GEO series
Transcriptomic responses in the host during mosquito-transmitted and blood passaged Plasmodium chabaudi infections.
GSE178515
Mus musculus
Expression profiling by high throughput sequencing
87 samples
2024/06/12
GPL17021
Summary
Plasmoidium chabuadi AS infections initiated by mosquito transmitted infections give rise to an attenuated blood-stage infection when compared to serially blood passaged parasites. Furthermore, Plasmoidium chabuadi CB infections have an increased virulence as compared with Plasmoidium chabuadi AS. We compared the immune response in the spleens induced by these two types of parasites and two types of infection routes in order to determine what may cause this attenuation. Spleens were taken at several timepoints during the blood-stage infection and RNA-seq analysis was performed.
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