Scientist I/II, In Vivo Pharmacology – Immuno-oncology

Job Opportunity at AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience – and products and services in our Allergan Aesthetics portfolio.

Our expanding In Vivo Pharmacology group in South San Francisco, CA has an opening for a motivated tumor biologist who is dedicated to the discovery and development of innovative therapeutics, both small molecule and biologics, with a focus on immuno-oncology. The Scientist I will perform tumor efficacy and PK/PD studies and provide pharmacology support to innovative cancer drug development. The scientist will work collaboratively in a project team setting with biology, medicinal chemistry, biologics, and DMPK scientists to advance oncology programs through the R&D pipeline.

Key Accountabilities/Core Job Responsibilities:

• Design, execute and optimize efficacy/PK/PD studies utilizing tumor models in both immunocompetent and immunocompromised mice.
• Understand and adhere to IACUC protocols regarding animal welfare and handling.
• Data analyses and presentation of pharmacodynamic/disease results, and work across discovery teams to integrate efficient workflows for cross-functional collaborations.
• Commitment to scientific rigor, high data quality and careful documentation.

  Qualifications

  Required Qualifications:

  • Scientist I: MS with 2+ years of experience, or BS with 5+ years of experience
  • Scientist II: MS with 5+ years of experience, or BS with 7+ years of experience
  • Degree in cancer biology, immunology, pharmacology, or a related with extensive hands-on skills of in vivo tumor model execution; preferably in a pharmaceutical or biotech industry setting.
  • Proficient hands-on experience with in vivo pharmacodynamic and tumor models, including anesthetization, biological sample collection (blood, spleen, lymph node, etc.), cell/drug administration via different routes/sites (SC, IP, PO, IV), and tumor volume measurement.
  • Technical experience and knowledge in tissue culture and immune cell isolation from lymphoid tissue are desired.
  • Knowledge of PK/PD relationships, flow cytometry, and other standard molecular and cellular biology assays (MSD, ELISA, etc.) are advantages.
  • Understanding of in vivo optical imaging approaches and familiarity with instrumentation (e.g. IVIS instrument) is also an advantage.
  • Must be proactive and able to manage multiple responsibilities, adapt to changing priorities and meet deadlines in a fast-paced environment.
  • Excellent verbal and written communication skills and the willingness to work and build strong relationships with peers in a multidisciplinary team are essential.
  • Flexibility and motivation to learn techniques and accomplish goals outside those stated above.

    Additional Information

    • The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.
    • We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
    • This job is eligible to participate in our short-term incentive programs.

      AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

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        Pay Range: $84500 – 162000 USD

        Where We Work

        Role is exclusively performed at a site or office and onsite presence is required. Employees who are site/office-based and can occasionally perform their role virtually work both in the office and remotely*, following the policies and regulations in place at their location. US Employees must be in the office on Tuesday, Wednesday, and Thursday with flexibility to work remotely on Mondays and Fridays. Three days in the office is the minimum; some individuals or teams may require more in-office days due to meetings, business/project needs or their role.