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Epigenomic profile of bladder cancer cell line HT1376 treated with CPI-0209

GSE176486 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 5 samples Submitted 2024/06/26 Platform GPL18573
Summary
Advanced bladder cancer remains a difficult cancer to treat, and for the majority of patients, current standard treatments ultimately prove ineffective.  These tumors frequently harbor mutations in the BAF complex subunit ARID1A, which has been reported to confer sensitivity to EZH2 inhibition in several tumor types.  Here we describe the generation of CPI-0209, a best-in-class, orally available EZH2 inhibitor.  We show that mutant bladder cancer lines harboring ARID1A loss of function (LOF) mutations are preferentially sensitive to inhibition of EZH2. Treatment with CPI-0209 not only elicits a significant monotherapeutic response in ARID1A mutant models, it also outperforms cisplatin and improves response in chemo-resistant models. These findings shine light on new therapeutic opportunities for patients with advanced urothelial carcinoma.  
Published in
Comprehensive Target Engagement by the EZH2 Inhibitor Tulmimetostat Allows for Targeting of ARID1A Mutant Cancers
Keller PJ, Adams EJ, Wu R et al. · Cancer research 2024 · PMID 38833522 · doi:10.1158/0008-5472.CAN-24-0398
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Direct links to NCBI, no account and no request form: the whole study as GSE176486_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 5 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA736422 and SRA study SRP323407. Searching any of these in the dataset finder brings you back here.

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