Principal Research Scientist I

Principal Research Scientist

The Translational Safety Pharmacology department provides rigorous in vitro and in vivo safety assessments and fit-for-purpose assay development to enable informed discovery and development decisions. Cardiovascular safety pharmacology is central to advancing safe, high-quality medicines.

The Principal Research Scientist will serve as the in vivo cardiovascular safety pharmacology subject-matter leader, providing scientific and strategic leadership across rodent, canine, and nonhuman-primate models. This role leads the design, execution, interpretation, and reporting of cardiovascular safety studies; advances GLP and regulatory readiness; and partners across a matrixed organization to deliver reproducible, decision-ready data.

Responsibilities:

• Lead the design, execution, quality, interpretation, and reporting of in vivo cardiovascular safety pharmacology studies across rodent, canine, and nonhuman-primate models.
• Provide scientific leadership for cardiovascular assessments, including hemodynamics, ECG and electrophysiology, pressure-volume loops, echocardiography, vascular reactivity, thrombosis, and relevant disease models.
• Develop, optimize, validate, and implement fit-for-purpose cardiovascular assays and models; author and implement SOPs that support quality, consistency, and regulatory readiness.
• Champion data quality, reproducibility, and scientifically sound interpretation; mentor scientists; communicate study strategy, results, and risk assessments to senior leadership, cross-functional stakeholders, and regulatory-facing teams; and advance cardiovascular safety pharmacology capabilities, workflows, and technologies.
• Manage (directly and indirectly) team members in a matrixed environment to help plan, coordinate, and prioritize studies.

  Qualifications:

  • PhD in physiology, pharmacology, toxicology, or a related field, with 10+ years of relevant experience in cardiovascular biology, safety pharmacology, or a closely related discipline.
  • Demonstrated cardiovascular biology and safety pharmacology expertise, including the ability to design, execute, interpret, and report in vivo cardiovascular studies.
  • Experience with rodent and large-animal studies, including canine and nonhuman-primate models.
  • Experience authoring and implementing SOPs, with working knowledge of GLP, quality systems, and regulatory-ready documentation.
  • Strong written and verbal scientific communication skills; demonstrated ability to lead in a matrixed environment, apply critical thinking, troubleshoot complex study issues, and manage multiple priorities effectively.
  • At least one year of previous people management experience

    Compensation range: $124,500 – 236,500 USD

    AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.