{"disease": {"name": "Ovarian cancer", "mondo_id": null, "ncit_id": null, "umls_id": null, "oncotree_code": "hgsoc"}, "updated_at": "2026-09-18", "genome_builds": ["hg19", "hg38"], "cohort_count": 2, "cohort_count_status": "observed", "cohort_count_unit": "cohorts", "evaluable_patients": null, "evaluable_patients_status": "unknown", "evaluable_patients_unit": "patients", "alteration_types": ["SNV", "small indel", "amplification", "deep deletion"], "genes": [{"gene": "TP53", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 371, "tested": 523, "frequency": 70.94, "cohort_count": 2, "frequency_range": {"min": 70.94, "max": 77.89}, "major_variants": ["R175H (n=15)", "R248Q (n=10)", "X187_splice (n=10)", "R273H (n=9)", "R248W (n=9)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=ov_tcga_pan_can_atlas_2018", "source_record_id": "ov_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Ovarian Cancer (CPTAC GDC, 2025)", "source_url": "https://www.cbioportal.org/study/summary?id=ovary_cptac_gdc", "source_record_id": "ovary_cptac_gdc", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg38", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas), 371/523 patients (70.94%).", "Without the 3 hypermutated patients: 370/520 (71.15%).", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "ov_tcga_pan_can_atlas_2018", "cohort_name": "Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "altered": 371, "tested": 523, "frequency": 70.94, "frequency_excl_hypermutated": 71.15, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "523/585", "coverage_note": null, "source_id": "ov_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "ovary_cptac_gdc", "cohort_name": "Ovarian Cancer (CPTAC GDC, 2025)", "altered": 74, "tested": 95, "frequency": 77.89, "frequency_excl_hypermutated": 77.66, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "95/112", "coverage_note": null, "source_id": "ovary_cptac_gdc", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 100.0, "width": 1.0, "reference": 100.0, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 371, "tested": 523, "frequency": 70.94, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "BRCA1", "alteration_types": ["SNV / small indel", "deep deletion"], "altered": 18, "tested": 523, "frequency": 3.44, "cohort_count": 2, "frequency_range": {"min": 3.44, "max": 6.32}, "major_variants": ["I1108* (n=1)", "Q1538* (n=1)", "W1718* (n=1)", "N1265Kfs*4 (n=1)", "Y655Vfs*18 (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=ov_tcga_pan_can_atlas_2018", "source_record_id": "ov_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Ovarian Cancer (CPTAC GDC, 2025)", "source_url": "https://www.cbioportal.org/study/summary?id=ovary_cptac_gdc", "source_record_id": "ovary_cptac_gdc", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg38", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas), 18/523 patients (3.44%).", "Without the 3 hypermutated patients: 18/520 (3.46%).", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "ov_tcga_pan_can_atlas_2018", "cohort_name": "Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "altered": 18, "tested": 523, "frequency": 3.44, "frequency_excl_hypermutated": 3.46, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "523/585", "coverage_note": null, "source_id": "ov_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "ovary_cptac_gdc", "cohort_name": "Ovarian Cancer (CPTAC GDC, 2025)", "altered": 6, "tested": 95, "frequency": 6.32, "frequency_excl_hypermutated": 5.32, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "95/112", "coverage_note": null, "source_id": "ovary_cptac_gdc", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 11.47, "width": 9.6, "reference": 11.47, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 18, "tested": 523, "frequency": 3.44, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "BRCA2", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 15, "tested": 523, "frequency": 2.87, "cohort_count": 2, "frequency_range": {"min": 2.87, "max": 3.16}, "major_variants": ["C711* (n=1)", "N1906I (n=1)", "Q1934K (n=1)", "S1882* (n=1)", "K1406Nfs*3 (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=ov_tcga_pan_can_atlas_2018", "source_record_id": "ov_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Ovarian Cancer (CPTAC GDC, 2025)", "source_url": "https://www.cbioportal.org/study/summary?id=ovary_cptac_gdc", "source_record_id": "ovary_cptac_gdc", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg38", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas), 15/523 patients (2.87%).", "Without the 3 hypermutated patients: 13/520 (2.5%).", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "ov_tcga_pan_can_atlas_2018", "cohort_name": "Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "altered": 15, "tested": 523, "frequency": 2.87, "frequency_excl_hypermutated": 2.5, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "523/585", "coverage_note": null, "source_id": "ov_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "ovary_cptac_gdc", "cohort_name": "Ovarian Cancer (CPTAC GDC, 2025)", "altered": 3, "tested": 95, "frequency": 3.16, "frequency_excl_hypermutated": 2.13, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "95/112", "coverage_note": null, "source_id": "ovary_cptac_gdc", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 9.57, "width": 1.0, "reference": 9.57, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 15, "tested": 523, "frequency": 2.87, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "CCNE1", "alteration_types": ["SNV / small indel", "amplification"], "altered": 2, "tested": 523, "frequency": 0.38, "cohort_count": 1, "frequency_range": {"min": 0.0, "max": 0.38}, "major_variants": ["I298V (n=1)", "L161V (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=ov_tcga_pan_can_atlas_2018", "source_record_id": "ov_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Ovarian Cancer (CPTAC GDC, 2025)", "source_url": "https://www.cbioportal.org/study/summary?id=ovary_cptac_gdc", "source_record_id": "ovary_cptac_gdc", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg38", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas), 2/523 patients (0.38%).", "Without the 3 hypermutated patients: 2/520 (0.38%).", "Largest alteration is amplification: 112/572 (19.58%) in the reference cohort's copy-number profile.", "Observed in 1 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "ov_tcga_pan_can_atlas_2018", "cohort_name": "Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "altered": 2, "tested": 523, "frequency": 0.38, "frequency_excl_hypermutated": 0.38, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "523/585", "coverage_note": null, "source_id": "ov_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "ovary_cptac_gdc", "cohort_name": "Ovarian Cancer (CPTAC GDC, 2025)", "altered": 0, "tested": 95, "frequency": 0.0, "frequency_excl_hypermutated": 0.0, "counting_unit": "patients", "status": "not_observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "95/112", "coverage_note": null, "source_id": "ovary_cptac_gdc", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 65.27, "width": 1.0, "reference": 65.27, "scale_max": 30.0}, "headline_alteration": {"kind": "amplification", "altered": 112, "tested": 572, "frequency": 19.58, "is_mutation": false}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "FOLR1", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 3, "tested": 523, "frequency": 0.57, "cohort_count": 1, "frequency_range": {"min": 0.0, "max": 0.57}, "major_variants": ["H43N (n=1)", "E191K (n=1)", "A64T (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=ov_tcga_pan_can_atlas_2018", "source_record_id": "ov_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Ovarian Cancer (CPTAC GDC, 2025)", "source_url": "https://www.cbioportal.org/study/summary?id=ovary_cptac_gdc", "source_record_id": "ovary_cptac_gdc", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg38", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas), 3/523 patients (0.57%).", "Without the 3 hypermutated patients: 2/520 (0.38%).", "Largest alteration is amplification: 27/572 (4.72%) in the reference cohort's copy-number profile.", "Observed in 1 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "ov_tcga_pan_can_atlas_2018", "cohort_name": "Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "altered": 3, "tested": 523, "frequency": 0.57, "frequency_excl_hypermutated": 0.38, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "523/585", "coverage_note": null, "source_id": "ov_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "ovary_cptac_gdc", "cohort_name": "Ovarian Cancer (CPTAC GDC, 2025)", "altered": 0, "tested": 95, "frequency": 0.0, "frequency_excl_hypermutated": 0.0, "counting_unit": "patients", "status": "not_observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "95/112", "coverage_note": null, "source_id": "ovary_cptac_gdc", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 15.73, "width": 1.0, "reference": 15.73, "scale_max": 30.0}, "headline_alteration": {"kind": "amplification", "altered": 27, "tested": 572, "frequency": 4.72, "is_mutation": false}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "MUC16", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 41, "tested": 523, "frequency": 7.84, "cohort_count": 2, "frequency_range": {"min": 7.84, "max": 12.63}, "major_variants": ["P2968H (n=1)", "M10796I (n=1)", "G7334W (n=1)", "L2900F (n=1)", "G10957C (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=ov_tcga_pan_can_atlas_2018", "source_record_id": "ov_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Ovarian Cancer (CPTAC GDC, 2025)", "source_url": "https://www.cbioportal.org/study/summary?id=ovary_cptac_gdc", "source_record_id": "ovary_cptac_gdc", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg38", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas), 41/523 patients (7.84%).", "Without the 3 hypermutated patients: 40/520 (7.69%).", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "ov_tcga_pan_can_atlas_2018", "cohort_name": "Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "altered": 41, "tested": 523, "frequency": 7.84, "frequency_excl_hypermutated": 7.69, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "523/585", "coverage_note": null, "source_id": "ov_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "ovary_cptac_gdc", "cohort_name": "Ovarian Cancer (CPTAC GDC, 2025)", "altered": 12, "tested": 95, "frequency": 12.63, "frequency_excl_hypermutated": 11.7, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "95/112", "coverage_note": null, "source_id": "ovary_cptac_gdc", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 26.13, "width": 15.97, "reference": 26.13, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 41, "tested": 523, "frequency": 7.84, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "MSLN", "alteration_types": ["amplification", "deep deletion"], "altered": 0, "tested": 523, "frequency": 0.0, "cohort_count": 0, "frequency_range": {"min": 0.0, "max": 0.0}, "major_variants": [], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=ov_tcga_pan_can_atlas_2018", "source_record_id": "ov_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Ovarian Cancer (CPTAC GDC, 2025)", "source_url": "https://www.cbioportal.org/study/summary?id=ovary_cptac_gdc", "source_record_id": "ovary_cptac_gdc", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg38", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas), 0/523 patients (0.0%).", "Without the 3 hypermutated patients: 0/520 (0.0%).", "Largest alteration is amplification: 11/572 (1.92%) in the reference cohort's copy-number profile.", "Observed in 0 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "ov_tcga_pan_can_atlas_2018", "cohort_name": "Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "altered": 0, "tested": 523, "frequency": 0.0, "frequency_excl_hypermutated": 0.0, "counting_unit": "patients", "status": "not_observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "523/585", "coverage_note": null, "source_id": "ov_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "ovary_cptac_gdc", "cohort_name": "Ovarian Cancer (CPTAC GDC, 2025)", "altered": 0, "tested": 95, "frequency": 0.0, "frequency_excl_hypermutated": 0.0, "counting_unit": "patients", "status": "not_observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "95/112", "coverage_note": null, "source_id": "ovary_cptac_gdc", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 6.4, "width": 1.0, "reference": 6.4, "scale_max": 30.0}, "headline_alteration": {"kind": "amplification", "altered": 11, "tested": 572, "frequency": 1.92, "is_mutation": false}, "altered_status": "not_observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "not_observed", "frequency_unit": "percent", "cohort_count_status": "not_observed", "cohort_count_unit": "cohorts"}, {"gene": "KRAS", "alteration_types": ["SNV / small indel", "amplification"], "altered": 6, "tested": 523, "frequency": 1.15, "cohort_count": 2, "frequency_range": {"min": 1.15, "max": 2.11}, "major_variants": ["G12V (n=4)", "G12R (n=1)", "Q61L (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=ov_tcga_pan_can_atlas_2018", "source_record_id": "ov_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Ovarian Cancer (CPTAC GDC, 2025)", "source_url": "https://www.cbioportal.org/study/summary?id=ovary_cptac_gdc", "source_record_id": "ovary_cptac_gdc", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg38", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas), 6/523 patients (1.15%).", "Without the 3 hypermutated patients: 6/520 (1.15%).", "Largest alteration is amplification: 54/572 (9.44%) in the reference cohort's copy-number profile.", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "ov_tcga_pan_can_atlas_2018", "cohort_name": "Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "altered": 6, "tested": 523, "frequency": 1.15, "frequency_excl_hypermutated": 1.15, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "523/585", "coverage_note": null, "source_id": "ov_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "ovary_cptac_gdc", "cohort_name": "Ovarian Cancer (CPTAC GDC, 2025)", "altered": 2, "tested": 95, "frequency": 2.11, "frequency_excl_hypermutated": 1.06, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "95/112", "coverage_note": null, "source_id": "ovary_cptac_gdc", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 31.47, "width": 1.0, "reference": 31.47, "scale_max": 30.0}, "headline_alteration": {"kind": "amplification", "altered": 54, "tested": 572, "frequency": 9.44, "is_mutation": false}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "ARID1A", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 4, "tested": 523, "frequency": 0.76, "cohort_count": 2, "frequency_range": {"min": 0.76, "max": 4.21}, "major_variants": ["S664* (n=1)", "Q1708* (n=1)", "W1073Mfs*32 (n=1)", "E1766* (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=ov_tcga_pan_can_atlas_2018", "source_record_id": "ov_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Ovarian Cancer (CPTAC GDC, 2025)", "source_url": "https://www.cbioportal.org/study/summary?id=ovary_cptac_gdc", "source_record_id": "ovary_cptac_gdc", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg38", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas), 4/523 patients (0.76%).", "Without the 3 hypermutated patients: 4/520 (0.77%).", "Largest alteration is deep deletion: 5/572 (0.87%) in the reference cohort's copy-number profile.", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "ov_tcga_pan_can_atlas_2018", "cohort_name": "Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "altered": 4, "tested": 523, "frequency": 0.76, "frequency_excl_hypermutated": 0.77, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "523/585", "coverage_note": null, "source_id": "ov_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "ovary_cptac_gdc", "cohort_name": "Ovarian Cancer (CPTAC GDC, 2025)", "altered": 4, "tested": 95, "frequency": 4.21, "frequency_excl_hypermutated": 3.19, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "95/112", "coverage_note": null, "source_id": "ovary_cptac_gdc", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 2.9, "width": 1.0, "reference": 2.9, "scale_max": 30.0}, "headline_alteration": {"kind": "deep deletion", "altered": 5, "tested": 572, "frequency": 0.87, "is_mutation": false}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "PIK3CA", "alteration_types": ["SNV / small indel", "amplification"], "altered": 8, "tested": 523, "frequency": 1.53, "cohort_count": 2, "frequency_range": {"min": 1.53, "max": 3.16}, "major_variants": ["H1047R (n=2)", "E545K (n=1)", "E545A (n=1)", "E849K (n=1)", "E545G (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=ov_tcga_pan_can_atlas_2018", "source_record_id": "ov_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Ovarian Cancer (CPTAC GDC, 2025)", "source_url": "https://www.cbioportal.org/study/summary?id=ovary_cptac_gdc", "source_record_id": "ovary_cptac_gdc", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg38", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas), 8/523 patients (1.53%).", "Without the 3 hypermutated patients: 7/520 (1.35%).", "Largest alteration is amplification: 116/572 (20.28%) in the reference cohort's copy-number profile.", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "ov_tcga_pan_can_atlas_2018", "cohort_name": "Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "altered": 8, "tested": 523, "frequency": 1.53, "frequency_excl_hypermutated": 1.35, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "523/585", "coverage_note": null, "source_id": "ov_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "ovary_cptac_gdc", "cohort_name": "Ovarian Cancer (CPTAC GDC, 2025)", "altered": 3, "tested": 95, "frequency": 3.16, "frequency_excl_hypermutated": 2.13, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "95/112", "coverage_note": null, "source_id": "ovary_cptac_gdc", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 67.6, "width": 1.0, "reference": 67.6, "scale_max": 30.0}, "headline_alteration": {"kind": "amplification", "altered": 116, "tested": 572, "frequency": 20.28, "is_mutation": false}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "PTEN", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 7, "tested": 523, "frequency": 1.34, "cohort_count": 2, "frequency_range": {"min": 1.34, "max": 3.16}, "major_variants": ["Y188D (n=1)", "V175L (n=1)", "R233Dfs*23 (n=1)", "X212_splice (n=1)", "Y138S (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=ov_tcga_pan_can_atlas_2018", "source_record_id": "ov_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Ovarian Cancer (CPTAC GDC, 2025)", "source_url": "https://www.cbioportal.org/study/summary?id=ovary_cptac_gdc", "source_record_id": "ovary_cptac_gdc", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg38", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas), 7/523 patients (1.34%).", "Without the 3 hypermutated patients: 7/520 (1.35%).", "Largest alteration is deep deletion: 26/572 (4.55%) in the reference cohort's copy-number profile.", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "ov_tcga_pan_can_atlas_2018", "cohort_name": "Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "altered": 7, "tested": 523, "frequency": 1.34, "frequency_excl_hypermutated": 1.35, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "523/585", "coverage_note": null, "source_id": "ov_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "ovary_cptac_gdc", "cohort_name": "Ovarian Cancer (CPTAC GDC, 2025)", "altered": 3, "tested": 95, "frequency": 3.16, "frequency_excl_hypermutated": 2.13, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "95/112", "coverage_note": null, "source_id": "ovary_cptac_gdc", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 15.17, "width": 1.0, "reference": 15.17, "scale_max": 30.0}, "headline_alteration": {"kind": "deep deletion", "altered": 26, "tested": 572, "frequency": 4.55, "is_mutation": false}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "NF1", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 30, "tested": 523, "frequency": 5.74, "cohort_count": 2, "frequency_range": {"min": 3.16, "max": 5.74}, "major_variants": ["K1444E (n=1)", "Q112* (n=1)", "Y80Lfs*27 (n=1)", "E1583* (n=1)", "G2816A (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=ov_tcga_pan_can_atlas_2018", "source_record_id": "ov_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Ovarian Cancer (CPTAC GDC, 2025)", "source_url": "https://www.cbioportal.org/study/summary?id=ovary_cptac_gdc", "source_record_id": "ovary_cptac_gdc", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg38", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas), 30/523 patients (5.74%).", "Without the 3 hypermutated patients: 30/520 (5.77%).", "Largest alteration is deep deletion: 36/572 (6.29%) in the reference cohort's copy-number profile.", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "ov_tcga_pan_can_atlas_2018", "cohort_name": "Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "altered": 30, "tested": 523, "frequency": 5.74, "frequency_excl_hypermutated": 5.77, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "523/585", "coverage_note": null, "source_id": "ov_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "ovary_cptac_gdc", "cohort_name": "Ovarian Cancer (CPTAC GDC, 2025)", "altered": 3, "tested": 95, "frequency": 3.16, "frequency_excl_hypermutated": 2.13, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "95/112", "coverage_note": null, "source_id": "ovary_cptac_gdc", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 20.97, "width": 1.0, "reference": 20.97, "scale_max": 30.0}, "headline_alteration": {"kind": "deep deletion", "altered": 36, "tested": 572, "frequency": 6.29, "is_mutation": false}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "KMT2C", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 24, "tested": 523, "frequency": 4.59, "cohort_count": 2, "frequency_range": {"min": 4.59, "max": 5.26}, "major_variants": ["R1861L (n=1)", "Y366S (n=1)", "H2604N (n=1)", "N3347S (n=1)", "K4229M (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=ov_tcga_pan_can_atlas_2018", "source_record_id": "ov_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Ovarian Cancer (CPTAC GDC, 2025)", "source_url": "https://www.cbioportal.org/study/summary?id=ovary_cptac_gdc", "source_record_id": "ovary_cptac_gdc", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg38", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas), 24/523 patients (4.59%).", "Without the 3 hypermutated patients: 23/520 (4.42%).", "Largest alteration is amplification: 42/572 (7.34%) in the reference cohort's copy-number profile.", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "ov_tcga_pan_can_atlas_2018", "cohort_name": "Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "altered": 24, "tested": 523, "frequency": 4.59, "frequency_excl_hypermutated": 4.42, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "523/585", "coverage_note": null, "source_id": "ov_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "ovary_cptac_gdc", "cohort_name": "Ovarian Cancer (CPTAC GDC, 2025)", "altered": 5, "tested": 95, "frequency": 5.26, "frequency_excl_hypermutated": 4.26, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "95/112", "coverage_note": null, "source_id": "ovary_cptac_gdc", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 24.47, "width": 1.0, "reference": 24.47, "scale_max": 30.0}, "headline_alteration": {"kind": "amplification", "altered": 42, "tested": 572, "frequency": 7.34, "is_mutation": false}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "SI", "alteration_types": ["SNV / small indel", "amplification"], "altered": 22, "tested": 523, "frequency": 4.21, "cohort_count": 2, "frequency_range": {"min": 3.16, "max": 4.21}, "major_variants": ["P1202T (n=1)", "K206N (n=1)", "E1730D (n=1)", "T1017N (n=1)", "I1034F (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=ov_tcga_pan_can_atlas_2018", "source_record_id": "ov_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Ovarian Cancer (CPTAC GDC, 2025)", "source_url": "https://www.cbioportal.org/study/summary?id=ovary_cptac_gdc", "source_record_id": "ovary_cptac_gdc", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg38", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas), 22/523 patients (4.21%).", "Without the 3 hypermutated patients: 22/520 (4.23%).", "Largest alteration is amplification: 90/572 (15.73%) in the reference cohort's copy-number profile.", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "ov_tcga_pan_can_atlas_2018", "cohort_name": "Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "altered": 22, "tested": 523, "frequency": 4.21, "frequency_excl_hypermutated": 4.23, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "523/585", "coverage_note": null, "source_id": "ov_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "ovary_cptac_gdc", "cohort_name": "Ovarian Cancer (CPTAC GDC, 2025)", "altered": 3, "tested": 95, "frequency": 3.16, "frequency_excl_hypermutated": 2.13, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "95/112", "coverage_note": null, "source_id": "ovary_cptac_gdc", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 52.43, "width": 1.0, "reference": 52.43, "scale_max": 30.0}, "headline_alteration": {"kind": "amplification", "altered": 90, "tested": 572, "frequency": 15.73, "is_mutation": false}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "MDN1", "alteration_types": ["SNV / small indel", "amplification"], "altered": 21, "tested": 523, "frequency": 4.02, "cohort_count": 2, "frequency_range": {"min": 3.16, "max": 4.02}, "major_variants": ["R3561M (n=1)", "V4613D (n=1)", "K2999M (n=1)", "S5086F (n=1)", "D5192H (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=ov_tcga_pan_can_atlas_2018", "source_record_id": "ov_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Ovarian Cancer (CPTAC GDC, 2025)", "source_url": "https://www.cbioportal.org/study/summary?id=ovary_cptac_gdc", "source_record_id": "ovary_cptac_gdc", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg38", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas), 21/523 patients (4.02%).", "Without the 3 hypermutated patients: 20/520 (3.85%).", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "ov_tcga_pan_can_atlas_2018", "cohort_name": "Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "altered": 21, "tested": 523, "frequency": 4.02, "frequency_excl_hypermutated": 3.85, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "523/585", "coverage_note": null, "source_id": "ov_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "ovary_cptac_gdc", "cohort_name": "Ovarian Cancer (CPTAC GDC, 2025)", "altered": 3, "tested": 95, "frequency": 3.16, "frequency_excl_hypermutated": 2.13, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "95/112", "coverage_note": null, "source_id": "ovary_cptac_gdc", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 10.53, "width": 2.87, "reference": 13.4, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 21, "tested": 523, "frequency": 4.02, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "FCGBP", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 21, "tested": 523, "frequency": 4.02, "cohort_count": 2, "frequency_range": {"min": 4.02, "max": 5.26}, "major_variants": ["V5330M (n=1)", "C2750F (n=1)", "G321D (n=1)", "E4382V (n=1)", "R5092H (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=ov_tcga_pan_can_atlas_2018", "source_record_id": "ov_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Ovarian Cancer (CPTAC GDC, 2025)", "source_url": "https://www.cbioportal.org/study/summary?id=ovary_cptac_gdc", "source_record_id": "ovary_cptac_gdc", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg38", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas), 21/523 patients (4.02%).", "Without the 3 hypermutated patients: 21/520 (4.04%).", "Largest alteration is amplification: 50/572 (8.74%) in the reference cohort's copy-number profile.", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "ov_tcga_pan_can_atlas_2018", "cohort_name": "Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "altered": 21, "tested": 523, "frequency": 4.02, "frequency_excl_hypermutated": 4.04, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "523/585", "coverage_note": null, "source_id": "ov_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "ovary_cptac_gdc", "cohort_name": "Ovarian Cancer (CPTAC GDC, 2025)", "altered": 5, "tested": 95, "frequency": 5.26, "frequency_excl_hypermutated": 4.26, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "95/112", "coverage_note": null, "source_id": "ovary_cptac_gdc", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 29.13, "width": 1.0, "reference": 29.13, "scale_max": 30.0}, "headline_alteration": {"kind": "amplification", "altered": 50, "tested": 572, "frequency": 8.74, "is_mutation": false}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "COL6A3", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 21, "tested": 523, "frequency": 4.02, "cohort_count": 2, "frequency_range": {"min": 2.11, "max": 4.02}, "major_variants": ["Q348L (n=1)", "Q788H (n=1)", "G35C (n=1)", "X1946_splice (n=1)", "K1861M (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=ov_tcga_pan_can_atlas_2018", "source_record_id": "ov_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Ovarian Cancer (CPTAC GDC, 2025)", "source_url": "https://www.cbioportal.org/study/summary?id=ovary_cptac_gdc", "source_record_id": "ovary_cptac_gdc", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg38", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas), 21/523 patients (4.02%).", "Without the 3 hypermutated patients: 20/520 (3.85%).", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "ov_tcga_pan_can_atlas_2018", "cohort_name": "Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "altered": 21, "tested": 523, "frequency": 4.02, "frequency_excl_hypermutated": 3.85, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "523/585", "coverage_note": null, "source_id": "ov_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "ovary_cptac_gdc", "cohort_name": "Ovarian Cancer (CPTAC GDC, 2025)", "altered": 2, "tested": 95, "frequency": 2.11, "frequency_excl_hypermutated": 1.06, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "95/112", "coverage_note": null, "source_id": "ovary_cptac_gdc", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 7.03, "width": 6.37, "reference": 13.4, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 21, "tested": 523, "frequency": 4.02, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "TG", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 20, "tested": 523, "frequency": 3.82, "cohort_count": 2, "frequency_range": {"min": 3.82, "max": 8.42}, "major_variants": ["V478L (n=1)", "R2336Q (n=1)", "G2341V (n=1)", "Q1299L (n=1)", "S430T (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=ov_tcga_pan_can_atlas_2018", "source_record_id": "ov_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Ovarian Cancer (CPTAC GDC, 2025)", "source_url": "https://www.cbioportal.org/study/summary?id=ovary_cptac_gdc", "source_record_id": "ovary_cptac_gdc", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg38", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas), 20/523 patients (3.82%).", "Without the 3 hypermutated patients: 20/520 (3.85%).", "Largest alteration is amplification: 166/572 (29.02%) in the reference cohort's copy-number profile.", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "ov_tcga_pan_can_atlas_2018", "cohort_name": "Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "altered": 20, "tested": 523, "frequency": 3.82, "frequency_excl_hypermutated": 3.85, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "523/585", "coverage_note": null, "source_id": "ov_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "ovary_cptac_gdc", "cohort_name": "Ovarian Cancer (CPTAC GDC, 2025)", "altered": 8, "tested": 95, "frequency": 8.42, "frequency_excl_hypermutated": 7.45, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "95/112", "coverage_note": null, "source_id": "ovary_cptac_gdc", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 96.73, "width": 1.0, "reference": 96.73, "scale_max": 30.0}, "headline_alteration": {"kind": "amplification", "altered": 166, "tested": 572, "frequency": 29.02, "is_mutation": false}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "MYH4", "alteration_types": ["SNV / small indel", "deep deletion"], "altered": 20, "tested": 523, "frequency": 3.82, "cohort_count": 2, "frequency_range": {"min": 3.82, "max": 4.21}, "major_variants": ["A200S (n=1)", "G686C (n=1)", "G763C (n=1)", "Q1708E (n=1)", "E1709D (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=ov_tcga_pan_can_atlas_2018", "source_record_id": "ov_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Ovarian Cancer (CPTAC GDC, 2025)", "source_url": "https://www.cbioportal.org/study/summary?id=ovary_cptac_gdc", "source_record_id": "ovary_cptac_gdc", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg38", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas), 20/523 patients (3.82%).", "Without the 3 hypermutated patients: 19/520 (3.65%).", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "ov_tcga_pan_can_atlas_2018", "cohort_name": "Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "altered": 20, "tested": 523, "frequency": 3.82, "frequency_excl_hypermutated": 3.65, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "523/585", "coverage_note": null, "source_id": "ov_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "ovary_cptac_gdc", "cohort_name": "Ovarian Cancer (CPTAC GDC, 2025)", "altered": 4, "tested": 95, "frequency": 4.21, "frequency_excl_hypermutated": 3.19, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "95/112", "coverage_note": null, "source_id": "ovary_cptac_gdc", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 12.73, "width": 1.3, "reference": 12.73, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 20, "tested": 523, "frequency": 3.82, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "MYH1", "alteration_types": ["SNV / small indel", "deep deletion"], "altered": 20, "tested": 523, "frequency": 3.82, "cohort_count": 2, "frequency_range": {"min": 3.16, "max": 3.82}, "major_variants": ["K1169T (n=1)", "R1867G (n=1)", "Q911K (n=1)", "T628M (n=1)", "Q806R (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=ov_tcga_pan_can_atlas_2018", "source_record_id": "ov_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", 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"hg38", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas), 20/523 patients (3.82%).", "Without the 3 hypermutated patients: 18/520 (3.46%).", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "ov_tcga_pan_can_atlas_2018", "cohort_name": "Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "altered": 20, "tested": 523, "frequency": 3.82, "frequency_excl_hypermutated": 3.46, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "523/585", "coverage_note": null, "source_id": "ov_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "ovary_cptac_gdc", "cohort_name": "Ovarian Cancer (CPTAC GDC, 2025)", "altered": 2, "tested": 95, "frequency": 2.11, 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"E212Qfs*30 (n=1)", "L1166F (n=1)", "X160_splice (n=1)", "M204Ifs*20 (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=ov_tcga_pan_can_atlas_2018", "source_record_id": "ov_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": 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"ov_tcga_pan_can_atlas_2018", "cohort_name": "Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "altered": 19, "tested": 523, "frequency": 3.63, "frequency_excl_hypermutated": 3.65, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "523/585", "coverage_note": null, "source_id": "ov_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "ovary_cptac_gdc", "cohort_name": "Ovarian Cancer (CPTAC GDC, 2025)", "altered": 1, "tested": 95, "frequency": 1.05, "frequency_excl_hypermutated": 0.0, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "95/112", "coverage_note": null, "source_id": "ovary_cptac_gdc", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 3.5, "width": 8.6, "reference": 12.1, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 19, "tested": 523, "frequency": 3.63, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "SPEN", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 19, "tested": 523, "frequency": 3.63, "cohort_count": 2, "frequency_range": {"min": 3.16, "max": 3.63}, "major_variants": ["A3363S (n=1)", "A995E (n=1)", "R3185L (n=1)", "G2788R (n=1)", "G462E (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; 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"major_variants": ["L3496W (n=1)", "G3454W (n=1)", "G1563C (n=1)", "V712L (n=1)", "V1141Dfs*49 (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=ov_tcga_pan_can_atlas_2018", "source_record_id": "ov_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware 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"altered": 19, "tested": 523, "frequency": 3.63, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "LRRK2", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 19, "tested": 523, "frequency": 3.63, "cohort_count": 2, "frequency_range": {"min": 3.16, "max": 3.63}, "major_variants": ["L829I (n=1)", "P2095A (n=1)", "I952T (n=1)", "P1212Q (n=1)", "Q116K (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", 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non-silent calls, panel-aware denominator", "genome_build": "hg38", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas), 19/523 patients (3.63%).", "Without the 3 hypermutated patients: 17/520 (3.27%).", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "ov_tcga_pan_can_atlas_2018", "cohort_name": "Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "altered": 19, "tested": 523, "frequency": 3.63, "frequency_excl_hypermutated": 3.27, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "523/585", "coverage_note": null, "source_id": "ov_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "ovary_cptac_gdc", "cohort_name": "Ovarian Cancer (CPTAC GDC, 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3.16, "max": 3.63}, "major_variants": ["S363* (n=1)", "X343_splice (n=1)", "S587Y (n=1)", "D121Efs*5 (n=1)", "H835N (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=ov_tcga_pan_can_atlas_2018", "source_record_id": "ov_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Ovarian Cancer (CPTAC GDC, 2025)", "source_url": "https://www.cbioportal.org/study/summary?id=ovary_cptac_gdc", "source_record_id": "ovary_cptac_gdc", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg38", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas), 19/523 patients (3.63%).", "Without the 3 hypermutated patients: 19/520 (3.65%).", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "ov_tcga_pan_can_atlas_2018", "cohort_name": "Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "altered": 19, "tested": 523, "frequency": 3.63, "frequency_excl_hypermutated": 3.65, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "523/585", "coverage_note": null, "source_id": "ov_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "ovary_cptac_gdc", "cohort_name": "Ovarian Cancer (CPTAC GDC, 2025)", "altered": 3, "tested": 95, "frequency": 3.16, "frequency_excl_hypermutated": 2.13, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "95/112", "coverage_note": null, "source_id": "ovary_cptac_gdc", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 10.53, "width": 1.57, "reference": 12.1, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 19, "tested": 523, "frequency": 3.63, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "VPS13B", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 18, "tested": 523, "frequency": 3.44, "cohort_count": 2, "frequency_range": {"min": 3.16, "max": 3.44}, "major_variants": ["H303R (n=1)", "A3720S (n=1)", "A1013S (n=1)", "R1926K (n=1)", "G1637C (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=ov_tcga_pan_can_atlas_2018", "source_record_id": "ov_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Ovarian Cancer (CPTAC GDC, 2025)", "source_url": "https://www.cbioportal.org/study/summary?id=ovary_cptac_gdc", "source_record_id": "ovary_cptac_gdc", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg38", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas), 18/523 patients (3.44%).", "Without the 3 hypermutated patients: 16/520 (3.08%).", "Largest alteration is amplification: 62/572 (10.84%) in the reference cohort's copy-number profile.", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "ov_tcga_pan_can_atlas_2018", "cohort_name": "Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "altered": 18, "tested": 523, "frequency": 3.44, "frequency_excl_hypermutated": 3.08, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "523/585", "coverage_note": null, "source_id": "ov_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "ovary_cptac_gdc", "cohort_name": "Ovarian Cancer (CPTAC GDC, 2025)", "altered": 3, "tested": 95, "frequency": 3.16, "frequency_excl_hypermutated": 2.13, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "95/112", "coverage_note": null, "source_id": "ovary_cptac_gdc", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 36.13, "width": 1.0, "reference": 36.13, "scale_max": 30.0}, "headline_alteration": {"kind": "amplification", "altered": 62, "tested": 572, "frequency": 10.84, "is_mutation": false}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "PEG3", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 18, "tested": 523, "frequency": 3.44, "cohort_count": 2, "frequency_range": {"min": 3.16, "max": 3.44}, "major_variants": ["Q496H (n=1)", "R193W (n=1)", "I472Tfs*107 (n=1)", "R1138Q (n=1)", "E1497D (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=ov_tcga_pan_can_atlas_2018", "source_record_id": "ov_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Ovarian Cancer (CPTAC GDC, 2025)", "source_url": "https://www.cbioportal.org/study/summary?id=ovary_cptac_gdc", "source_record_id": "ovary_cptac_gdc", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg38", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas), 18/523 patients (3.44%).", "Without the 3 hypermutated patients: 18/520 (3.46%).", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "ov_tcga_pan_can_atlas_2018", "cohort_name": "Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "altered": 18, "tested": 523, "frequency": 3.44, "frequency_excl_hypermutated": 3.46, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "523/585", "coverage_note": null, "source_id": "ov_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "ovary_cptac_gdc", "cohort_name": "Ovarian Cancer (CPTAC GDC, 2025)", "altered": 3, "tested": 95, "frequency": 3.16, "frequency_excl_hypermutated": 2.13, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "95/112", "coverage_note": null, "source_id": "ovary_cptac_gdc", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 10.53, "width": 1.0, "reference": 11.47, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 18, "tested": 523, "frequency": 3.44, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "DYNC1H1", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 18, "tested": 523, "frequency": 3.44, "cohort_count": 2, "frequency_range": {"min": 1.05, "max": 3.44}, "major_variants": ["H2637D (n=1)", "T4067S (n=1)", "D1436G (n=1)", "L2889* (n=1)", "E2587K (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=ov_tcga_pan_can_atlas_2018", "source_record_id": "ov_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Ovarian Cancer (CPTAC GDC, 2025)", "source_url": "https://www.cbioportal.org/study/summary?id=ovary_cptac_gdc", "source_record_id": "ovary_cptac_gdc", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg38", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas), 18/523 patients (3.44%).", "Without the 3 hypermutated patients: 18/520 (3.46%).", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "ov_tcga_pan_can_atlas_2018", "cohort_name": "Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "altered": 18, "tested": 523, "frequency": 3.44, "frequency_excl_hypermutated": 3.46, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "523/585", "coverage_note": null, "source_id": "ov_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "ovary_cptac_gdc", "cohort_name": "Ovarian Cancer (CPTAC GDC, 2025)", "altered": 1, "tested": 95, "frequency": 1.05, "frequency_excl_hypermutated": 0.0, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "95/112", "coverage_note": null, "source_id": "ovary_cptac_gdc", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 3.5, "width": 7.97, "reference": 11.47, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 18, "tested": 523, "frequency": 3.44, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "TACC2", "alteration_types": ["SNV / small indel", "amplification"], "altered": 17, "tested": 523, "frequency": 3.25, "cohort_count": 2, "frequency_range": {"min": 2.11, "max": 3.25}, "major_variants": ["A2629V (n=1)", "D2268V (n=1)", "R606H (n=1)", "E1084G (n=1)", "S872F (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=ov_tcga_pan_can_atlas_2018", "source_record_id": "ov_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Ovarian Cancer (CPTAC GDC, 2025)", "source_url": "https://www.cbioportal.org/study/summary?id=ovary_cptac_gdc", "source_record_id": "ovary_cptac_gdc", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg38", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas), 17/523 patients (3.25%).", "Without the 3 hypermutated patients: 17/520 (3.27%).", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "ov_tcga_pan_can_atlas_2018", "cohort_name": "Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "altered": 17, "tested": 523, "frequency": 3.25, "frequency_excl_hypermutated": 3.27, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "523/585", "coverage_note": null, "source_id": "ov_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "ovary_cptac_gdc", "cohort_name": "Ovarian Cancer (CPTAC GDC, 2025)", "altered": 2, "tested": 95, "frequency": 2.11, "frequency_excl_hypermutated": 1.06, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "95/112", "coverage_note": null, "source_id": "ovary_cptac_gdc", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 7.03, "width": 3.8, "reference": 10.83, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 17, "tested": 523, "frequency": 3.25, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "RELN", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 17, "tested": 523, "frequency": 3.25, "cohort_count": 2, "frequency_range": {"min": 1.05, "max": 3.25}, "major_variants": ["X158_splice (n=1)", "D3348E (n=1)", "G1788D (n=1)", "C1347Y (n=1)", "C1347S (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=ov_tcga_pan_can_atlas_2018", "source_record_id": "ov_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Ovarian Cancer (CPTAC GDC, 2025)", "source_url": "https://www.cbioportal.org/study/summary?id=ovary_cptac_gdc", "source_record_id": "ovary_cptac_gdc", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg38", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas), 17/523 patients (3.25%).", "Without the 3 hypermutated patients: 16/520 (3.08%).", "Largest alteration is amplification: 19/572 (3.32%) in the reference cohort's copy-number profile.", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "ov_tcga_pan_can_atlas_2018", "cohort_name": "Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "altered": 17, "tested": 523, "frequency": 3.25, "frequency_excl_hypermutated": 3.08, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "523/585", "coverage_note": null, "source_id": "ov_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "ovary_cptac_gdc", "cohort_name": "Ovarian Cancer (CPTAC GDC, 2025)", "altered": 1, "tested": 95, "frequency": 1.05, "frequency_excl_hypermutated": 1.06, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "95/112", "coverage_note": null, "source_id": "ovary_cptac_gdc", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 11.07, "width": 1.0, "reference": 11.07, "scale_max": 30.0}, "headline_alteration": {"kind": "amplification", "altered": 19, "tested": 572, "frequency": 3.32, "is_mutation": false}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "PTPRZ1", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 17, "tested": 523, "frequency": 3.25, "cohort_count": 2, "frequency_range": {"min": 2.11, "max": 3.25}, "major_variants": ["D2178N (n=1)", "D866Y (n=1)", "G1739V (n=1)", "A1698V (n=1)", "G667* (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=ov_tcga_pan_can_atlas_2018", "source_record_id": "ov_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Ovarian Cancer (CPTAC GDC, 2025)", "source_url": "https://www.cbioportal.org/study/summary?id=ovary_cptac_gdc", "source_record_id": "ovary_cptac_gdc", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg38", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas), 17/523 patients (3.25%).", "Without the 3 hypermutated patients: 16/520 (3.08%).", "Largest alteration is amplification: 24/572 (4.2%) in the reference cohort's copy-number profile.", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "ov_tcga_pan_can_atlas_2018", "cohort_name": "Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "altered": 17, "tested": 523, "frequency": 3.25, "frequency_excl_hypermutated": 3.08, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "523/585", "coverage_note": null, "source_id": "ov_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "ovary_cptac_gdc", "cohort_name": "Ovarian Cancer (CPTAC GDC, 2025)", "altered": 2, "tested": 95, "frequency": 2.11, "frequency_excl_hypermutated": 1.06, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "95/112", "coverage_note": null, "source_id": "ovary_cptac_gdc", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 14.0, "width": 1.0, "reference": 14.0, "scale_max": 30.0}, "headline_alteration": {"kind": "amplification", "altered": 24, "tested": 572, "frequency": 4.2, "is_mutation": false}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "PDE4DIP", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 17, "tested": 523, "frequency": 3.25, "cohort_count": 2, "frequency_range": {"min": 1.05, "max": 3.25}, "major_variants": ["E1315K (n=2)", "P993L (n=1)", "L2282M (n=1)", "E1147* (n=1)", "R419Vfs*21 (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=ov_tcga_pan_can_atlas_2018", "source_record_id": "ov_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Ovarian Cancer (CPTAC GDC, 2025)", "source_url": "https://www.cbioportal.org/study/summary?id=ovary_cptac_gdc", "source_record_id": "ovary_cptac_gdc", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg38", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas), 17/523 patients (3.25%).", "Without the 3 hypermutated patients: 16/520 (3.08%).", "Largest alteration is amplification: 38/572 (6.64%) in the reference cohort's copy-number profile.", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "ov_tcga_pan_can_atlas_2018", "cohort_name": "Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "altered": 17, "tested": 523, "frequency": 3.25, "frequency_excl_hypermutated": 3.08, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "523/585", "coverage_note": null, "source_id": "ov_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "ovary_cptac_gdc", "cohort_name": "Ovarian Cancer (CPTAC GDC, 2025)", "altered": 1, "tested": 95, "frequency": 1.05, "frequency_excl_hypermutated": 0.0, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "95/112", "coverage_note": null, "source_id": "ovary_cptac_gdc", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 22.13, "width": 1.0, "reference": 22.13, "scale_max": 30.0}, "headline_alteration": {"kind": "amplification", "altered": 38, "tested": 572, "frequency": 6.64, "is_mutation": false}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "RB1", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 16, "tested": 523, "frequency": 3.06, "cohort_count": 2, "frequency_range": {"min": 3.06, "max": 4.21}, "major_variants": ["A562P (n=1)", "I441Lfs*16 (n=1)", "R787* (n=1)", "Q702K (n=1)", "L486Ffs*9 (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=ov_tcga_pan_can_atlas_2018", "source_record_id": "ov_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Ovarian Cancer (CPTAC GDC, 2025)", "source_url": "https://www.cbioportal.org/study/summary?id=ovary_cptac_gdc", "source_record_id": "ovary_cptac_gdc", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg38", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas), 16/523 patients (3.06%).", "Without the 3 hypermutated patients: 15/520 (2.88%).", "Largest alteration is deep deletion: 49/572 (8.57%) in the reference cohort's copy-number profile.", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "ov_tcga_pan_can_atlas_2018", "cohort_name": "Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "altered": 16, "tested": 523, "frequency": 3.06, "frequency_excl_hypermutated": 2.88, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "523/585", "coverage_note": null, "source_id": "ov_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "ovary_cptac_gdc", "cohort_name": "Ovarian Cancer (CPTAC GDC, 2025)", "altered": 4, "tested": 95, "frequency": 4.21, "frequency_excl_hypermutated": 3.19, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "95/112", "coverage_note": null, "source_id": "ovary_cptac_gdc", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 28.57, "width": 1.0, "reference": 28.57, "scale_max": 30.0}, "headline_alteration": {"kind": "deep deletion", "altered": 49, "tested": 572, "frequency": 8.57, "is_mutation": false}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "PRUNE2", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 16, "tested": 523, "frequency": 3.06, "cohort_count": 2, "frequency_range": {"min": 2.11, "max": 3.06}, "major_variants": ["T758R (n=1)", "P289L (n=1)", "K1733N (n=1)", "A1525P (n=1)", "K350R (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=ov_tcga_pan_can_atlas_2018", "source_record_id": "ov_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Ovarian Cancer (CPTAC GDC, 2025)", "source_url": "https://www.cbioportal.org/study/summary?id=ovary_cptac_gdc", "source_record_id": "ovary_cptac_gdc", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg38", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas), 16/523 patients (3.06%).", "Without the 3 hypermutated patients: 16/520 (3.08%).", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "ov_tcga_pan_can_atlas_2018", "cohort_name": "Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "altered": 16, "tested": 523, "frequency": 3.06, "frequency_excl_hypermutated": 3.08, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "523/585", "coverage_note": null, "source_id": "ov_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "ovary_cptac_gdc", "cohort_name": "Ovarian Cancer (CPTAC GDC, 2025)", "altered": 2, "tested": 95, "frequency": 2.11, "frequency_excl_hypermutated": 1.06, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "95/112", "coverage_note": null, "source_id": "ovary_cptac_gdc", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 7.03, "width": 3.17, "reference": 10.2, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 16, "tested": 523, "frequency": 3.06, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "PCDH15", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 16, "tested": 523, "frequency": 3.06, "cohort_count": 2, "frequency_range": {"min": 3.06, "max": 4.21}, "major_variants": ["I1063N (n=1)", "T1258N (n=1)", "P315Q (n=1)", "T250N (n=1)", "D1521N (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=ov_tcga_pan_can_atlas_2018", "source_record_id": "ov_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Ovarian Cancer (CPTAC GDC, 2025)", "source_url": "https://www.cbioportal.org/study/summary?id=ovary_cptac_gdc", "source_record_id": "ovary_cptac_gdc", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg38", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas), 16/523 patients (3.06%).", "Without the 3 hypermutated patients: 15/520 (2.88%).", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "ov_tcga_pan_can_atlas_2018", "cohort_name": "Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "altered": 16, "tested": 523, "frequency": 3.06, "frequency_excl_hypermutated": 2.88, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "523/585", "coverage_note": null, "source_id": "ov_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "ovary_cptac_gdc", "cohort_name": "Ovarian Cancer (CPTAC GDC, 2025)", "altered": 4, "tested": 95, "frequency": 4.21, "frequency_excl_hypermutated": 3.19, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "95/112", "coverage_note": null, "source_id": "ovary_cptac_gdc", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 10.2, "width": 3.83, "reference": 10.2, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 16, "tested": 523, "frequency": 3.06, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "MYCBP2", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 16, "tested": 523, "frequency": 3.06, "cohort_count": 2, "frequency_range": {"min": 3.06, "max": 3.16}, "major_variants": ["S2691* (n=1)", "L1599I (n=1)", "L934V (n=1)", "L1521F (n=1)", "G2042A (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=ov_tcga_pan_can_atlas_2018", "source_record_id": "ov_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Ovarian Cancer (CPTAC GDC, 2025)", "source_url": "https://www.cbioportal.org/study/summary?id=ovary_cptac_gdc", "source_record_id": "ovary_cptac_gdc", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg38", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas), 16/523 patients (3.06%).", "Without the 3 hypermutated patients: 14/520 (2.69%).", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "ov_tcga_pan_can_atlas_2018", "cohort_name": "Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "altered": 16, "tested": 523, "frequency": 3.06, "frequency_excl_hypermutated": 2.69, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "523/585", "coverage_note": null, "source_id": "ov_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "ovary_cptac_gdc", "cohort_name": "Ovarian Cancer (CPTAC GDC, 2025)", "altered": 3, "tested": 95, "frequency": 3.16, "frequency_excl_hypermutated": 2.13, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "95/112", "coverage_note": null, "source_id": "ovary_cptac_gdc", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 10.2, "width": 1.0, "reference": 10.2, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 16, "tested": 523, "frequency": 3.06, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "KMT2A", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 16, "tested": 523, "frequency": 3.06, "cohort_count": 2, "frequency_range": {"min": 3.06, "max": 7.37}, "major_variants": ["S2088R (n=1)", "L3344F (n=1)", "D1693H (n=1)", "E1863Gfs*12 (n=1)", "R2480Tfs*4 (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=ov_tcga_pan_can_atlas_2018", "source_record_id": "ov_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Ovarian Cancer (CPTAC GDC, 2025)", "source_url": "https://www.cbioportal.org/study/summary?id=ovary_cptac_gdc", "source_record_id": "ovary_cptac_gdc", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg38", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas), 16/523 patients (3.06%).", "Without the 3 hypermutated patients: 14/520 (2.69%).", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "ov_tcga_pan_can_atlas_2018", "cohort_name": "Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "altered": 16, "tested": 523, "frequency": 3.06, "frequency_excl_hypermutated": 2.69, 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"is_demo": false}], "derived_insights": ["Reference cohort: Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas), 16/523 patients (3.06%).", "Without the 3 hypermutated patients: 14/520 (2.69%).", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "ov_tcga_pan_can_atlas_2018", "cohort_name": "Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "altered": 16, "tested": 523, "frequency": 3.06, "frequency_excl_hypermutated": 2.69, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "523/585", "coverage_note": null, "source_id": "ov_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "ovary_cptac_gdc", "cohort_name": "Ovarian Cancer (CPTAC GDC, 2025)", "altered": 7, "tested": 95, "frequency": 7.37, "frequency_excl_hypermutated": 6.38, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "95/112", "coverage_note": null, "source_id": "ovary_cptac_gdc", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 10.2, "width": 14.37, "reference": 10.2, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 16, "tested": 523, "frequency": 3.06, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "HIVEP3", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 16, "tested": 523, "frequency": 3.06, "cohort_count": 2, "frequency_range": {"min": 2.11, "max": 3.06}, "major_variants": ["I151M (n=1)", "R2171L (n=1)", "L1250I (n=1)", "S1504L (n=1)", "L2169V (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most 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{"source_name": "cBioPortal · Ovarian Cancer (CPTAC GDC, 2025)", "source_url": "https://www.cbioportal.org/study/summary?id=ovary_cptac_gdc", "source_record_id": "ovary_cptac_gdc", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg38", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas), 16/523 patients (3.06%).", "Without the 3 hypermutated patients: 15/520 (2.88%).", "Largest alteration is amplification: 45/572 (7.87%) in the reference cohort's copy-number profile.", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "ov_tcga_pan_can_atlas_2018", "cohort_name": "Ovarian Serous Cystadenocarcinoma 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"altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "DYSF", "alteration_types": ["SNV / small indel", "amplification"], "altered": 16, "tested": 523, "frequency": 3.06, "cohort_count": 2, "frequency_range": {"min": 1.05, "max": 3.06}, "major_variants": ["K1598N (n=1)", "N401K (n=1)", "T900A (n=1)", "G407C (n=1)", "W857L (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=ov_tcga_pan_can_atlas_2018", "source_record_id": "ov_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Ovarian Cancer (CPTAC GDC, 2025)", "source_url": "https://www.cbioportal.org/study/summary?id=ovary_cptac_gdc", "source_record_id": "ovary_cptac_gdc", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg38", "licence": "cBioPortal public data; the study's own 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"evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=ov_tcga_pan_can_atlas_2018", "source_record_id": "ov_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Ovarian Cancer (CPTAC GDC, 2025)", "source_url": "https://www.cbioportal.org/study/summary?id=ovary_cptac_gdc", "source_record_id": "ovary_cptac_gdc", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg38", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas), 15/523 patients (2.87%).", "Without the 3 hypermutated patients: 14/520 (2.69%).", "Largest alteration is amplification: 33/572 (5.77%) in the reference cohort's copy-number profile.", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "ov_tcga_pan_can_atlas_2018", "cohort_name": "Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "altered": 15, "tested": 523, "frequency": 2.87, "frequency_excl_hypermutated": 2.69, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "523/585", "coverage_note": null, "source_id": "ov_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "ovary_cptac_gdc", "cohort_name": "Ovarian Cancer (CPTAC GDC, 2025)", "altered": 4, "tested": 95, "frequency": 4.21, "frequency_excl_hypermutated": 3.19, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "95/112", "coverage_note": null, "source_id": "ovary_cptac_gdc", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 19.23, "width": 1.0, "reference": 19.23, "scale_max": 30.0}, "headline_alteration": {"kind": "amplification", "altered": 33, "tested": 572, "frequency": 5.77, "is_mutation": false}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "SZT2", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 15, "tested": 523, "frequency": 2.87, "cohort_count": 2, "frequency_range": {"min": 1.05, "max": 2.87}, "major_variants": ["Y205* (n=1)", "V1546I (n=1)", "G2532C (n=1)", "R1681C (n=1)", "E3126V (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=ov_tcga_pan_can_atlas_2018", "source_record_id": "ov_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Ovarian Cancer (CPTAC GDC, 2025)", "source_url": "https://www.cbioportal.org/study/summary?id=ovary_cptac_gdc", "source_record_id": "ovary_cptac_gdc", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg38", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas), 15/523 patients (2.87%).", "Without the 3 hypermutated patients: 13/520 (2.5%).", "Largest alteration is amplification: 38/572 (6.64%) in the reference cohort's copy-number profile.", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "ov_tcga_pan_can_atlas_2018", "cohort_name": "Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "altered": 15, "tested": 523, "frequency": 2.87, "frequency_excl_hypermutated": 2.5, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "523/585", "coverage_note": null, "source_id": "ov_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "ovary_cptac_gdc", "cohort_name": "Ovarian Cancer (CPTAC GDC, 2025)", "altered": 1, "tested": 95, "frequency": 1.05, "frequency_excl_hypermutated": 1.06, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "95/112", "coverage_note": null, "source_id": "ovary_cptac_gdc", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 22.13, "width": 1.0, "reference": 22.13, "scale_max": 30.0}, "headline_alteration": {"kind": "amplification", "altered": 38, "tested": 572, "frequency": 6.64, "is_mutation": false}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "NOTCH4", "alteration_types": ["SNV / small indel", "amplification"], "altered": 15, "tested": 523, "frequency": 2.87, "cohort_count": 2, "frequency_range": {"min": 2.11, "max": 2.87}, "major_variants": ["A1175T (n=1)", "X813_splice (n=1)", "Q1982Sfs*3 (n=1)", "N1996Kfs*7 (n=1)", "M252I (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=ov_tcga_pan_can_atlas_2018", "source_record_id": "ov_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Ovarian Cancer (CPTAC GDC, 2025)", "source_url": "https://www.cbioportal.org/study/summary?id=ovary_cptac_gdc", "source_record_id": "ovary_cptac_gdc", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg38", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas), 15/523 patients (2.87%).", "Without the 3 hypermutated patients: 13/520 (2.5%).", "Largest alteration is amplification: 19/572 (3.32%) in the reference cohort's copy-number profile.", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "ov_tcga_pan_can_atlas_2018", "cohort_name": "Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "altered": 15, "tested": 523, "frequency": 2.87, "frequency_excl_hypermutated": 2.5, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "523/585", "coverage_note": null, "source_id": "ov_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "ovary_cptac_gdc", "cohort_name": "Ovarian Cancer (CPTAC GDC, 2025)", "altered": 2, "tested": 95, "frequency": 2.11, "frequency_excl_hypermutated": 1.06, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "95/112", "coverage_note": null, "source_id": "ovary_cptac_gdc", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 11.07, "width": 1.0, "reference": 11.07, "scale_max": 30.0}, "headline_alteration": {"kind": "amplification", "altered": 19, "tested": 572, "frequency": 3.32, "is_mutation": false}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "CACNA1C", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 15, "tested": 523, "frequency": 2.87, "cohort_count": 2, "frequency_range": {"min": 2.87, "max": 5.26}, "major_variants": ["V1247I (n=1)", "L933M (n=1)", "A71E (n=1)", "A1747S (n=1)", "R462Q (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=ov_tcga_pan_can_atlas_2018", "source_record_id": "ov_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Ovarian Cancer (CPTAC GDC, 2025)", "source_url": "https://www.cbioportal.org/study/summary?id=ovary_cptac_gdc", "source_record_id": "ovary_cptac_gdc", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg38", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas), 15/523 patients (2.87%).", "Without the 3 hypermutated patients: 15/520 (2.88%).", "Largest alteration is amplification: 41/572 (7.17%) in the reference cohort's copy-number profile.", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "ov_tcga_pan_can_atlas_2018", "cohort_name": "Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "altered": 15, "tested": 523, "frequency": 2.87, 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"patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "VPS13C", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 14, "tested": 523, "frequency": 2.68, "cohort_count": 2, "frequency_range": {"min": 2.11, "max": 2.68}, "major_variants": ["E994D (n=1)", "Q268K (n=1)", "Q623K (n=1)", "M3080I (n=1)", "S1022C (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Ovarian Serous 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others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas), 14/523 patients (2.68%).", "Without the 3 hypermutated patients: 12/520 (2.31%).", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "ov_tcga_pan_can_atlas_2018", "cohort_name": "Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "altered": 14, "tested": 523, "frequency": 2.68, "frequency_excl_hypermutated": 2.31, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "523/585", "coverage_note": null, "source_id": "ov_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "ovary_cptac_gdc", "cohort_name": "Ovarian Cancer (CPTAC GDC, 2025)", "altered": 2, "tested": 95, "frequency": 2.11, "frequency_excl_hypermutated": 1.06, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "95/112", "coverage_note": null, "source_id": "ovary_cptac_gdc", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 7.03, "width": 1.9, "reference": 8.93, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 14, "tested": 523, "frequency": 2.68, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "UBR4", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 14, "tested": 523, "frequency": 2.68, "cohort_count": 2, "frequency_range": {"min": 2.11, "max": 2.68}, "major_variants": ["R4115T (n=1)", "P2610Q (n=1)", "R1336L (n=1)", "E3604* (n=1)", "P2467L (n=1)"], "evidence_confidence": "moderate", "disease_relevance": 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"is_demo": false}, {"source_name": "cBioPortal · Ovarian Cancer (CPTAC GDC, 2025)", "source_url": "https://www.cbioportal.org/study/summary?id=ovary_cptac_gdc", "source_record_id": "ovary_cptac_gdc", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg38", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas), 14/523 patients (2.68%).", "Without the 3 hypermutated patients: 12/520 (2.31%).", "Observed in 2 of 2 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "ov_tcga_pan_can_atlas_2018", "cohort_name": "Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "altered": 14, "tested": 523, "frequency": 2.68, 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"tested_unit": "patients", "frequency": 15.73, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["ov_tcga_pan_can_atlas_2018"], "source_ids": ["ov_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "VPS13B", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "VPS13B amplification", "genomic_coordinate": null, "observed": 62, "observed_status": "observed", "observed_unit": "patients", "tested": 572, "tested_status": "observed", "tested_unit": "patients", "frequency": 10.84, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["ov_tcga_pan_can_atlas_2018"], "source_ids": ["ov_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "KRAS", "denominator_note": "Patients in the cohort's copy-number sample list.", 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["ov_tcga_pan_can_atlas_2018"], "source_ids": ["ov_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "RB1", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "deep deletion", "event_label": "RB1 deep deletion", "genomic_coordinate": null, "observed": 49, "observed_status": "observed", "observed_unit": "patients", "tested": 572, "tested_status": "observed", "tested_unit": "patients", "frequency": 8.57, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["ov_tcga_pan_can_atlas_2018"], "source_ids": ["ov_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "HIVEP3", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "HIVEP3 amplification", "genomic_coordinate": null, "observed": 45, "observed_status": "observed", "observed_unit": "patients", "tested": 572, "tested_status": "observed", "tested_unit": "patients", "frequency": 7.87, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["ov_tcga_pan_can_atlas_2018"], "source_ids": ["ov_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "KMT2C", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "KMT2C amplification", "genomic_coordinate": null, "observed": 42, "observed_status": "observed", "observed_unit": "patients", "tested": 572, "tested_status": "observed", "tested_unit": "patients", "frequency": 7.34, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["ov_tcga_pan_can_atlas_2018"], "source_ids": ["ov_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "CACNA1C", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "CACNA1C amplification", "genomic_coordinate": null, "observed": 41, "observed_status": "observed", "observed_unit": "patients", "tested": 572, "tested_status": "observed", "tested_unit": "patients", "frequency": 7.17, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["ov_tcga_pan_can_atlas_2018"], "source_ids": ["ov_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "PDE4DIP", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "PDE4DIP amplification", "genomic_coordinate": null, "observed": 38, "observed_status": "observed", "observed_unit": "patients", "tested": 572, "tested_status": "observed", "tested_unit": "patients", "frequency": 6.64, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["ov_tcga_pan_can_atlas_2018"], "source_ids": ["ov_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "SZT2", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "SZT2 amplification", "genomic_coordinate": null, "observed": 38, "observed_status": "observed", "observed_unit": "patients", "tested": 572, "tested_status": "observed", "tested_unit": "patients", "frequency": 6.64, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["ov_tcga_pan_can_atlas_2018"], "source_ids": ["ov_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "NF1", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "deep deletion", "event_label": "NF1 deep deletion", "genomic_coordinate": null, "observed": 36, "observed_status": "observed", "observed_unit": "patients", "tested": 572, "tested_status": "observed", "tested_unit": "patients", "frequency": 6.29, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["ov_tcga_pan_can_atlas_2018"], "source_ids": ["ov_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "VWF", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "VWF amplification", "genomic_coordinate": null, "observed": 33, "observed_status": "observed", "observed_unit": "patients", "tested": 572, "tested_status": "observed", "tested_unit": "patients", "frequency": 5.77, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["ov_tcga_pan_can_atlas_2018"], "source_ids": ["ov_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "FOLR1", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "FOLR1 amplification", "genomic_coordinate": null, "observed": 27, "observed_status": "observed", "observed_unit": "patients", "tested": 572, "tested_status": "observed", "tested_unit": "patients", "frequency": 4.72, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["ov_tcga_pan_can_atlas_2018"], "source_ids": ["ov_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "PTEN", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "deep deletion", "event_label": "PTEN deep deletion", "genomic_coordinate": null, "observed": 26, "observed_status": "observed", "observed_unit": "patients", "tested": 572, "tested_status": "observed", "tested_unit": "patients", "frequency": 4.55, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["ov_tcga_pan_can_atlas_2018"], "source_ids": ["ov_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "MUC16", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "MUC16 amplification", "genomic_coordinate": null, "observed": 24, "observed_status": "observed", "observed_unit": "patients", "tested": 572, "tested_status": "observed", "tested_unit": "patients", "frequency": 4.2, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["ov_tcga_pan_can_atlas_2018"], "source_ids": ["ov_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "PTPRZ1", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "PTPRZ1 amplification", "genomic_coordinate": null, "observed": 24, "observed_status": "observed", "observed_unit": "patients", "tested": 572, "tested_status": "observed", "tested_unit": "patients", "frequency": 4.2, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["ov_tcga_pan_can_atlas_2018"], "source_ids": ["ov_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "RNF213", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "RNF213 amplification", "genomic_coordinate": null, "observed": 22, "observed_status": "observed", "observed_unit": "patients", "tested": 572, "tested_status": "observed", "tested_unit": "patients", "frequency": 3.85, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["ov_tcga_pan_can_atlas_2018"], "source_ids": ["ov_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "RELN", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "RELN amplification", "genomic_coordinate": null, "observed": 19, "observed_status": "observed", "observed_unit": "patients", "tested": 572, "tested_status": "observed", "tested_unit": "patients", "frequency": 3.32, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["ov_tcga_pan_can_atlas_2018"], "source_ids": ["ov_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "NOTCH4", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "NOTCH4 amplification", "genomic_coordinate": null, "observed": 19, "observed_status": "observed", "observed_unit": "patients", "tested": 572, "tested_status": "observed", "tested_unit": "patients", "frequency": 3.32, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["ov_tcga_pan_can_atlas_2018"], "source_ids": ["ov_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "HUWE1", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "HUWE1 amplification", "genomic_coordinate": null, "observed": 17, "observed_status": "observed", "observed_unit": "patients", "tested": 572, "tested_status": "observed", "tested_unit": "patients", "frequency": 2.97, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["ov_tcga_pan_can_atlas_2018"], "source_ids": ["ov_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "PKHD1", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "PKHD1 amplification", "genomic_coordinate": null, "observed": 14, "observed_status": "observed", "observed_unit": "patients", "tested": 572, "tested_status": "observed", "tested_unit": "patients", "frequency": 2.45, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["ov_tcga_pan_can_atlas_2018"], "source_ids": ["ov_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "LRRK2", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "LRRK2 amplification", "genomic_coordinate": null, "observed": 13, "observed_status": "observed", "observed_unit": "patients", "tested": 572, "tested_status": "observed", "tested_unit": "patients", "frequency": 2.27, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["ov_tcga_pan_can_atlas_2018"], "source_ids": ["ov_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "DYNC1H1", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "DYNC1H1 amplification", "genomic_coordinate": null, "observed": 13, "observed_status": "observed", "observed_unit": "patients", "tested": 572, "tested_status": "observed", "tested_unit": "patients", "frequency": 2.27, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["ov_tcga_pan_can_atlas_2018"], "source_ids": ["ov_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "TACC2", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "TACC2 amplification", "genomic_coordinate": null, "observed": 13, "observed_status": "observed", "observed_unit": "patients", "tested": 572, "tested_status": "observed", "tested_unit": "patients", "frequency": 2.27, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["ov_tcga_pan_can_atlas_2018"], "source_ids": ["ov_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}], "modality_summary": [{"modality": "SNV / small indel", "available_cohorts": 2, "total_cohorts": 2}, {"modality": "Copy number (discrete)", "available_cohorts": 1, "total_cohorts": 2}, {"modality": "Structural variant (present, not read)", "available_cohorts": 1, "total_cohorts": 2}], "chromosome_summary": [], "cohorts": [{"name": "Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "source": "cBioPortal", "accession": "ov_tcga_pan_can_atlas_2018", "patients": {"value": 523, "status": "observed", "unit": "patients"}, "samples": {"value": 523, "status": "observed", "unit": "samples"}, "disease_subtype": "Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "assay_type": "exome or genome", "sequencing_method": "WES (523)", "genome_build": "hg19", "alteration_types_available": ["SNV", "small indel", "amplification", "deep deletion", "structural variant (profile present, not read)"], "genes_assayed": "all coding genes", "primary_or_metastatic": null, "age_group": null, "retrieved_at": "2026-09-18", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "source_record_id": "ov_tcga_pan_can_atlas_2018", "is_demo": false, "assay_coverage": {"patients_with_calls": 523, "patients_in_roster": 523, "frequencies_computed": true, "samples_sequenced": 523, "samples_in_study": 585, "hypermutated_patients": 3, "median_mutations_per_sample": 56, "reason": null}}, {"name": "Ovarian Cancer (CPTAC GDC, 2025)", "source": "cBioPortal", "accession": "ovary_cptac_gdc", "patients": {"value": 95, "status": "observed", "unit": "patients"}, "samples": {"value": 95, "status": "observed", "unit": "samples"}, "disease_subtype": "Ovarian Cancer (CPTAC GDC, 2025)", "assay_type": "exome or genome", "sequencing_method": "WES (95)", "genome_build": "hg38", "alteration_types_available": ["SNV", "small indel"], "genes_assayed": "all coding genes", "primary_or_metastatic": null, "age_group": null, "retrieved_at": "2026-09-18", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "source_record_id": "ovary_cptac_gdc", "is_demo": false, "assay_coverage": {"patients_with_calls": 95, "patients_in_roster": 95, "frequencies_computed": true, "samples_sequenced": 95, "samples_in_study": 112, "hypermutated_patients": 1, "median_mutations_per_sample": 62, "reason": null}}], "sources": [{"source_name": "cBioPortal · Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=ov_tcga_pan_can_atlas_2018", "source_record_id": "ov_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Ovarian Cancer (CPTAC GDC, 2025)", "source_url": "https://www.cbioportal.org/study/summary?id=ovary_cptac_gdc", "source_record_id": "ovary_cptac_gdc", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg38", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "limitations": ["A cBioPortal public-API snapshot retrieved 2026-09-18; the page does not refresh source data at request time.", "Counts are patients with at least one non-silent call in the study's sequenced sample list; silent, intronic and UTR calls are excluded.", "For targeted-panel cohorts each gene divides by the patients whose panel carried it; a gene absent from the panel is shown as not assayed, not as zero.", "Copy-number rows use discrete calls (2 = high-level amplification, −2 = deep deletion) against the cohort's copy-number sample list, which is a different roster from the sequenced one.", "Cohorts are not pooled. Cross-study patient overlap has not been checked and no disease-wide frequency is reported.", "Structural variants and fusions are not read in this snapshot even where the study carries a profile; germline variants, mutational signatures, TMB and MSI are not reported.", "The gene set is the briefing's curated targets plus the reference cohort's most frequently mutated genes; it is not genome-wide."], "answer_block": ["In Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas) (523 sequenced patients, exome or genome), the most frequently altered of the 48 genes shown are TP53 70.94%, TG 29.02% (amplification), PIK3CA 20.28% (amplification), CCNE1 19.58% (amplification), SI 15.73% (amplification). Each figure divides by the patients on whom that gene could be called.", "3 of 523 patients are hypermutated (more than 560 non-silent mutations, ten times the cohort median of 56); every gene's frequency without them is beside the headline.", "Of the briefing's 12 curated targets, 2 are altered in under 2% of this cohort (MSLN, ARID1A): targets by expression, dependency or drug label, not by mutation. Frequency is not targetability, in either direction.", "2 cohorts are shown and none are pooled; overlap between them has not been checked and there is no disease-wide percentage."], "key_findings": [{"finding": "TP53 is mutated in 371 of 523 patients in Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas).", "numerator": 371, "denominator": 523, "frequency": 70.94, "cohorts": 2, "evidence_confidence": "moderate", "source": "ov_tcga_pan_can_atlas_2018", "retrieved_at": "2026-09-18"}, {"finding": "TG is amplified in 166 of 572 patients in Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas).", "numerator": 166, "denominator": 572, "frequency": 29.02, "cohorts": 2, "evidence_confidence": "moderate", "source": "ov_tcga_pan_can_atlas_2018", "retrieved_at": "2026-09-18"}, {"finding": "PIK3CA is amplified in 116 of 572 patients in Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas).", "numerator": 116, "denominator": 572, "frequency": 20.28, "cohorts": 2, "evidence_confidence": "moderate", "source": "ov_tcga_pan_can_atlas_2018", "retrieved_at": "2026-09-18"}], "research_gaps": [{"kind": "Structural variants", "text": "Read the structural-variant profiles the studies carry; fusions are the defining event in several of these diseases."}, {"kind": "Context", "text": "Stage, subtype, age and treatment line are not attached to any count; the cohorts differ on all four."}, {"kind": "Interpretation", "text": "Activating versus inactivating, actionable versus not, and evidence level are not inferred here; the briefing's target table carries the drug and trial facts."}], "observations": [], "data_status": "PUBLIC SOURCE SNAPSHOT", "is_demo": false, "reference_cohort": "ov_tcga_pan_can_atlas_2018", "region_events": [], "matrix": [{"label": "TP53", "kind": "SNV / small indel", "gene": "TP53", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 70.94, "altered": 371, "tested": 523, "note": null}, {"cohort": "ovary_cptac_gdc", "status": "observed", "frequency": 77.89, "altered": 74, "tested": 95, "note": null}]}, {"label": "BRCA1", "kind": "SNV / small indel", "gene": "BRCA1", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.44, "altered": 18, "tested": 523, "note": null}, {"cohort": "ovary_cptac_gdc", "status": "observed", "frequency": 6.32, "altered": 6, "tested": 95, "note": null}]}, {"label": "BRCA2", "kind": "SNV / small indel", "gene": "BRCA2", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 2.87, "altered": 15, "tested": 523, "note": null}, {"cohort": "ovary_cptac_gdc", "status": "observed", "frequency": 3.16, "altered": 3, "tested": 95, "note": null}]}, {"label": "CCNE1", "kind": "SNV / small indel", "gene": "CCNE1", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 0.38, "altered": 2, "tested": 523, "note": null}, {"cohort": "ovary_cptac_gdc", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 95, "note": null}]}, {"label": "CCNE1", "kind": "amplification", "gene": "CCNE1", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 19.58, "altered": 112, "tested": 572, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "ovary_cptac_gdc", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "No copy-number profile is connected for this cohort."}]}, {"label": "FOLR1", "kind": "SNV / small indel", "gene": "FOLR1", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 0.57, "altered": 3, "tested": 523, "note": null}, {"cohort": "ovary_cptac_gdc", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 95, "note": null}]}, {"label": "FOLR1", "kind": "amplification", "gene": "FOLR1", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 4.72, "altered": 27, "tested": 572, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "ovary_cptac_gdc", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "No copy-number profile is connected for this cohort."}]}, {"label": "MUC16", "kind": "SNV / small indel", "gene": "MUC16", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 7.84, "altered": 41, "tested": 523, "note": null}, {"cohort": "ovary_cptac_gdc", "status": "observed", "frequency": 12.63, "altered": 12, "tested": 95, "note": null}]}, {"label": "MUC16", "kind": "amplification", "gene": "MUC16", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 4.2, "altered": 24, "tested": 572, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "ovary_cptac_gdc", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "No copy-number profile is connected for this cohort."}]}, {"label": "MSLN", "kind": "SNV / small indel", "gene": "MSLN", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 523, "note": null}, {"cohort": "ovary_cptac_gdc", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 95, "note": null}]}, {"label": "KRAS", "kind": "SNV / small indel", "gene": "KRAS", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 1.15, "altered": 6, "tested": 523, "note": null}, {"cohort": "ovary_cptac_gdc", "status": "observed", "frequency": 2.11, "altered": 2, "tested": 95, "note": null}]}, {"label": "KRAS", "kind": "amplification", "gene": "KRAS", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 9.44, "altered": 54, "tested": 572, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "ovary_cptac_gdc", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "No copy-number profile is connected for this cohort."}]}, {"label": "ARID1A", "kind": "SNV / small indel", "gene": "ARID1A", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 0.76, "altered": 4, "tested": 523, "note": null}, {"cohort": "ovary_cptac_gdc", "status": "observed", "frequency": 4.21, "altered": 4, "tested": 95, "note": null}]}, {"label": "PIK3CA", "kind": "SNV / small indel", "gene": "PIK3CA", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 1.53, "altered": 8, "tested": 523, "note": null}, {"cohort": "ovary_cptac_gdc", "status": "observed", "frequency": 3.16, "altered": 3, "tested": 95, "note": null}]}, {"label": "PIK3CA", "kind": "amplification", "gene": "PIK3CA", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 20.28, "altered": 116, "tested": 572, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "ovary_cptac_gdc", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "No copy-number profile is connected for this cohort."}]}, {"label": "PTEN", "kind": "SNV / small indel", "gene": "PTEN", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 1.34, "altered": 7, "tested": 523, "note": null}, {"cohort": "ovary_cptac_gdc", "status": "observed", "frequency": 3.16, "altered": 3, "tested": 95, "note": null}]}, {"label": "PTEN", "kind": "deep deletion", "gene": "PTEN", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 4.55, "altered": 26, "tested": 572, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "ovary_cptac_gdc", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "No copy-number profile is connected for this cohort."}]}, {"label": "NF1", "kind": "SNV / small indel", "gene": "NF1", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 5.74, "altered": 30, "tested": 523, "note": null}, {"cohort": "ovary_cptac_gdc", "status": "observed", "frequency": 3.16, "altered": 3, "tested": 95, "note": null}]}, {"label": "NF1", "kind": "deep deletion", "gene": "NF1", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 6.29, "altered": 36, "tested": 572, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "ovary_cptac_gdc", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "No copy-number profile is connected for this cohort."}]}, {"label": "KMT2C", "kind": "SNV / small indel", "gene": "KMT2C", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 4.59, "altered": 24, "tested": 523, "note": null}, {"cohort": "ovary_cptac_gdc", "status": "observed", "frequency": 5.26, "altered": 5, "tested": 95, "note": null}]}, {"label": "KMT2C", "kind": "amplification", "gene": "KMT2C", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 7.34, "altered": 42, "tested": 572, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "ovary_cptac_gdc", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "No copy-number profile is connected for this cohort."}]}, {"label": "SI", "kind": "SNV / small indel", "gene": "SI", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 4.21, "altered": 22, "tested": 523, "note": null}, {"cohort": "ovary_cptac_gdc", "status": "observed", "frequency": 3.16, "altered": 3, "tested": 95, "note": null}]}, {"label": "SI", "kind": "amplification", "gene": "SI", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 15.73, "altered": 90, "tested": 572, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "ovary_cptac_gdc", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "No copy-number profile is connected for this cohort."}]}, {"label": "MDN1", "kind": "SNV / small indel", "gene": "MDN1", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 4.02, "altered": 21, "tested": 523, "note": null}, {"cohort": "ovary_cptac_gdc", "status": "observed", "frequency": 3.16, "altered": 3, "tested": 95, "note": null}]}, {"label": "FCGBP", "kind": "SNV / small indel", "gene": "FCGBP", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 4.02, "altered": 21, "tested": 523, "note": null}, {"cohort": "ovary_cptac_gdc", "status": "observed", "frequency": 5.26, "altered": 5, "tested": 95, "note": null}]}, {"label": "FCGBP", "kind": "amplification", "gene": "FCGBP", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 8.74, "altered": 50, "tested": 572, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "ovary_cptac_gdc", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "No copy-number profile is connected for this cohort."}]}, {"label": "COL6A3", "kind": "SNV / small indel", "gene": "COL6A3", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 4.02, "altered": 21, "tested": 523, "note": null}, {"cohort": "ovary_cptac_gdc", "status": "observed", "frequency": 2.11, "altered": 2, "tested": 95, "note": null}]}, {"label": "TG", "kind": "SNV / small indel", "gene": "TG", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.82, "altered": 20, "tested": 523, "note": null}, {"cohort": "ovary_cptac_gdc", "status": "observed", "frequency": 8.42, "altered": 8, "tested": 95, "note": null}]}, {"label": "TG", "kind": "amplification", "gene": "TG", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 29.02, "altered": 166, "tested": 572, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "ovary_cptac_gdc", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "No copy-number profile is connected for this cohort."}]}, {"label": "MYH4", "kind": "SNV / small indel", "gene": "MYH4", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.82, "altered": 20, "tested": 523, "note": null}, {"cohort": "ovary_cptac_gdc", "status": "observed", "frequency": 4.21, "altered": 4, "tested": 95, "note": null}]}, {"label": "MYH1", "kind": "SNV / small indel", "gene": "MYH1", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.82, "altered": 20, "tested": 523, "note": null}, {"cohort": "ovary_cptac_gdc", "status": "observed", "frequency": 3.16, "altered": 3, "tested": 95, "note": null}]}, {"label": "LRP1", "kind": "SNV / small indel", "gene": "LRP1", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.82, "altered": 20, "tested": 523, "note": null}, {"cohort": "ovary_cptac_gdc", "status": "observed", "frequency": 2.11, "altered": 2, "tested": 95, "note": null}]}, {"label": "TOP2A", "kind": "SNV / small indel", "gene": "TOP2A", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.63, "altered": 19, "tested": 523, "note": null}, {"cohort": "ovary_cptac_gdc", "status": "observed", "frequency": 1.05, "altered": 1, "tested": 95, "note": null}]}, {"label": "SPEN", "kind": "SNV / small indel", "gene": "SPEN", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.63, "altered": 19, "tested": 523, "note": null}, {"cohort": "ovary_cptac_gdc", "status": "observed", "frequency": 3.16, "altered": 3, "tested": 95, "note": null}]}, {"label": "PKHD1", "kind": "SNV / small indel", "gene": "PKHD1", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.63, "altered": 19, "tested": 523, "note": null}, {"cohort": "ovary_cptac_gdc", "status": "observed", "frequency": 3.16, "altered": 3, "tested": 95, "note": null}]}, {"label": "PKHD1", "kind": "amplification", "gene": "PKHD1", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 2.45, "altered": 14, "tested": 572, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "ovary_cptac_gdc", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "No copy-number profile is connected for this cohort."}]}, {"label": "LRRK2", "kind": "SNV / small indel", "gene": "LRRK2", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.63, "altered": 19, "tested": 523, "note": null}, {"cohort": "ovary_cptac_gdc", "status": "observed", "frequency": 3.16, "altered": 3, "tested": 95, "note": null}]}, {"label": "LRRK2", "kind": "amplification", "gene": "LRRK2", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 2.27, "altered": 13, "tested": 572, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "ovary_cptac_gdc", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "No copy-number profile is connected for this cohort."}]}, {"label": "CDK12", "kind": "SNV / small indel", "gene": "CDK12", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.63, "altered": 19, "tested": 523, "note": null}, {"cohort": "ovary_cptac_gdc", "status": "observed", "frequency": 3.16, "altered": 3, "tested": 95, "note": null}]}, {"label": "VPS13B", "kind": "SNV / small indel", "gene": "VPS13B", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.44, "altered": 18, "tested": 523, "note": null}, {"cohort": "ovary_cptac_gdc", "status": "observed", "frequency": 3.16, "altered": 3, "tested": 95, "note": null}]}, {"label": "VPS13B", "kind": "amplification", "gene": "VPS13B", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 10.84, "altered": 62, "tested": 572, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "ovary_cptac_gdc", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "No copy-number profile is connected for this cohort."}]}, {"label": "PEG3", "kind": "SNV / small indel", "gene": "PEG3", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.44, "altered": 18, "tested": 523, "note": null}, {"cohort": "ovary_cptac_gdc", "status": "observed", "frequency": 3.16, "altered": 3, "tested": 95, "note": null}]}, {"label": "DYNC1H1", "kind": "SNV / small indel", "gene": "DYNC1H1", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.44, "altered": 18, "tested": 523, "note": null}, {"cohort": "ovary_cptac_gdc", "status": "observed", "frequency": 1.05, "altered": 1, "tested": 95, "note": null}]}, {"label": "DYNC1H1", "kind": "amplification", "gene": "DYNC1H1", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 2.27, "altered": 13, "tested": 572, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "ovary_cptac_gdc", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "No copy-number profile is connected for this cohort."}]}, {"label": "TACC2", "kind": "SNV / small indel", "gene": "TACC2", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.25, "altered": 17, "tested": 523, "note": null}, {"cohort": "ovary_cptac_gdc", "status": "observed", "frequency": 2.11, "altered": 2, "tested": 95, "note": null}]}, {"label": "TACC2", "kind": "amplification", "gene": "TACC2", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 2.27, "altered": 13, "tested": 572, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "ovary_cptac_gdc", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "No copy-number profile is connected for this cohort."}]}, {"label": "RELN", "kind": "SNV / small indel", "gene": "RELN", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.25, "altered": 17, "tested": 523, "note": null}, {"cohort": "ovary_cptac_gdc", "status": "observed", "frequency": 1.05, "altered": 1, "tested": 95, "note": null}]}, {"label": "RELN", "kind": "amplification", "gene": "RELN", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.32, "altered": 19, "tested": 572, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "ovary_cptac_gdc", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "No copy-number profile is connected for this cohort."}]}, {"label": "PTPRZ1", "kind": "SNV / small indel", "gene": "PTPRZ1", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.25, "altered": 17, "tested": 523, "note": null}, {"cohort": "ovary_cptac_gdc", "status": "observed", "frequency": 2.11, "altered": 2, "tested": 95, "note": null}]}, {"label": "PTPRZ1", "kind": "amplification", "gene": "PTPRZ1", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 4.2, "altered": 24, "tested": 572, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "ovary_cptac_gdc", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "No copy-number profile is connected for this cohort."}]}, {"label": "PDE4DIP", "kind": "SNV / small indel", "gene": "PDE4DIP", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.25, "altered": 17, "tested": 523, "note": null}, {"cohort": "ovary_cptac_gdc", "status": "observed", "frequency": 1.05, "altered": 1, "tested": 95, "note": null}]}, {"label": "PDE4DIP", "kind": "amplification", "gene": "PDE4DIP", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 6.64, "altered": 38, "tested": 572, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "ovary_cptac_gdc", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "No copy-number profile is connected for this cohort."}]}, {"label": "RB1", "kind": "SNV / small indel", "gene": "RB1", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.06, "altered": 16, "tested": 523, "note": null}, {"cohort": "ovary_cptac_gdc", "status": "observed", "frequency": 4.21, "altered": 4, "tested": 95, "note": null}]}, {"label": "RB1", "kind": "deep deletion", "gene": "RB1", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 8.57, "altered": 49, "tested": 572, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "ovary_cptac_gdc", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "No copy-number profile is connected for this cohort."}]}, {"label": "PRUNE2", "kind": "SNV / small indel", "gene": "PRUNE2", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.06, "altered": 16, "tested": 523, "note": null}, {"cohort": "ovary_cptac_gdc", "status": "observed", "frequency": 2.11, "altered": 2, "tested": 95, "note": null}]}, {"label": "PCDH15", "kind": "SNV / small indel", "gene": "PCDH15", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.06, "altered": 16, "tested": 523, "note": null}, {"cohort": "ovary_cptac_gdc", "status": "observed", "frequency": 4.21, "altered": 4, "tested": 95, "note": null}]}, {"label": "MYCBP2", "kind": "SNV / small indel", "gene": "MYCBP2", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.06, "altered": 16, "tested": 523, "note": null}, {"cohort": "ovary_cptac_gdc", "status": "observed", "frequency": 3.16, "altered": 3, "tested": 95, "note": null}]}, {"label": "KMT2A", "kind": "SNV / small indel", "gene": "KMT2A", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.06, "altered": 16, "tested": 523, "note": null}, {"cohort": "ovary_cptac_gdc", "status": "observed", "frequency": 7.37, "altered": 7, "tested": 95, "note": null}]}, {"label": "HUWE1", "kind": "SNV / small indel", "gene": "HUWE1", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.06, "altered": 16, "tested": 523, "note": null}, {"cohort": "ovary_cptac_gdc", "status": "observed", "frequency": 7.37, "altered": 7, "tested": 95, "note": null}]}, {"label": "HUWE1", "kind": "amplification", "gene": "HUWE1", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 2.97, "altered": 17, "tested": 572, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "ovary_cptac_gdc", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "No copy-number profile is connected for this cohort."}]}, {"label": "HIVEP3", "kind": "SNV / small indel", "gene": "HIVEP3", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.06, "altered": 16, "tested": 523, "note": null}, {"cohort": "ovary_cptac_gdc", "status": "observed", "frequency": 2.11, "altered": 2, "tested": 95, "note": null}]}, {"label": "HIVEP3", "kind": "amplification", "gene": "HIVEP3", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 7.87, "altered": 45, "tested": 572, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "ovary_cptac_gdc", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "No copy-number profile is connected for this cohort."}]}, {"label": "DYSF", "kind": "SNV / small indel", "gene": "DYSF", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.06, "altered": 16, "tested": 523, "note": null}, {"cohort": "ovary_cptac_gdc", "status": "observed", "frequency": 1.05, "altered": 1, "tested": 95, "note": null}]}, {"label": "VWF", "kind": "SNV / small indel", "gene": "VWF", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 2.87, "altered": 15, "tested": 523, "note": null}, {"cohort": "ovary_cptac_gdc", "status": "observed", "frequency": 4.21, "altered": 4, "tested": 95, "note": null}]}, {"label": "VWF", "kind": "amplification", "gene": "VWF", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 5.77, "altered": 33, "tested": 572, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "ovary_cptac_gdc", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "No copy-number profile is connected for this cohort."}]}, {"label": "SZT2", "kind": "SNV / small indel", "gene": "SZT2", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 2.87, "altered": 15, "tested": 523, "note": null}, {"cohort": "ovary_cptac_gdc", "status": "observed", "frequency": 1.05, "altered": 1, "tested": 95, "note": null}]}, {"label": "SZT2", "kind": "amplification", "gene": "SZT2", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 6.64, "altered": 38, "tested": 572, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "ovary_cptac_gdc", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "No copy-number profile is connected for this cohort."}]}, {"label": "NOTCH4", "kind": "SNV / small indel", "gene": "NOTCH4", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 2.87, "altered": 15, "tested": 523, "note": null}, {"cohort": "ovary_cptac_gdc", "status": "observed", "frequency": 2.11, "altered": 2, "tested": 95, "note": null}]}, {"label": "NOTCH4", "kind": "amplification", "gene": "NOTCH4", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.32, "altered": 19, "tested": 572, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "ovary_cptac_gdc", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "No copy-number profile is connected for this cohort."}]}, {"label": "CACNA1C", "kind": "SNV / small indel", "gene": "CACNA1C", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 2.87, "altered": 15, "tested": 523, "note": null}, {"cohort": "ovary_cptac_gdc", "status": "observed", "frequency": 5.26, "altered": 5, "tested": 95, "note": null}]}, {"label": "CACNA1C", "kind": "amplification", "gene": "CACNA1C", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 7.17, "altered": 41, "tested": 572, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "ovary_cptac_gdc", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "No copy-number profile is connected for this cohort."}]}, {"label": "VPS13C", "kind": "SNV / small indel", "gene": "VPS13C", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 2.68, "altered": 14, "tested": 523, "note": null}, {"cohort": "ovary_cptac_gdc", "status": "observed", "frequency": 2.11, "altered": 2, "tested": 95, "note": null}]}, {"label": "UBR4", "kind": "SNV / small indel", "gene": "UBR4", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 2.68, "altered": 14, "tested": 523, "note": null}, {"cohort": "ovary_cptac_gdc", "status": "observed", "frequency": 2.11, "altered": 2, "tested": 95, "note": null}]}, {"label": "RNF213", "kind": "SNV / small indel", "gene": "RNF213", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 2.68, "altered": 14, "tested": 523, "note": null}, {"cohort": "ovary_cptac_gdc", "status": "observed", "frequency": 3.16, "altered": 3, "tested": 95, "note": null}]}, {"label": "RNF213", "kind": "amplification", "gene": "RNF213", "cells": [{"cohort": "ov_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.85, "altered": 22, "tested": 572, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "ovary_cptac_gdc", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "No copy-number profile is connected for this cohort."}]}]}