GEO series

TGFβ/mutant-p53 jointly controlled genes

GSE14491 Homo sapiens Expression profiling by array 16 samples Submitted 2009/04/03 Platform GPL570

Summary

TGFβ ligands act as tumor suppressors in early stage tumors but are paradoxically diverted into potent prometastatic factors in advanced cancers. The molecular nature of this switch remains enigmatic. We now show that TGFβ-dependent cell migration, invasion and metastasis are empowered by mutant-p53. To investigate the specific gene expression program by which mutant-p53 and TGFβ control invasion and metastasis in breast cancer cells, we compared the TGFβ transcriptomic profile of control and mutant-p53 depleted MDA-MB-231 cells. Keywords: expression profiling by array

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Direct links to NCBI, no account and no request form: the whole study as GSE14491_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 16 samples.

Whole study · RAW.tar ↓ Series matrix ↓ All supplementary files ↗

Also filed as BioProject PRJNA111547. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 19345189) ↗

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