Influenza-induced activation of recruited alveolar macrophages during the early inflammatory phase drives lung injury and lethality
RNA-seq (gene expression) · mouse · 27 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 27 samples: 8 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE182637_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA757241 and SRA study SRP333843. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 27 samples.
How we read this: 8 replicated groups read from 27 sample titles; they account for 27 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM5533997 MoAM WT D2 rep2 MoAM WT D2
- GSM5533998 MoAM WT D2 rep3 MoAM WT D2
- GSM5533999 MoAM WT D2 rep4 MoAM WT D2
- GSM5534000 MoAM WT D3 rep1 MoAM WT D3
- GSM5534001 MoAM WT D3 rep2 MoAM WT D3
- GSM5534002 MoAM WT D3 rep3 MoAM WT D3
- GSM5534003 MoAM WT D4 rep2 MoAM WT D4
- GSM5534004 MoAM WT D4 rep1 MoAM WT D4
- GSM5534005 MoAM WT D4 rep3 MoAM WT D4
- GSM5534006 MoAM WT D6 rep1 MoAM WT D6
- GSM5534007 MoAM WT D6 rep2 MoAM WT D6
- GSM5534008 MoAM WT D6 rep3 MoAM WT D6
- GSM5534009 MoAM WT D6 rep4 MoAM WT D6
- GSM5534010 MoAM VimKO D2 rep1 MoAM VimKO D2
- GSM5534011 MoAM VimKO D2 rep2 MoAM VimKO D2
- GSM5534012 MoAM VimKO D2 rep3 MoAM VimKO D2
- GSM5534013 MoAM VimKO D3 rep1 MoAM VimKO D3
- GSM5534014 MoAM VimKO D3 rep2 MoAM VimKO D3
- GSM5534015 MoAM VimKO D3 rep3 MoAM VimKO D3
- GSM5534016 MoAM VimKO D3 rep4 MoAM VimKO D3
- GSM5534017 MoAM VimKO D4 rep1 MoAM VimKO D4
- GSM5534018 MoAM VimKO D4 rep2 MoAM VimKO D4
- GSM5534019 MoAM VimKO D4 rep3 MoAM VimKO D4
- GSM5534020 MoAM VimKO D6 rep1 MoAM VimKO D6
- GSM5534021 MoAM VimKO D6 rep2 MoAM VimKO D6
- GSM5534022 MoAM VimKO D6 rep3 MoAM VimKO D6
- GSM5534023 MoAM VimKO D6 rep4 MoAM VimKO D6
- GSE327565 Sustained Yap/Taz activation promotes aberrant alveolar epithelial cell differentiation and drives persistent fibrotic remodeling 14 samples shares activation, alveolar, drives
- GSE297515 Piezo1-dependent activation of stromal cells ignites muscle inflammation in exercise and injury and is associated with inflammaging 90 samples shares activation, injury
- GSE303772 Ontogenically distinct alveolar macrophages mediate cigarette smoke-induced inflammation and damage [RNA-Seq] 24 samples shares macrophages, alveolar
- GSE314207 Alveolar Macrophages Undergo a Postnatal Transition from a Hyperphagocytic and Proinflammatory Profile to a Tolerogenic Profile 24 samples shares macrophages, alveolar
- GSE279117 HIF1α deletion promotes mitochondrial repurposing in bone marrow-derived macrophages, but not in tissue-resident alveolar macrophages 24 samples shares macrophages, alveolar
- GSE239287 Single-cell transcriptome sequencing of macrophages in acute kidney injury(AKI) to chronic kidney dieases(CKD) 17 samples shares macrophages, injury
- GSE247504 Sustained NF-kB activation allows mutant alveolar stem cells to co-opt a regeneration program for tumor initiation [Expt2] 10 samples shares activation, alveolar
- GSE281001 The C3-C3aR axis modulates trained immunity in alveolar macrophages 8 samples shares macrophages, alveolar
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.