Senior Scientist, siRNA Synthesis

Principal Research Scientist I

The Biotherapeutic and Genetic Medicine (BGM) department at AbbVie is seeking a motivated Principal Research Scientist I to join the growing siRNA team. In this role, you will work with the genetic medicine teams to establish siRNA synthesis, purification, and analytical capabilities. This individual will serve as a subject matter expert in oligonucleotide synthesis and purification, with responsibility for generating high-quality siRNA materials for advancing genetic medicine studies.

Responsibilities:

• Lead the siRNA synthesis platform to support various stages of siRNA studies.
• Perform solid-phase oligonucleotide synthesis, deprotection, purification, and desalting of siRNA.
• Troubleshoot synthesis and purification challenges to improve yield, purity, and scalability.
• Work closely with the siRNA analytical colleagues to support characterization, data interpretation, and quality assessment of siRNA materials.
• Collaborate closely with the conjugation team to advance siRNA conjugate development and support platform and project objectives.
• Ensure rigorous documentation, data integrity, and compliance with internal quality standards.
• Track emerging technologies and best practices in oligonucleotide and RNA-based therapeutics.
• Mentor junior scientists and contribute to a collaborative, high-performing team environment.

  Qualifications:

  • BS, MS, or PhD in Chemistry, Chemical Biology, Biochemistry, or a related field with typically 0-4+ years (PhD), 8-10+ years (MS), or 10-12+ years (BS) of relevant biotech or pharmaceutical industry experience.
  • Proven track record in gram-scale oligonucleotide synthesis using oligonucleotide synthesizers, as well as development of oligonucleotide purification methods using liquid chromatography systems.
  • Strong knowledge of oligonucleotide chemistry and RNA chemistry.
  • Experience working cross-functionally with analytical and conjugation teams.
  • Demonstrated ability to independently solve complex technical problems and drive projects forward.
  • Excellent communication, collaboration, and organizational skills.
  • Strong track record of presenting scientific data to internal and external stakeholders.

    Position will be filled at level commensurate with extent of education, experience, and accomplishment – Senior Scientist I or Senior Scientist II

    Additional Information:

    • The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.
    • We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
    • This job is eligible to participate in our short-term incentive programs.
    • This job is may be eligible to participate in our long-term incentive programs.

      AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.