Associate Principal Scientist, Discovery Oncology, Reverse Translation

Associate Principal Scientist

We are seeking a highly motivated Associate Principal Scientist to join a bicoastal Discovery Oncology, Reverse Translation Team in South San Francisco. This role is an exciting opportunity to contribute to reverse translation efforts that leverage clinical insights, in vitro systems, and in vivo oncology models to identify novel therapeutic targets and elucidate mechanisms of tumor biology, disease progression, and therapeutic response. The successful candidate will work collaboratively with cross-functional team members to design, execute, analyze, and present high-quality laboratory studies, while providing scientific input to maximize the therapeutic opportunity of our current and growing pipeline. The ideal candidate will bring deep expertise in cancer biology, a track record of scientific rigor, independent thinking, and a collaborative mindset. Excellent organizational, oral, and written communication skills are essential, as is the ability to thrive in a fast-paced, multidisciplinary research environment.

Education:

• Ph.D. in Cancer Biology, Immunology, Molecular Biology, Biochemistry, Oncology, or a related STEM field, with at least four (4) years of postdoctoral training or relevant experience in industry or academia; MS and 7+ years of experience; OR BS and 11+ years of experience.

  Required experience and skills:

  • In-depth knowledge of cancer biology, tumor biology, and mechanisms of therapeutic response and resistance.
  • Track record of scientific rigor, creativity, and impact in relevant areas of oncology research, ideally demonstrated through publications and patents
  • Clear evidence of independent scientific leadership, experimental design, and delivery of actionable results.
  • Extensive hands-on experience with in vitro cell-based assays and multiparametric flow cytometry.
  • Strong foundation in molecular and cellular biology techniques for target identification and validation, including but not limited to RT-PCR, protein quantification, in vitro overexpression, knock-in, knock-out, and cell line generation approaches.
  • Ability to deliver complex objectives under aggressive timelines in a rapidly changing research environment.
  • Excellent communication, presentation, collaboration, time-management, and organizational skills.

    Preferred experience and skills:

    • Previous experience contributing to reverse translation projects that integrate clinical observations with preclinical experimental strategies.
    • Experience working with large datasets, patient-derived data, and/or multi-omics approaches to generate biologically meaningful hypotheses.
    • Experience working across different therapeutic modalities, including bispecific antibodies, antibody-drug conjugates (ADCs), and small molecules

      Required Skills:

      Biology, Cancer Biology, Cancer Therapy, Cell Biology, In Vitro Pharmacology, In Vitro Research, Molecular Biology, Oncology, Preclinical Research, Target Validation, Tumor Biology, Tumor Models

      Preferred Skills:

      Antibodies, Antibody Drug Conjugates (ADC), Monoclonal Antibodies, Omics Technologies, Reverse Transcription

      The salary range for this role is $159,600.00 – $251,200.00

      This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee's position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs.

      The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.

      We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits.