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FoxM1-Retinoblastoma Interaction Induces Tumor Microenvironment That Drives Metastasis

GSE178612 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2024/06/20 Platform GPL19057
Summary
A mouse strain expressing an Rb-binding deficient mutant of FoxM1, FoxM1 DD, develops PyMT-driven mammary tumors that are deficient in metastasis. Single-cell RNA-Seq analyses revealed altered tumor microenvironment (TME). Unlike the FoxM1 +/+ tumors, the FoxM1 DD/DD tumors lack tumor-infiltrating cells, resulting from a deficiency in the tumor cell-populations that express factors necessary for their recruitment. Furthermore, FoxM1 DD/DD tumors contain fewer mammary cancer stem/progenitor cells, but more differentiated tumor cells.
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Direct links to NCBI, no account and no request form: the whole study as GSE178612_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA739718 and SRA study SRP324908. Searching any of these in the dataset finder brings you back here.

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