GEO series
RNA levels in wild-type and HIF1α-mutant MCF7 cells in normoxia (21% O2), and in hypoxia (1% O2) for 3 h or 24 h
GSE122059
Homo sapiens
Expression profiling by high throughput sequencing
18 samples
2024/03/11
GPL16791
Summary
We report the generation of CRISPR/Cas9-engineered MCF7 human breast cancer cells that lack functional HIF1α. We show that the HIF1α-dependent transcriptional response to hypoxia is severely impaired in HIF1α-mutant MCF7 cells.
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Paper (PMID 38485816) ↗
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