{"disease": {"name": "Lung cancer", "mondo_id": null, "ncit_id": null, "umls_id": null, "oncotree_code": "luad"}, "updated_at": "2026-09-17", "genome_builds": ["hg19"], "cohort_count": 3, "cohort_count_status": "observed", "cohort_count_unit": "cohorts", "evaluable_patients": null, "evaluable_patients_status": "unknown", "evaluable_patients_unit": "patients", "alteration_types": ["SNV", "small indel", "amplification", "deep deletion"], "genes": [{"gene": "EGFR", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 69, "tested": 566, "frequency": 12.19, "cohort_count": 3, "frequency_range": {"min": 2.48, "max": 28.37}, "major_variants": ["L858R (n=23)", "E746_A750del (n=16)", "L861Q (n=3)", "E709_T710delinsD (n=3)", "L62R (n=2)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · TCGA PanCancer Atlas lung adenocarcinoma (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=luad_tcga_pan_can_atlas_2018", "source_record_id": "luad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · TCGA PanCancer Atlas lung squamous (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=lusc_tcga_pan_can_atlas_2018", "source_record_id": "lusc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · MSK-IMPACT non-small cell (Cancer Discov 2017)", "source_url": "https://www.cbioportal.org/study/summary?id=lung_msk_2017", "source_record_id": "lung_msk_2017", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: TCGA PanCancer Atlas lung adenocarcinoma (2018), 69/566 patients (12.19%).", "Without the 1 hypermutated patients: 69/565 (12.21%).", "Observed in 3 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "luad_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung adenocarcinoma (2018)", "altered": 69, "tested": 566, "frequency": 12.19, "frequency_excl_hypermutated": 12.21, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "566/566", "coverage_note": null, "source_id": "luad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung squamous (2018)", "altered": 12, "tested": 484, "frequency": 2.48, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "484/487", "coverage_note": null, "source_id": "lusc_tcga_pan_can_atlas_2018", "is_reference": false}, {"cohort": "lung_msk_2017", "cohort_name": "MSK-IMPACT non-small cell (Cancer Discov 2017)", "altered": 244, "tested": 860, "frequency": 28.37, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "915/915", "coverage_note": null, "source_id": "lung_msk_2017", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 8.27, "width": 86.3, "reference": 40.63, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 69, "tested": 566, "frequency": 12.19, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "ALK", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 34, "tested": 566, "frequency": 6.01, "cohort_count": 3, "frequency_range": {"min": 3.72, "max": 6.01}, "major_variants": ["V349F (n=1)", "L80M (n=1)", "T1102I (n=1)", "X263_splice (n=1)", "G263V (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · TCGA PanCancer Atlas lung adenocarcinoma (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=luad_tcga_pan_can_atlas_2018", "source_record_id": "luad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · TCGA PanCancer Atlas lung squamous (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=lusc_tcga_pan_can_atlas_2018", "source_record_id": "lusc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · MSK-IMPACT non-small cell (Cancer Discov 2017)", "source_url": "https://www.cbioportal.org/study/summary?id=lung_msk_2017", "source_record_id": "lung_msk_2017", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: TCGA PanCancer Atlas lung adenocarcinoma (2018), 34/566 patients (6.01%).", "Without the 1 hypermutated patients: 33/565 (5.84%).", "Observed in 3 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "luad_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung adenocarcinoma (2018)", "altered": 34, "tested": 566, "frequency": 6.01, "frequency_excl_hypermutated": 5.84, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "566/566", "coverage_note": null, "source_id": "luad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung squamous (2018)", "altered": 18, "tested": 484, "frequency": 3.72, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "484/487", "coverage_note": null, "source_id": "lusc_tcga_pan_can_atlas_2018", "is_reference": false}, {"cohort": "lung_msk_2017", "cohort_name": "MSK-IMPACT non-small cell (Cancer Discov 2017)", "altered": 39, "tested": 860, "frequency": 4.53, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "915/915", "coverage_note": null, "source_id": "lung_msk_2017", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 12.4, "width": 7.63, "reference": 20.03, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 34, "tested": 566, "frequency": 6.01, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "KRAS", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 168, "tested": 566, "frequency": 29.68, "cohort_count": 3, "frequency_range": {"min": 1.45, "max": 29.68}, "major_variants": ["G12C (n=70)", "G12V (n=40)", "G12D (n=20)", "G12A (n=17)", "G13C (n=7)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · TCGA PanCancer Atlas lung adenocarcinoma (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=luad_tcga_pan_can_atlas_2018", "source_record_id": "luad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · TCGA PanCancer Atlas lung squamous (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=lusc_tcga_pan_can_atlas_2018", "source_record_id": "lusc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · MSK-IMPACT non-small cell (Cancer Discov 2017)", "source_url": "https://www.cbioportal.org/study/summary?id=lung_msk_2017", "source_record_id": "lung_msk_2017", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: TCGA PanCancer Atlas lung adenocarcinoma (2018), 168/566 patients (29.68%).", "Without the 1 hypermutated patients: 168/565 (29.73%).", "Observed in 3 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "luad_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung adenocarcinoma (2018)", "altered": 168, "tested": 566, "frequency": 29.68, "frequency_excl_hypermutated": 29.73, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "566/566", "coverage_note": null, "source_id": "luad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung squamous (2018)", "altered": 7, "tested": 484, "frequency": 1.45, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "484/487", "coverage_note": null, "source_id": "lusc_tcga_pan_can_atlas_2018", "is_reference": false}, {"cohort": "lung_msk_2017", "cohort_name": "MSK-IMPACT non-small cell (Cancer Discov 2017)", "altered": 236, "tested": 860, "frequency": 27.44, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "915/915", "coverage_note": null, "source_id": "lung_msk_2017", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 4.83, "width": 94.1, "reference": 98.93, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 168, "tested": 566, "frequency": 29.68, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "ROS1", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 25, "tested": 566, "frequency": 4.42, "cohort_count": 3, "frequency_range": {"min": 1.98, "max": 7.64}, "major_variants": ["V797F (n=1)", "I1849M (n=1)", "M2275L (n=1)", "N267I (n=1)", "F2222L (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · TCGA PanCancer Atlas lung adenocarcinoma (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=luad_tcga_pan_can_atlas_2018", "source_record_id": "luad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · TCGA PanCancer Atlas lung squamous (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=lusc_tcga_pan_can_atlas_2018", "source_record_id": "lusc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · MSK-IMPACT non-small cell (Cancer Discov 2017)", "source_url": "https://www.cbioportal.org/study/summary?id=lung_msk_2017", "source_record_id": "lung_msk_2017", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: TCGA PanCancer Atlas lung adenocarcinoma (2018), 25/566 patients (4.42%).", "Without the 1 hypermutated patients: 24/565 (4.25%).", "Observed in 3 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "luad_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung adenocarcinoma (2018)", "altered": 25, "tested": 566, "frequency": 4.42, "frequency_excl_hypermutated": 4.25, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "566/566", "coverage_note": null, "source_id": "luad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung squamous (2018)", "altered": 37, "tested": 484, "frequency": 7.64, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "484/487", "coverage_note": null, "source_id": "lusc_tcga_pan_can_atlas_2018", "is_reference": false}, {"cohort": "lung_msk_2017", "cohort_name": "MSK-IMPACT non-small cell (Cancer Discov 2017)", "altered": 17, "tested": 860, "frequency": 1.98, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "915/915", "coverage_note": null, "source_id": "lung_msk_2017", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 6.6, "width": 18.87, "reference": 14.73, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 25, "tested": 566, "frequency": 4.42, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "BRAF", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 41, "tested": 566, "frequency": 7.24, "cohort_count": 3, "frequency_range": {"min": 3.1, "max": 7.24}, "major_variants": ["V600E (n=9)", "G469V (n=5)", "G466V (n=5)", "N581S (n=3)", "D594N (n=2)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · TCGA PanCancer Atlas lung adenocarcinoma (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=luad_tcga_pan_can_atlas_2018", "source_record_id": "luad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · TCGA PanCancer Atlas lung squamous (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=lusc_tcga_pan_can_atlas_2018", "source_record_id": "lusc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · MSK-IMPACT non-small cell (Cancer Discov 2017)", "source_url": "https://www.cbioportal.org/study/summary?id=lung_msk_2017", "source_record_id": "lung_msk_2017", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: TCGA PanCancer Atlas lung adenocarcinoma (2018), 41/566 patients (7.24%).", "Without the 1 hypermutated patients: 41/565 (7.26%).", "Observed in 3 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "luad_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung adenocarcinoma (2018)", "altered": 41, "tested": 566, "frequency": 7.24, "frequency_excl_hypermutated": 7.26, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "566/566", "coverage_note": null, "source_id": "luad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung squamous (2018)", "altered": 15, "tested": 484, "frequency": 3.1, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "484/487", "coverage_note": null, "source_id": "lusc_tcga_pan_can_atlas_2018", "is_reference": false}, {"cohort": "lung_msk_2017", "cohort_name": "MSK-IMPACT non-small cell (Cancer Discov 2017)", "altered": 50, "tested": 860, "frequency": 5.81, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "915/915", "coverage_note": null, "source_id": "lung_msk_2017", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 10.33, "width": 13.8, "reference": 24.13, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 41, "tested": 566, "frequency": 7.24, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "MET", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 21, "tested": 566, "frequency": 3.71, "cohort_count": 3, "frequency_range": {"min": 1.65, "max": 4.19}, "major_variants": ["X1010_splice (n=6)", "H476Y (n=1)", "R1279I (n=1)", "N315S (n=1)", "T660R (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · TCGA PanCancer Atlas lung adenocarcinoma (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=luad_tcga_pan_can_atlas_2018", "source_record_id": "luad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · TCGA PanCancer Atlas lung squamous (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=lusc_tcga_pan_can_atlas_2018", "source_record_id": "lusc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · MSK-IMPACT non-small cell (Cancer Discov 2017)", "source_url": "https://www.cbioportal.org/study/summary?id=lung_msk_2017", "source_record_id": "lung_msk_2017", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: TCGA PanCancer Atlas lung adenocarcinoma (2018), 21/566 patients (3.71%).", "Without the 1 hypermutated patients: 21/565 (3.72%).", "Observed in 3 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "luad_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung adenocarcinoma (2018)", "altered": 21, "tested": 566, "frequency": 3.71, "frequency_excl_hypermutated": 3.72, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "566/566", "coverage_note": null, "source_id": "luad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung squamous (2018)", "altered": 8, "tested": 484, "frequency": 1.65, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "484/487", "coverage_note": null, "source_id": "lusc_tcga_pan_can_atlas_2018", "is_reference": false}, {"cohort": "lung_msk_2017", "cohort_name": "MSK-IMPACT non-small cell (Cancer Discov 2017)", "altered": 36, "tested": 860, "frequency": 4.19, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "915/915", "coverage_note": null, "source_id": "lung_msk_2017", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 5.5, "width": 8.47, "reference": 12.37, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 21, "tested": 566, "frequency": 3.71, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "RET", "alteration_types": ["SNV / small indel", "deep deletion", "amplification"], "altered": 19, "tested": 566, "frequency": 3.36, "cohort_count": 3, "frequency_range": {"min": 2.67, "max": 3.36}, "major_variants": ["R77L (n=1)", "D290N (n=1)", "P560H (n=1)", "R494M (n=1)", "T350N (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · TCGA PanCancer Atlas lung adenocarcinoma (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=luad_tcga_pan_can_atlas_2018", "source_record_id": "luad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · TCGA PanCancer Atlas lung squamous (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=lusc_tcga_pan_can_atlas_2018", "source_record_id": "lusc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · MSK-IMPACT non-small cell (Cancer Discov 2017)", "source_url": "https://www.cbioportal.org/study/summary?id=lung_msk_2017", "source_record_id": "lung_msk_2017", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: TCGA PanCancer Atlas lung adenocarcinoma (2018), 19/566 patients (3.36%).", "Without the 1 hypermutated patients: 19/565 (3.36%).", "Observed in 3 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "luad_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung adenocarcinoma (2018)", "altered": 19, "tested": 566, "frequency": 3.36, "frequency_excl_hypermutated": 3.36, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "566/566", "coverage_note": null, "source_id": "luad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung squamous (2018)", "altered": 16, "tested": 484, "frequency": 3.31, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "484/487", "coverage_note": null, "source_id": "lusc_tcga_pan_can_atlas_2018", "is_reference": false}, {"cohort": "lung_msk_2017", "cohort_name": "MSK-IMPACT non-small cell (Cancer Discov 2017)", "altered": 23, "tested": 860, "frequency": 2.67, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "915/915", "coverage_note": null, "source_id": "lung_msk_2017", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 8.9, "width": 2.3, "reference": 11.2, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 19, "tested": 566, "frequency": 3.36, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "ERBB2", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 9, "tested": 566, "frequency": 1.59, "cohort_count": 3, "frequency_range": {"min": 1.59, "max": 4.19}, "major_variants": ["G776delinsVC (n=2)", "Y772_A775dup (n=2)", "X633_splice (n=1)", "L651V (n=1)", "S310F (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · TCGA PanCancer Atlas lung adenocarcinoma (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=luad_tcga_pan_can_atlas_2018", "source_record_id": "luad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · TCGA PanCancer Atlas lung squamous (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=lusc_tcga_pan_can_atlas_2018", "source_record_id": "lusc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · MSK-IMPACT non-small cell (Cancer Discov 2017)", "source_url": "https://www.cbioportal.org/study/summary?id=lung_msk_2017", "source_record_id": "lung_msk_2017", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: TCGA PanCancer Atlas lung adenocarcinoma (2018), 9/566 patients (1.59%).", "Without the 1 hypermutated patients: 9/565 (1.59%).", "Largest alteration is amplification: 9/511 (1.76%) in the reference cohort's copy-number profile.", "Observed in 3 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "luad_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung adenocarcinoma (2018)", "altered": 9, "tested": 566, "frequency": 1.59, "frequency_excl_hypermutated": 1.59, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "566/566", "coverage_note": null, "source_id": "luad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung squamous (2018)", "altered": 9, "tested": 484, "frequency": 1.86, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "484/487", "coverage_note": null, "source_id": "lusc_tcga_pan_can_atlas_2018", "is_reference": false}, {"cohort": "lung_msk_2017", "cohort_name": "MSK-IMPACT non-small cell (Cancer Discov 2017)", "altered": 36, "tested": 860, "frequency": 4.19, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "915/915", "coverage_note": null, "source_id": "lung_msk_2017", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 5.87, "width": 1.0, "reference": 5.87, "scale_max": 30.0}, "headline_alteration": {"kind": "amplification", "altered": 9, "tested": 511, "frequency": 1.76, "is_mutation": false}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "NTRK1", "alteration_types": ["SNV / small indel", "amplification"], "altered": 17, "tested": 566, "frequency": 3.0, "cohort_count": 3, "frequency_range": {"min": 2.21, "max": 3.0}, "major_variants": ["X501_splice (n=2)", "S477Y (n=1)", "R654H (n=1)", "F557Y (n=1)", "R649L (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · TCGA PanCancer Atlas lung adenocarcinoma (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=luad_tcga_pan_can_atlas_2018", "source_record_id": "luad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · TCGA PanCancer Atlas lung squamous (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=lusc_tcga_pan_can_atlas_2018", "source_record_id": "lusc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · MSK-IMPACT non-small cell (Cancer Discov 2017)", "source_url": "https://www.cbioportal.org/study/summary?id=lung_msk_2017", "source_record_id": "lung_msk_2017", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: TCGA PanCancer Atlas lung adenocarcinoma (2018), 17/566 patients (3.0%).", "Without the 1 hypermutated patients: 16/565 (2.83%).", "Largest alteration is amplification: 36/511 (7.05%) in the reference cohort's copy-number profile.", "Observed in 3 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "luad_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung adenocarcinoma (2018)", "altered": 17, "tested": 566, "frequency": 3.0, "frequency_excl_hypermutated": 2.83, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "566/566", "coverage_note": null, "source_id": "luad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung squamous (2018)", "altered": 12, "tested": 484, "frequency": 2.48, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "484/487", "coverage_note": null, "source_id": "lusc_tcga_pan_can_atlas_2018", "is_reference": false}, {"cohort": "lung_msk_2017", "cohort_name": "MSK-IMPACT non-small cell (Cancer Discov 2017)", "altered": 19, "tested": 860, "frequency": 2.21, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "915/915", "coverage_note": null, "source_id": "lung_msk_2017", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 23.5, "width": 1.0, "reference": 23.5, "scale_max": 30.0}, "headline_alteration": {"kind": "amplification", "altered": 36, "tested": 511, "frequency": 7.05, "is_mutation": false}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "TP53", "alteration_types": ["SNV / small indel", "deep deletion", "amplification"], "altered": 287, "tested": 566, "frequency": 50.71, "cohort_count": 3, "frequency_range": {"min": 50.71, "max": 81.4}, "major_variants": ["R273L (n=6)", "R158L (n=6)", "X126_splice (n=5)", "G245V (n=5)", "Y205C (n=4)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · TCGA PanCancer Atlas lung adenocarcinoma (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=luad_tcga_pan_can_atlas_2018", "source_record_id": "luad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · TCGA PanCancer Atlas lung squamous (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=lusc_tcga_pan_can_atlas_2018", "source_record_id": "lusc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · MSK-IMPACT non-small cell (Cancer Discov 2017)", "source_url": "https://www.cbioportal.org/study/summary?id=lung_msk_2017", "source_record_id": "lung_msk_2017", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: TCGA PanCancer Atlas lung adenocarcinoma (2018), 287/566 patients (50.71%).", "Without the 1 hypermutated patients: 286/565 (50.62%).", "Observed in 3 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "luad_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung adenocarcinoma (2018)", "altered": 287, "tested": 566, "frequency": 50.71, "frequency_excl_hypermutated": 50.62, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "566/566", "coverage_note": null, "source_id": "luad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung squamous (2018)", "altered": 394, "tested": 484, "frequency": 81.4, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "484/487", "coverage_note": null, "source_id": "lusc_tcga_pan_can_atlas_2018", "is_reference": false}, {"cohort": "lung_msk_2017", "cohort_name": "MSK-IMPACT non-small cell (Cancer Discov 2017)", "altered": 461, "tested": 860, "frequency": 53.6, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "915/915", "coverage_note": null, "source_id": "lung_msk_2017", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 100.0, "width": 1.0, "reference": 100.0, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 287, "tested": 566, "frequency": 50.71, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "STK11", "alteration_types": ["SNV / small indel", "deep deletion", "amplification"], "altered": 74, "tested": 566, "frequency": 13.07, "cohort_count": 3, "frequency_range": {"min": 1.03, "max": 17.56}, "major_variants": ["X155_splice (n=4)", "D53Tfs*11 (n=4)", "X245_splice (n=3)", "Y60* (n=3)", "G56W (n=2)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · TCGA PanCancer Atlas lung adenocarcinoma (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=luad_tcga_pan_can_atlas_2018", "source_record_id": "luad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · TCGA PanCancer Atlas lung squamous (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=lusc_tcga_pan_can_atlas_2018", "source_record_id": "lusc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · MSK-IMPACT non-small cell (Cancer Discov 2017)", "source_url": "https://www.cbioportal.org/study/summary?id=lung_msk_2017", "source_record_id": "lung_msk_2017", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: TCGA PanCancer Atlas lung adenocarcinoma (2018), 74/566 patients (13.07%).", "Without the 1 hypermutated patients: 74/565 (13.1%).", "Observed in 3 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "luad_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung adenocarcinoma (2018)", "altered": 74, "tested": 566, "frequency": 13.07, "frequency_excl_hypermutated": 13.1, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "566/566", "coverage_note": null, "source_id": "luad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung squamous (2018)", "altered": 5, "tested": 484, "frequency": 1.03, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "484/487", "coverage_note": null, "source_id": "lusc_tcga_pan_can_atlas_2018", "is_reference": false}, {"cohort": "lung_msk_2017", "cohort_name": "MSK-IMPACT non-small cell (Cancer Discov 2017)", "altered": 151, "tested": 860, "frequency": 17.56, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "915/915", "coverage_note": null, "source_id": "lung_msk_2017", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 3.43, "width": 55.1, "reference": 43.57, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 74, "tested": 566, "frequency": 13.07, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "KEAP1", "alteration_types": ["SNV / small indel", "deep deletion", "amplification"], "altered": 102, "tested": 566, "frequency": 18.02, "cohort_count": 3, "frequency_range": {"min": 10.12, "max": 18.02}, "major_variants": ["X570_splice (n=3)", "S144F (n=2)", "V271L (n=2)", "G333S (n=2)", "Q284L (n=2)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · TCGA PanCancer Atlas lung adenocarcinoma (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=luad_tcga_pan_can_atlas_2018", "source_record_id": "luad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · TCGA PanCancer Atlas lung squamous (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=lusc_tcga_pan_can_atlas_2018", "source_record_id": "lusc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · MSK-IMPACT non-small cell (Cancer Discov 2017)", "source_url": "https://www.cbioportal.org/study/summary?id=lung_msk_2017", "source_record_id": "lung_msk_2017", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: TCGA PanCancer Atlas lung adenocarcinoma (2018), 102/566 patients (18.02%).", "Without the 1 hypermutated patients: 102/565 (18.05%).", "Observed in 3 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "luad_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung adenocarcinoma (2018)", "altered": 102, "tested": 566, "frequency": 18.02, "frequency_excl_hypermutated": 18.05, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "566/566", "coverage_note": null, "source_id": "luad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung squamous (2018)", "altered": 49, "tested": 484, "frequency": 10.12, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "484/487", "coverage_note": null, "source_id": "lusc_tcga_pan_can_atlas_2018", "is_reference": false}, {"cohort": "lung_msk_2017", "cohort_name": "MSK-IMPACT non-small cell (Cancer Discov 2017)", "altered": 149, "tested": 860, "frequency": 17.33, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "915/915", "coverage_note": null, "source_id": "lung_msk_2017", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 33.73, "width": 26.34, "reference": 60.07, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 102, "tested": 566, "frequency": 18.02, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "CD274", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 4, "tested": 566, "frequency": 0.71, "cohort_count": 3, "frequency_range": {"min": 0.12, "max": 0.71}, "major_variants": ["S93Y (n=1)", "G110V (n=1)", "T277S (n=1)", "H233Y (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · TCGA PanCancer Atlas lung adenocarcinoma (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=luad_tcga_pan_can_atlas_2018", "source_record_id": "luad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · TCGA PanCancer Atlas lung squamous (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=lusc_tcga_pan_can_atlas_2018", "source_record_id": "lusc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · MSK-IMPACT non-small cell (Cancer Discov 2017)", "source_url": "https://www.cbioportal.org/study/summary?id=lung_msk_2017", "source_record_id": "lung_msk_2017", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: TCGA PanCancer Atlas lung adenocarcinoma (2018), 4/566 patients (0.71%).", "Without the 1 hypermutated patients: 4/565 (0.71%).", "Largest alteration is deep deletion: 10/511 (1.96%) in the reference cohort's copy-number profile.", "Observed in 3 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "luad_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung adenocarcinoma (2018)", "altered": 4, "tested": 566, "frequency": 0.71, "frequency_excl_hypermutated": 0.71, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "566/566", "coverage_note": null, "source_id": "luad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung squamous (2018)", "altered": 1, "tested": 484, "frequency": 0.21, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "484/487", "coverage_note": null, "source_id": "lusc_tcga_pan_can_atlas_2018", "is_reference": false}, {"cohort": "lung_msk_2017", "cohort_name": "MSK-IMPACT non-small cell (Cancer Discov 2017)", "altered": 1, "tested": 860, "frequency": 0.12, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "915/915", "coverage_note": null, "source_id": "lung_msk_2017", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 6.53, "width": 1.0, "reference": 6.53, "scale_max": 30.0}, "headline_alteration": {"kind": "deep deletion", "altered": 10, "tested": 511, "frequency": 1.96, "is_mutation": false}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "DLL3", "alteration_types": ["SNV / small indel", "amplification"], "altered": 6, "tested": 566, "frequency": 1.06, "cohort_count": 2, "frequency_range": {"min": 1.06, "max": 1.24}, "major_variants": ["M1? (n=1)", "R363C (n=1)", "L131F (n=1)", "G262V (n=1)", "G325C (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · TCGA PanCancer Atlas lung adenocarcinoma (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=luad_tcga_pan_can_atlas_2018", "source_record_id": "luad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · TCGA PanCancer Atlas lung squamous (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=lusc_tcga_pan_can_atlas_2018", "source_record_id": "lusc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · MSK-IMPACT non-small cell (Cancer Discov 2017)", "source_url": "https://www.cbioportal.org/study/summary?id=lung_msk_2017", "source_record_id": "lung_msk_2017", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: TCGA PanCancer Atlas lung adenocarcinoma (2018), 6/566 patients (1.06%).", "Without the 1 hypermutated patients: 6/565 (1.06%).", "Largest alteration is amplification: 7/511 (1.37%) in the reference cohort's copy-number profile.", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "luad_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung adenocarcinoma (2018)", "altered": 6, "tested": 566, "frequency": 1.06, "frequency_excl_hypermutated": 1.06, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "566/566", "coverage_note": null, "source_id": "luad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung squamous (2018)", "altered": 6, "tested": 484, "frequency": 1.24, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "484/487", "coverage_note": null, "source_id": "lusc_tcga_pan_can_atlas_2018", "is_reference": false}, {"cohort": "lung_msk_2017", "cohort_name": "MSK-IMPACT non-small cell (Cancer Discov 2017)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "915/915", "coverage_note": null, "source_id": "lung_msk_2017", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 4.57, "width": 1.0, "reference": 4.57, "scale_max": 30.0}, "headline_alteration": {"kind": "amplification", "altered": 7, "tested": 511, "frequency": 1.37, "is_mutation": false}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "NAV3", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 121, "tested": 566, "frequency": 21.38, "cohort_count": 2, "frequency_range": {"min": 21.28, "max": 21.38}, "major_variants": ["C579F (n=2)", "G5V (n=2)", "T1409S (n=2)", "R919M (n=1)", "T937N (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · TCGA PanCancer Atlas lung adenocarcinoma (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=luad_tcga_pan_can_atlas_2018", "source_record_id": "luad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · TCGA PanCancer Atlas lung squamous (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=lusc_tcga_pan_can_atlas_2018", "source_record_id": "lusc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · MSK-IMPACT non-small cell (Cancer Discov 2017)", "source_url": "https://www.cbioportal.org/study/summary?id=lung_msk_2017", "source_record_id": "lung_msk_2017", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: TCGA PanCancer Atlas lung adenocarcinoma (2018), 121/566 patients (21.38%).", "Without the 1 hypermutated patients: 120/565 (21.24%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "luad_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung adenocarcinoma (2018)", "altered": 121, "tested": 566, "frequency": 21.38, "frequency_excl_hypermutated": 21.24, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "566/566", "coverage_note": null, "source_id": "luad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung squamous (2018)", "altered": 103, "tested": 484, "frequency": 21.28, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "484/487", "coverage_note": null, "source_id": "lusc_tcga_pan_can_atlas_2018", "is_reference": false}, {"cohort": "lung_msk_2017", "cohort_name": "MSK-IMPACT non-small cell (Cancer Discov 2017)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "915/915", "coverage_note": null, "source_id": "lung_msk_2017", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 70.93, "width": 1.0, "reference": 71.27, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 121, "tested": 566, "frequency": 21.38, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "PCDH15", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 115, "tested": 566, "frequency": 20.32, "cohort_count": 2, "frequency_range": {"min": 19.21, "max": 20.32}, "major_variants": ["S1541N (n=2)", "G957* (n=2)", "R134Q (n=1)", "D1237Y (n=1)", "T1317N (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · TCGA PanCancer Atlas lung adenocarcinoma (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=luad_tcga_pan_can_atlas_2018", "source_record_id": "luad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · TCGA PanCancer Atlas lung squamous (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=lusc_tcga_pan_can_atlas_2018", "source_record_id": "lusc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · MSK-IMPACT non-small cell (Cancer Discov 2017)", "source_url": "https://www.cbioportal.org/study/summary?id=lung_msk_2017", "source_record_id": "lung_msk_2017", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: TCGA PanCancer Atlas lung adenocarcinoma (2018), 115/566 patients (20.32%).", "Without the 1 hypermutated patients: 114/565 (20.18%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "luad_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung adenocarcinoma (2018)", "altered": 115, "tested": 566, "frequency": 20.32, "frequency_excl_hypermutated": 20.18, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "566/566", "coverage_note": null, "source_id": "luad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung squamous (2018)", "altered": 93, "tested": 484, "frequency": 19.21, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "484/487", "coverage_note": null, "source_id": "lusc_tcga_pan_can_atlas_2018", "is_reference": false}, {"cohort": "lung_msk_2017", "cohort_name": "MSK-IMPACT non-small cell (Cancer Discov 2017)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "915/915", "coverage_note": null, "source_id": "lung_msk_2017", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 64.03, "width": 3.7, "reference": 67.73, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 115, "tested": 566, "frequency": 20.32, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "ADAMTS12", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 99, "tested": 566, "frequency": 17.49, "cohort_count": 2, "frequency_range": {"min": 16.74, "max": 17.49}, "major_variants": ["P1016Q (n=3)", "Y765C (n=2)", "G280W (n=2)", "V1448L (n=1)", "A1047E (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · TCGA PanCancer Atlas lung adenocarcinoma (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=luad_tcga_pan_can_atlas_2018", "source_record_id": "luad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · TCGA PanCancer Atlas lung squamous (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=lusc_tcga_pan_can_atlas_2018", "source_record_id": "lusc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · MSK-IMPACT non-small cell (Cancer Discov 2017)", "source_url": "https://www.cbioportal.org/study/summary?id=lung_msk_2017", "source_record_id": "lung_msk_2017", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: TCGA PanCancer Atlas lung adenocarcinoma (2018), 99/566 patients (17.49%).", "Without the 1 hypermutated patients: 99/565 (17.52%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "luad_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung adenocarcinoma (2018)", "altered": 99, "tested": 566, "frequency": 17.49, "frequency_excl_hypermutated": 17.52, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "566/566", "coverage_note": null, "source_id": "luad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung squamous (2018)", "altered": 81, "tested": 484, "frequency": 16.74, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "484/487", "coverage_note": null, "source_id": "lusc_tcga_pan_can_atlas_2018", "is_reference": false}, {"cohort": "lung_msk_2017", "cohort_name": "MSK-IMPACT non-small cell (Cancer Discov 2017)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "915/915", "coverage_note": null, "source_id": "lung_msk_2017", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 55.8, "width": 2.5, "reference": 58.3, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 99, "tested": 566, "frequency": 17.49, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "ADGRG4", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 98, "tested": 566, "frequency": 17.31, "cohort_count": 2, "frequency_range": {"min": 10.74, "max": 17.31}, "major_variants": ["C2914F (n=2)", "R3017L (n=2)", "P2881Q (n=2)", "T476K (n=2)", "V2188A (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · TCGA PanCancer Atlas lung adenocarcinoma (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=luad_tcga_pan_can_atlas_2018", "source_record_id": "luad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · TCGA PanCancer Atlas lung squamous (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=lusc_tcga_pan_can_atlas_2018", "source_record_id": "lusc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · MSK-IMPACT non-small cell (Cancer Discov 2017)", "source_url": "https://www.cbioportal.org/study/summary?id=lung_msk_2017", "source_record_id": "lung_msk_2017", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: TCGA PanCancer Atlas lung adenocarcinoma (2018), 98/566 patients (17.31%).", "Without the 1 hypermutated patients: 98/565 (17.35%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "luad_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung adenocarcinoma (2018)", "altered": 98, "tested": 566, "frequency": 17.31, "frequency_excl_hypermutated": 17.35, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "566/566", "coverage_note": null, "source_id": "luad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung squamous (2018)", "altered": 52, "tested": 484, "frequency": 10.74, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "484/487", "coverage_note": null, "source_id": "lusc_tcga_pan_can_atlas_2018", "is_reference": false}, {"cohort": "lung_msk_2017", "cohort_name": "MSK-IMPACT non-small cell (Cancer Discov 2017)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "915/915", "coverage_note": null, "source_id": "lung_msk_2017", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 35.8, "width": 21.9, "reference": 57.7, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 98, "tested": 566, "frequency": 17.31, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "TNR", "alteration_types": ["SNV / small indel", "amplification"], "altered": 95, "tested": 566, "frequency": 16.78, "cohort_count": 2, "frequency_range": {"min": 15.08, "max": 16.78}, "major_variants": ["R492L (n=2)", "X685_splice (n=2)", "S1050I (n=1)", "S200L (n=1)", "M832L (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · TCGA PanCancer Atlas lung adenocarcinoma (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=luad_tcga_pan_can_atlas_2018", "source_record_id": "luad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · TCGA PanCancer Atlas lung squamous (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=lusc_tcga_pan_can_atlas_2018", "source_record_id": "lusc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · MSK-IMPACT non-small cell (Cancer Discov 2017)", "source_url": "https://www.cbioportal.org/study/summary?id=lung_msk_2017", "source_record_id": "lung_msk_2017", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: TCGA PanCancer Atlas lung adenocarcinoma (2018), 95/566 patients (16.78%).", "Without the 1 hypermutated patients: 94/565 (16.64%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "luad_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung adenocarcinoma (2018)", "altered": 95, "tested": 566, "frequency": 16.78, "frequency_excl_hypermutated": 16.64, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "566/566", "coverage_note": null, "source_id": "luad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung squamous (2018)", "altered": 73, "tested": 484, "frequency": 15.08, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "484/487", "coverage_note": null, "source_id": "lusc_tcga_pan_can_atlas_2018", "is_reference": false}, {"cohort": "lung_msk_2017", "cohort_name": "MSK-IMPACT non-small cell (Cancer Discov 2017)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "915/915", "coverage_note": null, "source_id": "lung_msk_2017", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 50.27, "width": 5.66, "reference": 55.93, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 95, "tested": 566, "frequency": 16.78, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "SI", "alteration_types": ["SNV / small indel", "amplification"], "altered": 93, "tested": 566, "frequency": 16.43, "cohort_count": 2, "frequency_range": {"min": 16.43, "max": 17.36}, "major_variants": ["S1103* (n=2)", "I1343T (n=1)", "P57L (n=1)", "R1077L (n=1)", "Q670Rfs*20 (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · TCGA PanCancer Atlas lung adenocarcinoma (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=luad_tcga_pan_can_atlas_2018", "source_record_id": "luad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · TCGA PanCancer Atlas lung squamous (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=lusc_tcga_pan_can_atlas_2018", "source_record_id": "lusc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · MSK-IMPACT non-small cell (Cancer Discov 2017)", "source_url": "https://www.cbioportal.org/study/summary?id=lung_msk_2017", "source_record_id": "lung_msk_2017", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: TCGA PanCancer Atlas lung adenocarcinoma (2018), 93/566 patients (16.43%).", "Without the 1 hypermutated patients: 93/565 (16.46%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "luad_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung adenocarcinoma (2018)", "altered": 93, "tested": 566, "frequency": 16.43, "frequency_excl_hypermutated": 16.46, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "566/566", "coverage_note": null, "source_id": "luad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung squamous (2018)", "altered": 84, "tested": 484, "frequency": 17.36, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "484/487", "coverage_note": null, "source_id": "lusc_tcga_pan_can_atlas_2018", "is_reference": false}, {"cohort": "lung_msk_2017", "cohort_name": "MSK-IMPACT non-small cell (Cancer Discov 2017)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "915/915", "coverage_note": null, "source_id": "lung_msk_2017", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 54.77, "width": 3.1, "reference": 54.77, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 93, "tested": 566, "frequency": 16.43, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "NRXN1", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 92, "tested": 566, "frequency": 16.25, "cohort_count": 2, "frequency_range": {"min": 9.71, "max": 16.25}, "major_variants": ["A660S (n=2)", "P601T (n=2)", "G360* (n=2)", "G1188V (n=1)", "G409W (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · TCGA PanCancer Atlas lung adenocarcinoma (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=luad_tcga_pan_can_atlas_2018", "source_record_id": "luad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · TCGA PanCancer Atlas lung squamous (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=lusc_tcga_pan_can_atlas_2018", "source_record_id": "lusc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · MSK-IMPACT non-small cell (Cancer Discov 2017)", "source_url": "https://www.cbioportal.org/study/summary?id=lung_msk_2017", "source_record_id": "lung_msk_2017", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: TCGA PanCancer Atlas lung adenocarcinoma (2018), 92/566 patients (16.25%).", "Without the 1 hypermutated patients: 91/565 (16.11%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "luad_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung adenocarcinoma (2018)", "altered": 92, "tested": 566, "frequency": 16.25, "frequency_excl_hypermutated": 16.11, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "566/566", "coverage_note": null, "source_id": "luad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung squamous (2018)", "altered": 47, "tested": 484, "frequency": 9.71, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "484/487", "coverage_note": null, "source_id": "lusc_tcga_pan_can_atlas_2018", "is_reference": false}, {"cohort": "lung_msk_2017", "cohort_name": "MSK-IMPACT non-small cell (Cancer Discov 2017)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "915/915", "coverage_note": null, "source_id": "lung_msk_2017", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 32.37, "width": 21.8, "reference": 54.17, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 92, "tested": 566, "frequency": 16.25, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "PTPRD", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 91, "tested": 566, "frequency": 16.08, "cohort_count": 3, "frequency_range": {"min": 6.4, "max": 16.08}, "major_variants": ["A494S (n=2)", "V394I (n=1)", "L1255M (n=1)", "K1502* (n=1)", "Y1182F (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · TCGA PanCancer Atlas lung adenocarcinoma (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=luad_tcga_pan_can_atlas_2018", "source_record_id": "luad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · TCGA PanCancer Atlas lung squamous (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=lusc_tcga_pan_can_atlas_2018", "source_record_id": "lusc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · MSK-IMPACT non-small cell (Cancer Discov 2017)", "source_url": "https://www.cbioportal.org/study/summary?id=lung_msk_2017", "source_record_id": "lung_msk_2017", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: TCGA PanCancer Atlas lung adenocarcinoma (2018), 91/566 patients (16.08%).", "Without the 1 hypermutated patients: 90/565 (15.93%).", "Observed in 3 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "luad_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung adenocarcinoma (2018)", "altered": 91, "tested": 566, "frequency": 16.08, "frequency_excl_hypermutated": 15.93, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "566/566", "coverage_note": null, "source_id": "luad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung squamous (2018)", "altered": 31, "tested": 484, "frequency": 6.4, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "484/487", "coverage_note": null, "source_id": "lusc_tcga_pan_can_atlas_2018", "is_reference": false}, {"cohort": "lung_msk_2017", "cohort_name": "MSK-IMPACT non-small cell (Cancer Discov 2017)", "altered": 89, "tested": 860, "frequency": 10.35, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "915/915", "coverage_note": null, "source_id": "lung_msk_2017", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 21.33, "width": 32.27, "reference": 53.6, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 91, "tested": 566, "frequency": 16.08, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "CDH10", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 91, "tested": 566, "frequency": 16.08, "cohort_count": 2, "frequency_range": {"min": 16.08, "max": 19.63}, "major_variants": ["V406L (n=2)", "S577R (n=1)", "G99C (n=1)", "V174L (n=1)", "G754V (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · TCGA PanCancer Atlas lung adenocarcinoma (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=luad_tcga_pan_can_atlas_2018", "source_record_id": "luad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · TCGA PanCancer Atlas lung squamous (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=lusc_tcga_pan_can_atlas_2018", "source_record_id": "lusc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · MSK-IMPACT non-small cell (Cancer Discov 2017)", "source_url": "https://www.cbioportal.org/study/summary?id=lung_msk_2017", "source_record_id": "lung_msk_2017", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: TCGA PanCancer Atlas lung adenocarcinoma (2018), 91/566 patients (16.08%).", "Without the 1 hypermutated patients: 90/565 (15.93%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "luad_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung adenocarcinoma (2018)", "altered": 91, "tested": 566, "frequency": 16.08, "frequency_excl_hypermutated": 15.93, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "566/566", "coverage_note": null, "source_id": "luad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung squamous (2018)", "altered": 95, "tested": 484, "frequency": 19.63, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "484/487", "coverage_note": null, "source_id": "lusc_tcga_pan_can_atlas_2018", "is_reference": false}, {"cohort": "lung_msk_2017", "cohort_name": "MSK-IMPACT non-small cell (Cancer Discov 2017)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "915/915", "coverage_note": null, "source_id": "lung_msk_2017", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 53.6, "width": 11.83, "reference": 53.6, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 91, "tested": 566, "frequency": 16.08, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "NPAP1", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 87, "tested": 566, "frequency": 15.37, "cohort_count": 2, "frequency_range": {"min": 8.88, "max": 15.37}, "major_variants": ["R56L (n=2)", "P404T (n=1)", "S518Y (n=1)", "H39Q (n=1)", "V198L (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · TCGA PanCancer Atlas lung adenocarcinoma (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=luad_tcga_pan_can_atlas_2018", "source_record_id": "luad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · TCGA PanCancer Atlas lung squamous (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=lusc_tcga_pan_can_atlas_2018", "source_record_id": "lusc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · MSK-IMPACT non-small cell (Cancer Discov 2017)", "source_url": "https://www.cbioportal.org/study/summary?id=lung_msk_2017", "source_record_id": "lung_msk_2017", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: TCGA PanCancer Atlas lung adenocarcinoma (2018), 87/566 patients (15.37%).", "Without the 1 hypermutated patients: 86/565 (15.22%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "luad_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung adenocarcinoma (2018)", "altered": 87, "tested": 566, "frequency": 15.37, "frequency_excl_hypermutated": 15.22, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "566/566", "coverage_note": null, "source_id": "luad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung squamous (2018)", "altered": 43, "tested": 484, "frequency": 8.88, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "484/487", "coverage_note": null, "source_id": "lusc_tcga_pan_can_atlas_2018", "is_reference": false}, {"cohort": "lung_msk_2017", "cohort_name": "MSK-IMPACT non-small cell (Cancer Discov 2017)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "915/915", "coverage_note": null, "source_id": "lung_msk_2017", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 29.6, "width": 21.63, "reference": 51.23, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 87, "tested": 566, "frequency": 15.37, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "ERICH3", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 87, "tested": 566, "frequency": 15.37, "cohort_count": 2, "frequency_range": {"min": 15.37, "max": 17.36}, "major_variants": ["V431L (n=2)", "A12S (n=1)", "G1345V (n=1)", "M1320I (n=1)", "A949S (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most 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{"source_name": "cBioPortal · TCGA PanCancer Atlas lung squamous (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=lusc_tcga_pan_can_atlas_2018", "source_record_id": "lusc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · MSK-IMPACT non-small cell (Cancer Discov 2017)", "source_url": "https://www.cbioportal.org/study/summary?id=lung_msk_2017", "source_record_id": "lung_msk_2017", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use 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"status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "484/487", "coverage_note": null, "source_id": "lusc_tcga_pan_can_atlas_2018", "is_reference": false}, {"cohort": "lung_msk_2017", "cohort_name": "MSK-IMPACT non-small cell (Cancer Discov 2017)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "915/915", "coverage_note": null, "source_id": "lung_msk_2017", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 51.23, "width": 6.64, "reference": 51.23, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 87, "tested": 566, "frequency": 15.37, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "PXDNL", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 86, "tested": 566, "frequency": 15.19, "cohort_count": 2, "frequency_range": {"min": 10.54, "max": 15.19}, "major_variants": ["P1326T (n=2)", "M189I (n=1)", "H991N (n=1)", "E125Q (n=1)", "H269P (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · TCGA PanCancer Atlas lung 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TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · MSK-IMPACT non-small cell (Cancer Discov 2017)", "source_url": "https://www.cbioportal.org/study/summary?id=lung_msk_2017", "source_record_id": "lung_msk_2017", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: TCGA PanCancer Atlas lung adenocarcinoma (2018), 86/566 patients (15.19%).", "Without the 1 hypermutated patients: 86/565 (15.22%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "luad_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung adenocarcinoma (2018)", "altered": 86, "tested": 566, "frequency": 15.19, "frequency_excl_hypermutated": 15.22, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "566/566", "coverage_note": null, "source_id": "luad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung squamous (2018)", "altered": 51, "tested": 484, "frequency": 10.54, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "484/487", "coverage_note": null, "source_id": "lusc_tcga_pan_can_atlas_2018", "is_reference": false}, {"cohort": "lung_msk_2017", "cohort_name": "MSK-IMPACT non-small cell (Cancer Discov 2017)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene 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"observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "FAM135B", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 86, "tested": 566, "frequency": 15.19, "cohort_count": 2, "frequency_range": {"min": 15.19, "max": 24.38}, "major_variants": ["L359P (n=2)", "E481* (n=2)", "L937F (n=1)", "G674R (n=1)", "E756Q (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · TCGA PanCancer Atlas lung adenocarcinoma (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=luad_tcga_pan_can_atlas_2018", "source_record_id": "luad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · TCGA PanCancer Atlas lung squamous (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=lusc_tcga_pan_can_atlas_2018", "source_record_id": "lusc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · MSK-IMPACT non-small cell (Cancer Discov 2017)", "source_url": "https://www.cbioportal.org/study/summary?id=lung_msk_2017", "source_record_id": "lung_msk_2017", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: TCGA PanCancer Atlas lung adenocarcinoma (2018), 86/566 patients (15.19%).", "Without the 1 hypermutated patients: 85/565 (15.04%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "luad_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung 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"assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "915/915", "coverage_note": null, "source_id": "lung_msk_2017", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 50.63, "width": 30.64, "reference": 50.63, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 86, "tested": 566, "frequency": 15.19, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "CACNA1E", "alteration_types": ["SNV / small indel", "amplification"], "altered": 86, "tested": 566, "frequency": 15.19, "cohort_count": 2, "frequency_range": {"min": 9.92, "max": 15.19}, "major_variants": ["G133R (n=2)", "P1478L (n=1)", "A1720D (n=1)", "R1746H (n=1)", "L329M (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · TCGA PanCancer Atlas lung adenocarcinoma (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=luad_tcga_pan_can_atlas_2018", "source_record_id": "luad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · TCGA PanCancer Atlas lung squamous (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=lusc_tcga_pan_can_atlas_2018", "source_record_id": "lusc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · MSK-IMPACT non-small cell (Cancer Discov 2017)", "source_url": "https://www.cbioportal.org/study/summary?id=lung_msk_2017", "source_record_id": "lung_msk_2017", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: TCGA PanCancer Atlas lung adenocarcinoma (2018), 86/566 patients (15.19%).", "Without the 1 hypermutated patients: 85/565 (15.04%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "luad_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung adenocarcinoma (2018)", "altered": 86, "tested": 566, "frequency": 15.19, "frequency_excl_hypermutated": 15.04, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "566/566", "coverage_note": null, "source_id": "luad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung squamous (2018)", "altered": 48, "tested": 484, "frequency": 9.92, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "484/487", "coverage_note": null, "source_id": "lusc_tcga_pan_can_atlas_2018", "is_reference": false}, {"cohort": "lung_msk_2017", "cohort_name": "MSK-IMPACT non-small cell (Cancer Discov 2017)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "915/915", "coverage_note": null, "source_id": "lung_msk_2017", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 33.07, "width": 17.56, "reference": 50.63, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 86, "tested": 566, "frequency": 15.19, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "RELN", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 84, "tested": 566, "frequency": 14.84, "cohort_count": 2, "frequency_range": {"min": 14.84, "max": 15.91}, "major_variants": ["C3258* (n=1)", "D117E (n=1)", "C2543F (n=1)", "A909D (n=1)", "W2906* (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · TCGA PanCancer Atlas lung adenocarcinoma (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=luad_tcga_pan_can_atlas_2018", "source_record_id": "luad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · TCGA PanCancer Atlas lung squamous (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=lusc_tcga_pan_can_atlas_2018", "source_record_id": "lusc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · MSK-IMPACT non-small cell (Cancer Discov 2017)", "source_url": "https://www.cbioportal.org/study/summary?id=lung_msk_2017", "source_record_id": "lung_msk_2017", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: TCGA PanCancer Atlas lung adenocarcinoma (2018), 84/566 patients (14.84%).", "Without the 1 hypermutated patients: 83/565 (14.69%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "luad_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung adenocarcinoma (2018)", "altered": 84, "tested": 566, "frequency": 14.84, "frequency_excl_hypermutated": 14.69, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "566/566", "coverage_note": null, "source_id": "luad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung squamous (2018)", "altered": 77, "tested": 484, "frequency": 15.91, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "484/487", "coverage_note": null, "source_id": "lusc_tcga_pan_can_atlas_2018", "is_reference": false}, {"cohort": "lung_msk_2017", "cohort_name": "MSK-IMPACT non-small cell (Cancer Discov 2017)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "915/915", "coverage_note": null, "source_id": "lung_msk_2017", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 49.47, "width": 3.56, "reference": 49.47, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 84, "tested": 566, "frequency": 14.84, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "NALCN", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 84, "tested": 566, "frequency": 14.84, "cohort_count": 2, "frequency_range": {"min": 8.47, "max": 14.84}, "major_variants": ["E1234V (n=1)", "E1234D (n=1)", "G1013C (n=1)", "D1171Y (n=1)", "L148M (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · TCGA PanCancer Atlas lung adenocarcinoma (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=luad_tcga_pan_can_atlas_2018", "source_record_id": "luad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · TCGA PanCancer Atlas lung squamous (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=lusc_tcga_pan_can_atlas_2018", "source_record_id": "lusc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · MSK-IMPACT non-small cell (Cancer Discov 2017)", "source_url": "https://www.cbioportal.org/study/summary?id=lung_msk_2017", "source_record_id": "lung_msk_2017", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: TCGA PanCancer Atlas lung adenocarcinoma (2018), 84/566 patients (14.84%).", "Without the 1 hypermutated patients: 83/565 (14.69%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "luad_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung adenocarcinoma (2018)", "altered": 84, "tested": 566, "frequency": 14.84, "frequency_excl_hypermutated": 14.69, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "566/566", "coverage_note": null, "source_id": "luad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung squamous (2018)", "altered": 41, "tested": 484, "frequency": 8.47, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "484/487", "coverage_note": null, "source_id": "lusc_tcga_pan_can_atlas_2018", "is_reference": false}, {"cohort": "lung_msk_2017", "cohort_name": "MSK-IMPACT non-small cell (Cancer Discov 2017)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "915/915", "coverage_note": null, "source_id": "lung_msk_2017", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 28.23, "width": 21.24, "reference": 49.47, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 84, "tested": 566, "frequency": 14.84, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "LRRC7", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 83, "tested": 566, "frequency": 14.66, "cohort_count": 2, "frequency_range": {"min": 12.81, "max": 14.66}, "major_variants": ["W1270* (n=2)", "X103_splice (n=2)", "G1151V (n=1)", "A1373S (n=1)", "Q513H (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · TCGA PanCancer Atlas lung adenocarcinoma (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=luad_tcga_pan_can_atlas_2018", "source_record_id": "luad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · TCGA PanCancer Atlas lung squamous (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=lusc_tcga_pan_can_atlas_2018", "source_record_id": "lusc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · MSK-IMPACT non-small cell (Cancer Discov 2017)", "source_url": "https://www.cbioportal.org/study/summary?id=lung_msk_2017", "source_record_id": "lung_msk_2017", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: TCGA PanCancer Atlas lung adenocarcinoma (2018), 83/566 patients (14.66%).", "Without the 1 hypermutated patients: 83/565 (14.69%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "luad_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung adenocarcinoma (2018)", "altered": 83, "tested": 566, "frequency": 14.66, "frequency_excl_hypermutated": 14.69, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "566/566", "coverage_note": null, "source_id": "luad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung squamous (2018)", "altered": 62, "tested": 484, "frequency": 12.81, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "484/487", "coverage_note": null, "source_id": "lusc_tcga_pan_can_atlas_2018", "is_reference": false}, {"cohort": "lung_msk_2017", "cohort_name": "MSK-IMPACT non-small cell (Cancer Discov 2017)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "915/915", "coverage_note": null, "source_id": "lung_msk_2017", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 42.7, "width": 6.17, "reference": 48.87, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 83, "tested": 566, "frequency": 14.66, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "VCAN", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 81, "tested": 566, "frequency": 14.31, "cohort_count": 2, "frequency_range": {"min": 8.47, "max": 14.31}, "major_variants": ["D131Y (n=2)", "H2869D (n=1)", "T643I (n=1)", "D1382H (n=1)", "G2343A (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · TCGA PanCancer Atlas lung adenocarcinoma (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=luad_tcga_pan_can_atlas_2018", "source_record_id": "luad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · TCGA PanCancer Atlas lung squamous (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=lusc_tcga_pan_can_atlas_2018", "source_record_id": "lusc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · MSK-IMPACT non-small cell (Cancer Discov 2017)", "source_url": "https://www.cbioportal.org/study/summary?id=lung_msk_2017", "source_record_id": "lung_msk_2017", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: TCGA PanCancer Atlas lung adenocarcinoma (2018), 81/566 patients (14.31%).", "Without the 1 hypermutated patients: 81/565 (14.34%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "luad_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung adenocarcinoma (2018)", "altered": 81, "tested": 566, "frequency": 14.31, "frequency_excl_hypermutated": 14.34, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "566/566", "coverage_note": null, "source_id": "luad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung squamous (2018)", "altered": 41, "tested": 484, "frequency": 8.47, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "484/487", "coverage_note": null, "source_id": "lusc_tcga_pan_can_atlas_2018", "is_reference": false}, {"cohort": "lung_msk_2017", "cohort_name": "MSK-IMPACT non-small cell (Cancer Discov 2017)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "915/915", "coverage_note": null, "source_id": "lung_msk_2017", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 28.23, "width": 19.47, "reference": 47.7, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 81, "tested": 566, "frequency": 14.31, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "MXRA5", "alteration_types": ["SNV / small indel", "deep deletion", "amplification"], "altered": 81, "tested": 566, "frequency": 14.31, "cohort_count": 2, "frequency_range": {"min": 7.23, "max": 14.31}, "major_variants": ["P2674H (n=2)", "W1642L (n=1)", "S986* (n=1)", "R2668P (n=1)", "C33F (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · TCGA PanCancer Atlas lung adenocarcinoma (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=luad_tcga_pan_can_atlas_2018", "source_record_id": "luad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · TCGA PanCancer Atlas lung squamous (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=lusc_tcga_pan_can_atlas_2018", "source_record_id": "lusc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · MSK-IMPACT non-small cell (Cancer Discov 2017)", "source_url": "https://www.cbioportal.org/study/summary?id=lung_msk_2017", "source_record_id": "lung_msk_2017", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: TCGA PanCancer Atlas lung adenocarcinoma (2018), 81/566 patients (14.31%).", "Without the 1 hypermutated patients: 80/565 (14.16%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "luad_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung adenocarcinoma (2018)", "altered": 81, "tested": 566, "frequency": 14.31, "frequency_excl_hypermutated": 14.16, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "566/566", "coverage_note": null, "source_id": "luad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung squamous (2018)", "altered": 35, "tested": 484, "frequency": 7.23, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "484/487", "coverage_note": null, "source_id": "lusc_tcga_pan_can_atlas_2018", "is_reference": false}, {"cohort": "lung_msk_2017", "cohort_name": "MSK-IMPACT non-small cell (Cancer Discov 2017)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "915/915", "coverage_note": null, "source_id": "lung_msk_2017", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 24.1, "width": 23.6, "reference": 47.7, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 81, "tested": 566, "frequency": 14.31, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "ASTN1", "alteration_types": ["SNV / small indel", "amplification"], "altered": 80, "tested": 566, "frequency": 14.13, "cohort_count": 2, "frequency_range": {"min": 9.5, "max": 14.13}, "major_variants": ["P955T (n=2)", "G424V (n=1)", "G211R (n=1)", "R880* (n=1)", "D135Y (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · TCGA PanCancer Atlas lung adenocarcinoma (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=luad_tcga_pan_can_atlas_2018", "source_record_id": "luad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · TCGA PanCancer Atlas lung squamous (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=lusc_tcga_pan_can_atlas_2018", "source_record_id": "lusc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · MSK-IMPACT non-small cell (Cancer Discov 2017)", "source_url": "https://www.cbioportal.org/study/summary?id=lung_msk_2017", "source_record_id": "lung_msk_2017", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: TCGA PanCancer Atlas lung adenocarcinoma (2018), 80/566 patients (14.13%).", "Without the 1 hypermutated patients: 79/565 (13.98%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "luad_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung adenocarcinoma (2018)", "altered": 80, "tested": 566, "frequency": 14.13, "frequency_excl_hypermutated": 13.98, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "566/566", "coverage_note": null, "source_id": "luad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung squamous (2018)", "altered": 46, "tested": 484, "frequency": 9.5, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "484/487", "coverage_note": null, "source_id": "lusc_tcga_pan_can_atlas_2018", "is_reference": false}, {"cohort": "lung_msk_2017", "cohort_name": "MSK-IMPACT non-small cell (Cancer Discov 2017)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "915/915", "coverage_note": null, "source_id": "lung_msk_2017", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 31.67, "width": 15.43, "reference": 47.1, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 80, "tested": 566, "frequency": 14.13, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "PRDM9", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 79, "tested": 566, "frequency": 13.96, "cohort_count": 2, "frequency_range": {"min": 13.96, "max": 14.26}, "major_variants": ["M43I (n=2)", "H826Q (n=2)", "H826N (n=1)", "X294_splice (n=1)", "E780D (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · TCGA PanCancer Atlas lung adenocarcinoma (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=luad_tcga_pan_can_atlas_2018", "source_record_id": "luad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · TCGA PanCancer Atlas lung squamous (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=lusc_tcga_pan_can_atlas_2018", "source_record_id": "lusc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · MSK-IMPACT non-small cell (Cancer Discov 2017)", "source_url": "https://www.cbioportal.org/study/summary?id=lung_msk_2017", "source_record_id": "lung_msk_2017", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: TCGA PanCancer Atlas lung adenocarcinoma (2018), 79/566 patients (13.96%).", "Without the 1 hypermutated patients: 79/565 (13.98%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "luad_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung adenocarcinoma (2018)", "altered": 79, "tested": 566, "frequency": 13.96, "frequency_excl_hypermutated": 13.98, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "566/566", "coverage_note": null, "source_id": "luad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung squamous (2018)", "altered": 69, "tested": 484, "frequency": 14.26, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "484/487", "coverage_note": null, "source_id": "lusc_tcga_pan_can_atlas_2018", "is_reference": false}, {"cohort": "lung_msk_2017", "cohort_name": "MSK-IMPACT non-small cell (Cancer Discov 2017)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "915/915", "coverage_note": null, "source_id": "lung_msk_2017", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 46.53, "width": 1.0, "reference": 46.53, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 79, "tested": 566, "frequency": 13.96, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "KMT2C", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 76, "tested": 566, "frequency": 13.43, "cohort_count": 3, "frequency_range": {"min": 6.16, "max": 14.67}, "major_variants": ["Q356K (n=2)", "W383L (n=2)", "Q384E (n=1)", "L378V (n=1)", "C302F (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · TCGA PanCancer Atlas lung adenocarcinoma (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=luad_tcga_pan_can_atlas_2018", "source_record_id": "luad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · TCGA PanCancer Atlas lung squamous (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=lusc_tcga_pan_can_atlas_2018", "source_record_id": "lusc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · MSK-IMPACT non-small cell (Cancer Discov 2017)", "source_url": "https://www.cbioportal.org/study/summary?id=lung_msk_2017", "source_record_id": "lung_msk_2017", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: TCGA PanCancer Atlas lung adenocarcinoma (2018), 76/566 patients (13.43%).", "Without the 1 hypermutated patients: 75/565 (13.27%).", "Observed in 3 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "luad_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung adenocarcinoma (2018)", "altered": 76, "tested": 566, "frequency": 13.43, "frequency_excl_hypermutated": 13.27, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "566/566", "coverage_note": null, "source_id": "luad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung squamous (2018)", "altered": 71, "tested": 484, "frequency": 14.67, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "484/487", "coverage_note": null, "source_id": "lusc_tcga_pan_can_atlas_2018", "is_reference": false}, {"cohort": "lung_msk_2017", "cohort_name": "MSK-IMPACT non-small cell (Cancer Discov 2017)", "altered": 53, "tested": 860, "frequency": 6.16, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "915/915", "coverage_note": null, "source_id": "lung_msk_2017", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 20.53, "width": 28.37, "reference": 44.77, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 76, "tested": 566, "frequency": 13.43, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "ASXL3", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 75, "tested": 566, "frequency": 13.25, "cohort_count": 2, "frequency_range": {"min": 7.64, "max": 13.25}, "major_variants": ["P1470Q (n=2)", "P849T (n=2)", "N377K (n=1)", "S1736* (n=1)", "P1799Q (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · TCGA PanCancer Atlas lung adenocarcinoma (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=luad_tcga_pan_can_atlas_2018", "source_record_id": "luad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · TCGA PanCancer Atlas lung squamous (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=lusc_tcga_pan_can_atlas_2018", "source_record_id": "lusc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · MSK-IMPACT non-small cell (Cancer Discov 2017)", "source_url": "https://www.cbioportal.org/study/summary?id=lung_msk_2017", "source_record_id": "lung_msk_2017", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: TCGA PanCancer Atlas lung adenocarcinoma (2018), 75/566 patients (13.25%).", "Without the 1 hypermutated patients: 75/565 (13.27%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "luad_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung adenocarcinoma (2018)", "altered": 75, "tested": 566, "frequency": 13.25, "frequency_excl_hypermutated": 13.27, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "566/566", "coverage_note": null, "source_id": "luad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung squamous (2018)", "altered": 37, "tested": 484, "frequency": 7.64, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "484/487", "coverage_note": null, "source_id": "lusc_tcga_pan_can_atlas_2018", "is_reference": false}, {"cohort": "lung_msk_2017", "cohort_name": "MSK-IMPACT non-small cell (Cancer Discov 2017)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "915/915", "coverage_note": null, "source_id": "lung_msk_2017", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 25.47, "width": 18.7, "reference": 44.17, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 75, "tested": 566, "frequency": 13.25, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "ASPM", "alteration_types": ["SNV / small indel", "amplification"], "altered": 75, "tested": 566, "frequency": 13.25, "cohort_count": 2, "frequency_range": {"min": 8.68, "max": 13.25}, "major_variants": ["E1026V (n=1)", "K1746Q (n=1)", "K1789T (n=1)", "Q1173P (n=1)", "Y2564C (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · TCGA PanCancer Atlas lung adenocarcinoma (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=luad_tcga_pan_can_atlas_2018", "source_record_id": "luad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · TCGA PanCancer Atlas lung squamous (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=lusc_tcga_pan_can_atlas_2018", "source_record_id": "lusc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · MSK-IMPACT non-small cell (Cancer Discov 2017)", "source_url": "https://www.cbioportal.org/study/summary?id=lung_msk_2017", "source_record_id": "lung_msk_2017", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: TCGA PanCancer Atlas lung adenocarcinoma (2018), 75/566 patients (13.25%).", "Without the 1 hypermutated patients: 75/565 (13.27%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "luad_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung adenocarcinoma (2018)", "altered": 75, "tested": 566, "frequency": 13.25, "frequency_excl_hypermutated": 13.27, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "566/566", "coverage_note": null, "source_id": "luad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung squamous (2018)", "altered": 42, "tested": 484, "frequency": 8.68, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "484/487", "coverage_note": null, "source_id": "lusc_tcga_pan_can_atlas_2018", "is_reference": false}, {"cohort": "lung_msk_2017", "cohort_name": "MSK-IMPACT non-small cell (Cancer Discov 2017)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "915/915", "coverage_note": null, "source_id": "lung_msk_2017", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 28.93, "width": 15.24, "reference": 44.17, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 75, "tested": 566, "frequency": 13.25, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "PKHD1", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 74, "tested": 566, "frequency": 13.07, "cohort_count": 2, "frequency_range": {"min": 13.07, "max": 17.77}, "major_variants": ["R2714L (n=2)", "P3850S (n=1)", "G725V (n=1)", "S3570L (n=1)", "C2368F (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · TCGA PanCancer Atlas lung adenocarcinoma (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=luad_tcga_pan_can_atlas_2018", "source_record_id": "luad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · TCGA PanCancer Atlas lung squamous (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=lusc_tcga_pan_can_atlas_2018", "source_record_id": "lusc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · MSK-IMPACT non-small cell (Cancer Discov 2017)", "source_url": "https://www.cbioportal.org/study/summary?id=lung_msk_2017", "source_record_id": "lung_msk_2017", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: TCGA PanCancer Atlas lung adenocarcinoma (2018), 74/566 patients (13.07%).", "Without the 1 hypermutated patients: 74/565 (13.1%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "luad_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung adenocarcinoma (2018)", "altered": 74, "tested": 566, "frequency": 13.07, "frequency_excl_hypermutated": 13.1, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "566/566", "coverage_note": null, "source_id": "luad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung squamous (2018)", "altered": 86, "tested": 484, "frequency": 17.77, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "484/487", "coverage_note": null, "source_id": "lusc_tcga_pan_can_atlas_2018", "is_reference": false}, {"cohort": "lung_msk_2017", "cohort_name": "MSK-IMPACT non-small cell (Cancer Discov 2017)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "915/915", "coverage_note": null, "source_id": "lung_msk_2017", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 43.57, "width": 15.66, "reference": 43.57, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 74, "tested": 566, "frequency": 13.07, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "HRNR", "alteration_types": ["SNV / small indel", "amplification"], "altered": 74, "tested": 566, "frequency": 13.07, "cohort_count": 2, "frequency_range": {"min": 6.61, "max": 13.07}, "major_variants": ["G440C (n=2)", "G2206V (n=2)", "G458C (n=2)", "H610N (n=1)", "S2036* (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · TCGA PanCancer Atlas lung adenocarcinoma (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=luad_tcga_pan_can_atlas_2018", "source_record_id": "luad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · TCGA PanCancer Atlas lung squamous (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=lusc_tcga_pan_can_atlas_2018", "source_record_id": "lusc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · MSK-IMPACT non-small cell (Cancer Discov 2017)", "source_url": "https://www.cbioportal.org/study/summary?id=lung_msk_2017", "source_record_id": "lung_msk_2017", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: TCGA PanCancer Atlas lung adenocarcinoma (2018), 74/566 patients (13.07%).", "Without the 1 hypermutated patients: 73/565 (12.92%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "luad_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung adenocarcinoma (2018)", "altered": 74, "tested": 566, "frequency": 13.07, "frequency_excl_hypermutated": 12.92, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "566/566", "coverage_note": null, "source_id": "luad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung squamous (2018)", "altered": 32, "tested": 484, "frequency": 6.61, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "484/487", "coverage_note": null, "source_id": "lusc_tcga_pan_can_atlas_2018", "is_reference": false}, {"cohort": "lung_msk_2017", "cohort_name": "MSK-IMPACT non-small cell (Cancer Discov 2017)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "915/915", "coverage_note": null, "source_id": "lung_msk_2017", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 22.03, "width": 21.54, "reference": 43.57, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 74, "tested": 566, "frequency": 13.07, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "TSHZ3", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 73, "tested": 566, "frequency": 12.9, "cohort_count": 2, "frequency_range": {"min": 5.37, "max": 12.9}, "major_variants": ["G677W (n=2)", "G940V (n=2)", "V480F (n=2)", "W544* (n=1)", "D166G (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · TCGA PanCancer Atlas lung adenocarcinoma (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=luad_tcga_pan_can_atlas_2018", "source_record_id": "luad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · TCGA PanCancer Atlas lung squamous (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=lusc_tcga_pan_can_atlas_2018", "source_record_id": "lusc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · MSK-IMPACT non-small cell (Cancer Discov 2017)", "source_url": "https://www.cbioportal.org/study/summary?id=lung_msk_2017", "source_record_id": "lung_msk_2017", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: TCGA PanCancer Atlas lung adenocarcinoma (2018), 73/566 patients (12.9%).", "Without the 1 hypermutated patients: 72/565 (12.74%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "luad_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung adenocarcinoma (2018)", "altered": 73, "tested": 566, "frequency": 12.9, "frequency_excl_hypermutated": 12.74, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "566/566", "coverage_note": null, "source_id": "luad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung squamous (2018)", "altered": 26, "tested": 484, "frequency": 5.37, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "484/487", "coverage_note": null, "source_id": "lusc_tcga_pan_can_atlas_2018", "is_reference": false}, {"cohort": "lung_msk_2017", "cohort_name": "MSK-IMPACT non-small cell (Cancer Discov 2017)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "915/915", "coverage_note": null, "source_id": "lung_msk_2017", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 17.9, "width": 25.1, "reference": 43.0, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 73, "tested": 566, "frequency": 12.9, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "TNN", "alteration_types": ["SNV / small indel", "amplification"], "altered": 73, "tested": 566, "frequency": 12.9, "cohort_count": 2, "frequency_range": {"min": 12.19, "max": 12.9}, "major_variants": ["Q759H (n=2)", "V688L (n=2)", "S744F (n=2)", "S921F (n=1)", "R927S (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · TCGA PanCancer Atlas lung adenocarcinoma (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=luad_tcga_pan_can_atlas_2018", "source_record_id": "luad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · TCGA PanCancer Atlas lung squamous (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=lusc_tcga_pan_can_atlas_2018", "source_record_id": "lusc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · MSK-IMPACT non-small cell (Cancer Discov 2017)", "source_url": "https://www.cbioportal.org/study/summary?id=lung_msk_2017", "source_record_id": "lung_msk_2017", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: TCGA PanCancer Atlas lung adenocarcinoma (2018), 73/566 patients (12.9%).", "Without the 1 hypermutated patients: 72/565 (12.74%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "luad_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung adenocarcinoma (2018)", "altered": 73, "tested": 566, "frequency": 12.9, "frequency_excl_hypermutated": 12.74, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "566/566", "coverage_note": null, "source_id": "luad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung squamous (2018)", "altered": 59, "tested": 484, "frequency": 12.19, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "484/487", "coverage_note": null, "source_id": "lusc_tcga_pan_can_atlas_2018", "is_reference": false}, {"cohort": "lung_msk_2017", "cohort_name": "MSK-IMPACT non-small cell (Cancer Discov 2017)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "915/915", "coverage_note": null, "source_id": "lung_msk_2017", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 40.63, "width": 2.37, "reference": 43.0, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 73, "tested": 566, "frequency": 12.9, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "PEG3", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 73, "tested": 566, "frequency": 12.9, "cohort_count": 2, "frequency_range": {"min": 12.81, "max": 12.9}, "major_variants": ["L234F (n=1)", "P1425S (n=1)", "P1425R (n=1)", "Q582K (n=1)", "G1222V (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · TCGA PanCancer Atlas lung adenocarcinoma (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=luad_tcga_pan_can_atlas_2018", "source_record_id": "luad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · TCGA PanCancer Atlas lung squamous (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=lusc_tcga_pan_can_atlas_2018", "source_record_id": "lusc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · MSK-IMPACT non-small cell (Cancer Discov 2017)", "source_url": "https://www.cbioportal.org/study/summary?id=lung_msk_2017", "source_record_id": "lung_msk_2017", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: TCGA PanCancer Atlas lung adenocarcinoma (2018), 73/566 patients (12.9%).", "Without the 1 hypermutated patients: 72/565 (12.74%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "luad_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung adenocarcinoma (2018)", "altered": 73, "tested": 566, "frequency": 12.9, "frequency_excl_hypermutated": 12.74, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "566/566", "coverage_note": null, "source_id": "luad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung squamous (2018)", "altered": 62, "tested": 484, "frequency": 12.81, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "484/487", "coverage_note": null, "source_id": "lusc_tcga_pan_can_atlas_2018", "is_reference": false}, {"cohort": "lung_msk_2017", "cohort_name": "MSK-IMPACT non-small cell (Cancer Discov 2017)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "915/915", "coverage_note": null, "source_id": "lung_msk_2017", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 42.7, "width": 1.0, "reference": 43.0, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 73, "tested": 566, "frequency": 12.9, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "RIMS2", "alteration_types": ["SNV / small indel", "amplification"], "altered": 72, "tested": 566, "frequency": 12.72, "cohort_count": 2, "frequency_range": {"min": 7.85, "max": 12.72}, "major_variants": ["R332L (n=2)", "Y320* (n=2)", "A340S (n=2)", "P881H (n=1)", "A17D (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · TCGA PanCancer Atlas lung adenocarcinoma (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=luad_tcga_pan_can_atlas_2018", "source_record_id": "luad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · TCGA PanCancer Atlas lung squamous (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=lusc_tcga_pan_can_atlas_2018", "source_record_id": "lusc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · MSK-IMPACT non-small cell (Cancer Discov 2017)", "source_url": "https://www.cbioportal.org/study/summary?id=lung_msk_2017", "source_record_id": "lung_msk_2017", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: TCGA PanCancer Atlas lung adenocarcinoma (2018), 72/566 patients (12.72%).", "Without the 1 hypermutated patients: 71/565 (12.57%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "luad_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung adenocarcinoma (2018)", "altered": 72, "tested": 566, "frequency": 12.72, "frequency_excl_hypermutated": 12.57, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "566/566", "coverage_note": null, "source_id": "luad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung squamous (2018)", "altered": 38, "tested": 484, "frequency": 7.85, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "484/487", "coverage_note": null, "source_id": "lusc_tcga_pan_can_atlas_2018", "is_reference": false}, {"cohort": "lung_msk_2017", "cohort_name": "MSK-IMPACT non-small cell (Cancer Discov 2017)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "915/915", "coverage_note": null, "source_id": "lung_msk_2017", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 26.17, "width": 16.23, "reference": 42.4, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 72, "tested": 566, "frequency": 12.72, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "LAMA2", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 72, "tested": 566, "frequency": 12.72, "cohort_count": 2, "frequency_range": {"min": 12.72, "max": 13.64}, "major_variants": ["C1429F (n=1)", "D3062E (n=1)", "G1457R (n=1)", "L2284M (n=1)", "R1285I (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · TCGA PanCancer Atlas lung adenocarcinoma (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=luad_tcga_pan_can_atlas_2018", "source_record_id": "luad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · TCGA PanCancer Atlas lung squamous (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=lusc_tcga_pan_can_atlas_2018", "source_record_id": "lusc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · MSK-IMPACT non-small cell (Cancer Discov 2017)", "source_url": "https://www.cbioportal.org/study/summary?id=lung_msk_2017", "source_record_id": "lung_msk_2017", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: TCGA PanCancer Atlas lung adenocarcinoma (2018), 72/566 patients (12.72%).", "Without the 1 hypermutated patients: 71/565 (12.57%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "luad_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung adenocarcinoma (2018)", "altered": 72, "tested": 566, "frequency": 12.72, "frequency_excl_hypermutated": 12.57, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "566/566", "coverage_note": null, "source_id": "luad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung squamous (2018)", "altered": 66, "tested": 484, "frequency": 13.64, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "484/487", "coverage_note": null, "source_id": "lusc_tcga_pan_can_atlas_2018", "is_reference": false}, {"cohort": "lung_msk_2017", "cohort_name": "MSK-IMPACT non-small cell (Cancer Discov 2017)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "915/915", "coverage_note": null, "source_id": "lung_msk_2017", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 42.4, "width": 3.07, "reference": 42.4, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 72, "tested": 566, "frequency": 12.72, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "BRINP3", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 72, "tested": 566, "frequency": 12.72, "cohort_count": 2, "frequency_range": {"min": 12.72, "max": 13.64}, "major_variants": ["L565F (n=2)", "L683M (n=2)", "E566* (n=1)", "T692N (n=1)", "Q747P (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · TCGA PanCancer Atlas lung adenocarcinoma (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=luad_tcga_pan_can_atlas_2018", "source_record_id": "luad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · TCGA PanCancer Atlas lung squamous (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=lusc_tcga_pan_can_atlas_2018", "source_record_id": "lusc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · MSK-IMPACT non-small cell (Cancer Discov 2017)", "source_url": "https://www.cbioportal.org/study/summary?id=lung_msk_2017", "source_record_id": "lung_msk_2017", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: TCGA PanCancer Atlas lung adenocarcinoma (2018), 72/566 patients (12.72%).", "Without the 1 hypermutated patients: 72/565 (12.74%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "luad_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung adenocarcinoma (2018)", "altered": 72, "tested": 566, "frequency": 12.72, "frequency_excl_hypermutated": 12.74, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "566/566", "coverage_note": null, "source_id": "luad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "cohort_name": "TCGA PanCancer Atlas lung squamous (2018)", "altered": 66, "tested": 484, "frequency": 13.64, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "484/487", "coverage_note": null, "source_id": "lusc_tcga_pan_can_atlas_2018", "is_reference": false}, {"cohort": "lung_msk_2017", "cohort_name": "MSK-IMPACT non-small cell (Cancer Discov 2017)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on 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"moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · TCGA PanCancer Atlas lung adenocarcinoma (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=luad_tcga_pan_can_atlas_2018", "source_record_id": "luad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; 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"moderate", "details": null}, {"event_type": "copy_number", "gene": "HRNR", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "HRNR amplification", "genomic_coordinate": null, "observed": 21, "observed_status": "observed", "observed_unit": "patients", "tested": 487, "tested_status": "observed", "tested_unit": "patients", "frequency": 4.31, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["lusc_tcga_pan_can_atlas_2018"], "source_ids": ["lusc_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "TSHZ3", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "TSHZ3 amplification", "genomic_coordinate": null, "observed": 21, "observed_status": "observed", "observed_unit": "patients", "tested": 487, "tested_status": "observed", "tested_unit": "patients", "frequency": 4.31, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["lusc_tcga_pan_can_atlas_2018"], "source_ids": ["lusc_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "TNR", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "TNR amplification", "genomic_coordinate": null, "observed": 19, "observed_status": "observed", "observed_unit": "patients", "tested": 487, "tested_status": "observed", "tested_unit": "patients", "frequency": 3.9, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["lusc_tcga_pan_can_atlas_2018"], "source_ids": ["lusc_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "TNN", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "TNN amplification", "genomic_coordinate": null, "observed": 18, "observed_status": "observed", "observed_unit": "patients", "tested": 487, "tested_status": "observed", "tested_unit": "patients", "frequency": 3.7, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["lusc_tcga_pan_can_atlas_2018"], "source_ids": ["lusc_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "ASTN1", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "ASTN1 amplification", "genomic_coordinate": null, "observed": 18, "observed_status": "observed", "observed_unit": "patients", "tested": 511, "tested_status": "observed", "tested_unit": "patients", "frequency": 3.52, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["luad_tcga_pan_can_atlas_2018"], "source_ids": ["luad_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "TNN", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "TNN amplification", "genomic_coordinate": null, "observed": 18, "observed_status": "observed", "observed_unit": "patients", "tested": 511, "tested_status": "observed", "tested_unit": "patients", "frequency": 3.52, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["luad_tcga_pan_can_atlas_2018"], "source_ids": ["luad_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "ASTN1", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "ASTN1 amplification", "genomic_coordinate": null, "observed": 17, "observed_status": "observed", "observed_unit": "patients", "tested": 487, "tested_status": "observed", "tested_unit": "patients", "frequency": 3.49, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["lusc_tcga_pan_can_atlas_2018"], "source_ids": ["lusc_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "RIMS2", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "RIMS2 amplification", "genomic_coordinate": null, "observed": 17, "observed_status": "observed", "observed_unit": "patients", "tested": 487, "tested_status": "observed", "tested_unit": "patients", "frequency": 3.49, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["lusc_tcga_pan_can_atlas_2018"], "source_ids": ["lusc_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "ERBB2", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "ERBB2 amplification", "genomic_coordinate": null, "observed": 29, "observed_status": "observed", "observed_unit": "patients", "tested": 860, "tested_status": "observed", "tested_unit": "patients", "frequency": 3.37, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["lung_msk_2017"], "source_ids": ["lung_msk_2017_cna"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "TNR", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "TNR amplification", "genomic_coordinate": null, "observed": 17, "observed_status": "observed", "observed_unit": "patients", "tested": 511, "tested_status": "observed", "tested_unit": "patients", "frequency": 3.33, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["luad_tcga_pan_can_atlas_2018"], "source_ids": ["luad_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "ASPM", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "ASPM amplification", "genomic_coordinate": null, "observed": 17, "observed_status": "observed", "observed_unit": "patients", "tested": 511, "tested_status": "observed", "tested_unit": "patients", "frequency": 3.33, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["luad_tcga_pan_can_atlas_2018"], "source_ids": ["luad_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "NTRK1", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "NTRK1 amplification", "genomic_coordinate": null, "observed": 16, "observed_status": "observed", "observed_unit": "patients", "tested": 487, "tested_status": "observed", "tested_unit": "patients", "frequency": 3.29, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["lusc_tcga_pan_can_atlas_2018"], "source_ids": ["lusc_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "RELN", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "RELN amplification", "genomic_coordinate": null, "observed": 16, "observed_status": "observed", "observed_unit": "patients", "tested": 487, "tested_status": "observed", "tested_unit": "patients", "frequency": 3.29, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["lusc_tcga_pan_can_atlas_2018"], "source_ids": ["lusc_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "BRINP3", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "BRINP3 amplification", "genomic_coordinate": null, "observed": 16, "observed_status": "observed", "observed_unit": "patients", "tested": 511, "tested_status": "observed", "tested_unit": "patients", "frequency": 3.13, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["luad_tcga_pan_can_atlas_2018"], "source_ids": ["luad_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "KRAS", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "KRAS amplification", "genomic_coordinate": null, "observed": 15, "observed_status": "observed", "observed_unit": "patients", "tested": 487, "tested_status": "observed", "tested_unit": "patients", "frequency": 3.08, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["lusc_tcga_pan_can_atlas_2018"], "source_ids": ["lusc_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "NPAP1", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "deep deletion", "event_label": "NPAP1 deep deletion", "genomic_coordinate": null, "observed": 15, "observed_status": "observed", "observed_unit": "patients", "tested": 511, "tested_status": "observed", "tested_unit": "patients", "frequency": 2.94, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["luad_tcga_pan_can_atlas_2018"], "source_ids": ["luad_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "PXDNL", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "PXDNL amplification", "genomic_coordinate": null, "observed": 15, "observed_status": "observed", "observed_unit": "patients", "tested": 511, "tested_status": "observed", "tested_unit": "patients", "frequency": 2.94, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["luad_tcga_pan_can_atlas_2018"], "source_ids": ["luad_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "CACNA1E", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "CACNA1E amplification", "genomic_coordinate": null, "observed": 15, "observed_status": "observed", "observed_unit": "patients", "tested": 511, "tested_status": "observed", "tested_unit": "patients", "frequency": 2.94, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["luad_tcga_pan_can_atlas_2018"], "source_ids": ["luad_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "HERC2", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "deep deletion", "event_label": "HERC2 deep deletion", "genomic_coordinate": null, "observed": 15, "observed_status": "observed", "observed_unit": "patients", "tested": 511, "tested_status": "observed", "tested_unit": "patients", "frequency": 2.94, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["luad_tcga_pan_can_atlas_2018"], "source_ids": ["luad_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "MET", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "MET amplification", "genomic_coordinate": null, "observed": 25, "observed_status": "observed", "observed_unit": "patients", "tested": 860, "tested_status": "observed", "tested_unit": "patients", "frequency": 2.91, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["lung_msk_2017"], "source_ids": ["lung_msk_2017_cna"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "NRXN1", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "NRXN1 amplification", "genomic_coordinate": null, "observed": 14, "observed_status": "observed", "observed_unit": "patients", "tested": 487, "tested_status": "observed", "tested_unit": "patients", "frequency": 2.87, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["lusc_tcga_pan_can_atlas_2018"], "source_ids": ["lusc_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "MXRA5", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "deep deletion", "event_label": "MXRA5 deep deletion", "genomic_coordinate": null, "observed": 14, "observed_status": "observed", "observed_unit": "patients", "tested": 487, "tested_status": "observed", "tested_unit": "patients", "frequency": 2.87, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["lusc_tcga_pan_can_atlas_2018"], "source_ids": ["lusc_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "TSHZ3", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "TSHZ3 amplification", "genomic_coordinate": null, "observed": 13, "observed_status": "observed", "observed_unit": "patients", "tested": 511, "tested_status": "observed", "tested_unit": "patients", "frequency": 2.54, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["luad_tcga_pan_can_atlas_2018"], "source_ids": ["luad_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "ERBB2", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "ERBB2 amplification", "genomic_coordinate": null, "observed": 12, "observed_status": "observed", "observed_unit": "patients", "tested": 487, "tested_status": "observed", "tested_unit": "patients", "frequency": 2.46, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["lusc_tcga_pan_can_atlas_2018"], "source_ids": ["lusc_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "PXDNL", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "PXDNL amplification", "genomic_coordinate": null, "observed": 11, "observed_status": "observed", "observed_unit": "patients", "tested": 487, "tested_status": "observed", "tested_unit": "patients", "frequency": 2.26, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["lusc_tcga_pan_can_atlas_2018"], "source_ids": ["lusc_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "CACNA1E", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "CACNA1E amplification", "genomic_coordinate": null, "observed": 11, "observed_status": "observed", "observed_unit": "patients", "tested": 487, "tested_status": "observed", "tested_unit": "patients", "frequency": 2.26, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["lusc_tcga_pan_can_atlas_2018"], "source_ids": ["lusc_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "MET", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "MET amplification", "genomic_coordinate": null, "observed": 11, "observed_status": "observed", "observed_unit": "patients", "tested": 511, "tested_status": "observed", "tested_unit": "patients", "frequency": 2.15, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["luad_tcga_pan_can_atlas_2018"], "source_ids": ["luad_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "ASXL3", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "ASXL3 amplification", "genomic_coordinate": null, "observed": 10, "observed_status": "observed", "observed_unit": "patients", "tested": 487, "tested_status": "observed", "tested_unit": "patients", "frequency": 2.05, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["lusc_tcga_pan_can_atlas_2018"], "source_ids": ["lusc_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "PKHD1", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "PKHD1 amplification", "genomic_coordinate": null, "observed": 10, "observed_status": "observed", "observed_unit": "patients", "tested": 487, "tested_status": "observed", "tested_unit": "patients", "frequency": 2.05, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["lusc_tcga_pan_can_atlas_2018"], "source_ids": ["lusc_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}], "modality_summary": [{"modality": "SNV / small indel", "available_cohorts": 3, "total_cohorts": 3}, {"modality": "Copy number (discrete)", "available_cohorts": 3, "total_cohorts": 3}, {"modality": "Structural variant (present, not read)", "available_cohorts": 3, "total_cohorts": 3}], "chromosome_summary": [], "cohorts": [{"name": "TCGA PanCancer Atlas lung adenocarcinoma (2018)", "source": "cBioPortal", "accession": "luad_tcga_pan_can_atlas_2018", "patients": {"value": 566, "status": "observed", "unit": "patients"}, "samples": {"value": 566, "status": "observed", "unit": "samples"}, "disease_subtype": "Lung Adenocarcinoma (TCGA, PanCancer Atlas)", "assay_type": "exome or genome", "sequencing_method": "WES (566)", "genome_build": "hg19", "alteration_types_available": ["SNV", "small indel", "amplification", "deep deletion", "structural variant (profile present, not read)"], "genes_assayed": "all coding genes", "primary_or_metastatic": null, "age_group": null, "retrieved_at": "2026-09-17", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "source_record_id": "luad_tcga_pan_can_atlas_2018", "is_demo": false, "assay_coverage": {"patients_with_calls": 566, "patients_in_roster": 566, "frequencies_computed": true, "samples_sequenced": 566, "samples_in_study": 566, "hypermutated_patients": 1, "median_mutations_per_sample": 186.5, "reason": null}}, {"name": "TCGA PanCancer Atlas lung squamous (2018)", "source": "cBioPortal", "accession": "lusc_tcga_pan_can_atlas_2018", "patients": {"value": 484, "status": "observed", "unit": "patients"}, "samples": {"value": 484, "status": "observed", "unit": "samples"}, "disease_subtype": "Lung Squamous Cell Carcinoma (TCGA, PanCancer Atlas)", "assay_type": "exome or genome", "sequencing_method": "WES (484)", "genome_build": "hg19", "alteration_types_available": ["SNV", "small indel", "amplification", "deep deletion", "structural variant (profile present, not read)"], "genes_assayed": "all coding genes", "primary_or_metastatic": null, "age_group": null, "retrieved_at": "2026-09-17", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "source_record_id": "lusc_tcga_pan_can_atlas_2018", "is_demo": false, "assay_coverage": {"patients_with_calls": 484, "patients_in_roster": 484, "frequencies_computed": true, "samples_sequenced": 484, "samples_in_study": 487, "hypermutated_patients": 0, "median_mutations_per_sample": 215.0, "reason": null}}, {"name": "MSK-IMPACT non-small cell (Cancer Discov 2017)", "source": "cBioPortal", "accession": "lung_msk_2017", "patients": {"value": 860, "status": "observed", "unit": "patients"}, "samples": {"value": 915, "status": "observed", "unit": "samples"}, "disease_subtype": "Non-Small Cell Cancer (MSK, Cancer Discov 2017)", "assay_type": "targeted panel", "sequencing_method": "IMPACT410 (623), IMPACT341 (292)", "genome_build": "hg19", "alteration_types_available": ["SNV", "small indel", "amplification", "deep deletion", "structural variant (profile present, not read)"], "genes_assayed": "panel genes only; per-gene denominators", "primary_or_metastatic": null, "age_group": null, "retrieved_at": "2026-09-17", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "source_record_id": "lung_msk_2017", "is_demo": false, "assay_coverage": {"patients_with_calls": 860, "patients_in_roster": 860, "frequencies_computed": true, "samples_sequenced": 915, "samples_in_study": 915, "hypermutated_patients": 0, "median_mutations_per_sample": 6, "reason": null}}], "sources": [{"source_name": "cBioPortal · TCGA PanCancer Atlas lung adenocarcinoma (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=luad_tcga_pan_can_atlas_2018", "source_record_id": "luad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · TCGA PanCancer Atlas lung squamous (2018)", "source_url": "https://www.cbioportal.org/study/summary?id=lusc_tcga_pan_can_atlas_2018", "source_record_id": "lusc_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · MSK-IMPACT non-small cell (Cancer Discov 2017)", "source_url": "https://www.cbioportal.org/study/summary?id=lung_msk_2017", "source_record_id": "lung_msk_2017", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "limitations": ["A cBioPortal public-API snapshot retrieved 2026-09-17; the page does not refresh source data at request time.", "Counts are patients with at least one non-silent call in the study's sequenced sample list; silent, intronic and UTR calls are excluded.", "For targeted-panel cohorts each gene divides by the patients whose panel carried it; a gene absent from the panel is shown as not assayed, not as zero.", "Copy-number rows use discrete calls (2 = high-level amplification, −2 = deep deletion) against the cohort's copy-number sample list, which is a different roster from the sequenced one.", "Cohorts are not pooled. Cross-study patient overlap has not been checked and no disease-wide frequency is reported.", "Structural variants and fusions are not read in this snapshot even where the study carries a profile; germline variants, mutational signatures, TMB and MSI are not reported.", "The gene set is the briefing's curated targets plus the reference cohort's most frequently mutated genes; it is not genome-wide."], "answer_block": ["In TCGA PanCancer Atlas lung adenocarcinoma (2018) (566 sequenced patients, exome or genome), the most frequently altered of the 50 genes shown are TP53 50.71%, KRAS 29.68%, NAV3 21.38%, PCDH15 20.32%, KEAP1 18.02%. Each figure divides by the patients on whom that gene could be called.", "1 of 566 patients are hypermutated (more than 1865 non-silent mutations, ten times the cohort median of 186); every gene's frequency without them is beside the headline.", "Of the briefing's 14 curated targets, 3 are altered in under 2% of this cohort (ERBB2, CD274, DLL3): targets by expression, dependency or drug label, not by mutation. Frequency is not targetability, in either direction.", "3 cohorts are shown and none are pooled; overlap between them has not been checked and there is no disease-wide percentage."], "key_findings": [{"finding": "TP53 is mutated in 287 of 566 patients in TCGA PanCancer Atlas lung adenocarcinoma (2018).", "numerator": 287, "denominator": 566, "frequency": 50.71, "cohorts": 3, "evidence_confidence": "moderate", "source": "luad_tcga_pan_can_atlas_2018", "retrieved_at": "2026-09-17"}, {"finding": "KRAS is mutated in 168 of 566 patients in TCGA PanCancer Atlas lung adenocarcinoma (2018).", "numerator": 168, "denominator": 566, "frequency": 29.68, "cohorts": 3, "evidence_confidence": "moderate", "source": "luad_tcga_pan_can_atlas_2018", "retrieved_at": "2026-09-17"}, {"finding": "NAV3 is mutated in 121 of 566 patients in TCGA PanCancer Atlas lung adenocarcinoma (2018).", "numerator": 121, "denominator": 566, "frequency": 21.38, "cohorts": 2, "evidence_confidence": "moderate", "source": "luad_tcga_pan_can_atlas_2018", "retrieved_at": "2026-09-17"}], "research_gaps": [{"kind": "Structural variants", "text": "Read the structural-variant profiles the studies carry; fusions are the defining event in several of these diseases."}, {"kind": "Context", "text": "Stage, subtype, age and treatment line are not attached to any count; the cohorts differ on all four."}, {"kind": "Interpretation", "text": "Activating versus inactivating, actionable versus not, and evidence level are not inferred here; the briefing's target table carries the drug and trial facts."}], "observations": [], "data_status": "PUBLIC SOURCE SNAPSHOT", "is_demo": false, "reference_cohort": "luad_tcga_pan_can_atlas_2018", "region_events": [], "matrix": [{"label": "EGFR", "kind": "SNV / small indel", "gene": "EGFR", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 12.19, "altered": 69, "tested": 566, "note": null}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 2.48, "altered": 12, "tested": 484, "note": null}, {"cohort": "lung_msk_2017", "status": "observed", "frequency": 28.37, "altered": 244, "tested": 860, "note": null}]}, {"label": "EGFR", "kind": "amplification", "gene": "EGFR", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 5.09, "altered": 26, "tested": 511, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 6.37, "altered": 31, "tested": 487, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "lung_msk_2017", "status": "observed", "frequency": 8.95, "altered": 77, "tested": 860, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "ALK", "kind": "SNV / small indel", "gene": "ALK", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 6.01, "altered": 34, "tested": 566, "note": null}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.72, "altered": 18, "tested": 484, "note": null}, {"cohort": "lung_msk_2017", "status": "observed", "frequency": 4.53, "altered": 39, "tested": 860, "note": null}]}, {"label": "KRAS", "kind": "SNV / small indel", "gene": "KRAS", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 29.68, "altered": 168, "tested": 566, "note": null}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 1.45, "altered": 7, "tested": 484, "note": null}, {"cohort": "lung_msk_2017", "status": "observed", "frequency": 27.44, "altered": 236, "tested": 860, "note": null}]}, {"label": "KRAS", "kind": "amplification", "gene": "KRAS", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 5.68, "altered": 29, "tested": 511, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.08, "altered": 15, "tested": 487, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "lung_msk_2017", "status": "observed", "frequency": 1.74, "altered": 15, "tested": 860, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "ROS1", "kind": "SNV / small indel", "gene": "ROS1", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 4.42, "altered": 25, "tested": 566, "note": null}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 7.64, "altered": 37, "tested": 484, "note": null}, {"cohort": "lung_msk_2017", "status": "observed", "frequency": 1.98, "altered": 17, "tested": 860, "note": null}]}, {"label": "BRAF", "kind": "SNV / small indel", "gene": "BRAF", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 7.24, "altered": 41, "tested": 566, "note": null}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.1, "altered": 15, "tested": 484, "note": null}, {"cohort": "lung_msk_2017", "status": "observed", "frequency": 5.81, "altered": 50, "tested": 860, "note": null}]}, {"label": "MET", "kind": "SNV / small indel", "gene": "MET", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.71, "altered": 21, "tested": 566, "note": null}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 1.65, "altered": 8, "tested": 484, "note": null}, {"cohort": "lung_msk_2017", "status": "observed", "frequency": 4.19, "altered": 36, "tested": 860, "note": null}]}, {"label": "MET", "kind": "amplification", "gene": "MET", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 2.15, "altered": 11, "tested": 511, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 1.44, "altered": 7, "tested": 487, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "lung_msk_2017", "status": "observed", "frequency": 2.91, "altered": 25, "tested": 860, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "RET", "kind": "SNV / small indel", "gene": "RET", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.36, "altered": 19, "tested": 566, "note": null}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.31, "altered": 16, "tested": 484, "note": null}, {"cohort": "lung_msk_2017", "status": "observed", "frequency": 2.67, "altered": 23, "tested": 860, "note": null}]}, {"label": "ERBB2", "kind": "SNV / small indel", "gene": "ERBB2", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 1.59, "altered": 9, "tested": 566, "note": null}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 1.86, "altered": 9, "tested": 484, "note": null}, {"cohort": "lung_msk_2017", "status": "observed", "frequency": 4.19, "altered": 36, "tested": 860, "note": null}]}, {"label": "ERBB2", "kind": "amplification", "gene": "ERBB2", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 1.76, "altered": 9, "tested": 511, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 2.46, "altered": 12, "tested": 487, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "lung_msk_2017", "status": "observed", "frequency": 3.37, "altered": 29, "tested": 860, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "NTRK1", "kind": "SNV / small indel", "gene": "NTRK1", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.0, "altered": 17, "tested": 566, "note": null}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 2.48, "altered": 12, "tested": 484, "note": null}, {"cohort": "lung_msk_2017", "status": "observed", "frequency": 2.21, "altered": 19, "tested": 860, "note": null}]}, {"label": "NTRK1", "kind": "amplification", "gene": "NTRK1", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 7.05, "altered": 36, "tested": 511, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.29, "altered": 16, "tested": 487, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "lung_msk_2017", "status": "observed", "frequency": 0.81, "altered": 7, "tested": 860, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "TP53", "kind": "SNV / small indel", "gene": "TP53", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 50.71, "altered": 287, "tested": 566, "note": null}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 81.4, "altered": 394, "tested": 484, "note": null}, {"cohort": "lung_msk_2017", "status": "observed", "frequency": 53.6, "altered": 461, "tested": 860, "note": null}]}, {"label": "STK11", "kind": "SNV / small indel", "gene": "STK11", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 13.07, "altered": 74, "tested": 566, "note": null}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 1.03, "altered": 5, "tested": 484, "note": null}, {"cohort": "lung_msk_2017", "status": "observed", "frequency": 17.56, "altered": 151, "tested": 860, "note": null}]}, {"label": "KEAP1", "kind": "SNV / small indel", "gene": "KEAP1", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 18.02, "altered": 102, "tested": 566, "note": null}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 10.12, "altered": 49, "tested": 484, "note": null}, {"cohort": "lung_msk_2017", "status": "observed", "frequency": 17.33, "altered": 149, "tested": 860, "note": null}]}, {"label": "CD274", "kind": "SNV / small indel", "gene": "CD274", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 0.71, "altered": 4, "tested": 566, "note": null}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 0.21, "altered": 1, "tested": 484, "note": null}, {"cohort": "lung_msk_2017", "status": "observed", "frequency": 0.12, "altered": 1, "tested": 860, "note": null}]}, {"label": "DLL3", "kind": "SNV / small indel", "gene": "DLL3", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 1.06, "altered": 6, "tested": 566, "note": null}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 1.24, "altered": 6, "tested": 484, "note": null}, {"cohort": "lung_msk_2017", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "DLL3", "kind": "amplification", "gene": "DLL3", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 1.37, "altered": 7, "tested": 511, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 6.98, "altered": 34, "tested": 487, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "lung_msk_2017", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 860, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "NAV3", "kind": "SNV / small indel", "gene": "NAV3", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 21.38, "altered": 121, "tested": 566, "note": null}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 21.28, "altered": 103, "tested": 484, "note": null}, {"cohort": "lung_msk_2017", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "PCDH15", "kind": "SNV / small indel", "gene": "PCDH15", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 20.32, "altered": 115, "tested": 566, "note": null}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 19.21, "altered": 93, "tested": 484, "note": null}, {"cohort": "lung_msk_2017", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "ADAMTS12", "kind": "SNV / small indel", "gene": "ADAMTS12", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 17.49, "altered": 99, "tested": 566, "note": null}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 16.74, "altered": 81, "tested": 484, "note": null}, {"cohort": "lung_msk_2017", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "ADAMTS12", "kind": "amplification", "gene": "ADAMTS12", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 8.02, "altered": 41, "tested": 511, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 9.65, "altered": 47, "tested": 487, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "lung_msk_2017", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 860, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "ADGRG4", "kind": "SNV / small indel", "gene": "ADGRG4", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 17.31, "altered": 98, "tested": 566, "note": null}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 10.74, "altered": 52, "tested": 484, "note": null}, {"cohort": "lung_msk_2017", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "TNR", "kind": "SNV / small indel", "gene": "TNR", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 16.78, "altered": 95, "tested": 566, "note": null}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 15.08, "altered": 73, "tested": 484, "note": null}, {"cohort": "lung_msk_2017", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "TNR", "kind": "amplification", "gene": "TNR", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.33, "altered": 17, "tested": 511, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.9, "altered": 19, "tested": 487, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "lung_msk_2017", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 860, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "SI", "kind": "SNV / small indel", "gene": "SI", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 16.43, "altered": 93, "tested": 566, "note": null}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 17.36, "altered": 84, "tested": 484, "note": null}, {"cohort": "lung_msk_2017", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "SI", "kind": "amplification", "gene": "SI", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 1.96, "altered": 10, "tested": 511, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 29.36, "altered": 143, "tested": 487, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "lung_msk_2017", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 860, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "NRXN1", "kind": "SNV / small indel", "gene": "NRXN1", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 16.25, "altered": 92, "tested": 566, "note": null}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 9.71, "altered": 47, "tested": 484, "note": null}, {"cohort": "lung_msk_2017", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "NRXN1", "kind": "amplification", "gene": "NRXN1", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 0.78, "altered": 4, "tested": 511, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 2.87, "altered": 14, "tested": 487, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "lung_msk_2017", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 860, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "PTPRD", "kind": "SNV / small indel", "gene": "PTPRD", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 16.08, "altered": 91, "tested": 566, "note": null}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 6.4, "altered": 31, "tested": 484, "note": null}, {"cohort": "lung_msk_2017", "status": "observed", "frequency": 10.35, "altered": 89, "tested": 860, "note": null}]}, {"label": "PTPRD", "kind": "deep deletion", "gene": "PTPRD", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 8.22, "altered": 42, "tested": 511, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 6.78, "altered": 33, "tested": 487, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "lung_msk_2017", "status": "observed", "frequency": 0.93, "altered": 8, "tested": 860, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "CDH10", "kind": "SNV / small indel", "gene": "CDH10", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 16.08, "altered": 91, "tested": 566, "note": null}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 19.63, "altered": 95, "tested": 484, "note": null}, {"cohort": "lung_msk_2017", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "CDH10", "kind": "amplification", "gene": "CDH10", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 7.44, "altered": 38, "tested": 511, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 10.27, "altered": 50, "tested": 487, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "lung_msk_2017", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 860, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "NPAP1", "kind": "SNV / small indel", "gene": "NPAP1", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 15.37, "altered": 87, "tested": 566, "note": null}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 8.88, "altered": 43, "tested": 484, "note": null}, {"cohort": "lung_msk_2017", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "NPAP1", "kind": "deep deletion", "gene": "NPAP1", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 2.94, "altered": 15, "tested": 511, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 0.82, "altered": 4, "tested": 487, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "lung_msk_2017", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 860, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "ERICH3", "kind": "SNV / small indel", "gene": "ERICH3", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 15.37, "altered": 87, "tested": 566, "note": null}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 17.36, "altered": 84, "tested": 484, "note": null}, {"cohort": "lung_msk_2017", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "PXDNL", "kind": "SNV / small indel", "gene": "PXDNL", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 15.19, "altered": 86, "tested": 566, "note": null}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 10.54, "altered": 51, "tested": 484, "note": null}, {"cohort": "lung_msk_2017", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "PXDNL", "kind": "amplification", "gene": "PXDNL", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 2.94, "altered": 15, "tested": 511, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 2.26, "altered": 11, "tested": 487, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "lung_msk_2017", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 860, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "PCDH11X", "kind": "SNV / small indel", "gene": "PCDH11X", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 15.19, "altered": 86, "tested": 566, "note": null}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 15.08, "altered": 73, "tested": 484, "note": null}, {"cohort": "lung_msk_2017", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "FAM135B", "kind": "SNV / small indel", "gene": "FAM135B", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 15.19, "altered": 86, "tested": 566, "note": null}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 24.38, "altered": 118, "tested": 484, "note": null}, {"cohort": "lung_msk_2017", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "FAM135B", "kind": "amplification", "gene": "FAM135B", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 5.28, "altered": 27, "tested": 511, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 4.31, "altered": 21, "tested": 487, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "lung_msk_2017", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 860, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "CACNA1E", "kind": "SNV / small indel", "gene": "CACNA1E", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 15.19, "altered": 86, "tested": 566, "note": null}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 9.92, "altered": 48, "tested": 484, "note": null}, {"cohort": "lung_msk_2017", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "CACNA1E", "kind": "amplification", "gene": "CACNA1E", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 2.94, "altered": 15, "tested": 511, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 2.26, "altered": 11, "tested": 487, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "lung_msk_2017", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 860, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "RELN", "kind": "SNV / small indel", "gene": "RELN", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 14.84, "altered": 84, "tested": 566, "note": null}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 15.91, "altered": 77, "tested": 484, "note": null}, {"cohort": "lung_msk_2017", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "RELN", "kind": "amplification", "gene": "RELN", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 1.76, "altered": 9, "tested": 511, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.29, "altered": 16, "tested": 487, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "lung_msk_2017", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 860, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "NALCN", "kind": "SNV / small indel", "gene": "NALCN", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 14.84, "altered": 84, "tested": 566, "note": null}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 8.47, "altered": 41, "tested": 484, "note": null}, {"cohort": "lung_msk_2017", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "LRRC7", "kind": "SNV / small indel", "gene": "LRRC7", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 14.66, "altered": 83, "tested": 566, "note": null}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 12.81, "altered": 62, "tested": 484, "note": null}, {"cohort": "lung_msk_2017", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "VCAN", "kind": "SNV / small indel", "gene": "VCAN", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 14.31, "altered": 81, "tested": 566, "note": null}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 8.47, "altered": 41, "tested": 484, "note": null}, {"cohort": "lung_msk_2017", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "MXRA5", "kind": "SNV / small indel", "gene": "MXRA5", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 14.31, "altered": 81, "tested": 566, "note": null}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 7.23, "altered": 35, "tested": 484, "note": null}, {"cohort": "lung_msk_2017", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "MXRA5", "kind": "deep deletion", "gene": "MXRA5", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 1.37, "altered": 7, "tested": 511, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 2.87, "altered": 14, "tested": 487, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "lung_msk_2017", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 860, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "ASTN1", "kind": "SNV / small indel", "gene": "ASTN1", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 14.13, "altered": 80, "tested": 566, "note": null}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 9.5, "altered": 46, "tested": 484, "note": null}, {"cohort": "lung_msk_2017", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "ASTN1", "kind": "amplification", "gene": "ASTN1", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.52, "altered": 18, "tested": 511, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.49, "altered": 17, "tested": 487, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "lung_msk_2017", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 860, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "PRDM9", "kind": "SNV / small indel", "gene": "PRDM9", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 13.96, "altered": 79, "tested": 566, "note": null}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 14.26, "altered": 69, "tested": 484, "note": null}, {"cohort": "lung_msk_2017", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "PRDM9", "kind": "amplification", "gene": "PRDM9", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 7.05, "altered": 36, "tested": 511, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 10.06, "altered": 49, "tested": 487, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "lung_msk_2017", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 860, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "KMT2C", "kind": "SNV / small indel", "gene": "KMT2C", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 13.43, "altered": 76, "tested": 566, "note": null}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 14.67, "altered": 71, "tested": 484, "note": null}, {"cohort": "lung_msk_2017", "status": "observed", "frequency": 6.16, "altered": 53, "tested": 860, "note": null}]}, {"label": "ASXL3", "kind": "SNV / small indel", "gene": "ASXL3", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 13.25, "altered": 75, "tested": 566, "note": null}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 7.64, "altered": 37, "tested": 484, "note": null}, {"cohort": "lung_msk_2017", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "ASXL3", "kind": "amplification", "gene": "ASXL3", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 1.17, "altered": 6, "tested": 511, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 2.05, "altered": 10, "tested": 487, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "lung_msk_2017", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 860, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "ASPM", "kind": "SNV / small indel", "gene": "ASPM", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 13.25, "altered": 75, "tested": 566, "note": null}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 8.68, "altered": 42, "tested": 484, "note": null}, {"cohort": "lung_msk_2017", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "ASPM", "kind": "amplification", "gene": "ASPM", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.33, "altered": 17, "tested": 511, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 1.44, "altered": 7, "tested": 487, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "lung_msk_2017", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 860, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "PKHD1", "kind": "SNV / small indel", "gene": "PKHD1", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 13.07, "altered": 74, "tested": 566, "note": null}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 17.77, "altered": 86, "tested": 484, "note": null}, {"cohort": "lung_msk_2017", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "PKHD1", "kind": "amplification", "gene": "PKHD1", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 0.98, "altered": 5, "tested": 511, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 2.05, "altered": 10, "tested": 487, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "lung_msk_2017", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 860, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "HRNR", "kind": "SNV / small indel", "gene": "HRNR", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 13.07, "altered": 74, "tested": 566, "note": null}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 6.61, "altered": 32, "tested": 484, "note": null}, {"cohort": "lung_msk_2017", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "HRNR", "kind": "amplification", "gene": "HRNR", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 9.59, "altered": 49, "tested": 511, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 4.31, "altered": 21, "tested": 487, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "lung_msk_2017", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 860, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "TSHZ3", "kind": "SNV / small indel", "gene": "TSHZ3", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 12.9, "altered": 73, "tested": 566, "note": null}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 5.37, "altered": 26, "tested": 484, "note": null}, {"cohort": "lung_msk_2017", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "TSHZ3", "kind": "amplification", "gene": "TSHZ3", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 2.54, "altered": 13, "tested": 511, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 4.31, "altered": 21, "tested": 487, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "lung_msk_2017", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 860, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "TNN", "kind": "SNV / small indel", "gene": "TNN", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 12.9, "altered": 73, "tested": 566, "note": null}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 12.19, "altered": 59, "tested": 484, "note": null}, {"cohort": "lung_msk_2017", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "TNN", "kind": "amplification", "gene": "TNN", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.52, "altered": 18, "tested": 511, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.7, "altered": 18, "tested": 487, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "lung_msk_2017", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 860, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "PEG3", "kind": "SNV / small indel", "gene": "PEG3", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 12.9, "altered": 73, "tested": 566, "note": null}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 12.81, "altered": 62, "tested": 484, "note": null}, {"cohort": "lung_msk_2017", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "RIMS2", "kind": "SNV / small indel", "gene": "RIMS2", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 12.72, "altered": 72, "tested": 566, "note": null}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 7.85, "altered": 38, "tested": 484, "note": null}, {"cohort": "lung_msk_2017", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "RIMS2", "kind": "amplification", "gene": "RIMS2", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 5.09, "altered": 26, "tested": 511, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.49, "altered": 17, "tested": 487, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "lung_msk_2017", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 860, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "LAMA2", "kind": "SNV / small indel", "gene": "LAMA2", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 12.72, "altered": 72, "tested": 566, "note": null}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 13.64, "altered": 66, "tested": 484, "note": null}, {"cohort": "lung_msk_2017", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "BRINP3", "kind": "SNV / small indel", "gene": "BRINP3", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 12.72, "altered": 72, "tested": 566, "note": null}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 13.64, "altered": 66, "tested": 484, "note": null}, {"cohort": "lung_msk_2017", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "BRINP3", "kind": "amplification", "gene": "BRINP3", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.13, "altered": 16, "tested": 511, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 1.64, "altered": 8, "tested": 487, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "lung_msk_2017", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 860, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "HERC2", "kind": "SNV / small indel", "gene": "HERC2", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 12.54, "altered": 71, "tested": 566, "note": null}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 10.54, "altered": 51, "tested": 484, "note": null}, {"cohort": "lung_msk_2017", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "HERC2", "kind": "deep deletion", "gene": "HERC2", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 2.94, "altered": 15, "tested": 511, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 0.82, "altered": 4, "tested": 487, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "lung_msk_2017", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 860, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "MYH1", "kind": "SNV / small indel", "gene": "MYH1", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 12.37, "altered": 70, "tested": 566, "note": null}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 12.4, "altered": 60, "tested": 484, "note": null}, {"cohort": "lung_msk_2017", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "EPHA5", "kind": "SNV / small indel", "gene": "EPHA5", "cells": [{"cohort": "luad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 12.37, "altered": 70, "tested": 566, "note": null}, {"cohort": "lusc_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 9.09, "altered": 44, "tested": 484, "note": null}, {"cohort": "lung_msk_2017", "status": "observed", "frequency": 5.81, "altered": 50, "tested": 860, "note": null}]}]}