Scientist – RNA Sequencing / ddPCR

Scientist – RNA Sequencing / ddPCR

Position: Full-Time; Monday – Friday; 8am-5pm EST

This is a fully onsite role based at our customer's site in (insert location – i.e. Boston, MA). We welcome applicants from all locations within the US.

Must be legally authorized to work in the United States without sponsorship.

Must be able to pass a comprehensive background check, which includes a drug screening.

At Thermo Fisher Scientific, you'll discover meaningful work that makes a positive impact on a global scale. Join our colleagues in bringing our Mission to life – enabling our customers to make the world healthier, cleaner and safer.

Thermo Fisher's clinical research business is a leading global contract research organization and world leader in serving science. We are passionate, deliberate, and driven by our mission – to enable our customers to make the world healthier, safer, and cleaner.

Our Laboratories Functional Service Partnership (FSP) team plays a direct role in advancing drug development by creating sustained groups of talent within our customers' organizations to provide long-term support.

Key responsibilities:

• Independently design, execute, troubleshoot, optimize, and interpret analytical method development experiments using digital PCR, qPCR, ddPCR, bulk RNA sequencing
• NanoString nCounter, Oxford Nanopore sequencing NICE TO HAVE
• Perform DNA/RNA extraction, sequencing library preparation, sequencer operation, digital PCR workflows, and other associated laboratory procedures with a high standard of technical rigor.
• Design and conduct experiments to evaluate assay performance characteristics, including accuracy, precision, linearity, sensitivity, and technology comparisons.
• Analyze and interpret data using R, GraphPad Prism, JMP, and related bioinformatics tools to support assay development, process characterization, and technology evaluation.
• Organize, analyze, and summarize data for project updates, technical reports, study summaries, and internal presentations.
• Author and review protocols, SOPs, technical reports, study documentation, and regulatory support documents.
• Collaborate cross-functionally with partners in analytical development, process development, research, and other teams to support analytical strategy and project goals.
• Operate, maintain, and troubleshoot laboratory instrumentation, including NextSeq 2000, NovaSeq X, PromethION 24, NanoString nCounter Prep Station/Digital Analyzer, and digital PCR platforms.
• Maintain laboratory organization, instrument readiness, reagent inventory, and compliance with documentation and laboratory best practices.

  Education and Experience:

  • Bachelor's degree in lab sciences such as Chemistry, Biochemistry, Material Science, Immunology, Biology, Molecular Biology or similar
  • Scientist: Previous experience that provides the knowledge, skills, and abilities to perform the job (comparable to 2+ years')
  • OR Masters degree

    In some cases, an equivalency, consisting of a combination of appropriate education, training and/or directly related experience, will be considered sufficient for an individual to meet the requirements of the role.

    Knowledge, Skills and Abilities:

    • Digital PCR (ddPCR, dPCR)
    • qPCR
    • NanoString nCounter (NICE TO HAVE)
    • Bulk RNA-sequencing library preparation and sequencing
    • DNA/RNA extraction
    • Oxford Nanopore library preparation and sequencing workflows
    • Statistical analysis and data visualization using R, GraphPad Prism, JMP, and Microsoft Excel
    • Differential gene expression analysis using DESeq2
    • Pathway enrichment analysis using GSEA and Gene Ontology
    • Sequencing data quality control, interpretation, and reporting
    • Analysis of digital PCR and sequencing datasets to support method development and process characterization
    • Proficiency with Microsoft PowerPoint, Excel, and Word

      Working Environment:

      Below is listed the working environment/requirements for this role:

      Able to communicate, receive, and understand information and ideas with diverse groups of people in a comprehensible and reasonable manner.

      Able to work upright and stationary and/or standing for typical working hours.

      Able to lift and move objects up to 25 pounds

      Able to work in non-traditional work environments.

      Able to use and learn standard office equipment and technology with proficiency.

      May have exposure to potentially hazardous elements, including infectious agents, typically found in healthcare or laboratory environments.

      Able to perform successfully under pressure while prioritizing and handling multiple projects or activities.

      Benefits

      We offer competitive remuneration, annual incentive plan bonus, healthcare, and a range of employee benefits. Thermo Fisher Scientific offers employment with an innovative, forward-thinking organization, and outstanding career and development prospects. We offer an exciting company culture that stands for integrity, intensity, involvement, and innovation!

      Compensation and Benefits

      The hourly pay range estimated for this position based in Massachusetts is $35.00–$43.00.

      This position may also be eligible to receive a variable annual bonus based on company, team, and/or individual performance results in accordance with company policy. We offer a comprehensive Total Rewards package that our U.S. colleagues and their families can count on, which includes:

      • A choice of national medical and dental plans, and a national vision plan, including health incentive programs
      • Employee assistance and family support programs, including commuter benefits and tuition reimbursement
      • At least 120 hours paid time off (PTO), 10 paid holidays annually, paid parental leave (3 weeks for bonding and 8 weeks for caregiver leave), accident and life insurance, and short- and long-term disability in accordance with company policy
      • Retirement and savings programs, such as our competitive 401(k) U.S. retirement savings plan
      • Employees' Stock Purchase Plan (ESPP) offers eligible colleagues the opportunity to purchase company stock at a discount