{"disease": {"name": "Pancreatic cancer", "mondo_id": null, "ncit_id": null, "umls_id": null, "oncotree_code": "paad"}, "updated_at": "2026-09-18", "genome_builds": ["hg19"], "cohort_count": 3, "cohort_count_status": "observed", "cohort_count_unit": "cohorts", "evaluable_patients": null, "evaluable_patients_status": "unknown", "evaluable_patients_unit": "patients", "alteration_types": ["SNV", "small indel", "amplification", "deep deletion"], "genes": [{"gene": "KRAS", "alteration_types": ["SNV / small indel", "amplification"], "altered": 117, "tested": 179, "frequency": 65.36, "cohort_count": 3, "frequency_range": {"min": 65.36, "max": 93.66}, "major_variants": ["G12D (n=49)", "G12V (n=33)", "G12R (n=25)", "Q61H (n=6)", "Q61R (n=2)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_tcga_pan_can_atlas_2018", "source_record_id": "paad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_qcmg_uq_2016", "source_record_id": "paad_qcmg_uq_2016", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=pdac_msk_2024", "source_record_id": "pdac_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas), 117/179 patients (65.36%).", "Without the 1 hypermutated patients: 116/178 (65.17%).", "Observed in 3 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "paad_tcga_pan_can_atlas_2018", "cohort_name": "Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 117, "tested": 179, "frequency": 65.36, "frequency_excl_hypermutated": 65.17, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "179/184", "coverage_note": null, "source_id": "paad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "paad_qcmg_uq_2016", "cohort_name": "Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "altered": 344, "tested": 383, "frequency": 89.82, "frequency_excl_hypermutated": 90.0, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "383/456", "coverage_note": null, "source_id": "paad_qcmg_uq_2016", "is_reference": false}, {"cohort": "pdac_msk_2024", "cohort_name": "Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "altered": 2188, "tested": 2336, "frequency": 93.66, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "2336/2336", "coverage_note": null, "source_id": "pdac_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 100.0, "width": 1.0, "reference": 100.0, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 117, "tested": 179, "frequency": 65.36, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "TP53", "alteration_types": ["SNV / small indel", "deep deletion", "amplification"], "altered": 107, "tested": 179, "frequency": 59.78, "cohort_count": 3, "frequency_range": {"min": 59.78, "max": 76.07}, "major_variants": ["R175H (n=4)", "R248Q (n=4)", "R248W (n=4)", "R273H (n=3)", "R273C (n=3)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_tcga_pan_can_atlas_2018", "source_record_id": "paad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_qcmg_uq_2016", "source_record_id": "paad_qcmg_uq_2016", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=pdac_msk_2024", "source_record_id": "pdac_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas), 107/179 patients (59.78%).", "Without the 1 hypermutated patients: 107/178 (60.11%).", "Observed in 3 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "paad_tcga_pan_can_atlas_2018", "cohort_name": "Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 107, "tested": 179, "frequency": 59.78, "frequency_excl_hypermutated": 60.11, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "179/184", "coverage_note": null, "source_id": "paad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "paad_qcmg_uq_2016", "cohort_name": "Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "altered": 250, "tested": 383, "frequency": 65.27, "frequency_excl_hypermutated": 65.0, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "383/456", "coverage_note": null, "source_id": "paad_qcmg_uq_2016", "is_reference": false}, {"cohort": "pdac_msk_2024", "cohort_name": "Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "altered": 1777, "tested": 2336, "frequency": 76.07, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "2336/2336", "coverage_note": null, "source_id": "pdac_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 100.0, "width": 1.0, "reference": 100.0, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 107, "tested": 179, "frequency": 59.78, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "CDKN2A", "alteration_types": ["SNV / small indel", "deep deletion"], "altered": 35, "tested": 179, "frequency": 19.55, "cohort_count": 3, "frequency_range": {"min": 18.02, "max": 23.37}, "major_variants": ["R80* (n=6)", "H83Y (n=3)", "R58* (n=2)", "T18_A19dup (n=1)", "V28_E33del (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_tcga_pan_can_atlas_2018", "source_record_id": "paad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_qcmg_uq_2016", "source_record_id": "paad_qcmg_uq_2016", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=pdac_msk_2024", "source_record_id": "pdac_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas), 35/179 patients (19.55%).", "Without the 1 hypermutated patients: 35/178 (19.66%).", "Largest alteration is deep deletion: 52/183 (28.42%) in the reference cohort's copy-number profile.", "Observed in 3 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "paad_tcga_pan_can_atlas_2018", "cohort_name": "Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 35, "tested": 179, "frequency": 19.55, "frequency_excl_hypermutated": 19.66, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "179/184", "coverage_note": null, "source_id": "paad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "paad_qcmg_uq_2016", "cohort_name": "Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "altered": 69, "tested": 383, "frequency": 18.02, "frequency_excl_hypermutated": 17.89, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "383/456", "coverage_note": null, "source_id": "paad_qcmg_uq_2016", "is_reference": false}, {"cohort": "pdac_msk_2024", "cohort_name": "Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "altered": 546, "tested": 2336, "frequency": 23.37, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "2336/2336", "coverage_note": null, "source_id": "pdac_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 94.73, "width": 1.0, "reference": 94.73, "scale_max": 30.0}, "headline_alteration": {"kind": "deep deletion", "altered": 52, "tested": 183, "frequency": 28.42, "is_mutation": false}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "SMAD4", "alteration_types": ["SNV / small indel", "deep deletion"], "altered": 37, "tested": 179, "frequency": 20.67, "cohort_count": 3, "frequency_range": {"min": 20.67, "max": 22.19}, "major_variants": ["R361C (n=3)", "E520* (n=2)", "G352* (n=2)", "S227Vfs*14 (n=1)", "Q289* (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_tcga_pan_can_atlas_2018", "source_record_id": "paad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_qcmg_uq_2016", "source_record_id": "paad_qcmg_uq_2016", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=pdac_msk_2024", "source_record_id": "pdac_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas), 37/179 patients (20.67%).", "Without the 1 hypermutated patients: 36/178 (20.22%).", "Observed in 3 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "paad_tcga_pan_can_atlas_2018", "cohort_name": "Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 37, "tested": 179, "frequency": 20.67, "frequency_excl_hypermutated": 20.22, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "179/184", "coverage_note": null, "source_id": "paad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "paad_qcmg_uq_2016", "cohort_name": "Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "altered": 85, "tested": 383, "frequency": 22.19, "frequency_excl_hypermutated": 22.37, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "383/456", "coverage_note": null, "source_id": "paad_qcmg_uq_2016", "is_reference": false}, {"cohort": "pdac_msk_2024", "cohort_name": "Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "altered": 512, "tested": 2336, "frequency": 21.92, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "2336/2336", "coverage_note": null, "source_id": "pdac_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 68.9, "width": 5.07, "reference": 68.9, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 37, "tested": 179, "frequency": 20.67, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "BRCA2", "alteration_types": ["SNV / small indel", "amplification"], "altered": 2, "tested": 179, "frequency": 1.12, "cohort_count": 3, "frequency_range": {"min": 1.12, "max": 2.83}, "major_variants": ["V2716Wfs*17 (n=1)", "T1346N (n=1)", "N1642T (n=1)", "N1784Kfs*3 (n=1)", "I1017F (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_tcga_pan_can_atlas_2018", "source_record_id": "paad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_qcmg_uq_2016", "source_record_id": "paad_qcmg_uq_2016", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=pdac_msk_2024", "source_record_id": "pdac_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas), 2/179 patients (1.12%).", "Without the 1 hypermutated patients: 1/178 (0.56%).", "Observed in 3 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "paad_tcga_pan_can_atlas_2018", "cohort_name": "Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 2, "tested": 179, "frequency": 1.12, "frequency_excl_hypermutated": 0.56, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "179/184", "coverage_note": null, "source_id": "paad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "paad_qcmg_uq_2016", "cohort_name": "Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "altered": 7, "tested": 383, "frequency": 1.83, "frequency_excl_hypermutated": 1.84, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "383/456", "coverage_note": null, "source_id": "paad_qcmg_uq_2016", "is_reference": false}, {"cohort": "pdac_msk_2024", "cohort_name": "Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "altered": 66, "tested": 2336, "frequency": 2.83, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "2336/2336", "coverage_note": null, "source_id": "pdac_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 3.73, "width": 5.7, "reference": 3.73, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 2, "tested": 179, "frequency": 1.12, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "PALB2", "alteration_types": ["SNV / small indel"], "altered": 1, "tested": 179, "frequency": 0.56, "cohort_count": 3, "frequency_range": {"min": 0.52, "max": 0.64}, "major_variants": ["D595A (n=1)", "A308T (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_tcga_pan_can_atlas_2018", "source_record_id": "paad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_qcmg_uq_2016", "source_record_id": "paad_qcmg_uq_2016", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=pdac_msk_2024", "source_record_id": "pdac_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas), 1/179 patients (0.56%).", "Without the 1 hypermutated patients: 0/178 (0.0%).", "Observed in 3 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "paad_tcga_pan_can_atlas_2018", "cohort_name": "Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 1, "tested": 179, "frequency": 0.56, "frequency_excl_hypermutated": 0.0, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "179/184", "coverage_note": null, "source_id": "paad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "paad_qcmg_uq_2016", "cohort_name": "Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "altered": 2, "tested": 383, "frequency": 0.52, "frequency_excl_hypermutated": 0.53, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "383/456", "coverage_note": null, "source_id": "paad_qcmg_uq_2016", "is_reference": false}, {"cohort": "pdac_msk_2024", "cohort_name": "Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "altered": 15, "tested": 2336, "frequency": 0.64, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "2336/2336", "coverage_note": null, "source_id": "pdac_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 1.73, "width": 1.0, "reference": 1.87, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 1, "tested": 179, "frequency": 0.56, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "ATM", "alteration_types": ["SNV / small indel"], "altered": 8, "tested": 179, "frequency": 4.47, "cohort_count": 3, "frequency_range": {"min": 2.95, "max": 4.47}, "major_variants": ["R1898Q (n=1)", "G3030V (n=1)", "R337C (n=1)", "X947_splice (n=1)", "X633_splice (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_tcga_pan_can_atlas_2018", "source_record_id": "paad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_qcmg_uq_2016", "source_record_id": "paad_qcmg_uq_2016", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=pdac_msk_2024", "source_record_id": "pdac_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas), 8/179 patients (4.47%).", "Without the 1 hypermutated patients: 7/178 (3.93%).", "Observed in 3 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "paad_tcga_pan_can_atlas_2018", "cohort_name": "Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 8, "tested": 179, "frequency": 4.47, "frequency_excl_hypermutated": 3.93, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "179/184", "coverage_note": null, "source_id": "paad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "paad_qcmg_uq_2016", "cohort_name": "Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "altered": 13, "tested": 383, "frequency": 3.39, "frequency_excl_hypermutated": 3.42, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "383/456", "coverage_note": null, "source_id": "paad_qcmg_uq_2016", "is_reference": false}, {"cohort": "pdac_msk_2024", "cohort_name": "Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "altered": 69, "tested": 2336, "frequency": 2.95, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "2336/2336", "coverage_note": null, "source_id": "pdac_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 9.83, "width": 5.07, "reference": 14.9, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 8, "tested": 179, "frequency": 4.47, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "EGFR", "alteration_types": ["SNV / small indel", "amplification"], "altered": 1, "tested": 179, "frequency": 0.56, "cohort_count": 2, "frequency_range": {"min": 0.0, "max": 0.56}, "major_variants": ["R669* (n=1)", "D800G (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_tcga_pan_can_atlas_2018", "source_record_id": "paad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_qcmg_uq_2016", "source_record_id": "paad_qcmg_uq_2016", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=pdac_msk_2024", "source_record_id": "pdac_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas), 1/179 patients (0.56%).", "Without the 1 hypermutated patients: 0/178 (0.0%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "paad_tcga_pan_can_atlas_2018", "cohort_name": "Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 1, "tested": 179, "frequency": 0.56, "frequency_excl_hypermutated": 0.0, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "179/184", "coverage_note": null, "source_id": "paad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "paad_qcmg_uq_2016", "cohort_name": "Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "altered": 0, "tested": 383, "frequency": 0.0, "frequency_excl_hypermutated": 0.0, "counting_unit": "patients", "status": "not_observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "383/456", "coverage_note": null, "source_id": "paad_qcmg_uq_2016", "is_reference": false}, {"cohort": "pdac_msk_2024", "cohort_name": "Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "altered": 10, "tested": 2336, "frequency": 0.43, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "2336/2336", "coverage_note": null, "source_id": "pdac_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 0.0, "width": 1.87, "reference": 1.87, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 1, "tested": 179, "frequency": 0.56, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "MSLN", "alteration_types": [], "altered": 0, "tested": 179, "frequency": 0.0, "cohort_count": 0, "frequency_range": {"min": 0.0, "max": 0.0}, "major_variants": [], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_tcga_pan_can_atlas_2018", "source_record_id": "paad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_qcmg_uq_2016", "source_record_id": "paad_qcmg_uq_2016", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=pdac_msk_2024", "source_record_id": "pdac_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas), 0/179 patients (0.0%).", "Without the 1 hypermutated patients: 0/178 (0.0%).", "Observed in 0 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "paad_tcga_pan_can_atlas_2018", "cohort_name": "Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 0, "tested": 179, "frequency": 0.0, "frequency_excl_hypermutated": 0.0, "counting_unit": "patients", "status": "not_observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "179/184", "coverage_note": null, "source_id": "paad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "paad_qcmg_uq_2016", "cohort_name": "Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "altered": 0, "tested": 383, "frequency": 0.0, "frequency_excl_hypermutated": 0.0, "counting_unit": "patients", "status": "not_observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "383/456", "coverage_note": null, "source_id": "paad_qcmg_uq_2016", "is_reference": false}, {"cohort": "pdac_msk_2024", "cohort_name": "Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "2336/2336", "coverage_note": null, "source_id": "pdac_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 0.0, "width": 1.0, "reference": 0.0, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 0, "tested": 179, "frequency": 0.0, "is_mutation": true}, "altered_status": "not_observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "not_observed", "frequency_unit": "percent", "cohort_count_status": "not_observed", "cohort_count_unit": "cohorts"}, {"gene": "CLDN18", "alteration_types": ["SNV / small indel", "amplification"], "altered": 0, "tested": 179, "frequency": 0.0, "cohort_count": 1, "frequency_range": {"min": 0.0, "max": 0.26}, "major_variants": [], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_tcga_pan_can_atlas_2018", "source_record_id": "paad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_qcmg_uq_2016", "source_record_id": "paad_qcmg_uq_2016", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=pdac_msk_2024", "source_record_id": "pdac_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas), 0/179 patients (0.0%).", "Without the 1 hypermutated patients: 0/178 (0.0%).", "Largest alteration is amplification: 1/183 (0.55%) in the reference cohort's copy-number profile.", "Observed in 1 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "paad_tcga_pan_can_atlas_2018", "cohort_name": "Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 0, "tested": 179, "frequency": 0.0, "frequency_excl_hypermutated": 0.0, "counting_unit": "patients", "status": "not_observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "179/184", "coverage_note": null, "source_id": "paad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "paad_qcmg_uq_2016", "cohort_name": "Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "altered": 1, "tested": 383, "frequency": 0.26, "frequency_excl_hypermutated": 0.26, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "383/456", "coverage_note": null, "source_id": "paad_qcmg_uq_2016", "is_reference": false}, {"cohort": "pdac_msk_2024", "cohort_name": "Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "2336/2336", "coverage_note": null, "source_id": "pdac_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 1.83, "width": 1.0, "reference": 1.83, "scale_max": 30.0}, "headline_alteration": {"kind": "amplification", "altered": 1, "tested": 183, "frequency": 0.55, "is_mutation": false}, "altered_status": "not_observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "not_observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "CEACAM5", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 1, "tested": 179, "frequency": 0.56, "cohort_count": 1, "frequency_range": {"min": 0.0, "max": 0.56}, "major_variants": ["L462H (n=1)", "P525S (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_tcga_pan_can_atlas_2018", "source_record_id": "paad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_qcmg_uq_2016", "source_record_id": "paad_qcmg_uq_2016", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=pdac_msk_2024", "source_record_id": "pdac_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas), 1/179 patients (0.56%).", "Without the 1 hypermutated patients: 0/178 (0.0%).", "Largest alteration is amplification: 3/183 (1.64%) in the reference cohort's copy-number profile.", "Observed in 1 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "paad_tcga_pan_can_atlas_2018", "cohort_name": "Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 1, "tested": 179, "frequency": 0.56, "frequency_excl_hypermutated": 0.0, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "179/184", "coverage_note": null, "source_id": "paad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "paad_qcmg_uq_2016", "cohort_name": "Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "altered": 0, "tested": 383, "frequency": 0.0, "frequency_excl_hypermutated": 0.0, "counting_unit": "patients", "status": "not_observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "383/456", "coverage_note": null, "source_id": "paad_qcmg_uq_2016", "is_reference": false}, {"cohort": "pdac_msk_2024", "cohort_name": "Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "2336/2336", "coverage_note": null, "source_id": "pdac_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 5.47, "width": 1.0, "reference": 5.47, "scale_max": 30.0}, "headline_alteration": {"kind": "amplification", "altered": 3, "tested": 183, "frequency": 1.64, "is_mutation": false}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "MUC1", "alteration_types": ["SNV / small indel", "amplification"], "altered": 1, "tested": 179, "frequency": 0.56, "cohort_count": 2, "frequency_range": {"min": 0.26, "max": 0.56}, "major_variants": ["F306I (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Curated target in the disease briefing.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_tcga_pan_can_atlas_2018", "source_record_id": "paad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_qcmg_uq_2016", "source_record_id": "paad_qcmg_uq_2016", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=pdac_msk_2024", "source_record_id": "pdac_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas), 1/179 patients (0.56%).", "Without the 1 hypermutated patients: 0/178 (0.0%).", "Largest alteration is amplification: 7/183 (3.83%) in the reference cohort's copy-number profile.", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "paad_tcga_pan_can_atlas_2018", "cohort_name": "Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 1, "tested": 179, "frequency": 0.56, "frequency_excl_hypermutated": 0.0, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "179/184", "coverage_note": null, "source_id": "paad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "paad_qcmg_uq_2016", "cohort_name": "Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "altered": 1, "tested": 383, "frequency": 0.26, "frequency_excl_hypermutated": 0.26, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "383/456", "coverage_note": null, "source_id": "paad_qcmg_uq_2016", "is_reference": false}, {"cohort": "pdac_msk_2024", "cohort_name": "Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "2336/2336", "coverage_note": null, "source_id": "pdac_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 12.77, "width": 1.0, "reference": 12.77, "scale_max": 30.0}, "headline_alteration": {"kind": "amplification", "altered": 7, "tested": 183, "frequency": 3.83, "is_mutation": false}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "RNF43", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 11, "tested": 179, "frequency": 6.15, "cohort_count": 3, "frequency_range": {"min": 5.48, "max": 6.15}, "major_variants": ["Q22* (n=1)", "A11Lfs*27 (n=1)", "R145* (n=1)", "L61Qfs*13 (n=1)", "X125_splice (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_tcga_pan_can_atlas_2018", "source_record_id": "paad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_qcmg_uq_2016", "source_record_id": "paad_qcmg_uq_2016", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=pdac_msk_2024", "source_record_id": "pdac_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas), 11/179 patients (6.15%).", "Without the 1 hypermutated patients: 10/178 (5.62%).", "Observed in 3 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "paad_tcga_pan_can_atlas_2018", "cohort_name": "Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 11, "tested": 179, "frequency": 6.15, "frequency_excl_hypermutated": 5.62, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "179/184", "coverage_note": null, "source_id": "paad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "paad_qcmg_uq_2016", "cohort_name": "Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "altered": 21, "tested": 383, "frequency": 5.48, "frequency_excl_hypermutated": 5.26, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "383/456", "coverage_note": null, "source_id": "paad_qcmg_uq_2016", "is_reference": false}, {"cohort": "pdac_msk_2024", "cohort_name": "Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "altered": 142, "tested": 2336, "frequency": 6.08, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "2336/2336", "coverage_note": null, "source_id": "pdac_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 18.27, "width": 2.23, "reference": 20.5, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 11, "tested": 179, "frequency": 6.15, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "PCDH15", "alteration_types": ["SNV / small indel", "amplification"], "altered": 9, "tested": 179, "frequency": 5.03, "cohort_count": 2, "frequency_range": {"min": 2.61, "max": 5.03}, "major_variants": ["T1268K (n=1)", "V1549Cfs*13 (n=1)", "D470N (n=1)", "G737C (n=1)", "S1541I (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_tcga_pan_can_atlas_2018", "source_record_id": "paad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_qcmg_uq_2016", "source_record_id": "paad_qcmg_uq_2016", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=pdac_msk_2024", "source_record_id": "pdac_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas), 9/179 patients (5.03%).", "Without the 1 hypermutated patients: 8/178 (4.49%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "paad_tcga_pan_can_atlas_2018", "cohort_name": "Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 9, "tested": 179, "frequency": 5.03, "frequency_excl_hypermutated": 4.49, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "179/184", "coverage_note": null, "source_id": "paad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "paad_qcmg_uq_2016", "cohort_name": "Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "altered": 10, "tested": 383, "frequency": 2.61, "frequency_excl_hypermutated": 2.63, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "383/456", "coverage_note": null, "source_id": "paad_qcmg_uq_2016", "is_reference": false}, {"cohort": "pdac_msk_2024", "cohort_name": "Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "2336/2336", "coverage_note": null, "source_id": "pdac_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 8.7, "width": 8.07, "reference": 16.77, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 9, "tested": 179, "frequency": 5.03, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "ARID1A", "alteration_types": ["SNV / small indel", "deep deletion"], "altered": 9, "tested": 179, "frequency": 5.03, "cohort_count": 3, "frequency_range": {"min": 5.03, "max": 8.73}, "major_variants": ["E1542* (n=1)", "R1276* (n=1)", "X1239_splice (n=1)", "G1926Efs*30 (n=1)", "Q1947* (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_tcga_pan_can_atlas_2018", "source_record_id": "paad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_qcmg_uq_2016", "source_record_id": "paad_qcmg_uq_2016", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=pdac_msk_2024", "source_record_id": "pdac_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas), 9/179 patients (5.03%).", "Without the 1 hypermutated patients: 8/178 (4.49%).", "Observed in 3 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "paad_tcga_pan_can_atlas_2018", "cohort_name": "Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 9, "tested": 179, "frequency": 5.03, "frequency_excl_hypermutated": 4.49, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "179/184", "coverage_note": null, "source_id": "paad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "paad_qcmg_uq_2016", "cohort_name": "Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "altered": 29, "tested": 383, "frequency": 7.57, "frequency_excl_hypermutated": 7.37, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "383/456", "coverage_note": null, "source_id": "paad_qcmg_uq_2016", "is_reference": false}, {"cohort": "pdac_msk_2024", "cohort_name": "Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "altered": 204, "tested": 2336, "frequency": 8.73, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "2336/2336", "coverage_note": null, "source_id": "pdac_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 16.77, "width": 12.33, "reference": 16.77, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 9, "tested": 179, "frequency": 5.03, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "TGFBR2", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 8, "tested": 179, "frequency": 4.47, "cohort_count": 3, "frequency_range": {"min": 3.9, "max": 4.7}, "major_variants": ["D549Y (n=1)", "Q191* (n=1)", "L386Tfs*26 (n=1)", "E551V (n=1)", "R562C (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_tcga_pan_can_atlas_2018", "source_record_id": "paad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_qcmg_uq_2016", "source_record_id": "paad_qcmg_uq_2016", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=pdac_msk_2024", "source_record_id": "pdac_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas), 8/179 patients (4.47%).", "Without the 1 hypermutated patients: 7/178 (3.93%).", "Observed in 3 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "paad_tcga_pan_can_atlas_2018", "cohort_name": "Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 8, "tested": 179, "frequency": 4.47, "frequency_excl_hypermutated": 3.93, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "179/184", "coverage_note": null, "source_id": "paad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "paad_qcmg_uq_2016", "cohort_name": "Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "altered": 18, "tested": 383, "frequency": 4.7, "frequency_excl_hypermutated": 4.74, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "383/456", "coverage_note": null, "source_id": "paad_qcmg_uq_2016", "is_reference": false}, {"cohort": "pdac_msk_2024", "cohort_name": "Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "altered": 91, "tested": 2336, "frequency": 3.9, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "2336/2336", "coverage_note": null, "source_id": "pdac_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 13.0, "width": 2.67, "reference": 14.9, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 8, "tested": 179, "frequency": 4.47, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "RNF213", "alteration_types": ["SNV / small indel", "amplification"], "altered": 8, "tested": 179, "frequency": 4.47, "cohort_count": 2, "frequency_range": {"min": 1.31, "max": 4.47}, "major_variants": ["G3906R (n=1)", "R3386H (n=1)", "G3031D (n=1)", "R4338H (n=1)", "I835F (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_tcga_pan_can_atlas_2018", "source_record_id": "paad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_qcmg_uq_2016", "source_record_id": "paad_qcmg_uq_2016", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=pdac_msk_2024", "source_record_id": "pdac_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas), 8/179 patients (4.47%).", "Without the 1 hypermutated patients: 7/178 (3.93%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "paad_tcga_pan_can_atlas_2018", "cohort_name": "Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 8, "tested": 179, "frequency": 4.47, "frequency_excl_hypermutated": 3.93, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "179/184", "coverage_note": null, "source_id": "paad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "paad_qcmg_uq_2016", "cohort_name": "Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "altered": 5, "tested": 383, "frequency": 1.31, "frequency_excl_hypermutated": 0.53, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "383/456", "coverage_note": null, "source_id": "paad_qcmg_uq_2016", "is_reference": false}, {"cohort": "pdac_msk_2024", "cohort_name": "Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "2336/2336", "coverage_note": null, "source_id": "pdac_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 4.37, "width": 10.53, "reference": 14.9, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 8, "tested": 179, "frequency": 4.47, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "MYO18B", "alteration_types": ["SNV / small indel"], "altered": 8, "tested": 179, "frequency": 4.47, "cohort_count": 2, "frequency_range": {"min": 1.31, "max": 4.47}, "major_variants": ["R2358I (n=1)", "R379Q (n=1)", "D685H (n=1)", "V309L (n=1)", "A1934T (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_tcga_pan_can_atlas_2018", "source_record_id": "paad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_qcmg_uq_2016", "source_record_id": "paad_qcmg_uq_2016", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=pdac_msk_2024", "source_record_id": "pdac_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas), 8/179 patients (4.47%).", "Without the 1 hypermutated patients: 7/178 (3.93%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "paad_tcga_pan_can_atlas_2018", "cohort_name": "Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 8, "tested": 179, "frequency": 4.47, "frequency_excl_hypermutated": 3.93, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "179/184", "coverage_note": null, "source_id": "paad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "paad_qcmg_uq_2016", "cohort_name": "Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "altered": 5, "tested": 383, "frequency": 1.31, "frequency_excl_hypermutated": 1.05, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "383/456", "coverage_note": null, "source_id": "paad_qcmg_uq_2016", "is_reference": false}, {"cohort": "pdac_msk_2024", "cohort_name": "Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "2336/2336", "coverage_note": null, "source_id": "pdac_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 4.37, "width": 10.53, "reference": 14.9, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 8, "tested": 179, "frequency": 4.47, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "HECW2", "alteration_types": ["SNV / small indel", "amplification"], "altered": 8, "tested": 179, "frequency": 4.47, "cohort_count": 2, "frequency_range": {"min": 0.52, "max": 4.47}, "major_variants": ["R271H (n=2)", "H245R (n=1)", "E757K (n=1)", "I1319T (n=1)", "R958W (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_tcga_pan_can_atlas_2018", "source_record_id": "paad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_qcmg_uq_2016", "source_record_id": "paad_qcmg_uq_2016", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=pdac_msk_2024", "source_record_id": "pdac_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas), 8/179 patients (4.47%).", "Without the 1 hypermutated patients: 7/178 (3.93%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "paad_tcga_pan_can_atlas_2018", "cohort_name": "Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 8, "tested": 179, "frequency": 4.47, "frequency_excl_hypermutated": 3.93, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "179/184", "coverage_note": null, "source_id": "paad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "paad_qcmg_uq_2016", "cohort_name": "Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "altered": 2, "tested": 383, "frequency": 0.52, "frequency_excl_hypermutated": 0.53, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "383/456", "coverage_note": null, "source_id": "paad_qcmg_uq_2016", "is_reference": false}, {"cohort": "pdac_msk_2024", "cohort_name": "Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "2336/2336", "coverage_note": null, "source_id": "pdac_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 1.73, "width": 13.17, "reference": 14.9, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 8, "tested": 179, "frequency": 4.47, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "CACNA1B", "alteration_types": ["SNV / small indel", "amplification"], "altered": 8, "tested": 179, "frequency": 4.47, "cohort_count": 2, "frequency_range": {"min": 1.57, "max": 4.47}, "major_variants": ["R2184H (n=1)", "R1957H (n=1)", "T2024M (n=1)", "V1051M (n=1)", "V1375M (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_tcga_pan_can_atlas_2018", "source_record_id": "paad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_qcmg_uq_2016", "source_record_id": "paad_qcmg_uq_2016", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=pdac_msk_2024", "source_record_id": "pdac_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas), 8/179 patients (4.47%).", "Without the 1 hypermutated patients: 7/178 (3.93%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "paad_tcga_pan_can_atlas_2018", "cohort_name": "Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 8, "tested": 179, "frequency": 4.47, "frequency_excl_hypermutated": 3.93, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "179/184", "coverage_note": null, "source_id": "paad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "paad_qcmg_uq_2016", "cohort_name": "Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "altered": 6, "tested": 383, "frequency": 1.57, "frequency_excl_hypermutated": 1.32, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "383/456", "coverage_note": null, "source_id": "paad_qcmg_uq_2016", "is_reference": false}, {"cohort": "pdac_msk_2024", "cohort_name": "Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "2336/2336", "coverage_note": null, "source_id": "pdac_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 5.23, "width": 9.67, "reference": 14.9, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 8, "tested": 179, "frequency": 4.47, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "SCN5A", "alteration_types": ["SNV / small indel", "amplification"], "altered": 7, "tested": 179, "frequency": 3.91, "cohort_count": 2, "frequency_range": {"min": 1.57, "max": 3.91}, "major_variants": ["A185T (n=1)", "D1790N (n=1)", "A993T (n=1)", "R1027W (n=1)", "A949V (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_tcga_pan_can_atlas_2018", "source_record_id": "paad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_qcmg_uq_2016", "source_record_id": "paad_qcmg_uq_2016", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=pdac_msk_2024", "source_record_id": "pdac_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas), 7/179 patients (3.91%).", "Without the 1 hypermutated patients: 6/178 (3.37%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "paad_tcga_pan_can_atlas_2018", "cohort_name": "Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 7, "tested": 179, "frequency": 3.91, "frequency_excl_hypermutated": 3.37, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "179/184", "coverage_note": null, "source_id": "paad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "paad_qcmg_uq_2016", "cohort_name": "Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "altered": 6, "tested": 383, "frequency": 1.57, "frequency_excl_hypermutated": 1.32, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "383/456", "coverage_note": null, "source_id": "paad_qcmg_uq_2016", "is_reference": false}, {"cohort": "pdac_msk_2024", "cohort_name": "Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "2336/2336", "coverage_note": null, "source_id": "pdac_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 5.23, "width": 7.8, "reference": 13.03, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 7, "tested": 179, "frequency": 3.91, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "RREB1", "alteration_types": ["SNV / small indel"], "altered": 7, "tested": 179, "frequency": 3.91, "cohort_count": 2, "frequency_range": {"min": 1.31, "max": 3.91}, "major_variants": ["E955K (n=1)", "E312D (n=1)", "Q313* (n=1)", "A380T (n=1)", "C321Hfs*3 (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_tcga_pan_can_atlas_2018", "source_record_id": "paad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_qcmg_uq_2016", "source_record_id": "paad_qcmg_uq_2016", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=pdac_msk_2024", "source_record_id": "pdac_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas), 7/179 patients (3.91%).", "Without the 1 hypermutated patients: 6/178 (3.37%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "paad_tcga_pan_can_atlas_2018", "cohort_name": "Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 7, "tested": 179, "frequency": 3.91, "frequency_excl_hypermutated": 3.37, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "179/184", "coverage_note": null, "source_id": "paad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "paad_qcmg_uq_2016", "cohort_name": "Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "altered": 5, "tested": 383, "frequency": 1.31, "frequency_excl_hypermutated": 1.05, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "383/456", "coverage_note": null, "source_id": "paad_qcmg_uq_2016", "is_reference": false}, {"cohort": "pdac_msk_2024", "cohort_name": "Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "2336/2336", "coverage_note": null, "source_id": "pdac_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 4.37, "width": 8.66, "reference": 13.03, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 7, "tested": 179, "frequency": 3.91, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "RELN", "alteration_types": ["SNV / small indel", "amplification"], "altered": 7, "tested": 179, "frequency": 3.91, "cohort_count": 2, "frequency_range": {"min": 2.35, "max": 3.91}, "major_variants": ["D1215N (n=1)", "A150V (n=1)", "R2285H (n=1)", "V3365I (n=1)", "X1435_splice (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_tcga_pan_can_atlas_2018", "source_record_id": "paad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_qcmg_uq_2016", "source_record_id": "paad_qcmg_uq_2016", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=pdac_msk_2024", "source_record_id": "pdac_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas), 7/179 patients (3.91%).", "Without the 1 hypermutated patients: 6/178 (3.37%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "paad_tcga_pan_can_atlas_2018", "cohort_name": "Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 7, "tested": 179, "frequency": 3.91, "frequency_excl_hypermutated": 3.37, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "179/184", "coverage_note": null, "source_id": "paad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "paad_qcmg_uq_2016", "cohort_name": "Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "altered": 9, "tested": 383, "frequency": 2.35, "frequency_excl_hypermutated": 2.11, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "383/456", "coverage_note": null, "source_id": "paad_qcmg_uq_2016", "is_reference": false}, {"cohort": "pdac_msk_2024", "cohort_name": "Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "2336/2336", "coverage_note": null, "source_id": "pdac_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 7.83, "width": 5.2, "reference": 13.03, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 7, "tested": 179, "frequency": 3.91, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "PCDHB7", "alteration_types": ["SNV / small indel", "amplification"], "altered": 7, "tested": 179, "frequency": 3.91, "cohort_count": 1, "frequency_range": {"min": 0.0, "max": 3.91}, "major_variants": ["A676V (n=2)", "V709L (n=1)", "C712W (n=1)", "E29K (n=1)", "F764Y (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_tcga_pan_can_atlas_2018", "source_record_id": "paad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_qcmg_uq_2016", "source_record_id": "paad_qcmg_uq_2016", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=pdac_msk_2024", "source_record_id": "pdac_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas), 7/179 patients (3.91%).", "Without the 1 hypermutated patients: 6/178 (3.37%).", "Observed in 1 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "paad_tcga_pan_can_atlas_2018", "cohort_name": "Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 7, "tested": 179, "frequency": 3.91, "frequency_excl_hypermutated": 3.37, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "179/184", "coverage_note": null, "source_id": "paad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "paad_qcmg_uq_2016", "cohort_name": "Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "altered": 0, "tested": 383, "frequency": 0.0, "frequency_excl_hypermutated": 0.0, "counting_unit": "patients", "status": "not_observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "383/456", "coverage_note": null, "source_id": "paad_qcmg_uq_2016", "is_reference": false}, {"cohort": "pdac_msk_2024", "cohort_name": "Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "2336/2336", "coverage_note": null, "source_id": "pdac_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 0.0, "width": 13.03, "reference": 13.03, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 7, "tested": 179, "frequency": 3.91, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "MAP3K21", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 7, "tested": 179, "frequency": 3.91, "cohort_count": 1, "frequency_range": {"min": 0.0, "max": 3.91}, "major_variants": ["R575* (n=1)", "Y724* (n=1)", "V525M (n=1)", "E489D (n=1)", "M302* (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_tcga_pan_can_atlas_2018", "source_record_id": "paad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_qcmg_uq_2016", "source_record_id": "paad_qcmg_uq_2016", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=pdac_msk_2024", "source_record_id": "pdac_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas), 7/179 patients (3.91%).", "Without the 1 hypermutated patients: 6/178 (3.37%).", "Observed in 1 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "paad_tcga_pan_can_atlas_2018", "cohort_name": "Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 7, "tested": 179, "frequency": 3.91, "frequency_excl_hypermutated": 3.37, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "179/184", "coverage_note": null, "source_id": "paad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "paad_qcmg_uq_2016", "cohort_name": "Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "altered": 0, "tested": 383, "frequency": 0.0, "frequency_excl_hypermutated": 0.0, "counting_unit": "patients", "status": "not_observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "383/456", "coverage_note": null, "source_id": "paad_qcmg_uq_2016", "is_reference": false}, {"cohort": "pdac_msk_2024", "cohort_name": "Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "2336/2336", "coverage_note": null, "source_id": "pdac_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 0.0, "width": 13.03, "reference": 13.03, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 7, "tested": 179, "frequency": 3.91, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "KMT2D", "alteration_types": ["SNV / small indel", "deep deletion", "amplification"], "altered": 7, "tested": 179, "frequency": 3.91, "cohort_count": 3, "frequency_range": {"min": 3.91, "max": 4.96}, "major_variants": ["E517Sfs*413 (n=1)", "A2491Gfs*15 (n=1)", "L5219I (n=1)", "A4959V (n=1)", "A5118V (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_tcga_pan_can_atlas_2018", "source_record_id": "paad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_qcmg_uq_2016", "source_record_id": "paad_qcmg_uq_2016", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=pdac_msk_2024", "source_record_id": "pdac_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas), 7/179 patients (3.91%).", "Without the 1 hypermutated patients: 6/178 (3.37%).", "Observed in 3 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "paad_tcga_pan_can_atlas_2018", "cohort_name": "Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 7, "tested": 179, "frequency": 3.91, "frequency_excl_hypermutated": 3.37, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "179/184", "coverage_note": null, "source_id": "paad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "paad_qcmg_uq_2016", "cohort_name": "Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "altered": 19, "tested": 383, "frequency": 4.96, "frequency_excl_hypermutated": 4.47, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "383/456", "coverage_note": null, "source_id": "paad_qcmg_uq_2016", "is_reference": false}, {"cohort": "pdac_msk_2024", "cohort_name": "Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "altered": 100, "tested": 2336, "frequency": 4.28, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "2336/2336", "coverage_note": null, "source_id": "pdac_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 13.03, "width": 3.5, "reference": 13.03, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 7, "tested": 179, "frequency": 3.91, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "KMT2C", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 7, "tested": 179, "frequency": 3.91, "cohort_count": 3, "frequency_range": {"min": 3.12, "max": 4.96}, "major_variants": ["S888F (n=1)", "S1182* (n=1)", "P3905Lfs*29 (n=1)", "D1107G (n=1)", "I2122M (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_tcga_pan_can_atlas_2018", "source_record_id": "paad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_qcmg_uq_2016", "source_record_id": "paad_qcmg_uq_2016", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=pdac_msk_2024", "source_record_id": "pdac_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas), 7/179 patients (3.91%).", "Without the 1 hypermutated patients: 6/178 (3.37%).", "Observed in 3 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "paad_tcga_pan_can_atlas_2018", "cohort_name": "Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 7, "tested": 179, "frequency": 3.91, "frequency_excl_hypermutated": 3.37, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "179/184", "coverage_note": null, "source_id": "paad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "paad_qcmg_uq_2016", "cohort_name": "Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "altered": 19, "tested": 383, "frequency": 4.96, "frequency_excl_hypermutated": 4.47, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "383/456", "coverage_note": null, "source_id": "paad_qcmg_uq_2016", "is_reference": false}, {"cohort": "pdac_msk_2024", "cohort_name": "Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "altered": 73, "tested": 2336, "frequency": 3.12, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "2336/2336", "coverage_note": null, "source_id": "pdac_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 10.4, "width": 6.13, "reference": 13.03, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 7, "tested": 179, "frequency": 3.91, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "KDM6A", "alteration_types": ["SNV / small indel", "deep deletion"], "altered": 7, "tested": 179, "frequency": 3.91, "cohort_count": 3, "frequency_range": {"min": 3.13, "max": 3.91}, "major_variants": ["X642_splice (n=1)", "S238Lfs*6 (n=1)", "X188_splice (n=1)", "R922* (n=1)", "X1392_splice (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_tcga_pan_can_atlas_2018", "source_record_id": "paad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_qcmg_uq_2016", "source_record_id": "paad_qcmg_uq_2016", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=pdac_msk_2024", "source_record_id": "pdac_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas), 7/179 patients (3.91%).", "Without the 1 hypermutated patients: 7/178 (3.93%).", "Observed in 3 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "paad_tcga_pan_can_atlas_2018", "cohort_name": "Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 7, "tested": 179, "frequency": 3.91, "frequency_excl_hypermutated": 3.93, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "179/184", "coverage_note": null, "source_id": "paad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "paad_qcmg_uq_2016", "cohort_name": "Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "altered": 12, "tested": 383, "frequency": 3.13, "frequency_excl_hypermutated": 3.16, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "383/456", "coverage_note": null, "source_id": "paad_qcmg_uq_2016", "is_reference": false}, {"cohort": "pdac_msk_2024", "cohort_name": "Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "altered": 91, "tested": 2336, "frequency": 3.9, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "2336/2336", "coverage_note": null, "source_id": "pdac_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 10.43, "width": 2.6, "reference": 13.03, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 7, "tested": 179, "frequency": 3.91, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "GNAS", "alteration_types": ["SNV / small indel", "amplification"], "altered": 7, "tested": 179, "frequency": 3.91, "cohort_count": 3, "frequency_range": {"min": 2.61, "max": 3.91}, "major_variants": ["R201C (n=4)", "R201H (n=2)", "V184M (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_tcga_pan_can_atlas_2018", "source_record_id": "paad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_qcmg_uq_2016", "source_record_id": "paad_qcmg_uq_2016", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=pdac_msk_2024", "source_record_id": "pdac_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas), 7/179 patients (3.91%).", "Without the 1 hypermutated patients: 6/178 (3.37%).", "Observed in 3 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "paad_tcga_pan_can_atlas_2018", "cohort_name": "Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 7, "tested": 179, "frequency": 3.91, "frequency_excl_hypermutated": 3.37, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "179/184", "coverage_note": null, "source_id": "paad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "paad_qcmg_uq_2016", "cohort_name": "Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "altered": 10, "tested": 383, "frequency": 2.61, "frequency_excl_hypermutated": 2.37, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "383/456", "coverage_note": null, "source_id": "paad_qcmg_uq_2016", "is_reference": false}, {"cohort": "pdac_msk_2024", "cohort_name": "Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "altered": 76, "tested": 2336, "frequency": 3.25, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "2336/2336", "coverage_note": null, "source_id": "pdac_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 8.7, "width": 4.33, "reference": 13.03, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 7, "tested": 179, "frequency": 3.91, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "GLI3", "alteration_types": ["SNV / small indel", "amplification"], "altered": 7, "tested": 179, "frequency": 3.91, "cohort_count": 2, "frequency_range": {"min": 3.91, "max": 4.7}, "major_variants": ["V514M (n=1)", "R989W (n=1)", "T615S (n=1)", "R1182W (n=1)", "A1190T (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_tcga_pan_can_atlas_2018", "source_record_id": "paad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_qcmg_uq_2016", "source_record_id": "paad_qcmg_uq_2016", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=pdac_msk_2024", "source_record_id": "pdac_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas), 7/179 patients (3.91%).", "Without the 1 hypermutated patients: 6/178 (3.37%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "paad_tcga_pan_can_atlas_2018", "cohort_name": "Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 7, "tested": 179, "frequency": 3.91, "frequency_excl_hypermutated": 3.37, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "179/184", "coverage_note": null, "source_id": "paad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "paad_qcmg_uq_2016", "cohort_name": "Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "altered": 18, "tested": 383, "frequency": 4.7, "frequency_excl_hypermutated": 4.47, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "383/456", "coverage_note": null, "source_id": "paad_qcmg_uq_2016", "is_reference": false}, {"cohort": "pdac_msk_2024", "cohort_name": "Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "2336/2336", "coverage_note": null, "source_id": "pdac_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 13.03, "width": 2.64, "reference": 13.03, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 7, "tested": 179, "frequency": 3.91, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "FLNC", "alteration_types": ["SNV / small indel"], "altered": 7, "tested": 179, "frequency": 3.91, "cohort_count": 2, "frequency_range": {"min": 0.78, "max": 3.91}, "major_variants": ["D2389Kfs*2 (n=1)", "E48K (n=1)", "Y281C (n=1)", "S2428P (n=1)", "A2273T (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_tcga_pan_can_atlas_2018", "source_record_id": "paad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_qcmg_uq_2016", "source_record_id": "paad_qcmg_uq_2016", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=pdac_msk_2024", "source_record_id": "pdac_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas), 7/179 patients (3.91%).", "Without the 1 hypermutated patients: 6/178 (3.37%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "paad_tcga_pan_can_atlas_2018", "cohort_name": "Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 7, "tested": 179, "frequency": 3.91, "frequency_excl_hypermutated": 3.37, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "179/184", "coverage_note": null, "source_id": "paad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "paad_qcmg_uq_2016", "cohort_name": "Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "altered": 3, "tested": 383, "frequency": 0.78, "frequency_excl_hypermutated": 0.79, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "383/456", "coverage_note": null, "source_id": "paad_qcmg_uq_2016", "is_reference": false}, {"cohort": "pdac_msk_2024", "cohort_name": "Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "2336/2336", "coverage_note": null, "source_id": "pdac_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 2.6, "width": 10.43, "reference": 13.03, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 7, "tested": 179, "frequency": 3.91, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "FAT2", "alteration_types": ["SNV / small indel", "amplification"], "altered": 7, "tested": 179, "frequency": 3.91, "cohort_count": 2, "frequency_range": {"min": 0.78, "max": 3.91}, "major_variants": ["X3143_splice (n=1)", "A3940V (n=1)", "A3231T (n=1)", "A1078T (n=1)", "A3345V (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_tcga_pan_can_atlas_2018", "source_record_id": "paad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_qcmg_uq_2016", "source_record_id": "paad_qcmg_uq_2016", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=pdac_msk_2024", "source_record_id": "pdac_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas), 7/179 patients (3.91%).", "Without the 1 hypermutated patients: 6/178 (3.37%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "paad_tcga_pan_can_atlas_2018", "cohort_name": "Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 7, "tested": 179, "frequency": 3.91, "frequency_excl_hypermutated": 3.37, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "179/184", "coverage_note": null, "source_id": "paad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "paad_qcmg_uq_2016", "cohort_name": "Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "altered": 3, "tested": 383, "frequency": 0.78, "frequency_excl_hypermutated": 0.79, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "383/456", "coverage_note": null, "source_id": "paad_qcmg_uq_2016", "is_reference": false}, {"cohort": "pdac_msk_2024", "cohort_name": "Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "2336/2336", "coverage_note": null, "source_id": "pdac_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 2.6, "width": 10.43, "reference": 13.03, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 7, "tested": 179, "frequency": 3.91, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "DSCAML1", "alteration_types": ["SNV / small indel"], "altered": 7, "tested": 179, "frequency": 3.91, "cohort_count": 2, "frequency_range": {"min": 2.09, "max": 3.91}, "major_variants": ["R1080W (n=1)", "A2061T (n=1)", "A1617V (n=1)", "I1742L (n=1)", "T412M (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_tcga_pan_can_atlas_2018", "source_record_id": "paad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_qcmg_uq_2016", "source_record_id": "paad_qcmg_uq_2016", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=pdac_msk_2024", "source_record_id": "pdac_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas), 7/179 patients (3.91%).", "Without the 1 hypermutated patients: 6/178 (3.37%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "paad_tcga_pan_can_atlas_2018", "cohort_name": "Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 7, "tested": 179, "frequency": 3.91, "frequency_excl_hypermutated": 3.37, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "179/184", "coverage_note": null, "source_id": "paad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "paad_qcmg_uq_2016", "cohort_name": "Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "altered": 8, "tested": 383, "frequency": 2.09, "frequency_excl_hypermutated": 2.11, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "383/456", "coverage_note": null, "source_id": "paad_qcmg_uq_2016", "is_reference": false}, {"cohort": "pdac_msk_2024", "cohort_name": "Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "2336/2336", "coverage_note": null, "source_id": "pdac_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 6.97, "width": 6.06, "reference": 13.03, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 7, "tested": 179, "frequency": 3.91, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "COL6A2", "alteration_types": ["SNV / small indel", "amplification"], "altered": 7, "tested": 179, "frequency": 3.91, "cohort_count": 2, "frequency_range": {"min": 0.78, "max": 3.91}, "major_variants": ["V980M (n=2)", "A698V (n=1)", "V662M (n=1)", "R181H (n=1)", "V598E (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_tcga_pan_can_atlas_2018", "source_record_id": "paad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_qcmg_uq_2016", "source_record_id": "paad_qcmg_uq_2016", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=pdac_msk_2024", "source_record_id": "pdac_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas), 7/179 patients (3.91%).", "Without the 1 hypermutated patients: 6/178 (3.37%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "paad_tcga_pan_can_atlas_2018", "cohort_name": "Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 7, "tested": 179, "frequency": 3.91, "frequency_excl_hypermutated": 3.37, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "179/184", "coverage_note": null, "source_id": "paad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "paad_qcmg_uq_2016", "cohort_name": "Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "altered": 3, "tested": 383, "frequency": 0.78, "frequency_excl_hypermutated": 0.79, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "383/456", "coverage_note": null, "source_id": "paad_qcmg_uq_2016", "is_reference": false}, {"cohort": "pdac_msk_2024", "cohort_name": "Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "2336/2336", "coverage_note": null, "source_id": "pdac_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 2.6, "width": 10.43, "reference": 13.03, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 7, "tested": 179, "frequency": 3.91, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "APBA2", "alteration_types": ["SNV / small indel", "deep deletion"], "altered": 7, "tested": 179, "frequency": 3.91, "cohort_count": 2, "frequency_range": {"min": 0.52, "max": 3.91}, "major_variants": ["G294R (n=1)", "S283L (n=1)", "A523S (n=1)", "Q317H (n=1)", "V675M (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_tcga_pan_can_atlas_2018", "source_record_id": "paad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_qcmg_uq_2016", "source_record_id": "paad_qcmg_uq_2016", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=pdac_msk_2024", "source_record_id": "pdac_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas), 7/179 patients (3.91%).", "Without the 1 hypermutated patients: 6/178 (3.37%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "paad_tcga_pan_can_atlas_2018", "cohort_name": "Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 7, "tested": 179, "frequency": 3.91, "frequency_excl_hypermutated": 3.37, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "179/184", "coverage_note": null, "source_id": "paad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "paad_qcmg_uq_2016", "cohort_name": "Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "altered": 2, "tested": 383, "frequency": 0.52, "frequency_excl_hypermutated": 0.26, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "383/456", "coverage_note": null, "source_id": "paad_qcmg_uq_2016", "is_reference": false}, {"cohort": "pdac_msk_2024", "cohort_name": "Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "2336/2336", "coverage_note": null, "source_id": "pdac_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 1.73, "width": 11.3, "reference": 13.03, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 7, "tested": 179, "frequency": 3.91, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "ADAMTS12", "alteration_types": ["SNV / small indel", "amplification"], "altered": 7, "tested": 179, "frequency": 3.91, "cohort_count": 2, "frequency_range": {"min": 0.52, "max": 3.91}, "major_variants": ["E303* (n=1)", "N1006K (n=1)", "V1392M (n=1)", "X843_splice (n=1)", "E791K (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_tcga_pan_can_atlas_2018", "source_record_id": "paad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_qcmg_uq_2016", "source_record_id": "paad_qcmg_uq_2016", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=pdac_msk_2024", "source_record_id": "pdac_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas), 7/179 patients (3.91%).", "Without the 1 hypermutated patients: 6/178 (3.37%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "paad_tcga_pan_can_atlas_2018", "cohort_name": "Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 7, "tested": 179, "frequency": 3.91, "frequency_excl_hypermutated": 3.37, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "179/184", "coverage_note": null, "source_id": "paad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "paad_qcmg_uq_2016", "cohort_name": "Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "altered": 2, "tested": 383, "frequency": 0.52, "frequency_excl_hypermutated": 0.53, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "383/456", "coverage_note": null, "source_id": "paad_qcmg_uq_2016", "is_reference": false}, {"cohort": "pdac_msk_2024", "cohort_name": "Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "2336/2336", "coverage_note": null, "source_id": "pdac_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 1.73, "width": 11.3, "reference": 13.03, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 7, "tested": 179, "frequency": 3.91, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "TPO", "alteration_types": ["SNV / small indel", "amplification", "deep deletion"], "altered": 6, "tested": 179, "frequency": 3.35, "cohort_count": 2, "frequency_range": {"min": 1.83, "max": 3.35}, "major_variants": ["R602C (n=1)", "M58I (n=1)", "T57M (n=1)", "R602H (n=1)", "R189* (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_tcga_pan_can_atlas_2018", "source_record_id": "paad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_qcmg_uq_2016", "source_record_id": "paad_qcmg_uq_2016", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=pdac_msk_2024", "source_record_id": "pdac_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas), 6/179 patients (3.35%).", "Without the 1 hypermutated patients: 5/178 (2.81%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "paad_tcga_pan_can_atlas_2018", "cohort_name": "Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 6, "tested": 179, "frequency": 3.35, "frequency_excl_hypermutated": 2.81, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "179/184", "coverage_note": null, "source_id": "paad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "paad_qcmg_uq_2016", "cohort_name": "Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "altered": 7, "tested": 383, "frequency": 1.83, "frequency_excl_hypermutated": 1.84, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "383/456", "coverage_note": null, "source_id": "paad_qcmg_uq_2016", "is_reference": false}, {"cohort": "pdac_msk_2024", "cohort_name": "Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "2336/2336", "coverage_note": null, "source_id": "pdac_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 6.1, "width": 5.07, "reference": 11.17, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 6, "tested": 179, "frequency": 3.35, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "PEG3", "alteration_types": ["SNV / small indel", "amplification"], "altered": 6, "tested": 179, "frequency": 3.35, "cohort_count": 2, "frequency_range": {"min": 1.57, "max": 3.35}, "major_variants": ["E421G (n=1)", "K125N (n=1)", "R930H (n=1)", "A543T (n=1)", "T440I (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_tcga_pan_can_atlas_2018", "source_record_id": "paad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_qcmg_uq_2016", "source_record_id": "paad_qcmg_uq_2016", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=pdac_msk_2024", "source_record_id": "pdac_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas), 6/179 patients (3.35%).", "Without the 1 hypermutated patients: 5/178 (2.81%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "paad_tcga_pan_can_atlas_2018", "cohort_name": "Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 6, "tested": 179, "frequency": 3.35, "frequency_excl_hypermutated": 2.81, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "179/184", "coverage_note": null, "source_id": "paad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "paad_qcmg_uq_2016", "cohort_name": "Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "altered": 6, "tested": 383, "frequency": 1.57, "frequency_excl_hypermutated": 1.58, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "383/456", "coverage_note": null, "source_id": "paad_qcmg_uq_2016", "is_reference": false}, {"cohort": "pdac_msk_2024", "cohort_name": "Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "2336/2336", "coverage_note": null, "source_id": "pdac_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 5.23, "width": 5.94, "reference": 11.17, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 6, "tested": 179, "frequency": 3.35, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "PCDH9", "alteration_types": ["SNV / small indel", "deep deletion"], "altered": 6, "tested": 179, "frequency": 3.35, "cohort_count": 2, "frequency_range": {"min": 0.78, "max": 3.35}, "major_variants": ["A1225V (n=1)", "N1218Y (n=1)", "V116L (n=1)", "V193M (n=1)", "G1121* (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_tcga_pan_can_atlas_2018", "source_record_id": "paad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_qcmg_uq_2016", "source_record_id": "paad_qcmg_uq_2016", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=pdac_msk_2024", "source_record_id": "pdac_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas), 6/179 patients (3.35%).", "Without the 1 hypermutated patients: 5/178 (2.81%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "paad_tcga_pan_can_atlas_2018", "cohort_name": "Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 6, "tested": 179, "frequency": 3.35, "frequency_excl_hypermutated": 2.81, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "179/184", "coverage_note": null, "source_id": "paad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "paad_qcmg_uq_2016", "cohort_name": "Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "altered": 3, "tested": 383, "frequency": 0.78, "frequency_excl_hypermutated": 0.79, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "383/456", "coverage_note": null, "source_id": "paad_qcmg_uq_2016", "is_reference": false}, {"cohort": "pdac_msk_2024", "cohort_name": "Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "2336/2336", "coverage_note": null, "source_id": "pdac_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 2.6, "width": 8.57, "reference": 11.17, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 6, "tested": 179, "frequency": 3.35, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "NOS1", "alteration_types": ["SNV / small indel", "amplification"], "altered": 6, "tested": 179, "frequency": 3.35, "cohort_count": 2, "frequency_range": {"min": 1.83, "max": 3.35}, "major_variants": ["R672H (n=1)", "R1268Q (n=1)", "A188V (n=1)", "D655G (n=1)", "R121W (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_tcga_pan_can_atlas_2018", "source_record_id": "paad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_qcmg_uq_2016", "source_record_id": "paad_qcmg_uq_2016", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=pdac_msk_2024", "source_record_id": "pdac_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas), 6/179 patients (3.35%).", "Without the 1 hypermutated patients: 5/178 (2.81%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "paad_tcga_pan_can_atlas_2018", "cohort_name": "Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 6, "tested": 179, "frequency": 3.35, "frequency_excl_hypermutated": 2.81, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "179/184", "coverage_note": null, "source_id": "paad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "paad_qcmg_uq_2016", "cohort_name": "Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "altered": 7, "tested": 383, "frequency": 1.83, "frequency_excl_hypermutated": 1.58, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "383/456", "coverage_note": null, "source_id": "paad_qcmg_uq_2016", "is_reference": false}, {"cohort": "pdac_msk_2024", "cohort_name": "Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "2336/2336", "coverage_note": null, "source_id": "pdac_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 6.1, "width": 5.07, "reference": 11.17, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 6, "tested": 179, "frequency": 3.35, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "KCNA6", "alteration_types": ["SNV / small indel", "amplification"], "altered": 6, "tested": 179, "frequency": 3.35, "cohort_count": 2, "frequency_range": {"min": 0.78, "max": 3.35}, "major_variants": ["R281C (n=1)", "G255R (n=1)", "P70S (n=1)", "A284T (n=1)", "T268M (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_tcga_pan_can_atlas_2018", "source_record_id": "paad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_qcmg_uq_2016", "source_record_id": "paad_qcmg_uq_2016", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=pdac_msk_2024", "source_record_id": "pdac_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas), 6/179 patients (3.35%).", "Without the 1 hypermutated patients: 5/178 (2.81%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "paad_tcga_pan_can_atlas_2018", "cohort_name": "Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 6, "tested": 179, "frequency": 3.35, "frequency_excl_hypermutated": 2.81, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "179/184", "coverage_note": null, "source_id": "paad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "paad_qcmg_uq_2016", "cohort_name": "Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "altered": 3, "tested": 383, "frequency": 0.78, "frequency_excl_hypermutated": 0.53, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "383/456", "coverage_note": null, "source_id": "paad_qcmg_uq_2016", "is_reference": false}, {"cohort": "pdac_msk_2024", "cohort_name": "Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "2336/2336", "coverage_note": null, "source_id": "pdac_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 2.6, "width": 8.57, "reference": 11.17, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 6, "tested": 179, "frequency": 3.35, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "FN1", "alteration_types": ["SNV / small indel", "amplification"], "altered": 6, "tested": 179, "frequency": 3.35, "cohort_count": 2, "frequency_range": {"min": 1.83, "max": 3.35}, "major_variants": ["N416S (n=1)", "T667I (n=1)", "Q1615E (n=1)", "R903C (n=1)", "T405I (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_tcga_pan_can_atlas_2018", "source_record_id": "paad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_qcmg_uq_2016", "source_record_id": "paad_qcmg_uq_2016", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=pdac_msk_2024", "source_record_id": "pdac_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas), 6/179 patients (3.35%).", "Without the 1 hypermutated patients: 5/178 (2.81%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "paad_tcga_pan_can_atlas_2018", "cohort_name": "Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 6, "tested": 179, "frequency": 3.35, "frequency_excl_hypermutated": 2.81, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "179/184", "coverage_note": null, "source_id": "paad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "paad_qcmg_uq_2016", "cohort_name": "Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "altered": 7, "tested": 383, "frequency": 1.83, "frequency_excl_hypermutated": 1.32, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "383/456", "coverage_note": null, "source_id": "paad_qcmg_uq_2016", "is_reference": false}, {"cohort": "pdac_msk_2024", "cohort_name": "Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "2336/2336", "coverage_note": null, "source_id": "pdac_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 6.1, "width": 5.07, "reference": 11.17, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 6, "tested": 179, "frequency": 3.35, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "FLT4", "alteration_types": ["SNV / small indel", "amplification"], "altered": 6, "tested": 179, "frequency": 3.35, "cohort_count": 3, "frequency_range": {"min": 0.78, "max": 3.35}, "major_variants": ["R1145C (n=1)", "X226_splice (n=1)", "A1158V (n=1)", "G857R (n=1)", "L234M (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_tcga_pan_can_atlas_2018", "source_record_id": "paad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_qcmg_uq_2016", "source_record_id": "paad_qcmg_uq_2016", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=pdac_msk_2024", "source_record_id": "pdac_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas), 6/179 patients (3.35%).", "Without the 1 hypermutated patients: 5/178 (2.81%).", "Observed in 3 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "paad_tcga_pan_can_atlas_2018", "cohort_name": "Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 6, "tested": 179, "frequency": 3.35, "frequency_excl_hypermutated": 2.81, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "179/184", "coverage_note": null, "source_id": "paad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "paad_qcmg_uq_2016", "cohort_name": "Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "altered": 3, "tested": 383, "frequency": 0.78, "frequency_excl_hypermutated": 0.79, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "383/456", "coverage_note": null, "source_id": "paad_qcmg_uq_2016", "is_reference": false}, {"cohort": "pdac_msk_2024", "cohort_name": "Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "altered": 31, "tested": 2336, "frequency": 1.33, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "2336/2336", "coverage_note": null, "source_id": "pdac_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 2.6, "width": 8.57, "reference": 11.17, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 6, "tested": 179, "frequency": 3.35, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "FLNA", "alteration_types": ["SNV / small indel", "amplification"], "altered": 6, "tested": 179, "frequency": 3.35, "cohort_count": 2, "frequency_range": {"min": 0.52, "max": 3.35}, "major_variants": ["G1384C (n=1)", "Y1712C (n=1)", "G881S (n=1)", "S757N (n=1)", "K2289N (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_tcga_pan_can_atlas_2018", "source_record_id": "paad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_qcmg_uq_2016", "source_record_id": "paad_qcmg_uq_2016", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=pdac_msk_2024", "source_record_id": "pdac_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas), 6/179 patients (3.35%).", "Without the 1 hypermutated patients: 5/178 (2.81%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "paad_tcga_pan_can_atlas_2018", "cohort_name": "Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 6, "tested": 179, "frequency": 3.35, "frequency_excl_hypermutated": 2.81, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "179/184", "coverage_note": null, "source_id": "paad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "paad_qcmg_uq_2016", "cohort_name": "Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "altered": 2, "tested": 383, "frequency": 0.52, "frequency_excl_hypermutated": 0.26, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "383/456", "coverage_note": null, "source_id": "paad_qcmg_uq_2016", "is_reference": false}, {"cohort": "pdac_msk_2024", "cohort_name": "Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "2336/2336", "coverage_note": null, "source_id": "pdac_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 1.73, "width": 9.44, "reference": 11.17, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 6, "tested": 179, "frequency": 3.35, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "COL5A1", "alteration_types": ["SNV / small indel"], "altered": 6, "tested": 179, "frequency": 3.35, "cohort_count": 2, "frequency_range": {"min": 2.09, "max": 3.35}, "major_variants": ["P657L (n=2)", "R828W (n=1)", "R1709H (n=1)", "D382N (n=1)", "D195N (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_tcga_pan_can_atlas_2018", "source_record_id": "paad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_qcmg_uq_2016", "source_record_id": "paad_qcmg_uq_2016", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=pdac_msk_2024", "source_record_id": "pdac_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas), 6/179 patients (3.35%).", "Without the 1 hypermutated patients: 5/178 (2.81%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "paad_tcga_pan_can_atlas_2018", "cohort_name": "Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 6, "tested": 179, "frequency": 3.35, "frequency_excl_hypermutated": 2.81, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "179/184", "coverage_note": null, "source_id": "paad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "paad_qcmg_uq_2016", "cohort_name": "Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "altered": 8, "tested": 383, "frequency": 2.09, "frequency_excl_hypermutated": 1.84, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "383/456", "coverage_note": null, "source_id": "paad_qcmg_uq_2016", "is_reference": false}, {"cohort": "pdac_msk_2024", "cohort_name": "Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "2336/2336", "coverage_note": null, "source_id": "pdac_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 6.97, "width": 4.2, "reference": 11.17, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 6, "tested": 179, "frequency": 3.35, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "ADAMTS16", "alteration_types": ["SNV / small indel", "amplification"], "altered": 6, "tested": 179, "frequency": 3.35, "cohort_count": 2, "frequency_range": {"min": 1.31, "max": 3.35}, "major_variants": ["R878H (n=1)", "N636S (n=1)", "Q760* (n=1)", "R808Q (n=1)", "C1095Y (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_tcga_pan_can_atlas_2018", "source_record_id": "paad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_qcmg_uq_2016", "source_record_id": "paad_qcmg_uq_2016", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=pdac_msk_2024", "source_record_id": "pdac_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas), 6/179 patients (3.35%).", "Without the 1 hypermutated patients: 5/178 (2.81%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "paad_tcga_pan_can_atlas_2018", "cohort_name": "Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 6, "tested": 179, "frequency": 3.35, "frequency_excl_hypermutated": 2.81, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "179/184", "coverage_note": null, "source_id": "paad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "paad_qcmg_uq_2016", "cohort_name": "Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "altered": 5, "tested": 383, "frequency": 1.31, "frequency_excl_hypermutated": 1.05, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "383/456", "coverage_note": null, "source_id": "paad_qcmg_uq_2016", "is_reference": false}, {"cohort": "pdac_msk_2024", "cohort_name": "Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "2336/2336", "coverage_note": null, "source_id": "pdac_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 4.37, "width": 6.8, "reference": 11.17, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 6, "tested": 179, "frequency": 3.35, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}, {"gene": "ABTB3", "alteration_types": ["SNV / small indel"], "altered": 6, "tested": 179, "frequency": 3.35, "cohort_count": 2, "frequency_range": {"min": 0.26, "max": 3.35}, "major_variants": ["V819I (n=1)", "R1085M (n=1)", "L1067M (n=1)", "C844* (n=1)", "Q394H (n=1)"], "evidence_confidence": "moderate", "disease_relevance": "Among the most frequently mutated genes in the reference cohort.", "targetability": "See the disease briefing's target table; not inferred from frequency.", "approved_drugs_other_diseases": [], "neuroblastoma_trials": [], "limitations": ["Non-silent calls in the study's sequenced sample list; patients, not samples.", "Cohort rows are not pooled; a zero is a measured absence in that profile, a dot is a gene the panel did not carry."], "sources": [{"source_name": "cBioPortal · Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_tcga_pan_can_atlas_2018", "source_record_id": "paad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_qcmg_uq_2016", "source_record_id": "paad_qcmg_uq_2016", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=pdac_msk_2024", "source_record_id": "pdac_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "derived_insights": ["Reference cohort: Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas), 6/179 patients (3.35%).", "Without the 1 hypermutated patients: 5/178 (2.81%).", "Observed in 2 of 3 cohorts; frequencies are cohort-specific and not pooled."], "cohort_frequencies": [{"cohort": "paad_tcga_pan_can_atlas_2018", "cohort_name": "Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "altered": 6, "tested": 179, "frequency": 3.35, "frequency_excl_hypermutated": 2.81, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "179/184", "coverage_note": null, "source_id": "paad_tcga_pan_can_atlas_2018", "is_reference": true}, {"cohort": "paad_qcmg_uq_2016", "cohort_name": "Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "altered": 1, "tested": 383, "frequency": 0.26, "frequency_excl_hypermutated": 0.26, "counting_unit": "patients", "status": "observed", "assayed": true, "assay_note": null, "evaluable": true, "coverage": "383/456", "coverage_note": null, "source_id": "paad_qcmg_uq_2016", "is_reference": false}, {"cohort": "pdac_msk_2024", "cohort_name": "Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "altered": null, "tested": null, "frequency": null, "frequency_excl_hypermutated": null, "counting_unit": "patients", "status": "not_assayed", "assayed": false, "assay_note": "Not on this cohort's gene panel.", "evaluable": false, "coverage": "2336/2336", "coverage_note": null, "source_id": "pdac_msk_2024", "is_reference": false}], "hgnc_id": null, "ensembl_id": null, "chromosome": null, "range_plot": {"left": 0.87, "width": 10.3, "reference": 11.17, "scale_max": 30.0}, "headline_alteration": {"kind": "SNV / small indel", "altered": 6, "tested": 179, "frequency": 3.35, "is_mutation": true}, "altered_status": "observed", "altered_unit": "patients", "tested_status": "observed", "tested_unit": "patients", "frequency_status": "observed", "frequency_unit": "percent", "cohort_count_status": "observed", "cohort_count_unit": "cohorts"}], "variants": [], "genomic_events": [{"event_type": "copy_number", "gene": "CDKN2A", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "deep deletion", "event_label": "CDKN2A deep deletion", "genomic_coordinate": null, "observed": 52, "observed_status": "observed", "observed_unit": "patients", "tested": 183, "tested_status": "observed", "tested_unit": "patients", "frequency": 28.42, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["paad_tcga_pan_can_atlas_2018"], "source_ids": ["paad_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "CDKN2A", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "deep deletion", "event_label": "CDKN2A deep deletion", "genomic_coordinate": null, "observed": 359, "observed_status": "observed", "observed_unit": "patients", "tested": 2336, "tested_status": "observed", "tested_unit": "patients", "frequency": 15.37, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["pdac_msk_2024"], "source_ids": ["pdac_msk_2024_cna"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "SMAD4", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "deep deletion", "event_label": "SMAD4 deep deletion", "genomic_coordinate": null, "observed": 23, "observed_status": "observed", "observed_unit": "patients", "tested": 183, "tested_status": "observed", "tested_unit": "patients", "frequency": 12.57, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["paad_tcga_pan_can_atlas_2018"], "source_ids": ["paad_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "KRAS", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "KRAS amplification", "genomic_coordinate": null, "observed": 8, "observed_status": "observed", "observed_unit": "patients", "tested": 183, "tested_status": "observed", "tested_unit": "patients", "frequency": 4.37, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["paad_tcga_pan_can_atlas_2018"], "source_ids": ["paad_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "SMAD4", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "deep deletion", "event_label": "SMAD4 deep deletion", "genomic_coordinate": null, "observed": 102, "observed_status": "observed", "observed_unit": "patients", "tested": 2336, "tested_status": "observed", "tested_unit": "patients", "frequency": 4.37, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["pdac_msk_2024"], "source_ids": ["pdac_msk_2024_cna"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "MUC1", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "MUC1 amplification", "genomic_coordinate": null, "observed": 7, "observed_status": "observed", "observed_unit": "patients", "tested": 183, "tested_status": "observed", "tested_unit": "patients", "frequency": 3.83, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["paad_tcga_pan_can_atlas_2018"], "source_ids": ["paad_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "KDM6A", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "deep deletion", "event_label": "KDM6A deep deletion", "genomic_coordinate": null, "observed": 5, "observed_status": "observed", "observed_unit": "patients", "tested": 183, "tested_status": "observed", "tested_unit": "patients", "frequency": 2.73, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["paad_tcga_pan_can_atlas_2018"], "source_ids": ["paad_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "KCNA6", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "KCNA6 amplification", "genomic_coordinate": null, "observed": 5, "observed_status": "observed", "observed_unit": "patients", "tested": 183, "tested_status": "observed", "tested_unit": "patients", "frequency": 2.73, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["paad_tcga_pan_can_atlas_2018"], "source_ids": ["paad_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}, {"event_type": "copy_number", "gene": "FLNA", "denominator_note": "Patients in the cohort's copy-number sample list.", "partner_gene": null, "alteration": "amplification", "event_label": "FLNA amplification", "genomic_coordinate": null, "observed": 4, "observed_status": "observed", "observed_unit": "patients", "tested": 183, "tested_status": "observed", "tested_unit": "patients", "frequency": 2.19, "frequency_status": "observed", "frequency_unit": "percent", "cohorts": ["paad_tcga_pan_can_atlas_2018"], "source_ids": ["paad_tcga_pan_can_atlas_2018_gistic"], "evidence_confidence": "moderate", "details": null}], "modality_summary": [{"modality": "SNV / small indel", "available_cohorts": 3, "total_cohorts": 3}, {"modality": "Copy number (discrete)", "available_cohorts": 2, "total_cohorts": 3}, {"modality": "Structural variant (present, not read)", "available_cohorts": 2, "total_cohorts": 3}], "chromosome_summary": [], "cohorts": [{"name": "Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "source": "cBioPortal", "accession": "paad_tcga_pan_can_atlas_2018", "patients": {"value": 179, "status": "observed", "unit": "patients"}, "samples": {"value": 179, "status": "observed", "unit": "samples"}, "disease_subtype": "Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "assay_type": "exome or genome", "sequencing_method": "WES (179)", "genome_build": "hg19", "alteration_types_available": ["SNV", "small indel", "amplification", "deep deletion", "structural variant (profile present, not read)"], "genes_assayed": "all coding genes", "primary_or_metastatic": null, "age_group": null, "retrieved_at": "2026-09-18", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "source_record_id": "paad_tcga_pan_can_atlas_2018", "is_demo": false, "assay_coverage": {"patients_with_calls": 179, "patients_in_roster": 179, "frequencies_computed": true, "samples_sequenced": 179, "samples_in_study": 184, "hypermutated_patients": 1, "median_mutations_per_sample": 34, "reason": null}}, {"name": "Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "source": "cBioPortal", "accession": "paad_qcmg_uq_2016", "patients": {"value": 383, "status": "observed", "unit": "patients"}, "samples": {"value": 383, "status": "observed", "unit": "samples"}, "disease_subtype": "Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "assay_type": "exome or genome", "sequencing_method": "WES (383)", "genome_build": "hg19", "alteration_types_available": ["SNV", "small indel"], "genes_assayed": "all coding genes", "primary_or_metastatic": null, "age_group": null, "retrieved_at": "2026-09-18", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "source_record_id": "paad_qcmg_uq_2016", "is_demo": false, "assay_coverage": {"patients_with_calls": 383, "patients_in_roster": 383, "frequencies_computed": true, "samples_sequenced": 383, "samples_in_study": 456, "hypermutated_patients": 3, "median_mutations_per_sample": 31, "reason": null}}, {"name": "Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "source": "cBioPortal", "accession": "pdac_msk_2024", "patients": {"value": 2336, "status": "observed", "unit": "patients"}, "samples": {"value": 2336, "status": "observed", "unit": "samples"}, "disease_subtype": "Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "assay_type": "targeted panel", "sequencing_method": "IMPACT468 (1536), IMPACT410 (438), IMPACT505 (345), IMPACT341 (17)", "genome_build": "hg19", "alteration_types_available": ["SNV", "small indel", "amplification", "deep deletion", "structural variant (profile present, not read)"], "genes_assayed": "panel genes only; per-gene denominators", "primary_or_metastatic": null, "age_group": null, "retrieved_at": "2026-09-18", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "source_record_id": "pdac_msk_2024", "is_demo": false, "assay_coverage": {"patients_with_calls": 2336, "patients_in_roster": 2336, "frequencies_computed": true, "samples_sequenced": 2336, "samples_in_study": 2336, "hypermutated_patients": 0, "median_mutations_per_sample": 4.0, "reason": null}}], "sources": [{"source_name": "cBioPortal · Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_tcga_pan_can_atlas_2018", "source_record_id": "paad_tcga_pan_can_atlas_2018", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (QCMG, Nature 2016)", "source_url": "https://www.cbioportal.org/study/summary?id=paad_qcmg_uq_2016", "source_record_id": "paad_qcmg_uq_2016", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}, {"source_name": "cBioPortal · Pancreatic Adenocarcinoma (MSK, Nat Med 2024)", "source_url": "https://www.cbioportal.org/study/summary?id=pdac_msk_2024", "source_record_id": "pdac_msk_2024", "source_version": null, "retrieved_at": "2026-09-18", "processing_version": null, "normalization_method": "patient-level, non-silent calls, panel-aware denominator", "genome_build": "hg19", "licence": "cBioPortal public data; the study's own data-use terms apply (TCGA: open; TARGET: OCG terms; others as published).", "is_demo": false}], "limitations": ["A cBioPortal public-API snapshot retrieved 2026-09-18; the page does not refresh source data at request time.", "Counts are patients with at least one non-silent call in the study's sequenced sample list; silent, intronic and UTR calls are excluded.", "For targeted-panel cohorts each gene divides by the patients whose panel carried it; a gene absent from the panel is shown as not assayed, not as zero.", "Copy-number rows use discrete calls (2 = high-level amplification, −2 = deep deletion) against the cohort's copy-number sample list, which is a different roster from the sequenced one.", "Cohorts are not pooled. Cross-study patient overlap has not been checked and no disease-wide frequency is reported.", "Structural variants and fusions are not read in this snapshot even where the study carries a profile; germline variants, mutational signatures, TMB and MSI are not reported.", "The gene set is the briefing's curated targets plus the reference cohort's most frequently mutated genes; it is not genome-wide."], "answer_block": ["In Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas) (179 sequenced patients, exome or genome), the most frequently altered of the 47 genes shown are KRAS 65.36%, TP53 59.78%, CDKN2A 28.42% (deep deletion), SMAD4 20.67%, RNF43 6.15%. Each figure divides by the patients on whom that gene could be called.", "1 of 179 patients are hypermutated (more than 340 non-silent mutations, ten times the cohort median of 34); every gene's frequency without them is beside the headline.", "Of the briefing's 12 curated targets, 6 are altered in under 2% of this cohort (BRCA2, PALB2, EGFR, MSLN, CLDN18, CEACAM5): targets by expression, dependency or drug label, not by mutation. Frequency is not targetability, in either direction.", "3 cohorts are shown and none are pooled; overlap between them has not been checked and there is no disease-wide percentage."], "key_findings": [{"finding": "KRAS is mutated in 117 of 179 patients in Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas).", "numerator": 117, "denominator": 179, "frequency": 65.36, "cohorts": 3, "evidence_confidence": "moderate", "source": "paad_tcga_pan_can_atlas_2018", "retrieved_at": "2026-09-18"}, {"finding": "TP53 is mutated in 107 of 179 patients in Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas).", "numerator": 107, "denominator": 179, "frequency": 59.78, "cohorts": 3, "evidence_confidence": "moderate", "source": "paad_tcga_pan_can_atlas_2018", "retrieved_at": "2026-09-18"}, {"finding": "CDKN2A is deleted in 52 of 183 patients in Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas).", "numerator": 52, "denominator": 183, "frequency": 28.42, "cohorts": 3, "evidence_confidence": "moderate", "source": "paad_tcga_pan_can_atlas_2018", "retrieved_at": "2026-09-18"}], "research_gaps": [{"kind": "Structural variants", "text": "Read the structural-variant profiles the studies carry; fusions are the defining event in several of these diseases."}, {"kind": "Context", "text": "Stage, subtype, age and treatment line are not attached to any count; the cohorts differ on all four."}, {"kind": "Interpretation", "text": "Activating versus inactivating, actionable versus not, and evidence level are not inferred here; the briefing's target table carries the drug and trial facts."}], "observations": [], "data_status": "PUBLIC SOURCE SNAPSHOT", "is_demo": false, "reference_cohort": "paad_tcga_pan_can_atlas_2018", "region_events": [], "matrix": [{"label": "KRAS", "kind": "SNV / small indel", "gene": "KRAS", "cells": [{"cohort": "paad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 65.36, "altered": 117, "tested": 179, "note": null}, {"cohort": "paad_qcmg_uq_2016", "status": "observed", "frequency": 89.82, "altered": 344, "tested": 383, "note": null}, {"cohort": "pdac_msk_2024", "status": "observed", "frequency": 93.66, "altered": 2188, "tested": 2336, "note": null}]}, {"label": "KRAS", "kind": "amplification", "gene": "KRAS", "cells": [{"cohort": "paad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 4.37, "altered": 8, "tested": 183, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "paad_qcmg_uq_2016", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "No copy-number profile is connected for this cohort."}, {"cohort": "pdac_msk_2024", "status": "observed", "frequency": 1.88, "altered": 44, "tested": 2336, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "TP53", "kind": "SNV / small indel", "gene": "TP53", "cells": [{"cohort": "paad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 59.78, "altered": 107, "tested": 179, "note": null}, {"cohort": "paad_qcmg_uq_2016", "status": "observed", "frequency": 65.27, "altered": 250, "tested": 383, "note": null}, {"cohort": "pdac_msk_2024", "status": "observed", "frequency": 76.07, "altered": 1777, "tested": 2336, "note": null}]}, {"label": "CDKN2A", "kind": "SNV / small indel", "gene": "CDKN2A", "cells": [{"cohort": "paad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 19.55, "altered": 35, "tested": 179, "note": null}, {"cohort": "paad_qcmg_uq_2016", "status": "observed", "frequency": 18.02, "altered": 69, "tested": 383, "note": null}, {"cohort": "pdac_msk_2024", "status": "observed", "frequency": 23.37, "altered": 546, "tested": 2336, "note": null}]}, {"label": "CDKN2A", "kind": "deep deletion", "gene": "CDKN2A", "cells": [{"cohort": "paad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 28.42, "altered": 52, "tested": 183, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "paad_qcmg_uq_2016", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "No copy-number profile is connected for this cohort."}, {"cohort": "pdac_msk_2024", "status": "observed", "frequency": 15.37, "altered": 359, "tested": 2336, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "SMAD4", "kind": "SNV / small indel", "gene": "SMAD4", "cells": [{"cohort": "paad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 20.67, "altered": 37, "tested": 179, "note": null}, {"cohort": "paad_qcmg_uq_2016", "status": "observed", "frequency": 22.19, "altered": 85, "tested": 383, "note": null}, {"cohort": "pdac_msk_2024", "status": "observed", "frequency": 21.92, "altered": 512, "tested": 2336, "note": null}]}, {"label": "SMAD4", "kind": "deep deletion", "gene": "SMAD4", "cells": [{"cohort": "paad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 12.57, "altered": 23, "tested": 183, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "paad_qcmg_uq_2016", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "No copy-number profile is connected for this cohort."}, {"cohort": "pdac_msk_2024", "status": "observed", "frequency": 4.37, "altered": 102, "tested": 2336, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "BRCA2", "kind": "SNV / small indel", "gene": "BRCA2", "cells": [{"cohort": "paad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 1.12, "altered": 2, "tested": 179, "note": null}, {"cohort": "paad_qcmg_uq_2016", "status": "observed", "frequency": 1.83, "altered": 7, "tested": 383, "note": null}, {"cohort": "pdac_msk_2024", "status": "observed", "frequency": 2.83, "altered": 66, "tested": 2336, "note": null}]}, {"label": "PALB2", "kind": "SNV / small indel", "gene": "PALB2", "cells": [{"cohort": "paad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 0.56, "altered": 1, "tested": 179, "note": null}, {"cohort": "paad_qcmg_uq_2016", "status": "observed", "frequency": 0.52, "altered": 2, "tested": 383, "note": null}, {"cohort": "pdac_msk_2024", "status": "observed", "frequency": 0.64, "altered": 15, "tested": 2336, "note": null}]}, {"label": "ATM", "kind": "SNV / small indel", "gene": "ATM", "cells": [{"cohort": "paad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 4.47, "altered": 8, "tested": 179, "note": null}, {"cohort": "paad_qcmg_uq_2016", "status": "observed", "frequency": 3.39, "altered": 13, "tested": 383, "note": null}, {"cohort": "pdac_msk_2024", "status": "observed", "frequency": 2.95, "altered": 69, "tested": 2336, "note": null}]}, {"label": "EGFR", "kind": "SNV / small indel", "gene": "EGFR", "cells": [{"cohort": "paad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 0.56, "altered": 1, "tested": 179, "note": null}, {"cohort": "paad_qcmg_uq_2016", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 383, "note": null}, {"cohort": "pdac_msk_2024", "status": "observed", "frequency": 0.43, "altered": 10, "tested": 2336, "note": null}]}, {"label": "MSLN", "kind": "SNV / small indel", "gene": "MSLN", "cells": [{"cohort": "paad_tcga_pan_can_atlas_2018", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 179, "note": null}, {"cohort": "paad_qcmg_uq_2016", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 383, "note": null}, {"cohort": "pdac_msk_2024", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "CLDN18", "kind": "SNV / small indel", "gene": "CLDN18", "cells": [{"cohort": "paad_tcga_pan_can_atlas_2018", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 179, "note": null}, {"cohort": "paad_qcmg_uq_2016", "status": "observed", "frequency": 0.26, "altered": 1, "tested": 383, "note": null}, {"cohort": "pdac_msk_2024", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "CEACAM5", "kind": "SNV / small indel", "gene": "CEACAM5", "cells": [{"cohort": "paad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 0.56, "altered": 1, "tested": 179, "note": null}, {"cohort": "paad_qcmg_uq_2016", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 383, "note": null}, {"cohort": "pdac_msk_2024", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "MUC1", "kind": "SNV / small indel", "gene": "MUC1", "cells": [{"cohort": "paad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 0.56, "altered": 1, "tested": 179, "note": null}, {"cohort": "paad_qcmg_uq_2016", "status": "observed", "frequency": 0.26, "altered": 1, "tested": 383, "note": null}, {"cohort": "pdac_msk_2024", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "MUC1", "kind": "amplification", "gene": "MUC1", "cells": [{"cohort": "paad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.83, "altered": 7, "tested": 183, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "paad_qcmg_uq_2016", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "No copy-number profile is connected for this cohort."}, {"cohort": "pdac_msk_2024", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 2336, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "RNF43", "kind": "SNV / small indel", "gene": "RNF43", "cells": [{"cohort": "paad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 6.15, "altered": 11, "tested": 179, "note": null}, {"cohort": "paad_qcmg_uq_2016", "status": "observed", "frequency": 5.48, "altered": 21, "tested": 383, "note": null}, {"cohort": "pdac_msk_2024", "status": "observed", "frequency": 6.08, "altered": 142, "tested": 2336, "note": null}]}, {"label": "PCDH15", "kind": "SNV / small indel", "gene": "PCDH15", "cells": [{"cohort": "paad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 5.03, "altered": 9, "tested": 179, "note": null}, {"cohort": "paad_qcmg_uq_2016", "status": "observed", "frequency": 2.61, "altered": 10, "tested": 383, "note": null}, {"cohort": "pdac_msk_2024", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "ARID1A", "kind": "SNV / small indel", "gene": "ARID1A", "cells": [{"cohort": "paad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 5.03, "altered": 9, "tested": 179, "note": null}, {"cohort": "paad_qcmg_uq_2016", "status": "observed", "frequency": 7.57, "altered": 29, "tested": 383, "note": null}, {"cohort": "pdac_msk_2024", "status": "observed", "frequency": 8.73, "altered": 204, "tested": 2336, "note": null}]}, {"label": "TGFBR2", "kind": "SNV / small indel", "gene": "TGFBR2", "cells": [{"cohort": "paad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 4.47, "altered": 8, "tested": 179, "note": null}, {"cohort": "paad_qcmg_uq_2016", "status": "observed", "frequency": 4.7, "altered": 18, "tested": 383, "note": null}, {"cohort": "pdac_msk_2024", "status": "observed", "frequency": 3.9, "altered": 91, "tested": 2336, "note": null}]}, {"label": "RNF213", "kind": "SNV / small indel", "gene": "RNF213", "cells": [{"cohort": "paad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 4.47, "altered": 8, "tested": 179, "note": null}, {"cohort": "paad_qcmg_uq_2016", "status": "observed", "frequency": 1.31, "altered": 5, "tested": 383, "note": null}, {"cohort": "pdac_msk_2024", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "MYO18B", "kind": "SNV / small indel", "gene": "MYO18B", "cells": [{"cohort": "paad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 4.47, "altered": 8, "tested": 179, "note": null}, {"cohort": "paad_qcmg_uq_2016", "status": "observed", "frequency": 1.31, "altered": 5, "tested": 383, "note": null}, {"cohort": "pdac_msk_2024", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "HECW2", "kind": "SNV / small indel", "gene": "HECW2", "cells": [{"cohort": "paad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 4.47, "altered": 8, "tested": 179, "note": null}, {"cohort": "paad_qcmg_uq_2016", "status": "observed", "frequency": 0.52, "altered": 2, "tested": 383, "note": null}, {"cohort": "pdac_msk_2024", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "CACNA1B", "kind": "SNV / small indel", "gene": "CACNA1B", "cells": [{"cohort": "paad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 4.47, "altered": 8, "tested": 179, "note": null}, {"cohort": "paad_qcmg_uq_2016", "status": "observed", "frequency": 1.57, "altered": 6, "tested": 383, "note": null}, {"cohort": "pdac_msk_2024", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "SCN5A", "kind": "SNV / small indel", "gene": "SCN5A", "cells": [{"cohort": "paad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.91, "altered": 7, "tested": 179, "note": null}, {"cohort": "paad_qcmg_uq_2016", "status": "observed", "frequency": 1.57, "altered": 6, "tested": 383, "note": null}, {"cohort": "pdac_msk_2024", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "RREB1", "kind": "SNV / small indel", "gene": "RREB1", "cells": [{"cohort": "paad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.91, "altered": 7, "tested": 179, "note": null}, {"cohort": "paad_qcmg_uq_2016", "status": "observed", "frequency": 1.31, "altered": 5, "tested": 383, "note": null}, {"cohort": "pdac_msk_2024", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "RELN", "kind": "SNV / small indel", "gene": "RELN", "cells": [{"cohort": "paad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.91, "altered": 7, "tested": 179, "note": null}, {"cohort": "paad_qcmg_uq_2016", "status": "observed", "frequency": 2.35, "altered": 9, "tested": 383, "note": null}, {"cohort": "pdac_msk_2024", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "PCDHB7", "kind": "SNV / small indel", "gene": "PCDHB7", "cells": [{"cohort": "paad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.91, "altered": 7, "tested": 179, "note": null}, {"cohort": "paad_qcmg_uq_2016", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 383, "note": null}, {"cohort": "pdac_msk_2024", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "MAP3K21", "kind": "SNV / small indel", "gene": "MAP3K21", "cells": [{"cohort": "paad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.91, "altered": 7, "tested": 179, "note": null}, {"cohort": "paad_qcmg_uq_2016", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 383, "note": null}, {"cohort": "pdac_msk_2024", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "KMT2D", "kind": "SNV / small indel", "gene": "KMT2D", "cells": [{"cohort": "paad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.91, "altered": 7, "tested": 179, "note": null}, {"cohort": "paad_qcmg_uq_2016", "status": "observed", "frequency": 4.96, "altered": 19, "tested": 383, "note": null}, {"cohort": "pdac_msk_2024", "status": "observed", "frequency": 4.28, "altered": 100, "tested": 2336, "note": null}]}, {"label": "KMT2C", "kind": "SNV / small indel", "gene": "KMT2C", "cells": [{"cohort": "paad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.91, "altered": 7, "tested": 179, "note": null}, {"cohort": "paad_qcmg_uq_2016", "status": "observed", "frequency": 4.96, "altered": 19, "tested": 383, "note": null}, {"cohort": "pdac_msk_2024", "status": "observed", "frequency": 3.12, "altered": 73, "tested": 2336, "note": null}]}, {"label": "KDM6A", "kind": "SNV / small indel", "gene": "KDM6A", "cells": [{"cohort": "paad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.91, "altered": 7, "tested": 179, "note": null}, {"cohort": "paad_qcmg_uq_2016", "status": "observed", "frequency": 3.13, "altered": 12, "tested": 383, "note": null}, {"cohort": "pdac_msk_2024", "status": "observed", "frequency": 3.9, "altered": 91, "tested": 2336, "note": null}]}, {"label": "KDM6A", "kind": "deep deletion", "gene": "KDM6A", "cells": [{"cohort": "paad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 2.73, "altered": 5, "tested": 183, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "paad_qcmg_uq_2016", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "No copy-number profile is connected for this cohort."}, {"cohort": "pdac_msk_2024", "status": "observed", "frequency": 0.34, "altered": 8, "tested": 2336, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "GNAS", "kind": "SNV / small indel", "gene": "GNAS", "cells": [{"cohort": "paad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.91, "altered": 7, "tested": 179, "note": null}, {"cohort": "paad_qcmg_uq_2016", "status": "observed", "frequency": 2.61, "altered": 10, "tested": 383, "note": null}, {"cohort": "pdac_msk_2024", "status": "observed", "frequency": 3.25, "altered": 76, "tested": 2336, "note": null}]}, {"label": "GLI3", "kind": "SNV / small indel", "gene": "GLI3", "cells": [{"cohort": "paad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.91, "altered": 7, "tested": 179, "note": null}, {"cohort": "paad_qcmg_uq_2016", "status": "observed", "frequency": 4.7, "altered": 18, "tested": 383, "note": null}, {"cohort": "pdac_msk_2024", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "FLNC", "kind": "SNV / small indel", "gene": "FLNC", "cells": [{"cohort": "paad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.91, "altered": 7, "tested": 179, "note": null}, {"cohort": "paad_qcmg_uq_2016", "status": "observed", "frequency": 0.78, "altered": 3, "tested": 383, "note": null}, {"cohort": "pdac_msk_2024", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "FAT2", "kind": "SNV / small indel", "gene": "FAT2", "cells": [{"cohort": "paad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.91, "altered": 7, "tested": 179, "note": null}, {"cohort": "paad_qcmg_uq_2016", "status": "observed", "frequency": 0.78, "altered": 3, "tested": 383, "note": null}, {"cohort": "pdac_msk_2024", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "DSCAML1", "kind": "SNV / small indel", "gene": "DSCAML1", "cells": [{"cohort": "paad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.91, "altered": 7, "tested": 179, "note": null}, {"cohort": "paad_qcmg_uq_2016", "status": "observed", "frequency": 2.09, "altered": 8, "tested": 383, "note": null}, {"cohort": "pdac_msk_2024", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "COL6A2", "kind": "SNV / small indel", "gene": "COL6A2", "cells": [{"cohort": "paad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.91, "altered": 7, "tested": 179, "note": null}, {"cohort": "paad_qcmg_uq_2016", "status": "observed", "frequency": 0.78, "altered": 3, "tested": 383, "note": null}, {"cohort": "pdac_msk_2024", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "APBA2", "kind": "SNV / small indel", "gene": "APBA2", "cells": [{"cohort": "paad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.91, "altered": 7, "tested": 179, "note": null}, {"cohort": "paad_qcmg_uq_2016", "status": "observed", "frequency": 0.52, "altered": 2, "tested": 383, "note": null}, {"cohort": "pdac_msk_2024", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "ADAMTS12", "kind": "SNV / small indel", "gene": "ADAMTS12", "cells": [{"cohort": "paad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.91, "altered": 7, "tested": 179, "note": null}, {"cohort": "paad_qcmg_uq_2016", "status": "observed", "frequency": 0.52, "altered": 2, "tested": 383, "note": null}, {"cohort": "pdac_msk_2024", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "TPO", "kind": "SNV / small indel", "gene": "TPO", "cells": [{"cohort": "paad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.35, "altered": 6, "tested": 179, "note": null}, {"cohort": "paad_qcmg_uq_2016", "status": "observed", "frequency": 1.83, "altered": 7, "tested": 383, "note": null}, {"cohort": "pdac_msk_2024", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "PEG3", "kind": "SNV / small indel", "gene": "PEG3", "cells": [{"cohort": "paad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.35, "altered": 6, "tested": 179, "note": null}, {"cohort": "paad_qcmg_uq_2016", "status": "observed", "frequency": 1.57, "altered": 6, "tested": 383, "note": null}, {"cohort": "pdac_msk_2024", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "PCDH9", "kind": "SNV / small indel", "gene": "PCDH9", "cells": [{"cohort": "paad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.35, "altered": 6, "tested": 179, "note": null}, {"cohort": "paad_qcmg_uq_2016", "status": "observed", "frequency": 0.78, "altered": 3, "tested": 383, "note": null}, {"cohort": "pdac_msk_2024", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "NOS1", "kind": "SNV / small indel", "gene": "NOS1", "cells": [{"cohort": "paad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.35, "altered": 6, "tested": 179, "note": null}, {"cohort": "paad_qcmg_uq_2016", "status": "observed", "frequency": 1.83, "altered": 7, "tested": 383, "note": null}, {"cohort": "pdac_msk_2024", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "KCNA6", "kind": "SNV / small indel", "gene": "KCNA6", "cells": [{"cohort": "paad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.35, "altered": 6, "tested": 179, "note": null}, {"cohort": "paad_qcmg_uq_2016", "status": "observed", "frequency": 0.78, "altered": 3, "tested": 383, "note": null}, {"cohort": "pdac_msk_2024", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "KCNA6", "kind": "amplification", "gene": "KCNA6", "cells": [{"cohort": "paad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 2.73, "altered": 5, "tested": 183, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "paad_qcmg_uq_2016", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "No copy-number profile is connected for this cohort."}, {"cohort": "pdac_msk_2024", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 2336, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "FN1", "kind": "SNV / small indel", "gene": "FN1", "cells": [{"cohort": "paad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.35, "altered": 6, "tested": 179, "note": null}, {"cohort": "paad_qcmg_uq_2016", "status": "observed", "frequency": 1.83, "altered": 7, "tested": 383, "note": null}, {"cohort": "pdac_msk_2024", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "FLT4", "kind": "SNV / small indel", "gene": "FLT4", "cells": [{"cohort": "paad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.35, "altered": 6, "tested": 179, "note": null}, {"cohort": "paad_qcmg_uq_2016", "status": "observed", "frequency": 0.78, "altered": 3, "tested": 383, "note": null}, {"cohort": "pdac_msk_2024", "status": "observed", "frequency": 1.33, "altered": 31, "tested": 2336, "note": null}]}, {"label": "FLNA", "kind": "SNV / small indel", "gene": "FLNA", "cells": [{"cohort": "paad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.35, "altered": 6, "tested": 179, "note": null}, {"cohort": "paad_qcmg_uq_2016", "status": "observed", "frequency": 0.52, "altered": 2, "tested": 383, "note": null}, {"cohort": "pdac_msk_2024", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "FLNA", "kind": "amplification", "gene": "FLNA", "cells": [{"cohort": "paad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 2.19, "altered": 4, "tested": 183, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}, {"cohort": "paad_qcmg_uq_2016", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "No copy-number profile is connected for this cohort."}, {"cohort": "pdac_msk_2024", "status": "not_observed", "frequency": 0.0, "altered": 0, "tested": 2336, "note": "Discrete copy-number call; divides by the cohort's copy-number roster."}]}, {"label": "COL5A1", "kind": "SNV / small indel", "gene": "COL5A1", "cells": [{"cohort": "paad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.35, "altered": 6, "tested": 179, "note": null}, {"cohort": "paad_qcmg_uq_2016", "status": "observed", "frequency": 2.09, "altered": 8, "tested": 383, "note": null}, {"cohort": "pdac_msk_2024", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "ADAMTS16", "kind": "SNV / small indel", "gene": "ADAMTS16", "cells": [{"cohort": "paad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.35, "altered": 6, "tested": 179, "note": null}, {"cohort": "paad_qcmg_uq_2016", "status": "observed", "frequency": 1.31, "altered": 5, "tested": 383, "note": null}, {"cohort": "pdac_msk_2024", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}, {"label": "ABTB3", "kind": "SNV / small indel", "gene": "ABTB3", "cells": [{"cohort": "paad_tcga_pan_can_atlas_2018", "status": "observed", "frequency": 3.35, "altered": 6, "tested": 179, "note": null}, {"cohort": "paad_qcmg_uq_2016", "status": "observed", "frequency": 0.26, "altered": 1, "tested": 383, "note": null}, {"cohort": "pdac_msk_2024", "status": "not_assayed", "frequency": null, "altered": null, "tested": null, "note": "Not on this cohort's gene panel."}]}]}