{"disease": {"name": "Lower-grade glioma", "mondo_id": null, "ncit_id": null, "umls_id": null, "oncotree_code": "difg"}, "updated_at": "2026-09-18", "genome_builds": ["hg19"], "cohort_count": 2, "cohort_count_status": "observed", "cohort_count_unit": "cohorts", "evaluable_patients": null, "evaluable_patients_status": "unknown", "evaluable_patients_unit": "patients", "alteration_types": ["SNV", "small indel", "amplification", "deep deletion"], "genes": [{"gene": "IDH1", "alteration_types": ["SNV / small indel", "deep deletion"], "altered": 395, "tested": 514, "frequency": 76.85, "cohort_count": 2, "frequency_range": {"min": 34.09, "max": 76.85}, "major_variants": ["R132H (n=358)", "R132C (n=17)", "R132G (n=11)", "R132S (n=9)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lgg_tcga_pan_can_atlas_2018", "source_record_id": "lgg_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Glioma (MSK, Clin Cancer Res 2019)", "source_url": "https://www.cbioportal.org/study/summary?id=glioma_mskcc_2019", "source_record_id": "glioma_mskcc_2019", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Brain Lower Grade Glioma (TCGA, PanCancer Atlas), 395/514 patients (76.85%).", "Without the 4 hypermutated patients: 393/510 (77.06%).", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "cohort_name": "Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "altered": 395, "tested": 514, "frequency": 76.85, "frequency_excl_hypermutated": 77.06, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "514/514", "coverage_note": null, "source_id": "lgg_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "glioma_mskcc_2019", "cohort_name": "Glioma (MSK, Clin Cancer Res 2019)", "altered": 315, "tested": 924, "frequency": 34.09, "frequency_excl_hypermutated": 34.03, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "1004/1004", "coverage_note": null, "source_id": "glioma_mskcc_2019", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 100.0, "width": 1.0, "reference": 100.0, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 395, "tested": 514, "frequency": 76.85, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "IDH2", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 21, "tested": 514, "frequency": 4.09, "cohort_count": 2, "frequency_range": {"min": 2.49, "max": 4.09}, "major_variants": ["R172K (n=12)", "R172M (n=3)", "R172G (n=2)", "R172W (n=2)", "R172S (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lgg_tcga_pan_can_atlas_2018", "source_record_id": "lgg_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Glioma (MSK, Clin Cancer Res 2019)", "source_url": "https://www.cbioportal.org/study/summary?id=glioma_mskcc_2019", "source_record_id": "glioma_mskcc_2019", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Brain Lower Grade Glioma (TCGA, PanCancer Atlas), 21/514 patients (4.09%).", "Without the 4 hypermutated patients: 21/510 (4.12%).", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "cohort_name": "Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "altered": 21, "tested": 514, "frequency": 4.09, "frequency_excl_hypermutated": 4.12, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "514/514", "coverage_note": null, "source_id": "lgg_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "glioma_mskcc_2019", "cohort_name": "Glioma (MSK, Clin Cancer Res 2019)", "altered": 23, "tested": 924, "frequency": 2.49, "frequency_excl_hypermutated": 2.09, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "1004/1004", "coverage_note": null, "source_id": "glioma_mskcc_2019", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 8.3, "width": 5.33, "reference": 13.63, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 21, "tested": 514, "frequency": 4.09, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "TP53", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 248, "tested": 514, "frequency": 48.25, "cohort_count": 2, "frequency_range": {"min": 40.58, "max": 48.25}, "major_variants": ["R273C (n=54)", "R273H (n=11)", "Y220C (n=10)", "R175H (n=8)", "R248Q (n=8)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lgg_tcga_pan_can_atlas_2018", "source_record_id": "lgg_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Glioma (MSK, Clin Cancer Res 2019)", "source_url": "https://www.cbioportal.org/study/summary?id=glioma_mskcc_2019", "source_record_id": "glioma_mskcc_2019", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Brain Lower Grade Glioma (TCGA, PanCancer Atlas), 248/514 patients (48.25%).", "Without the 4 hypermutated patients: 245/510 (48.04%).", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "cohort_name": "Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "altered": 248, "tested": 514, "frequency": 48.25, "frequency_excl_hypermutated": 48.04, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "514/514", "coverage_note": null, "source_id": "lgg_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "glioma_mskcc_2019", "cohort_name": "Glioma (MSK, Clin Cancer Res 2019)", "altered": 375, "tested": 924, "frequency": 40.58, "frequency_excl_hypermutated": 39.85, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "1004/1004", "coverage_note": null, "source_id": "glioma_mskcc_2019", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 100.0, "width": 1.0, "reference": 100.0, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 248, "tested": 514, "frequency": 48.25, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "ATRX", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 193, "tested": 514, "frequency": 37.55, "cohort_count": 2, "frequency_range": {"min": 22.08, "max": 37.55}, "major_variants": ["R1426* (n=6)", "F2113Sfs*9 (n=5)", "L359Tfs*3 (n=3)", "S2094* (n=2)", "E886Lfs*18 (n=2)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lgg_tcga_pan_can_atlas_2018", "source_record_id": "lgg_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Glioma (MSK, Clin Cancer Res 2019)", "source_url": "https://www.cbioportal.org/study/summary?id=glioma_mskcc_2019", "source_record_id": "glioma_mskcc_2019", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Brain Lower Grade Glioma (TCGA, PanCancer Atlas), 193/514 patients (37.55%).", "Without the 4 hypermutated patients: 191/510 (37.45%).", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "cohort_name": "Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "altered": 193, "tested": 514, "frequency": 37.55, "frequency_excl_hypermutated": 37.45, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "514/514", "coverage_note": null, "source_id": "lgg_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "glioma_mskcc_2019", "cohort_name": "Glioma (MSK, Clin Cancer Res 2019)", "altered": 204, "tested": 924, "frequency": 22.08, "frequency_excl_hypermutated": 21.51, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "1004/1004", "coverage_note": null, "source_id": "glioma_mskcc_2019", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 73.6, "width": 26.4, "reference": 100.0, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 193, "tested": 514, "frequency": 37.55, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "CIC", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 108, "tested": 514, "frequency": 21.01, "cohort_count": 2, "frequency_range": {"min": 13.1, "max": 21.01}, "major_variants": ["R215W (n=10)", "R202W (n=5)", "R201W (n=5)", "R1515C (n=4)", "R215Q (n=4)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lgg_tcga_pan_can_atlas_2018", "source_record_id": "lgg_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Glioma (MSK, Clin Cancer Res 2019)", "source_url": "https://www.cbioportal.org/study/summary?id=glioma_mskcc_2019", "source_record_id": "glioma_mskcc_2019", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Brain Lower Grade Glioma (TCGA, PanCancer Atlas), 108/514 patients (21.01%).", "Without the 4 hypermutated patients: 106/510 (20.78%).", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "cohort_name": "Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "altered": 108, "tested": 514, "frequency": 21.01, "frequency_excl_hypermutated": 20.78, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "514/514", "coverage_note": null, "source_id": "lgg_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "glioma_mskcc_2019", "cohort_name": "Glioma (MSK, Clin Cancer Res 2019)", "altered": 121, "tested": 924, "frequency": 13.1, "frequency_excl_hypermutated": 12.18, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "1004/1004", "coverage_note": null, "source_id": "glioma_mskcc_2019", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 43.67, "width": 26.36, "reference": 70.03, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 108, "tested": 514, "frequency": 21.01, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "FUBP1", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 46, "tested": 514, "frequency": 8.95, "cohort_count": 2, "frequency_range": {"min": 5.02, "max": 8.95}, "major_variants": ["X83_splice (n=3)", "I443Rfs*47 (n=3)", "X314_splice (n=2)", "G182* (n=1)", "W537* (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lgg_tcga_pan_can_atlas_2018", "source_record_id": "lgg_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Glioma (MSK, Clin Cancer Res 2019)", "source_url": "https://www.cbioportal.org/study/summary?id=glioma_mskcc_2019", "source_record_id": "glioma_mskcc_2019", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Brain Lower Grade Glioma (TCGA, PanCancer Atlas), 46/514 patients (8.95%).", "Without the 4 hypermutated patients: 46/510 (9.02%).", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "cohort_name": "Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "altered": 46, "tested": 514, "frequency": 8.95, "frequency_excl_hypermutated": 9.02, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "514/514", "coverage_note": null, "source_id": "lgg_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "glioma_mskcc_2019", "cohort_name": "Glioma (MSK, Clin Cancer Res 2019)", "altered": 41, "tested": 816, "frequency": 5.02, "frequency_excl_hypermutated": 4.61, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "1004/1004", "coverage_note": null, "source_id": "glioma_mskcc_2019", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 16.73, "width": 13.1, "reference": 29.83, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 46, "tested": 514, "frequency": 8.95, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "CDKN2A", "alteration_types": ["SNV / small indel", "deep deletion"], "altered": 3, "tested": 514, "frequency": 0.58, "cohort_count": 2, "frequency_range": {"min": 0.58, "max": 1.95}, "major_variants": ["P48R (n=1)", "R107H (n=1)", "W110* (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lgg_tcga_pan_can_atlas_2018", "source_record_id": "lgg_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Glioma (MSK, Clin Cancer Res 2019)", "source_url": "https://www.cbioportal.org/study/summary?id=glioma_mskcc_2019", "source_record_id": "glioma_mskcc_2019", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Brain Lower Grade Glioma (TCGA, PanCancer Atlas), 3/514 patients (0.58%).", "Without the 4 hypermutated patients: 2/510 (0.39%).", "Largest alteration is deep deletion: 55/511 (10.76%) in the reference cohort's copy-number profile.", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "cohort_name": "Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "altered": 3, "tested": 514, "frequency": 0.58, "frequency_excl_hypermutated": 0.39, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "514/514", "coverage_note": null, "source_id": "lgg_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "glioma_mskcc_2019", "cohort_name": "Glioma (MSK, Clin Cancer Res 2019)", "altered": 18, "tested": 924, "frequency": 1.95, "frequency_excl_hypermutated": 1.65, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "1004/1004", "coverage_note": null, "source_id": "glioma_mskcc_2019", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 35.87, "width": 1.0, "reference": 35.87, "scale_max": 30.0}, "headline_alteration": {"kind": "deep deletion", "altered": 55, "tested": 511, "frequency": 10.76, "is_mutation": false}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "TERT", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 2, "tested": 514, "frequency": 0.39, "cohort_count": 2, "frequency_range": {"min": 0.39, "max": 2.45}, "major_variants": ["V251I (n=1)", "R858W (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lgg_tcga_pan_can_atlas_2018", "source_record_id": "lgg_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Glioma (MSK, Clin Cancer Res 2019)", "source_url": "https://www.cbioportal.org/study/summary?id=glioma_mskcc_2019", "source_record_id": "glioma_mskcc_2019", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Brain Lower Grade Glioma (TCGA, PanCancer Atlas), 2/514 patients (0.39%).", "Without the 4 hypermutated patients: 2/510 (0.39%).", "Largest alteration is amplification: 3/511 (0.59%) in the reference cohort's copy-number profile.", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "cohort_name": "Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "altered": 2, "tested": 514, "frequency": 0.39, "frequency_excl_hypermutated": 0.39, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "514/514", "coverage_note": null, "source_id": "lgg_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "glioma_mskcc_2019", "cohort_name": "Glioma (MSK, Clin Cancer Res 2019)", "altered": 20, "tested": 816, "frequency": 2.45, "frequency_excl_hypermutated": 1.74, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "1004/1004", "coverage_note": null, "source_id": "glioma_mskcc_2019", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 1.97, "width": 1.0, "reference": 1.97, "scale_max": 30.0}, "headline_alteration": {"kind": "amplification", "altered": 3, "tested": 511, "frequency": 0.59, "is_mutation": false}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "PIK3CA", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 42, "tested": 514, "frequency": 8.17, "cohort_count": 2, "frequency_range": {"min": 8.17, "max": 11.69}, "major_variants": ["G118D (n=4)", "E110del (n=4)", "H1047R (n=4)", "E453K (n=3)", "E453del (n=3)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lgg_tcga_pan_can_atlas_2018", "source_record_id": "lgg_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Glioma (MSK, Clin Cancer Res 2019)", "source_url": "https://www.cbioportal.org/study/summary?id=glioma_mskcc_2019", "source_record_id": "glioma_mskcc_2019", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Brain Lower Grade Glioma (TCGA, PanCancer Atlas), 42/514 patients (8.17%).", "Without the 4 hypermutated patients: 40/510 (7.84%).", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "cohort_name": "Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "altered": 42, "tested": 514, "frequency": 8.17, "frequency_excl_hypermutated": 7.84, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "514/514", "coverage_note": null, "source_id": "lgg_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "glioma_mskcc_2019", "cohort_name": "Glioma (MSK, Clin Cancer Res 2019)", "altered": 108, "tested": 924, "frequency": 11.69, "frequency_excl_hypermutated": 11.09, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "1004/1004", "coverage_note": null, "source_id": "glioma_mskcc_2019", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 27.23, "width": 11.74, "reference": 27.23, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 42, "tested": 514, "frequency": 8.17, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "NOTCH1", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 38, "tested": 514, "frequency": 7.39, "cohort_count": 2, "frequency_range": {"min": 7.25, "max": 7.39}, "major_variants": ["F357del (n=7)", "D338del (n=2)", "R448L (n=2)", "N454del (n=2)", "X481_splice (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lgg_tcga_pan_can_atlas_2018", "source_record_id": "lgg_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Glioma (MSK, Clin Cancer Res 2019)", "source_url": "https://www.cbioportal.org/study/summary?id=glioma_mskcc_2019", "source_record_id": "glioma_mskcc_2019", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Brain Lower Grade Glioma (TCGA, PanCancer Atlas), 38/514 patients (7.39%).", "Without the 4 hypermutated patients: 36/510 (7.06%).", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "cohort_name": "Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "altered": 38, "tested": 514, "frequency": 7.39, "frequency_excl_hypermutated": 7.06, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "514/514", "coverage_note": null, "source_id": "lgg_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "glioma_mskcc_2019", "cohort_name": "Glioma (MSK, Clin Cancer Res 2019)", "altered": 67, "tested": 924, "frequency": 7.25, "frequency_excl_hypermutated": 6.15, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "1004/1004", "coverage_note": null, "source_id": "glioma_mskcc_2019", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 24.17, "width": 1.0, "reference": 24.63, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 38, "tested": 514, "frequency": 7.39, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "MGMT", "alteration_types": ["amplification", "deep deletion"], "altered": 0, "tested": 514, "frequency": 0.0, "cohort_count": 0, "frequency_range": {"min": 0.0, "max": 0.0}, "major_variants": [], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lgg_tcga_pan_can_atlas_2018", "source_record_id": "lgg_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Glioma (MSK, Clin Cancer Res 2019)", "source_url": "https://www.cbioportal.org/study/summary?id=glioma_mskcc_2019", "source_record_id": "glioma_mskcc_2019", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Brain Lower Grade Glioma (TCGA, PanCancer Atlas), 0/514 patients (0.0%).", "Without the 4 hypermutated patients: 0/510 (0.0%).", "Largest alteration is deep deletion: 10/511 (1.96%) in the reference cohort's copy-number profile.", "Observed in 0 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "cohort_name": "Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "altered": 0, "tested": 514, "frequency": 0.0, "frequency_excl_hypermutated": 0.0, "counting_unit": "patients", "status": "not_observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "514/514", "coverage_note": null, "source_id": "lgg_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "glioma_mskcc_2019", "cohort_name": "Glioma (MSK, Clin Cancer Res 2019)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "1004/1004", "coverage_note": null, "source_id": "glioma_mskcc_2019", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 6.53, "width": 1.0, "reference": 6.53, "scale_max": 30.0}, "headline_alteration": {"kind": "deep deletion", "altered": 10, "tested": 511, "frequency": 1.96, "is_mutation": false}, "altered_status": "not_observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "not_observed", "frequency_unit": "percent", "cohort_count_status": "not_observed", "cohort_count_unit": "cohorts"}, {"gene": "PDGFRA", "alteration_types": ["SNV / small indel", "amplification"], "altered": 8, "tested": 514, "frequency": 1.56, "cohort_count": 2, "frequency_range": {"min": 1.56, "max": 4.76}, "major_variants": ["S1057F (n=1)", "P519T (n=1)", "E387K (n=1)", "G390S (n=1)", "L580P (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lgg_tcga_pan_can_atlas_2018", "source_record_id": "lgg_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Glioma (MSK, Clin Cancer Res 2019)", "source_url": "https://www.cbioportal.org/study/summary?id=glioma_mskcc_2019", "source_record_id": "glioma_mskcc_2019", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Brain Lower Grade Glioma (TCGA, PanCancer Atlas), 8/514 patients (1.56%).", "Without the 4 hypermutated patients: 6/510 (1.18%).", "Largest alteration is amplification: 19/511 (3.72%) in the reference cohort's copy-number profile.", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "cohort_name": "Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "altered": 8, "tested": 514, "frequency": 1.56, "frequency_excl_hypermutated": 1.18, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "514/514", "coverage_note": null, "source_id": "lgg_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "glioma_mskcc_2019", "cohort_name": "Glioma (MSK, Clin Cancer Res 2019)", "altered": 44, "tested": 924, "frequency": 4.76, "frequency_excl_hypermutated": 4.39, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "1004/1004", "coverage_note": null, "source_id": "glioma_mskcc_2019", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 12.4, "width": 1.0, "reference": 12.4, "scale_max": 30.0}, "headline_alteration": {"kind": "amplification", "altered": 19, "tested": 511, "frequency": 3.72, "is_mutation": false}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "EGFR", "alteration_types": ["SNV / small indel", "amplification"], "altered": 35, "tested": 514, "frequency": 6.81, "cohort_count": 2, "frequency_range": {"min": 6.81, "max": 14.94}, "major_variants": ["G598V (n=6)", "A289V (n=6)", "R252C (n=3)", "L62R (n=3)", "R252P (n=2)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lgg_tcga_pan_can_atlas_2018", "source_record_id": "lgg_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Glioma (MSK, Clin Cancer Res 2019)", "source_url": "https://www.cbioportal.org/study/summary?id=glioma_mskcc_2019", "source_record_id": "glioma_mskcc_2019", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Brain Lower Grade Glioma (TCGA, PanCancer Atlas), 35/514 patients (6.81%).", "Without the 4 hypermutated patients: 34/510 (6.67%).", "Largest alteration is amplification: 39/511 (7.63%) in the reference cohort's copy-number profile.", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "cohort_name": "Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "altered": 35, "tested": 514, "frequency": 6.81, "frequency_excl_hypermutated": 6.67, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "514/514", "coverage_note": null, "source_id": "lgg_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "glioma_mskcc_2019", "cohort_name": "Glioma (MSK, Clin Cancer Res 2019)", "altered": 138, "tested": 924, "frequency": 14.94, "frequency_excl_hypermutated": 14.16, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "1004/1004", "coverage_note": null, "source_id": "glioma_mskcc_2019", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 25.43, "width": 1.0, "reference": 25.43, "scale_max": 30.0}, "headline_alteration": {"kind": "amplification", "altered": 39, "tested": 511, "frequency": 7.63, "is_mutation": false}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "NF1", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 31, "tested": 514, "frequency": 6.03, "cohort_count": 2, "frequency_range": {"min": 6.03, "max": 14.5}, "major_variants": ["F1247Ifs*18 (n=4)", "R2450* (n=2)", "W1314* (n=1)", "Y2285Tfs*5 (n=1)", "L650* (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lgg_tcga_pan_can_atlas_2018", "source_record_id": "lgg_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Glioma (MSK, Clin Cancer Res 2019)", "source_url": "https://www.cbioportal.org/study/summary?id=glioma_mskcc_2019", "source_record_id": "glioma_mskcc_2019", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Brain Lower Grade Glioma (TCGA, PanCancer Atlas), 31/514 patients (6.03%).", "Without the 4 hypermutated patients: 29/510 (5.69%).", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "cohort_name": "Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "altered": 31, "tested": 514, "frequency": 6.03, "frequency_excl_hypermutated": 5.69, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "514/514", "coverage_note": null, "source_id": "lgg_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "glioma_mskcc_2019", "cohort_name": "Glioma (MSK, Clin Cancer Res 2019)", "altered": 134, "tested": 924, "frequency": 14.5, "frequency_excl_hypermutated": 13.5, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "1004/1004", "coverage_note": null, "source_id": "glioma_mskcc_2019", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 20.1, "width": 28.23, "reference": 20.1, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 31, "tested": 514, "frequency": 6.03, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "SMARCA4", "alteration_types": ["SNV / small indel", "amplification"], "altered": 25, "tested": 514, "frequency": 4.86, "cohort_count": 2, "frequency_range": {"min": 4.86, "max": 5.41}, "major_variants": ["K546del (n=4)", "H884R (n=1)", "R1192C (n=1)", "D1177G (n=1)", "L682M (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lgg_tcga_pan_can_atlas_2018", "source_record_id": "lgg_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Glioma (MSK, Clin Cancer Res 2019)", "source_url": "https://www.cbioportal.org/study/summary?id=glioma_mskcc_2019", "source_record_id": "glioma_mskcc_2019", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Brain Lower Grade Glioma (TCGA, PanCancer Atlas), 25/514 patients (4.86%).", "Without the 4 hypermutated patients: 23/510 (4.51%).", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "cohort_name": "Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "altered": 25, "tested": 514, "frequency": 4.86, "frequency_excl_hypermutated": 4.51, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "514/514", "coverage_note": null, "source_id": "lgg_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "glioma_mskcc_2019", "cohort_name": "Glioma (MSK, Clin Cancer Res 2019)", "altered": 50, "tested": 924, "frequency": 5.41, "frequency_excl_hypermutated": 4.28, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "1004/1004", "coverage_note": null, "source_id": "glioma_mskcc_2019", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 16.2, "width": 1.83, "reference": 16.2, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 25, "tested": 514, "frequency": 4.86, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "PTEN", "alteration_types": ["SNV / small indel", "deep deletion"], "altered": 23, "tested": 514, "frequency": 4.47, "cohort_count": 2, "frequency_range": {"min": 4.47, "max": 24.68}, "major_variants": ["T319Nfs*6 (n=2)", "A121T (n=2)", "R173C (n=1)", "S170G (n=1)", "Y346H (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lgg_tcga_pan_can_atlas_2018", "source_record_id": "lgg_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Glioma (MSK, Clin Cancer Res 2019)", "source_url": "https://www.cbioportal.org/study/summary?id=glioma_mskcc_2019", "source_record_id": "glioma_mskcc_2019", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Brain Lower Grade Glioma (TCGA, PanCancer Atlas), 23/514 patients (4.47%).", "Without the 4 hypermutated patients: 22/510 (4.31%).", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "cohort_name": "Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "altered": 23, "tested": 514, "frequency": 4.47, "frequency_excl_hypermutated": 4.31, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "514/514", "coverage_note": null, "source_id": "lgg_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "glioma_mskcc_2019", "cohort_name": "Glioma (MSK, Clin Cancer Res 2019)", "altered": 228, "tested": 924, "frequency": 24.68, "frequency_excl_hypermutated": 24.26, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "1004/1004", "coverage_note": null, "source_id": "glioma_mskcc_2019", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 14.9, "width": 67.37, "reference": 14.9, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 23, "tested": 514, "frequency": 4.47, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "PIK3R1", "alteration_types": ["SNV / small indel", "deep deletion"], "altered": 22, "tested": 514, "frequency": 4.28, "cohort_count": 2, "frequency_range": {"min": 4.28, "max": 8.66}, "major_variants": ["N564D (n=3)", "G376R (n=2)", "D464_Y467del (n=2)", "A185T (n=1)", "A98Gfs*8 (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lgg_tcga_pan_can_atlas_2018", "source_record_id": "lgg_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Glioma (MSK, Clin Cancer Res 2019)", "source_url": "https://www.cbioportal.org/study/summary?id=glioma_mskcc_2019", "source_record_id": "glioma_mskcc_2019", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Brain Lower Grade Glioma (TCGA, PanCancer Atlas), 22/514 patients (4.28%).", "Without the 4 hypermutated patients: 22/510 (4.31%).", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "cohort_name": "Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "altered": 22, "tested": 514, "frequency": 4.28, "frequency_excl_hypermutated": 4.31, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "514/514", "coverage_note": null, "source_id": "lgg_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "glioma_mskcc_2019", "cohort_name": "Glioma (MSK, Clin Cancer Res 2019)", "altered": 80, "tested": 924, "frequency": 8.66, "frequency_excl_hypermutated": 8.23, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "1004/1004", "coverage_note": null, "source_id": "glioma_mskcc_2019", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 14.27, "width": 14.6, "reference": 14.27, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 22, "tested": 514, "frequency": 4.28, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "ZBTB20", "alteration_types": ["SNV / small indel", "deep deletion"], "altered": 20, "tested": 514, "frequency": 3.89, "cohort_count": 1, "frequency_range": {"min": 3.89, "max": 3.89}, "major_variants": ["N650S (n=2)", "M625I (n=1)", "R654C (n=1)", "S245L (n=1)", "Y244C (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lgg_tcga_pan_can_atlas_2018", "source_record_id": "lgg_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Glioma (MSK, Clin Cancer Res 2019)", "source_url": "https://www.cbioportal.org/study/summary?id=glioma_mskcc_2019", "source_record_id": "glioma_mskcc_2019", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Brain Lower Grade Glioma (TCGA, PanCancer Atlas), 20/514 patients (3.89%).", "Without the 4 hypermutated patients: 18/510 (3.53%).", "Observed in 1 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "cohort_name": "Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "altered": 20, "tested": 514, "frequency": 3.89, "frequency_excl_hypermutated": 3.53, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "514/514", "coverage_note": null, "source_id": "lgg_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "glioma_mskcc_2019", "cohort_name": "Glioma (MSK, Clin Cancer Res 2019)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "1004/1004", "coverage_note": null, "source_id": "glioma_mskcc_2019", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 12.97, "width": 1.0, "reference": 12.97, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 20, "tested": 514, "frequency": 3.89, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "ARID1A", "alteration_types": ["SNV / small indel", "deep deletion"], "altered": 19, "tested": 514, "frequency": 3.7, "cohort_count": 2, "frequency_range": {"min": 3.7, "max": 4.65}, "major_variants": ["R1335* (n=1)", "P459L (n=1)", "H203Rfs*196 (n=1)", "A1757S (n=1)", "R1980C (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lgg_tcga_pan_can_atlas_2018", "source_record_id": "lgg_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Glioma (MSK, Clin Cancer Res 2019)", "source_url": "https://www.cbioportal.org/study/summary?id=glioma_mskcc_2019", "source_record_id": "glioma_mskcc_2019", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Brain Lower Grade Glioma (TCGA, PanCancer Atlas), 19/514 patients (3.7%).", "Without the 4 hypermutated patients: 18/510 (3.53%).", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "cohort_name": "Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "altered": 19, "tested": 514, "frequency": 3.7, "frequency_excl_hypermutated": 3.53, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "514/514", "coverage_note": null, "source_id": "lgg_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "glioma_mskcc_2019", "cohort_name": "Glioma (MSK, Clin Cancer Res 2019)", "altered": 43, "tested": 924, "frequency": 4.65, "frequency_excl_hypermutated": 3.95, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "1004/1004", "coverage_note": null, "source_id": "glioma_mskcc_2019", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 12.33, "width": 3.17, "reference": 12.33, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 19, "tested": 514, "frequency": 3.7, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "NIPBL", "alteration_types": ["SNV / small indel", "amplification"], "altered": 18, "tested": 514, "frequency": 3.5, "cohort_count": 1, "frequency_range": {"min": 3.5, "max": 3.5}, "major_variants": ["A1792D (n=1)", "S1443* (n=1)", "P2056A (n=1)", "F2180V (n=1)", "K353N (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lgg_tcga_pan_can_atlas_2018", "source_record_id": "lgg_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Glioma (MSK, Clin Cancer Res 2019)", "source_url": "https://www.cbioportal.org/study/summary?id=glioma_mskcc_2019", "source_record_id": "glioma_mskcc_2019", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Brain Lower Grade Glioma (TCGA, PanCancer Atlas), 18/514 patients (3.5%).", "Without the 4 hypermutated patients: 17/510 (3.33%).", "Observed in 1 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "cohort_name": "Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "altered": 18, "tested": 514, "frequency": 3.5, "frequency_excl_hypermutated": 3.33, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "514/514", "coverage_note": null, "source_id": "lgg_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "glioma_mskcc_2019", "cohort_name": "Glioma (MSK, Clin Cancer Res 2019)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "1004/1004", "coverage_note": null, "source_id": "glioma_mskcc_2019", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 11.67, "width": 1.0, "reference": 11.67, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 18, "tested": 514, "frequency": 3.5, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "BCOR", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 15, "tested": 514, "frequency": 2.92, "cohort_count": 2, "frequency_range": {"min": 2.92, "max": 3.79}, "major_variants": ["R1131Q (n=1)", "E1382Ifs*26 (n=1)", "Q1058Rfs*55 (n=1)", "N1584S (n=1)", "E1386D (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lgg_tcga_pan_can_atlas_2018", "source_record_id": "lgg_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Glioma (MSK, Clin Cancer Res 2019)", "source_url": "https://www.cbioportal.org/study/summary?id=glioma_mskcc_2019", "source_record_id": "glioma_mskcc_2019", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Brain Lower Grade Glioma (TCGA, PanCancer Atlas), 15/514 patients (2.92%).", "Without the 4 hypermutated patients: 14/510 (2.75%).", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "cohort_name": "Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "altered": 15, "tested": 514, "frequency": 2.92, "frequency_excl_hypermutated": 2.75, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "514/514", "coverage_note": null, "source_id": "lgg_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "glioma_mskcc_2019", "cohort_name": "Glioma (MSK, Clin Cancer Res 2019)", "altered": 35, "tested": 924, "frequency": 3.79, "frequency_excl_hypermutated": 3.07, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "1004/1004", "coverage_note": null, "source_id": "glioma_mskcc_2019", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 9.73, "width": 2.9, "reference": 9.73, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 15, "tested": 514, "frequency": 2.92, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "TCF12", "alteration_types": ["SNV / small indel"], "altered": 14, "tested": 514, "frequency": 2.72, "cohort_count": 1, "frequency_range": {"min": 2.72, "max": 2.72}, "major_variants": ["E524Rfs*14 (n=2)", "X229_splice (n=1)", "P292Nfs*44 (n=1)", "D229Afs*9 (n=1)", "X372_splice (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lgg_tcga_pan_can_atlas_2018", "source_record_id": "lgg_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Glioma (MSK, Clin Cancer Res 2019)", "source_url": "https://www.cbioportal.org/study/summary?id=glioma_mskcc_2019", "source_record_id": "glioma_mskcc_2019", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Brain Lower Grade Glioma (TCGA, PanCancer Atlas), 14/514 patients (2.72%).", "Without the 4 hypermutated patients: 14/510 (2.75%).", "Observed in 1 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "cohort_name": "Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "altered": 14, "tested": 514, "frequency": 2.72, "frequency_excl_hypermutated": 2.75, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "514/514", "coverage_note": null, "source_id": "lgg_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "glioma_mskcc_2019", "cohort_name": "Glioma (MSK, Clin Cancer Res 2019)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "1004/1004", "coverage_note": null, "source_id": "glioma_mskcc_2019", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 9.07, "width": 1.0, "reference": 9.07, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 14, "tested": 514, "frequency": 2.72, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "FAT2", "alteration_types": ["SNV / small indel", "amplification"], "altered": 13, "tested": 514, "frequency": 2.53, "cohort_count": 1, "frequency_range": {"min": 2.53, "max": 2.53}, "major_variants": ["P733S (n=1)", "Q678H (n=1)", "V2620A (n=1)", "I1543M (n=1)", "A3754T (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lgg_tcga_pan_can_atlas_2018", "source_record_id": "lgg_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Glioma (MSK, Clin Cancer Res 2019)", "source_url": "https://www.cbioportal.org/study/summary?id=glioma_mskcc_2019", "source_record_id": "glioma_mskcc_2019", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Brain Lower Grade Glioma (TCGA, PanCancer Atlas), 13/514 patients (2.53%).", "Without the 4 hypermutated patients: 12/510 (2.35%).", "Observed in 1 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "cohort_name": "Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "altered": 13, "tested": 514, "frequency": 2.53, "frequency_excl_hypermutated": 2.35, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "514/514", "coverage_note": null, "source_id": "lgg_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "glioma_mskcc_2019", "cohort_name": "Glioma (MSK, Clin Cancer Res 2019)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "1004/1004", "coverage_note": null, "source_id": "glioma_mskcc_2019", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 8.43, "width": 1.0, "reference": 8.43, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 13, "tested": 514, "frequency": 2.53, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "PKHD1", "alteration_types": ["SNV / small indel", "amplification"], "altered": 12, "tested": 514, "frequency": 2.33, "cohort_count": 1, "frequency_range": {"min": 2.33, "max": 2.33}, "major_variants": ["V3043L (n=1)", "V1181F (n=1)", "W2290S (n=1)", "N1602H (n=1)", "P3762Q (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lgg_tcga_pan_can_atlas_2018", "source_record_id": "lgg_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Glioma (MSK, Clin Cancer Res 2019)", "source_url": "https://www.cbioportal.org/study/summary?id=glioma_mskcc_2019", "source_record_id": "glioma_mskcc_2019", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Brain Lower Grade Glioma (TCGA, PanCancer Atlas), 12/514 patients (2.33%).", "Without the 4 hypermutated patients: 12/510 (2.35%).", "Observed in 1 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "cohort_name": "Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "altered": 12, "tested": 514, "frequency": 2.33, "frequency_excl_hypermutated": 2.35, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "514/514", "coverage_note": null, "source_id": "lgg_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "glioma_mskcc_2019", "cohort_name": "Glioma (MSK, Clin Cancer Res 2019)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "1004/1004", "coverage_note": null, "source_id": "glioma_mskcc_2019", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 7.77, "width": 1.0, "reference": 7.77, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 12, "tested": 514, "frequency": 2.33, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "MYH8", "alteration_types": ["SNV / small indel", "amplification"], "altered": 12, "tested": 514, "frequency": 2.33, "cohort_count": 1, "frequency_range": {"min": 2.33, "max": 2.33}, "major_variants": ["A770P (n=1)", "A199V (n=1)", "R1139H (n=1)", "A586S (n=1)", "R1423Q (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lgg_tcga_pan_can_atlas_2018", "source_record_id": "lgg_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Glioma (MSK, Clin Cancer Res 2019)", "source_url": "https://www.cbioportal.org/study/summary?id=glioma_mskcc_2019", "source_record_id": "glioma_mskcc_2019", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Brain Lower Grade Glioma (TCGA, PanCancer Atlas), 12/514 patients (2.33%).", "Without the 4 hypermutated patients: 10/510 (1.96%).", "Observed in 1 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "cohort_name": "Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "altered": 12, "tested": 514, "frequency": 2.33, "frequency_excl_hypermutated": 1.96, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "514/514", "coverage_note": null, "source_id": "lgg_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "glioma_mskcc_2019", "cohort_name": "Glioma (MSK, Clin Cancer Res 2019)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "1004/1004", "coverage_note": null, "source_id": "glioma_mskcc_2019", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 7.77, "width": 1.0, "reference": 7.77, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 12, "tested": 514, "frequency": 2.33, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "MYH2", "alteration_types": ["SNV / small indel", "amplification"], "altered": 12, "tested": 514, "frequency": 2.33, "cohort_count": 1, "frequency_range": {"min": 2.33, "max": 2.33}, "major_variants": ["R1181C (n=2)", "R1199S (n=1)", "R793Q (n=1)", "R1426W (n=1)", "E1139K (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lgg_tcga_pan_can_atlas_2018", "source_record_id": "lgg_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Glioma (MSK, Clin Cancer Res 2019)", "source_url": "https://www.cbioportal.org/study/summary?id=glioma_mskcc_2019", "source_record_id": "glioma_mskcc_2019", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Brain Lower Grade Glioma (TCGA, PanCancer Atlas), 12/514 patients (2.33%).", "Without the 4 hypermutated patients: 11/510 (2.16%).", "Observed in 1 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "cohort_name": "Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "altered": 12, "tested": 514, "frequency": 2.33, "frequency_excl_hypermutated": 2.16, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "514/514", "coverage_note": null, "source_id": "lgg_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "glioma_mskcc_2019", "cohort_name": "Glioma (MSK, Clin Cancer Res 2019)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "1004/1004", "coverage_note": null, "source_id": "glioma_mskcc_2019", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 7.77, "width": 1.0, "reference": 7.77, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 12, "tested": 514, "frequency": 2.33, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "HSPG2", "alteration_types": ["SNV / small indel"], "altered": 12, "tested": 514, "frequency": 2.33, "cohort_count": 1, "frequency_range": {"min": 2.33, "max": 2.33}, "major_variants": ["V3202M (n=1)", "R1200W (n=1)", "R2992H (n=1)", "G2065W (n=1)", "P1596H (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lgg_tcga_pan_can_atlas_2018", "source_record_id": "lgg_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Glioma (MSK, Clin Cancer Res 2019)", "source_url": "https://www.cbioportal.org/study/summary?id=glioma_mskcc_2019", "source_record_id": "glioma_mskcc_2019", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Brain Lower Grade Glioma (TCGA, PanCancer Atlas), 12/514 patients (2.33%).", "Without the 4 hypermutated patients: 9/510 (1.76%).", "Observed in 1 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "cohort_name": "Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "altered": 12, "tested": 514, "frequency": 2.33, "frequency_excl_hypermutated": 1.76, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "514/514", "coverage_note": null, "source_id": "lgg_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "glioma_mskcc_2019", "cohort_name": "Glioma (MSK, Clin Cancer Res 2019)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "1004/1004", "coverage_note": null, "source_id": "glioma_mskcc_2019", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 7.77, "width": 1.0, "reference": 7.77, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 12, "tested": 514, "frequency": 2.33, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "FRAS1", "alteration_types": ["SNV / small indel", "deep deletion"], "altered": 12, "tested": 514, "frequency": 2.33, "cohort_count": 1, "frequency_range": {"min": 2.33, "max": 2.33}, "major_variants": ["F2731C (n=1)", "A3904V (n=1)", "N3064S (n=1)", "V3453I (n=1)", "C379* (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lgg_tcga_pan_can_atlas_2018", "source_record_id": "lgg_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Glioma (MSK, Clin Cancer Res 2019)", "source_url": "https://www.cbioportal.org/study/summary?id=glioma_mskcc_2019", "source_record_id": "glioma_mskcc_2019", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Brain Lower Grade Glioma (TCGA, PanCancer Atlas), 12/514 patients (2.33%).", "Without the 4 hypermutated patients: 12/510 (2.35%).", "Observed in 1 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "cohort_name": "Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "altered": 12, "tested": 514, "frequency": 2.33, "frequency_excl_hypermutated": 2.35, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "514/514", "coverage_note": null, "source_id": "lgg_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "glioma_mskcc_2019", "cohort_name": "Glioma (MSK, Clin Cancer Res 2019)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "1004/1004", "coverage_note": null, "source_id": "glioma_mskcc_2019", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 7.77, "width": 1.0, "reference": 7.77, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 12, "tested": 514, "frequency": 2.33, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "DNMT3A", "alteration_types": ["SNV / small indel", "deep deletion"], "altered": 12, "tested": 514, "frequency": 2.33, "cohort_count": 2, "frequency_range": {"min": 2.33, "max": 2.81}, "major_variants": ["R183W (n=1)", "E667* (n=1)", "C540Y (n=1)", "F732L (n=1)", "A259G (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lgg_tcga_pan_can_atlas_2018", "source_record_id": "lgg_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Glioma (MSK, Clin Cancer Res 2019)", "source_url": "https://www.cbioportal.org/study/summary?id=glioma_mskcc_2019", "source_record_id": "glioma_mskcc_2019", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Brain Lower Grade Glioma (TCGA, PanCancer Atlas), 12/514 patients (2.33%).", "Without the 4 hypermutated patients: 9/510 (1.76%).", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "cohort_name": "Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "altered": 12, "tested": 514, "frequency": 2.33, "frequency_excl_hypermutated": 1.76, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "514/514", "coverage_note": null, "source_id": "lgg_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "glioma_mskcc_2019", "cohort_name": "Glioma (MSK, Clin Cancer Res 2019)", "altered": 26, "tested": 924, "frequency": 2.81, "frequency_excl_hypermutated": 2.09, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "1004/1004", "coverage_note": null, "source_id": "glioma_mskcc_2019", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 7.77, "width": 1.6, "reference": 7.77, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 12, "tested": 514, "frequency": 2.33, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "COL6A3", "alteration_types": ["SNV / small indel", "deep deletion"], "altered": 12, "tested": 514, "frequency": 2.33, "cohort_count": 1, "frequency_range": {"min": 2.33, "max": 2.33}, "major_variants": ["R1331H (n=2)", "A2611V (n=1)", "R1798H (n=1)", "R494K (n=1)", "A2536V (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lgg_tcga_pan_can_atlas_2018", "source_record_id": "lgg_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Glioma (MSK, Clin Cancer Res 2019)", "source_url": "https://www.cbioportal.org/study/summary?id=glioma_mskcc_2019", "source_record_id": "glioma_mskcc_2019", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Brain Lower Grade Glioma (TCGA, PanCancer Atlas), 12/514 patients (2.33%).", "Without the 4 hypermutated patients: 10/510 (1.96%).", "Largest alteration is deep deletion: 18/511 (3.52%) in the reference cohort's copy-number profile.", "Observed in 1 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "cohort_name": "Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "altered": 12, "tested": 514, "frequency": 2.33, "frequency_excl_hypermutated": 1.96, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "514/514", "coverage_note": null, "source_id": "lgg_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "glioma_mskcc_2019", "cohort_name": "Glioma (MSK, Clin Cancer Res 2019)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "1004/1004", "coverage_note": null, "source_id": "glioma_mskcc_2019", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 11.73, "width": 1.0, "reference": 11.73, "scale_max": 30.0}, "headline_alteration": {"kind": "deep deletion", "altered": 18, "tested": 511, "frequency": 3.52, "is_mutation": false}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "NPAP1", "alteration_types": ["SNV / small indel", "deep deletion"], "altered": 11, "tested": 514, "frequency": 2.14, "cohort_count": 1, "frequency_range": {"min": 2.14, "max": 2.14}, "major_variants": ["G183R (n=1)", "E155D (n=1)", "S331L (n=1)", "T512A (n=1)", "P237S (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lgg_tcga_pan_can_atlas_2018", "source_record_id": "lgg_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Glioma (MSK, Clin Cancer Res 2019)", "source_url": "https://www.cbioportal.org/study/summary?id=glioma_mskcc_2019", "source_record_id": "glioma_mskcc_2019", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Brain Lower Grade Glioma (TCGA, PanCancer Atlas), 11/514 patients (2.14%).", "Without the 4 hypermutated patients: 9/510 (1.76%).", "Observed in 1 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "cohort_name": "Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "altered": 11, "tested": 514, "frequency": 2.14, "frequency_excl_hypermutated": 1.76, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "514/514", "coverage_note": null, "source_id": "lgg_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "glioma_mskcc_2019", "cohort_name": "Glioma (MSK, Clin Cancer Res 2019)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "1004/1004", "coverage_note": null, "source_id": "glioma_mskcc_2019", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 7.13, "width": 1.0, "reference": 7.13, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 11, "tested": 514, "frequency": 2.14, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "KMT2D", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 11, "tested": 514, "frequency": 2.14, "cohort_count": 2, "frequency_range": {"min": 2.14, "max": 4.76}, "major_variants": ["A16T (n=1)", "R1312C (n=1)", "E559D (n=1)", "G1059E (n=1)", "M581V (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lgg_tcga_pan_can_atlas_2018", "source_record_id": "lgg_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Glioma (MSK, Clin Cancer Res 2019)", "source_url": "https://www.cbioportal.org/study/summary?id=glioma_mskcc_2019", "source_record_id": "glioma_mskcc_2019", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Brain Lower Grade Glioma (TCGA, PanCancer Atlas), 11/514 patients (2.14%).", "Without the 4 hypermutated patients: 8/510 (1.57%).", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "cohort_name": "Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "altered": 11, "tested": 514, "frequency": 2.14, "frequency_excl_hypermutated": 1.57, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "514/514", "coverage_note": null, "source_id": "lgg_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": 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"cohort_count": 1, "frequency_range": {"min": 2.14, "max": 2.14}, "major_variants": ["T1203Rfs*21 (n=4)", "T1279Hfs*9 (n=1)", "P1607H (n=1)", "A2034T (n=1)", "I763M (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lgg_tcga_pan_can_atlas_2018", "source_record_id": "lgg_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Glioma (MSK, Clin Cancer Res 2019)", "source_url": "https://www.cbioportal.org/study/summary?id=glioma_mskcc_2019", "source_record_id": "glioma_mskcc_2019", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Brain Lower Grade Glioma (TCGA, PanCancer Atlas), 11/514 patients (2.14%).", "Without the 4 hypermutated patients: 10/510 (1.96%).", "Observed in 1 of 2 cohorts; frequencies are 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"retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Brain Lower Grade Glioma (TCGA, PanCancer Atlas), 11/514 patients (2.14%).", "Without the 4 hypermutated patients: 10/510 (1.96%).", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "cohort_name": "Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "altered": 11, "tested": 514, "frequency": 2.14, "frequency_excl_hypermutated": 1.96, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "514/514", "coverage_note": null, "source_id": "lgg_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "glioma_mskcc_2019", "cohort_name": "Glioma (MSK, Clin Cancer Res 2019)", "altered": 40, "tested": 924, "frequency": 4.33, "frequency_excl_hypermutated": 3.29, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "1004/1004", "coverage_note": null, "source_id": "glioma_mskcc_2019", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 7.13, "width": 7.3, "reference": 7.13, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 11, "tested": 514, "frequency": 2.14, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "ANKRD30A", "alteration_types": ["SNV / small indel", "amplification"], "altered": 11, 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"processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Glioma (MSK, Clin Cancer Res 2019)", "source_url": "https://www.cbioportal.org/study/summary?id=glioma_mskcc_2019", "source_record_id": "glioma_mskcc_2019", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Brain Lower Grade Glioma (TCGA, PanCancer Atlas), 11/514 patients (2.14%).", "Without the 4 hypermutated patients: 11/510 (2.16%).", "Observed in 1 of 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[], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lgg_tcga_pan_can_atlas_2018", "source_record_id": "lgg_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Glioma (MSK, Clin Cancer Res 2019)", "source_url": "https://www.cbioportal.org/study/summary?id=glioma_mskcc_2019", "source_record_id": "glioma_mskcc_2019", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Brain Lower Grade Glioma (TCGA, PanCancer Atlas), 10/514 patients (1.95%).", "Without the 4 hypermutated patients: 7/510 (1.37%).", "Observed in 1 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "cohort_name": "Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "altered": 10, "tested": 514, "frequency": 1.95, "frequency_excl_hypermutated": 1.37, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "514/514", "coverage_note": null, "source_id": "lgg_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "glioma_mskcc_2019", "cohort_name": "Glioma (MSK, Clin Cancer Res 2019)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "1004/1004", "coverage_note": null, "source_id": "glioma_mskcc_2019", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 6.5, "width": 1.0, "reference": 6.5, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 10, "tested": 514, "frequency": 1.95, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "SPATA31E1", "alteration_types": ["SNV / 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"source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Glioma (MSK, Clin Cancer Res 2019)", "source_url": "https://www.cbioportal.org/study/summary?id=glioma_mskcc_2019", "source_record_id": "glioma_mskcc_2019", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Brain Lower Grade Glioma (TCGA, PanCancer Atlas), 10/514 patients (1.95%).", "Without the 4 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"ensembl_id": null, "chromosome": null, "range_plot": {"left": 6.5, "width": 1.0, "reference": 6.5, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 10, "tested": 514, "frequency": 1.95, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "SETD2", "alteration_types": ["SNV / small indel", "deep deletion"], "altered": 10, "tested": 514, "frequency": 1.95, "cohort_count": 2, "frequency_range": {"min": 1.95, "max": 5.41}, "major_variants": ["L2081Kfs*4 (n=1)", "Q2347Hfs*23 (n=1)", "H1603R (n=1)", "S917Kfs*18 (n=1)", "S784Y (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from 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"https://www.cbioportal.org/study/summary?id=glioma_mskcc_2019", "source_record_id": "glioma_mskcc_2019", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Brain Lower Grade Glioma (TCGA, PanCancer Atlas), 10/514 patients (1.95%).", "Without the 4 hypermutated patients: 9/510 (1.76%).", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "cohort_name": "Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "altered": 10, "tested": 514, "frequency": 1.95, "frequency_excl_hypermutated": 1.76, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": 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"cohort_count_unit": "cohorts"}, {"gene": "ROS1", "alteration_types": ["SNV / small indel", "deep deletion"], "altered": 10, "tested": 514, "frequency": 1.95, "cohort_count": 2, "frequency_range": {"min": 1.95, "max": 2.6}, "major_variants": ["G1137E (n=1)", "T16Lfs*15 (n=1)", "X866_splice (n=1)", "I1900V (n=1)", "R1035* (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lgg_tcga_pan_can_atlas_2018", "source_record_id": "lgg_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Glioma (MSK, Clin Cancer Res 2019)", "source_url": "https://www.cbioportal.org/study/summary?id=glioma_mskcc_2019", "source_record_id": "glioma_mskcc_2019", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], 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"coverage_note": null, "source_id": "glioma_mskcc_2019", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 6.5, "width": 2.17, "reference": 6.5, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 10, "tested": 514, "frequency": 1.95, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "MYO15A", "alteration_types": ["SNV / small indel"], "altered": 10, "tested": 514, "frequency": 1.95, "cohort_count": 1, "frequency_range": {"min": 1.95, "max": 1.95}, "major_variants": ["G2423S (n=2)", "A2874T (n=1)", "E494D (n=1)", "D247N (n=1)", "S449Y (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", 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"frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "MYH1", "alteration_types": ["SNV / small indel", "amplification"], "altered": 10, "tested": 514, "frequency": 1.95, "cohort_count": 1, "frequency_range": {"min": 1.95, "max": 1.95}, "major_variants": ["E99K (n=1)", "I1580S (n=1)", "R191H (n=1)", "F1089L (n=1)", "A1255T (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lgg_tcga_pan_can_atlas_2018", "source_record_id": "lgg_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Glioma (MSK, Clin Cancer Res 2019)", "source_url": "https://www.cbioportal.org/study/summary?id=glioma_mskcc_2019", "source_record_id": "glioma_mskcc_2019", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], 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false, "coverage": "1004/1004", "coverage_note": null, "source_id": "glioma_mskcc_2019", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 6.5, "width": 1.0, "reference": 6.5, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 10, "tested": 514, "frequency": 1.95, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "ITIH6", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 10, "tested": 514, "frequency": 1.95, "cohort_count": 1, "frequency_range": {"min": 1.95, "max": 1.95}, "major_variants": ["S1165P (n=1)", "D289G (n=1)", "T1156A (n=1)", "V1270M (n=1)", "G403S (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most 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{"source_name": "cBioPortal · Glioma (MSK, Clin Cancer Res 2019)", "source_url": "https://www.cbioportal.org/study/summary?id=glioma_mskcc_2019", "source_record_id": "glioma_mskcc_2019", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Brain Lower Grade Glioma (TCGA, PanCancer Atlas), 10/514 patients (1.95%).", "Without the 4 hypermutated patients: 9/510 (1.76%).", "Largest alteration is amplification: 14/511 (2.74%) in the reference cohort's copy-number profile.", "Observed in 1 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "cohort_name": "Brain Lower Grade Glioma (TCGA, 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false}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "FLNC", "alteration_types": ["SNV / small indel", "amplification"], "altered": 10, "tested": 514, "frequency": 1.95, "cohort_count": 1, "frequency_range": {"min": 1.95, "max": 1.95}, "major_variants": ["V2658M (n=1)", "A29V (n=1)", "A1551T (n=1)", "G2420V (n=1)", "Q2212K (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is 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"cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Brain Lower Grade Glioma (TCGA, PanCancer Atlas), 10/514 patients (1.95%).", "Without the 4 hypermutated patients: 7/510 (1.37%).", "Observed in 1 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "cohort_name": "Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "altered": 10, "tested": 514, "frequency": 1.95, "frequency_excl_hypermutated": 1.37, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "514/514", "coverage_note": null, "source_id": "lgg_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "glioma_mskcc_2019", "cohort_name": "Glioma (MSK, Clin Cancer Res 2019)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "1004/1004", "coverage_note": null, "source_id": "glioma_mskcc_2019", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 6.5, "width": 1.0, "reference": 6.5, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 10, "tested": 514, "frequency": 1.95, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "EPPK1", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 10, "tested": 514, "frequency": 1.95, "cohort_count": 1, "frequency_range": {"min": 1.95, "max": 1.95}, "major_variants": ["R686C (n=1)", "R2032K (n=1)", "S1332A (n=1)", "E1962K (n=1)", "P36T (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lgg_tcga_pan_can_atlas_2018", "source_record_id": "lgg_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Glioma (MSK, Clin Cancer Res 2019)", "source_url": "https://www.cbioportal.org/study/summary?id=glioma_mskcc_2019", "source_record_id": "glioma_mskcc_2019", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Brain Lower Grade Glioma (TCGA, PanCancer Atlas), 10/514 patients (1.95%).", "Without the 4 hypermutated patients: 9/510 (1.76%).", "Largest alteration is amplification: 18/511 (3.52%) in the reference cohort's copy-number profile.", "Observed in 1 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "cohort_name": "Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "altered": 10, "tested": 514, "frequency": 1.95, "frequency_excl_hypermutated": 1.76, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "514/514", "coverage_note": null, "source_id": "lgg_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "glioma_mskcc_2019", "cohort_name": "Glioma (MSK, Clin Cancer Res 2019)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "1004/1004", "coverage_note": null, "source_id": "glioma_mskcc_2019", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 11.73, "width": 1.0, "reference": 11.73, 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"tested_unit": "patients", "frequency": 10.76, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["lgg_tcga_pan_can_atlas_2018"], "source_ids": ["lgg_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "EGFR", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "EGFR amplification", "genomic_coordinate": null, "observed": 39, "observed_status": "observed", "observed_unit": "patients", "tested": 511, "tested_status": "observed", "tested_unit": "patients", "frequency": 7.63, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["lgg_tcga_pan_can_atlas_2018"], "source_ids": ["lgg_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "PDGFRA", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "PDGFRA amplification", "genomic_coordinate": null, "observed": 65, "observed_status": "observed", "observed_unit": "patients", "tested": 924, "tested_status": "observed", "tested_unit": "patients", "frequency": 7.03, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["glioma_mskcc_2019"], "source_ids": ["glioma_mskcc_2019_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "PTEN", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "deep deletion", "event_label": "PTEN deep deletion", "genomic_coordinate": null, "observed": 61, "observed_status": "observed", "observed_unit": "patients", "tested": 924, "tested_status": "observed", "tested_unit": "patients", "frequency": 6.6, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["glioma_mskcc_2019"], "source_ids": ["glioma_mskcc_2019_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "PDGFRA", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "PDGFRA amplification", "genomic_coordinate": null, "observed": 19, "observed_status": "observed", "observed_unit": "patients", "tested": 511, "tested_status": "observed", "tested_unit": "patients", "frequency": 3.72, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["lgg_tcga_pan_can_atlas_2018"], "source_ids": ["lgg_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "COL6A3", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "deep deletion", "event_label": "COL6A3 deep deletion", "genomic_coordinate": null, "observed": 18, "observed_status": "observed", "observed_unit": "patients", "tested": 511, "tested_status": "observed", "tested_unit": "patients", "frequency": 3.52, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["lgg_tcga_pan_can_atlas_2018"], "source_ids": ["lgg_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "EPPK1", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "EPPK1 amplification", "genomic_coordinate": null, "observed": 18, "observed_status": "observed", "observed_unit": "patients", "tested": 511, "tested_status": "observed", "tested_unit": "patients", "frequency": 3.52, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["lgg_tcga_pan_can_atlas_2018"], "source_ids": ["lgg_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "ITIH6", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "ITIH6 amplification", "genomic_coordinate": null, "observed": 14, "observed_status": "observed", "observed_unit": "patients", "tested": 511, "tested_status": "observed", "tested_unit": "patients", "frequency": 2.74, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["lgg_tcga_pan_can_atlas_2018"], "source_ids": ["lgg_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "ATRX", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "deep deletion", "event_label": "ATRX deep deletion", "genomic_coordinate": null, "observed": 11, "observed_status": "observed", "observed_unit": "patients", "tested": 511, "tested_status": "observed", "tested_unit": "patients", "frequency": 2.15, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["lgg_tcga_pan_can_atlas_2018"], "source_ids": ["lgg_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}], "modality_summary": [{"modality": "SNV / small indel", "available_cohorts": 2, "total_cohorts": 2}, {"modality": "Copy number (discrete)", "available_cohorts": 2, "total_cohorts": 2}, {"modality": "Structural variant (present, not read)", "available_cohorts": 2, "total_cohorts": 2}], "chromosome_summary": [], "cohorts": [{"name": "Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "source": "cBioPortal", "accession": "lgg_tcga_pan_can_atlas_2018", "patients": {"value": 514, "status": "observed", "unit": "patients"}, "samples": {"value": 514, "status": "observed", "unit": "samples"}, "disease_subtype": "Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "assay_type": "exome or genome", "sequencing_method": "WES (514)", "genome_build": "hg19", "alteration_types_available": ["SNV", "small indel", "amplification", "deep deletion", "structural variant (profile present, not read)"], "genes_assayed": "all coding genes", "primary_or_metastatic": null, "age_group": null, "retrieved_at": "2026-09-18", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "source_record_id": "lgg_tcga_pan_can_atlas_2018", "is_demo": false, "assay_coverage": {"patients_with_calls": 514, "patients_in_roster": 514, "frequencies_computed": true, "samples_sequenced": 514, "samples_in_study": 514, "hypermutated_patients": 4, "median_mutations_per_sample": 27.0, "reason": null}}, {"name": "Glioma (MSK, Clin Cancer Res 2019)", "source": "cBioPortal", "accession": "glioma_mskcc_2019", "patients": {"value": 924, "status": "observed", "unit": "patients"}, "samples": {"value": 1004, "status": "observed", "unit": "samples"}, "disease_subtype": "Glioma (MSK, Clin Cancer Res 2019)", "assay_type": "targeted panel", "sequencing_method": "IMPACT410 (505), IMPACT468 (207), IMPACT341 (125), glioma_mskcc_2019_fmi_t5 (122), glioma_mskcc_2019_fmi_t7 (45)", "genome_build": "hg19", "alteration_types_available": ["SNV", "small indel", "amplification", "deep deletion", "structural variant (profile present, not read)"], "genes_assayed": "panel genes only; per-gene denominators", "primary_or_metastatic": null, "age_group": null, "retrieved_at": "2026-09-18", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "source_record_id": "glioma_mskcc_2019", "is_demo": false, "assay_coverage": {"patients_with_calls": 924, "patients_in_roster": 924, "frequencies_computed": true, "samples_sequenced": 1004, "samples_in_study": 1004, "hypermutated_patients": 13, "median_mutations_per_sample": 4.0, "reason": null}}], "sources": [{"source_name": "cBioPortal · Brain Lower Grade Glioma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=lgg_tcga_pan_can_atlas_2018", "source_record_id": "lgg_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Glioma (MSK, Clin Cancer Res 2019)", "source_url": "https://www.cbioportal.org/study/summary?id=glioma_mskcc_2019", "source_record_id": "glioma_mskcc_2019", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "limitations": ["A cBioPortal public-API snapshot retrieved 2026-09-18; the page does not refresh source data at request time.", "Counts are patients with at least one non-silent call in the study's sequenced sample list; silent, intronic and UTR calls are excluded.", "For targeted-panel cohorts each gene divides by the patients whose panel carried it; a gene absent from the panel is shown as not assayed, not as zero.", "Copy-number rows use discrete calls (2 = high-level amplification, −2 = deep deletion) against the cohort's copy-number sample list, which is a different roster from the sequenced one.", "Cohorts are not pooled. Cross-study patient overlap has not been checked and no disease-wide frequency is reported.", "Structural variants and fusions are not read in this snapshot even where the study carries a profile; germline variants, mutational signatures, TMB and MSI are not reported.", "The gene set is the briefing's curated targets plus the reference cohort's most frequently mutated genes; it is not genome-wide."], "answer_block": ["In Brain Lower Grade Glioma (TCGA, PanCancer Atlas) (514 sequenced patients, exome or genome), the most frequently altered of the 44 genes shown are IDH1 76.85%, TP53 48.25%, ATRX 37.55%, CIC 21.01%, CDKN2A 10.76% (deep deletion). Each figure divides by the patients on whom that gene could be called.", "4 of 514 patients are hypermutated (more than 270 non-silent mutations, ten times the cohort median of 27); every gene's frequency without them is beside the headline.", "Of the briefing's 12 curated targets, 2 are altered in under 2% of this cohort (TERT, MGMT): targets by expression, dependency or drug label, not by mutation. Frequency is not targetability, in either direction.", "2 cohorts are shown and none are pooled; overlap between them has not been checked and there is no disease-wide percentage."], "key_findings": [{"finding": "IDH1 is mutated in 395 of 514 patients in Brain Lower Grade Glioma (TCGA, PanCancer Atlas).", "numerator": 395, "denominator": 514, "frequency": 76.85, "cohorts": 2, "evidence_confidence": "moderate", "source": "lgg_tcga_pan_can_atlas_2018", "retrieved_at": "2026-09-18"}, {"finding": "TP53 is mutated in 248 of 514 patients in Brain Lower Grade Glioma (TCGA, PanCancer Atlas).", "numerator": 248, "denominator": 514, "frequency": 48.25, "cohorts": 2, "evidence_confidence": "moderate", "source": "lgg_tcga_pan_can_atlas_2018", "retrieved_at": "2026-09-18"}, {"finding": "ATRX is mutated in 193 of 514 patients in Brain Lower Grade Glioma (TCGA, PanCancer Atlas).", "numerator": 193, "denominator": 514, "frequency": 37.55, "cohorts": 2, "evidence_confidence": "moderate", "source": "lgg_tcga_pan_can_atlas_2018", "retrieved_at": "2026-09-18"}], "research_gaps": [{"kind": "Structural variants", "text": "Read the structural-variant profiles the studies carry; fusions are the defining event in several of these diseases."}, {"kind": "Context", "text": "Stage, subtype, age and treatment line are not attached to any count; the cohorts differ on all four."}, {"kind": "Interpretation", "text": "Activating versus inactivating, actionable versus not, and evidence level are not inferred here; the briefing's target table carries the drug and trial facts."}], "observations": [], "data_status": "PUBLIC SOURCE SNAPSHOT", "is_demo": false, "reference_cohort": "lgg_tcga_pan_can_atlas_2018", "region_events": [], "matrix": [{"label": "IDH1", "kind": "SNV / small indel", "gene": "IDH1", "cells": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 76.85, "altered": 395, "tested": 514, "note": null}, {"cohort": "glioma_mskcc_2019", "status": "observed", "frequency": 34.09, "altered": 315, "tested": 924, "note": null}]}, {"label": "IDH2", "kind": "SNV / small indel", "gene": "IDH2", "cells": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 4.09, "altered": 21, "tested": 514, "note": null}, {"cohort": "glioma_mskcc_2019", "status": "observed", "frequency": 2.49, "altered": 23, "tested": 924, "note": null}]}, {"label": "TP53", "kind": "SNV / small indel", "gene": "TP53", "cells": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 48.25, "altered": 248, "tested": 514, "note": null}, {"cohort": "glioma_mskcc_2019", "status": "observed", "frequency": 40.58, "altered": 375, "tested": 924, "note": null}]}, {"label": "ATRX", "kind": "SNV / small indel", "gene": "ATRX", "cells": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 37.55, "altered": 193, "tested": 514, "note": null}, {"cohort": "glioma_mskcc_2019", "status": "observed", "frequency": 22.08, "altered": 204, "tested": 924, "note": null}]}, {"label": "ATRX", "kind": "deep deletion", "gene": "ATRX", "cells": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 2.15, "altered": 11, "tested": 511, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "glioma_mskcc_2019", "status": "observed", "frequency": 0.65, "altered": 6, "tested": 924, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "CIC", "kind": "SNV / small indel", "gene": "CIC", "cells": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 21.01, "altered": 108, "tested": 514, "note": null}, {"cohort": "glioma_mskcc_2019", "status": "observed", "frequency": 13.1, "altered": 121, "tested": 924, "note": null}]}, {"label": "FUBP1", "kind": "SNV / small indel", "gene": "FUBP1", "cells": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 8.95, "altered": 46, "tested": 514, "note": null}, {"cohort": "glioma_mskcc_2019", "status": "observed", "frequency": 5.02, "altered": 41, "tested": 816, "note": null}]}, {"label": "CDKN2A", "kind": "SNV / small indel", "gene": "CDKN2A", "cells": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 0.58, "altered": 3, "tested": 514, "note": null}, {"cohort": "glioma_mskcc_2019", "status": "observed", "frequency": 1.95, "altered": 18, "tested": 924, "note": null}]}, {"label": "CDKN2A", "kind": "deep deletion", "gene": "CDKN2A", "cells": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 10.76, "altered": 55, "tested": 511, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "glioma_mskcc_2019", "status": "observed", "frequency": 30.63, "altered": 283, "tested": 924, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "TERT", "kind": "SNV / small indel", "gene": "TERT", "cells": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 0.39, "altered": 2, "tested": 514, "note": null}, {"cohort": "glioma_mskcc_2019", "status": "observed", "frequency": 2.45, "altered": 20, "tested": 816, "note": null}]}, {"label": "PIK3CA", "kind": "SNV / small indel", "gene": "PIK3CA", "cells": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 8.17, "altered": 42, "tested": 514, "note": null}, {"cohort": "glioma_mskcc_2019", "status": "observed", "frequency": 11.69, "altered": 108, "tested": 924, "note": null}]}, {"label": "NOTCH1", "kind": "SNV / small indel", "gene": "NOTCH1", "cells": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 7.39, "altered": 38, "tested": 514, "note": null}, {"cohort": "glioma_mskcc_2019", "status": "observed", "frequency": 7.25, "altered": 67, "tested": 924, "note": null}]}, {"label": "MGMT", "kind": "SNV / small indel", "gene": "MGMT", "cells": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 514, "note": null}, {"cohort": "glioma_mskcc_2019", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "PDGFRA", "kind": "SNV / small indel", "gene": "PDGFRA", "cells": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 1.56, "altered": 8, "tested": 514, "note": null}, {"cohort": "glioma_mskcc_2019", "status": "observed", "frequency": 4.76, "altered": 44, "tested": 924, "note": null}]}, {"label": "PDGFRA", "kind": "amplification", "gene": "PDGFRA", "cells": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.72, "altered": 19, "tested": 511, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "glioma_mskcc_2019", "status": "observed", "frequency": 7.03, "altered": 65, "tested": 924, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "EGFR", "kind": "SNV / small indel", "gene": "EGFR", "cells": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 6.81, "altered": 35, "tested": 514, "note": null}, {"cohort": "glioma_mskcc_2019", "status": "observed", "frequency": 14.94, "altered": 138, "tested": 924, "note": null}]}, {"label": "EGFR", "kind": "amplification", "gene": "EGFR", "cells": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 7.63, "altered": 39, "tested": 511, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "glioma_mskcc_2019", "status": "observed", "frequency": 22.84, "altered": 211, "tested": 924, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "NF1", "kind": "SNV / small indel", "gene": "NF1", "cells": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 6.03, "altered": 31, "tested": 514, "note": null}, {"cohort": "glioma_mskcc_2019", "status": "observed", "frequency": 14.5, "altered": 134, "tested": 924, "note": null}]}, {"label": "SMARCA4", "kind": "SNV / small indel", "gene": "SMARCA4", "cells": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 4.86, "altered": 25, "tested": 514, "note": null}, {"cohort": "glioma_mskcc_2019", "status": "observed", "frequency": 5.41, "altered": 50, "tested": 924, "note": null}]}, {"label": "PTEN", "kind": "SNV / small indel", "gene": "PTEN", "cells": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 4.47, "altered": 23, "tested": 514, "note": null}, {"cohort": "glioma_mskcc_2019", "status": "observed", "frequency": 24.68, "altered": 228, "tested": 924, "note": null}]}, {"label": "PTEN", "kind": "deep deletion", "gene": "PTEN", "cells": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 0.98, "altered": 5, "tested": 511, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "glioma_mskcc_2019", "status": "observed", "frequency": 6.6, "altered": 61, "tested": 924, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "PIK3R1", "kind": "SNV / small indel", "gene": "PIK3R1", "cells": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 4.28, "altered": 22, "tested": 514, "note": null}, {"cohort": "glioma_mskcc_2019", "status": "observed", "frequency": 8.66, "altered": 80, "tested": 924, "note": null}]}, {"label": "ZBTB20", "kind": "SNV / small indel", "gene": "ZBTB20", "cells": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.89, "altered": 20, "tested": 514, "note": null}, {"cohort": "glioma_mskcc_2019", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "ARID1A", "kind": "SNV / small indel", "gene": "ARID1A", "cells": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.7, "altered": 19, "tested": 514, "note": null}, {"cohort": "glioma_mskcc_2019", "status": "observed", "frequency": 4.65, "altered": 43, "tested": 924, "note": null}]}, {"label": "NIPBL", "kind": "SNV / small indel", "gene": "NIPBL", "cells": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.5, "altered": 18, "tested": 514, "note": null}, {"cohort": "glioma_mskcc_2019", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "BCOR", "kind": "SNV / small indel", "gene": "BCOR", "cells": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 2.92, "altered": 15, "tested": 514, "note": null}, {"cohort": "glioma_mskcc_2019", "status": "observed", "frequency": 3.79, "altered": 35, "tested": 924, "note": null}]}, {"label": "TCF12", "kind": "SNV / small indel", "gene": "TCF12", "cells": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 2.72, "altered": 14, "tested": 514, "note": null}, {"cohort": "glioma_mskcc_2019", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "FAT2", "kind": "SNV / small indel", "gene": "FAT2", "cells": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 2.53, "altered": 13, "tested": 514, "note": null}, {"cohort": "glioma_mskcc_2019", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "PKHD1", "kind": "SNV / small indel", "gene": "PKHD1", "cells": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 2.33, "altered": 12, "tested": 514, "note": null}, {"cohort": "glioma_mskcc_2019", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "MYH8", "kind": "SNV / small indel", "gene": "MYH8", "cells": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 2.33, "altered": 12, "tested": 514, "note": null}, {"cohort": "glioma_mskcc_2019", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "MYH2", "kind": "SNV / small indel", "gene": "MYH2", "cells": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 2.33, "altered": 12, "tested": 514, "note": null}, {"cohort": "glioma_mskcc_2019", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "HSPG2", "kind": "SNV / small indel", "gene": "HSPG2", "cells": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 2.33, "altered": 12, "tested": 514, "note": null}, {"cohort": "glioma_mskcc_2019", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "FRAS1", "kind": "SNV / small indel", "gene": "FRAS1", "cells": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 2.33, "altered": 12, "tested": 514, "note": null}, {"cohort": "glioma_mskcc_2019", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "DNMT3A", "kind": "SNV / small indel", "gene": "DNMT3A", "cells": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 2.33, "altered": 12, "tested": 514, "note": null}, {"cohort": "glioma_mskcc_2019", "status": "observed", "frequency": 2.81, "altered": 26, "tested": 924, "note": null}]}, {"label": "COL6A3", "kind": "SNV / small indel", "gene": "COL6A3", "cells": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 2.33, "altered": 12, "tested": 514, "note": null}, {"cohort": "glioma_mskcc_2019", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "COL6A3", "kind": "deep deletion", "gene": "COL6A3", "cells": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.52, "altered": 18, "tested": 511, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "glioma_mskcc_2019", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 924, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "NPAP1", "kind": "SNV / small indel", "gene": "NPAP1", "cells": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 2.14, "altered": 11, "tested": 514, "note": null}, {"cohort": "glioma_mskcc_2019", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "KMT2D", "kind": "SNV / small indel", "gene": "KMT2D", "cells": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 2.14, "altered": 11, "tested": 514, "note": null}, {"cohort": "glioma_mskcc_2019", "status": "observed", "frequency": 4.76, "altered": 44, "tested": 924, "note": null}]}, {"label": "KAT6B", "kind": "SNV / small indel", "gene": "KAT6B", "cells": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 2.14, "altered": 11, "tested": 514, "note": null}, {"cohort": "glioma_mskcc_2019", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "ARID2", "kind": "SNV / small indel", "gene": "ARID2", "cells": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 2.14, "altered": 11, "tested": 514, "note": null}, {"cohort": "glioma_mskcc_2019", "status": "observed", "frequency": 4.33, "altered": 40, "tested": 924, "note": null}]}, {"label": "ANKRD30A", "kind": "SNV / small indel", "gene": "ANKRD30A", "cells": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 2.14, "altered": 11, "tested": 514, "note": null}, {"cohort": "glioma_mskcc_2019", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "ZAN", "kind": "SNV / small indel", "gene": "ZAN", "cells": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 1.95, "altered": 10, "tested": 514, "note": null}, {"cohort": "glioma_mskcc_2019", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "SPATA31E1", "kind": "SNV / small indel", "gene": "SPATA31E1", "cells": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 1.95, "altered": 10, "tested": 514, "note": null}, {"cohort": "glioma_mskcc_2019", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "SETD2", "kind": "SNV / small indel", "gene": "SETD2", "cells": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 1.95, "altered": 10, "tested": 514, "note": null}, {"cohort": "glioma_mskcc_2019", "status": "observed", "frequency": 5.41, "altered": 50, "tested": 924, "note": null}]}, {"label": "ROS1", "kind": "SNV / small indel", "gene": "ROS1", "cells": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 1.95, "altered": 10, "tested": 514, "note": null}, {"cohort": "glioma_mskcc_2019", "status": "observed", "frequency": 2.6, "altered": 24, "tested": 924, "note": null}]}, {"label": "MYO15A", "kind": "SNV / small indel", "gene": "MYO15A", "cells": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 1.95, "altered": 10, "tested": 514, "note": null}, {"cohort": "glioma_mskcc_2019", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "MYH1", "kind": "SNV / small indel", "gene": "MYH1", "cells": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 1.95, "altered": 10, "tested": 514, "note": null}, {"cohort": "glioma_mskcc_2019", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "ITIH6", "kind": "SNV / small indel", "gene": "ITIH6", "cells": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 1.95, "altered": 10, "tested": 514, "note": null}, {"cohort": "glioma_mskcc_2019", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "ITIH6", "kind": "amplification", "gene": "ITIH6", "cells": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 2.74, "altered": 14, "tested": 511, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "glioma_mskcc_2019", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 924, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "FLNC", "kind": "SNV / small indel", "gene": "FLNC", "cells": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 1.95, "altered": 10, "tested": 514, "note": null}, {"cohort": "glioma_mskcc_2019", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "EPPK1", "kind": "SNV / small indel", "gene": "EPPK1", "cells": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 1.95, "altered": 10, "tested": 514, "note": null}, {"cohort": "glioma_mskcc_2019", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "EPPK1", "kind": "amplification", "gene": "EPPK1", "cells": [{"cohort": "lgg_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.52, "altered": 18, "tested": 511, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "glioma_mskcc_2019", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 924, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}]}