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Next Generation Sequencing Facilitates Quantitative Analysis of KMT2C Knockdown/Control VCaP Cell Line Transcriptomes

GSE184867 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2025/02/12 Platform GPL24676
Summary
Prostate cancer (PCa) is a leading cause of male morbidity and mortality. Epigenetic modifier abnormalities are becoming a driving event in prostate cancer (PCa). The specific role of KMT2C, a histone methyltransferase that is frequently aberrant in various tumors, is poorly understood in PCa. This study aimed to reveal the potential carcinogenic role of KMT2C in PCa. Herein we confirmed the KMT2C overexpression in PCa, at transcript and protein level. Knockdown KMT2C in VCaP and LNCaP cells attenuated malignant phenotype, suppressing cell viability, clony, and migration. Consistently, stable KMT2C depletion effectively decreases tumor growth by about 70% in vivo. Mechanically, the results suggest that CLDN8 and ITGAV are two key downstream genes of KMT2C.
Published in
Histone methyltransferase KMT2C plays an oncogenic role in prostate cancer
Lian J, Xu C, Chen X et al. · Journal of cancer research and clinical oncology 2022 · PMID 35322299 · doi:10.1007/s00432-022-03968-5
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Also filed as BioProject PRJNA766685 and SRA study SRP338968. Searching any of these in the dataset finder brings you back here.

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