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RNAseq from MDA-MB-231 shYB-1 and sh control

GSE117856 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2026/07/08 Platform GPL16791
Summary
Elevated YB-1 expression correlates with poor patient survival and drug resistance in diverse tumor types, notably in metastatic tumors. In this report, we characterized the role of YB-1 in breast tumor initiation and progression, in primary cells or cell lines. Notably, YB-1 blockade in MDA-MB-231 cells shown that YB-1 has a major role in tumor progression and dissemination, but not in in vitro settings. Our data suggests induction of YB-1 expression is associated with the activation of a HIF1α program.
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Also filed as BioProject PRJNA483448 and SRA study SRP155737. Searching any of these in the dataset finder brings you back here.

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