Senior Research Fellow

Senior Research Fellow

An exciting opportunity has arisen for an enthusiastic Senior Research Fellow to join our dynamic team within the Molecular & Cellular Immunology Unit at UCL Great Ormond Street Institute of Child Health. The MRC Centre of Research Excellence in Therapeutic Genomics (MRC CoRE TG) is a £50 million, 14-year international initiative to mass-produce and deliver affordable genetic therapies for currently untreatable rare conditions. The research fellow will be part of a large, international, collaborative effort focused on therapy for rare genetic disorders and the group aims are to revolutionise how therapies are identified, developed, and brought to the clinic for rare genetic disorders of the blood, eyes, and brain. The post will primarily be involved to assist in the development of scalable gene editing platform to engineer therapeutic T cells for clinical trials in inherited disorders. This post will form part of a large, international, collaborative effort focused on therapy for rare genetic disorders. The Senior Research Fellow will be expected to carry out GMP optimisation manufacturing which will include cell culture, set-up, running, analysis of quality control, process validations and completion of all accompanying documentation including writing SOPS. This post will focus on genome-targeted therapies, primarily CRISPR-based genome editing techniques, that use genetic code to target specific genes. Genome-targeting brings specificity, by treating the genetic cause the disorder, but also flexibility, since a successful therapy could be'reprogrammed' to another disorder in the same tissue by changing just the genetic code used for targeting. This is a research project focused on rare diseases. You will be based within a busy research team, working with external partners. You will be expected to have good organisational skills and excellent attention to detail in laboratory work.

An experienced postdoc, highly motivated and capable individual with prior Knowledge and experience in gene editing and CRISPR/Cas system. Experience in LAM-PCR, NGS, qPCR essential. Please see attached JD/ PS for detailed information.

41 Days holiday (27 days annual leave 8 bank holiday and 6 closure days) • Additional 5 days' annual leave purchase scheme • Defined benefit career average revalued earnings pension scheme (CARE) • Cycle to work scheme and season ticket loan • Immigration loan • Relocation scheme for certain posts • On-Site nursery • On-site gym • Enhanced maternity, paternity and adoption pay • Employee assistance programme: Staff Support Service • Discounted medical insurance Visit https://www.ucl.ac.uk/work-at-ucl/reward-and-benefits to find out more.

As London's Global University, we know diversity fosters creativity and innovation, and we want our community to represent the diversity of the world's talent. We are committed to equality of opportunity, to being fair and inclusive, and to being a place where we all belong. We therefore particularly encourage applications from candidates who are likely to be underrepresented in UCL's workforce. These include people from Black, Asian and ethnic minority backgrounds; disabled people; LGBTQI+ people; and for our Grade 9 and 10 roles, women. You can read more about our commitment to Equality, Diversity and Inclusion here : https://www.ucl.ac.uk/equality-diversity-inclusion/ If you have any queries regarding the application process, please contact Madhur Sharma on ich.hr@ucl.ac.uk quoting job reference