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Affymetrix SNP array data for non-small cell lung cancer cell line samples

GSE18797 Homo sapiens SNP genotyping by SNP array; Genome variation profiling by SNP array 12 samples Submitted 2009/10/30 Platform GPL3720
Summary
HCC827 cells were exposed in vitro to the irreversible EGFR inhibitor PF00299804 and resistant clones were isolated. These resistant clones (HCC827 PFR) contained an amplification of the MET gene and the growth of the HCC827 PFR cells was inhibited with the combination of PF00299804 and a MET kinase inhibitor. Phenotypically, these HCC827 PFR cells were similar to our previously identified gefitinib resistant HCC827 (HCC827 GR) cells (Engelman et al. Science 2007). In order to compare global genomic changes between HCC827 GR and HCC827 PFR cells and to determine whether the MET amplicon was similar in both drug resistant cells we performed a genome wide SNP analysis.
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Also filed as BioProject PRJNA121205. Searching any of these in the dataset finder brings you back here.

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