{"disease": {"name": "Mantle cell lymphoma", "mondo_id": null, "ncit_id": null, "umls_id": null, "oncotree_code": "mcl"}, "updated_at": "2026-09-17", "genome_builds": ["hg19"], "cohort_count": 1, "cohort_count_status": "observed", "cohort_count_unit": "cohorts", "evaluable_patients": null, "evaluable_patients_status": "unknown", "evaluable_patients_unit": "patients", "alteration_types": ["SNV", "small indel", "amplification", "deep deletion"], "genes": [{"gene": "CCND1", "alteration_types": ["SNV / small indel"], "altered": 10, "tested": 29, "frequency": 34.48, "cohort_count": 1, "frequency_range": {"min": 34.48, "max": 34.48}, "major_variants": ["C47S (n=2)", "Y44D (n=2)", "Y44C (n=1)", "Y44* (n=1)", "Y44H (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · IDIBIPS mantle cell lymphoma (PNAS 2013)", "source_url": "https://www.cbioportal.org/study/summary?id=mcl_idibips_2013", "source_record_id": "mcl_idibips_2013", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: IDIBIPS mantle cell lymphoma (PNAS 2013), 10/29 patients (34.48%).", "Observed in 1 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "mcl_idibips_2013", "cohort_name": "IDIBIPS mantle cell lymphoma (PNAS 2013)", "altered": 10, "tested": 29, "frequency": 34.48, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "29/29", "coverage_note": null, "source_id": "mcl_idibips_2013", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 100.0, "width": 1.0, "reference": 100.0, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 10, "tested": 29, "frequency": 34.48, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "BTK", "alteration_types": [], "altered": 0, "tested": 29, "frequency": 0.0, "cohort_count": 0, "frequency_range": {"min": 0.0, "max": 0.0}, "major_variants": [], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · IDIBIPS mantle cell lymphoma (PNAS 2013)", "source_url": "https://www.cbioportal.org/study/summary?id=mcl_idibips_2013", "source_record_id": "mcl_idibips_2013", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: IDIBIPS mantle cell lymphoma (PNAS 2013), 0/29 patients (0.0%).", "Observed in 0 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "mcl_idibips_2013", "cohort_name": "IDIBIPS mantle cell lymphoma (PNAS 2013)", "altered": 0, "tested": 29, "frequency": 0.0, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "29/29", "coverage_note": null, "source_id": "mcl_idibips_2013", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 0.0, "width": 1.0, "reference": 0.0, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 0, "tested": 29, "frequency": 0.0, "is_mutation": true}, "altered_status": "not_observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "not_observed", "frequency_unit": "percent", "cohort_count_status": "not_observed", "cohort_count_unit": "cohorts"}, {"gene": "SOX11", "alteration_types": [], "altered": 0, "tested": 29, "frequency": 0.0, "cohort_count": 0, "frequency_range": {"min": 0.0, "max": 0.0}, "major_variants": [], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · IDIBIPS mantle cell lymphoma (PNAS 2013)", "source_url": "https://www.cbioportal.org/study/summary?id=mcl_idibips_2013", "source_record_id": "mcl_idibips_2013", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: IDIBIPS mantle cell lymphoma (PNAS 2013), 0/29 patients (0.0%).", "Observed in 0 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "mcl_idibips_2013", "cohort_name": "IDIBIPS mantle cell lymphoma (PNAS 2013)", "altered": 0, "tested": 29, "frequency": 0.0, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "29/29", "coverage_note": null, "source_id": "mcl_idibips_2013", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 0.0, "width": 1.0, "reference": 0.0, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 0, "tested": 29, "frequency": 0.0, "is_mutation": true}, "altered_status": "not_observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "not_observed", "frequency_unit": "percent", "cohort_count_status": "not_observed", "cohort_count_unit": "cohorts"}, {"gene": "TP53", "alteration_types": ["SNV / small indel"], "altered": 5, "tested": 29, "frequency": 17.24, "cohort_count": 1, "frequency_range": {"min": 17.24, "max": 17.24}, "major_variants": ["Y126_T140del (n=1)", "P278H (n=1)", "F54Sfs*69 (n=1)", "D184H (n=1)", "R273S (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · IDIBIPS mantle cell lymphoma (PNAS 2013)", "source_url": "https://www.cbioportal.org/study/summary?id=mcl_idibips_2013", "source_record_id": "mcl_idibips_2013", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: IDIBIPS mantle cell lymphoma (PNAS 2013), 5/29 patients (17.24%).", "Observed in 1 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "mcl_idibips_2013", "cohort_name": "IDIBIPS mantle cell lymphoma (PNAS 2013)", "altered": 5, "tested": 29, "frequency": 17.24, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "29/29", "coverage_note": null, "source_id": "mcl_idibips_2013", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 57.47, "width": 1.0, "reference": 57.47, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 5, "tested": 29, "frequency": 17.24, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "ATM", "alteration_types": ["SNV / small indel"], "altered": 12, "tested": 29, "frequency": 41.38, "cohort_count": 1, "frequency_range": {"min": 41.38, "max": 41.38}, "major_variants": ["D2448A (n=1)", "Q2730R (n=1)", "I323V (n=1)", "R3008C (n=1)", "R2526S (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · IDIBIPS mantle cell lymphoma (PNAS 2013)", "source_url": "https://www.cbioportal.org/study/summary?id=mcl_idibips_2013", "source_record_id": "mcl_idibips_2013", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: IDIBIPS mantle cell lymphoma (PNAS 2013), 12/29 patients (41.38%).", "Observed in 1 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "mcl_idibips_2013", "cohort_name": "IDIBIPS mantle cell lymphoma (PNAS 2013)", "altered": 12, "tested": 29, "frequency": 41.38, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "29/29", "coverage_note": null, "source_id": "mcl_idibips_2013", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 100.0, "width": 1.0, "reference": 100.0, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 12, "tested": 29, "frequency": 41.38, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "CDKN2A", "alteration_types": [], "altered": 0, "tested": 29, "frequency": 0.0, "cohort_count": 0, "frequency_range": {"min": 0.0, "max": 0.0}, "major_variants": [], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · IDIBIPS mantle cell lymphoma (PNAS 2013)", "source_url": "https://www.cbioportal.org/study/summary?id=mcl_idibips_2013", "source_record_id": "mcl_idibips_2013", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: IDIBIPS mantle cell lymphoma (PNAS 2013), 0/29 patients (0.0%).", "Observed in 0 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "mcl_idibips_2013", "cohort_name": "IDIBIPS mantle cell lymphoma (PNAS 2013)", "altered": 0, "tested": 29, "frequency": 0.0, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "29/29", "coverage_note": null, "source_id": "mcl_idibips_2013", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 0.0, "width": 1.0, "reference": 0.0, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 0, "tested": 29, "frequency": 0.0, "is_mutation": true}, "altered_status": "not_observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "not_observed", "frequency_unit": "percent", "cohort_count_status": "not_observed", "cohort_count_unit": "cohorts"}, {"gene": "KMT2D", "alteration_types": ["SNV / small indel"], "altered": 4, "tested": 29, "frequency": 13.79, "cohort_count": 1, "frequency_range": {"min": 13.79, "max": 13.79}, "major_variants": ["A5272P (n=1)", "R2771Q (n=1)", "D1724Gfs*8 (n=1)", "Q3604K (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · IDIBIPS mantle cell lymphoma (PNAS 2013)", "source_url": "https://www.cbioportal.org/study/summary?id=mcl_idibips_2013", "source_record_id": "mcl_idibips_2013", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: IDIBIPS mantle cell lymphoma (PNAS 2013), 4/29 patients (13.79%).", "Observed in 1 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "mcl_idibips_2013", "cohort_name": "IDIBIPS mantle cell lymphoma (PNAS 2013)", "altered": 4, "tested": 29, "frequency": 13.79, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "29/29", "coverage_note": null, "source_id": "mcl_idibips_2013", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 45.97, "width": 1.0, "reference": 45.97, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 4, "tested": 29, "frequency": 13.79, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "NSD2", "alteration_types": ["SNV / small indel"], "altered": 4, "tested": 29, "frequency": 13.79, "cohort_count": 1, "frequency_range": {"min": 13.79, "max": 13.79}, "major_variants": ["T1150A (n=2)", "E1099K (n=2)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · IDIBIPS mantle cell lymphoma (PNAS 2013)", "source_url": "https://www.cbioportal.org/study/summary?id=mcl_idibips_2013", "source_record_id": "mcl_idibips_2013", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: IDIBIPS mantle cell lymphoma (PNAS 2013), 4/29 patients (13.79%).", "Observed in 1 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "mcl_idibips_2013", "cohort_name": "IDIBIPS mantle cell lymphoma (PNAS 2013)", "altered": 4, "tested": 29, "frequency": 13.79, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "29/29", "coverage_note": null, "source_id": "mcl_idibips_2013", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 45.97, "width": 1.0, "reference": 45.97, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 4, "tested": 29, "frequency": 13.79, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "BCL2", "alteration_types": [], "altered": 0, "tested": 29, "frequency": 0.0, "cohort_count": 0, "frequency_range": {"min": 0.0, "max": 0.0}, "major_variants": [], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; 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not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · IDIBIPS mantle cell lymphoma (PNAS 2013)", "source_url": "https://www.cbioportal.org/study/summary?id=mcl_idibips_2013", "source_record_id": "mcl_idibips_2013", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: IDIBIPS mantle cell lymphoma (PNAS 2013), 2/29 patients (6.9%).", "Observed in 1 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "mcl_idibips_2013", "cohort_name": "IDIBIPS mantle cell lymphoma (PNAS 2013)", "altered": 2, "tested": 29, "frequency": 6.9, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "29/29", "coverage_note": null, "source_id": "mcl_idibips_2013", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 23.0, "width": 1.0, "reference": 23.0, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 2, "tested": 29, "frequency": 6.9, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "DLGAP2", "alteration_types": ["SNV / small indel"], "altered": 2, "tested": 29, "frequency": 6.9, "cohort_count": 1, "frequency_range": {"min": 6.9, "max": 6.9}, "major_variants": ["T231M (n=1)", "R633H (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · IDIBIPS mantle cell lymphoma (PNAS 2013)", "source_url": "https://www.cbioportal.org/study/summary?id=mcl_idibips_2013", "source_record_id": "mcl_idibips_2013", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: IDIBIPS mantle cell lymphoma (PNAS 2013), 2/29 patients (6.9%).", "Observed in 1 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "mcl_idibips_2013", "cohort_name": "IDIBIPS mantle cell lymphoma (PNAS 2013)", "altered": 2, "tested": 29, "frequency": 6.9, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "29/29", "coverage_note": null, "source_id": "mcl_idibips_2013", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 23.0, "width": 1.0, "reference": 23.0, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 2, "tested": 29, "frequency": 6.9, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "DCP1B", "alteration_types": ["SNV / small indel"], "altered": 2, "tested": 29, "frequency": 6.9, "cohort_count": 1, "frequency_range": {"min": 6.9, "max": 6.9}, "major_variants": ["Q241E (n=1)", "Q255_Q256insR (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · IDIBIPS mantle cell lymphoma (PNAS 2013)", "source_url": "https://www.cbioportal.org/study/summary?id=mcl_idibips_2013", "source_record_id": "mcl_idibips_2013", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: IDIBIPS mantle cell lymphoma (PNAS 2013), 2/29 patients (6.9%).", "Observed in 1 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "mcl_idibips_2013", "cohort_name": "IDIBIPS mantle cell lymphoma (PNAS 2013)", "altered": 2, "tested": 29, "frequency": 6.9, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "29/29", "coverage_note": null, "source_id": "mcl_idibips_2013", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 23.0, "width": 1.0, "reference": 23.0, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 2, "tested": 29, "frequency": 6.9, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "CRYBG3", "alteration_types": ["SNV / small indel"], "altered": 2, "tested": 29, "frequency": 6.9, "cohort_count": 1, "frequency_range": {"min": 6.9, "max": 6.9}, "major_variants": ["R185C (n=1)", "R705G (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · IDIBIPS mantle cell lymphoma (PNAS 2013)", "source_url": "https://www.cbioportal.org/study/summary?id=mcl_idibips_2013", "source_record_id": "mcl_idibips_2013", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: IDIBIPS mantle cell lymphoma (PNAS 2013), 2/29 patients (6.9%).", "Observed in 1 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "mcl_idibips_2013", "cohort_name": "IDIBIPS mantle cell lymphoma (PNAS 2013)", "altered": 2, "tested": 29, "frequency": 6.9, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "29/29", "coverage_note": null, "source_id": "mcl_idibips_2013", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 23.0, "width": 1.0, "reference": 23.0, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 2, "tested": 29, "frequency": 6.9, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "CHMP4C", "alteration_types": ["SNV / small indel"], "altered": 2, "tested": 29, "frequency": 6.9, "cohort_count": 1, "frequency_range": {"min": 6.9, "max": 6.9}, "major_variants": ["R107S (n=1)", "A52D (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · IDIBIPS mantle cell lymphoma (PNAS 2013)", "source_url": "https://www.cbioportal.org/study/summary?id=mcl_idibips_2013", "source_record_id": "mcl_idibips_2013", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: IDIBIPS mantle cell lymphoma (PNAS 2013), 2/29 patients (6.9%).", "Observed in 1 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "mcl_idibips_2013", "cohort_name": "IDIBIPS mantle cell lymphoma (PNAS 2013)", "altered": 2, "tested": 29, "frequency": 6.9, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "29/29", "coverage_note": null, "source_id": "mcl_idibips_2013", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 23.0, "width": 1.0, "reference": 23.0, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 2, "tested": 29, "frequency": 6.9, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "BIRC3", "alteration_types": ["SNV / small indel"], "altered": 2, "tested": 29, "frequency": 6.9, "cohort_count": 1, "frequency_range": {"min": 6.9, "max": 6.9}, "major_variants": ["Q552* (n=1)", "C581Y (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · IDIBIPS mantle cell lymphoma (PNAS 2013)", "source_url": "https://www.cbioportal.org/study/summary?id=mcl_idibips_2013", "source_record_id": "mcl_idibips_2013", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: IDIBIPS mantle cell lymphoma (PNAS 2013), 2/29 patients (6.9%).", "Observed in 1 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "mcl_idibips_2013", "cohort_name": "IDIBIPS mantle cell lymphoma (PNAS 2013)", "altered": 2, "tested": 29, "frequency": 6.9, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "29/29", "coverage_note": null, "source_id": "mcl_idibips_2013", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 23.0, "width": 1.0, "reference": 23.0, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 2, "tested": 29, "frequency": 6.9, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "ABCC9", "alteration_types": ["SNV / small indel"], "altered": 2, "tested": 29, "frequency": 6.9, "cohort_count": 1, "frequency_range": {"min": 6.9, "max": 6.9}, "major_variants": ["R97W (n=1)", "K778Rfs*34 (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · IDIBIPS mantle cell lymphoma (PNAS 2013)", "source_url": "https://www.cbioportal.org/study/summary?id=mcl_idibips_2013", "source_record_id": "mcl_idibips_2013", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: IDIBIPS mantle cell lymphoma (PNAS 2013), 2/29 patients (6.9%).", "Observed in 1 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "mcl_idibips_2013", "cohort_name": "IDIBIPS mantle cell lymphoma (PNAS 2013)", "altered": 2, "tested": 29, "frequency": 6.9, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "29/29", "coverage_note": null, "source_id": "mcl_idibips_2013", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 23.0, "width": 1.0, "reference": 23.0, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 2, "tested": 29, "frequency": 6.9, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}], "variants": [], "genomic_events": [], "modality_summary": [{"modality": "SNV / small indel", "available_cohorts": 1, "total_cohorts": 1}, {"modality": "Copy number (discrete)", "available_cohorts": 0, "total_cohorts": 1}, {"modality": "Structural variant (present, not read)", "available_cohorts": 0, "total_cohorts": 1}], "chromosome_summary": [], "cohorts": [{"name": "IDIBIPS mantle cell lymphoma (PNAS 2013)", "source": "cBioPortal", "accession": "mcl_idibips_2013", "patients": {"value": 29, "status": "observed", "unit": "patients"}, "samples": {"value": 29, "status": "observed", "unit": "samples"}, "disease_subtype": "Mantle Cell Lymphoma (IDIBIPS, PNAS 2013)", "assay_type": "exome or genome", "sequencing_method": "WES (29)", "genome_build": "hg19", "alteration_types_available": ["SNV", "small indel"], "genes_assayed": "all coding genes", "primary_or_metastatic": null, "age_group": null, "retrieved_at": "2026-09-17", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "source_record_id": "mcl_idibips_2013", "is_demo": false, "assay_coverage": {"patients_with_calls": 29, "patients_in_roster": 29, "frequencies_computed": true, "samples_sequenced": 29, "samples_in_study": 29, "hypermutated_patients": 0, "median_mutations_per_sample": 17, "reason": null}}], "sources": [{"source_name": "cBioPortal · IDIBIPS mantle cell lymphoma (PNAS 2013)", "source_url": "https://www.cbioportal.org/study/summary?id=mcl_idibips_2013", "source_record_id": "mcl_idibips_2013", "source_version": null, "retrieved_at": "2026-09-17", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "limitations": ["A cBioPortal public-API snapshot retrieved 2026-09-17; the page does not refresh source data at request time.", "Counts are patients with at least one non-silent call in the study's sequenced sample list; silent, intronic and UTR calls are excluded.", "For targeted-panel cohorts each gene divides by the patients whose panel carried it; a gene absent from the panel is shown as not assayed, not as zero.", "Copy-number rows use discrete calls (2 = high-level amplification, −2 = deep deletion) against the cohort's copy-number sample list, which is a different roster from the sequenced one.", "Cohorts are not pooled. Cross-study patient overlap has not been checked and no disease-wide frequency is reported.", "Structural variants and fusions are not read in this snapshot even where the study carries a profile; germline variants, mutational signatures, TMB and MSI are not reported.", "The gene set is the briefing's curated targets plus the reference cohort's most frequently mutated genes; it is not genome-wide."], "answer_block": ["In IDIBIPS mantle cell lymphoma (PNAS 2013) (29 sequenced patients, exome or genome), the most frequently altered of the 33 genes shown are ATM 41.38%, CCND1 34.48%, TP53 17.24%, KMT2D 13.79%, NSD2 13.79%. Each figure divides by the patients on whom that gene could be called.", "Of the briefing's 12 curated targets, 7 are altered in under 2% of this cohort (BTK, SOX11, CDKN2A, BCL2, CD19, MS4A1, NOTCH1): targets by expression, dependency or drug label, not by mutation. Frequency is not targetability, in either direction.", "1 cohorts are shown and none are pooled; overlap between them has not been checked and there is no disease-wide percentage."], "key_findings": [{"finding": "ATM is mutated in 12 of 29 patients in IDIBIPS mantle cell lymphoma (PNAS 2013).", "numerator": 12, "denominator": 29, "frequency": 41.38, "cohorts": 1, "evidence_confidence": "moderate", "source": "mcl_idibips_2013", "retrieved_at": "2026-09-17"}, {"finding": "CCND1 is mutated in 10 of 29 patients in IDIBIPS mantle cell lymphoma (PNAS 2013).", "numerator": 10, "denominator": 29, "frequency": 34.48, "cohorts": 1, "evidence_confidence": "moderate", "source": "mcl_idibips_2013", "retrieved_at": "2026-09-17"}, {"finding": "TP53 is mutated in 5 of 29 patients in IDIBIPS mantle cell lymphoma (PNAS 2013).", "numerator": 5, "denominator": 29, "frequency": 17.24, "cohorts": 1, "evidence_confidence": "moderate", "source": "mcl_idibips_2013", "retrieved_at": "2026-09-17"}], "research_gaps": [{"kind": "Structural variants", "text": "Read the structural-variant profiles the studies carry; fusions are the defining event in several of these diseases."}, {"kind": "Context", "text": "Stage, subtype, age and treatment line are not attached to any count; the cohorts differ on all four."}, {"kind": "Interpretation", "text": "Activating versus inactivating, actionable versus not, and evidence level are not inferred here; the briefing's target table carries the drug and trial facts."}], "observations": [], "data_status": "PUBLIC SOURCE SNAPSHOT", "is_demo": false, "reference_cohort": "mcl_idibips_2013", "region_events": [], "matrix": [{"label": "CCND1", "kind": "SNV / small indel", "gene": "CCND1", "cells": [{"cohort": "mcl_idibips_2013", "status": "observed", "frequency": 34.48, "altered": 10, "tested": 29, "note": null}]}, {"label": "BTK", "kind": "SNV / small indel", "gene": "BTK", "cells": [{"cohort": "mcl_idibips_2013", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 29, "note": null}]}, {"label": "SOX11", "kind": "SNV / small indel", "gene": "SOX11", "cells": [{"cohort": "mcl_idibips_2013", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 29, "note": null}]}, {"label": "TP53", "kind": "SNV / small indel", "gene": "TP53", "cells": [{"cohort": "mcl_idibips_2013", "status": "observed", "frequency": 17.24, "altered": 5, "tested": 29, "note": null}]}, {"label": "ATM", "kind": "SNV / small indel", "gene": "ATM", "cells": [{"cohort": "mcl_idibips_2013", "status": "observed", "frequency": 41.38, "altered": 12, "tested": 29, "note": null}]}, {"label": "CDKN2A", "kind": "SNV / small indel", "gene": "CDKN2A", "cells": [{"cohort": "mcl_idibips_2013", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 29, "note": null}]}, {"label": "KMT2D", "kind": "SNV / small indel", "gene": "KMT2D", "cells": [{"cohort": "mcl_idibips_2013", "status": "observed", "frequency": 13.79, "altered": 4, "tested": 29, "note": null}]}, {"label": "NSD2", "kind": "SNV / small indel", "gene": "NSD2", "cells": [{"cohort": "mcl_idibips_2013", "status": "observed", "frequency": 13.79, "altered": 4, "tested": 29, "note": null}]}, {"label": "BCL2", "kind": "SNV / small indel", "gene": "BCL2", "cells": [{"cohort": "mcl_idibips_2013", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 29, "note": null}]}, {"label": "CD19", "kind": "SNV / small indel", "gene": "CD19", "cells": [{"cohort": "mcl_idibips_2013", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 29, "note": null}]}, {"label": "MS4A1", "kind": "SNV / small indel", "gene": "MS4A1", "cells": [{"cohort": "mcl_idibips_2013", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 29, "note": null}]}, {"label": "NOTCH1", "kind": "SNV / small indel", "gene": "NOTCH1", "cells": [{"cohort": "mcl_idibips_2013", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 29, "note": null}]}, {"label": "UNC80", "kind": "SNV / small indel", "gene": "UNC80", "cells": [{"cohort": "mcl_idibips_2013", "status": "observed", "frequency": 6.9, "altered": 2, "tested": 29, "note": null}]}, {"label": "UBR5", "kind": "SNV / small indel", "gene": "UBR5", "cells": [{"cohort": "mcl_idibips_2013", "status": "observed", "frequency": 6.9, "altered": 2, "tested": 29, "note": null}]}, {"label": "TRPM6", "kind": "SNV / small indel", "gene": "TRPM6", "cells": [{"cohort": "mcl_idibips_2013", "status": "observed", "frequency": 6.9, "altered": 2, "tested": 29, "note": null}]}, {"label": "TNRC6B", "kind": "SNV / small indel", "gene": "TNRC6B", "cells": [{"cohort": "mcl_idibips_2013", "status": "observed", "frequency": 6.9, "altered": 2, "tested": 29, "note": null}]}, {"label": "TLR2", "kind": "SNV / small indel", "gene": "TLR2", "cells": [{"cohort": "mcl_idibips_2013", "status": "observed", "frequency": 6.9, "altered": 2, "tested": 29, "note": null}]}, {"label": "TAS2R41", "kind": "SNV / small indel", "gene": "TAS2R41", "cells": [{"cohort": "mcl_idibips_2013", "status": "observed", "frequency": 6.9, "altered": 2, "tested": 29, "note": null}]}, {"label": "SP140", "kind": "SNV / small indel", "gene": "SP140", "cells": [{"cohort": "mcl_idibips_2013", "status": "observed", "frequency": 6.9, "altered": 2, "tested": 29, "note": null}]}, {"label": "SLC17A6", "kind": "SNV / small indel", "gene": "SLC17A6", "cells": [{"cohort": "mcl_idibips_2013", "status": "observed", "frequency": 6.9, "altered": 2, "tested": 29, "note": null}]}, {"label": "RGS4", "kind": "SNV / small indel", "gene": "RGS4", "cells": [{"cohort": "mcl_idibips_2013", "status": "observed", "frequency": 6.9, "altered": 2, "tested": 29, "note": null}]}, {"label": "PCSK2", "kind": "SNV / small indel", "gene": "PCSK2", "cells": [{"cohort": "mcl_idibips_2013", "status": "observed", "frequency": 6.9, "altered": 2, "tested": 29, "note": null}]}, {"label": "MEF2B", "kind": "SNV / small indel", "gene": "MEF2B", "cells": [{"cohort": "mcl_idibips_2013", "status": "observed", "frequency": 6.9, "altered": 2, "tested": 29, "note": null}]}, {"label": "LUZP4", "kind": "SNV / small indel", "gene": "LUZP4", "cells": [{"cohort": "mcl_idibips_2013", "status": "observed", "frequency": 6.9, "altered": 2, "tested": 29, "note": null}]}, {"label": "KIAA1671", "kind": "SNV / small indel", "gene": "KIAA1671", "cells": [{"cohort": "mcl_idibips_2013", "status": "observed", "frequency": 6.9, "altered": 2, "tested": 29, "note": null}]}, {"label": "FLNC", "kind": "SNV / small indel", "gene": "FLNC", "cells": [{"cohort": "mcl_idibips_2013", "status": "observed", "frequency": 6.9, "altered": 2, "tested": 29, "note": null}]}, {"label": "DNAJC6", "kind": "SNV / small indel", "gene": "DNAJC6", "cells": [{"cohort": "mcl_idibips_2013", "status": "observed", "frequency": 6.9, "altered": 2, "tested": 29, "note": null}]}, {"label": "DLGAP2", "kind": "SNV / small indel", "gene": "DLGAP2", "cells": [{"cohort": "mcl_idibips_2013", "status": "observed", "frequency": 6.9, "altered": 2, "tested": 29, "note": null}]}, {"label": "DCP1B", "kind": "SNV / small indel", "gene": "DCP1B", "cells": [{"cohort": "mcl_idibips_2013", "status": "observed", "frequency": 6.9, "altered": 2, "tested": 29, "note": null}]}, {"label": "CRYBG3", "kind": "SNV / small indel", "gene": "CRYBG3", "cells": [{"cohort": "mcl_idibips_2013", "status": "observed", "frequency": 6.9, "altered": 2, "tested": 29, "note": null}]}, {"label": "CHMP4C", "kind": "SNV / small indel", "gene": "CHMP4C", "cells": [{"cohort": "mcl_idibips_2013", "status": "observed", "frequency": 6.9, "altered": 2, "tested": 29, "note": null}]}, {"label": "BIRC3", "kind": "SNV / small indel", "gene": "BIRC3", "cells": [{"cohort": "mcl_idibips_2013", "status": "observed", "frequency": 6.9, "altered": 2, "tested": 29, "note": null}]}, {"label": "ABCC9", "kind": "SNV / small indel", "gene": "ABCC9", "cells": [{"cohort": "mcl_idibips_2013", "status": "observed", "frequency": 6.9, "altered": 2, "tested": 29, "note": null}]}]}