Principal Scientist (m/f/d) Genomic Technologies, Human Genetics and Genomics

Principal Scientist (M/F/D) Genomic Technologies, Human Genetics And Genomics

This position may be based at a GSK R&D site in UK (Stevenage), in USA (Cambridge Tech Square, MA; or Upper Providence, PA), or in Germany (Heidelberg).

We are seeking an innovative scientist to join our team. The successful candidate will join the Genomic Technologies team, within GSK R&D Translational Sciences. In the Genomic Technologies group, we integrate deep and broad expertise in computational and statistical methods and techniques, to enable best-in-class analytical insight and interpretation of genetics and genomics data, to guide GSK's drug discovery and development portfolio and pipeline decisions.

The successful candidate will join an existing Statistical Genetics team and will work on projects aligned to current areas of focus, including:

• Discovery of new causal gene-phenotype links through analysis of large-scale individual level human genetic data.
• Identification of causal genes, disease-relevant mechanisms and cell types, potential drug targets, candidate biomarkers, patient subgroups and disease subtypes, through integration of genetic association data across multiple 'omic and phenotypic layers.
• Predictive modelling of presence, direction and magnitude of causal gene-phenotype links, using genetic and 'omic data, mechanistic annotation, inferred causal networks, and genome-scale perturbation data.

  We encourage applicants to describe in their cover letter how their qualifications, skills and experience would make them outstanding contributors to the work of Genomic Technologies and of HGG.

  Responsibilities

  • Evaluating, improving, testing, and developing production implementations of best-in-class methods for analysis of genetic data, in collaboration with scientists in Data and Predictive Sciences, Biostatistics, or/and AI/ML teams.
  • Generating large-scale analysis outputs, and/or implementing state-of-the-art tools for dynamically analysing, interpreting, and visualizing genetic and genomic data.
  • Collaborating with partners in applied and translational teams across HGG, in experimental Target Discovery, and in GSK disease area Research Units, to influence portfolio and pipeline decisions.
  • Staying informed about recent research in the field and considering its potential for application within GSK.
  • Contributing to a culture of innovation, quality, and willingness to learn and improve.

    Qualifications, Skills and Experience:

    • Advanced degree (PhD or equivalent) in a relevant scientific discipline.
    • Experience working with large scale biobank data, such as UK Biobank and All of Us.
    • Excellent programming skills in R or python, and application of techniques in reproducible research, literate programming, FAIR data principles, or software development.
    • Experience of evaluating, improving, testing, and/or developing methods for analysis and interpretation of large-scale genetics data.
    • Strong communication and team-working skills.

      Preferred Skills & Experience:

      • Deep understanding of statistical genetics methodology.
      • Experience working in cloud-based Trusted Research Environments.
      • Experience with machine learning and/or advanced statistical methods.
      • Experience working in multidisciplinary teams on complex and impactful projects.
      • Experience with analysis of very large datasets using distributed or cloud computing technologies (e.g. SQL, PySpark, BigQuery, Docker, Nextflow).