Genome-wide changes in RNAPII occupancy, RNAPII phosphorylation, and transcription in response to CDK12/13 inhibition in gliomas
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 20 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 20 samples: 16 distinct titles, 2 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- CDK12/CDK13 inhibition disrupts transcriptional elongation and replication fork progression in glioblastomaEMBO molecular medicine · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE186311_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA773371 and SRA study SRP342520. Searching any of these in the dataset finder brings you back here.
How we read this: Read from 20 sample titles: 16 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM5643594 G7_Input_1hr_THZ531
- GSM5643595 G7_Input_6hrs_THZ531
- GSM5643596 G7_Input_6hrs_DMSO
- GSM5643597 G7_H3K27ac_6hrs_DMSO
- GSM5643598 G7_H3K27me3_6hrs_DMSO
- GSM5643599 G7_RNAPolII_1hr_THZ531
- GSM5643600 G7_RNAPolII_6hrs_THZ531
- GSM5643601 G7_RNAPolII_6hrs_DMSO
- GSM5643602 G7_RNAPolIIS2P_1hr_THZ531
- GSM5643603 G7_RNAPolIIS2P_6hrs_THZ531
- GSM5643604 G7_RNAPolIIS2P_6hrs_DMSO
- GSM5643605 G7_RNAPolIIS5P_1hr_THZ531
- GSM5643606 G7_RNAPolIIS5P_6hrs_THZ531
- GSM5643607 G7_RNAPolIIS5P_6hrs_DMSO
- GSM5643608 G7_DMSO_repl1
- GSM5643609 G7_DMSO_repl2
- GSM5643610 G7_DMSO_repl3
- GSM5643611 G7_6hrs_THZ531_repl1
- GSM5643612 G7_6hrs_THZ531_repl2
- GSM5643613 G7_6hrs_THZ531_repl3
- GSE273326 A trimeric USP11-USP7-TCEAL1 complex stabilizes paused RNAPII to sustain oncogenic transcription 63 samples shares rnapii, transcription
- GSE316989 Targeting CDK12/CYCLIN K induces a gene activation program which is mediated by P-TEFb [Cut&RUN] 10 samples shares cdk12
- GSE316689 Targeting CDK12/CYCLIN K induces a gene activation program which is mediated by P-TEFb 8 samples shares cdk12
- GSE303478 Systematic investigation reveals extensive Epstein-Barr virus transcriptional regulation of the human genome 217 samples shares transcription
- GSE296192 Hypoxic regulation of chromatin and gene transcription 98 samples shares transcription
- GSE301298 Functional redundancy between UTY and UTX in regulating the localization of transcription factors involved in pluripotency 88 samples shares transcription
- GSE306993 Transcriptional and epigenetic targets of MEF2C in human microglia contribute to cellular functions related to autism risk and age-related disease. 76 samples shares transcription
- GSE253121 NELF prevents transcriptional readthrough into DNA replication zones in cancer cells 70 samples shares transcription
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.