Senior Principal Scientist – Neurology and Ophthalmology Imaging

Senior Principal Scientist, Ophthalmology & Neurology

We are seeking a Senior Principal Scientist with a focus in Ophthalmology and Neurology to join our Clinical Imaging team. You will conceptualize, support, execute, and optimize complex imaging measures and biomarkers in early- to late-phase clinical trials. You will work closely with Regeneron clinical, preclinical and external partners, with emphasis on delivery of high-quality imaging data and development of innovative imaging-based biomarkers across imaging modalities and indications.

Location: Tarrytown, NY United States

Discover your role:

• Guide Regeneron clinical teams as imaging subject matter expert to ensure optimal design and execution of imaging biomarker strategy related to study endpoints, including development of protocols, imaging manuals, imaging charters and statistical analysis plans, and be the main clinical team collaborate with imaging Clinical Research Organizations, ensuring flawless conduct and data integrity of study's imaging components.
• Collaborate closely with Research colleagues to develop and qualify imaging biomarkers with a view toward clinical translation.
• Lead the development and execution of innovative joint image analyses projects, including novel imaging biomarker development, while collaborating closely with different departments and functions such as Regeneron Genetics Center, Imaging Sciences, Translational Medicine, Biostatistics and Data Management, etc.
• Collaborate closely with external vendors, investigators and site personnel and Clinical operations teams to ensure the appropriate selection of Imaging equipment and parameters for image acquisition and pre- and on-study QC/calibration and standardization.
• Oversee image analysis and interpretation of results and work closely with colleagues to oversee the development of study reports and publications as appropriate.
• Support regulatory submission packages with the appropriate original content and documentation.

  This role requires:

  • Demonstrated outstanding oral and written communication skills.
  • Work efficiently within a fast-paced, collaborative environment.
  • Come up with new and outstanding ideas that move solutions forward.
  • Possess a broad knowledge and perspective and are future oriented.
  • Desire to make a broader impact on developing medicines for patients with serious diseases.
  • A PhD in a relevant field, with 6+ years of demonstrated ability in Ophthalmology and Neurology Clinical Imaging.
  • Extensive familiarity with ocular and neuro imaging modalities such as OCT, FA, CFP, MRI, PET etc.
  • A strong understanding of imaging file formats and analysis methods.
  • Demonstrated ability in the development and validation of imaging biomarkers.
  • Industry experience in creating and managing imaging protocols, manuals, and charters, and proficiency in statistical analysis plans related to imaging endpoints.