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BACH1 as a master regulator gene in vascular cells during aging

GSE185210 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2024/09/15 Platform GPL24676
Summary
We identify transcription factor BACH1 as a master regulator in vascular cells during aging. BACH1 is upregulated in the aorta of old mice. We find BACH1 is located on open chromatin and BACH1 binds to CDKN1A gene enhancer and activates its transcription in endothelial cells. Finally, BACH1 aggravates endothelial cell senescence under oxidative stress. Thus, these findings demonstrate a crucial regulatory role of BACH1 in vascular aging.
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Also filed as BioProject PRJNA768263 and SRA study SRP339814. Searching any of these in the dataset finder brings you back here.

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