GEO series
RNA Sequencing Analysis of Wild Type and Non-phosphorylatable CARM1 mutation knock-in HEL cells
GSE174432
Homo sapiens
Expression profiling by high throughput sequencing
21 samples
2024/04/03
GPL24676
Summary
CARM1 is essential for the development and maintenance of myeloid neoplasms. We found that non-phosphorylatable CARM1 mutation impairs cell cycle progression, induces apoptosis, and downregulates stemness in JAK2-mutant cell lines, suggesting that CARM1 phosphorylation is required for maximal proliferation of myeloid neoplasms.
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Paper (PMID 38649367) ↗
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