{
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      "nct": "NCT04661384",
      "title": "Brain Tumor-Specific Immune Cells (IL13Ralpha2-CAR T Cells) for the Treatment of Leptomeningeal Glioblastoma, Ependymoma, or Medulloblastoma",
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       "nct": "NCT04661384",
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     ]
    },
    "synonyms_searched": [
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   }
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     {
      "nct": "NCT01106508",
      "title": "A Dose Finding and Safety Study of Oral LEQ506 in Patients With Advanced Solid Tumors",
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      "last_update": "2020-12-17",
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    ]
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     {
      "nct": "NCT00880308",
      "title": "Dose Finding and Safety of Oral LDE225 in Patients With Advanced Solid Tumors",
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      "last_update": "2020-12-19",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01125800",
      "title": "A Phase I Dose Finding and Safety Study of Oral LDE225 in Children and a Phase II Portion to Assess Preliminary Efficacy in Recurrent or Refractory MB",
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     {
      "nct": "NCT01208831",
      "title": "An East Asian Study of LDE225",
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      "last_update": "2020-12-19",
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      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01708174",
      "title": "A Phase II Study of Oral LDE225 in Patients With Hedge-Hog (Hh)-Pathway Activated Relapsed Medulloblastoma (MB)",
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      "last_update": "2017-08-11",
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     },
     {
      "nct": "NCT03434262",
      "title": "SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors",
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      "last_update": "2024-05-31",
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      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT04402073",
      "title": "Personalized Risk-Adapted Therapy in Post-Pubertal Patients With Newly-Diagnosed Medulloblastoma",
      "status": "TERMINATED",
      "last_update": "2025-10-23",
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      "study_type": "INTERVENTIONAL"
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    ]
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      "nct": "NCT01697514",
      "title": "A Study of LY2940680 in Pediatric Medulloblastoma or Rhabdomyosarcoma",
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      "last_update": "2013-08-27",
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      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT05199584",
      "title": "A Study Evaluating the Safety and Efficacy of ENV-101 (Taladegib) in Patients With Advanced Solid Tumors Harboring PTCH1 Loss of Function Mutations",
      "status": "COMPLETED",
      "last_update": "2026-03-05",
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    ]
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    "trials": [
     {
      "nct": "NCT00822458",
      "title": "GDC-0449 in Treating Young Patients With Medulloblastoma That is Recurrent or Did Not Respond to Previous Treatment",
      "status": "COMPLETED",
      "last_update": "2014-04-02",
      "phase": "PHASE1",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT00939484",
      "title": "Vismodegib in Treating Patients With Recurrent or Refractory Medulloblastoma",
      "status": "COMPLETED",
      "last_update": "2016-02-25",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01239316",
      "title": "Vismodegib in Treating Younger Patients With Recurrent or Refractory Medulloblastoma",
      "status": "COMPLETED",
      "last_update": "2016-01-14",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01601184",
      "title": "Study of Vismodegib in Combination With Temozolomide Versus Temozolomide Alone in Patients With Medulloblastomas With an Activation of the Sonic Hedgehog Pathway",
      "status": "TERMINATED",
      "last_update": "2019-05-21",
      "phase": "PHASE1/PHASE2",
      "study_type": "INTERVENTIONAL"
     },
     {
      "nct": "NCT01878617",
      "title": "A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma",
      "status": "ACTIVE_NOT_RECRUITING",
      "last_update": "2025-11-13",
      "phase": "PHASE2",
      "study_type": "INTERVENTIONAL"
     }
    ]
   }
  }
 }
}