{
 "disease": "lower-grade-glioma",
 "label": "Lower-grade glioma",
 "url": "https://usebiotransfer.org/disease/lower-grade-glioma/",
 "built": "2026-09-12",
 "facts_hash": {
  "answers": "33d5876d6df3",
  "targets": "fa89c70577eb"
 },
 "sources": {
  "targets": "Open Targets Platform GraphQL API v4",
  "trials": "ClinicalTrials.gov API v2"
 },
 "retrieved": {
  "targets": "2026-09-12",
  "trials": "2026-09-12"
 },
 "query": {
  "endpoint": "https://clinicaltrials.gov/api/v2/studies",
  "shape": "query.cond=<disease>&query.intr=<term>&pageSize=200",
  "active_statuses": [
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   "ENROLLING_BY_INVITATION",
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   "RECRUITING"
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  "study_types": "interventional counted in headline; observational reported separately",
  "known_floor": "trials naming an antigen only by product code are not retrieved by an intervention-name search"
 },
 "targets": [
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    "OLUTASIDENIB",
    "VORASIDENIB"
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   "approved_for": {
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    "OLUTASIDENIB": [
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     "acute myeloid leukemia"
    ],
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    "NINTEDANIB": [
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     "interstitial lung disease",
     "systemic sclerosis",
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    "NINTEDANIB ESYLATE": [
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     "non-small cell lung carcinoma",
     "Interstitial pneumonitis"
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    "OLARATUMAB": [
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     "soft tissue sarcoma"
    ],
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     "sarcoma"
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     "metastatic colorectal cancer",
     "colorectal neoplasm"
    ],
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 ],
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      "nct": "NCT04267978",
      "title": "Study of Recombinant Human Endostatin Combined with Temozolomide and Irinotecan in Recurrent Gliomas",
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      "last_update": "2024-10-15",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04623931",
      "title": "Chemotherapy and Radiation Therapy for the Treatment of IDH Wildtype Gliomas or Non-histological (Molecular) Glioblastomas",
      "status": "RECRUITING",
      "last_update": "2026-07-16",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT03763422",
      "title": "Trial in Low Grade Glioma Patients: Wait or Treat",
      "status": "TERMINATED",
      "last_update": "2022-02-01",
      "phase": "PHASE3",
      "study_type": "INTERVENTIONAL"
     }
    ],
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    "synonyms_searched": [
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   "PDGFR": {
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    "cell_therapy": {
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     "trials": []
    },
    "synonyms_searched": [
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     "dasatinib"
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   },
   "mTOR": {
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    "cell_therapy": {
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     "trials": []
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    "synonyms_searched": [
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   }
  },
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     {
      "nct": "NCT05609994",
      "title": "ViCToRy: Vorasidenib in Combination With Tumor Specific Peptide Vaccine for Recurrent IDH1 Mutant Lower Grade Gliomas",
      "status": "RECRUITING",
      "last_update": "2026-08-24",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     }
    ]
   }
  }
 }
}