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RNA-seq and Ribo-Seq of human iPSC-ECs treated with DMSO or sunitinib for 24 hours

GSE181278 Homo sapiens Expression profiling by high throughput sequencing; Other 8 samples Submitted 2024/08/01 Platform GPL20301
Summary
Sunitinib is a receptor tyrosine kinase (RTK) inhibitor that is widely used for treatment of various types of cancer. Vascular toxicity represents a debilitating side-effect of sunitinib which impends its application in some patients. Study of sunitinib has been primarily focused on transcriptional control, and there is an important gap in our understanding of its impact on translation. To interrogate the role of mRNA translation in mediating the effect of sunitinib on endothelial cells (ECs) we performed ribosome footprinting.
Published in
Translational regulation of SND1 governs endothelial homeostasis during stress
Han Z, Yan G, Jousma J et al. · The Journal of clinical investigation 2025 · PMID 39895626 · doi:10.1172/JCI168730
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Direct links to NCBI, no account and no request form: the whole study as GSE181278_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 8 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA751389 and SRA study SRP330775. Searching any of these in the dataset finder brings you back here.

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