Scientist, Non-Viral Gene Editing Platforms

Scientist, Non-Viral Gene Editing Platforms

At Bristol Myers Squibb, our employees often ask, “Who are you working for?”—a question that fuels collaboration, accountability, and urgency in our work. Our purpose-driven culture inspires us to discover, develop, and deliver innovative medicines to prevail over serious diseases. We offer uniquely interesting and meaningful work, opportunities for growth, and a supportive environment that values inclusion, wellbeing, flexibility, and comprehensive benefits. This is work that transforms the lives of patients, and the careers of those who do it.

The Cell Therapy Thematic Research Center is one of BMS's differentiated research platforms delivering innovative therapies to patients. Our mission is to drive leadership in the use of cellular therapies to harness the power of the immune system in treating hematologic malignancies, solid cancers, and autoimmune disease. More specifically, our discovery and translational scientists are focused on developing next-generation, engineered cell-based therapies. The team is committed to discovering and developing transformative therapies that harness the power of the immune system to improve patient outcomes.

Position Responsibilities

In this role as a Scientist, Non-Viral Gene Editing Platforms, the ideal candidate:

• Spends a majority of the time working in the lab independently executing experiments and recording detailed ELN entries
• Works diligently within the team to optimize base ex vivo editing platform and implement new technologies for continuous improvement and next-gen in vivo platform development (e.g., lipid nanoparticles)
• Routinely generates CAR-T cells including non-viral gene editing, expansion, and cryopreservation of engineered cells
• Thoroughly characterizes engineered CAR-T cells including phenotypic analysis via flow cytometry, in vitro cytotoxicity assays (e.g., Incucyte), and genomic DNA extraction for downstream molecular analysis
• Independently analyses and interprets experimental data, experience with large and complex datasets a plus
• Actively troubleshoots routine problems and initiatives related to continuous improvement or development of new approaches / technologies
• Proactively communicates and aligns with team members to achieve results and support cross-functional activities
• Generates key data to support decisions that impact the larger team
• Presents findings in multidisciplinary meetings, logically explaining complex scientific concepts and clearly highlighting key messages
• May represent department or team on program/project team or sub-team

  Experience:

  Basic Qualifications:

  • Bachelor's Degree
    • 5+ years of academic and / or industry experience

      Or

      • Master's Degree
        • 3+ years of academic and / or industry experience

          Or

          • Ph.D. or equivalent advanced degree in the Life Sciences

            Preferred Qualifications:

            • Hands-on experience with gene editing technologies (CRISPR/Prime editing preferred)
            • Experience with in vivo non-viral gene delivery platforms (including non-cell therapy applications)
            • Strong knowledge of molecular biology and prior experience with DNA design tools such as Benchling, Geneious, etc.
            • Experience culturing T cells including aseptic technique, T cell activation, and maintenance of primary cell cultures
            • Experience with multi-color flow cytometry including complex panel design and multi-parameter data analysis (FlowJo)
            • Ability to effectively multi-task, independently organize time, and can develop timelines and deliver results accordingly
            • Demonstrated ability to work within a team and thrive in a fast-paced and ever-changing environment
            • Detail oriented with excellent verbal and written communication skills and careful documentation (prior ELN experience a plus)

              Compensation Overview:

              Seattle – WA: $122,810 – $148,814

              The starting pay range(s) listed above is for full-time employees (FTE). You may also be eligible for additional discretionary incentive cash and stock opportunities. We determine starting pay thoughtfully – carefully considering the nature of the role, required skills, work location, schedule and the knowledge and experience you bring. Final compensation is guided by pay equity principles and applicable employment laws. Compensation programs are reviewed on an ongoing basis and may be adjusted over time to reflect evolving market factors, and individual, team or Company performance.

              Benefits:

              Subject to the terms and conditions of the applicable plans then in effect, you may be eligible to participate in our comprehensive benefit plans – including wellbeing support, retirement and financial protection benefits, and insurance offerings (medical, dental, vision, life and disability).

              U.S.-based exempt employees are eligible for Flexible Time Off (FTO), which provides paid time off without a set accrual limit, subject to manager approval, along with 11 paid company holidays each year.

              Non-exempt employees, RayzeBio employees, and employees located in Puerto Rico receive 160 hours of paid vacation annually for new hires (subject to manager approval), 11 paid company holidays, and 3 optional holidays.

              Depending on eligibility, employees may also have access to additional time-off benefits, including paid sick leave, up to two paid volunteer days per year, summer hours flexibility, and leaves of absence for medical, personal, parental, caregiver, bereavement, or military needs. Eligible employees also enjoy an annual Global Shutdown between Christmas Day and New Year's Day.

              U.S.-based job seekers can explore full benefit offerings at https://careers.bms.com/benefits

              How We Work

              Where you work matters – because collaboration, innovation and patient impact happen in many settings. Our roles are structured across four work models: site-essential, site-by-design, field-based and remote-by-design. The model assigned to this role is based on its core responsibilities. Learn more at https://careers.bms.com/ways-of-working.