number sample list, which is a different roster from the sequenced one.", "Cohorts are not pooled. Cross-study patient overlap has not been checked and no disease-wide frequency is reported.", "Structural variants and fusions are not read in this snapshot even where the study carries a profile; germline variants, mutational signatures, TMB and MSI are not reported.", "The gene set is the briefing's curated targets plus the reference cohort's most frequently mutated genes; it is not genome-wide."], "answer_block": ["In Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023) (61 sequenced patients, exome or genome), the most frequently altered of the 48 genes shown are SOCS1 62.3%, TNFAIP3 36.07%, B2M 32.79%, ITPKB 27.87%, GNA13 26.23%. Each figure divides by the patients on whom that gene could be called.", "Of the briefing's 12 curated targets, 6 are altered in under 2% of this cohort (TNFRSF8, CD274, PDCD1LG2, JAK2, REL, MS4A1): targets by expression, dependency or drug label, not by mutation. Frequency is not targetability, in either direction.", "1 cohorts are shown and none are pooled; overlap between them has not been checked and there is no disease-wide percentage."], "key_findings": [{"finding": "SOCS1 is mutated in 38 of 61 patients in Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023).", "numerator": 38, "denominator": 61, "frequency": 62.3, "cohorts": 1, "evidence_confidence": "moderate", "source": "chl_sccc_2023", "retrieved_at": "2026-09-18"}, {"finding": "TNFAIP3 is mutated in 22 of 61 patients in Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023).", "numerator": 22, "denominator": 61, "frequency": 36.07, "cohorts": 1, "evidence_confidence": "moderate", "source": "chl_sccc_2023", "retrieved_at": "2026-09-18"}, {"finding": "B2M is mutated in 20 of 61 patients in Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023).", "numerator": 20, "denominator": 61, "frequency": 32.79, "cohorts": 1, "evidence_confidence": "moderate", "source": "chl_sccc_2023", "retrieved_at": "2026-09-18"}], "research_gaps": [{"kind": "Structural variants", "text": "Read the structural-variant profiles the studies carry; fusions are the defining event in several of these diseases."}, {"kind": "Context", "text": "Stage, subtype, age and treatment line are not attached to any count; the cohorts differ on all four."}, {"kind": "Interpretation", "text": "Activating versus inactivating, actionable versus not, and evidence level are not inferred here; the briefing's target table carries the drug and trial facts."}], "observations": [], "data_status": "PUBLIC SOURCE SNAPSHOT", "is_demo": false, "reference_cohort": "chl_sccc_2023", "region_events": [], "matrix": [{"label": "TNFRSF8", "kind": "SNV / small indel", "gene": "TNFRSF8", "cells": [{"cohort": "chl_sccc_2023", "status": "observed", "frequency": 1.64, "altered": 1, "tested": 61, "note": null}]}, {"label": "PDCD1", "kind": "SNV / small indel", "gene": "PDCD1", "cells": [{"cohort": "chl_sccc_2023", "status": "observed", "frequency": 3.28, "altered": 2, "tested": 61, "note": null}]}, {"label": "CD274", "kind": "SNV / small indel", "gene": "CD274", "cells": [{"cohort": "chl_sccc_2023", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 61, "note": null}]}, {"label": "PDCD1LG2", "kind": "SNV / small indel", "gene": "PDCD1LG2", "cells": [{"cohort": "chl_sccc_2023", "status": "observed", "frequency": 1.64, "altered": 1, "tested": 61, "note": null}]}, {"label": "JAK2", "kind": "SNV / small indel", "gene": "JAK2", "cells": [{"cohort": "chl_sccc_2023", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 61, "note": null}]}, {"label": "B2M", "kind": "SNV / small indel", "gene": "B2M", "cells": [{"cohort": "chl_sccc_2023", "status": "observed", "frequency": 32.79, "altered": 20, "tested": 61, "note": null}]}, {"label": "SOCS1", "kind": "SNV / small indel", "gene": "SOCS1", "cells": [{"cohort": "chl_sccc_2023", "status": "observed", "frequency": 62.3, "altered": 38, "tested": 61, "note": null}]}, {"label": "TNFAIP3", "kind": "SNV / small indel", "gene": "TNFAIP3", "cells": [{"cohort": "chl_sccc_2023", "status": "observed", "frequency": 36.07, "altered": 22, "tested": 61, "note": null}]}, {"label": "XPO1", "kind": "SNV / small indel", "gene": "XPO1", "cells": [{"cohort": "chl_sccc_2023", "status": "observed", "frequency": 8.2, "altered": 5, "tested": 61, "note": null}]}, {"label": "CIITA", "kind": "SNV / small indel", "gene": "CIITA", "cells": [{"cohort": "chl_sccc_2023", "status": "observed", "frequency": 4.92, "altered": 3, "tested": 61, "note": null}]}, {"label": "REL", "kind": "SNV / small indel", "gene": "REL", "cells": [{"cohort": "chl_sccc_2023", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 61, "note": null}]}, {"label": "MS4A1", "kind": "SNV / small indel", "gene": "MS4A1", "cells": [{"cohort": "chl_sccc_2023", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 61, "note": null}]}, {"label": "ITPKB", "kind": "SNV / small indel", "gene": "ITPKB", "cells": [{"cohort": "chl_sccc_2023", "status": "observed", "frequency": 27.87, "altered": 17, "tested": 61, "note": null}]}, {"label": "GNA13", "kind": "SNV / small indel", "gene": "GNA13", "cells": [{"cohort": "chl_sccc_2023", "status": "observed", "frequency": 26.23, "altered": 16, "tested": 61, "note": null}]}, {"label": "IGLL5", "kind": "SNV / small indel", "gene": "IGLL5", "cells": [{"cohort": "chl_sccc_2023", "status": "observed", "frequency": 24.59, "altered": 15, "tested": 61, "note": null}]}, {"label": "STAT6", "kind": "SNV / small indel", "gene": "STAT6", "cells": [{"cohort": "chl_sccc_2023", "status": "observed", "frequency": 19.67, "altered": 12, "tested": 61, "note": null}]}, {"label": "CENPB", "kind": "SNV / small indel", "gene": "CENPB", "cells": [{"cohort": "chl_sccc_2023", "status": "observed", "frequency": 19.67, "altered": 12, "tested": 61, "note": null}]}, {"label": "FAM230A", "kind": "SNV / small indel", "gene": "FAM230A", "cells": [{"cohort": "chl_sccc_2023", "status": "observed", "frequency": 18.03, "altered": 11, "tested": 61, "note": null}]}, {"label": "CSF2RB", "kind": "SNV / small indel", "gene": "CSF2RB", "cells": [{"cohort": "chl_sccc_2023", "status": "observed", "frequency": 18.03, "altered": 11, "tested": 61, "note": null}]}, {"label": "BCL7A", "kind": "SNV / small indel", "gene": "BCL7A", "cells": [{"cohort": "chl_sccc_2023", "status": "observed", "frequency": 18.03, "altered": 11, "tested": 61, "note": null}]}, {"label": "NFKB2", "kind": "SNV / small indel", "gene": "NFKB2", "cells": [{"cohort": "chl_sccc_2023", "status": "observed", "frequency": 13.11, "altered": 8, "tested": 61, "note": null}]}, {"label": "MFHAS1", "kind": "SNV / small indel", "gene": "MFHAS1", "cells": [{"cohort": "chl_sccc_2023", "status": "observed", "frequency": 13.11, "altered": 8, "tested": 61, "note": null}]}, {"label": "KMT2D", "kind": "SNV / small indel", "gene": "KMT2D", "cells": [{"cohort": "chl_sccc_2023", "status": "observed", "frequency": 13.11, "altered": 8, "tested": 61, "note": null}]}, {"label": "H1-4", "kind": "SNV / small indel", "gene": "H1-4", "cells": [{"cohort": "chl_sccc_2023", "status": "observed", "frequency": 13.11, "altered": 8, "tested": 61, "note": null}]}, {"label": "ZFP36L1", "kind": "SNV / small indel", "gene": "ZFP36L1", "cells": [{"cohort": "chl_sccc_2023", "status": "observed", "frequency": 11.48, "altered": 7, "tested": 61, "note": null}]}, {"label": "SDK2", "kind": "SNV / small indel", "gene": "SDK2", "cells": [{"cohort": "chl_sccc_2023", "status": "observed", "frequency": 11.48, "altered": 7, "tested": 61, "note": null}]}, {"label": "NFKBIE", "kind": "SNV / small indel", "gene": "NFKBIE", "cells": [{"cohort": "chl_sccc_2023", "status": "observed", "frequency": 11.48, "altered": 7, "tested": 61, "note": null}]}, {"label": "LRRN3", "kind": "SNV / small indel", "gene": "LRRN3", "cells": [{"cohort": "chl_sccc_2023", "status": "observed", "frequency": 11.48, "altered": 7, "tested": 61, "note": null}]}, {"label": "ACTB", "kind": "SNV / small indel", "gene": "ACTB", "cells": [{"cohort": "chl_sccc_2023", "status": "observed", "frequency": 11.48, "altered": 7, "tested": 61, "note": null}]}, {"label": "RAB19", "kind": "SNV / small indel", "gene": "RAB19", "cells": [{"cohort": "chl_sccc_2023", "status": "observed", "frequency": 9.84, "altered": 6, "tested": 61, "note": null}]}, {"label": "PCDHGB6", "kind": "SNV / small indel", "gene": "PCDHGB6", "cells": [{"cohort": "chl_sccc_2023", "status": "observed", "frequency": 9.84, "altered": 6, "tested": 61, "note": null}]}, {"label": "P2RY8", "kind": "SNV / small indel", "gene": "P2RY8", "cells": [{"cohort": "chl_sccc_2023", "status": "observed", "frequency": 9.84, "altered": 6, "tested": 61, "note": null}]}, {"label": "LTBP3", "kind": "SNV / small indel", "gene": "LTBP3", "cells": [{"cohort": "chl_sccc_2023", "status": "observed", "frequency": 9.84, "altered": 6, "tested": 61, "note": null}]}, {"label": "LTB", "kind": "SNV / small indel", "gene": "LTB", "cells": [{"cohort": "chl_sccc_2023", "status": "observed", "frequency": 9.84, "altered": 6, "tested": 61, "note": null}]}, {"label": "EGR1", "kind": "SNV / small indel", "gene": "EGR1", "cells": [{"cohort": "chl_sccc_2023", "status": "observed", "frequency": 9.84, "altered": 6, "tested": 61, "note": null}]}, {"label": "BTG1", "kind": "SNV / small indel", "gene": "BTG1", "cells": [{"cohort": "chl_sccc_2023", "status": "observed", "frequency": 9.84, "altered": 6, "tested": 61, "note": null}]}, {"label": "TRIOBP", "kind": "SNV / small indel", "gene": "TRIOBP", "cells": [{"cohort": "chl_sccc_2023", "status": "observed", "frequency": 8.2, "altered": 5, "tested": 61, "note": null}]}, {"label": "TP53", "kind": "SNV / small indel", "gene": "TP53", "cells": [{"cohort": "chl_sccc_2023", "status": "observed", "frequency": 8.2, "altered": 5, "tested": 61, "note": null}]}, {"label": "TINF2", "kind": "SNV / small indel", "gene": "TINF2", "cells": [{"cohort": "chl_sccc_2023", "status": "observed", "frequency": 8.2, "altered": 5, "tested": 61, "note": null}]}, {"label": "PTPN1", "kind": "SNV / small indel", "gene": "PTPN1", "cells": [{"cohort": "chl_sccc_2023", "status": "observed", "frequency": 8.2, "altered": 5, "tested": 61, "note": null}]}, {"label": "POLE", "kind": "SNV / small indel", "gene": "POLE", "cells": [{"cohort": "chl_sccc_2023", "status": "observed", "frequency": 8.2, "altered": 5, "tested": 61, "note": null}]}, {"label": "FSIP2", "kind": "SNV / small indel", "gene": "FSIP2", "cells": [{"cohort": "chl_sccc_2023", "status": "observed", "frequency": 8.2, "altered": 5, "tested": 61, "note": null}]}, {"label": "FAT1", "kind": "SNV / small indel", "gene": "FAT1", "cells": [{"cohort": "chl_sccc_2023", "status": "observed", "frequency": 8.2, "altered": 5, "tested": 61, "note": null}]}, {"label": "EEF1A1", "kind": "SNV / small indel", "gene": "EEF1A1", "cells": [{"cohort": 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