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Cellular states are coupled to genomic and viral heterogeneity in HPV-related oropharyngeal carcinoma

GSE182227 Homo sapiens Expression profiling by high throughput sequencing 24 samples Submitted 2022/11/30 Platform GPL24676
Summary
Head and neck squamous cell carcinoma (HNSCC) includes a large subset of cancers that are driven by the human papilloma virus (HPV) and occur primarily in the oropharynx. Here, we use 10x single cell RNA-seq to profile 70,970 cells from 11 HPV-positive and 5 HPV-negative oropharyngeal tumors in order to uncover diversity in chromosomal aberrations, cellular states and viral gene expression between and within tumors.
Published in
Cellular states are coupled to genomic and viral heterogeneity in HPV-related oropharyngeal carcinoma
Puram SV, Mints M, Pal A et al. · Nature genetics 2023 · PMID 37012457 · doi:10.1038/s41588-023-01357-3
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Direct links to NCBI, no account and no request form: the whole study as GSE182227_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 24 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA755331 and SRA study SRP332742. Searching any of these in the dataset finder brings you back here.

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