Principal Research Scientist I, Checkpoint Immunology

Principal Research Scientist I

The Checkpoint Immunology group is seeking an experienced Principal Research Scientist I to advance novel immune checkpoint programs for autoimmune and inflammatory diseases. The successful candidate will provide scientific leadership across discovery and translational research activities, driving innovative therapeutic concepts from target identification through candidate nomination.

This role is ideal for a scientist who combines deep immunology expertise with a strong drug discovery mindset, enjoys solving challenging biological questions in emerging areas of science, and thrives in a collaborative, cross-functional environment.

Responsibilities

• Lead the scientific strategy and execution of one or more discovery-stage immunology programs.
• Drive biological understanding of novel immune regulatory pathways and translate insights into therapeutic opportunities.
• Lead from the bench by designing, executing, and interpreting critical experiments while mentoring other scientists.
• Build scientific capability within the team and foster a strong drug discovery mindset
• Integrate biology, pharmacology, translational sciences, and external collaborations to advance program objectives.
• Coordinate cross-functional workflows and drive alignment across multidisciplinary teams.
• Ensure high-quality project planning through sound experimental design, early risk assessment and robust contingency planning through integrated timelines
• Contribute to PK/PD, translational, and biomarker strategies that support candidate selection and development decisions.
• Foster a collaborative, high-performing team culture through mentorship, scientific rigor, and effective teamwork.

  Qualifications

  Required

  • PhD with typically 6+ years of experience; MS or equivalent education with typically 12+ years of experience; or BS or equivalent education with typically 14+ years of extensive experience in Immunology, Cell Biology, Pharmacology, or related discipline.
  • Significant experience in immunology drug discovery; proven ability to innovate and deliver new or improved lead and candidate molecules
  • Experience with biologics, bispecific antibodies, multispecific therapeutics, or other immune-modulating modalities
  • Strong expertise in immune cell biology, autoimmune disease, immune regulation, and/or checkpoint biology.
  • Demonstrated ability to independently lead scientific strategy and execution in a matrixed environment.
  • Excellent communication, collaboration, and problem-solving skills.

    Preferred

    • Experience advancing programs from target validation through candidate nomination.
    • Experience designing and interpreting in vitro and in vivo pharmacology studies, including PK/PD assessments.
    • Translational research and biomarker development experience.
    • Proven ability to integrate cross-functional activities and drive execution across complex research programs.

      The Ideal Candidate

      We are looking for a scientist who can lead biology in areas where the path forward is not yet defined, remain closely connected to the science and the laboratory, integrate activities across diverse functions, and help build a cohesive, collaborative team. This individual will be recognized for scientific excellence, strong execution, mentorship, and the ability to translate complex biology into impactful therapeutic strategies.

      Pay Range: $ 124500 – 236500 USD