Assistant Project Scientist in single cell Genomics and disease modeling

Assistant Or Associate Project Scientist

An NIH-funded full-time position for an Assistant or Associate Project Scientist is immediately available, supervised by Dr. Daniel Geschwind in the Department of Neurology in the David Geffen School of Medicine at UCLA. We are looking for a motivated individual interested in working at the interface of genetics, single cell genomics, and disease modeling to investigate the mechanisms of disease genetics through single cell mutliomics and spatial transcriptomics.

The Geschwind lab is located within the Gonda building and Departments of Neurology, Psychiatry and Human Genetics at UCLA. The Geschwind Lab focuses on experimental and developmental neurobiology, modeling of human cortical development using stem cells, and gene regulation and employs systems-level, computational, multi-omic approaches using human brain samples to investigate the biological mechanisms underlying genetic risk for neurodevelopmental and psychiatric disorders, including autism. Our long-term goals are to translate genetic findings into practical therapeutics for neuropsychiatric disease.

Requirements

• PhD in biological sciences
• Expertise with multi-omic library generation from postmortem brain
• Expertise in Spatial Transcriptomics
• Fluency with bioinformatic analysis pipelines for single cell RNA and ATAC as well as Spatial omics
• Knowledge and background experience of working with ASD and ASD model systems
• Ability to work independently within a collaborative multi-disciplinary team-based environment
• Motivation to learn and develop expertise in cutting-edge genome engineering and stem cell-based methodologies
• Strong oral and written communication skills to present and publish research findings
• Track record training and mentoring junior scientists

  Experience with neural stem cell models, functional genomics assays (e.g., scRNA-seq, ATAC-seq), and/or CRISPR/Cas9 genome engineering are required. All backgrounds will be considered. The appointed researcher will be embedded within a highly interdisciplinary team of neural stem cell and developmental biologists, computational biologists, bioinformaticians, statistical geneticists, and clinicians. The successful candidate will help develop and implement high-throughput genome engineering and genomic assays in cortical organoid cultures established from patient stem cell lines. Training opportunities and mentorship in wet-lab stem cell modeling and dry-lab genomics techniques will be provided by the PI.

  Application Procedure: Apply by submitting your application to our online RECRUIT system at Browse Open Recruitments or Log In – UCLA Academic RECRUIT Screening of applicants will begin immediately and will continue until the position is filled.

  Document requirements Curriculum Vitae – Your most recently updated C.V. Cover Letter (Optional) Statement of Research (Optional) Reference check authorization release form – Complete and upload the reference check authorization release form

  The posted UC salary scales set the minimum pay determined by rank and step at appointment. See T37 B

  The salary range for this position is $79,400- $92,200

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