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SFPQ rescues F508del-CFTR expression and function in cystic fibrosis bronchial epithelial cells

GSE174160 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2026/04/21 Platform GPL16791
Summary
Here, we investigated the role of SFPQ in the regulation of expression and function of F508del-CFTR in CF lung epithelial cells. We find that the expression of SFPQ is reduced in F508del-CFTR CF epithelial cells compared to WT-CFTR control cells. Interestingly, the overexpression of SFPQ in CF cells increases the expression as well as rescues the function of F508del­CFTR. Further, comprehensive transcriptome analyses indicate that SFPQ plays a key role in activating the mutant F508del-CFTR by modulating several cellular signaling pathways. This is the first report on the role of SFPQ in the regulation of expression and function of F508del-CFTR in CF lung disease.
Published in
SFPQ rescues F508del-CFTR expression and function in cystic fibrosis bronchial epithelial cells
Kumar P, Soni DK, Sen C et al. · Scientific reports 2021 · PMID 34404863 · doi:10.1038/s41598-021-96141-w
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Also filed as BioProject PRJNA728652 and SRA study SRP319174. Searching any of these in the dataset finder brings you back here.

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