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Cellular Atlas of Human Heart Failure

GSE183852 Homo sapiens Expression profiling by high throughput sequencing 45 samples Submitted 2022/01/28 Platform GPL24676
Summary
Heart failure represents a major cause of morbidity and mortality worldwide. Single cell transcriptomics have revolutionized our understanding of cell composition and associated gene expression across human tissues. Through integrated analysis of single cell and single nucleus RNA sequencing data generated from 45 individuals, we define the cell composition of the healthy and failing human heart. We identify cell specific transcriptional signatures of heart failure and reveal the emergence of disease associated cell states. Intriguingly, cardiomyocytes converge towards a common disease associated cell state, while fibroblasts and myeloid cells undergo dramatic diversification. Endothelial cells and pericytes display global transcriptional shifts without changes in cell complexity. Collectively, our findings provide a comprehensive analysis of the cellular and transcriptomic landscape of human heart failure, identify cell type specific transcriptional programs and states associated with disease, and establish a valuable resource for the investigation of human heart failure.
Published in
Single-cell transcriptomics reveals cell-type-specific diversification in human heart failure
Koenig AL, Shchukina I, Amrute J et al. · Nature cardiovascular research 2022 · PMID 35959412 · doi:10.1038/s44161-022-00028-6
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Also filed as BioProject PRJNA762100 and SRA study SRP336428. Searching any of these in the dataset finder brings you back here.

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