Senior Associate Scientist, Synthesis, RNA Process Sciences

Senior Associate Scientist, Synthesis, RNA Process Sciences

At Bristol Myers Squibb, our employees often ask, “Who are you working for?”—a question that fuels collaboration, accountability, and urgency in our work. Our purpose-driven culture inspires us to discover, develop, and deliver innovative medicines to prevail over serious diseases. We offer uniquely interesting and meaningful work, opportunities for growth, and a supportive environment that values inclusion, wellbeing, flexibility, and comprehensive benefits. This is work that transforms the lives of patients, and the careers of those who do it.

Position Summary

The RNA Synthesis Process Sciences role plays a central part in collaborating with research and manufacturing to define early process conditions and scale down process development. By combining deep scientific expertise with enabling technologies and strong cross-functional partnerships, RNA Process Development delivers transformative innovation across the pipeline.

The Senior Associate Scientist provides scientific support for drug substance programs spanning preclinical to early-stage development across circular and linear mRNA modalities. This role encompasses hands-on contributions by driving sound experimental execution and establishing linkages from a research concept to manufacturing implementation. The candidate should be driven by developing and characterizing RNA synthesis processes for improving the yield, quality and robustness.

Key Responsibilities

• Apply high throughput and data driven approaches to perform early optimization and characterization of in vitro transcription, circularization and DNase reactions
• Support the RNA drug substance synthesis process definition and scale up
• Experiment using high throughput/automated or data rich experimental setups
• Support experiments to confirm robust process performance across the control space
• Collaborate with research teams to enable quicker transitions from drug candidate nomination to clinical manufacturing
• Prepare sections of technical reports, and communicate findings internally as appropriate
• Participate in tech transfer activities to GMP manufacturing sites for RNA programs

  Qualifications & Experience

  • Degree in Bio/Chemical Engineering, Bio/Chemistry, or related field
  • BS with 4+ years' experience in science related disciplines
  • MS with 2+ years' experience in science related disciplines
  • Knowledge of automated liquid handlers, small scale stir tank reactors, and other novel reactor designs
  • Working knowledge of statistical design of experiments (DoE) and analysis of multivariate data
  • Experience with performing process analytics and biophysical characterization techniques such as HPLC, CE, & gel electrophoresis
  • Hands-on experience programming/operating liquid handling systems, high throughput workflow design, LIMS/ELN systems for sample tracking, and scripting languages for instrument control is a plus
  • Knowledge of cGMP, ICH, regulatory guidelines and QbD principles as they apply to risk management and clinical manufacturing is a plus
  • Background in providing technical support for clinical manufacturing processes, including support of process investigations, and implementation of proactive process modifications is a plus
  • Knowledge of advanced mathematics, nucleic acid chemistry, lipid chemistry, and biology is a plus
  • Knowledge of establishing and qualifying scale down models and mechanistic models for process characterization is a plus

    We hire for skills and capabilities, not just credentials – if this role excites you, but doesn't perfectly match your resume, we encourage you to apply anyway.