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Transfer RNA fragments replace microRNA regulators of the cholinergic post-stroke immune blockade II

GSE158312 Homo sapiens Expression profiling by high throughput sequencing 24 samples Submitted 2020/12/31 Platform GPL18573
Summary
After ischemic stroke, the brain initiates intensive communication with the immune system, and acetylcholine contributes to this process. Stroke triggers peripheral immunosuppression leading to increased susceptibility to infections; and post-stroke pneumonia is linked with poor stroke outcome, but the responsible processes are yet unknown. We discovered a “change of guards” where microRNA levels decreased but small transfer RNA fragments (tRFs) accumulated in post-stroke blood cells. This molecular switch may re-balance acetylcholine signaling in CD14+ monocytes by regulating their gene expression and modulating post-stroke immunity. Our observations point to tRFs as new molecular regulators of post-stroke immune responses that may become potential therapeutic targets.
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Also filed as BioProject PRJNA664794 and SRA study SRP284293. Searching any of these in the dataset finder brings you back here.

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