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2 jobs
1 day, 16 hours ago · via jobRxiv
Research Fellow
Research Fellow This is an exciting opportunity to join the Cortese Laboratory as a Research Fellow, contributing to the development of novel therapeutic strategies for RFC1 CANVAS and related repeat expansion disorders. Building on recent findings demonstrating the potential of CRISPR/Cas9 genome editing to restore RFC1 expression and function, you will investigate complementary therapeutic approaches, including gene reprovision, CRISPR-based activation of endogenous RFC1 and small-molecule str
3 weeks ago · via jobRxiv
Postdoctoral Research Scientist
Postdoctoral Research Scientist This post will investigate how Parkinson's disease-associated genetic perturbations alter mitochondrial function and cellular metabolism in human neurons. The postholder will extend, quality-control and use focused CRISPRi/a sgRNA libraries in iPSC-derived cortical neurons and validate priority findings in iPSC-derived dopaminergic neurons. Cellular responses will be characterised using established high-content imaging, quantitative cellular phenotyping and a
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