{"disease": {"name": "Multiple myeloma", "mondo_id": null, "ncit_id": null, "umls_id": null, "oncotree_code": "pcm"}, "updated_at": "2026-09-18", "genome_builds": ["hg19"], "cohort_count": 1, "cohort_count_status": "observed", "cohort_count_unit": "cohorts", "evaluable_patients": null, "evaluable_patients_status": "unknown", "evaluable_patients_unit": "patients", "alteration_types": ["SNV", "small indel", "amplification", "deep deletion"], "genes": [{"gene": "TNFRSF17", "alteration_types": [], "altered": 0, "tested": 205, "frequency": 0.0, "cohort_count": 0, "frequency_range": {"min": 0.0, "max": 0.0}, "major_variants": [], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Multiple Myeloma (Broad, Cancer Cell 2014)", "source_url": "https://www.cbioportal.org/study/summary?id=mm_broad", "source_record_id": "mm_broad", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Multiple Myeloma (Broad, Cancer Cell 2014), 0/205 patients (0.0%).", "Without the 1 hypermutated patients: 0/204 (0.0%).", "Observed in 0 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "mm_broad", "cohort_name": "Multiple Myeloma (Broad, Cancer Cell 2014)", "altered": 0, "tested": 205, "frequency": 0.0, "frequency_excl_hypermutated": 0.0, "counting_unit": "patients", "status": "not_observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "205/211", "coverage_note": null, "source_id": "mm_broad", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 0.0, "width": 1.0, "reference": 0.0, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 0, "tested": 205, "frequency": 0.0, "is_mutation": true}, "altered_status": "not_observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "not_observed", "frequency_unit": "percent", "cohort_count_status": "not_observed", "cohort_count_unit": "cohorts"}, {"gene": "GPRC5D", "alteration_types": [], "altered": 0, "tested": 205, "frequency": 0.0, "cohort_count": 0, "frequency_range": {"min": 0.0, "max": 0.0}, "major_variants": [], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Multiple Myeloma (Broad, Cancer Cell 2014)", "source_url": "https://www.cbioportal.org/study/summary?id=mm_broad", "source_record_id": "mm_broad", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Multiple Myeloma (Broad, Cancer Cell 2014), 0/205 patients (0.0%).", "Without the 1 hypermutated patients: 0/204 (0.0%).", "Observed in 0 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "mm_broad", "cohort_name": "Multiple Myeloma (Broad, Cancer Cell 2014)", "altered": 0, "tested": 205, "frequency": 0.0, "frequency_excl_hypermutated": 0.0, "counting_unit": "patients", "status": "not_observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "205/211", "coverage_note": null, "source_id": "mm_broad", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 0.0, "width": 1.0, "reference": 0.0, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 0, "tested": 205, "frequency": 0.0, "is_mutation": true}, "altered_status": "not_observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "not_observed", "frequency_unit": "percent", "cohort_count_status": "not_observed", "cohort_count_unit": "cohorts"}, {"gene": "FCRL5", "alteration_types": [], "altered": 0, "tested": 205, "frequency": 0.0, "cohort_count": 0, "frequency_range": {"min": 0.0, "max": 0.0}, "major_variants": [], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Multiple Myeloma (Broad, Cancer Cell 2014)", "source_url": "https://www.cbioportal.org/study/summary?id=mm_broad", "source_record_id": "mm_broad", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Multiple Myeloma (Broad, Cancer Cell 2014), 0/205 patients (0.0%).", "Without the 1 hypermutated patients: 0/204 (0.0%).", "Observed in 0 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "mm_broad", "cohort_name": "Multiple Myeloma (Broad, Cancer Cell 2014)", "altered": 0, "tested": 205, "frequency": 0.0, "frequency_excl_hypermutated": 0.0, "counting_unit": "patients", "status": "not_observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "205/211", "coverage_note": null, "source_id": "mm_broad", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 0.0, "width": 1.0, "reference": 0.0, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 0, "tested": 205, "frequency": 0.0, "is_mutation": true}, "altered_status": "not_observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "not_observed", "frequency_unit": "percent", "cohort_count_status": "not_observed", "cohort_count_unit": "cohorts"}, {"gene": "CD38", "alteration_types": [], "altered": 0, "tested": 205, "frequency": 0.0, "cohort_count": 0, "frequency_range": {"min": 0.0, "max": 0.0}, "major_variants": [], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Multiple Myeloma (Broad, Cancer Cell 2014)", "source_url": "https://www.cbioportal.org/study/summary?id=mm_broad", "source_record_id": "mm_broad", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Multiple Myeloma (Broad, Cancer Cell 2014), 0/205 patients (0.0%).", "Without the 1 hypermutated patients: 0/204 (0.0%).", "Observed in 0 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "mm_broad", "cohort_name": "Multiple Myeloma (Broad, Cancer Cell 2014)", "altered": 0, "tested": 205, "frequency": 0.0, "frequency_excl_hypermutated": 0.0, "counting_unit": "patients", "status": "not_observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "205/211", "coverage_note": null, "source_id": "mm_broad", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 0.0, "width": 1.0, "reference": 0.0, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 0, "tested": 205, "frequency": 0.0, "is_mutation": true}, "altered_status": "not_observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "not_observed", "frequency_unit": "percent", "cohort_count_status": "not_observed", "cohort_count_unit": "cohorts"}, {"gene": "SLAMF7", "alteration_types": [], "altered": 0, "tested": 205, "frequency": 0.0, "cohort_count": 0, "frequency_range": {"min": 0.0, "max": 0.0}, "major_variants": [], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Multiple Myeloma (Broad, Cancer Cell 2014)", "source_url": "https://www.cbioportal.org/study/summary?id=mm_broad", "source_record_id": "mm_broad", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Multiple Myeloma (Broad, Cancer Cell 2014), 0/205 patients (0.0%).", "Without the 1 hypermutated patients: 0/204 (0.0%).", "Observed in 0 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "mm_broad", "cohort_name": "Multiple Myeloma (Broad, Cancer Cell 2014)", "altered": 0, "tested": 205, "frequency": 0.0, "frequency_excl_hypermutated": 0.0, "counting_unit": "patients", "status": "not_observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "205/211", "coverage_note": null, "source_id": "mm_broad", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 0.0, "width": 1.0, "reference": 0.0, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 0, "tested": 205, "frequency": 0.0, "is_mutation": true}, "altered_status": "not_observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "not_observed", "frequency_unit": "percent", "cohort_count_status": "not_observed", "cohort_count_unit": "cohorts"}, {"gene": "CRBN", "alteration_types": ["SNV / small indel"], "altered": 1, "tested": 205, "frequency": 0.49, "cohort_count": 1, "frequency_range": {"min": 0.49, "max": 0.49}, "major_variants": ["R111Q (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Multiple Myeloma (Broad, Cancer Cell 2014)", "source_url": "https://www.cbioportal.org/study/summary?id=mm_broad", "source_record_id": "mm_broad", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Multiple Myeloma (Broad, Cancer Cell 2014), 1/205 patients (0.49%).", "Without the 1 hypermutated patients: 1/204 (0.49%).", "Observed in 1 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "mm_broad", "cohort_name": "Multiple Myeloma (Broad, Cancer Cell 2014)", "altered": 1, "tested": 205, "frequency": 0.49, "frequency_excl_hypermutated": 0.49, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "205/211", "coverage_note": null, "source_id": "mm_broad", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 1.63, "width": 1.0, "reference": 1.63, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 1, "tested": 205, "frequency": 0.49, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "PSMB5", "alteration_types": [], "altered": 0, "tested": 205, "frequency": 0.0, "cohort_count": 0, "frequency_range": {"min": 0.0, "max": 0.0}, "major_variants": [], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Multiple Myeloma (Broad, Cancer Cell 2014)", "source_url": "https://www.cbioportal.org/study/summary?id=mm_broad", "source_record_id": "mm_broad", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Multiple Myeloma (Broad, Cancer Cell 2014), 0/205 patients (0.0%).", "Without the 1 hypermutated patients: 0/204 (0.0%).", "Observed in 0 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "mm_broad", "cohort_name": "Multiple Myeloma (Broad, Cancer Cell 2014)", "altered": 0, "tested": 205, "frequency": 0.0, "frequency_excl_hypermutated": 0.0, "counting_unit": "patients", "status": "not_observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "205/211", "coverage_note": null, "source_id": "mm_broad", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 0.0, "width": 1.0, "reference": 0.0, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 0, "tested": 205, "frequency": 0.0, "is_mutation": true}, "altered_status": "not_observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "not_observed", "frequency_unit": "percent", "cohort_count_status": "not_observed", "cohort_count_unit": "cohorts"}, {"gene": "XPO1", "alteration_types": [], "altered": 0, "tested": 205, "frequency": 0.0, "cohort_count": 0, "frequency_range": {"min": 0.0, "max": 0.0}, "major_variants": [], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Multiple Myeloma (Broad, Cancer Cell 2014)", "source_url": "https://www.cbioportal.org/study/summary?id=mm_broad", "source_record_id": "mm_broad", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Multiple Myeloma (Broad, Cancer Cell 2014), 0/205 patients (0.0%).", "Without the 1 hypermutated patients: 0/204 (0.0%).", "Observed in 0 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "mm_broad", "cohort_name": "Multiple Myeloma (Broad, Cancer Cell 2014)", "altered": 0, "tested": 205, "frequency": 0.0, "frequency_excl_hypermutated": 0.0, "counting_unit": "patients", "status": "not_observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "205/211", "coverage_note": null, "source_id": "mm_broad", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 0.0, "width": 1.0, "reference": 0.0, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 0, "tested": 205, "frequency": 0.0, "is_mutation": true}, "altered_status": "not_observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "not_observed", "frequency_unit": "percent", "cohort_count_status": "not_observed", "cohort_count_unit": "cohorts"}, {"gene": "KRAS", "alteration_types": ["SNV / small indel"], "altered": 45, "tested": 205, "frequency": 21.95, "cohort_count": 1, "frequency_range": {"min": 21.95, "max": 21.95}, "major_variants": ["Q61H (n=10)", "G13D (n=9)", "A146T (n=3)", "G12A (n=3)", "G12D (n=3)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Multiple Myeloma (Broad, Cancer Cell 2014)", "source_url": "https://www.cbioportal.org/study/summary?id=mm_broad", "source_record_id": "mm_broad", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Multiple Myeloma (Broad, Cancer Cell 2014), 45/205 patients (21.95%).", "Without the 1 hypermutated patients: 45/204 (22.06%).", "Observed in 1 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "mm_broad", "cohort_name": "Multiple Myeloma (Broad, Cancer Cell 2014)", "altered": 45, "tested": 205, "frequency": 21.95, "frequency_excl_hypermutated": 22.06, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "205/211", "coverage_note": null, "source_id": "mm_broad", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 73.17, "width": 1.0, "reference": 73.17, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 45, "tested": 205, "frequency": 21.95, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "NRAS", "alteration_types": ["SNV / small indel"], "altered": 37, "tested": 205, "frequency": 18.05, "cohort_count": 1, "frequency_range": {"min": 18.05, "max": 18.05}, "major_variants": ["Q61R (n=11)", "Q61K (n=9)", "Q61H (n=5)", "G13R (n=4)", "Q61L (n=2)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Multiple Myeloma (Broad, Cancer Cell 2014)", "source_url": "https://www.cbioportal.org/study/summary?id=mm_broad", "source_record_id": "mm_broad", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Multiple Myeloma (Broad, Cancer Cell 2014), 37/205 patients (18.05%).", "Without the 1 hypermutated patients: 37/204 (18.14%).", "Observed in 1 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "mm_broad", "cohort_name": "Multiple Myeloma (Broad, Cancer Cell 2014)", "altered": 37, "tested": 205, "frequency": 18.05, "frequency_excl_hypermutated": 18.14, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "205/211", "coverage_note": null, "source_id": "mm_broad", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 60.17, "width": 1.0, "reference": 60.17, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 37, "tested": 205, "frequency": 18.05, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "TP53", "alteration_types": ["SNV / small indel"], "altered": 15, "tested": 205, "frequency": 7.32, "cohort_count": 1, "frequency_range": {"min": 7.32, "max": 7.32}, "major_variants": ["E51* (n=1)", "D281V (n=1)", "C275S (n=1)", "Y205D (n=1)", "R196* (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Multiple Myeloma (Broad, Cancer Cell 2014)", "source_url": "https://www.cbioportal.org/study/summary?id=mm_broad", "source_record_id": "mm_broad", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Multiple Myeloma (Broad, Cancer Cell 2014), 15/205 patients (7.32%).", "Without the 1 hypermutated patients: 15/204 (7.35%).", "Observed in 1 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "mm_broad", "cohort_name": "Multiple Myeloma (Broad, Cancer Cell 2014)", "altered": 15, "tested": 205, "frequency": 7.32, "frequency_excl_hypermutated": 7.35, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "205/211", "coverage_note": null, "source_id": "mm_broad", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 24.4, "width": 1.0, "reference": 24.4, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 15, "tested": 205, "frequency": 7.32, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "NSD2", "alteration_types": ["SNV / small indel"], "altered": 5, "tested": 205, "frequency": 2.44, "cohort_count": 1, "frequency_range": {"min": 2.44, "max": 2.44}, "major_variants": ["C1191F (n=1)", "A332D (n=1)", "E1099K (n=1)", "R1138G (n=1)", "S1314C (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Multiple Myeloma (Broad, Cancer Cell 2014)", "source_url": "https://www.cbioportal.org/study/summary?id=mm_broad", "source_record_id": "mm_broad", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Multiple Myeloma (Broad, Cancer Cell 2014), 5/205 patients (2.44%).", "Without the 1 hypermutated patients: 5/204 (2.45%).", "Observed in 1 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "mm_broad", "cohort_name": "Multiple Myeloma (Broad, Cancer Cell 2014)", "altered": 5, "tested": 205, "frequency": 2.44, "frequency_excl_hypermutated": 2.45, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "205/211", "coverage_note": null, "source_id": "mm_broad", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 8.13, "width": 1.0, "reference": 8.13, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 5, "tested": 205, "frequency": 2.44, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "CCND1", "alteration_types": ["SNV / small indel"], "altered": 7, "tested": 205, "frequency": 3.41, "cohort_count": 1, "frequency_range": {"min": 3.41, "max": 3.41}, "major_variants": ["Q4R (n=1)", "K46N (n=1)", "P54A (n=1)", "C8Y (n=1)", "E135D (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Multiple Myeloma (Broad, Cancer Cell 2014)", "source_url": "https://www.cbioportal.org/study/summary?id=mm_broad", "source_record_id": "mm_broad", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Multiple Myeloma (Broad, Cancer Cell 2014), 7/205 patients (3.41%).", "Without the 1 hypermutated patients: 7/204 (3.43%).", "Observed in 1 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "mm_broad", "cohort_name": "Multiple Myeloma (Broad, Cancer Cell 2014)", "altered": 7, "tested": 205, "frequency": 3.41, "frequency_excl_hypermutated": 3.43, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "205/211", "coverage_note": null, "source_id": "mm_broad", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 11.37, "width": 1.0, "reference": 11.37, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 7, "tested": 205, "frequency": 3.41, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "MYC", "alteration_types": ["SNV / small indel"], "altered": 2, "tested": 205, "frequency": 0.98, "cohort_count": 1, "frequency_range": {"min": 0.98, "max": 0.98}, "major_variants": ["Q35E (n=1)", "V160I (n=1)", "S218T (n=1)", "S217N (n=1)", "D32N (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Multiple Myeloma (Broad, Cancer Cell 2014)", "source_url": "https://www.cbioportal.org/study/summary?id=mm_broad", "source_record_id": "mm_broad", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Multiple Myeloma (Broad, Cancer Cell 2014), 2/205 patients (0.98%).", "Without the 1 hypermutated patients: 1/204 (0.49%).", "Observed in 1 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "mm_broad", "cohort_name": "Multiple Myeloma (Broad, Cancer Cell 2014)", "altered": 2, "tested": 205, "frequency": 0.98, "frequency_excl_hypermutated": 0.49, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "205/211", "coverage_note": null, "source_id": "mm_broad", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 3.27, "width": 1.0, "reference": 3.27, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 2, "tested": 205, "frequency": 0.98, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "DIS3", "alteration_types": ["SNV / small indel"], "altered": 19, "tested": 205, "frequency": 9.27, "cohort_count": 1, "frequency_range": {"min": 9.27, "max": 9.27}, "major_variants": ["R780K (n=2)", "R351K (n=1)", "F775L (n=1)", "S477R (n=1)", "V504G (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Multiple Myeloma (Broad, Cancer Cell 2014)", "source_url": "https://www.cbioportal.org/study/summary?id=mm_broad", "source_record_id": "mm_broad", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Multiple Myeloma (Broad, Cancer Cell 2014), 19/205 patients (9.27%).", "Without the 1 hypermutated patients: 19/204 (9.31%).", "Observed in 1 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "mm_broad", "cohort_name": "Multiple Myeloma (Broad, Cancer Cell 2014)", "altered": 19, "tested": 205, "frequency": 9.27, "frequency_excl_hypermutated": 9.31, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "205/211", "coverage_note": null, "source_id": "mm_broad", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 30.9, "width": 1.0, "reference": 30.9, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 19, "tested": 205, "frequency": 9.27, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "TENT5C", "alteration_types": ["SNV / small indel"], "altered": 15, "tested": 205, "frequency": 7.32, "cohort_count": 1, "frequency_range": {"min": 7.32, "max": 7.32}, "major_variants": ["S203C (n=1)", "D90H (n=1)", "D182Y (n=1)", "I187del (n=1)", "V314G (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Multiple Myeloma (Broad, Cancer Cell 2014)", "source_url": "https://www.cbioportal.org/study/summary?id=mm_broad", "source_record_id": "mm_broad", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Multiple Myeloma (Broad, Cancer Cell 2014), 15/205 patients (7.32%).", "Without the 1 hypermutated patients: 15/204 (7.35%).", "Observed in 1 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "mm_broad", "cohort_name": "Multiple Myeloma (Broad, Cancer Cell 2014)", "altered": 15, "tested": 205, "frequency": 7.32, "frequency_excl_hypermutated": 7.35, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "205/211", "coverage_note": null, "source_id": "mm_broad", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 24.4, "width": 1.0, "reference": 24.4, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 15, "tested": 205, "frequency": 7.32, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "BRAF", "alteration_types": ["SNV / small indel"], "altered": 13, "tested": 205, "frequency": 6.34, "cohort_count": 1, "frequency_range": {"min": 6.34, "max": 6.34}, "major_variants": ["V600E (n=5)", "G469A (n=2)", "G469V (n=1)", "N581S (n=1)", "G466E (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Multiple Myeloma (Broad, Cancer Cell 2014)", "source_url": "https://www.cbioportal.org/study/summary?id=mm_broad", "source_record_id": "mm_broad", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Multiple Myeloma (Broad, Cancer Cell 2014), 13/205 patients (6.34%).", "Without the 1 hypermutated patients: 12/204 (5.88%).", "Observed in 1 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "mm_broad", "cohort_name": "Multiple Myeloma (Broad, Cancer Cell 2014)", "altered": 13, "tested": 205, "frequency": 6.34, "frequency_excl_hypermutated": 5.88, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "205/211", "coverage_note": null, "source_id": "mm_broad", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 21.13, "width": 1.0, "reference": 21.13, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 13, "tested": 205, "frequency": 6.34, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "TRIO", "alteration_types": ["SNV / small indel"], "altered": 9, "tested": 205, "frequency": 4.39, "cohort_count": 1, "frequency_range": {"min": 4.39, "max": 4.39}, "major_variants": ["X2155_splice (n=1)", "E1216D (n=1)", "I957T (n=1)", "V727M (n=1)", "V534M (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Multiple Myeloma (Broad, Cancer Cell 2014)", "source_url": "https://www.cbioportal.org/study/summary?id=mm_broad", "source_record_id": "mm_broad", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Multiple Myeloma (Broad, Cancer Cell 2014), 9/205 patients (4.39%).", "Without the 1 hypermutated patients: 9/204 (4.41%).", "Observed in 1 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "mm_broad", "cohort_name": "Multiple Myeloma (Broad, Cancer Cell 2014)", "altered": 9, "tested": 205, "frequency": 4.39, "frequency_excl_hypermutated": 4.41, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "205/211", "coverage_note": null, "source_id": "mm_broad", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 14.63, "width": 1.0, "reference": 14.63, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 9, "tested": 205, "frequency": 4.39, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "SVIL", "alteration_types": ["SNV / small indel"], "altered": 8, "tested": 205, "frequency": 3.9, "cohort_count": 1, "frequency_range": {"min": 3.9, "max": 3.9}, "major_variants": ["A1661V (n=1)", "R541H (n=1)", "K454* (n=1)", "E1521K (n=1)", "D462N (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Multiple Myeloma (Broad, Cancer Cell 2014)", "source_url": "https://www.cbioportal.org/study/summary?id=mm_broad", "source_record_id": "mm_broad", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Multiple Myeloma (Broad, Cancer Cell 2014), 8/205 patients (3.9%).", "Without the 1 hypermutated patients: 7/204 (3.43%).", "Observed in 1 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "mm_broad", "cohort_name": "Multiple Myeloma (Broad, Cancer Cell 2014)", "altered": 8, "tested": 205, "frequency": 3.9, "frequency_excl_hypermutated": 3.43, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "205/211", "coverage_note": null, "source_id": "mm_broad", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 13.0, "width": 1.0, "reference": 13.0, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 8, "tested": 205, "frequency": 3.9, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "KALRN", "alteration_types": ["SNV / small indel"], "altered": 8, "tested": 205, "frequency": 3.9, "cohort_count": 1, "frequency_range": {"min": 3.9, "max": 3.9}, "major_variants": ["Y1153S (n=1)", "F603V (n=1)", "S1632Y (n=1)", "X1306_splice (n=1)", "R370H (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; 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not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Multiple Myeloma (Broad, Cancer Cell 2014)", "source_url": "https://www.cbioportal.org/study/summary?id=mm_broad", "source_record_id": "mm_broad", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Multiple Myeloma (Broad, Cancer Cell 2014), 7/205 patients (3.41%).", "Without the 1 hypermutated patients: 6/204 (2.94%).", "Observed in 1 of 1 cohorts; 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not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Multiple Myeloma (Broad, Cancer Cell 2014)", "source_url": "https://www.cbioportal.org/study/summary?id=mm_broad", "source_record_id": "mm_broad", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Multiple Myeloma (Broad, Cancer Cell 2014), 7/205 patients (3.41%).", "Without the 1 hypermutated patients: 7/204 (3.43%).", "Observed in 1 of 1 cohorts; 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not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Multiple Myeloma (Broad, Cancer Cell 2014)", "source_url": "https://www.cbioportal.org/study/summary?id=mm_broad", "source_record_id": "mm_broad", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Multiple Myeloma (Broad, Cancer Cell 2014), 7/205 patients (3.41%).", "Without the 1 hypermutated patients: 7/204 (3.43%).", "Observed in 1 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "mm_broad", "cohort_name": "Multiple Myeloma (Broad, Cancer Cell 2014)", "altered": 7, "tested": 205, "frequency": 3.41, "frequency_excl_hypermutated": 3.43, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "205/211", "coverage_note": null, "source_id": "mm_broad", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 11.37, "width": 1.0, "reference": 11.37, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 7, "tested": 205, "frequency": 3.41, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "COL21A1", "alteration_types": ["SNV / small indel"], "altered": 7, "tested": 205, "frequency": 3.41, "cohort_count": 1, "frequency_range": {"min": 3.41, "max": 3.41}, "major_variants": ["V259I (n=1)", "L16F (n=1)", "V282L (n=1)", "G840A (n=1)", "L809R (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Multiple Myeloma (Broad, Cancer Cell 2014)", "source_url": "https://www.cbioportal.org/study/summary?id=mm_broad", "source_record_id": "mm_broad", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Multiple Myeloma (Broad, Cancer Cell 2014), 7/205 patients (3.41%).", "Without the 1 hypermutated patients: 7/204 (3.43%).", "Observed in 1 of 1 cohorts; 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not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Multiple Myeloma (Broad, Cancer Cell 2014)", "source_url": "https://www.cbioportal.org/study/summary?id=mm_broad", "source_record_id": "mm_broad", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Multiple Myeloma (Broad, Cancer Cell 2014), 7/205 patients (3.41%).", "Without the 1 hypermutated patients: 7/204 (3.43%).", "Observed in 1 of 1 cohorts; 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not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Multiple Myeloma (Broad, Cancer Cell 2014)", "source_url": "https://www.cbioportal.org/study/summary?id=mm_broad", "source_record_id": "mm_broad", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Multiple Myeloma (Broad, Cancer Cell 2014), 7/205 patients (3.41%).", "Without the 1 hypermutated patients: 6/204 (2.94%).", "Observed in 1 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "mm_broad", "cohort_name": "Multiple Myeloma (Broad, Cancer Cell 2014)", "altered": 7, "tested": 205, "frequency": 3.41, "frequency_excl_hypermutated": 2.94, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "205/211", "coverage_note": null, "source_id": "mm_broad", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 11.37, "width": 1.0, "reference": 11.37, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 7, "tested": 205, "frequency": 3.41, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "VCAN", "alteration_types": ["SNV / small indel"], "altered": 6, "tested": 205, "frequency": 2.93, "cohort_count": 1, "frequency_range": {"min": 2.93, "max": 2.93}, "major_variants": ["Q2317* (n=1)", "T1142R (n=1)", "R1125H (n=1)", "E1757K (n=1)", "P2062L (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Multiple Myeloma (Broad, Cancer Cell 2014)", "source_url": "https://www.cbioportal.org/study/summary?id=mm_broad", "source_record_id": "mm_broad", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Multiple Myeloma (Broad, Cancer Cell 2014), 6/205 patients (2.93%).", "Without the 1 hypermutated patients: 6/204 (2.94%).", "Observed in 1 of 1 cohorts; 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not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Multiple Myeloma (Broad, Cancer Cell 2014)", "source_url": "https://www.cbioportal.org/study/summary?id=mm_broad", "source_record_id": "mm_broad", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Multiple Myeloma (Broad, Cancer Cell 2014), 5/205 patients (2.44%).", "Without the 1 hypermutated patients: 5/204 (2.45%).", "Observed in 1 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "mm_broad", "cohort_name": "Multiple Myeloma (Broad, Cancer Cell 2014)", "altered": 5, "tested": 205, "frequency": 2.44, "frequency_excl_hypermutated": 2.45, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "205/211", "coverage_note": null, "source_id": "mm_broad", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 8.13, "width": 1.0, "reference": 8.13, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 5, "tested": 205, "frequency": 2.44, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "SPATA31E1", "alteration_types": ["SNV / small indel"], "altered": 5, "tested": 205, "frequency": 2.44, "cohort_count": 1, "frequency_range": {"min": 2.44, "max": 2.44}, "major_variants": ["G1362C (n=1)", "N137D (n=1)", "E1341K (n=1)", "R1218S (n=1)", "P797L (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Multiple Myeloma (Broad, Cancer Cell 2014)", "source_url": "https://www.cbioportal.org/study/summary?id=mm_broad", "source_record_id": "mm_broad", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Multiple Myeloma (Broad, Cancer Cell 2014), 5/205 patients (2.44%).", "Without the 1 hypermutated patients: 4/204 (1.96%).", "Observed in 1 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "mm_broad", "cohort_name": "Multiple Myeloma (Broad, Cancer Cell 2014)", "altered": 5, "tested": 205, "frequency": 2.44, "frequency_excl_hypermutated": 1.96, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "205/211", "coverage_note": null, "source_id": "mm_broad", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 8.13, "width": 1.0, "reference": 8.13, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 5, "tested": 205, "frequency": 2.44, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "SP140", "alteration_types": ["SNV / small indel"], "altered": 5, "tested": 205, "frequency": 2.44, "cohort_count": 1, "frequency_range": {"min": 2.44, "max": 2.44}, "major_variants": ["S474T (n=1)", "F712L (n=1)", "Q4* (n=1)", "S196Y (n=1)", "X500_splice (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Multiple Myeloma (Broad, Cancer Cell 2014)", "source_url": "https://www.cbioportal.org/study/summary?id=mm_broad", "source_record_id": "mm_broad", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Multiple Myeloma (Broad, Cancer Cell 2014), 5/205 patients (2.44%).", "Without the 1 hypermutated patients: 5/204 (2.45%).", "Observed in 1 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "mm_broad", "cohort_name": "Multiple Myeloma (Broad, Cancer Cell 2014)", "altered": 5, "tested": 205, "frequency": 2.44, "frequency_excl_hypermutated": 2.45, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "205/211", "coverage_note": null, "source_id": "mm_broad", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 8.13, "width": 1.0, "reference": 8.13, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 5, "tested": 205, "frequency": 2.44, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "SCN10A", "alteration_types": ["SNV / small indel"], "altered": 5, "tested": 205, "frequency": 2.44, "cohort_count": 1, "frequency_range": {"min": 2.44, "max": 2.44}, "major_variants": ["R1142H (n=2)", "C144F (n=1)", "V196I (n=1)", "S970I (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Multiple Myeloma (Broad, Cancer Cell 2014)", "source_url": "https://www.cbioportal.org/study/summary?id=mm_broad", "source_record_id": "mm_broad", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Multiple Myeloma (Broad, Cancer Cell 2014), 5/205 patients (2.44%).", "Without the 1 hypermutated patients: 5/204 (2.45%).", "Observed in 1 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "mm_broad", "cohort_name": "Multiple Myeloma (Broad, Cancer Cell 2014)", "altered": 5, "tested": 205, "frequency": 2.44, "frequency_excl_hypermutated": 2.45, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "205/211", "coverage_note": null, "source_id": "mm_broad", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 8.13, "width": 1.0, "reference": 8.13, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 5, "tested": 205, "frequency": 2.44, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "RPRD1B", "alteration_types": ["SNV / small indel"], "altered": 5, "tested": 205, "frequency": 2.44, "cohort_count": 1, "frequency_range": {"min": 2.44, "max": 2.44}, "major_variants": ["L236F (n=1)", "A233V (n=1)", "L276R (n=1)", "Y240C (n=1)", "K272R (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Multiple Myeloma (Broad, Cancer Cell 2014)", "source_url": "https://www.cbioportal.org/study/summary?id=mm_broad", "source_record_id": "mm_broad", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Multiple Myeloma (Broad, Cancer Cell 2014), 5/205 patients (2.44%).", "Without the 1 hypermutated patients: 5/204 (2.45%).", "Observed in 1 of 1 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "mm_broad", "cohort_name": "Multiple Myeloma (Broad, Cancer Cell 2014)", "altered": 5, "tested": 205, "frequency": 2.44, "frequency_excl_hypermutated": 2.45, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "205/211", "coverage_note": null, "source_id": "mm_broad", "is_reference": true}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 8.13, "width": 1.0, "reference": 8.13, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 5, "tested": 205, "frequency": 2.44, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}], "variants": [], "genomic_events": [], "modality_summary": [{"modality": "SNV / small indel", "available_cohorts": 1, "total_cohorts": 1}, {"modality": "Copy number (discrete)", "available_cohorts": 0, "total_cohorts": 1}, {"modality": "Structural variant (present, not read)", "available_cohorts": 0, "total_cohorts": 1}], "chromosome_summary": [], "cohorts": [{"name": "Multiple Myeloma (Broad, Cancer Cell 2014)", "source": "cBioPortal", "accession": "mm_broad", "patients": {"value": 205, "status": "observed", "unit": "patients"}, "samples": {"value": 205, "status": "observed", "unit": "samples"}, "disease_subtype": "Multiple Myeloma (Broad, Cancer Cell 2014)", "assay_type": "exome or genome", "sequencing_method": "WES (205)", "genome_build": "hg19", "alteration_types_available": ["SNV", "small indel"], "genes_assayed": "all coding genes", "primary_or_metastatic": null, "age_group": null, "retrieved_at": "2026-09-18", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "source_record_id": "mm_broad", "is_demo": false, "assay_coverage": {"patients_with_calls": 205, "patients_in_roster": 205, "frequencies_computed": true, "samples_sequenced": 205, "samples_in_study": 211, "hypermutated_patients": 1, "median_mutations_per_sample": 34, "reason": null}}], "sources": [{"source_name": "cBioPortal · Multiple Myeloma (Broad, Cancer Cell 2014)", "source_url": "https://www.cbioportal.org/study/summary?id=mm_broad", "source_record_id": "mm_broad", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "limitations": ["A cBioPortal public-API snapshot retrieved 2026-09-18; the page does not refresh source data at request time.", "Counts are patients with at least one non-silent call in the study's sequenced sample list; silent, intronic and UTR calls are excluded.", "For targeted-panel cohorts each gene divides by the patients whose panel carried it; a gene absent from the panel is shown as not assayed, not as zero.", "Copy-number rows use discrete calls (2 = high-level amplification, −2 = deep deletion) against the cohort's copy-number sample list, which is a different roster from the sequenced one.", "Cohorts are not pooled. Cross-study patient overlap has not been checked and no disease-wide frequency is reported.", "Structural variants and fusions are not read in this snapshot even where the study carries a profile; germline variants, mutational signatures, TMB and MSI are not reported.", "The gene set is the briefing's curated targets plus the reference cohort's most frequently mutated genes; it is not genome-wide."], "answer_block": ["In Multiple Myeloma (Broad, Cancer Cell 2014) (205 sequenced patients, exome or genome), the most frequently altered of the 50 genes shown are KRAS 21.95%, NRAS 18.05%, DIS3 9.27%, TP53 7.32%, TENT5C 7.32%. Each figure divides by the patients on whom that gene could be called.", "1 of 205 patients are hypermutated (more than 340 non-silent mutations, ten times the cohort median of 34); every gene's frequency without them is beside the headline.", "Of the briefing's 14 curated targets, 9 are altered in under 2% of this cohort (TNFRSF17, GPRC5D, FCRL5, CD38, SLAMF7, CRBN, PSMB5, XPO1, MYC): targets by expression, dependency or drug label, not by mutation. Frequency is not targetability, in either direction.", "1 cohorts are shown and none are pooled; overlap between them has not been checked and there is no disease-wide percentage."], "key_findings": [{"finding": "KRAS is mutated in 45 of 205 patients in Multiple Myeloma (Broad, Cancer Cell 2014).", "numerator": 45, "denominator": 205, "frequency": 21.95, "cohorts": 1, "evidence_confidence": "moderate", "source": "mm_broad", "retrieved_at": "2026-09-18"}, {"finding": "NRAS is mutated in 37 of 205 patients in Multiple Myeloma (Broad, Cancer Cell 2014).", "numerator": 37, "denominator": 205, "frequency": 18.05, "cohorts": 1, "evidence_confidence": "moderate", "source": "mm_broad", "retrieved_at": "2026-09-18"}, {"finding": "DIS3 is mutated in 19 of 205 patients in Multiple Myeloma (Broad, Cancer Cell 2014).", "numerator": 19, "denominator": 205, "frequency": 9.27, "cohorts": 1, "evidence_confidence": "moderate", "source": "mm_broad", "retrieved_at": "2026-09-18"}], "research_gaps": [{"kind": "Structural variants", "text": "Read the structural-variant profiles the studies carry; fusions are the defining event in several of these diseases."}, {"kind": "Context", "text": "Stage, subtype, age and treatment line are not attached to any count; the cohorts differ on all four."}, {"kind": "Interpretation", "text": "Activating versus inactivating, actionable versus not, and evidence level are not inferred here; the briefing's target table carries the drug and trial facts."}], "observations": [], "data_status": "PUBLIC SOURCE SNAPSHOT", "is_demo": false, "reference_cohort": "mm_broad", "region_events": [], "matrix": [{"label": "TNFRSF17", "kind": "SNV / small indel", "gene": "TNFRSF17", "cells": [{"cohort": "mm_broad", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 205, "note": null}]}, {"label": "GPRC5D", "kind": "SNV / small indel", "gene": "GPRC5D", "cells": [{"cohort": "mm_broad", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 205, "note": null}]}, {"label": "FCRL5", "kind": "SNV / small indel", "gene": "FCRL5", "cells": [{"cohort": "mm_broad", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 205, "note": null}]}, {"label": "CD38", "kind": "SNV / small indel", "gene": "CD38", "cells": [{"cohort": "mm_broad", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 205, "note": null}]}, {"label": "SLAMF7", "kind": "SNV / small indel", "gene": "SLAMF7", "cells": [{"cohort": "mm_broad", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 205, "note": null}]}, {"label": "CRBN", "kind": "SNV / small indel", "gene": "CRBN", "cells": [{"cohort": "mm_broad", "status": "observed", "frequency": 0.49, "altered": 1, "tested": 205, "note": null}]}, {"label": "PSMB5", "kind": "SNV / small indel", "gene": "PSMB5", "cells": [{"cohort": "mm_broad", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 205, "note": null}]}, {"label": "XPO1", "kind": "SNV / small indel", "gene": "XPO1", "cells": [{"cohort": "mm_broad", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 205, "note": null}]}, {"label": "KRAS", "kind": "SNV / small indel", "gene": "KRAS", "cells": [{"cohort": "mm_broad", "status": "observed", "frequency": 21.95, "altered": 45, "tested": 205, "note": null}]}, {"label": "NRAS", "kind": "SNV / small indel", "gene": "NRAS", "cells": [{"cohort": "mm_broad", "status": "observed", "frequency": 18.05, "altered": 37, "tested": 205, "note": null}]}, {"label": "TP53", "kind": "SNV / small indel", "gene": "TP53", "cells": [{"cohort": "mm_broad", "status": "observed", "frequency": 7.32, "altered": 15, "tested": 205, "note": null}]}, {"label": "NSD2", "kind": "SNV / small indel", "gene": "NSD2", "cells": [{"cohort": "mm_broad", "status": "observed", "frequency": 2.44, "altered": 5, "tested": 205, "note": null}]}, {"label": "CCND1", "kind": "SNV / small indel", "gene": "CCND1", "cells": [{"cohort": "mm_broad", "status": "observed", "frequency": 3.41, "altered": 7, "tested": 205, "note": null}]}, {"label": "MYC", "kind": "SNV / small indel", "gene": "MYC", "cells": [{"cohort": "mm_broad", "status": "observed", "frequency": 0.98, "altered": 2, "tested": 205, "note": null}]}, {"label": "DIS3", "kind": "SNV / small indel", "gene": "DIS3", "cells": [{"cohort": "mm_broad", "status": "observed", "frequency": 9.27, "altered": 19, "tested": 205, "note": null}]}, {"label": "TENT5C", "kind": "SNV / small indel", "gene": "TENT5C", "cells": [{"cohort": "mm_broad", "status": "observed", "frequency": 7.32, "altered": 15, "tested": 205, "note": null}]}, {"label": "BRAF", "kind": "SNV / small indel", "gene": "BRAF", "cells": [{"cohort": "mm_broad", "status": "observed", "frequency": 6.34, "altered": 13, "tested": 205, "note": null}]}, {"label": "TRIO", "kind": "SNV / small indel", "gene": "TRIO", "cells": [{"cohort": "mm_broad", "status": "observed", "frequency": 4.39, "altered": 9, "tested": 205, "note": null}]}, {"label": "SVIL", "kind": "SNV / small indel", "gene": "SVIL", "cells": [{"cohort": "mm_broad", "status": "observed", "frequency": 3.9, "altered": 8, "tested": 205, "note": null}]}, {"label": "KALRN", "kind": "SNV / small indel", "gene": "KALRN", "cells": [{"cohort": "mm_broad", "status": "observed", "frequency": 3.9, "altered": 8, "tested": 205, "note": null}]}, {"label": "GRIA2", "kind": "SNV / small indel", "gene": "GRIA2", "cells": [{"cohort": "mm_broad", "status": "observed", "frequency": 3.9, "altered": 8, "tested": 205, "note": null}]}, {"label": "TRAF3", "kind": "SNV / small indel", "gene": "TRAF3", "cells": [{"cohort": "mm_broad", "status": "observed", "frequency": 3.41, "altered": 7, "tested": 205, "note": null}]}, {"label": "SI", "kind": "SNV / small indel", "gene": "SI", "cells": [{"cohort": "mm_broad", "status": "observed", "frequency": 3.41, "altered": 7, "tested": 205, "note": null}]}, {"label": "EGR1", "kind": "SNV / small indel", "gene": "EGR1", "cells": [{"cohort": "mm_broad", "status": "observed", "frequency": 3.41, "altered": 7, "tested": 205, "note": null}]}, {"label": "COL21A1", "kind": "SNV / small indel", "gene": "COL21A1", "cells": [{"cohort": "mm_broad", "status": "observed", "frequency": 3.41, "altered": 7, "tested": 205, "note": null}]}, {"label": "CHD3", "kind": "SNV / small indel", "gene": "CHD3", "cells": [{"cohort": "mm_broad", "status": "observed", "frequency": 3.41, "altered": 7, "tested": 205, "note": null}]}, {"label": "ADAMTS9", "kind": "SNV / small indel", "gene": "ADAMTS9", "cells": [{"cohort": "mm_broad", "status": "observed", "frequency": 3.41, "altered": 7, "tested": 205, "note": null}]}, {"label": "VCAN", "kind": "SNV / small indel", "gene": "VCAN", "cells": [{"cohort": "mm_broad", "status": "observed", "frequency": 2.93, "altered": 6, "tested": 205, "note": null}]}, {"label": "TRIP12", "kind": "SNV / small indel", "gene": "TRIP12", "cells": [{"cohort": "mm_broad", "status": "observed", "frequency": 2.93, "altered": 6, 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