{"disease": {"name": "Mesothelioma", "mondo_id": null, "ncit_id": null, "umls_id": null, "oncotree_code": "plmeso"}, "updated_at": "2026-09-18", "genome_builds": ["hg19"], "cohort_count": 1, "cohort_count_status": "observed", "cohort_count_unit": "cohorts", "evaluable_patients": null, "evaluable_patients_status": "unknown", "evaluable_patients_unit": "patients", "alteration_types": ["SNV", "small indel", "amplification", "deep deletion"], "genes": [{"gene": "BAP1", "alteration_types": ["SNV / small indel", "deep deletion"], "altered": 18, "tested": 86, "frequency": 20.93, "cohort_count": 1, "frequency_range": {"min": 20.93, "max": 20.93}, "major_variants": ["I47Lfs*21 (n=1)", "E284* (n=1)", "Y418Wfs*9 (n=1)", "H169Tfs*18 (n=1)", "E182K (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Mesothelioma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=meso_tcga_pan_can_atlas_2018", "source_record_id": "meso_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Mesothelioma (TCGA, PanCancer Atlas), 18/86 patients (20.93%).", "Observed in 1 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "meso_tcga_pan_can_atlas_2018", "cohort_name": "Mesothelioma (TCGA, PanCancer Atlas)", "altered": 18, "tested": 86, "frequency": 20.93, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "86/87", "coverage_note": null, "source_id": "meso_tcga_pan_can_atlas_2018", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 69.77, "width": 1.0, "reference": 69.77, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 18, "tested": 86, "frequency": 20.93, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "CDKN2A", "alteration_types": ["deep deletion"], "altered": 0, "tested": 86, "frequency": 0.0, "cohort_count": 0, "frequency_range": {"min": 0.0, "max": 0.0}, "major_variants": [], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Mesothelioma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=meso_tcga_pan_can_atlas_2018", "source_record_id": "meso_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Mesothelioma (TCGA, PanCancer Atlas), 0/86 patients (0.0%).", "Largest alteration is deep deletion: 39/87 (44.83%) in the reference cohort's copy-number profile.", "Observed in 0 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "meso_tcga_pan_can_atlas_2018", "cohort_name": "Mesothelioma (TCGA, PanCancer Atlas)", "altered": 0, "tested": 86, "frequency": 0.0, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "86/87", "coverage_note": null, "source_id": "meso_tcga_pan_can_atlas_2018", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 100.0, "width": 1.0, "reference": 100.0, "scale_max": 30.0}, "headline_alteration": {"kind": "deep deletion", "altered": 39, "tested": 87, "frequency": 44.83, "is_mutation": false}, "altered_status": "not_observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "not_observed", "frequency_unit": "percent", "cohort_count_status": "not_observed", "cohort_count_unit": "cohorts"}, {"gene": "NF2", "alteration_types": ["SNV / small indel", "deep deletion"], "altered": 20, "tested": 86, "frequency": 23.26, "cohort_count": 1, "frequency_range": {"min": 23.26, "max": 23.26}, "major_variants": ["R57* (n=1)", "X333_splice (n=1)", "W184* (n=1)", "Y144* (n=1)", "K449Rfs*45 (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Mesothelioma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=meso_tcga_pan_can_atlas_2018", "source_record_id": "meso_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Mesothelioma (TCGA, PanCancer Atlas), 20/86 patients (23.26%).", "Observed in 1 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "meso_tcga_pan_can_atlas_2018", "cohort_name": "Mesothelioma (TCGA, PanCancer Atlas)", "altered": 20, "tested": 86, "frequency": 23.26, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "86/87", "coverage_note": null, "source_id": "meso_tcga_pan_can_atlas_2018", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 77.53, "width": 1.0, "reference": 77.53, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 20, "tested": 86, "frequency": 23.26, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "TP53", "alteration_types": ["SNV / small indel"], "altered": 14, "tested": 86, "frequency": 16.28, "cohort_count": 1, "frequency_range": {"min": 16.28, "max": 16.28}, "major_variants": ["K132N (n=1)", "A276D (n=1)", "R196* (n=1)", "R273C (n=1)", "Q331* (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Mesothelioma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=meso_tcga_pan_can_atlas_2018", "source_record_id": "meso_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Mesothelioma (TCGA, PanCancer Atlas), 14/86 patients (16.28%).", "Observed in 1 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "meso_tcga_pan_can_atlas_2018", "cohort_name": "Mesothelioma (TCGA, PanCancer Atlas)", "altered": 14, "tested": 86, "frequency": 16.28, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "86/87", "coverage_note": null, "source_id": "meso_tcga_pan_can_atlas_2018", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 54.27, "width": 1.0, "reference": 54.27, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 14, "tested": 86, "frequency": 16.28, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "SETD2", "alteration_types": ["SNV / small indel", "deep deletion"], "altered": 8, "tested": 86, "frequency": 9.3, "cohort_count": 1, "frequency_range": {"min": 9.3, "max": 9.3}, "major_variants": ["Q1998Rfs*3 (n=1)", "Q1287* (n=1)", "V1656F (n=1)", "T1753Nfs*36 (n=1)", "Q2142* (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Mesothelioma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=meso_tcga_pan_can_atlas_2018", "source_record_id": "meso_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Mesothelioma (TCGA, PanCancer Atlas), 8/86 patients (9.3%).", "Observed in 1 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "meso_tcga_pan_can_atlas_2018", "cohort_name": "Mesothelioma (TCGA, PanCancer Atlas)", "altered": 8, "tested": 86, "frequency": 9.3, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "86/87", "coverage_note": null, "source_id": "meso_tcga_pan_can_atlas_2018", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 31.0, "width": 1.0, "reference": 31.0, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 8, "tested": 86, "frequency": 9.3, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "LATS2", "alteration_types": ["SNV / small indel", "deep deletion"], "altered": 8, "tested": 86, "frequency": 9.3, "cohort_count": 1, "frequency_range": {"min": 9.3, "max": 9.3}, "major_variants": ["N654Lfs*40 (n=1)", "R593Afs*63 (n=1)", "K697* (n=1)", "E541* (n=1)", "R717W (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Mesothelioma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=meso_tcga_pan_can_atlas_2018", "source_record_id": "meso_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Mesothelioma (TCGA, PanCancer Atlas), 8/86 patients (9.3%).", "Observed in 1 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "meso_tcga_pan_can_atlas_2018", "cohort_name": "Mesothelioma (TCGA, PanCancer Atlas)", "altered": 8, "tested": 86, "frequency": 9.3, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "86/87", "coverage_note": null, "source_id": "meso_tcga_pan_can_atlas_2018", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 31.0, "width": 1.0, "reference": 31.0, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 8, "tested": 86, "frequency": 9.3, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "MSLN", "alteration_types": [], "altered": 0, "tested": 86, "frequency": 0.0, "cohort_count": 0, "frequency_range": {"min": 0.0, "max": 0.0}, "major_variants": [], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Mesothelioma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=meso_tcga_pan_can_atlas_2018", "source_record_id": "meso_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Mesothelioma (TCGA, PanCancer Atlas), 0/86 patients (0.0%).", "Observed in 0 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "meso_tcga_pan_can_atlas_2018", "cohort_name": "Mesothelioma (TCGA, PanCancer Atlas)", "altered": 0, "tested": 86, "frequency": 0.0, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "86/87", "coverage_note": null, "source_id": "meso_tcga_pan_can_atlas_2018", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 0.0, "width": 1.0, "reference": 0.0, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 0, "tested": 86, "frequency": 0.0, "is_mutation": true}, "altered_status": "not_observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "not_observed", "frequency_unit": "percent", "cohort_count_status": "not_observed", "cohort_count_unit": "cohorts"}, {"gene": "CD274", "alteration_types": ["SNV / small indel", "amplification"], "altered": 1, "tested": 86, "frequency": 1.16, "cohort_count": 1, "frequency_range": {"min": 1.16, "max": 1.16}, "major_variants": ["L224F (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Mesothelioma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=meso_tcga_pan_can_atlas_2018", "source_record_id": "meso_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Mesothelioma (TCGA, PanCancer Atlas), 1/86 patients (1.16%).", "Observed in 1 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "meso_tcga_pan_can_atlas_2018", "cohort_name": "Mesothelioma (TCGA, PanCancer Atlas)", "altered": 1, "tested": 86, "frequency": 1.16, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "86/87", "coverage_note": null, "source_id": "meso_tcga_pan_can_atlas_2018", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 3.87, "width": 1.0, "reference": 3.87, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 1, "tested": 86, "frequency": 1.16, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "PDCD1", "alteration_types": [], "altered": 0, "tested": 86, "frequency": 0.0, "cohort_count": 0, "frequency_range": {"min": 0.0, "max": 0.0}, "major_variants": [], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Mesothelioma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=meso_tcga_pan_can_atlas_2018", "source_record_id": "meso_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Mesothelioma (TCGA, PanCancer Atlas), 0/86 patients (0.0%).", "Observed in 0 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "meso_tcga_pan_can_atlas_2018", "cohort_name": "Mesothelioma (TCGA, PanCancer Atlas)", "altered": 0, "tested": 86, "frequency": 0.0, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "86/87", "coverage_note": null, "source_id": "meso_tcga_pan_can_atlas_2018", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 0.0, "width": 1.0, "reference": 0.0, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", 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"cBioPortal · Mesothelioma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=meso_tcga_pan_can_atlas_2018", "source_record_id": "meso_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Mesothelioma (TCGA, PanCancer Atlas), 0/86 patients (0.0%).", "Observed in 0 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "meso_tcga_pan_can_atlas_2018", "cohort_name": "Mesothelioma (TCGA, PanCancer Atlas)", "altered": 0, "tested": 86, "frequency": 0.0, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_observed", "assayed": true, 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30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 2, "tested": 86, "frequency": 2.33, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "TLN2", "alteration_types": ["SNV / small indel", "amplification"], "altered": 2, "tested": 86, "frequency": 2.33, "cohort_count": 1, "frequency_range": {"min": 2.33, "max": 2.33}, "major_variants": ["N1625S (n=1)", "G1094E (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Mesothelioma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=meso_tcga_pan_can_atlas_2018", "source_record_id": "meso_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Mesothelioma (TCGA, PanCancer Atlas), 2/86 patients (2.33%).", "Observed in 1 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "meso_tcga_pan_can_atlas_2018", "cohort_name": "Mesothelioma (TCGA, PanCancer Atlas)", "altered": 2, "tested": 86, "frequency": 2.33, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "86/87", "coverage_note": null, "source_id": "meso_tcga_pan_can_atlas_2018", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 7.77, "width": 1.0, "reference": 7.77, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 2, "tested": 86, "frequency": 2.33, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}], "variants": [], "genomic_events": [{"event_type": "copy_number", "gene": "CDKN2A", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "deep deletion", "event_label": "CDKN2A deep deletion", "genomic_coordinate": null, "observed": 39, "observed_status": "observed", "observed_unit": "patients", "tested": 87, "tested_status": "observed", "tested_unit": "patients", "frequency": 44.83, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["meso_tcga_pan_can_atlas_2018"], "source_ids": ["meso_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "BAP1", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "deep deletion", "event_label": "BAP1 deep deletion", "genomic_coordinate": null, "observed": 10, "observed_status": "observed", "observed_unit": "patients", "tested": 87, "tested_status": "observed", "tested_unit": "patients", "frequency": 11.49, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["meso_tcga_pan_can_atlas_2018"], "source_ids": ["meso_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "NF2", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "deep deletion", "event_label": "NF2 deep deletion", "genomic_coordinate": null, "observed": 7, "observed_status": "observed", "observed_unit": "patients", "tested": 87, "tested_status": "observed", "tested_unit": "patients", "frequency": 8.05, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["meso_tcga_pan_can_atlas_2018"], "source_ids": ["meso_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "MGA", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "deep deletion", "event_label": "MGA deep deletion", "genomic_coordinate": null, "observed": 4, "observed_status": "observed", "observed_unit": "patients", "tested": 87, "tested_status": "observed", "tested_unit": "patients", "frequency": 4.6, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["meso_tcga_pan_can_atlas_2018"], "source_ids": ["meso_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "ALPK3", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "ALPK3 amplification", "genomic_coordinate": null, "observed": 4, "observed_status": "observed", "observed_unit": "patients", "tested": 87, "tested_status": "observed", "tested_unit": "patients", "frequency": 4.6, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["meso_tcga_pan_can_atlas_2018"], "source_ids": ["meso_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "SETD2", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "deep deletion", "event_label": "SETD2 deep deletion", "genomic_coordinate": null, "observed": 3, "observed_status": "observed", "observed_unit": "patients", "tested": 87, "tested_status": "observed", "tested_unit": "patients", "frequency": 3.45, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["meso_tcga_pan_can_atlas_2018"], "source_ids": ["meso_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "NLRP9", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "NLRP9 amplification", "genomic_coordinate": null, "observed": 2, "observed_status": "observed", "observed_unit": "patients", "tested": 87, "tested_status": "observed", "tested_unit": "patients", "frequency": 2.3, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["meso_tcga_pan_can_atlas_2018"], "source_ids": ["meso_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "VPS13C", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "VPS13C amplification", "genomic_coordinate": null, "observed": 2, "observed_status": "observed", "observed_unit": "patients", "tested": 87, "tested_status": "observed", "tested_unit": "patients", "frequency": 2.3, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["meso_tcga_pan_can_atlas_2018"], "source_ids": ["meso_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "USP9X", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "deep deletion", "event_label": "USP9X deep deletion", "genomic_coordinate": null, "observed": 2, "observed_status": "observed", "observed_unit": "patients", "tested": 87, "tested_status": "observed", "tested_unit": "patients", "frequency": 2.3, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["meso_tcga_pan_can_atlas_2018"], "source_ids": ["meso_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "TLN2", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "TLN2 amplification", "genomic_coordinate": null, "observed": 2, "observed_status": "observed", "observed_unit": "patients", "tested": 87, "tested_status": "observed", "tested_unit": "patients", "frequency": 2.3, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["meso_tcga_pan_can_atlas_2018"], "source_ids": ["meso_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}], "modality_summary": [{"modality": "SNV / small indel", "available_cohorts": 1, "total_cohorts": 1}, {"modality": "Copy number (discrete)", "available_cohorts": 1, "total_cohorts": 1}, {"modality": "Structural variant (present, not read)", "available_cohorts": 1, "total_cohorts": 1}], "chromosome_summary": [], "cohorts": [{"name": "Mesothelioma (TCGA, PanCancer Atlas)", "source": "cBioPortal", "accession": "meso_tcga_pan_can_atlas_2018", "patients": {"value": 86, "status": "observed", "unit": "patients"}, "samples": {"value": 86, "status": "observed", "unit": "samples"}, "disease_subtype": "Mesothelioma (TCGA, PanCancer Atlas)", "assay_type": "exome or genome", "sequencing_method": "WES (86)", "genome_build": "hg19", "alteration_types_available": ["SNV", "small indel", "amplification", "deep deletion", "structural variant (profile present, not read)"], "genes_assayed": "all coding genes", "primary_or_metastatic": null, "age_group": null, "retrieved_at": "2026-09-18", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "source_record_id": "meso_tcga_pan_can_atlas_2018", "is_demo": false, "assay_coverage": {"patients_with_calls": 86, "patients_in_roster": 86, "frequencies_computed": true, "samples_sequenced": 86, "samples_in_study": 87, "hypermutated_patients": 0, "median_mutations_per_sample": 26.0, "reason": null}}], "sources": [{"source_name": "cBioPortal · Mesothelioma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=meso_tcga_pan_can_atlas_2018", "source_record_id": "meso_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "limitations": ["A cBioPortal public-API snapshot retrieved 2026-09-18; the page does not refresh source data at request time.", "Counts are patients with at least one non-silent call in the study's sequenced sample list; silent, intronic and UTR calls are excluded.", "For targeted-panel cohorts each gene divides by the patients whose panel carried it; a gene absent from the panel is shown as not assayed, not as zero.", "Copy-number rows use discrete calls (2 = high-level amplification, −2 = deep deletion) against the cohort's copy-number sample list, which is a different roster from the sequenced one.", "Cohorts are not pooled. Cross-study patient overlap has not been checked and no disease-wide frequency is reported.", "Structural variants and fusions are not read in this snapshot even where the study carries a profile; germline variants, mutational signatures, TMB and MSI are not reported.", "The gene set is the briefing's curated targets plus the reference cohort's most frequently mutated genes; it is not genome-wide."], "answer_block": ["In Mesothelioma (TCGA, PanCancer Atlas) (86 sequenced patients, exome or genome), the most frequently altered of the 47 genes shown are CDKN2A 44.83% (deep deletion), NF2 23.26%, BAP1 20.93%, TP53 16.28%, SETD2 9.3%. Each figure divides by the patients on whom that gene could be called.", "Of the briefing's 12 curated targets, 6 are altered in under 2% of this cohort (MSLN, CD274, PDCD1, CTLA4, VEGFA, ALK): targets by expression, dependency or drug label, not by mutation. Frequency is not targetability, in either direction.", "1 cohorts are shown and none are pooled; overlap between them has not been checked and there is no disease-wide percentage."], "key_findings": [{"finding": "CDKN2A is deleted in 39 of 87 patients in Mesothelioma (TCGA, PanCancer Atlas).", "numerator": 39, "denominator": 87, "frequency": 44.83, "cohorts": 0, "evidence_confidence": "moderate", "source": "meso_tcga_pan_can_atlas_2018", "retrieved_at": "2026-09-18"}, {"finding": "NF2 is mutated in 20 of 86 patients in Mesothelioma (TCGA, PanCancer Atlas).", "numerator": 20, "denominator": 86, "frequency": 23.26, "cohorts": 1, "evidence_confidence": "moderate", "source": "meso_tcga_pan_can_atlas_2018", "retrieved_at": "2026-09-18"}, {"finding": "BAP1 is mutated in 18 of 86 patients in Mesothelioma (TCGA, PanCancer Atlas).", "numerator": 18, "denominator": 86, "frequency": 20.93, "cohorts": 1, "evidence_confidence": "moderate", "source": "meso_tcga_pan_can_atlas_2018", "retrieved_at": "2026-09-18"}], "research_gaps": [{"kind": "Structural variants", "text": "Read the structural-variant profiles the studies carry; fusions are the defining event in several of these diseases."}, {"kind": "Context", "text": "Stage, subtype, age and treatment line are not attached to any count; the cohorts differ on all four."}, {"kind": "Interpretation", "text": "Activating versus inactivating, actionable versus not, and evidence level are not inferred here; the briefing's target table carries the drug and trial facts."}], "observations": [], "data_status": "PUBLIC SOURCE SNAPSHOT", "is_demo": false, "reference_cohort": "meso_tcga_pan_can_atlas_2018", "region_events": [], "matrix": [{"label": "BAP1", "kind": "SNV / small indel", "gene": "BAP1", "cells": [{"cohort": "meso_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 20.93, "altered": 18, "tested": 86, "note": null}]}, {"label": "BAP1", "kind": "deep deletion", "gene": "BAP1", "cells": [{"cohort": "meso_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 11.49, "altered": 10, "tested": 87, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "CDKN2A", "kind": "SNV / small indel", "gene": "CDKN2A", "cells": [{"cohort": "meso_tcga_pan_can_atlas_2018", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 86, "note": null}]}, {"label": "CDKN2A", "kind": "deep deletion", "gene": "CDKN2A", "cells": [{"cohort": "meso_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 44.83, "altered": 39, "tested": 87, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "NF2", "kind": "SNV / small indel", "gene": "NF2", "cells": [{"cohort": "meso_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 23.26, "altered": 20, "tested": 86, "note": null}]}, {"label": "NF2", "kind": "deep deletion", "gene": "NF2", "cells": [{"cohort": "meso_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 8.05, "altered": 7, "tested": 87, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "TP53", "kind": "SNV / small indel", "gene": "TP53", "cells": [{"cohort": "meso_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 16.28, "altered": 14, "tested": 86, "note": null}]}, {"label": "SETD2", "kind": "SNV / small indel", "gene": "SETD2", "cells": [{"cohort": "meso_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 9.3, "altered": 8, "tested": 86, "note": null}]}, {"label": "SETD2", "kind": "deep deletion", "gene": "SETD2", "cells": [{"cohort": "meso_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.45, "altered": 3, "tested": 87, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "LATS2", "kind": "SNV / small indel", "gene": "LATS2", "cells": [{"cohort": "meso_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 9.3, "altered": 8, "tested": 86, "note": null}]}, {"label": "MSLN", "kind": "SNV / small indel", "gene": "MSLN", "cells": [{"cohort": "meso_tcga_pan_can_atlas_2018", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 86, "note": null}]}, {"label": "CD274", "kind": "SNV / small indel", "gene": "CD274", "cells": [{"cohort": "meso_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 1.16, "altered": 1, "tested": 86, "note": null}]}, {"label": "PDCD1", "kind": "SNV / small indel", "gene": "PDCD1", "cells": [{"cohort": "meso_tcga_pan_can_atlas_2018", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 86, "note": null}]}, {"label": "CTLA4", "kind": "SNV / small indel", "gene": "CTLA4", "cells": [{"cohort": "meso_tcga_pan_can_atlas_2018", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 86, "note": null}]}, {"label": "VEGFA", "kind": "SNV / small indel", "gene": "VEGFA", "cells": [{"cohort": "meso_tcga_pan_can_atlas_2018", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 86, "note": null}]}, {"label": "ALK", "kind": "SNV / small indel", "gene": "ALK", "cells": [{"cohort": "meso_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 1.16, "altered": 1, "tested": 86, "note": null}]}, {"label": "WWP2", "kind": "SNV / small indel", "gene": "WWP2", "cells": [{"cohort": "meso_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.49, "altered": 3, "tested": 86, "note": null}]}, {"label": "VWF", "kind": "SNV / small indel", "gene": "VWF", "cells": [{"cohort": "meso_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.49, "altered": 3, "tested": 86, "note": null}]}, {"label": "TDRD6", "kind": "SNV / small indel", "gene": "TDRD6", "cells": [{"cohort": "meso_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.49, "altered": 3, "tested": 86, "note": null}]}, {"label": "SRGAP3", "kind": "SNV / small indel", "gene": "SRGAP3", "cells": [{"cohort": "meso_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.49, "altered": 3, "tested": 86, "note": null}]}, {"label": "SHROOM1", "kind": "SNV / small indel", "gene": "SHROOM1", "cells": [{"cohort": "meso_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.49, "altered": 3, "tested": 86, "note": null}]}, {"label": "SETDB1", "kind": "SNV / small indel", "gene": "SETDB1", "cells": [{"cohort": "meso_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.49, "altered": 3, "tested": 86, "note": null}]}, {"label": "SDK1", "kind": "SNV / small indel", "gene": "SDK1", "cells": [{"cohort": "meso_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.49, "altered": 3, "tested": 86, "note": null}]}, {"label": "PTCH1", "kind": "SNV / small indel", "gene": "PTCH1", "cells": [{"cohort": "meso_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.49, "altered": 3, "tested": 86, "note": null}]}, {"label": "PHRF1", "kind": "SNV / small indel", "gene": "PHRF1", "cells": [{"cohort": "meso_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.49, "altered": 3, "tested": 86, "note": null}]}, {"label": "OGDHL", "kind": "SNV / small indel", "gene": "OGDHL", "cells": [{"cohort": "meso_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.49, "altered": 3, "tested": 86, "note": null}]}, {"label": "NLRP9", "kind": "SNV / small indel", "gene": "NLRP9", "cells": [{"cohort": "meso_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.49, "altered": 3, "tested": 86, "note": null}]}, {"label": "NLRP9", "kind": "amplification", "gene": "NLRP9", "cells": [{"cohort": "meso_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 2.3, "altered": 2, "tested": 87, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "NLRP7", "kind": "SNV / small indel", "gene": "NLRP7", "cells": [{"cohort": "meso_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.49, "altered": 3, "tested": 86, "note": null}]}, {"label": "NEXMIF", "kind": "SNV / small indel", "gene": "NEXMIF", "cells": [{"cohort": "meso_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.49, "altered": 3, "tested": 86, "note": null}]}, {"label": "NDST2", "kind": "SNV / small indel", "gene": "NDST2", "cells": [{"cohort": "meso_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.49, "altered": 3, "tested": 86, "note": null}]}, {"label": "NCOR1", "kind": "SNV / small indel", "gene": "NCOR1", "cells": [{"cohort": "meso_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.49, "altered": 3, "tested": 86, "note": null}]}, {"label": "MROH2B", "kind": "SNV / small indel", "gene": "MROH2B", "cells": [{"cohort": "meso_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.49, "altered": 3, "tested": 86, "note": null}]}, {"label": "MGA", "kind": "SNV / small indel", "gene": "MGA", "cells": [{"cohort": "meso_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.49, "altered": 3, "tested": 86, "note": null}]}, {"label": "MGA", "kind": "deep deletion", "gene": "MGA", "cells": [{"cohort": "meso_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 4.6, "altered": 4, "tested": 87, "note": "Discrete copy-number call; 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