GEO series
The mechano-biological microenvironment of pancreatic ductal adenocarcinoma
GSE168574
Homo sapiens
Expression profiling by high throughput sequencing
12 samples
2025/12/16
GPL24676
Summary
GelMA hydrogels of different stiffness (5% and 7.5%) provide a microenvironment capable of directing not only pancreatic cancer cell growth but also stiffness- and matrisome-related gene programs. BxPC-3 and PANC-1 cells were chosen for this analysis as representative epithelial and mesenchymal-like cell lines respectively. Transcriptomic signatures of GelMA-embedded cells were compared against those of cells cultured in commonly-used collagen hydrogels (Col).
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Paper (PMID 41386414) ↗
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